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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDK16-TIMP1 (FusionGDB2 ID:15239)

Fusion Gene Summary for CDK16-TIMP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK16-TIMP1
Fusion gene ID: 15239
HgeneTgene
Gene symbol

CDK16

TIMP1

Gene ID

5127

7076

Gene namecyclin dependent kinase 16TIMP metallopeptidase inhibitor 1
SynonymsPCTAIRE|PCTAIRE1|PCTGAIRE|PCTK1CLGI|EPA|EPO|HCI|TIMP|TIMP-1
Cytomap

Xp11.3

Xp11.3

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 16PCTAIRE-motif protein kinase 1cell division protein kinase 16serine/threonine-protein kinase PCTAIRE-1testis secretory sperm-binding protein Li 224nmetalloproteinase inhibitor 1collagenase inhibitorepididymis secretory sperm binding proteinerythroid potentiating activityfibroblast collagenase inhibitortissue inhibitor of metalloproteinases 1
Modification date2020031320200315
UniProtAcc

Q00536

.
Ensembl transtripts involved in fusion geneENST00000517997, ENST00000457458, 
ENST00000357227, ENST00000518022, 
ENST00000276052, 		ENST00000218388, 
ENST00000377018, ENST00000456754, 
ENST00000377017, 
Fusion gene scores* DoF score9 X 9 X 4=3244 X 5 X 4=80
# samples 105
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDK16 [Title/Abstract] AND TIMP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDK16(47078504)-TIMP1(47444604), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTIMP1

GO:0008284

positive regulation of cell proliferation

3839290

TgeneTIMP1

GO:0010951

negative regulation of endopeptidase activity

3903517

TgeneTIMP1

GO:0043086

negative regulation of catalytic activity

3903517

TgeneTIMP1

GO:0051045

negative regulation of membrane protein ectodomain proteolysis

12714508

TgeneTIMP1

GO:1905049

negative regulation of metallopeptidase activity

9573338


check buttonFusion gene breakpoints across CDK16 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TIMP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N5-A4RD-01ACDK16chrX

47078504

+TIMP1chrX

47444604

+
ChimerDB4UCSTCGA-N5-A4RDCDK16chrX

47078504

+TIMP1chrX

47444603

+
ChimerDB4UCSTCGA-N5-A4RDCDK16chrX

47078063

+TIMP1chrX

47444603

+
ChimerDB4UCSTCGA-N5-A4RDCDK16chrX

47078504

+TIMP1chrX

47444604

+
ChimerDB4UCSTCGA-N5-A4RDCDK16chrX

47078063

+TIMP1chrX

47444604

+


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Fusion Gene ORF analysis for CDK16-TIMP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000517997ENST00000218388CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-5UTRENST00000517997ENST00000377018CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-5UTRENST00000517997ENST00000456754CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-5UTRENST00000517997ENST00000377017CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-3CDSENST00000457458ENST00000218388CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-5UTRENST00000457458ENST00000377018CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-5UTRENST00000457458ENST00000456754CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-5UTRENST00000457458ENST00000377017CDK16chrX

47078504

+TIMP1chrX

47444604

+
5UTR-3CDSENST00000357227ENST00000218388CDK16chrX

47078504

+TIMP1chrX

47444604

+
5UTR-5UTRENST00000357227ENST00000377018CDK16chrX

47078504

+TIMP1chrX

47444604

+
5UTR-5UTRENST00000357227ENST00000456754CDK16chrX

47078504

+TIMP1chrX

47444604

+
5UTR-5UTRENST00000357227ENST00000377017CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-3CDSENST00000518022ENST00000218388CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-5UTRENST00000518022ENST00000377018CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-5UTRENST00000518022ENST00000456754CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-5UTRENST00000518022ENST00000377017CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-3CDSENST00000276052ENST00000218388CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-5UTRENST00000276052ENST00000377018CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-5UTRENST00000276052ENST00000456754CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-5UTRENST00000276052ENST00000377017CDK16chrX

47078504

+TIMP1chrX

47444604

+
intron-3CDSENST00000517997ENST00000218388CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-5UTRENST00000517997ENST00000377018CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-5UTRENST00000517997ENST00000456754CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-5UTRENST00000517997ENST00000377017CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-3CDSENST00000457458ENST00000218388CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-5UTRENST00000457458ENST00000377018CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-5UTRENST00000457458ENST00000456754CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-5UTRENST00000457458ENST00000377017CDK16chrX

