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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ACOT7-PLEKHG5 (FusionGDB2 ID:1510)

Fusion Gene Summary for ACOT7-PLEKHG5

Fusion gene summary

Fusion gene information	Fusion gene name: ACOT7-PLEKHG5
	Fusion gene ID: 1510
		Hgene	Tgene
	Gene symbol	ACOT7	PLEKHG5
	Gene ID	11332	57449
	Gene name	acyl-CoA thioesterase 7	pleckstrin homology and RhoGEF domain containing G5
	Synonyms	ACH1\|ACT\|BACH\|CTE-II\|LACH\|LACH1\|hBACH	CMTRIC\|DSMA4\|GEF720\|Syx\|Tech
	Cytomap	1p36.31	1p36.31
	Type of gene	protein-coding	protein-coding
	Description	cytosolic acyl coenzyme A thioester hydrolaseCTE-IIaacyl-CoA thioesterase 2acyl-CoA thioesterase, long chainbrain acyl-CoA hydrolaselong chain acyl-CoA thioester hydrolase	pleckstrin homology domain-containing family G member 5NFkB activating proteinPH domain-containing family G member 5guanine nucleotide exchange factor 720novel PH domain-containing proteinpleckstrin homology domain containing, family G (with RhoGef d
	Modification date	20200313	20200320
	UniProtAcc	O00154	.
	Ensembl transtripts involved in fusion gene	ENST00000608083, ENST00000377855, ENST00000545482, ENST00000361521, ENST00000377842, ENST00000377845, ENST00000541130,	ENST00000377748, ENST00000377732, ENST00000400915, ENST00000377740, ENST00000377737, ENST00000537245, ENST00000544978, ENST00000400913, ENST00000340850, ENST00000377725, ENST00000377728, ENST00000535355,
Fusion gene scores	* DoF score	15 X 10 X 10=1500	4 X 3 X 4=48
	# samples	20	6
	** MAII score	log2(20/1500*10)=-2.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ACOT7 [Title/Abstract] AND PLEKHG5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ACOT7(6341162)-PLEKHG5(6556629), # samples:5
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ACOT7	GO:0015937	coenzyme A biosynthetic process	10578051
Hgene	ACOT7	GO:0036114	medium-chain fatty-acyl-CoA catabolic process	10578051
Hgene	ACOT7	GO:0036116	long-chain fatty-acyl-CoA catabolic process	10578051
Hgene	ACOT7	GO:0051792	medium-chain fatty acid biosynthetic process	10578051
Hgene	ACOT7	GO:1900535	palmitic acid biosynthetic process	10578051

Fusion gene breakpoints across ACOT7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PLEKHG5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A4OS-01A	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
ChimerDB4	STAD	TCGA-VQ-A925-01A	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
ChimerDB4	ESCA	TCGA-L5-A4OS	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
ChimerDB4	ESCA	TCGA-L5-A4OS	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
ChimerDB4	STAD	TCGA-VQ-A925	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
ChimerDB4	ESCA	TCGA-L5-A4OS	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
ChimerDB4	STAD	TCGA-VQ-A925-01A	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
ChimerDB4	ESCA	TCGA-L5-A4OS-01A	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-

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Fusion Gene ORF analysis for ACOT7-PLEKHG5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000608083	ENST00000377748	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000608083	ENST00000377732	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000608083	ENST00000400915	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000608083	ENST00000377740	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000608083	ENST00000377737	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000608083	ENST00000537245	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000608083	ENST00000544978	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000608083	ENST00000400913	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000608083	ENST00000340850	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000608083	ENST00000377725	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000608083	ENST00000377728	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000608083	ENST00000535355	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
Frame-shift	ENST00000377855	ENST00000377748	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377855	ENST00000377732	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377855	ENST00000400915	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377855	ENST00000377740	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377855	ENST00000377737	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377855	ENST00000537245	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377855	ENST00000544978	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377855	ENST00000400913	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377855	ENST00000340850	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377855	ENST00000377725	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377855	ENST00000377728	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377855	ENST00000535355	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
Frame-shift	ENST00000545482	ENST00000377748	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000545482	ENST00000377732	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000545482	ENST00000400915	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000545482	ENST00000377740	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000545482	ENST00000377737	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000545482	ENST00000537245	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000545482	ENST00000544978	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000545482	ENST00000400913	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000545482	ENST00000340850	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000545482	ENST00000377725	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000545482	ENST00000377728	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000545482	ENST00000535355	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
Frame-shift	ENST00000361521	ENST00000377748	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000361521	ENST00000377732	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000361521	ENST00000400915	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000361521	ENST00000377740	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000361521	ENST00000377737	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000361521	ENST00000537245	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000361521	ENST00000544978	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000361521	ENST00000400913	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000361521	ENST00000340850	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000361521	ENST00000377725	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000361521	ENST00000377728	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000361521	ENST00000535355	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
Frame-shift	ENST00000377842	ENST00000377748	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377842	ENST00000377732	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377842	ENST00000400915	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377842	ENST00000377740	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377842	ENST00000377737	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377842	ENST00000537245	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377842	ENST00000544978	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377842	ENST00000400913	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377842	ENST00000340850	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377842	ENST00000377725	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377842	ENST00000377728	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377842	ENST00000535355	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
Frame-shift	ENST00000377845	ENST00000377748	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377845	ENST00000377732	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377845	ENST00000400915	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377845	ENST00000377740	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377845	ENST00000377737	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377845	ENST00000537245	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377845	ENST00000544978	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377845	ENST00000400913	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377845	ENST00000340850	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377845	ENST00000377725	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377845	ENST00000377728	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377845	ENST00000535355	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
intron-3CDS	ENST00000541130	ENST00000377748	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
intron-5UTR	ENST00000541130	ENST00000377732	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
intron-5UTR	ENST00000541130	ENST00000400915	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
intron-5UTR	ENST00000541130	ENST00000377740	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
intron-5UTR	ENST00000541130	ENST00000377737	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
intron-5UTR	ENST00000541130	ENST00000537245	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
intron-5UTR	ENST00000541130	ENST00000544978	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
intron-intron	ENST00000541130	ENST00000400913	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
intron-intron	ENST00000541130	ENST00000340850	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
intron-intron	ENST00000541130	ENST00000377725	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
intron-intron	ENST00000541130	ENST00000377728	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
intron-intron	ENST00000541130	ENST00000535355	ACOT7	chr1	6341162	-	PLEKHG5	chr1	6556629	-
Frame-shift	ENST00000608083	ENST00000377748	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000608083	ENST00000377732	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000608083	ENST00000400915	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000608083	ENST00000377740	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000608083	ENST00000377737	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000608083	ENST00000537245	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000608083	ENST00000544978	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000608083	ENST00000400913	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000608083	ENST00000340850	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000608083	ENST00000377725	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000608083	ENST00000377728	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000608083	ENST00000535355	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
Frame-shift	ENST00000377855	ENST00000377748	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377855	ENST00000377732	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377855	ENST00000400915	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377855	ENST00000377740	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377855	ENST00000377737	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377855	ENST00000537245	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377855	ENST00000544978	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377855	ENST00000400913	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377855	ENST00000340850	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377855	ENST00000377725	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377855	ENST00000377728	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377855	ENST00000535355	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
Frame-shift	ENST00000545482	ENST00000377748	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000545482	ENST00000377732	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000545482	ENST00000400915	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000545482	ENST00000377740	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000545482	ENST00000377737	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000545482	ENST00000537245	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000545482	ENST00000544978	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000545482	ENST00000400913	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000545482	ENST00000340850	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000545482	ENST00000377725	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000545482	ENST00000377728	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000545482	ENST00000535355	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
Frame-shift	ENST00000361521	ENST00000377748	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000361521	ENST00000377732	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000361521	ENST00000400915	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000361521	ENST00000377740	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000361521	ENST00000377737	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000361521	ENST00000537245	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000361521	ENST00000544978	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000361521	ENST00000400913	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000361521	ENST00000340850	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000361521	ENST00000377725	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000361521	ENST00000377728	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000361521	ENST00000535355	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
Frame-shift	ENST00000377842	ENST00000377748	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377842	ENST00000377732	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377842	ENST00000400915	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377842	ENST00000377740	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377842	ENST00000377737	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377842	ENST00000537245	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377842	ENST00000544978	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377842	ENST00000400913	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377842	ENST00000340850	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377842	ENST00000377725	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377842	ENST00000377728	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377842	ENST00000535355	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
Frame-shift	ENST00000377845	ENST00000377748	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377845	ENST00000377732	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377845	ENST00000400915	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377845	ENST00000377740	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377845	ENST00000377737	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377845	ENST00000537245	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-5UTR	ENST00000377845	ENST00000544978	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377845	ENST00000400913	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377845	ENST00000340850	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377845	ENST00000377725	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377845	ENST00000377728	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
5CDS-intron	ENST00000377845	ENST00000535355	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
intron-3CDS	ENST00000541130	ENST00000377748	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
intron-5UTR	ENST00000541130	ENST00000377732	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
intron-5UTR	ENST00000541130	ENST00000400915	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
intron-5UTR	ENST00000541130	ENST00000377740	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
intron-5UTR	ENST00000541130	ENST00000377737	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
intron-5UTR	ENST00000541130	ENST00000537245	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
intron-5UTR	ENST00000541130	ENST00000544978	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
intron-intron	ENST00000541130	ENST00000400913	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
intron-intron	ENST00000541130	ENST00000340850	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
intron-intron	ENST00000541130	ENST00000377725	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
intron-intron	ENST00000541130	ENST00000377728	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-
intron-intron	ENST00000541130	ENST00000535355	ACOT7	chr1	6341161	-	PLEKHG5	chr1	6556629	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ACOT7-PLEKHG5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACOT7-PLEKHG5

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ACOT7 O00154	.
FUNCTION: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:10578051). Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:10578051). May play an important physiological function in brain (PubMed:10578051). {ECO:0000269\|PubMed:10578051, ECO:0000303\|PubMed:10578051}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ACOT7-PLEKHG5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ACOT7-PLEKHG5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ACOT7-PLEKHG5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ACOT7-PLEKHG5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	PLEKHG5	C3809309	CHARCOT-MARIE-TOOTH DISEASE, RECESSIVE INTERMEDIATE C	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	PLEKHG5	C0032460	Polycystic Ovary Syndrome	1	CTD_human
Tgene	PLEKHG5	C0393541	Distal Spinal Muscular Atrophy	1	GENOMICS_ENGLAND
Tgene	PLEKHG5	C1136382	Sclerocystic Ovaries	1	CTD_human
Tgene	PLEKHG5	C1970211	Spinal Muscular Atrophy, Distal, Autosomal Recessive, 4	1	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT