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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDK14-ORC5 (FusionGDB2 ID:15220)

Fusion Gene Summary for CDK14-ORC5

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK14-ORC5
Fusion gene ID: 15220
HgeneTgene
Gene symbol

CDK14

ORC5

Gene ID

5218

5001

Gene namecyclin dependent kinase 14origin recognition complex subunit 5
SynonymsPFTAIRE1|PFTK1ORC5L|ORC5P|ORC5T|PPP1R117
Cytomap

7q21.13

7q22.1-q22.2

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 14PFTAIRE protein kinase 1cell division protein kinase 14serine/threonine-protein kinase PFTAIRE-1origin recognition complex subunit 5protein phosphatase 1, regulatory subunit 117
Modification date2020031320200313
UniProtAcc

O94921

.
Ensembl transtripts involved in fusion geneENST00000380050, ENST00000265741, 
ENST00000406263, ENST00000436577, 
ENST00000496279, 		ENST00000297431, 
ENST00000545943, ENST00000447452, 
ENST00000485726, 
Fusion gene scores* DoF score17 X 13 X 8=17687 X 6 X 7=294
# samples 1811
** MAII scorelog2(18/1768*10)=-3.29604946306176
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/294*10)=-1.4183126313117
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDK14 [Title/Abstract] AND ORC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDK14(90233563)-ORC5(103844682), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDK14

GO:0000086

G2/M transition of mitotic cell cycle

20059949

HgeneCDK14

GO:0060828

regulation of canonical Wnt signaling pathway

20059949

TgeneORC5

GO:0006275

regulation of DNA replication

31160578


check buttonFusion gene breakpoints across CDK14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ORC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-DQ-7589-01ACDK14chr7

90233563

+ORC5chr7

103844682

-
ChimerDB4HNSCTCGA-DQ-7589CDK14chr7

90233563

+ORC5chr7

103849900

-
ChimerDB4HNSCTCGA-DQ-7589CDK14chr7

90233563

+ORC5chr7

103844682

-
ChimerDB4HNSCTCGA-DQ-7589-01ACDK14chr7

90233563

-ORC5chr7

103844682

-


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Fusion Gene ORF analysis for CDK14-ORC5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000380050ENST00000297431CDK14chr7

90233563

+ORC5chr7

103844682

-
5CDS-5UTRENST00000380050ENST00000545943CDK14chr7

90233563

+ORC5chr7

103844682

-
5CDS-5UTRENST00000380050ENST00000447452CDK14chr7

90233563

+ORC5chr7

103844682

-
5CDS-5UTRENST00000380050ENST00000485726CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-3CDSENST00000265741ENST00000297431CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-5UTRENST00000265741ENST00000545943CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-5UTRENST00000265741ENST00000447452CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-5UTRENST00000265741ENST00000485726CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-3CDSENST00000406263ENST00000297431CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-5UTRENST00000406263ENST00000545943CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-5UTRENST00000406263ENST00000447452CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-5UTRENST00000406263ENST00000485726CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-3CDSENST00000436577ENST00000297431CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-5UTRENST00000436577ENST00000545943CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-5UTRENST00000436577ENST00000447452CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-5UTRENST00000436577ENST00000485726CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-3CDSENST00000496279ENST00000297431CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-5UTRENST00000496279ENST00000545943CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-5UTRENST00000496279ENST00000447452CDK14chr7

90233563

+ORC5chr7

103844682

-
intron-5UTRENST00000496279ENST00000485726CDK14chr7

90233563

+ORC5chr7

103844682

-
5CDS-intronENST00000380050ENST00000297431CDK14chr7

90233563

+ORC5chr7

103849900

-
5CDS-intronENST00000380050ENST00000545943CDK14chr7

90233563

+ORC5chr7

103849900

-
5CDS-intronENST00000380050ENST00000447452CDK14chr7

90233563

+ORC5chr7

103849900

-
5CDS-intronENST00000380050ENST00000485726CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000265741ENST00000297431CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000265741ENST00000545943CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000265741ENST00000447452CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000265741ENST00000485726CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000406263ENST00000297431CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000406263ENST00000545943CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000406263ENST00000447452CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000406263ENST00000485726CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000436577ENST00000297431CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000436577ENST00000545943CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000436577ENST00000447452CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000436577ENST00000485726CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000496279ENST00000297431CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000496279ENST00000545943CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000496279ENST00000447452CDK14chr7

