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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDC42-RNF14 (FusionGDB2 ID:14879)

Fusion Gene Summary for CDC42-RNF14

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC42-RNF14
Fusion gene ID: 14879
HgeneTgene
Gene symbol

CDC42

RNF14

Gene ID

998

9604

Gene namecell division cycle 42ring finger protein 14
SynonymsCDC42Hs|G25K|TKSARA54|HFB30|HRIHFB2038|TRIAD2
Cytomap

1p36.12

5q31.3

Type of geneprotein-codingprotein-coding
Descriptioncell division control protein 42 homologG25K GTP-binding proteinGTP binding protein, 25kDadJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))growth-regulating proteinsmall E3 ubiquitin-protein ligase RNF14androgen receptor associated protein 54
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000400259, ENST00000344548, 
ENST00000315554, ENST00000498236, 
ENST00000421089, 		ENST00000356143, 
ENST00000394520, ENST00000347642, 
ENST00000540015, ENST00000502341, 
ENST00000394514, ENST00000394515, 
ENST00000394519, 
Fusion gene scores* DoF score12 X 9 X 6=6482 X 2 X 2=8
# samples 132
** MAII scorelog2(13/648*10)=-2.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: CDC42 [Title/Abstract] AND RNF14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDC42(22419099)-RNF14(141359696), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC42

GO:0030036

actin cytoskeleton organization

11035016

HgeneCDC42

GO:0031274

positive regulation of pseudopodium assembly

11035016

HgeneCDC42

GO:0051489

regulation of filopodium assembly

14978216

HgeneCDC42

GO:1900026

positive regulation of substrate adhesion-dependent cell spreading

11807099

TgeneRNF14

GO:0006355

regulation of transcription, DNA-templated

19345326

TgeneRNF14

GO:0045893

positive regulation of transcription, DNA-templated

19345326

TgeneRNF14

GO:0060765

regulation of androgen receptor signaling pathway

19345326


check buttonFusion gene breakpoints across CDC42 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RNF14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW960726CDC42chr1

22419099

+RNF14chr5

141359696

+


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Fusion Gene ORF analysis for CDC42-RNF14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000400259ENST00000356143CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-3CDSENST00000400259ENST00000394520CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-3CDSENST00000400259ENST00000347642CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-intronENST00000400259ENST00000540015CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-intronENST00000400259ENST00000502341CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-intronENST00000400259ENST00000394514CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-intronENST00000400259ENST00000394515CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-intronENST00000400259ENST00000394519CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-3CDSENST00000344548ENST00000356143CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-3CDSENST00000344548ENST00000394520CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-3CDSENST00000344548ENST00000347642CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-intronENST00000344548ENST00000540015CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-intronENST00000344548ENST00000502341CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-intronENST00000344548ENST00000394514CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-intronENST00000344548ENST00000394515CDC42chr1

22419099

+RNF14chr5

141359696

+
3UTR-intronENST00000344548ENST00000394519CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-3CDSENST00000315554ENST00000356143CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-3CDSENST00000315554ENST00000394520CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-3CDSENST00000315554ENST00000347642CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000315554ENST00000540015CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000315554ENST00000502341CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000315554ENST00000394514CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000315554ENST00000394515CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000315554ENST00000394519CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-3CDSENST00000498236ENST00000356143CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-3CDSENST00000498236ENST00000394520CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-3CDSENST00000498236ENST00000347642CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000498236ENST00000540015CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000498236ENST00000502341CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000498236ENST00000394514CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000498236ENST00000394515CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000498236ENST00000394519CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-3CDSENST00000421089ENST00000356143CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-3CDSENST00000421089ENST00000394520CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-3CDSENST00000421089ENST00000347642CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000421089ENST00000540015CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000421089ENST00000502341CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000421089ENST00000394514CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000421089ENST00000394515CDC42chr1

22419099

+RNF14chr5

141359696

+
intron-intronENST00000421089ENST00000394519CDC42chr1

22419099

+RNF14chr5

141359696

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CDC42-RNF14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDC42-RNF14


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CDC42-RNF14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CDC42-RNF14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDC42-RNF14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDC42-RNF14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDC42C0036341Schizophrenia4PSYGENET
HgeneCDC42C4225222TAKENOUCHI-KOSAKI SYNDROME3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneCDC42C0001624Adrenal Gland Neoplasms1CTD_human
HgeneCDC42C0005818Blood Platelet Disorders1GENOMICS_ENGLAND
HgeneCDC42C0007097Carcinoma1CTD_human
HgeneCDC42C0019693HIV Infections1CTD_human
HgeneCDC42C0024667Animal Mammary Neoplasms1CTD_human
HgeneCDC42C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneCDC42C0027540Necrosis1CTD_human
HgeneCDC42C0205696Anaplastic carcinoma1CTD_human
HgeneCDC42C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneCDC42C0205698Undifferentiated carcinoma1CTD_human
HgeneCDC42C0205699Carcinomatosis1CTD_human
HgeneCDC42C0750887Adrenal Cancer1CTD_human
HgeneCDC42C1257925Mammary Carcinoma, Animal1CTD_human
HgeneCDC42C3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneCDC42C4505456HIV Coinfection1CTD_human