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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDH13-WFDC1 (FusionGDB2 ID:15071)

Fusion Gene Summary for CDH13-WFDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CDH13-WFDC1
Fusion gene ID: 15071
HgeneTgene
Gene symbol

CDH13

WFDC1

Gene ID

1012

58189

Gene namecadherin 13WAP four-disulfide core domain 1
SynonymsCDHH|P105PS20
Cytomap

16q23.3

16q24.1

Type of geneprotein-codingprotein-coding
Descriptioncadherin-13H-cadherin (heart)T-cadT-cadherincadherin 13, H-cadherin (heart)heart cadherinWAP four-disulfide core domain protein 1WAP four-disulfide core domain 1 homologprostate stromal protein ps20ps20 growth inhibitor
Modification date2020031520200313
UniProtAcc

P55290

.
Ensembl transtripts involved in fusion geneENST00000566620, ENST00000268613, 
ENST00000565636, ENST00000431540, 
ENST00000428848, ENST00000567445, 
ENST00000446376, ENST00000569454, 
ENST00000219454, ENST00000568638, 
Fusion gene scores* DoF score15 X 15 X 4=9002 X 2 X 2=8
# samples 173
** MAII scorelog2(17/900*10)=-2.40439025507934
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: CDH13 [Title/Abstract] AND WFDC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDH13(83520260)-WFDC1(84358025), # samples:2
CDH13(83520260)-WFDC1(84358024), # samples:2
Anticipated loss of major functional domain due to fusion event.CDH13-WFDC1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CDH13-WFDC1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDH13

GO:0002040

sprouting angiogenesis

16873731

HgeneCDH13

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

10601632

HgeneCDH13

GO:0007162

negative regulation of cell adhesion

14729458

HgeneCDH13

GO:0008285

negative regulation of cell proliferation

10737605

HgeneCDH13

GO:0016339

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

10601632

HgeneCDH13

GO:0030032

lamellipodium assembly

15703273

HgeneCDH13

GO:0030335

positive regulation of cell migration

14729458

HgeneCDH13

GO:0043542

endothelial cell migration

14729458

HgeneCDH13

GO:0043616

keratinocyte proliferation

15816843

HgeneCDH13

GO:0050850

positive regulation of calcium-mediated signaling

16013438

HgeneCDH13

GO:0050927

positive regulation of positive chemotaxis

16013438

HgeneCDH13

GO:0055096

low-density lipoprotein particle mediated signaling

16013438


check buttonFusion gene breakpoints across CDH13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across WFDC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A6FA-01ACDH13chr16

83520260

+WFDC1chr16

84358025

+
ChimerDB4ESCATCGA-JY-A6FACDH13chr16

83520260

+WFDC1chr16

84358024

+
ChimerDB4ESCATCGA-JY-A6FACDH13chr16

83520260

+WFDC1chr16

84358024

+
ChimerDB4ESCATCGA-JY-A6FACDH13chr16

83520260

+WFDC1chr16

84358025

+


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Fusion Gene ORF analysis for CDH13-WFDC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000566620ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
Frame-shiftENST00000566620ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
Frame-shiftENST00000268613ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
Frame-shiftENST00000268613ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000565636ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000565636ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000431540ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000431540ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
Frame-shiftENST00000428848ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
Frame-shiftENST00000428848ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000567445ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000567445ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000446376ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
intron-3CDSENST00000446376ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
In-frameENST00000569454ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358025

+
In-frameENST00000569454ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358025

+
Frame-shiftENST00000566620ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358024

+
Frame-shiftENST00000566620ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358024

+
Frame-shiftENST00000268613ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358024

+
Frame-shiftENST00000268613ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358024

+
intron-3CDSENST00000565636ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358024

+
intron-3CDSENST00000565636ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358024

+
intron-3CDSENST00000431540ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358024

+
intron-3CDSENST00000431540ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358024

+
Frame-shiftENST00000428848ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358024