90233563

+ORC5chr7

103849900

-
intron-intronENST00000496279ENST00000485726CDK14chr7

90233563

+ORC5chr7

103849900

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380050CDK14chr790233563+ENST00000297431ORC5chr7103844682-1997254771489470

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380050ENST00000297431CDK14chr790233563+ORC5chr7103844682-0.0006552780.99934477

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Fusion Genomic Features for CDK14-ORC5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDK14-ORC5


check button Go to

FGviewer for the breakpoints of chr7:90233563-chr7:103844682

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK14

O94921

.
FUNCTION: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269|PubMed:16461467, ECO:0000269|PubMed:17517622, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneORC5chr7:90233563chr7:103844682ENST0000029743101437_4424.0436.0Nucleotide bindingATP
TgeneORC5chr7:90233563chr7:103844682ENST000004474520937_4424.0325.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK14chr7:90233563chr7:103844682ENST00000265741+114135_41901522.6666666666667DomainProtein kinase
HgeneCDK14chr7:90233563chr7:103844682ENST00000380050+215135_41941.01538.0DomainProtein kinase
HgeneCDK14chr7:90233563chr7:103844682ENST00000406263+114135_41901422.0DomainProtein kinase
HgeneCDK14chr7:90233563chr7:103844682ENST00000265741+114141_14901522.6666666666667Nucleotide bindingATP
HgeneCDK14chr7:90233563chr7:103844682ENST00000380050+215141_14941.01538.0Nucleotide bindingATP
HgeneCDK14chr7:90233563chr7:103844682ENST00000406263+114141_14901422.0Nucleotide bindingATP


