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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDK5RAP2-RCC1 (FusionGDB2 ID:15314)

Fusion Gene Summary for CDK5RAP2-RCC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CDK5RAP2-RCC1
Fusion gene ID: 15314
HgeneTgene
Gene symbol

CDK5RAP2

RCC1

Gene ID

55755

1104

Gene nameCDK5 regulatory subunit associated protein 2regulator of chromosome condensation 1
SynonymsC48|Cep215|MCPH3CHC1|RCC1-I|SNHG3-RCC1
Cytomap

9q33.2

1p35.3

Type of geneprotein-codingprotein-coding
DescriptionCDK5 regulatory subunit-associated protein 2CDK5 activator-binding protein C48centrosomal protein 215 kDacentrosominregulator of chromosome condensationSNHG3-RCC1 readthroughcell cycle regulatory proteinguanine nucleotide-releasing protein
Modification date2020032820200313
UniProtAcc

Q96SN8

RCC1L,WBSCR16

Ensembl transtripts involved in fusion geneENST00000360822, ENST00000359309, 
ENST00000349780, ENST00000360190, 
ENST00000480467, 		ENST00000398958, 
ENST00000373833, ENST00000373832, 
ENST00000373831, ENST00000429051, 
Fusion gene scores* DoF score12 X 13 X 5=78011 X 13 X 8=1144
# samples 1314
** MAII scorelog2(13/780*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1144*10)=-3.03058831983342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDK5RAP2 [Title/Abstract] AND RCC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDK5RAP2(123342197)-RCC1(28864343), # samples:1
CDK5RAP2(123342198)-RCC1(28864344), # samples:1
Anticipated loss of major functional domain due to fusion event.CDK5RAP2-RCC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CDK5RAP2-RCC1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CDK5RAP2-RCC1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDK5RAP2

GO:0000226

microtubule cytoskeleton organization

17959831

HgeneCDK5RAP2

GO:0001578

microtubule bundle formation

19553473

HgeneCDK5RAP2

GO:0045893

positive regulation of transcription, DNA-templated

19282672

HgeneCDK5RAP2

GO:0090266

regulation of mitotic cell cycle spindle assembly checkpoint

19282672

TgeneRCC1

GO:0007052

mitotic spindle organization

15014043

TgeneRCC1

GO:0007088

regulation of mitotic nuclear division

15014043


check buttonFusion gene breakpoints across CDK5RAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RCC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0171CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
ChimerDB4GBMTCGA-06-0171-02ACDK5RAP2chr9

123342198

-RCC1chr1

28864344

+


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Fusion Gene ORF analysis for CDK5RAP2-RCC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000360822ENST00000398958CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
In-frameENST00000360822ENST00000373833CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
Frame-shiftENST00000360822ENST00000373832CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
Frame-shiftENST00000360822ENST00000373831CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
5CDS-intronENST00000360822ENST00000429051CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
Frame-shiftENST00000359309ENST00000398958CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
In-frameENST00000359309ENST00000373833CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
Frame-shiftENST00000359309ENST00000373832CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
Frame-shiftENST00000359309ENST00000373831CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
5CDS-intronENST00000359309ENST00000429051CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
Frame-shiftENST00000349780ENST00000398958CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
In-frameENST00000349780ENST00000373833CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
Frame-shiftENST00000349780ENST00000373832CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
Frame-shiftENST00000349780ENST00000373831CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
5CDS-intronENST00000349780ENST00000429051CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
Frame-shiftENST00000360190ENST00000398958CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
In-frameENST00000360190ENST00000373833CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
Frame-shiftENST00000360190ENST00000373832CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
Frame-shiftENST00000360190ENST00000373831CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
5CDS-intronENST00000360190ENST00000429051CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
intron-3CDSENST00000480467ENST00000398958CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
intron-3CDSENST00000480467ENST00000373833CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
intron-3CDSENST00000480467ENST00000373832CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
intron-3CDSENST00000480467ENST00000373831CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
intron-intronENST00000480467ENST00000429051CDK5RAP2chr9

123342197

-RCC1chr1

28864343

+
Frame-shiftENST00000360822ENST00000398958CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
In-frameENST00000360822ENST00000373833CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
Frame-shiftENST00000360822ENST00000373832CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
Frame-shiftENST00000360822ENST00000373831CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
5CDS-intronENST00000360822ENST00000429051CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
Frame-shiftENST00000359309ENST00000398958CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
In-frameENST00000359309ENST00000373833CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
Frame-shiftENST00000359309ENST00000373832CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
Frame-shiftENST00000359309ENST00000373831CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
5CDS-intronENST00000359309ENST00000429051CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
Frame-shiftENST00000349780ENST00000398958CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
In-frameENST00000349780ENST00000373833CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
Frame-shiftENST00000349780ENST00000373832CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
Frame-shiftENST00000349780ENST00000373831CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
5CDS-intronENST00000349780ENST00000429051CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
Frame-shiftENST00000360190ENST00000398958CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
In-frameENST00000360190ENST00000373833CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
Frame-shiftENST00000360190ENST00000373832CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
Frame-shiftENST00000360190ENST00000373831CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
5CDS-intronENST00000360190ENST00000429051CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
intron-3CDSENST00000480467ENST00000398958CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
intron-3CDSENST00000480467ENST00000373833CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
intron-3CDSENST00000480467ENST00000373832CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
intron-3CDSENST00000480467ENST00000373831CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+
intron-intronENST00000480467ENST00000429051CDK5RAP2chr9

