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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACOT7-WIPI2 (FusionGDB2 ID:1514)

Fusion Gene Summary for ACOT7-WIPI2

check button Fusion gene summary
Fusion gene informationFusion gene name: ACOT7-WIPI2
Fusion gene ID: 1514
HgeneTgene
Gene symbol

ACOT7

WIPI2

Gene ID

11332

26100

Gene nameacyl-CoA thioesterase 7WD repeat domain, phosphoinositide interacting 2
SynonymsACH1|ACT|BACH|CTE-II|LACH|LACH1|hBACHATG18B|Atg21|CGI-50|IDDSSA|WIPI-2
Cytomap

1p36.31

7p22.1

Type of geneprotein-codingprotein-coding
Descriptioncytosolic acyl coenzyme A thioester hydrolaseCTE-IIaacyl-CoA thioesterase 2acyl-CoA thioesterase, long chainbrain acyl-CoA hydrolaselong chain acyl-CoA thioester hydrolaseWD repeat domain phosphoinositide-interacting protein 2WD40 repeat protein interacting with phosphoinositides 2WIPI49-like protein 2
Modification date2020031320200313
UniProtAcc

O00154

.
Ensembl transtripts involved in fusion geneENST00000608083, ENST00000377855, 
ENST00000545482, ENST00000361521, 
ENST00000377842, ENST00000377845, 
ENST00000541130, 		ENST00000288828, 
ENST00000401525, ENST00000404704, 
ENST00000485854, ENST00000382384, 
ENST00000484262, 
Fusion gene scores* DoF score15 X 10 X 10=15007 X 7 X 3=147
# samples 207
** MAII scorelog2(20/1500*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACOT7 [Title/Abstract] AND WIPI2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACOT7(6395699)-WIPI2(5266811), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACOT7

GO:0015937

coenzyme A biosynthetic process

10578051

HgeneACOT7

GO:0036114

medium-chain fatty-acyl-CoA catabolic process

10578051

HgeneACOT7

GO:0036116

long-chain fatty-acyl-CoA catabolic process

10578051

HgeneACOT7

GO:0051792

medium-chain fatty acid biosynthetic process

10578051

HgeneACOT7

GO:1900535

palmitic acid biosynthetic process

10578051

TgeneWIPI2

GO:0009267

cellular response to starvation

28561066


check buttonFusion gene breakpoints across ACOT7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across WIPI2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABM194349ACOT7chr1

6395699

+WIPI2chr7

5266811

+


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Fusion Gene ORF analysis for ACOT7-WIPI2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000608083ENST00000288828ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000608083ENST00000401525ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000608083ENST00000404704ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000608083ENST00000485854ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000608083ENST00000382384ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000608083ENST00000484262ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000377855ENST00000288828ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000377855ENST00000401525ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000377855ENST00000404704ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000377855ENST00000485854ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000377855ENST00000382384ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000377855ENST00000484262ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000545482ENST00000288828ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000545482ENST00000401525ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000545482ENST00000404704ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000545482ENST00000485854ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000545482ENST00000382384ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000545482ENST00000484262ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000361521ENST00000288828ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000361521ENST00000401525ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000361521ENST00000404704ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000361521ENST00000485854ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000361521ENST00000382384ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000361521ENST00000484262ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000377842ENST00000288828ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000377842ENST00000401525ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000377842ENST00000404704ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000377842ENST00000485854ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000377842ENST00000382384ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000377842ENST00000484262ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000377845ENST00000288828ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000377845ENST00000401525ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000377845ENST00000404704ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000377845ENST00000485854ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000377845ENST00000382384ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000377845ENST00000484262ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000541130ENST00000288828ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000541130ENST00000401525ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-3CDSENST00000541130ENST00000404704ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000541130ENST00000485854ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000541130ENST00000382384ACOT7chr1

6395699

+WIPI2chr7

5266811

+
intron-intronENST00000541130ENST00000484262ACOT7chr1

6395699

+WIPI2chr7

5266811

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ACOT7-WIPI2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACOT7-WIPI2


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACOT7

O00154

.
FUNCTION: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:10578051). Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:10578051). May play an important physiological function in brain (PubMed:10578051). {ECO:0000269|PubMed:10578051, ECO:0000303|PubMed:10578051}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ACOT7-WIPI2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ACOT7-WIPI2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACOT7-WIPI2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACOT7-WIPI2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource