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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDK12-FBXL20 (FusionGDB2 ID:15175)

Fusion Gene Summary for CDK12-FBXL20

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK12-FBXL20
Fusion gene ID: 15175
HgeneTgene
Gene symbol

CDK12

FBXL20

Gene ID

51755

84961

Gene namecyclin dependent kinase 12F-box and leucine rich repeat protein 20
SynonymsCRK7|CRKR|CRKRSFbl2|Fbl20
Cytomap

17q12

17q12

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12F-box/LRR-repeat protein 20F-box protein FBL2
Modification date2020031320200313
UniProtAcc

Q9NYV4

Q96IG2

Ensembl transtripts involved in fusion geneENST00000430627, ENST00000447079, 
ENST00000559545, 		ENST00000583610, 
ENST00000394294, ENST00000264658, 
ENST00000577399, 
Fusion gene scores* DoF score29 X 13 X 13=490113 X 9 X 6=702
# samples 3117
** MAII scorelog2(31/4901*10)=-3.98273602613552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/702*10)=-2.04593628416686
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDK12 [Title/Abstract] AND FBXL20 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDK12(37628016)-FBXL20(37439108), # samples:2
FBXL20(37557614)-CDK12(37657503), # samples:2
Anticipated loss of major functional domain due to fusion event.CDK12-FBXL20 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
CDK12-FBXL20 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CDK12-FBXL20 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CDK12-FBXL20 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CDK12-FBXL20 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
FBXL20-CDK12 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FBXL20-CDK12 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
FBXL20-CDK12 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
FBXL20-CDK12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
FBXL20-CDK12 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDK12

GO:0046777

protein autophosphorylation

11683387


check buttonFusion gene breakpoints across CDK12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FBXL20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A0JM-01ACDK12chr17

37628016

+FBXL20chr17

37439108

-
ChimerDB4LAMLTCGA-AB-2839-03ACDK12chr17

37628016

+FBXL20chr17

37499494

-
ChimerDB4BRCATCGA-AO-A0JM-01ACDK12chr17

37628016

-FBXL20chr17

37439108

-


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Fusion Gene ORF analysis for CDK12-FBXL20

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000430627ENST00000583610CDK12chr17

37628016

+FBXL20chr17

37439108

-
In-frameENST00000430627ENST00000394294CDK12chr17

37628016

+FBXL20chr17

37439108

-
In-frameENST00000430627ENST00000264658CDK12chr17

37628016

+FBXL20chr17

37439108

-
In-frameENST00000430627ENST00000577399CDK12chr17

37628016

+FBXL20chr17

37439108

-
In-frameENST00000447079ENST00000583610CDK12chr17

37628016

+FBXL20chr17

37439108

-
In-frameENST00000447079ENST00000394294CDK12chr17

37628016

+FBXL20chr17

37439108

-
In-frameENST00000447079ENST00000264658CDK12chr17

37628016

+FBXL20chr17

37439108

-
In-frameENST00000447079ENST00000577399CDK12chr17

37628016

+FBXL20chr17

37439108

-
intron-3CDSENST00000559545ENST00000583610CDK12chr17

37628016

+FBXL20chr17

37439108

-
intron-3CDSENST00000559545ENST00000394294CDK12chr17

37628016

+FBXL20chr17

37439108

-
intron-3CDSENST00000559545ENST00000264658CDK12chr17

37628016

+FBXL20chr17

37439108

-
intron-3CDSENST00000559545ENST00000577399CDK12chr17

37628016

+FBXL20chr17

37439108

-
Frame-shiftENST00000430627ENST00000583610CDK12chr17

37628016

+FBXL20chr17

37499494

-
Frame-shiftENST00000430627ENST00000394294CDK12chr17

37628016

+FBXL20chr17

37499494

-
Frame-shiftENST00000430627ENST00000264658CDK12chr17

37628016

+FBXL20chr17

37499494

-
Frame-shiftENST00000430627ENST00000577399CDK12chr17

37628016

+FBXL20chr17

37499494

-
Frame-shiftENST00000447079ENST00000583610CDK12chr17

37628016

+FBXL20chr17

37499494

-
Frame-shiftENST00000447079ENST00000394294CDK12chr17

37628016

+FBXL20chr17

37499494

-
Frame-shiftENST00000447079ENST00000264658CDK12chr17

37628016

+FBXL20chr17

37499494

-
Frame-shiftENST00000447079ENST00000577399CDK12chr17

37628016

+FBXL20chr17

37499494

-
intron-3CDSENST00000559545ENST00000583610CDK12chr17

37628016

+FBXL20chr17

37499494

-
intron-3CDSENST00000559545ENST00000394294CDK12chr17

37628016

+FBXL20chr17

37499494

-
intron-3CDSENST00000559545ENST00000264658CDK12chr17

37628016

+FBXL20chr17

37499494

-
intron-3CDSENST00000559545ENST00000577399CDK12chr17

37628016

+FBXL20chr17

37499494

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000430627CDK12chr1737628016+ENST00000583610FBXL20chr1737439108-323322421853058957
ENST00000430627CDK12chr1737628016+ENST00000394294FBXL20chr1737439108-393222421853058957
ENST00000430627CDK12chr1737628016+ENST00000264658FBXL20chr1737439108-393222421853058957
ENST00000430627CDK12chr1737628016+ENST00000577399FBXL20chr1737439108-305922421853058958
ENST00000447079CDK12chr1737628016+ENST00000583610FBXL20chr1737439108-29551964332780915
ENST00000447079CDK12chr1737628016+ENST00000394294FBXL20chr1737439108-36541964332780915
ENST00000447079CDK12chr1737628016+ENST00000264658FBXL20chr1737439108-36541964332780915
ENST00000447079CDK12chr1737628016+ENST00000577399FBXL20chr1737439108-27811964332780915

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000430627ENST00000583610CDK12chr1737628016+FBXL20chr1737439108-0.0030380230.996962
ENST00000430627ENST00000394294CDK12chr1737628016+FBXL20chr1737439108-0.0012989210.9987011
ENST00000430627ENST00000264658CDK12chr1737628016+FBXL20chr1737439108-0.0012989210.9987011
ENST00000430627ENST00000577399CDK12chr1737628016+FBXL20chr1737439108-0.0034473720.9965526
ENST00000447079ENST00000583610CDK12chr1737628016+FBXL20chr1737439108-0.0038871420.9961128
ENST00000447079ENST00000394294CDK12chr1737628016+FBXL20chr1737439108-0.0014879830.99851197
ENST00000447079ENST00000264658CDK12chr1737628016+FBXL20chr1737439108-0.0014879830.99851197
ENST00000447079ENST00000577399CDK12chr1737628016+FBXL20chr1737439108-0.0044611950.9955388

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Fusion Genomic Features for CDK12-FBXL20


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDK12-FBXL20


check button Go to

FGviewer for the breakpoints of chr17:37628016-chr17:37439108

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK12

Q9NYV4

FBXL20

Q96IG2

FUNCTION: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK12chr17:37628016chr17:37439108ENST00000430627+214407_413643.66666666666661482.0Compositional biasNote=Poly-Ala
HgeneCDK12chr17:37628016chr17:37439108ENST00000430627+214535_540643.66666666666661482.0Compositional biasNote=Poly-Pro
HgeneCDK12chr17:37628016chr17:37439108ENST00000447079+214407_413643.66666666666661491.0Compositional biasNote=Poly-Ala
HgeneCDK12chr17:37628016chr17:37439108ENST00000447079+214535_540643.66666666666661491.0Compositional biasNote=Poly-Pro
TgeneFBXL20chr17:37628016chr17:37439108ENST00000264658615179_204164.66666666666666437.0RepeatNote=LRR 5
TgeneFBXL20chr17:37628016chr17:37439108ENST00000264658615205_230164.66666666666666437.0RepeatNote=LRR 6
TgeneFBXL20chr17:37628016chr17:37439108ENST00000264658615231_256164.66666666666666437.0RepeatNote=LRR 7
TgeneFBXL20chr17:37628016chr17:37439108ENST00000264658615257_282164.66666666666666437.0RepeatNote=LRR 8
TgeneFBXL20chr17:37628016chr17:37439108ENST00000264658615283_308164.66666666666666437.0RepeatNote=LRR 9
TgeneFBXL20chr17:37628016chr17:37439108ENST00000264658615309_334164.66666666666666437.0RepeatNote=LRR 10
TgeneFBXL20chr17:37628016chr17:37439108ENST00000264658615335_363164.66666666666666437.0RepeatNote=LRR 11
TgeneFBXL20chr17:37628016chr17:37439108ENST00000264658615364_388164.66666666666666437.0RepeatNote=LRR 12
TgeneFBXL20chr17:37628016chr17:37439108ENST00000264658615389_414164.66666666666666437.0RepeatNote=LRR 13
TgeneFBXL20chr17:37628016chr17:37439108ENST00000394294514153_178132.66666666666666405.0RepeatNote=LRR 4
TgeneFBXL20chr17:37628016chr17:37439108ENST00000394294514179_204132.66666666666666405.0RepeatNote=LRR 5
TgeneFBXL20chr17:37628016chr17:37439108ENST00000394294514205_230132.66666666666666405.0RepeatNote=LRR 6
TgeneFBXL20chr17:37628016chr17:37439108ENST00000394294514231_256132.66666666666666405.0RepeatNote=LRR 7
TgeneFBXL20chr17:37628016chr17:37439108ENST00000394294514257_282132.66666666666666405.0RepeatNote=LRR 8
TgeneFBXL20chr17:37628016chr17:37439108ENST00000394294514283_308132.66666666666666405.0RepeatNote=LRR 9
TgeneFBXL20chr17:37628016chr17:37439108ENST00000394294514309_334132.66666666666666405.0RepeatNote=LRR 10
TgeneFBXL20chr17:37628016chr17:37439108ENST00000394294514335_363132.66666666666666405.0RepeatNote=LRR 11
TgeneFBXL20chr17:37628016chr17:37439108ENST00000394294514364_388132.66666666666666405.0RepeatNote=LRR 12
TgeneFBXL20chr17:37628016chr17:37439108ENST00000394294514389_414132.66666666666666405.0RepeatNote=LRR 13
TgeneFBXL20chr17:37628016chr17:37439108ENST00000583610616179_204164.66666666666666411.6666666666667RepeatNote=LRR 5
TgeneFBXL20chr17:37628016chr17:37439108ENST00000583610616205_230164.66666666666666411.6666666666667RepeatNote=LRR 6
TgeneFBXL20chr17:37628016chr17:37439108ENST00000583610616231_256164.66666666666666411.6666666666667RepeatNote=LRR 7
TgeneFBXL20chr17:37628016chr17:37439108ENST00000583610616257_282164.66666666666666411.6666666666667RepeatNote=LRR 8
TgeneFBXL20chr17:37628016chr17:37439108ENST00000583610616283_308164.66666666666666411.6666666666667RepeatNote=LRR 9
TgeneFBXL20chr17:37628016chr17:37439108ENST00000583610616309_334164.66666666666666411.6666666666667RepeatNote=LRR 10
TgeneFBXL20chr17:37628016chr17:37439108ENST00000583610616335_363164.66666666666666411.6666666666667RepeatNote=LRR 11
TgeneFBXL20chr17:37628016chr17:37439108ENST00000583610616364_388164.66666666666666411.6666666666667RepeatNote=LRR 12
TgeneFBXL20chr17:37628016chr17:37439108ENST00000583610616389_414164.66666666666666411.6666666666667RepeatNote=LRR 13

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK12chr17:37628016chr17:37439108ENST00000430627+2141266_1280643.66666666666661482.0Compositional biasNote=Poly-Pro
HgeneCDK12chr17:37628016chr17:37439108ENST00000447079+2141266_1280643.66666666666661491.0Compositional biasNote=Poly-Pro
HgeneCDK12chr17:37628016chr17:37439108ENST00000430627+214727_1020643.66666666666661482.0DomainProtein kinase
HgeneCDK12chr17:37628016chr17:37439108ENST00000447079+214727_1020643.66666666666661491.0DomainProtein kinase
HgeneCDK12chr17:37628016chr17:37439108ENST00000430627+214733_741643.66666666666661482.0Nucleotide bindingNote=ATP
HgeneCDK12chr17:37628016chr17:37439108ENST00000430627+214814_819643.66666666666661482.0Nucleotide bindingNote=ATP
HgeneCDK12chr17:37628016chr17:37439108ENST00000447079+214733_741643.66666666666661491.0Nucleotide bindingNote=ATP
HgeneCDK12chr17:37628016chr17:37439108ENST00000447079+214814_819643.66666666666661491.0Nucleotide bindingNote=ATP
TgeneFBXL20chr17:37628016chr17:37439108ENST0000026465861522_68164.66666666666666437.0DomainF-box
TgeneFBXL20chr17:37628016chr17:37439108ENST0000039429451422_68132.66666666666666405.0DomainF-box
TgeneFBXL20chr17:37628016chr17:37439108ENST0000058361061622_68164.66666666666666411.6666666666667DomainF-box
TgeneFBXL20chr17:37628016chr17:37439108ENST00000264658615101_126164.66666666666666437.0RepeatNote=LRR 2
TgeneFBXL20chr17:37628016chr17:37439108ENST00000264658615127_152164.66666666666666437.0RepeatNote=LRR 3
TgeneFBXL20chr17:37628016chr17:37439108ENST00000264658615153_178164.66666666666666437.0RepeatNote=LRR 4
TgeneFBXL20chr17:37628016chr17:37439108ENST0000026465861574_100164.66666666666666437.0RepeatNote=LRR 1
TgeneFBXL20chr17:37628016chr17:37439108ENST00000394294514101_126132.66666666666666405.0RepeatNote=LRR 2
TgeneFBXL20chr17:37628016chr17:37439108ENST00000394294514127_152132.66666666666666405.0RepeatNote=LRR 3
TgeneFBXL20chr17:37628016chr17:37439108ENST0000039429451474_100132.66666666666666405.0RepeatNote=LRR 1
TgeneFBXL20chr17:37628016chr17:37439108ENST00000583610616101_126164.66666666666666411.6666666666667RepeatNote=LRR 2
TgeneFBXL20chr17:37628016chr17:37439108ENST00000583610616127_152164.66666666666666411.6666666666667RepeatNote=LRR 3
TgeneFBXL20chr17:37628016chr17:37439108ENST00000583610616153_178164.66666666666666411.6666666666667RepeatNote=LRR 4
TgeneFBXL20chr17:37628016chr17:37439108ENST0000058361061674_100164.66666666666666411.6666666666667RepeatNote=LRR 1


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Fusion Gene Sequence for CDK12-FBXL20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000430627_ENST00000583610_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(transcript)=3233nt_BP=2242nt
CCCGGCGCCCGGGCCTGAGGACTGGCTCGGCGGAGGGAGAAGAGGAAACAGACTTGAGCAGCTCCCCGTTGTCTCGCAACTCCACTGCCG
AGGAACTCTCATTTCTTCCCTCGCTCCTTCACCCCCCACCTCATGTAGAAGGGTGCTGAGGCGTCGGGAGGGAGGAGGAGCCTGGGCTAC
CGTCCCTGCCCTCCCCACCCCCTTCCCGGGGCGCTTTGGTGGGCGTGGAGTTGGGGTTGGGGGGGTGGGTGGGGGTTGCTTTTTGGAGTG
CTGGGGAACTTTTTTCCCTTCTTCAGGTCAGGGGAAAGGGAATGCCCAATTCAGAGAGACATGGGGGCAAGAAGGACGGGAGTGGAGGAG
CTTCTGGAACTTTGCAGCCGTCATCGGGAGGCGGCAGCTCTAACAGCAGAGAGCGTCACCGCTTGGTATCGAAGCACAAGCGGCATAAGT
CCAAACACTCCAAAGACATGGGGTTGGTGACCCCCGAAGCAGCATCCCTGGGCACAGTTATCAAACCTTTGGTGGAGTATGATGATATCA
GCTCTGATTCCGACACCTTCTCCGATGACATGGCCTTCAAACTAGACCGAAGGGAGAACGACGAACGTCGTGGATCAGATCGGAGCGACC
GCCTGCACAAACATCGTCACCACCAGCACAGGCGTTCCCGGGACTTACTAAAAGCTAAACAGACCGAAAAAGAAAAAAGCCAAGAAGTCT
CCAGCAAGTCGGGATCGATGAAGGACCGGATATCGGGAAGTTCAAAGCGTTCGAATGAGGAGACTGATGACTATGGGAAGGCGCAGGTAG
CCAAAAGCAGCAGCAAGGAATCCAGGTCATCCAAGCTCCACAAGGAGAAGACCAGGAAAGAACGGGAGCTGAAGTCTGGGCACAAAGACC
GGAGTAAAAGTCATCGAAAAAGGGAAACACCCAAAAGTTACAAAACAGTGGACAGCCCAAAACGGAGATCCAGGAGCCCCCACAGGAAGT
GGTCTGACAGCTCCAAACAAGATGATAGCCCCTCGGGAGCTTCTTATGGCCAAGATTATGACCTTAGTCCCTCACGATCTCATACCTCGA
GCAATTATGACTCCTACAAGAAAAGTCCTGGAAGTACCTCGAGAAGGCAGTCGGTCAGTCCCCCTTACAAGGAGCCTTCGGCCTACCAGT
CCAGCACCCGGTCACCGAGCCCCTACAGTAGGCGACAGAGATCTGTCAGTCCCTATAGCAGGAGACGGTCGTCCAGCTACGAAAGAAGTG
GCTCTTACAGCGGGCGATCGCCCAGTCCCTATGGTCGAAGGCGGTCCAGCAGCCCTTTCCTGAGCAAGCGGTCTCTGAGTCGGAGTCCAC
TCCCCAGTAGGAAATCCATGAAGTCCAGAAGTAGAAGTCCTGCATATTCAAGACATTCATCTTCTCATAGTAAAAAGAAGAGATCCAGTT
CACGCAGTCGTCATTCCAGTATCTCACCTGTCAGGCTTCCACTTAATTCCAGTCTGGGAGCTGAACTCAGTAGGAAAAAGAAGGAAAGAG
CAGCTGCTGCTGCTGCAGCAAAGATGGATGGAAAGGAGTCCAAGGGTTCACCTGTATTTTTGCCTAGAAAAGAGAACAGTTCAGTAGAGG
CTAAGGATTCAGGTTTGGAGTCTAAAAAGTTACCCAGAAGTGTAAAATTGGAAAAATCTGCCCCAGATACTGAACTGGTGAATGTAACAC
ATCTAAACACAGAGGTAAAAAATTCTTCAGATACAGGGAAAGTAAAGTTGGATGAGAACTCCGAGAAGCATCTTGTTAAAGATTTGAAAG
CACAGGGAACAAGAGACTCTAAACCCATAGCACTGAAAGAGGAGATTGTTACTCCAAAGGAGACAGAAACATCAGAAAAGGAGACCCCTC
CACCTCTTCCCACAATTGCTTCTCCCCCACCCCCTCTACCAACTACTACCCCTCCACCTCAGACACCCCCTTTGCCACCTTTGCCTCCAA
TACCAGCTCTTCCACAGCAACCACCTCTGCCTCCTTCTCAGCCAGCATTTAGTCAGGTTCCTGCTTCCAGTACTTCAACTTTGCCCCCTT
CTACTCACTCAAAGACATCTGCTGTGTCCTCTCAGGCAAATTCTCAGCCCCCTGTACAGGTTTCTGTGAAGACTCAAGTATCTGTAACAG
CTGCTATTCCACACCTGAAAACTTCAACGTTGCCTCCTTTGCCCCTCCCACCCTTATTACCTGGAGATGATGACATGGATAGTGAGGGAT
GTCCACTGTTGGAGCAGTTGAACATTTCCTGGTGTGACCAAGTAACCAAGGATGGCATTCAAGCACTAGTGAGGGGCTGTGGGGGTCTCA
AGGCCTTATTCTTAAAAGGCTGCACGCAGCTAGAAGATGAAGCTCTCAAGTACATAGGTGCACACTGCCCTGAACTGGTGACTTTGAACT
TGCAGACTTGCTTGCAAATCACAGATGAAGGTCTCATTACTATATGCAGAGGGTGCCATAAGTTACAATCCCTTTGTGCCTCTGGCTGCT
CCAACATCACAGATGCCATCCTGAATGCTCTAGGTCAGAACTGCCCACGGCTTAGAATATTGGAAGTGGCAAGATGTTCTCAATTAACAG
ATGTGGGCTTTACCACTCTAGCCAGGAATTGCCATGAACTTGAAAAGATGGACCTGGAAGAGTGTGTTCAGATAACAGATAGCACATTAA
TCCAACTTTCTATACACTGTCCTCGACTTCAAGTATTGAGTCTGTCTCACTGTGAGCTGATCACAGATGATGGAATTCGTCACCTGGGGA
ATGGGGCCTGCGCCCATGACCAGCTGGAGGTGATTGAGCTGGACAACTGCCCACTAATCACAGATGCATCCCTGGAGCACTTGAAGAGCT
GTCATAGCCTTGAGCGGATAGAACTCTATGACTGCCAGCAAATCACACGGGCTGGAATCAAGAGACTCAGGACCCATTTACCCAATATTA
AAGTCCACGCCTACTTCGCACCTGTCACTCCACCCCCATCAGTAGGGGGCAGCAGACAGCGCTTCTGCAGATGCTGCATCATCCTATGAC
AATGGAGAGATGGGGTCTCGCTATCTTGCCCAGCCTGGACTCAAACTCCTGGGCTCAAGCCTTCCTCCCACCTCAGCCTCCCAAGTAGCT

>In-frame_ENST00000430627_ENST00000583610_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(amino acids)=957AA_start in transcript=185_stop in transcript=3058
MPSPPPSRGALVGVELGLGGWVGVAFWSAGELFSLLQVRGKGMPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSK
HSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSS
KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS
DSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGS
YSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAA
AAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQ
GTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPST
HSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKA
LFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDV
GFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCH

--------------------------------------------------------------
>In-frame_ENST00000430627_ENST00000394294_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(transcript)=3932nt_BP=2242nt
CCCGGCGCCCGGGCCTGAGGACTGGCTCGGCGGAGGGAGAAGAGGAAACAGACTTGAGCAGCTCCCCGTTGTCTCGCAACTCCACTGCCG
AGGAACTCTCATTTCTTCCCTCGCTCCTTCACCCCCCACCTCATGTAGAAGGGTGCTGAGGCGTCGGGAGGGAGGAGGAGCCTGGGCTAC
CGTCCCTGCCCTCCCCACCCCCTTCCCGGGGCGCTTTGGTGGGCGTGGAGTTGGGGTTGGGGGGGTGGGTGGGGGTTGCTTTTTGGAGTG
CTGGGGAACTTTTTTCCCTTCTTCAGGTCAGGGGAAAGGGAATGCCCAATTCAGAGAGACATGGGGGCAAGAAGGACGGGAGTGGAGGAG
CTTCTGGAACTTTGCAGCCGTCATCGGGAGGCGGCAGCTCTAACAGCAGAGAGCGTCACCGCTTGGTATCGAAGCACAAGCGGCATAAGT
CCAAACACTCCAAAGACATGGGGTTGGTGACCCCCGAAGCAGCATCCCTGGGCACAGTTATCAAACCTTTGGTGGAGTATGATGATATCA
GCTCTGATTCCGACACCTTCTCCGATGACATGGCCTTCAAACTAGACCGAAGGGAGAACGACGAACGTCGTGGATCAGATCGGAGCGACC
GCCTGCACAAACATCGTCACCACCAGCACAGGCGTTCCCGGGACTTACTAAAAGCTAAACAGACCGAAAAAGAAAAAAGCCAAGAAGTCT
CCAGCAAGTCGGGATCGATGAAGGACCGGATATCGGGAAGTTCAAAGCGTTCGAATGAGGAGACTGATGACTATGGGAAGGCGCAGGTAG
CCAAAAGCAGCAGCAAGGAATCCAGGTCATCCAAGCTCCACAAGGAGAAGACCAGGAAAGAACGGGAGCTGAAGTCTGGGCACAAAGACC
GGAGTAAAAGTCATCGAAAAAGGGAAACACCCAAAAGTTACAAAACAGTGGACAGCCCAAAACGGAGATCCAGGAGCCCCCACAGGAAGT
GGTCTGACAGCTCCAAACAAGATGATAGCCCCTCGGGAGCTTCTTATGGCCAAGATTATGACCTTAGTCCCTCACGATCTCATACCTCGA
GCAATTATGACTCCTACAAGAAAAGTCCTGGAAGTACCTCGAGAAGGCAGTCGGTCAGTCCCCCTTACAAGGAGCCTTCGGCCTACCAGT
CCAGCACCCGGTCACCGAGCCCCTACAGTAGGCGACAGAGATCTGTCAGTCCCTATAGCAGGAGACGGTCGTCCAGCTACGAAAGAAGTG
GCTCTTACAGCGGGCGATCGCCCAGTCCCTATGGTCGAAGGCGGTCCAGCAGCCCTTTCCTGAGCAAGCGGTCTCTGAGTCGGAGTCCAC
TCCCCAGTAGGAAATCCATGAAGTCCAGAAGTAGAAGTCCTGCATATTCAAGACATTCATCTTCTCATAGTAAAAAGAAGAGATCCAGTT
CACGCAGTCGTCATTCCAGTATCTCACCTGTCAGGCTTCCACTTAATTCCAGTCTGGGAGCTGAACTCAGTAGGAAAAAGAAGGAAAGAG
CAGCTGCTGCTGCTGCAGCAAAGATGGATGGAAAGGAGTCCAAGGGTTCACCTGTATTTTTGCCTAGAAAAGAGAACAGTTCAGTAGAGG
CTAAGGATTCAGGTTTGGAGTCTAAAAAGTTACCCAGAAGTGTAAAATTGGAAAAATCTGCCCCAGATACTGAACTGGTGAATGTAACAC
ATCTAAACACAGAGGTAAAAAATTCTTCAGATACAGGGAAAGTAAAGTTGGATGAGAACTCCGAGAAGCATCTTGTTAAAGATTTGAAAG
CACAGGGAACAAGAGACTCTAAACCCATAGCACTGAAAGAGGAGATTGTTACTCCAAAGGAGACAGAAACATCAGAAAAGGAGACCCCTC
CACCTCTTCCCACAATTGCTTCTCCCCCACCCCCTCTACCAACTACTACCCCTCCACCTCAGACACCCCCTTTGCCACCTTTGCCTCCAA
TACCAGCTCTTCCACAGCAACCACCTCTGCCTCCTTCTCAGCCAGCATTTAGTCAGGTTCCTGCTTCCAGTACTTCAACTTTGCCCCCTT
CTACTCACTCAAAGACATCTGCTGTGTCCTCTCAGGCAAATTCTCAGCCCCCTGTACAGGTTTCTGTGAAGACTCAAGTATCTGTAACAG
CTGCTATTCCACACCTGAAAACTTCAACGTTGCCTCCTTTGCCCCTCCCACCCTTATTACCTGGAGATGATGACATGGATAGTGAGGGAT
GTCCACTGTTGGAGCAGTTGAACATTTCCTGGTGTGACCAAGTAACCAAGGATGGCATTCAAGCACTAGTGAGGGGCTGTGGGGGTCTCA
AGGCCTTATTCTTAAAAGGCTGCACGCAGCTAGAAGATGAAGCTCTCAAGTACATAGGTGCACACTGCCCTGAACTGGTGACTTTGAACT
TGCAGACTTGCTTGCAAATCACAGATGAAGGTCTCATTACTATATGCAGAGGGTGCCATAAGTTACAATCCCTTTGTGCCTCTGGCTGCT
CCAACATCACAGATGCCATCCTGAATGCTCTAGGTCAGAACTGCCCACGGCTTAGAATATTGGAAGTGGCAAGATGTTCTCAATTAACAG
ATGTGGGCTTTACCACTCTAGCCAGGAATTGCCATGAACTTGAAAAGATGGACCTGGAAGAGTGTGTTCAGATAACAGATAGCACATTAA
TCCAACTTTCTATACACTGTCCTCGACTTCAAGTATTGAGTCTGTCTCACTGTGAGCTGATCACAGATGATGGAATTCGTCACCTGGGGA
ATGGGGCCTGCGCCCATGACCAGCTGGAGGTGATTGAGCTGGACAACTGCCCACTAATCACAGATGCATCCCTGGAGCACTTGAAGAGCT
GTCATAGCCTTGAGCGGATAGAACTCTATGACTGCCAGCAAATCACACGGGCTGGAATCAAGAGACTCAGGACCCATTTACCCAATATTA
AAGTCCACGCCTACTTCGCACCTGTCACTCCACCCCCATCAGTAGGGGGCAGCAGACAGCGCTTCTGCAGATGCTGCATCATCCTATGAC
AATGGAGGTGGTCAACCTTGGCGAACTGAGTATTTAATGACACTTCTAGAGCTACCGTGGAGTCTCTCCAGTGGAAGCAACCCCAGTGTT
CTGAGCAAGGGTTACAAAGTGAGGGAGGGCAGTGTCCAGATCCCCAGAGCCACACATACATACACATACACACCCTTACCCCCATCCACT
CTAGCTTTGTGACCATGGGACTGAAGTTTGTGATGGCTTTTTTATCAAGTAGATTGGTAAAATTTAACCATTCCTGTTGAGGTGCCCATA
AGAAAATCATAGGCCAAGATAGGGAGGGGCATTCCAGCAAACCCCGTGTTAATGCTACTGTGGTTTTTAAATTTTTGTCTAGGGGTTTCT
TTGGGGATTTTAGAACAGCATCTGCTGTCCTCCGGGGTCAAGAAAAGCATGGAAAGACAATATATGATGTACCCAGGGACCAGAAAGAAA
ATTTCTTTGCATCTTAGAAATGGTAGACATTCATTGTGACTAAAGAGCTTCTATGCTTCCTTGTTTCCATGCCAACATGCTGAGCATGCT
CACAAAGAAGGCTCGTCCATTCCTCCTGTGTTTTAGTATTTGGCCCAGAGGTTTCCTAAATGGTTGCCTTGAAATCACTGTGGTCCAAAT
GTAATTCTTACACACTCAAATTATCACTGTCTGTAGCACACTTGTGCACCTGTCTTACATTCTCTGTTGCTCCCCCCCACACTCTTGCTC
AGTCTGTCACCTGTTCAGTCTGCTTACTCACTCAATTGTTACCCTTTTGCTGTTGTCGTGTTTACAGTTTGCATTTTGAATGATTAGTTG

>In-frame_ENST00000430627_ENST00000394294_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(amino acids)=957AA_start in transcript=185_stop in transcript=3058
MPSPPPSRGALVGVELGLGGWVGVAFWSAGELFSLLQVRGKGMPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSK
HSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSS
KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS
DSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGS
YSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAA
AAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQ
GTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPST
HSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKA
LFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDV
GFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCH

--------------------------------------------------------------
>In-frame_ENST00000430627_ENST00000264658_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(transcript)=3932nt_BP=2242nt
CCCGGCGCCCGGGCCTGAGGACTGGCTCGGCGGAGGGAGAAGAGGAAACAGACTTGAGCAGCTCCCCGTTGTCTCGCAACTCCACTGCCG
AGGAACTCTCATTTCTTCCCTCGCTCCTTCACCCCCCACCTCATGTAGAAGGGTGCTGAGGCGTCGGGAGGGAGGAGGAGCCTGGGCTAC
CGTCCCTGCCCTCCCCACCCCCTTCCCGGGGCGCTTTGGTGGGCGTGGAGTTGGGGTTGGGGGGGTGGGTGGGGGTTGCTTTTTGGAGTG
CTGGGGAACTTTTTTCCCTTCTTCAGGTCAGGGGAAAGGGAATGCCCAATTCAGAGAGACATGGGGGCAAGAAGGACGGGAGTGGAGGAG
CTTCTGGAACTTTGCAGCCGTCATCGGGAGGCGGCAGCTCTAACAGCAGAGAGCGTCACCGCTTGGTATCGAAGCACAAGCGGCATAAGT
CCAAACACTCCAAAGACATGGGGTTGGTGACCCCCGAAGCAGCATCCCTGGGCACAGTTATCAAACCTTTGGTGGAGTATGATGATATCA
GCTCTGATTCCGACACCTTCTCCGATGACATGGCCTTCAAACTAGACCGAAGGGAGAACGACGAACGTCGTGGATCAGATCGGAGCGACC
GCCTGCACAAACATCGTCACCACCAGCACAGGCGTTCCCGGGACTTACTAAAAGCTAAACAGACCGAAAAAGAAAAAAGCCAAGAAGTCT
CCAGCAAGTCGGGATCGATGAAGGACCGGATATCGGGAAGTTCAAAGCGTTCGAATGAGGAGACTGATGACTATGGGAAGGCGCAGGTAG
CCAAAAGCAGCAGCAAGGAATCCAGGTCATCCAAGCTCCACAAGGAGAAGACCAGGAAAGAACGGGAGCTGAAGTCTGGGCACAAAGACC
GGAGTAAAAGTCATCGAAAAAGGGAAACACCCAAAAGTTACAAAACAGTGGACAGCCCAAAACGGAGATCCAGGAGCCCCCACAGGAAGT
GGTCTGACAGCTCCAAACAAGATGATAGCCCCTCGGGAGCTTCTTATGGCCAAGATTATGACCTTAGTCCCTCACGATCTCATACCTCGA
GCAATTATGACTCCTACAAGAAAAGTCCTGGAAGTACCTCGAGAAGGCAGTCGGTCAGTCCCCCTTACAAGGAGCCTTCGGCCTACCAGT
CCAGCACCCGGTCACCGAGCCCCTACAGTAGGCGACAGAGATCTGTCAGTCCCTATAGCAGGAGACGGTCGTCCAGCTACGAAAGAAGTG
GCTCTTACAGCGGGCGATCGCCCAGTCCCTATGGTCGAAGGCGGTCCAGCAGCCCTTTCCTGAGCAAGCGGTCTCTGAGTCGGAGTCCAC
TCCCCAGTAGGAAATCCATGAAGTCCAGAAGTAGAAGTCCTGCATATTCAAGACATTCATCTTCTCATAGTAAAAAGAAGAGATCCAGTT
CACGCAGTCGTCATTCCAGTATCTCACCTGTCAGGCTTCCACTTAATTCCAGTCTGGGAGCTGAACTCAGTAGGAAAAAGAAGGAAAGAG
CAGCTGCTGCTGCTGCAGCAAAGATGGATGGAAAGGAGTCCAAGGGTTCACCTGTATTTTTGCCTAGAAAAGAGAACAGTTCAGTAGAGG
CTAAGGATTCAGGTTTGGAGTCTAAAAAGTTACCCAGAAGTGTAAAATTGGAAAAATCTGCCCCAGATACTGAACTGGTGAATGTAACAC
ATCTAAACACAGAGGTAAAAAATTCTTCAGATACAGGGAAAGTAAAGTTGGATGAGAACTCCGAGAAGCATCTTGTTAAAGATTTGAAAG
CACAGGGAACAAGAGACTCTAAACCCATAGCACTGAAAGAGGAGATTGTTACTCCAAAGGAGACAGAAACATCAGAAAAGGAGACCCCTC
CACCTCTTCCCACAATTGCTTCTCCCCCACCCCCTCTACCAACTACTACCCCTCCACCTCAGACACCCCCTTTGCCACCTTTGCCTCCAA
TACCAGCTCTTCCACAGCAACCACCTCTGCCTCCTTCTCAGCCAGCATTTAGTCAGGTTCCTGCTTCCAGTACTTCAACTTTGCCCCCTT
CTACTCACTCAAAGACATCTGCTGTGTCCTCTCAGGCAAATTCTCAGCCCCCTGTACAGGTTTCTGTGAAGACTCAAGTATCTGTAACAG
CTGCTATTCCACACCTGAAAACTTCAACGTTGCCTCCTTTGCCCCTCCCACCCTTATTACCTGGAGATGATGACATGGATAGTGAGGGAT
GTCCACTGTTGGAGCAGTTGAACATTTCCTGGTGTGACCAAGTAACCAAGGATGGCATTCAAGCACTAGTGAGGGGCTGTGGGGGTCTCA
AGGCCTTATTCTTAAAAGGCTGCACGCAGCTAGAAGATGAAGCTCTCAAGTACATAGGTGCACACTGCCCTGAACTGGTGACTTTGAACT
TGCAGACTTGCTTGCAAATCACAGATGAAGGTCTCATTACTATATGCAGAGGGTGCCATAAGTTACAATCCCTTTGTGCCTCTGGCTGCT
CCAACATCACAGATGCCATCCTGAATGCTCTAGGTCAGAACTGCCCACGGCTTAGAATATTGGAAGTGGCAAGATGTTCTCAATTAACAG
ATGTGGGCTTTACCACTCTAGCCAGGAATTGCCATGAACTTGAAAAGATGGACCTGGAAGAGTGTGTTCAGATAACAGATAGCACATTAA
TCCAACTTTCTATACACTGTCCTCGACTTCAAGTATTGAGTCTGTCTCACTGTGAGCTGATCACAGATGATGGAATTCGTCACCTGGGGA
ATGGGGCCTGCGCCCATGACCAGCTGGAGGTGATTGAGCTGGACAACTGCCCACTAATCACAGATGCATCCCTGGAGCACTTGAAGAGCT
GTCATAGCCTTGAGCGGATAGAACTCTATGACTGCCAGCAAATCACACGGGCTGGAATCAAGAGACTCAGGACCCATTTACCCAATATTA
AAGTCCACGCCTACTTCGCACCTGTCACTCCACCCCCATCAGTAGGGGGCAGCAGACAGCGCTTCTGCAGATGCTGCATCATCCTATGAC
AATGGAGGTGGTCAACCTTGGCGAACTGAGTATTTAATGACACTTCTAGAGCTACCGTGGAGTCTCTCCAGTGGAAGCAACCCCAGTGTT
CTGAGCAAGGGTTACAAAGTGAGGGAGGGCAGTGTCCAGATCCCCAGAGCCACACATACATACACATACACACCCTTACCCCCATCCACT
CTAGCTTTGTGACCATGGGACTGAAGTTTGTGATGGCTTTTTTATCAAGTAGATTGGTAAAATTTAACCATTCCTGTTGAGGTGCCCATA
AGAAAATCATAGGCCAAGATAGGGAGGGGCATTCCAGCAAACCCCGTGTTAATGCTACTGTGGTTTTTAAATTTTTGTCTAGGGGTTTCT
TTGGGGATTTTAGAACAGCATCTGCTGTCCTCCGGGGTCAAGAAAAGCATGGAAAGACAATATATGATGTACCCAGGGACCAGAAAGAAA
ATTTCTTTGCATCTTAGAAATGGTAGACATTCATTGTGACTAAAGAGCTTCTATGCTTCCTTGTTTCCATGCCAACATGCTGAGCATGCT
CACAAAGAAGGCTCGTCCATTCCTCCTGTGTTTTAGTATTTGGCCCAGAGGTTTCCTAAATGGTTGCCTTGAAATCACTGTGGTCCAAAT
GTAATTCTTACACACTCAAATTATCACTGTCTGTAGCACACTTGTGCACCTGTCTTACATTCTCTGTTGCTCCCCCCCACACTCTTGCTC
AGTCTGTCACCTGTTCAGTCTGCTTACTCACTCAATTGTTACCCTTTTGCTGTTGTCGTGTTTACAGTTTGCATTTTGAATGATTAGTTG