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Fusion Gene Sequence for CDK14-ORC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000380050_ENST00000297431_TCGA-DQ-7589-01A_CDK14_chr7_90233563_+_ORC5_chr7_103844682_length(transcript)=1997nt_BP=254nt
CGTCGCTTCCCGGCCCGCCGAGGAGGTGGTGGAGGAGGAGGCGCCGCTTTCCCCGCGGCGCGCGCCCTCGCCGTTGTCTGAGCTGTGCCT
GGACCAGTTTGGGGAAGTTGTCGGGGCTCCGCGTCGCCCAGATGTGTGACCTCATTGAGCCGCAGCCGGCCGAGAAGATCGGCAAGATGA
AGAAGTTGCGGAGAACTTTGTCGGAGAGTTTCAGTCGCATTGCTTTGAAGAAAGATGACACCACCTTTGATGAGAGACATCATTTCAGCT
TTCCATCCATTTTTATTTATGGACATACTGCTAGTGGAAAGACCTATGTAACACAAACGTTGTTGAAAACTTTAGAGCTCCCACATGTGT
TTGTGAATTGTGTTGAATGCTTTACATTGAGGCTGCTTTTGGAACAAATTTTAAACAAATTGAATCATCTTAGTTCTTCAGAGGATGGAT
GTTCTACTGAAATAACCTGTGAAACATTTAATGACTTTGTTCGCTTGTTTAAACAAGTAACCACAGCTGAAAATCTTAAAGATCAGACTG
TATATATTGTTCTAGATAAAGCAGAGTATCTAAGAGATATGGAAGCAAATCTTTTGCCTGGATTTCTTAGATTACAAGAATTGGCTGACA
GAAATGTGACTGTTCTCTTTCTCAGTGAAATTGTTTGGGAAAAGTTTCGTCCAAATACTGGATGCTTTGAGCCGTTTGTCTTATATTTCC
CTGATTACAGCATAGGCAACCTTCAAAAGATCCTGTCCCATGATCATCCTCCAGAGTATTCAGCTGATTTCTATGCTGCCTACATTAACA
TTCTTCTTGGAGTTTTCTACACTGTTTGTCGAGATTTGAAAGAGCTCAGACATCTGGCAGTACTTAATTTTCCTAAATATTGTGAACCCG
TGGTTAAAGGAGAAGCAAGTGAACGTGATACTCGCAAACTGTGGAGAAATATTGAACCTCATTTGAAGAAAGCTATGCAGACTGTTTATC
TCAGGGAAATATCAAGTTCCCAGTGGGAAAAGCTACAGAAAGATGACACAGATCCGGGGCAACTGAAAGGCCTCTCAGCGCATACTCATG
TGGAACTTCCATATTACTCTAAGTTCATTCTAATTGCTGCATACCTTGCTTCATACAATCCAGCAAGAACTGACAAGAGGTTTTTTCTTA
AGCATCATGGAAAAATCAAGAAAACCAACTTTCTAAAAAAACACGAAAAGACAAGCAATCATCTCCTTGGGCCAAAACCATTTCCACTAG
ACAGATTATTAGCAATATTATATAGTATCGTGGACAGCAGAGTTGCTCCAACAGCAAATATTTTTTCCCAGATTACCTCTCTAGTGACCC
TTCAGCTGTTAACCCTGGTTGGCCATGACGATCAGCTTGATGGACCAAAATACAAATGCACAGTGTCTCTAGACTTCATCAGAGCTATTG
CAAGGACGGTGAACTTTGACATAATAAAATACTTGTATGATTTCTTGTGAAAACAAGCTTCAAAGCCATATGGACACTGTGACAATGACT
AAGCCAAGCTGTGTTCATCCAGCTACTTAGCTGGCCAAGGAGAGGAGTTCTTTGGCTCTATTGGATTTGTCCAAACAGGTGCTGGCCCAG
CATGGAATCTGATGAAAATATTCTGATTGGTCTGGGTGGATGTGAGCAGAAGACTATTTACCAGGGACCCTGGAGTATTTGGAAGCAACG
TGTTAATTATAAACAGCAGGGTTTGAGCACAATCTGTTCTACTCTTAATGATGTTATCTTAACACTGAAATTGCCTGAAACCCATTTACT
TAGGACTACATTTTGCTCTGTGAACTATCCCCTGCGCTTTGAACGTGCCAGCAGCCCTTGTTTATATGCCCATTCTTTTCACTTCCTCTC
CACAGGAGCCTCTGCAGTCGCTTGCCAAAGCAGATTTTCCTAAGGCCACTGTTTTAAAAGATCATAGTTGCAAAATATAATAAATACAAG

>In-frame_ENST00000380050_ENST00000297431_TCGA-DQ-7589-01A_CDK14_chr7_90233563_+_ORC5_chr7_103844682_length(amino acids)=470AA_start in transcript=77_stop in transcript=1489
MSCAWTSLGKLSGLRVAQMCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDERHHFSFPSIFIYGHTASGKTYVTQTLLKTLE
LPHVFVNCVECFTLRLLLEQILNKLNHLSSSEDGCSTEITCETFNDFVRLFKQVTTAENLKDQTVYIVLDKAEYLRDMEANLLPGFLRLQ
ELADRNVTVLFLSEIVWEKFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFPK
YCEPVVKGEASERDTRKLWRNIEPHLKKAMQTVYLREISSSQWEKLQKDDTDPGQLKGLSAHTHVELPYYSKFILIAAYLASYNPARTDK
RFFLKHHGKIKKTNFLKKHEKTSNHLLGPKPFPLDRLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTLVGHDDQLDGPKYKCTVSLDF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDK14-ORC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDK14-ORC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDK14-ORC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDK14C2239176Liver carcinoma1CTD_human