+
Frame-shiftENST00000428848ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358024

+
intron-3CDSENST00000567445ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358024

+
intron-3CDSENST00000567445ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358024

+
intron-3CDSENST00000446376ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358024

+
intron-3CDSENST00000446376ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358024

+
In-frameENST00000569454ENST00000219454CDH13chr16

83520260

+WFDC1chr16

84358024

+
In-frameENST00000569454ENST00000568638CDH13chr16

83520260

+WFDC1chr16

84358024

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000569454CDH13chr1683520260+ENST00000219454WFDC1chr1684358025+15168777996329
ENST00000569454CDH13chr1683520260+ENST00000568638WFDC1chr1684358025+150887771023338
ENST00000569454CDH13chr1683520260+ENST00000219454WFDC1chr1684358024+15168777996329
ENST00000569454CDH13chr1683520260+ENST00000568638WFDC1chr1684358024+150887771023338

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000569454ENST00000219454CDH13chr1683520260+WFDC1chr1684358025+0.0011030560.99889696
ENST00000569454ENST00000568638CDH13chr1683520260+WFDC1chr1684358025+0.0010386090.9989613
ENST00000569454ENST00000219454CDH13chr1683520260+WFDC1chr1684358024+0.0011030560.99889696
ENST00000569454ENST00000568638CDH13chr1683520260+WFDC1chr1684358024+0.0010386090.9989613

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Fusion Genomic Features for CDH13-WFDC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDH13chr1683520260+WFDC1chr1684358024+0.0006348540.99936515
CDH13chr1683520260+WFDC1chr1684358024+0.0006348540.99936515
CDH13chr1683520260+WFDC1chr1684358024+0.0006348540.99936515
CDH13chr1683520260+WFDC1chr1684358024+0.0006348540.99936515

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDH13-WFDC1


check button Go to

FGviewer for the breakpoints of chr16:83520260-chr16:84358025

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDH13

P55290

.
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. {ECO:0000269|PubMed:10737605}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH13chr16:83520260chr16:84358024ENST00000268613+815139_245367.0761.0DomainCadherin 1
HgeneCDH13chr16:83520260chr16:84358024ENST00000268613+815246_363367.0761.0DomainCadherin 2
HgeneCDH13chr16:83520260chr16:84358024ENST00000566620+714139_245320.0714.0DomainCadherin 1
HgeneCDH13chr16:83520260chr16:84358025ENST00000268613+815139_245367.0761.0DomainCadherin 1
HgeneCDH13chr16:83520260chr16:84358025ENST00000268613+815246_363367.0761.0DomainCadherin 2
HgeneCDH13chr16:83520260chr16:84358025ENST00000566620+714139_245320.0714.0DomainCadherin 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH13chr16:83520260chr16:84358024ENST00000268613+815364_477367.0761.0DomainCadherin 3
HgeneCDH13chr16:83520260chr16:84358024ENST00000268613+815478_585367.0761.0DomainCadherin 4
HgeneCDH13chr16:83520260chr16:84358024ENST00000268613+815584_694367.0761.0DomainCadherin 5
HgeneCDH13chr16:83520260chr16:84358024ENST00000431540+15139_2450191.0DomainCadherin 1
HgeneCDH13chr16:83520260chr16:84358024ENST00000431540+15246_3630191.0DomainCadherin 2
HgeneCDH13chr16:83520260chr16:84358024ENST00000431540+15364_4770191.0DomainCadherin 3
HgeneCDH13chr16:83520260chr16:84358024ENST00000431540+15478_5850191.0DomainCadherin 4
HgeneCDH13chr16:83520260chr16:84358024ENST00000431540+15584_6940191.0DomainCadherin 5
HgeneCDH13chr16:83520260chr16:84358024ENST00000446376+15139_2450.0176.0DomainCadherin 1
HgeneCDH13chr16:83520260chr16:84358024ENST00000446376+15246_3630.0176.0DomainCadherin 2
HgeneCDH13chr16:83520260chr16:84358024ENST00000446376+15364_4770.0176.0DomainCadherin 3
HgeneCDH13chr16:83520260chr16:84358024ENST00000446376+15478_5850.0176.0DomainCadherin 4
HgeneCDH13chr16:83520260chr16:84358024ENST00000446376+15584_6940.0176.0DomainCadherin 5
HgeneCDH13chr16:83520260chr16:84358024ENST00000565636+16139_2450171.33333333333334DomainCadherin 1
HgeneCDH13chr16:83520260chr16:84358024ENST00000565636+16246_3630171.33333333333334DomainCadherin 2
HgeneCDH13chr16:83520260chr16:84358024ENST00000565636+16364_4770171.33333333333334DomainCadherin 3
HgeneCDH13chr16:83520260chr16:84358024ENST00000565636+16478_5850171.33333333333334DomainCadherin 4
HgeneCDH13chr16:83520260chr16:84358024ENST00000565636+16584_6940171.33333333333334DomainCadherin 5
HgeneCDH13chr16:83520260chr16:84358024ENST00000566620+714246_363320.0714.0DomainCadherin 2
HgeneCDH13chr16:83520260chr16:84358024ENST00000566620+714364_477320.0714.0DomainCadherin 3
HgeneCDH13chr16:83520260chr16:84358024ENST00000566620+714478_585320.0714.0DomainCadherin 4
HgeneCDH13chr16:83520260chr16:84358024ENST00000566620+714584_694320.0714.0DomainCadherin 5
HgeneCDH13chr16:83520260chr16:84358025ENST00000268613+815364_477367.0761.0DomainCadherin 3
HgeneCDH13chr16:83520260chr16:84358025ENST00000268613+815478_585367.0761.0DomainCadherin 4
HgeneCDH13chr16:83520260chr16:84358025ENST00000268613+815584_694367.0761.0DomainCadherin 5
HgeneCDH13chr16:83520260chr16:84358025ENST00000431540+15139_2450191.0DomainCadherin 1
HgeneCDH13chr16:83520260chr16:84358025ENST00000431540+15246_3630191.0DomainCadherin 2
HgeneCDH13chr16:83520260chr16:84358025ENST00000431540+15364_4770191.0DomainCadherin 3
HgeneCDH13chr16:83520260chr16:84358025ENST00000431540+15478_5850191.0DomainCadherin 4
HgeneCDH13chr16:83520260chr16:84358025ENST00000431540+15584_6940191.0DomainCadherin 5
HgeneCDH13chr16:83520260chr16:84358025ENST00000446376+15139_2450.0176.0DomainCadherin 1
HgeneCDH13chr16:83520260chr16:84358025ENST00000446376+15246_3630.0176.0DomainCadherin 2
HgeneCDH13chr16:83520260chr16:84358025ENST00000446376+15364_4770.0176.0DomainCadherin 3
HgeneCDH13chr16:83520260chr16:84358025ENST00000446376+15478_5850.0176.0DomainCadherin 4
HgeneCDH13chr16:83520260chr16:84358025ENST00000446376+15584_6940.0176.0DomainCadherin 5
HgeneCDH13chr16:83520260chr16:84358025ENST00000565636+16139_2450171.33333333333334DomainCadherin 1
HgeneCDH13chr16:83520260chr16:84358025ENST00000565636+16246_3630171.33333333333334DomainCadherin 2
HgeneCDH13chr16:83520260chr16:84358025ENST00000565636+16364_4770171.33333333333334DomainCadherin 3
HgeneCDH13chr16:83520260chr16:84358025ENST00000565636+16478_5850171.33333333333334DomainCadherin 4
HgeneCDH13chr16:83520260chr16:84358025ENST00000565636+16584_6940171.33333333333334DomainCadherin 5
HgeneCDH13chr16:83520260chr16:84358025ENST00000566620+714246_363320.0714.0DomainCadherin 2
HgeneCDH13chr16:83520260chr16:84358025ENST00000566620+714364_477320.0714.0DomainCadherin 3
HgeneCDH13chr16:83520260chr16:84358025ENST00000566620+714478_585320.0714.0DomainCadherin 4
HgeneCDH13chr16:83520260chr16:84358025ENST00000566620+714584_694320.0714.0DomainCadherin 5
TgeneWFDC1chr16:83520260chr16:84358024ENST0000021945437109_112187.33333333333334238.66666666666666Compositional biasNote=Poly-Pro
TgeneWFDC1chr16:83520260chr16:84358024ENST000002194543767_70187.33333333333334238.66666666666666Compositional biasNote=Poly-Pro
TgeneWFDC1chr16:83520260chr16:84358024ENST0000056863837109_112187.33333333333334302.6666666666667Compositional biasNote=Poly-Pro
TgeneWFDC1chr16:83520260chr16:84358024ENST000005686383767_70187.33333333333334302.6666666666667Compositional biasNote=Poly-Pro
TgeneWFDC1chr16:83520260chr16:84358025ENST0000021945437109_112187.33333333333334238.66666666666666Compositional biasNote=Poly-Pro
TgeneWFDC1chr16:83520260chr16:84358025ENST000002194543767_70187.33333333333334238.66666666666666Compositional biasNote=Poly-Pro
TgeneWFDC1chr16:83520260chr16:84358025ENST0000056863837109_112187.33333333333334302.6666666666667Compositional biasNote=Poly-Pro
TgeneWFDC1chr16:83520260chr16:84358025ENST000005686383767_70187.33333333333334302.6666666666667Compositional biasNote=Poly-Pro
TgeneWFDC1chr16:83520260chr16:84358024ENST000002194543759_108187.33333333333334238.66666666666666DomainWAP
TgeneWFDC1chr16:83520260chr16:84358024ENST000005686383759_108187.33333333333334302.6666666666667DomainWAP
TgeneWFDC1chr16:83520260chr16:84358025ENST000002194543759_108187.33333333333334238.66666666666666DomainWAP
TgeneWFDC1chr16:83520260chr16:84358025ENST000005686383759_108187.33333333333334302.6666666666667DomainWAP


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Fusion Gene Sequence for CDH13-WFDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000569454_ENST00000219454_TCGA-JY-A6FA-01A_CDH13_chr16_83520260_+_WFDC1_chr16_84358025_length(transcript)=1516nt_BP=877nt
AGCAGAGCTGCCAACCAGAGCCTCTGATCAACACAGGATAACCAGCAGGAGAGTTGGTGGAATTCCAGACAGTGTGACCTTCAGTGACTG
TAAGGGAAACGACAAGCTACGCTATGAGGTCTCGAGCCCATACTTCAAGGTGAACAGCGATGGCGGCTTAGTTGCTCTGAGAAACATAAC
TGCAGTGGGCAAAACTCTGTTCGTCCATGCACGGACCCCCCATGCGGAAGATATGGCAGAACTCGTGATTGTCGGGGGGAAAGACATCCA
GGGCTCCTTGCAGGATATATTTAAATTTGCAAGAACTTCTCCTGTCCCAAGACAAAAGAGGTCCATTGTGGTATCTCCCATTTTAATTCC
AGAGAATCAGAGACAGCCTTTCCCAAGAGATGTTGGCAAGGTAGTCGATAGTGACAGGCCAGAAAGGTCCAAGTTCCGGCTCACTGGAAA
GGGAGTGGATCAAGAGCCTAAAGGAATTTTCAGAATCAATGAGAACACAGGGAGCGTCTCCGTGACACGGACCTTGGACAGAGAAGTAAT
CGCTGTTTATCAACTATTTGTGGAGACCACTGATGTCAATGGCAAAACTCTCGAGGGGCCGGTGCCTCTGGAAGTCATTGTGATTGATCA
GAATGACAACCGACCGATCTTTCGGGAAGGCCCCTACATCGGCCACGTCATGGAAGGGTCACCCACAGGCACCACAGTGATGCGGATGAC
AGCCTTTGATGCAGATGACCCAGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACAT
GTTCTACATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAGATGGGCGAATCCTACGACACAAA
CTTTACAAAGAATATCCAGAAGGTGACTCAAAGAATGTGGCAGAACCTGGAAGGGGACAACAGAAGCACTTTCAGTAAAGCAACGGCAAG
CAGCTAGGTTGCAAGAACATTCCTCTACTTTCTGCTAAGCCTTGGAAACAGTTGGGAAAAGTAGTTTGACCCTCACAGTTCACATTCAGC
TCAGCAGAGCAAGACCCCAGAGATGCTTAGAGACAGGACACCTGGCCATCAAACCCAGTTTGGCCCAGCCTGGTTGGGTGACTTTGTGGG
AGCCACTTAACAGCTCTGGGTCCCTGTTTTACCATCCTGGGAGCAAGGCCCTGCAGCTCCACGAGACCTTTACCCCGGGAAGAAGCCGCC
ACCCATGAAAGCATTTCTGAAGCCCCTTTCTAAGACAAGGCTCAGCATCTTGATATTTTTGACAGATTCCTCCCAAGTCTGGCTCTGGGA
GGTATGTACCCATCTCAAATGTTCCCAAGATAAATTCATCCTTCAGGAAATGGAAATGAACTTGCTTACTAATGTGTGATTCCTAGTTGT

>In-frame_ENST00000569454_ENST00000219454_TCGA-JY-A6FA-01A_CDH13_chr16_83520260_+_WFDC1_chr16_84358025_length(amino acids)=329AA_start in transcript=7_stop in transcript=996
MPTRASDQHRITSRRVGGIPDSVTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGKTLFVHARTPHAEDMAELVIVGGKDIQGS
LQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPERSKFRLTGKGVDQEPKGIFRINENTGSVSVTRTLDREVIAV
YQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFY

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>In-frame_ENST00000569454_ENST00000568638_TCGA-JY-A6FA-01A_CDH13_chr16_83520260_+_WFDC1_chr16_84358025_length(transcript)=1508nt_BP=877nt
AGCAGAGCTGCCAACCAGAGCCTCTGATCAACACAGGATAACCAGCAGGAGAGTTGGTGGAATTCCAGACAGTGTGACCTTCAGTGACTG
TAAGGGAAACGACAAGCTACGCTATGAGGTCTCGAGCCCATACTTCAAGGTGAACAGCGATGGCGGCTTAGTTGCTCTGAGAAACATAAC
TGCAGTGGGCAAAACTCTGTTCGTCCATGCACGGACCCCCCATGCGGAAGATATGGCAGAACTCGTGATTGTCGGGGGGAAAGACATCCA
GGGCTCCTTGCAGGATATATTTAAATTTGCAAGAACTTCTCCTGTCCCAAGACAAAAGAGGTCCATTGTGGTATCTCCCATTTTAATTCC
AGAGAATCAGAGACAGCCTTTCCCAAGAGATGTTGGCAAGGTAGTCGATAGTGACAGGCCAGAAAGGTCCAAGTTCCGGCTCACTGGAAA
GGGAGTGGATCAAGAGCCTAAAGGAATTTTCAGAATCAATGAGAACACAGGGAGCGTCTCCGTGACACGGACCTTGGACAGAGAAGTAAT
CGCTGTTTATCAACTATTTGTGGAGACCACTGATGTCAATGGCAAAACTCTCGAGGGGCCGGTGCCTCTGGAAGTCATTGTGATTGATCA
GAATGACAACCGACCGATCTTTCGGGAAGGCCCCTACATCGGCCACGTCATGGAAGGGTCACCCACAGGCACCACAGTGATGCGGATGAC
AGCCTTTGATGCAGATGACCCAGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACAT
GTTCTACATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAGATGGGCGAATCCTACGACACAAA
CTTTACAAAGAATATCCAGAAGGTGACTCAAAGAATGTGGCAGAACCTGGAAGGGGACAACAGAAGCACTTTCAGTAAAGCAACGGCAAG
CAGGTTGCAAGAACATTCCTCTACTTTCTGCTAAGCCTTGGAAACAGTTGGGAAAAGTAGTTTGACCCTCACAGTTCACATTCAGCTCAG
CAGAGCAAGACCCCAGAGATGCTTAGAGACAGGACACCTGGCCATCAAACCCAGTTTGGCCCAGCCTGGTTGGGTGACTTTGTGGGAGCC
ACTTAACAGCTCTGGGTCCCTGTTTTACCATCCTGGGAGCAAGGCCCTGCAGCTCCACGAGACCTTTACCCCGGGAAGAAGCCGCCACCC
ATGAAAGCATTTCTGAAGCCCCTTTCTAAGACAAGGCTCAGCATCTTGATATTTTTGACAGATTCCTCCCAAGTCTGGCTCTGGGAGGTA
TGTACCCATCTCAAATGTTCCCAAGATAAATTCATCCTTCAGGAAATGGAAATGAACTTGCTTACTAATGTGTGATTCCTAGTTGTAGCC

