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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:ACO2-AHRR (FusionGDB2 ID:1464) |
Fusion Gene Summary for ACO2-AHRR |
Fusion gene summary |
Fusion gene information | Fusion gene name: ACO2-AHRR | Fusion gene ID: 1464 | Hgene | Tgene | Gene symbol | ACO2 | AHRR | Gene ID | 50 | 57491 |
Gene name | aconitase 2 | aryl-hydrocarbon receptor repressor | |
Synonyms | ACONM|HEL-S-284|ICRD|OCA8|OPA9 | AHH|AHHR|bHLHe77 | |
Cytomap | 22q13.2 | 5p15.33 | |
Type of gene | protein-coding | protein-coding | |
Description | aconitate hydratase, mitochondrialaconitase 2, mitochondrialcitrate hydro-lyaseepididymis secretory sperm binding protein Li 284mitochondrial aconitase | aryl hydrocarbon receptor repressorahR repressoraryl hydrocarbon hydroxylase regulatorclass E basic helix-loop-helix protein 77dioxin receptor repressor | |
Modification date | 20200313 | 20200322 | |
UniProtAcc | . | A9YTQ3 | |
Ensembl transtripts involved in fusion gene | ENST00000216254, ENST00000396512, ENST00000466237, | ENST00000505113, ENST00000316418, ENST00000512529, ENST00000515206, ENST00000506456, | |
Fusion gene scores | * DoF score | 17 X 8 X 10=1360 | 7 X 6 X 4=168 |
# samples | 22 | 9 | |
** MAII score | log2(22/1360*10)=-2.62803122261304 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACO2 [Title/Abstract] AND AHRR [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ACO2(41865186)-AHRR(422844), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACO2 | GO:0006099 | tricarboxylic acid cycle | 9630632 |
Hgene | ACO2 | GO:0006101 | citrate metabolic process | 9630632 |
Fusion gene breakpoints across ACO2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across AHRR (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SKCM | TCGA-EB-A5KH-06A | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
ChimerDB4 | SKCM | TCGA-EB-A5KH-06A | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
ChimerDB4 | SKCM | TCGA-EB-A5KH-06A | ACO2 | chr22 | 41865186 | - | AHRR | chr5 | 422844 | + |
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Fusion Gene ORF analysis for ACO2-AHRR |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000216254 | ENST00000505113 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
In-frame | ENST00000216254 | ENST00000316418 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
5CDS-5UTR | ENST00000216254 | ENST00000512529 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
5CDS-intron | ENST00000216254 | ENST00000515206 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
5CDS-intron | ENST00000216254 | ENST00000506456 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
In-frame | ENST00000396512 | ENST00000505113 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
In-frame | ENST00000396512 | ENST00000316418 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
5CDS-5UTR | ENST00000396512 | ENST00000512529 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
5CDS-intron | ENST00000396512 | ENST00000515206 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
5CDS-intron | ENST00000396512 | ENST00000506456 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
intron-3CDS | ENST00000466237 | ENST00000505113 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
intron-3CDS | ENST00000466237 | ENST00000316418 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
intron-5UTR | ENST00000466237 | ENST00000512529 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
intron-intron | ENST00000466237 | ENST00000515206 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