47078504

+TIMP1chrX

47444603

+
5UTR-3CDSENST00000357227ENST00000218388CDK16chrX

47078504

+TIMP1chrX

47444603

+
5UTR-5UTRENST00000357227ENST00000377018CDK16chrX

47078504

+TIMP1chrX

47444603

+
5UTR-5UTRENST00000357227ENST00000456754CDK16chrX

47078504

+TIMP1chrX

47444603

+
5UTR-5UTRENST00000357227ENST00000377017CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-3CDSENST00000518022ENST00000218388CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-5UTRENST00000518022ENST00000377018CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-5UTRENST00000518022ENST00000456754CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-5UTRENST00000518022ENST00000377017CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-3CDSENST00000276052ENST00000218388CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-5UTRENST00000276052ENST00000377018CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-5UTRENST00000276052ENST00000456754CDK16chrX

47078504

+TIMP1chrX

47444603

+
intron-5UTRENST00000276052ENST00000377017CDK16chrX

47078504

+TIMP1chrX

47444603

+
3UTR-3CDSENST00000517997ENST00000218388CDK16chrX

47078063

+TIMP1chrX

47444603

+
3UTR-5UTRENST00000517997ENST00000377018CDK16chrX

47078063

+TIMP1chrX

47444603

+
3UTR-5UTRENST00000517997ENST00000456754CDK16chrX

47078063

+TIMP1chrX

47444603

+
3UTR-5UTRENST00000517997ENST00000377017CDK16chrX

47078063

+TIMP1chrX

47444603

+
In-frameENST00000457458ENST00000218388CDK16chrX

47078063

+TIMP1chrX

47444603

+
5CDS-5UTRENST00000457458ENST00000377018CDK16chrX

47078063

+TIMP1chrX

47444603

+
5CDS-5UTRENST00000457458ENST00000456754CDK16chrX

47078063

+TIMP1chrX

47444603

+
5CDS-5UTRENST00000457458ENST00000377017CDK16chrX

47078063

+TIMP1chrX

47444603

+
intron-3CDSENST00000357227ENST00000218388CDK16chrX

47078063

+TIMP1chrX

47444603

+
intron-5UTRENST00000357227ENST00000377018CDK16chrX

47078063

+TIMP1chrX

47444603

+
intron-5UTRENST00000357227ENST00000456754CDK16chrX

47078063

+TIMP1chrX

47444603

+
intron-5UTRENST00000357227ENST00000377017CDK16chrX

47078063

+TIMP1chrX

47444603

+
intron-3CDSENST00000518022ENST00000218388CDK16chrX

47078063

+TIMP1chrX

47444603

+
intron-5UTRENST00000518022ENST00000377018CDK16chrX

47078063

+TIMP1chrX

47444603

+
intron-5UTRENST00000518022ENST00000456754CDK16chrX

47078063

+TIMP1chrX

47444603

+
intron-5UTRENST00000518022ENST00000377017CDK16chrX

47078063

+TIMP1chrX

47444603

+
intron-3CDSENST00000276052ENST00000218388CDK16chrX

47078063

+TIMP1chrX

47444603

+
intron-5UTRENST00000276052ENST00000377018CDK16chrX

47078063

+TIMP1chrX

47444603

+
intron-5UTRENST00000276052ENST00000456754CDK16chrX

47078063

+TIMP1chrX

47444603

+
intron-5UTRENST00000276052ENST00000377017CDK16chrX

47078063

+TIMP1chrX

47444603

+
3UTR-3CDSENST00000517997ENST00000218388CDK16chrX

47078063

+TIMP1chrX

47444604

+
3UTR-5UTRENST00000517997ENST00000377018CDK16chrX

47078063

+TIMP1chrX

47444604

+
3UTR-5UTRENST00000517997ENST00000456754CDK16chrX

47078063

+TIMP1chrX

47444604

+
3UTR-5UTRENST00000517997ENST00000377017CDK16chrX

47078063

+TIMP1chrX

47444604

+
In-frameENST00000457458ENST00000218388CDK16chrX

47078063

+TIMP1chrX

47444604

+
5CDS-5UTRENST00000457458ENST00000377018CDK16chrX

47078063

+TIMP1chrX

47444604

+
5CDS-5UTRENST00000457458ENST00000456754CDK16chrX

47078063

+TIMP1chrX

47444604

+
5CDS-5UTRENST00000457458ENST00000377017CDK16chrX

47078063

+TIMP1chrX

47444604

+
intron-3CDSENST00000357227ENST00000218388CDK16chrX

47078063

+TIMP1chrX

47444604

+
intron-5UTRENST00000357227ENST00000377018CDK16chrX

47078063

+TIMP1chrX

47444604

+
intron-5UTRENST00000357227ENST00000456754CDK16chrX

47078063

+TIMP1chrX

47444604

+
intron-5UTRENST00000357227ENST00000377017CDK16chrX

47078063

+TIMP1chrX

47444604

+
intron-3CDSENST00000518022ENST00000218388CDK16chrX

47078063

+TIMP1chrX

47444604

+
intron-5UTRENST00000518022ENST00000377018CDK16chrX

47078063

+TIMP1chrX

47444604

+
intron-5UTRENST00000518022ENST00000456754CDK16chrX

47078063

+TIMP1chrX

47444604

+