>In-frame_ENST00000430627_ENST00000264658_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(amino acids)=957AA_start in transcript=185_stop in transcript=3058
MPSPPPSRGALVGVELGLGGWVGVAFWSAGELFSLLQVRGKGMPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSK
HSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSS
KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS
DSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGS
YSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAA
AAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQ
GTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPST
HSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKA
LFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDV
GFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCH

--------------------------------------------------------------
>In-frame_ENST00000430627_ENST00000577399_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(transcript)=3059nt_BP=2242nt
CCCGGCGCCCGGGCCTGAGGACTGGCTCGGCGGAGGGAGAAGAGGAAACAGACTTGAGCAGCTCCCCGTTGTCTCGCAACTCCACTGCCG
AGGAACTCTCATTTCTTCCCTCGCTCCTTCACCCCCCACCTCATGTAGAAGGGTGCTGAGGCGTCGGGAGGGAGGAGGAGCCTGGGCTAC
CGTCCCTGCCCTCCCCACCCCCTTCCCGGGGCGCTTTGGTGGGCGTGGAGTTGGGGTTGGGGGGGTGGGTGGGGGTTGCTTTTTGGAGTG
CTGGGGAACTTTTTTCCCTTCTTCAGGTCAGGGGAAAGGGAATGCCCAATTCAGAGAGACATGGGGGCAAGAAGGACGGGAGTGGAGGAG
CTTCTGGAACTTTGCAGCCGTCATCGGGAGGCGGCAGCTCTAACAGCAGAGAGCGTCACCGCTTGGTATCGAAGCACAAGCGGCATAAGT
CCAAACACTCCAAAGACATGGGGTTGGTGACCCCCGAAGCAGCATCCCTGGGCACAGTTATCAAACCTTTGGTGGAGTATGATGATATCA
GCTCTGATTCCGACACCTTCTCCGATGACATGGCCTTCAAACTAGACCGAAGGGAGAACGACGAACGTCGTGGATCAGATCGGAGCGACC
GCCTGCACAAACATCGTCACCACCAGCACAGGCGTTCCCGGGACTTACTAAAAGCTAAACAGACCGAAAAAGAAAAAAGCCAAGAAGTCT
CCAGCAAGTCGGGATCGATGAAGGACCGGATATCGGGAAGTTCAAAGCGTTCGAATGAGGAGACTGATGACTATGGGAAGGCGCAGGTAG
CCAAAAGCAGCAGCAAGGAATCCAGGTCATCCAAGCTCCACAAGGAGAAGACCAGGAAAGAACGGGAGCTGAAGTCTGGGCACAAAGACC
GGAGTAAAAGTCATCGAAAAAGGGAAACACCCAAAAGTTACAAAACAGTGGACAGCCCAAAACGGAGATCCAGGAGCCCCCACAGGAAGT
GGTCTGACAGCTCCAAACAAGATGATAGCCCCTCGGGAGCTTCTTATGGCCAAGATTATGACCTTAGTCCCTCACGATCTCATACCTCGA
GCAATTATGACTCCTACAAGAAAAGTCCTGGAAGTACCTCGAGAAGGCAGTCGGTCAGTCCCCCTTACAAGGAGCCTTCGGCCTACCAGT
CCAGCACCCGGTCACCGAGCCCCTACAGTAGGCGACAGAGATCTGTCAGTCCCTATAGCAGGAGACGGTCGTCCAGCTACGAAAGAAGTG
GCTCTTACAGCGGGCGATCGCCCAGTCCCTATGGTCGAAGGCGGTCCAGCAGCCCTTTCCTGAGCAAGCGGTCTCTGAGTCGGAGTCCAC
TCCCCAGTAGGAAATCCATGAAGTCCAGAAGTAGAAGTCCTGCATATTCAAGACATTCATCTTCTCATAGTAAAAAGAAGAGATCCAGTT
CACGCAGTCGTCATTCCAGTATCTCACCTGTCAGGCTTCCACTTAATTCCAGTCTGGGAGCTGAACTCAGTAGGAAAAAGAAGGAAAGAG
CAGCTGCTGCTGCTGCAGCAAAGATGGATGGAAAGGAGTCCAAGGGTTCACCTGTATTTTTGCCTAGAAAAGAGAACAGTTCAGTAGAGG
CTAAGGATTCAGGTTTGGAGTCTAAAAAGTTACCCAGAAGTGTAAAATTGGAAAAATCTGCCCCAGATACTGAACTGGTGAATGTAACAC
ATCTAAACACAGAGGTAAAAAATTCTTCAGATACAGGGAAAGTAAAGTTGGATGAGAACTCCGAGAAGCATCTTGTTAAAGATTTGAAAG
CACAGGGAACAAGAGACTCTAAACCCATAGCACTGAAAGAGGAGATTGTTACTCCAAAGGAGACAGAAACATCAGAAAAGGAGACCCCTC
CACCTCTTCCCACAATTGCTTCTCCCCCACCCCCTCTACCAACTACTACCCCTCCACCTCAGACACCCCCTTTGCCACCTTTGCCTCCAA
TACCAGCTCTTCCACAGCAACCACCTCTGCCTCCTTCTCAGCCAGCATTTAGTCAGGTTCCTGCTTCCAGTACTTCAACTTTGCCCCCTT
CTACTCACTCAAAGACATCTGCTGTGTCCTCTCAGGCAAATTCTCAGCCCCCTGTACAGGTTTCTGTGAAGACTCAAGTATCTGTAACAG
CTGCTATTCCACACCTGAAAACTTCAACGTTGCCTCCTTTGCCCCTCCCACCCTTATTACCTGGAGATGATGACATGGATAGTGAGGGAT
GTCCACTGTTGGAGCAGTTGAACATTTCCTGGTGTGACCAAGTAACCAAGGATGGCATTCAAGCACTAGTGAGGGGCTGTGGGGGTCTCA
AGGCCTTATTCTTAAAAGGCTGCACGCAGCTAGAAGATGAAGCTCTCAAGTACATAGGTGCACACTGCCCTGAACTGGTGACTTTGAACT
TGCAGACTTGCTTGCAAATCACAGATGAAGGTCTCATTACTATATGCAGAGGGTGCCATAAGTTACAATCCCTTTGTGCCTCTGGCTGCT
CCAACATCACAGATGCCATCCTGAATGCTCTAGGTCAGAACTGCCCACGGCTTAGAATATTGGAAGTGGCAAGATGTTCTCAATTAACAG
ATGTGGGCTTTACCACTCTAGCCAGGAATTGCCATGAACTTGAAAAGATGGACCTGGAAGAGTGTGTTCAGATAACAGATAGCACATTAA
TCCAACTTTCTATACACTGTCCTCGACTTCAAGTATTGAGTCTGTCTCACTGTGAGCTGATCACAGATGATGGAATTCGTCACCTGGGGA
ATGGGGCCTGCGCCCATGACCAGCTGGAGGTGATTGAGCTGGACAACTGCCCACTAATCACAGATGCATCCCTGGAGCACTTGAAGAGCT
GTCATAGCCTTGAGCGGATAGAACTCTATGACTGCCAGCAAATCACACGGGCTGGAATCAAGAGACTCAGGACCCATTTACCCAATATTA

>In-frame_ENST00000430627_ENST00000577399_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(amino acids)=958AA_start in transcript=185_stop in transcript=3058
MPSPPPSRGALVGVELGLGGWVGVAFWSAGELFSLLQVRGKGMPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSK
HSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSS
KSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWS
DSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGS
YSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAA
AAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQ
GTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPST
HSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKA
LFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDV
GFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCH

--------------------------------------------------------------
>In-frame_ENST00000447079_ENST00000583610_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(transcript)=2955nt_BP=1964nt
CTTTTTTCCCTTCTTCAGGTCAGGGGAAAGGGAATGCCCAATTCAGAGAGACATGGGGGCAAGAAGGACGGGAGTGGAGGAGCTTCTGGA
ACTTTGCAGCCGTCATCGGGAGGCGGCAGCTCTAACAGCAGAGAGCGTCACCGCTTGGTATCGAAGCACAAGCGGCATAAGTCCAAACAC
TCCAAAGACATGGGGTTGGTGACCCCCGAAGCAGCATCCCTGGGCACAGTTATCAAACCTTTGGTGGAGTATGATGATATCAGCTCTGAT
TCCGACACCTTCTCCGATGACATGGCCTTCAAACTAGACCGAAGGGAGAACGACGAACGTCGTGGATCAGATCGGAGCGACCGCCTGCAC
AAACATCGTCACCACCAGCACAGGCGTTCCCGGGACTTACTAAAAGCTAAACAGACCGAAAAAGAAAAAAGCCAAGAAGTCTCCAGCAAG
TCGGGATCGATGAAGGACCGGATATCGGGAAGTTCAAAGCGTTCGAATGAGGAGACTGATGACTATGGGAAGGCGCAGGTAGCCAAAAGC
AGCAGCAAGGAATCCAGGTCATCCAAGCTCCACAAGGAGAAGACCAGGAAAGAACGGGAGCTGAAGTCTGGGCACAAAGACCGGAGTAAA
AGTCATCGAAAAAGGGAAACACCCAAAAGTTACAAAACAGTGGACAGCCCAAAACGGAGATCCAGGAGCCCCCACAGGAAGTGGTCTGAC
AGCTCCAAACAAGATGATAGCCCCTCGGGAGCTTCTTATGGCCAAGATTATGACCTTAGTCCCTCACGATCTCATACCTCGAGCAATTAT
GACTCCTACAAGAAAAGTCCTGGAAGTACCTCGAGAAGGCAGTCGGTCAGTCCCCCTTACAAGGAGCCTTCGGCCTACCAGTCCAGCACC
CGGTCACCGAGCCCCTACAGTAGGCGACAGAGATCTGTCAGTCCCTATAGCAGGAGACGGTCGTCCAGCTACGAAAGAAGTGGCTCTTAC
AGCGGGCGATCGCCCAGTCCCTATGGTCGAAGGCGGTCCAGCAGCCCTTTCCTGAGCAAGCGGTCTCTGAGTCGGAGTCCACTCCCCAGT
AGGAAATCCATGAAGTCCAGAAGTAGAAGTCCTGCATATTCAAGACATTCATCTTCTCATAGTAAAAAGAAGAGATCCAGTTCACGCAGT
CGTCATTCCAGTATCTCACCTGTCAGGCTTCCACTTAATTCCAGTCTGGGAGCTGAACTCAGTAGGAAAAAGAAGGAAAGAGCAGCTGCT
GCTGCTGCAGCAAAGATGGATGGAAAGGAGTCCAAGGGTTCACCTGTATTTTTGCCTAGAAAAGAGAACAGTTCAGTAGAGGCTAAGGAT
TCAGGTTTGGAGTCTAAAAAGTTACCCAGAAGTGTAAAATTGGAAAAATCTGCCCCAGATACTGAACTGGTGAATGTAACACATCTAAAC
ACAGAGGTAAAAAATTCTTCAGATACAGGGAAAGTAAAGTTGGATGAGAACTCCGAGAAGCATCTTGTTAAAGATTTGAAAGCACAGGGA
ACAAGAGACTCTAAACCCATAGCACTGAAAGAGGAGATTGTTACTCCAAAGGAGACAGAAACATCAGAAAAGGAGACCCCTCCACCTCTT
CCCACAATTGCTTCTCCCCCACCCCCTCTACCAACTACTACCCCTCCACCTCAGACACCCCCTTTGCCACCTTTGCCTCCAATACCAGCT
CTTCCACAGCAACCACCTCTGCCTCCTTCTCAGCCAGCATTTAGTCAGGTTCCTGCTTCCAGTACTTCAACTTTGCCCCCTTCTACTCAC
TCAAAGACATCTGCTGTGTCCTCTCAGGCAAATTCTCAGCCCCCTGTACAGGTTTCTGTGAAGACTCAAGTATCTGTAACAGCTGCTATT
CCACACCTGAAAACTTCAACGTTGCCTCCTTTGCCCCTCCCACCCTTATTACCTGGAGATGATGACATGGATAGTGAGGGATGTCCACTG
TTGGAGCAGTTGAACATTTCCTGGTGTGACCAAGTAACCAAGGATGGCATTCAAGCACTAGTGAGGGGCTGTGGGGGTCTCAAGGCCTTA
TTCTTAAAAGGCTGCACGCAGCTAGAAGATGAAGCTCTCAAGTACATAGGTGCACACTGCCCTGAACTGGTGACTTTGAACTTGCAGACT
TGCTTGCAAATCACAGATGAAGGTCTCATTACTATATGCAGAGGGTGCCATAAGTTACAATCCCTTTGTGCCTCTGGCTGCTCCAACATC
ACAGATGCCATCCTGAATGCTCTAGGTCAGAACTGCCCACGGCTTAGAATATTGGAAGTGGCAAGATGTTCTCAATTAACAGATGTGGGC
TTTACCACTCTAGCCAGGAATTGCCATGAACTTGAAAAGATGGACCTGGAAGAGTGTGTTCAGATAACAGATAGCACATTAATCCAACTT
TCTATACACTGTCCTCGACTTCAAGTATTGAGTCTGTCTCACTGTGAGCTGATCACAGATGATGGAATTCGTCACCTGGGGAATGGGGCC
TGCGCCCATGACCAGCTGGAGGTGATTGAGCTGGACAACTGCCCACTAATCACAGATGCATCCCTGGAGCACTTGAAGAGCTGTCATAGC
CTTGAGCGGATAGAACTCTATGACTGCCAGCAAATCACACGGGCTGGAATCAAGAGACTCAGGACCCATTTACCCAATATTAAAGTCCAC
GCCTACTTCGCACCTGTCACTCCACCCCCATCAGTAGGGGGCAGCAGACAGCGCTTCTGCAGATGCTGCATCATCCTATGACAATGGAGA
GATGGGGTCTCGCTATCTTGCCCAGCCTGGACTCAAACTCCTGGGCTCAAGCCTTCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTAC

>In-frame_ENST00000447079_ENST00000583610_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(amino acids)=915AA_start in transcript=33_stop in transcript=2780
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK
LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS
RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL
PLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLIT
ICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLS
LSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPS

--------------------------------------------------------------
>In-frame_ENST00000447079_ENST00000394294_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(transcript)=3654nt_BP=1964nt
CTTTTTTCCCTTCTTCAGGTCAGGGGAAAGGGAATGCCCAATTCAGAGAGACATGGGGGCAAGAAGGACGGGAGTGGAGGAGCTTCTGGA
ACTTTGCAGCCGTCATCGGGAGGCGGCAGCTCTAACAGCAGAGAGCGTCACCGCTTGGTATCGAAGCACAAGCGGCATAAGTCCAAACAC
TCCAAAGACATGGGGTTGGTGACCCCCGAAGCAGCATCCCTGGGCACAGTTATCAAACCTTTGGTGGAGTATGATGATATCAGCTCTGAT
TCCGACACCTTCTCCGATGACATGGCCTTCAAACTAGACCGAAGGGAGAACGACGAACGTCGTGGATCAGATCGGAGCGACCGCCTGCAC
AAACATCGTCACCACCAGCACAGGCGTTCCCGGGACTTACTAAAAGCTAAACAGACCGAAAAAGAAAAAAGCCAAGAAGTCTCCAGCAAG
TCGGGATCGATGAAGGACCGGATATCGGGAAGTTCAAAGCGTTCGAATGAGGAGACTGATGACTATGGGAAGGCGCAGGTAGCCAAAAGC
AGCAGCAAGGAATCCAGGTCATCCAAGCTCCACAAGGAGAAGACCAGGAAAGAACGGGAGCTGAAGTCTGGGCACAAAGACCGGAGTAAA
AGTCATCGAAAAAGGGAAACACCCAAAAGTTACAAAACAGTGGACAGCCCAAAACGGAGATCCAGGAGCCCCCACAGGAAGTGGTCTGAC
AGCTCCAAACAAGATGATAGCCCCTCGGGAGCTTCTTATGGCCAAGATTATGACCTTAGTCCCTCACGATCTCATACCTCGAGCAATTAT
GACTCCTACAAGAAAAGTCCTGGAAGTACCTCGAGAAGGCAGTCGGTCAGTCCCCCTTACAAGGAGCCTTCGGCCTACCAGTCCAGCACC
CGGTCACCGAGCCCCTACAGTAGGCGACAGAGATCTGTCAGTCCCTATAGCAGGAGACGGTCGTCCAGCTACGAAAGAAGTGGCTCTTAC
AGCGGGCGATCGCCCAGTCCCTATGGTCGAAGGCGGTCCAGCAGCCCTTTCCTGAGCAAGCGGTCTCTGAGTCGGAGTCCACTCCCCAGT
AGGAAATCCATGAAGTCCAGAAGTAGAAGTCCTGCATATTCAAGACATTCATCTTCTCATAGTAAAAAGAAGAGATCCAGTTCACGCAGT
CGTCATTCCAGTATCTCACCTGTCAGGCTTCCACTTAATTCCAGTCTGGGAGCTGAACTCAGTAGGAAAAAGAAGGAAAGAGCAGCTGCT
GCTGCTGCAGCAAAGATGGATGGAAAGGAGTCCAAGGGTTCACCTGTATTTTTGCCTAGAAAAGAGAACAGTTCAGTAGAGGCTAAGGAT
TCAGGTTTGGAGTCTAAAAAGTTACCCAGAAGTGTAAAATTGGAAAAATCTGCCCCAGATACTGAACTGGTGAATGTAACACATCTAAAC
ACAGAGGTAAAAAATTCTTCAGATACAGGGAAAGTAAAGTTGGATGAGAACTCCGAGAAGCATCTTGTTAAAGATTTGAAAGCACAGGGA
ACAAGAGACTCTAAACCCATAGCACTGAAAGAGGAGATTGTTACTCCAAAGGAGACAGAAACATCAGAAAAGGAGACCCCTCCACCTCTT
CCCACAATTGCTTCTCCCCCACCCCCTCTACCAACTACTACCCCTCCACCTCAGACACCCCCTTTGCCACCTTTGCCTCCAATACCAGCT
CTTCCACAGCAACCACCTCTGCCTCCTTCTCAGCCAGCATTTAGTCAGGTTCCTGCTTCCAGTACTTCAACTTTGCCCCCTTCTACTCAC
TCAAAGACATCTGCTGTGTCCTCTCAGGCAAATTCTCAGCCCCCTGTACAGGTTTCTGTGAAGACTCAAGTATCTGTAACAGCTGCTATT
CCACACCTGAAAACTTCAACGTTGCCTCCTTTGCCCCTCCCACCCTTATTACCTGGAGATGATGACATGGATAGTGAGGGATGTCCACTG
TTGGAGCAGTTGAACATTTCCTGGTGTGACCAAGTAACCAAGGATGGCATTCAAGCACTAGTGAGGGGCTGTGGGGGTCTCAAGGCCTTA
TTCTTAAAAGGCTGCACGCAGCTAGAAGATGAAGCTCTCAAGTACATAGGTGCACACTGCCCTGAACTGGTGACTTTGAACTTGCAGACT
TGCTTGCAAATCACAGATGAAGGTCTCATTACTATATGCAGAGGGTGCCATAAGTTACAATCCCTTTGTGCCTCTGGCTGCTCCAACATC
ACAGATGCCATCCTGAATGCTCTAGGTCAGAACTGCCCACGGCTTAGAATATTGGAAGTGGCAAGATGTTCTCAATTAACAGATGTGGGC
TTTACCACTCTAGCCAGGAATTGCCATGAACTTGAAAAGATGGACCTGGAAGAGTGTGTTCAGATAACAGATAGCACATTAATCCAACTT
TCTATACACTGTCCTCGACTTCAAGTATTGAGTCTGTCTCACTGTGAGCTGATCACAGATGATGGAATTCGTCACCTGGGGAATGGGGCC
TGCGCCCATGACCAGCTGGAGGTGATTGAGCTGGACAACTGCCCACTAATCACAGATGCATCCCTGGAGCACTTGAAGAGCTGTCATAGC
CTTGAGCGGATAGAACTCTATGACTGCCAGCAAATCACACGGGCTGGAATCAAGAGACTCAGGACCCATTTACCCAATATTAAAGTCCAC
GCCTACTTCGCACCTGTCACTCCACCCCCATCAGTAGGGGGCAGCAGACAGCGCTTCTGCAGATGCTGCATCATCCTATGACAATGGAGG
TGGTCAACCTTGGCGAACTGAGTATTTAATGACACTTCTAGAGCTACCGTGGAGTCTCTCCAGTGGAAGCAACCCCAGTGTTCTGAGCAA
GGGTTACAAAGTGAGGGAGGGCAGTGTCCAGATCCCCAGAGCCACACATACATACACATACACACCCTTACCCCCATCCACTCTAGCTTT
GTGACCATGGGACTGAAGTTTGTGATGGCTTTTTTATCAAGTAGATTGGTAAAATTTAACCATTCCTGTTGAGGTGCCCATAAGAAAATC
ATAGGCCAAGATAGGGAGGGGCATTCCAGCAAACCCCGTGTTAATGCTACTGTGGTTTTTAAATTTTTGTCTAGGGGTTTCTTTGGGGAT
TTTAGAACAGCATCTGCTGTCCTCCGGGGTCAAGAAAAGCATGGAAAGACAATATATGATGTACCCAGGGACCAGAAAGAAAATTTCTTT
GCATCTTAGAAATGGTAGACATTCATTGTGACTAAAGAGCTTCTATGCTTCCTTGTTTCCATGCCAACATGCTGAGCATGCTCACAAAGA
AGGCTCGTCCATTCCTCCTGTGTTTTAGTATTTGGCCCAGAGGTTTCCTAAATGGTTGCCTTGAAATCACTGTGGTCCAAATGTAATTCT
TACACACTCAAATTATCACTGTCTGTAGCACACTTGTGCACCTGTCTTACATTCTCTGTTGCTCCCCCCCACACTCTTGCTCAGTCTGTC
ACCTGTTCAGTCTGCTTACTCACTCAATTGTTACCCTTTTGCTGTTGTCGTGTTTACAGTTTGCATTTTGAATGATTAGTTGGGATTACC