123342198

-RCC1chr1

28864344

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360822CDK5RAP2chr9123342197-ENST00000373833RCC1chr128864343+17092408251262145
ENST00000359309CDK5RAP2chr9123342197-ENST00000373833RCC1chr128864343+17092408251262145
ENST00000349780CDK5RAP2chr9123342197-ENST00000373833RCC1chr128864343+17082398241261145
ENST00000360190CDK5RAP2chr9123342197-ENST00000373833RCC1chr128864343+17082398241261145
ENST00000360822CDK5RAP2chr9123342198-ENST00000373833RCC1chr128864344+17092408251262145
ENST00000359309CDK5RAP2chr9123342198-ENST00000373833RCC1chr128864344+17092408251262145
ENST00000349780CDK5RAP2chr9123342198-ENST00000373833RCC1chr128864344+17082398241261145
ENST00000360190CDK5RAP2chr9123342198-ENST00000373833RCC1chr128864344+17082398241261145

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360822ENST00000373833CDK5RAP2chr9123342197-RCC1chr128864343+0.165327730.8346723
ENST00000359309ENST00000373833CDK5RAP2chr9123342197-RCC1chr128864343+0.165327730.8346723
ENST00000349780ENST00000373833CDK5RAP2chr9123342197-RCC1chr128864343+0.164228340.8357716
ENST00000360190ENST00000373833CDK5RAP2chr9123342197-RCC1chr128864343+0.164228340.8357716
ENST00000360822ENST00000373833CDK5RAP2chr9123342198-RCC1chr128864344+0.165327730.8346723
ENST00000359309ENST00000373833CDK5RAP2chr9123342198-RCC1chr128864344+0.165327730.8346723
ENST00000349780ENST00000373833CDK5RAP2chr9123342198-RCC1chr128864344+0.164228340.8357716
ENST00000360190ENST00000373833CDK5RAP2chr9123342198-RCC1chr128864344+0.164228340.8357716

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Fusion Genomic Features for CDK5RAP2-RCC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDK5RAP2chr9123342197-RCC1chr128864343+1.39E-091
CDK5RAP2chr9123342197-RCC1chr128864343+1.39E-091
CDK5RAP2chr9123342197-RCC1chr128864343+1.39E-091
CDK5RAP2chr9123342197-RCC1chr128864343+1.39E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDK5RAP2-RCC1


check button Go to

FGviewer for the breakpoints of chr9:123342197-chr1:28864343

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK5RAP2

Q96SN8

RCC1

RCC1L,WBSCR16

FUNCTION: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PubMed:26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697}.464