>In-frame_ENST00000569454_ENST00000568638_TCGA-JY-A6FA-01A_CDH13_chr16_83520260_+_WFDC1_chr16_84358025_length(amino acids)=338AA_start in transcript=7_stop in transcript=1023
MPTRASDQHRITSRRVGGIPDSVTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGKTLFVHARTPHAEDMAELVIVGGKDIQGS
LQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPERSKFRLTGKGVDQEPKGIFRINENTGSVSVTRTLDREVIAV
YQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFY

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>In-frame_ENST00000569454_ENST00000219454_TCGA-JY-A6FA_CDH13_chr16_83520260_+_WFDC1_chr16_84358024_length(transcript)=1516nt_BP=877nt
AGCAGAGCTGCCAACCAGAGCCTCTGATCAACACAGGATAACCAGCAGGAGAGTTGGTGGAATTCCAGACAGTGTGACCTTCAGTGACTG
TAAGGGAAACGACAAGCTACGCTATGAGGTCTCGAGCCCATACTTCAAGGTGAACAGCGATGGCGGCTTAGTTGCTCTGAGAAACATAAC
TGCAGTGGGCAAAACTCTGTTCGTCCATGCACGGACCCCCCATGCGGAAGATATGGCAGAACTCGTGATTGTCGGGGGGAAAGACATCCA
GGGCTCCTTGCAGGATATATTTAAATTTGCAAGAACTTCTCCTGTCCCAAGACAAAAGAGGTCCATTGTGGTATCTCCCATTTTAATTCC
AGAGAATCAGAGACAGCCTTTCCCAAGAGATGTTGGCAAGGTAGTCGATAGTGACAGGCCAGAAAGGTCCAAGTTCCGGCTCACTGGAAA
GGGAGTGGATCAAGAGCCTAAAGGAATTTTCAGAATCAATGAGAACACAGGGAGCGTCTCCGTGACACGGACCTTGGACAGAGAAGTAAT
CGCTGTTTATCAACTATTTGTGGAGACCACTGATGTCAATGGCAAAACTCTCGAGGGGCCGGTGCCTCTGGAAGTCATTGTGATTGATCA
GAATGACAACCGACCGATCTTTCGGGAAGGCCCCTACATCGGCCACGTCATGGAAGGGTCACCCACAGGCACCACAGTGATGCGGATGAC
AGCCTTTGATGCAGATGACCCAGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACAT
GTTCTACATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAGATGGGCGAATCCTACGACACAAA
CTTTACAAAGAATATCCAGAAGGTGACTCAAAGAATGTGGCAGAACCTGGAAGGGGACAACAGAAGCACTTTCAGTAAAGCAACGGCAAG
CAGCTAGGTTGCAAGAACATTCCTCTACTTTCTGCTAAGCCTTGGAAACAGTTGGGAAAAGTAGTTTGACCCTCACAGTTCACATTCAGC
TCAGCAGAGCAAGACCCCAGAGATGCTTAGAGACAGGACACCTGGCCATCAAACCCAGTTTGGCCCAGCCTGGTTGGGTGACTTTGTGGG
AGCCACTTAACAGCTCTGGGTCCCTGTTTTACCATCCTGGGAGCAAGGCCCTGCAGCTCCACGAGACCTTTACCCCGGGAAGAAGCCGCC
ACCCATGAAAGCATTTCTGAAGCCCCTTTCTAAGACAAGGCTCAGCATCTTGATATTTTTGACAGATTCCTCCCAAGTCTGGCTCTGGGA
GGTATGTACCCATCTCAAATGTTCCCAAGATAAATTCATCCTTCAGGAAATGGAAATGAACTTGCTTACTAATGTGTGATTCCTAGTTGT

>In-frame_ENST00000569454_ENST00000219454_TCGA-JY-A6FA_CDH13_chr16_83520260_+_WFDC1_chr16_84358024_length(amino acids)=329AA_start in transcript=7_stop in transcript=996
MPTRASDQHRITSRRVGGIPDSVTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGKTLFVHARTPHAEDMAELVIVGGKDIQGS
LQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPERSKFRLTGKGVDQEPKGIFRINENTGSVSVTRTLDREVIAV
YQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFY

--------------------------------------------------------------
>In-frame_ENST00000569454_ENST00000568638_TCGA-JY-A6FA_CDH13_chr16_83520260_+_WFDC1_chr16_84358024_length(transcript)=1508nt_BP=877nt
AGCAGAGCTGCCAACCAGAGCCTCTGATCAACACAGGATAACCAGCAGGAGAGTTGGTGGAATTCCAGACAGTGTGACCTTCAGTGACTG
TAAGGGAAACGACAAGCTACGCTATGAGGTCTCGAGCCCATACTTCAAGGTGAACAGCGATGGCGGCTTAGTTGCTCTGAGAAACATAAC
TGCAGTGGGCAAAACTCTGTTCGTCCATGCACGGACCCCCCATGCGGAAGATATGGCAGAACTCGTGATTGTCGGGGGGAAAGACATCCA
GGGCTCCTTGCAGGATATATTTAAATTTGCAAGAACTTCTCCTGTCCCAAGACAAAAGAGGTCCATTGTGGTATCTCCCATTTTAATTCC
AGAGAATCAGAGACAGCCTTTCCCAAGAGATGTTGGCAAGGTAGTCGATAGTGACAGGCCAGAAAGGTCCAAGTTCCGGCTCACTGGAAA
GGGAGTGGATCAAGAGCCTAAAGGAATTTTCAGAATCAATGAGAACACAGGGAGCGTCTCCGTGACACGGACCTTGGACAGAGAAGTAAT
CGCTGTTTATCAACTATTTGTGGAGACCACTGATGTCAATGGCAAAACTCTCGAGGGGCCGGTGCCTCTGGAAGTCATTGTGATTGATCA
GAATGACAACCGACCGATCTTTCGGGAAGGCCCCTACATCGGCCACGTCATGGAAGGGTCACCCACAGGCACCACAGTGATGCGGATGAC
AGCCTTTGATGCAGATGACCCAGCCACCGATAATGCCCTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACAT
GTTCTACATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAGATGGGCGAATCCTACGACACAAA
CTTTACAAAGAATATCCAGAAGGTGACTCAAAGAATGTGGCAGAACCTGGAAGGGGACAACAGAAGCACTTTCAGTAAAGCAACGGCAAG
CAGGTTGCAAGAACATTCCTCTACTTTCTGCTAAGCCTTGGAAACAGTTGGGAAAAGTAGTTTGACCCTCACAGTTCACATTCAGCTCAG
CAGAGCAAGACCCCAGAGATGCTTAGAGACAGGACACCTGGCCATCAAACCCAGTTTGGCCCAGCCTGGTTGGGTGACTTTGTGGGAGCC
ACTTAACAGCTCTGGGTCCCTGTTTTACCATCCTGGGAGCAAGGCCCTGCAGCTCCACGAGACCTTTACCCCGGGAAGAAGCCGCCACCC
ATGAAAGCATTTCTGAAGCCCCTTTCTAAGACAAGGCTCAGCATCTTGATATTTTTGACAGATTCCTCCCAAGTCTGGCTCTGGGAGGTA
TGTACCCATCTCAAATGTTCCCAAGATAAATTCATCCTTCAGGAAATGGAAATGAACTTGCTTACTAATGTGTGATTCCTAGTTGTAGCC

>In-frame_ENST00000569454_ENST00000568638_TCGA-JY-A6FA_CDH13_chr16_83520260_+_WFDC1_chr16_84358024_length(amino acids)=338AA_start in transcript=7_stop in transcript=1023
MPTRASDQHRITSRRVGGIPDSVTFSDCKGNDKLRYEVSSPYFKVNSDGGLVALRNITAVGKTLFVHARTPHAEDMAELVIVGGKDIQGS
LQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPERSKFRLTGKGVDQEPKGIFRINENTGSVSVTRTLDREVIAV
YQLFVETTDVNGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFY

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Fusion Gene PPI Analysis for CDH13-WFDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDH13-WFDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDH13-WFDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDH13C0001973Alcoholic Intoxication, Chronic3PSYGENET
HgeneCDH13C2239176Liver carcinoma3CTD_human
HgeneCDH13C0033578Prostatic Neoplasms2CTD_human
HgeneCDH13C0376358Malignant neoplasm of prostate2CTD_human
HgeneCDH13C0004763Barrett Esophagus1CTD_human
HgeneCDH13C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneCDH13C0011570Mental Depression1PSYGENET
HgeneCDH13C0011581Depressive disorder1PSYGENET
HgeneCDH13C0013146Drug abuse1CTD_human
HgeneCDH13C0013170Drug habituation1CTD_human
HgeneCDH13C0013222Drug Use Disorders1CTD_human
HgeneCDH13C0014859Esophageal Neoplasms1CTD_human
HgeneCDH13C0024121Lung Neoplasms1CTD_human
HgeneCDH13C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneCDH13C0038580Substance Dependence1CTD_human
HgeneCDH13C0038586Substance Use Disorders1CTD_human
HgeneCDH13C0236733Amphetamine-Related Disorders1CTD_human
HgeneCDH13C0236804Amphetamine Addiction1CTD_human
HgeneCDH13C0236807Amphetamine Abuse1CTD_human
HgeneCDH13C0236969Substance-Related Disorders1CTD_human
HgeneCDH13C0242379Malignant neoplasm of lung1CTD_human
HgeneCDH13C0546837Malignant neoplasm of esophagus1CTD_human
HgeneCDH13C0740858Substance abuse problem1CTD_human
HgeneCDH13C1258085Barrett Epithelium1CTD_human
HgeneCDH13C1510472Drug Dependence1CTD_human
HgeneCDH13C4316881Prescription Drug Abuse1CTD_human
TgeneWFDC1C0025202melanoma1CTD_human