intron-5UTRENST00000518022ENST00000377017CDK16chrX

47078063

+TIMP1chrX

47444604

+
intron-3CDSENST00000276052ENST00000218388CDK16chrX

47078063

+TIMP1chrX

47444604

+
intron-5UTRENST00000276052ENST00000377018CDK16chrX

47078063

+TIMP1chrX

47444604

+
intron-5UTRENST00000276052ENST00000456754CDK16chrX

47078063

+TIMP1chrX

47444604

+
intron-5UTRENST00000276052ENST00000377017CDK16chrX

47078063

+TIMP1chrX

47444604

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000457458CDK16chrX47078063+ENST00000218388TIMP1chrX47444603+953432255854199
ENST00000457458CDK16chrX47078063+ENST00000218388TIMP1chrX47444604+953432255854199

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000457458ENST00000218388CDK16chrX47078063+TIMP1chrX47444603+0.328514220.6714857
ENST00000457458ENST00000218388CDK16chrX47078063+TIMP1chrX47444604+0.328514220.6714857

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Fusion Genomic Features for CDK16-TIMP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDK16chrX47078063+TIMP1chrX47444603+0.0078069750.99219304
CDK16chrX47078504+TIMP1chrX47444603+2.53E-060.9999975
CDK16chrX47078504+TIMP1chrX47444603+2.53E-060.9999975
CDK16chrX47078063+TIMP1chrX47444603+0.0078069750.99219304
CDK16chrX47078504+TIMP1chrX47444603+2.53E-060.9999975
CDK16chrX47078504+TIMP1chrX47444603+2.53E-060.9999975

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDK16-TIMP1


check button Go to

FGviewer for the breakpoints of chrX:47078063-chrX:47444603

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK16

Q00536

.
FUNCTION: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). {ECO:0000250, ECO:0000269|PubMed:22184064, ECO:0000269|PubMed:22796189, ECO:0000269|PubMed:22798068}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTIMP1chrX:47078063chrX:47444603ENST0000021838826179_18067.0208.0RegionInvolved in metalloproteinase-binding
TgeneTIMP1chrX:47078063chrX:47444603ENST000002183882690_9167.0208.0RegionInvolved in metalloproteinase-binding
TgeneTIMP1chrX:47078063chrX:47444604ENST0000021838826179_18067.0208.0RegionInvolved in metalloproteinase-binding
TgeneTIMP1chrX:47078063chrX:47444604ENST000002183882690_9167.0208.0RegionInvolved in metalloproteinase-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDK16chrX:47078063chrX:47444603ENST00000276052+116165_4460571.0DomainProtein kinase
HgeneCDK16chrX:47078063chrX:47444603ENST00000357227+116165_4460497.0DomainProtein kinase
HgeneCDK16chrX:47078063chrX:47444603ENST00000457458+116165_4464.0503.0DomainProtein kinase
HgeneCDK16chrX:47078063chrX:47444603ENST00000518022+116165_4460497.0DomainProtein kinase
HgeneCDK16chrX:47078063chrX:47444604ENST00000276052+116165_4460571.0DomainProtein kinase
HgeneCDK16chrX:47078063chrX:47444604ENST00000357227+116165_4460497.0DomainProtein kinase
HgeneCDK16chrX:47078063chrX:47444604ENST00000457458+116165_4464.0503.0DomainProtein kinase
HgeneCDK16chrX:47078063chrX:47444604ENST00000518022+116165_4460497.0DomainProtein kinase
HgeneCDK16chrX:47078063chrX:47444603ENST00000276052+116171_1790571.0Nucleotide bindingATP
HgeneCDK16chrX:47078063chrX:47444603ENST00000357227+116171_1790497.0Nucleotide bindingATP
HgeneCDK16chrX:47078063chrX:47444603ENST00000457458+116171_1794.0503.0Nucleotide bindingATP
HgeneCDK16chrX:47078063chrX:47444603ENST00000518022+116171_1790497.0Nucleotide bindingATP
HgeneCDK16chrX:47078063chrX:47444604ENST00000276052+116171_1790571.0Nucleotide bindingATP
HgeneCDK16chrX:47078063chrX:47444604ENST00000357227+116171_1790497.0Nucleotide bindingATP
HgeneCDK16chrX:47078063chrX:47444604ENST00000457458+116171_1794.0503.0Nucleotide bindingATP
HgeneCDK16chrX:47078063chrX:47444604ENST00000518022+116171_1790497.0Nucleotide bindingATP
TgeneTIMP1chrX:47078063chrX:47444603ENST000002183882624_14767.0208.0DomainNTR
TgeneTIMP1chrX:47078063chrX:47444604ENST000002183882624_14767.0208.0DomainNTR
TgeneTIMP1chrX:47078063chrX:47444603ENST000002183882624_2767.0208.0RegionInvolved in metalloproteinase-binding
TgeneTIMP1chrX:47078063chrX:47444604ENST000002183882624_2767.0208.0RegionInvolved in metalloproteinase-binding