>In-frame_ENST00000447079_ENST00000394294_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(amino acids)=915AA_start in transcript=33_stop in transcript=2780
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK
LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS
RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL
PLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLIT
ICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLS
LSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPS

--------------------------------------------------------------
>In-frame_ENST00000447079_ENST00000264658_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(transcript)=3654nt_BP=1964nt
CTTTTTTCCCTTCTTCAGGTCAGGGGAAAGGGAATGCCCAATTCAGAGAGACATGGGGGCAAGAAGGACGGGAGTGGAGGAGCTTCTGGA
ACTTTGCAGCCGTCATCGGGAGGCGGCAGCTCTAACAGCAGAGAGCGTCACCGCTTGGTATCGAAGCACAAGCGGCATAAGTCCAAACAC
TCCAAAGACATGGGGTTGGTGACCCCCGAAGCAGCATCCCTGGGCACAGTTATCAAACCTTTGGTGGAGTATGATGATATCAGCTCTGAT
TCCGACACCTTCTCCGATGACATGGCCTTCAAACTAGACCGAAGGGAGAACGACGAACGTCGTGGATCAGATCGGAGCGACCGCCTGCAC
AAACATCGTCACCACCAGCACAGGCGTTCCCGGGACTTACTAAAAGCTAAACAGACCGAAAAAGAAAAAAGCCAAGAAGTCTCCAGCAAG
TCGGGATCGATGAAGGACCGGATATCGGGAAGTTCAAAGCGTTCGAATGAGGAGACTGATGACTATGGGAAGGCGCAGGTAGCCAAAAGC
AGCAGCAAGGAATCCAGGTCATCCAAGCTCCACAAGGAGAAGACCAGGAAAGAACGGGAGCTGAAGTCTGGGCACAAAGACCGGAGTAAA
AGTCATCGAAAAAGGGAAACACCCAAAAGTTACAAAACAGTGGACAGCCCAAAACGGAGATCCAGGAGCCCCCACAGGAAGTGGTCTGAC
AGCTCCAAACAAGATGATAGCCCCTCGGGAGCTTCTTATGGCCAAGATTATGACCTTAGTCCCTCACGATCTCATACCTCGAGCAATTAT
GACTCCTACAAGAAAAGTCCTGGAAGTACCTCGAGAAGGCAGTCGGTCAGTCCCCCTTACAAGGAGCCTTCGGCCTACCAGTCCAGCACC
CGGTCACCGAGCCCCTACAGTAGGCGACAGAGATCTGTCAGTCCCTATAGCAGGAGACGGTCGTCCAGCTACGAAAGAAGTGGCTCTTAC
AGCGGGCGATCGCCCAGTCCCTATGGTCGAAGGCGGTCCAGCAGCCCTTTCCTGAGCAAGCGGTCTCTGAGTCGGAGTCCACTCCCCAGT
AGGAAATCCATGAAGTCCAGAAGTAGAAGTCCTGCATATTCAAGACATTCATCTTCTCATAGTAAAAAGAAGAGATCCAGTTCACGCAGT
CGTCATTCCAGTATCTCACCTGTCAGGCTTCCACTTAATTCCAGTCTGGGAGCTGAACTCAGTAGGAAAAAGAAGGAAAGAGCAGCTGCT
GCTGCTGCAGCAAAGATGGATGGAAAGGAGTCCAAGGGTTCACCTGTATTTTTGCCTAGAAAAGAGAACAGTTCAGTAGAGGCTAAGGAT
TCAGGTTTGGAGTCTAAAAAGTTACCCAGAAGTGTAAAATTGGAAAAATCTGCCCCAGATACTGAACTGGTGAATGTAACACATCTAAAC
ACAGAGGTAAAAAATTCTTCAGATACAGGGAAAGTAAAGTTGGATGAGAACTCCGAGAAGCATCTTGTTAAAGATTTGAAAGCACAGGGA
ACAAGAGACTCTAAACCCATAGCACTGAAAGAGGAGATTGTTACTCCAAAGGAGACAGAAACATCAGAAAAGGAGACCCCTCCACCTCTT
CCCACAATTGCTTCTCCCCCACCCCCTCTACCAACTACTACCCCTCCACCTCAGACACCCCCTTTGCCACCTTTGCCTCCAATACCAGCT
CTTCCACAGCAACCACCTCTGCCTCCTTCTCAGCCAGCATTTAGTCAGGTTCCTGCTTCCAGTACTTCAACTTTGCCCCCTTCTACTCAC
TCAAAGACATCTGCTGTGTCCTCTCAGGCAAATTCTCAGCCCCCTGTACAGGTTTCTGTGAAGACTCAAGTATCTGTAACAGCTGCTATT
CCACACCTGAAAACTTCAACGTTGCCTCCTTTGCCCCTCCCACCCTTATTACCTGGAGATGATGACATGGATAGTGAGGGATGTCCACTG
TTGGAGCAGTTGAACATTTCCTGGTGTGACCAAGTAACCAAGGATGGCATTCAAGCACTAGTGAGGGGCTGTGGGGGTCTCAAGGCCTTA
TTCTTAAAAGGCTGCACGCAGCTAGAAGATGAAGCTCTCAAGTACATAGGTGCACACTGCCCTGAACTGGTGACTTTGAACTTGCAGACT
TGCTTGCAAATCACAGATGAAGGTCTCATTACTATATGCAGAGGGTGCCATAAGTTACAATCCCTTTGTGCCTCTGGCTGCTCCAACATC
ACAGATGCCATCCTGAATGCTCTAGGTCAGAACTGCCCACGGCTTAGAATATTGGAAGTGGCAAGATGTTCTCAATTAACAGATGTGGGC
TTTACCACTCTAGCCAGGAATTGCCATGAACTTGAAAAGATGGACCTGGAAGAGTGTGTTCAGATAACAGATAGCACATTAATCCAACTT
TCTATACACTGTCCTCGACTTCAAGTATTGAGTCTGTCTCACTGTGAGCTGATCACAGATGATGGAATTCGTCACCTGGGGAATGGGGCC
TGCGCCCATGACCAGCTGGAGGTGATTGAGCTGGACAACTGCCCACTAATCACAGATGCATCCCTGGAGCACTTGAAGAGCTGTCATAGC
CTTGAGCGGATAGAACTCTATGACTGCCAGCAAATCACACGGGCTGGAATCAAGAGACTCAGGACCCATTTACCCAATATTAAAGTCCAC
GCCTACTTCGCACCTGTCACTCCACCCCCATCAGTAGGGGGCAGCAGACAGCGCTTCTGCAGATGCTGCATCATCCTATGACAATGGAGG
TGGTCAACCTTGGCGAACTGAGTATTTAATGACACTTCTAGAGCTACCGTGGAGTCTCTCCAGTGGAAGCAACCCCAGTGTTCTGAGCAA
GGGTTACAAAGTGAGGGAGGGCAGTGTCCAGATCCCCAGAGCCACACATACATACACATACACACCCTTACCCCCATCCACTCTAGCTTT
GTGACCATGGGACTGAAGTTTGTGATGGCTTTTTTATCAAGTAGATTGGTAAAATTTAACCATTCCTGTTGAGGTGCCCATAAGAAAATC
ATAGGCCAAGATAGGGAGGGGCATTCCAGCAAACCCCGTGTTAATGCTACTGTGGTTTTTAAATTTTTGTCTAGGGGTTTCTTTGGGGAT
TTTAGAACAGCATCTGCTGTCCTCCGGGGTCAAGAAAAGCATGGAAAGACAATATATGATGTACCCAGGGACCAGAAAGAAAATTTCTTT
GCATCTTAGAAATGGTAGACATTCATTGTGACTAAAGAGCTTCTATGCTTCCTTGTTTCCATGCCAACATGCTGAGCATGCTCACAAAGA
AGGCTCGTCCATTCCTCCTGTGTTTTAGTATTTGGCCCAGAGGTTTCCTAAATGGTTGCCTTGAAATCACTGTGGTCCAAATGTAATTCT
TACACACTCAAATTATCACTGTCTGTAGCACACTTGTGCACCTGTCTTACATTCTCTGTTGCTCCCCCCCACACTCTTGCTCAGTCTGTC
ACCTGTTCAGTCTGCTTACTCACTCAATTGTTACCCTTTTGCTGTTGTCGTGTTTACAGTTTGCATTTTGAATGATTAGTTGGGATTACC

>In-frame_ENST00000447079_ENST00000264658_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(amino acids)=915AA_start in transcript=33_stop in transcript=2780
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK
LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS
RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL
PLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLIT
ICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLS
LSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPS

--------------------------------------------------------------
>In-frame_ENST00000447079_ENST00000577399_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(transcript)=2781nt_BP=1964nt
CTTTTTTCCCTTCTTCAGGTCAGGGGAAAGGGAATGCCCAATTCAGAGAGACATGGGGGCAAGAAGGACGGGAGTGGAGGAGCTTCTGGA
ACTTTGCAGCCGTCATCGGGAGGCGGCAGCTCTAACAGCAGAGAGCGTCACCGCTTGGTATCGAAGCACAAGCGGCATAAGTCCAAACAC
TCCAAAGACATGGGGTTGGTGACCCCCGAAGCAGCATCCCTGGGCACAGTTATCAAACCTTTGGTGGAGTATGATGATATCAGCTCTGAT
TCCGACACCTTCTCCGATGACATGGCCTTCAAACTAGACCGAAGGGAGAACGACGAACGTCGTGGATCAGATCGGAGCGACCGCCTGCAC
AAACATCGTCACCACCAGCACAGGCGTTCCCGGGACTTACTAAAAGCTAAACAGACCGAAAAAGAAAAAAGCCAAGAAGTCTCCAGCAAG
TCGGGATCGATGAAGGACCGGATATCGGGAAGTTCAAAGCGTTCGAATGAGGAGACTGATGACTATGGGAAGGCGCAGGTAGCCAAAAGC
AGCAGCAAGGAATCCAGGTCATCCAAGCTCCACAAGGAGAAGACCAGGAAAGAACGGGAGCTGAAGTCTGGGCACAAAGACCGGAGTAAA
AGTCATCGAAAAAGGGAAACACCCAAAAGTTACAAAACAGTGGACAGCCCAAAACGGAGATCCAGGAGCCCCCACAGGAAGTGGTCTGAC
AGCTCCAAACAAGATGATAGCCCCTCGGGAGCTTCTTATGGCCAAGATTATGACCTTAGTCCCTCACGATCTCATACCTCGAGCAATTAT
GACTCCTACAAGAAAAGTCCTGGAAGTACCTCGAGAAGGCAGTCGGTCAGTCCCCCTTACAAGGAGCCTTCGGCCTACCAGTCCAGCACC
CGGTCACCGAGCCCCTACAGTAGGCGACAGAGATCTGTCAGTCCCTATAGCAGGAGACGGTCGTCCAGCTACGAAAGAAGTGGCTCTTAC
AGCGGGCGATCGCCCAGTCCCTATGGTCGAAGGCGGTCCAGCAGCCCTTTCCTGAGCAAGCGGTCTCTGAGTCGGAGTCCACTCCCCAGT
AGGAAATCCATGAAGTCCAGAAGTAGAAGTCCTGCATATTCAAGACATTCATCTTCTCATAGTAAAAAGAAGAGATCCAGTTCACGCAGT
CGTCATTCCAGTATCTCACCTGTCAGGCTTCCACTTAATTCCAGTCTGGGAGCTGAACTCAGTAGGAAAAAGAAGGAAAGAGCAGCTGCT
GCTGCTGCAGCAAAGATGGATGGAAAGGAGTCCAAGGGTTCACCTGTATTTTTGCCTAGAAAAGAGAACAGTTCAGTAGAGGCTAAGGAT
TCAGGTTTGGAGTCTAAAAAGTTACCCAGAAGTGTAAAATTGGAAAAATCTGCCCCAGATACTGAACTGGTGAATGTAACACATCTAAAC
ACAGAGGTAAAAAATTCTTCAGATACAGGGAAAGTAAAGTTGGATGAGAACTCCGAGAAGCATCTTGTTAAAGATTTGAAAGCACAGGGA
ACAAGAGACTCTAAACCCATAGCACTGAAAGAGGAGATTGTTACTCCAAAGGAGACAGAAACATCAGAAAAGGAGACCCCTCCACCTCTT
CCCACAATTGCTTCTCCCCCACCCCCTCTACCAACTACTACCCCTCCACCTCAGACACCCCCTTTGCCACCTTTGCCTCCAATACCAGCT
CTTCCACAGCAACCACCTCTGCCTCCTTCTCAGCCAGCATTTAGTCAGGTTCCTGCTTCCAGTACTTCAACTTTGCCCCCTTCTACTCAC
TCAAAGACATCTGCTGTGTCCTCTCAGGCAAATTCTCAGCCCCCTGTACAGGTTTCTGTGAAGACTCAAGTATCTGTAACAGCTGCTATT
CCACACCTGAAAACTTCAACGTTGCCTCCTTTGCCCCTCCCACCCTTATTACCTGGAGATGATGACATGGATAGTGAGGGATGTCCACTG
TTGGAGCAGTTGAACATTTCCTGGTGTGACCAAGTAACCAAGGATGGCATTCAAGCACTAGTGAGGGGCTGTGGGGGTCTCAAGGCCTTA
TTCTTAAAAGGCTGCACGCAGCTAGAAGATGAAGCTCTCAAGTACATAGGTGCACACTGCCCTGAACTGGTGACTTTGAACTTGCAGACT
TGCTTGCAAATCACAGATGAAGGTCTCATTACTATATGCAGAGGGTGCCATAAGTTACAATCCCTTTGTGCCTCTGGCTGCTCCAACATC
ACAGATGCCATCCTGAATGCTCTAGGTCAGAACTGCCCACGGCTTAGAATATTGGAAGTGGCAAGATGTTCTCAATTAACAGATGTGGGC
TTTACCACTCTAGCCAGGAATTGCCATGAACTTGAAAAGATGGACCTGGAAGAGTGTGTTCAGATAACAGATAGCACATTAATCCAACTT
TCTATACACTGTCCTCGACTTCAAGTATTGAGTCTGTCTCACTGTGAGCTGATCACAGATGATGGAATTCGTCACCTGGGGAATGGGGCC
TGCGCCCATGACCAGCTGGAGGTGATTGAGCTGGACAACTGCCCACTAATCACAGATGCATCCCTGGAGCACTTGAAGAGCTGTCATAGC
CTTGAGCGGATAGAACTCTATGACTGCCAGCAAATCACACGGGCTGGAATCAAGAGACTCAGGACCCATTTACCCAATATTAAAGTCCAC

>In-frame_ENST00000447079_ENST00000577399_TCGA-AO-A0JM-01A_CDK12_chr17_37628016_+_FBXL20_chr17_37439108_length(amino acids)=915AA_start in transcript=33_stop in transcript=2780
MPNSERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK
LDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLKAKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLH
KEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTS
RRQSVSPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP
AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS
VKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLP
TTTPPPQTPPLPPLPPIPALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTAAIPHLKTSTLPPL
PLPPLLPGDDDMDSEGCPLLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLIT
ICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLS
LSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKSCHSLERIELYDCQQITRAGIKRLRTHLPNIKVHAYFAPVTPPPS

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Fusion Gene PPI Analysis for CDK12-FBXL20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDK12-FBXL20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDK12-FBXL20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDK12C0033578Prostatic Neoplasms1CTD_human
HgeneCDK12C0376358Malignant neoplasm of prostate1CTD_human