intron-intron | ENST00000466237 | ENST00000506456 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000216254 | ACO2 | chr22 | 41865186 | + | ENST00000505113 | AHRR | chr5 | 422844 | + | 1734 | 58 | 7 | 1710 | 567 |
ENST00000216254 | ACO2 | chr22 | 41865186 | + | ENST00000316418 | AHRR | chr5 | 422844 | + | 5222 | 58 | 7 | 1764 | 585 |
ENST00000396512 | ACO2 | chr22 | 41865186 | + | ENST00000505113 | AHRR | chr5 | 422844 | + | 1729 | 53 | 2 | 1705 | 567 |
ENST00000396512 | ACO2 | chr22 | 41865186 | + | ENST00000316418 | AHRR | chr5 | 422844 | + | 5217 | 53 | 2 | 1759 | 585 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000216254 | ENST00000505113 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + | 0.1619256 | 0.83807445 |
ENST00000216254 | ENST00000316418 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + | 0.071650505 | 0.9283495 |
ENST00000396512 | ENST00000505113 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + | 0.16139737 | 0.8386026 |
ENST00000396512 | ENST00000316418 | ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422844 | + | 0.07170811 | 0.92829186 |
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Fusion Genomic Features for ACO2-AHRR |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422843 | + | 2.88E-08 | 1 |
ACO2 | chr22 | 41865186 | + | AHRR | chr5 | 422843 | + | 2.88E-08 | 1 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ACO2-AHRR |
Go to FGviewer for the breakpoints of chr22:41865186-chr5:422844 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | AHRR |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. {ECO:0000269|PubMed:17890447, ECO:0000269|PubMed:18172554}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | AHRR | chr22:41865186 | chr5:422844 | ENST00000316418 | 4 | 12 | 551_701 | 151.0 | 720.0 | Region | Needed for transcriptional repression | |
Tgene | AHRR | chr22:41865186 | chr5:422844 | ENST00000505113 | 4 | 11 | 551_701 | 151.0 | 702.0 | Region | Needed for transcriptional repression |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ACO2 | chr22:41865186 | chr5:422844 | ENST00000216254 | + | 1 | 18 | 192_194 | 12.0 | 781.0 | Region | Substrate binding |
Hgene | ACO2 | chr22:41865186 | chr5:422844 | ENST00000216254 | + | 1 | 18 | 670_671 | 12.0 | 781.0 | Region | Substrate binding |
Tgene | AHRR | chr22:41865186 | chr5:422844 | ENST00000316418 | 4 | 12 | 112_182 | 151.0 | 720.0 | Domain | PAS | |
Tgene | AHRR | chr22:41865186 | chr5:422844 | ENST00000316418 | 4 | 12 | 28_81 | 151.0 | 720.0 | Domain | bHLH | |
Tgene | AHRR | chr22:41865186 | chr5:422844 | ENST00000505113 | 4 | 11 | 112_182 | 151.0 | 702.0 | Domain | PAS | |
Tgene | AHRR | chr22:41865186 | chr5:422844 | ENST00000505113 | 4 | 11 | 28_81 | 151.0 | 702.0 | Domain | bHLH |
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Fusion Gene Sequence for ACO2-AHRR |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000216254_ENST00000505113_TCGA-EB-A5KH-06A_ACO2_chr22_41865186_+_AHRR_chr5_422844_length(transcript)=1734nt_BP=58nt CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTA CATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTT GGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGAC CCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTT TGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGC AGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCAC CAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACA GACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGG GGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAA GCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCC CATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAG TGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCT GCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCC TCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTG TGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTC TCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCT GACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGG CCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCA CAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATA >In-frame_ENST00000216254_ENST00000505113_TCGA-EB-A5KH-06A_ACO2_chr22_41865186_+_AHRR_chr5_422844_length(amino acids)=567AA_start in transcript=7_stop in transcript=1710 MSVHKMAPYSLLVTRLQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRC FICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSL CESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPL PWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQH QLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQ QVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKREPLDSPQWATHSQ -------------------------------------------------------------- >In-frame_ENST00000216254_ENST00000316418_TCGA-EB-A5KH-06A_ACO2_chr22_41865186_+_AHRR_chr5_422844_length(transcript)=5222nt_BP=58nt CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTA CATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTT GGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGAC CCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGGCCCGGGGGTCACAGGCTTGGCAGCTGCGGCTCTG CTGTCCCGAGCCACTCATGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCT CCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGC AAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAA TTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAG GGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGAT GCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGA TGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGT CCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGA TGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTT TGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGA TGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAG GAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGG CGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGA GCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGA GGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAG TGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCAGTGACCACCATCCAAGCTCAGATCTGTGTGT CTACGCTCAGATGCGTCGGTGGCTGGGCTGCCCTGCTCCTGGTCAGGCCGGAGCCCGTCCTAAGACACACGCTTTGCAGAGCTGTGCATG CGCAGTCTGCTAGTGTGTGTGTGCAGCATACGCAGGAGCCTATCCTGAATTTTGTAAAATATCCCAACAGTTCTTAAATGAAAACTGGCC TTAAGTCTATTCAAGCATGACAGCATTTCTCTTTGAGGAATTAAAATCTTTAGGAAAGTGATCATGGCTGGACAGCTTCATGCCCCAGAG GCAGCGAGCACCCGTCCCATGGCTGCCAAGTCCACAGTCGGGGATGAAGCAGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGC GGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGACACACCTAGCTCAGCCCTCCCAGGCCACCTGCAGCTCCCA GCCTGTGCTGTGCAGGCAGGGTCAGCCCATCGCCACAGTGCACTGTAGAGGCCAGCACACGGCAAATTAGAAATACAACACGCGGAGAAA GGGGTCCGTGAGCCCACTCATAGAGGAATCTAGAACGTTCCAGGCAGCAGAGGCTGGCAGCGTGGGTCCCACACTGCCCCACACCGTGCG GCAGGTGCTCCATGGCGCCATGACAGAGTCTGAGGCCAGACCTGGACTGGAATTGACAGCATAACCCCTGTTCCTTCTGGACATCTCCCG AGTTCTCAGTGGGTCTCTGCGGACGGTTCTTCCTAATCTGCCTCTTGGTACATCACGTAATACAGAGTTCACAGACTCCGGGTTTGGAAG TACAGAGAAACACACAACGTAGAGAGAAGACACAGGAAACTGCGCTGCCTGTGGGGGTTTCTCTCTGGCTGGCTGTACAGTTCACTCAAA TGAGGGTTCCCATTGCCATCCTAGGAGAATAATTAGGGACAAGACAGACAAGTATTAATAGCATTAAAACAGTTGTAAAGGCGATATTTT CTGAGAGTAGGAAATTTGGATACAAAAGCATAAGTCAGAAAGTGAAGGTCACCAATCCACCAACCCGAGAACCTACAGCTGATGGTGCAT TTCAGGCTTCTTCCACGGTCTGGCCTGGAACCCCACCCGGCTGGTGCAGGCATCAGATCAGGGTGTAGAAGTCACCCCAAGCAAGAGGAA GCCAGGCAGTGAGGCCCTGGGGTGTGGCTGCAGCTGGGCCCACCTGTGCGGGGGTGGGAAGGCCCCATCCTCAGGGAGAGGGCATCGGCG CCCTGACGTCAGCTCCACTGGGAGTGGCAGGAGCTGTGGGAGCCCATGGGTGAGGGACCCACCACCCCGCTGCACTGTGCATTGTGCCTC CCGTGTGGACGCCCTCTCTGTTGTTGGCCCGCGGGTGAGGGACCCACCACCCCTAGGGACCCACCACCCCGCCGCACTGTGCATTCTGCC TCCTGTGTGGACGCCCTCTCTGTTGTCAGTGGCTTTGAGGTGTCAGTGCTTACTTAGATGCTGGTTTAATGCTGGACCCATTTGTTAAAC GCACCTTCACTTTGTCAAAACCCAGGTTTGGTTGGCAGGACTGGGTCTTCTGCCCAATGCCAGGTGCCTGCGCCTCTCAGTGGCCTGGTT CTTGGACAGTTTGCCCCCATGTGGCAGGGATAGGGATAAGGATCTCCTCTCAGTACTGGAAGAGAACAGCCAACCATCTGAGCCCAGAGT CACAGATCCATCGTGGCCCCCTATGACCCCCAAGCCCTACCGAGGGGGCACTCACTCTCTGCTTAGCCAGGGGGCGTCTTTCAAAAGGTG ACCTCCATGCTGTGCTGTCGTGGGTGTGAGACGTGCTCATGGCCTTCCACTGCCATCTCTCCCTTATCTGATGCCTAAAGTCACGATGGG GACAGAGCTACCCAGGGGCCAGCCATGGGGTGACCAGCCACCTGAGGGTCAGTCACCTGTGGAGAGCAGGCACCTGTGAAGACCAGGCAC CTGAGGACTGGCGCCTACTTCCCACTTTGGCCCTACACTGGCACAGAGCCCCTCTTTATTCATTTCTCATGCTGAGCATGGCACACTTCT GGCCTCTGGGCATTTATGGATTTAAGACCAGGATGGTATTTCAGAAGCTTCCCACTTCCTTCCTATTCTAACCGAGTGCCCAGCTCCTTT GCTGATCATGGAAAGACCCTTAATAATTAGGCCTGCAGGCCAGGCGCAGTGGCTCATGCCTATAATCCCAGCACTTTAGGAGGTCAAGGT AGGAGGATCGCTTAAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGGAAGAATGTGTCTCTACAAAAAATAATTAAAAATCAGATCT GCTGTATCCCTGAAAAAGTCTCAATCAACATGCATGTTCCACTCTTGGAGTTCCCTGTTCTGAGGGCCAGCCACGTCCTGTGTCCTGGAG CTTAGCCCTCAGCAGCTCCCTTCAGCCTGGGCGCCGCCTGGGTCCCAAACGTGGCAGCTGCTCTTCCAGTCTCGGGGCCGAGGAGGGCAG GGAGCTCAGTGACTGAGAGTCTTGTGTATCACATGTCTTGAGTGTCCTGGAGCCAACGGCTGTCACTGGGAAAAACACCAGGCCCCAAAG ATCGAATCAGAGACGTGGCTGCGTGTTTGCGATTGTAGCCAGGCCCTTCAGTGTCATCAAAGGAGCACTGGGGCCTCCTTAAGCACAGAC GGCAGCCCCTGCCCAGGAGGCTTCTTCACCACGTCCTGCCCTGCAGCCTCCCAGACCTTTAGATGCGCCCCTGCCCAAGGCCCTCCTGGT GACAGGTGCCAGATTGAGTGGTGGGTTGCTGCCAGGCAGGCCACGCTGTGTTGACGCTGCACTCAGCACGTGGGTGTTGGCTCTGCCGGT TTTGTGGTGTGGGGACCCTACAGGAGGCTGCGGCCCTGAGAGCCTGGGATCAGCGAGGTGTCCGACATCCCTTCCTCAACGGCAACAAAA ACTCCCCAAGTCAGCACTTTGGTTATTTTATAGCCACAACCCTCTTGGAAAACAGTGGGGAAGACTATGGAACATAGAAAGTGTGGATGT ATCACTTCTCTCTAAAATGTCATTGTTAGCACTAATTACAGGTTCATGTTTTTCTGTGTATGTAGCTTTTCCCTATATAGCTGAAAAAGT ATTAAAGTCAAATATAAGGTGGGAATGGGATGGAAGGGAGGAGATCAATACAACTTATATTTTTGCAGTTTCTACTGGAAGAAAAAAGTT TTCAATACCTAGACCAACTTGTTGAATTTTTAAAACTTATGCACTATAAATGCAACTTTCTCTACTGCTTTCTCAGTGCCTTTAGGAAGC TTTCAAATTTTTTTGTACTGTGGTTTGTATTAAATTTGCAATATTGATGTAAAATACATGACATGCTAGTACATGTTTAACAAAAATTTA >In-frame_ENST00000216254_ENST00000316418_TCGA-EB-A5KH-06A_ACO2_chr22_41865186_+_AHRR_chr5_422844_length(amino acids)=585AA_start in transcript=7_stop in transcript=1764 MSVHKMAPYSLLVTRLQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRC FICRVRCLLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKP RADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLS RASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVG EDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSH PATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAA -------------------------------------------------------------- >In-frame_ENST00000396512_ENST00000505113_TCGA-EB-A5KH-06A_ACO2_chr22_41865186_+_AHRR_chr5_422844_length(transcript)=1729nt_BP=53nt CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTACATCC ACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGA CAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGACCCGCT GCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGAC AGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGG AGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTC TGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTG ACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCT CAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCC TGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGC CCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCT ACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGC ACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGG GGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGC CCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGC AACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCC CTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAG GTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCC AGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCA >In-frame_ENST00000396512_ENST00000505113_TCGA-EB-A5KH-06A_ACO2_chr22_41865186_+_AHRR_chr5_422844_length(amino acids)=567AA_start in transcript=2_stop in transcript=1705 LSVHKMAPYSLLVTRLQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRC FICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSL CESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPL PWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQH QLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQ QVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKREPLDSPQWATHSQ -------------------------------------------------------------- >In-frame_ENST00000396512_ENST00000316418_TCGA-EB-A5KH-06A_ACO2_chr22_41865186_+_AHRR_chr5_422844_length(transcript)=5217nt_BP=53nt CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTACATCC ACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGA CAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGACCCGCT GCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGGCCCGGGGGTCACAGGCTTGGCAGCTGCGGCTCTGCTGTC CCGAGCCACTCATGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGC CGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAAC CCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACT CAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCC CATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGA GCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTG CCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGG GCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCG GTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCA CGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGT CCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCC ACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGC GGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCA CAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCG CCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCT TGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCAGTGACCACCATCCAAGCTCAGATCTGTGTGTCTACG CTCAGATGCGTCGGTGGCTGGGCTGCCCTGCTCCTGGTCAGGCCGGAGCCCGTCCTAAGACACACGCTTTGCAGAGCTGTGCATGCGCAG TCTGCTAGTGTGTGTGTGCAGCATACGCAGGAGCCTATCCTGAATTTTGTAAAATATCCCAACAGTTCTTAAATGAAAACTGGCCTTAAG TCTATTCAAGCATGACAGCATTTCTCTTTGAGGAATTAAAATCTTTAGGAAAGTGATCATGGCTGGACAGCTTCATGCCCCAGAGGCAGC GAGCACCCGTCCCATGGCTGCCAAGTCCACAGTCGGGGATGAAGCAGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCG GGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGACACACCTAGCTCAGCCCTCCCAGGCCACCTGCAGCTCCCAGCCTG TGCTGTGCAGGCAGGGTCAGCCCATCGCCACAGTGCACTGTAGAGGCCAGCACACGGCAAATTAGAAATACAACACGCGGAGAAAGGGGT CCGTGAGCCCACTCATAGAGGAATCTAGAACGTTCCAGGCAGCAGAGGCTGGCAGCGTGGGTCCCACACTGCCCCACACCGTGCGGCAGG TGCTCCATGGCGCCATGACAGAGTCTGAGGCCAGACCTGGACTGGAATTGACAGCATAACCCCTGTTCCTTCTGGACATCTCCCGAGTTC TCAGTGGGTCTCTGCGGACGGTTCTTCCTAATCTGCCTCTTGGTACATCACGTAATACAGAGTTCACAGACTCCGGGTTTGGAAGTACAG AGAAACACACAACGTAGAGAGAAGACACAGGAAACTGCGCTGCCTGTGGGGGTTTCTCTCTGGCTGGCTGTACAGTTCACTCAAATGAGG GTTCCCATTGCCATCCTAGGAGAATAATTAGGGACAAGACAGACAAGTATTAATAGCATTAAAACAGTTGTAAAGGCGATATTTTCTGAG AGTAGGAAATTTGGATACAAAAGCATAAGTCAGAAAGTGAAGGTCACCAATCCACCAACCCGAGAACCTACAGCTGATGGTGCATTTCAG GCTTCTTCCACGGTCTGGCCTGGAACCCCACCCGGCTGGTGCAGGCATCAGATCAGGGTGTAGAAGTCACCCCAAGCAAGAGGAAGCCAG GCAGTGAGGCCCTGGGGTGTGGCTGCAGCTGGGCCCACCTGTGCGGGGGTGGGAAGGCCCCATCCTCAGGGAGAGGGCATCGGCGCCCTG ACGTCAGCTCCACTGGGAGTGGCAGGAGCTGTGGGAGCCCATGGGTGAGGGACCCACCACCCCGCTGCACTGTGCATTGTGCCTCCCGTG TGGACGCCCTCTCTGTTGTTGGCCCGCGGGTGAGGGACCCACCACCCCTAGGGACCCACCACCCCGCCGCACTGTGCATTCTGCCTCCTG TGTGGACGCCCTCTCTGTTGTCAGTGGCTTTGAGGTGTCAGTGCTTACTTAGATGCTGGTTTAATGCTGGACCCATTTGTTAAACGCACC TTCACTTTGTCAAAACCCAGGTTTGGTTGGCAGGACTGGGTCTTCTGCCCAATGCCAGGTGCCTGCGCCTCTCAGTGGCCTGGTTCTTGG ACAGTTTGCCCCCATGTGGCAGGGATAGGGATAAGGATCTCCTCTCAGTACTGGAAGAGAACAGCCAACCATCTGAGCCCAGAGTCACAG ATCCATCGTGGCCCCCTATGACCCCCAAGCCCTACCGAGGGGGCACTCACTCTCTGCTTAGCCAGGGGGCGTCTTTCAAAAGGTGACCTC CATGCTGTGCTGTCGTGGGTGTGAGACGTGCTCATGGCCTTCCACTGCCATCTCTCCCTTATCTGATGCCTAAAGTCACGATGGGGACAG AGCTACCCAGGGGCCAGCCATGGGGTGACCAGCCACCTGAGGGTCAGTCACCTGTGGAGAGCAGGCACCTGTGAAGACCAGGCACCTGAG GACTGGCGCCTACTTCCCACTTTGGCCCTACACTGGCACAGAGCCCCTCTTTATTCATTTCTCATGCTGAGCATGGCACACTTCTGGCCT CTGGGCATTTATGGATTTAAGACCAGGATGGTATTTCAGAAGCTTCCCACTTCCTTCCTATTCTAACCGAGTGCCCAGCTCCTTTGCTGA TCATGGAAAGACCCTTAATAATTAGGCCTGCAGGCCAGGCGCAGTGGCTCATGCCTATAATCCCAGCACTTTAGGAGGTCAAGGTAGGAG GATCGCTTAAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGGAAGAATGTGTCTCTACAAAAAATAATTAAAAATCAGATCTGCTGT ATCCCTGAAAAAGTCTCAATCAACATGCATGTTCCACTCTTGGAGTTCCCTGTTCTGAGGGCCAGCCACGTCCTGTGTCCTGGAGCTTAG CCCTCAGCAGCTCCCTTCAGCCTGGGCGCCGCCTGGGTCCCAAACGTGGCAGCTGCTCTTCCAGTCTCGGGGCCGAGGAGGGCAGGGAGC TCAGTGACTGAGAGTCTTGTGTATCACATGTCTTGAGTGTCCTGGAGCCAACGGCTGTCACTGGGAAAAACACCAGGCCCCAAAGATCGA ATCAGAGACGTGGCTGCGTGTTTGCGATTGTAGCCAGGCCCTTCAGTGTCATCAAAGGAGCACTGGGGCCTCCTTAAGCACAGACGGCAG CCCCTGCCCAGGAGGCTTCTTCACCACGTCCTGCCCTGCAGCCTCCCAGACCTTTAGATGCGCCCCTGCCCAAGGCCCTCCTGGTGACAG GTGCCAGATTGAGTGGTGGGTTGCTGCCAGGCAGGCCACGCTGTGTTGACGCTGCACTCAGCACGTGGGTGTTGGCTCTGCCGGTTTTGT GGTGTGGGGACCCTACAGGAGGCTGCGGCCCTGAGAGCCTGGGATCAGCGAGGTGTCCGACATCCCTTCCTCAACGGCAACAAAAACTCC CCAAGTCAGCACTTTGGTTATTTTATAGCCACAACCCTCTTGGAAAACAGTGGGGAAGACTATGGAACATAGAAAGTGTGGATGTATCAC TTCTCTCTAAAATGTCATTGTTAGCACTAATTACAGGTTCATGTTTTTCTGTGTATGTAGCTTTTCCCTATATAGCTGAAAAAGTATTAA AGTCAAATATAAGGTGGGAATGGGATGGAAGGGAGGAGATCAATACAACTTATATTTTTGCAGTTTCTACTGGAAGAAAAAAGTTTTCAA TACCTAGACCAACTTGTTGAATTTTTAAAACTTATGCACTATAAATGCAACTTTCTCTACTGCTTTCTCAGTGCCTTTAGGAAGCTTTCA >In-frame_ENST00000396512_ENST00000316418_TCGA-EB-A5KH-06A_ACO2_chr22_41865186_+_AHRR_chr5_422844_length(amino acids)=585AA_start in transcript=2_stop in transcript=1759 LSVHKMAPYSLLVTRLQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRC FICRVRCLLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKP RADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLS RASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVG EDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSH PATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ACO2-AHRR |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACO2-AHRR |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ACO2-AHRR |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACO2 | C3281192 | INFANTILE CEREBELLAR-RETINAL DEGENERATION | 2 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | ACO2 | C4225384 | OPTIC ATROPHY 9 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | ACO2 | C0035222 | Respiratory Distress Syndrome, Adult | 1 | CTD_human |
Hgene | ACO2 | C2239176 | Liver carcinoma | 1 | CTD_human |