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Fusion Gene Sequence for CDK16-TIMP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000457458_ENST00000218388_TCGA-N5-A4RD_CDK16_chrX_47078063_+_TIMP1_chrX_47444603_length(transcript)=953nt_BP=432nt
GGAGGGGGCAGTTGGGCGGGGATAGGCCGTCCTAGCTAAGGTGGTAAAGGCCAATAACTCTTCAGGCTGCCTCTCCTCGAAAAGTCATCT
TCTCGCGAACCTTTAAAATGCCTTCCTCCCCAAGCACCTCAAGGGACTAGAACTGAGTGCTTCATTTGTCTTTTTTCCTCCTTGCAAAAG
TCCCGTTTGCCACCATGGGGATGTACCAAGTGAGACCGAGTAGGGGGAACGAGTGGTGATTGACGCGCCAGGTTACTGGCCACTGCTCAC
CTAGGCGCTAGCAAACTTCTGCCAAGATCGGAACTGAGTACTAAACAGCCTCCACAGTTCTCCCTGGTGCCGTCTCCGGCTTGGCGCCGC
ATCCTCCTCTGGGCTCGCGATGGCCGCGTCCCCTCCCGCTGCGGACGGGTCCTTTGGTACATGCAGTCCGAGATGTATAAAGGGTTCCAA
GCCTTAGGGGATGCCGCTGACATCCGGTTCGTCTACACCCCCGCCATGGAGAGTGTCTGCGGATACTTCCACAGGTCCCACAACCGCAGC
GAGGAGTTTCTCATTGCTGGAAAACTGCAGGATGGACTCTTGCACATCACTACCTGCAGTTTTGTGGCTCCCTGGAACAGCCTGAGCTTA
GCTCAGCGCCGGGGCTTCACCAAGACCTACACTGTTGGCTGTGAGGAATGCACAGTGTTTCCCTGTTTATCCATCCCCTGCAAACTGCAG
AGTGGCACTCATTGCTTGTGGACGGACCAGCTCCTCCAAGGCTCTGAAAAGGGCTTCCAGTCCCGTCACCTTGCCTGCCTGCCTCGGGAG
CCAGGGCTGTGCACCTGGCAGTCCCTGCGGTCCCAGATAGCCTGAATCCTGCCCGGAGTGGAAGCTGAAGCCTGCACAGTGTCCACCCTG

>In-frame_ENST00000457458_ENST00000218388_TCGA-N5-A4RD_CDK16_chrX_47078063_+_TIMP1_chrX_47444603_length(amino acids)=199AA_start in transcript=255_stop in transcript=854
MATAHLGASKLLPRSELSTKQPPQFSLVPSPAWRRILLWARDGRVPSRCGRVLWYMQSEMYKGFQALGDAADIRFVYTPAMESVCGYFHR
SHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLA

--------------------------------------------------------------
>In-frame_ENST00000457458_ENST00000218388_TCGA-N5-A4RD_CDK16_chrX_47078063_+_TIMP1_chrX_47444604_length(transcript)=953nt_BP=432nt
GGAGGGGGCAGTTGGGCGGGGATAGGCCGTCCTAGCTAAGGTGGTAAAGGCCAATAACTCTTCAGGCTGCCTCTCCTCGAAAAGTCATCT
TCTCGCGAACCTTTAAAATGCCTTCCTCCCCAAGCACCTCAAGGGACTAGAACTGAGTGCTTCATTTGTCTTTTTTCCTCCTTGCAAAAG
TCCCGTTTGCCACCATGGGGATGTACCAAGTGAGACCGAGTAGGGGGAACGAGTGGTGATTGACGCGCCAGGTTACTGGCCACTGCTCAC
CTAGGCGCTAGCAAACTTCTGCCAAGATCGGAACTGAGTACTAAACAGCCTCCACAGTTCTCCCTGGTGCCGTCTCCGGCTTGGCGCCGC
ATCCTCCTCTGGGCTCGCGATGGCCGCGTCCCCTCCCGCTGCGGACGGGTCCTTTGGTACATGCAGTCCGAGATGTATAAAGGGTTCCAA
GCCTTAGGGGATGCCGCTGACATCCGGTTCGTCTACACCCCCGCCATGGAGAGTGTCTGCGGATACTTCCACAGGTCCCACAACCGCAGC
GAGGAGTTTCTCATTGCTGGAAAACTGCAGGATGGACTCTTGCACATCACTACCTGCAGTTTTGTGGCTCCCTGGAACAGCCTGAGCTTA
GCTCAGCGCCGGGGCTTCACCAAGACCTACACTGTTGGCTGTGAGGAATGCACAGTGTTTCCCTGTTTATCCATCCCCTGCAAACTGCAG
AGTGGCACTCATTGCTTGTGGACGGACCAGCTCCTCCAAGGCTCTGAAAAGGGCTTCCAGTCCCGTCACCTTGCCTGCCTGCCTCGGGAG
CCAGGGCTGTGCACCTGGCAGTCCCTGCGGTCCCAGATAGCCTGAATCCTGCCCGGAGTGGAAGCTGAAGCCTGCACAGTGTCCACCCTG

>In-frame_ENST00000457458_ENST00000218388_TCGA-N5-A4RD_CDK16_chrX_47078063_+_TIMP1_chrX_47444604_length(amino acids)=199AA_start in transcript=255_stop in transcript=854
MATAHLGASKLLPRSELSTKQPPQFSLVPSPAWRRILLWARDGRVPSRCGRVLWYMQSEMYKGFQALGDAADIRFVYTPAMESVCGYFHR
SHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLA

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Fusion Gene PPI Analysis for CDK16-TIMP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDK16-TIMP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCDK16Q00536DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneCDK16Q00536DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneCDK16Q00536DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for CDK16-TIMP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDK16C0036341Schizophrenia2PSYGENET
HgeneCDK16C3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneTIMP1C0023893Liver Cirrhosis, Experimental5CTD_human
TgeneTIMP1C0002152Alloxan Diabetes1CTD_human
TgeneTIMP1C0003504Aortic Valve Insufficiency1CTD_human
TgeneTIMP1C0004364Autoimmune Diseases1CTD_human
TgeneTIMP1C0005398Cholestasis, Extrahepatic1CTD_human
TgeneTIMP1C0006663Calcinosis1CTD_human
TgeneTIMP1C0008311Cholangitis1CTD_human
TgeneTIMP1C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneTIMP1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneTIMP1C0017661IGA Glomerulonephritis1CTD_human
TgeneTIMP1C0018799Heart Diseases1CTD_human
TgeneTIMP1C0018824Heart valve disease1CTD_human
TgeneTIMP1C0019202Hepatolenticular Degeneration1CTD_human
TgeneTIMP1C0020538Hypertensive disease1CTD_human
TgeneTIMP1C0021368Inflammation1CTD_human
TgeneTIMP1C0023891Liver Cirrhosis, Alcoholic1CTD_human
TgeneTIMP1C0027626Neoplasm Invasiveness1CTD_human
TgeneTIMP1C0029172Oral Submucous Fibrosis1CTD_human
TgeneTIMP1C0034069Pulmonary Fibrosis1CTD_human
TgeneTIMP1C0035222Respiratory Distress Syndrome, Adult1CTD_human
TgeneTIMP1C0038433Streptozotocin Diabetes1CTD_human
TgeneTIMP1C0042345Varicosity1CTD_human
TgeneTIMP1C0042373Vascular Diseases1CTD_human
TgeneTIMP1C0263628Tumoral calcinosis1CTD_human
TgeneTIMP1C0521174Microcalcification1CTD_human
TgeneTIMP1C1527352Hepatic Form of Wilson Disease1CTD_human
TgeneTIMP1C1720887Female Urogenital Diseases1CTD_human
TgeneTIMP1C4721507Alveolitis, Fibrosing1CTD_human