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRCC1chr9:123342197chr1:28864343ENST00000373832810363_416363.3333333333333422.0RepeatNote=RCC1 7
TgeneRCC1chr9:123342197chr1:28864343ENST000003738331113363_416363.3333333333333422.0RepeatNote=RCC1 7
TgeneRCC1chr9:123342197chr1:28864343ENST000003989581012363_416363.3333333333333422.0RepeatNote=RCC1 7
TgeneRCC1chr9:123342198chr1:28864344ENST00000373832810363_416363.3333333333333422.0RepeatNote=RCC1 7
TgeneRCC1chr9:123342198chr1:28864344ENST000003738331113363_416363.3333333333333422.0RepeatNote=RCC1 7
TgeneRCC1chr9:123342198chr1:28864344ENST000003989581012363_416363.3333333333333422.0RepeatNote=RCC1 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRCC1chr9:123342197chr1:28864343ENST000003738319114_24394.3333333333333453.0MotifBipartite nuclear localization signal
TgeneRCC1chr9:123342197chr1:28864343ENST000003738328104_24363.3333333333333422.0MotifBipartite nuclear localization signal
TgeneRCC1chr9:123342197chr1:28864343ENST0000037383311134_24363.3333333333333422.0MotifBipartite nuclear localization signal
TgeneRCC1chr9:123342197chr1:28864343ENST0000039895810124_24363.3333333333333422.0MotifBipartite nuclear localization signal
TgeneRCC1chr9:123342198chr1:28864344ENST000003738319114_24394.3333333333333453.0MotifBipartite nuclear localization signal
TgeneRCC1chr9:123342198chr1:28864344ENST000003738328104_24363.3333333333333422.0MotifBipartite nuclear localization signal
TgeneRCC1chr9:123342198chr1:28864344ENST0000037383311134_24363.3333333333333422.0MotifBipartite nuclear localization signal
TgeneRCC1chr9:123342198chr1:28864344ENST0000039895810124_24363.3333333333333422.0MotifBipartite nuclear localization signal
TgeneRCC1chr9:123342197chr1:28864343ENST00000373831911138_189394.3333333333333453.0RepeatNote=RCC1 3
TgeneRCC1chr9:123342197chr1:28864343ENST00000373831911191_257394.3333333333333453.0RepeatNote=RCC1 4
TgeneRCC1chr9:123342197chr1:28864343ENST00000373831911258_311394.3333333333333453.0RepeatNote=RCC1 5
TgeneRCC1chr9:123342197chr1:28864343ENST00000373831911312_362394.3333333333333453.0RepeatNote=RCC1 6
TgeneRCC1chr9:123342197chr1:28864343ENST0000037383191134_84394.3333333333333453.0RepeatNote=RCC1 1
TgeneRCC1chr9:123342197chr1:28864343ENST00000373831911363_416394.3333333333333453.0RepeatNote=RCC1 7
TgeneRCC1chr9:123342197chr1:28864343ENST0000037383191185_136394.3333333333333453.0RepeatNote=RCC1 2
TgeneRCC1chr9:123342197chr1:28864343ENST00000373832810138_189363.3333333333333422.0RepeatNote=RCC1 3
TgeneRCC1chr9:123342197chr1:28864343ENST00000373832810191_257363.3333333333333422.0RepeatNote=RCC1 4
TgeneRCC1chr9:123342197chr1:28864343ENST00000373832810258_311363.3333333333333422.0RepeatNote=RCC1 5
TgeneRCC1chr9:123342197chr1:28864343ENST00000373832810312_362363.3333333333333422.0RepeatNote=RCC1 6
TgeneRCC1chr9:123342197chr1:28864343ENST0000037383281034_84363.3333333333333422.0RepeatNote=RCC1 1
TgeneRCC1chr9:123342197chr1:28864343ENST0000037383281085_136363.3333333333333422.0RepeatNote=RCC1 2
TgeneRCC1chr9:123342197chr1:28864343ENST000003738331113138_189363.3333333333333422.0RepeatNote=RCC1 3
TgeneRCC1chr9:123342197chr1:28864343ENST000003738331113191_257363.3333333333333422.0RepeatNote=RCC1 4
TgeneRCC1chr9:123342197chr1:28864343ENST000003738331113258_311363.3333333333333422.0RepeatNote=RCC1 5
TgeneRCC1chr9:123342197chr1:28864343ENST000003738331113312_362363.3333333333333422.0RepeatNote=RCC1 6
TgeneRCC1chr9:123342197chr1:28864343ENST00000373833111334_84363.3333333333333422.0RepeatNote=RCC1 1
TgeneRCC1chr9:123342197chr1:28864343ENST00000373833111385_136363.3333333333333422.0RepeatNote=RCC1 2
TgeneRCC1chr9:123342197chr1:28864343ENST000003989581012138_189363.3333333333333422.0RepeatNote=RCC1 3
TgeneRCC1chr9:123342197chr1:28864343ENST000003989581012191_257363.3333333333333422.0RepeatNote=RCC1 4
TgeneRCC1chr9:123342197chr1:28864343ENST000003989581012258_311363.3333333333333422.0RepeatNote=RCC1 5
TgeneRCC1chr9:123342197chr1:28864343ENST000003989581012312_362363.3333333333333422.0RepeatNote=RCC1 6
TgeneRCC1chr9:123342197chr1:28864343ENST00000398958101234_84363.3333333333333422.0RepeatNote=RCC1 1
TgeneRCC1chr9:123342197chr1:28864343ENST00000398958101285_136363.3333333333333422.0RepeatNote=RCC1 2
TgeneRCC1chr9:123342198chr1:28864344ENST00000373831911138_189394.3333333333333453.0RepeatNote=RCC1 3
TgeneRCC1chr9:123342198chr1:28864344ENST00000373831911191_257394.3333333333333453.0RepeatNote=RCC1 4
TgeneRCC1chr9:123342198chr1:28864344ENST00000373831911258_311394.3333333333333453.0RepeatNote=RCC1 5
TgeneRCC1chr9:123342198chr1:28864344ENST00000373831911312_362394.3333333333333453.0RepeatNote=RCC1 6
TgeneRCC1chr9:123342198chr1:28864344ENST0000037383191134_84394.3333333333333453.0RepeatNote=RCC1 1
TgeneRCC1chr9:123342198chr1:28864344ENST00000373831911363_416394.3333333333333453.0RepeatNote=RCC1 7
TgeneRCC1chr9:123342198chr1:28864344ENST0000037383191185_136394.3333333333333453.0RepeatNote=RCC1 2
TgeneRCC1chr9:123342198chr1:28864344ENST00000373832810138_189363.3333333333333422.0RepeatNote=RCC1 3
TgeneRCC1chr9:123342198chr1:28864344ENST00000373832810191_257363.3333333333333422.0RepeatNote=RCC1 4
TgeneRCC1chr9:123342198chr1:28864344ENST00000373832810258_311363.3333333333333422.0RepeatNote=RCC1 5
TgeneRCC1chr9:123342198chr1:28864344ENST00000373832810312_362363.3333333333333422.0RepeatNote=RCC1 6
TgeneRCC1chr9:123342198chr1:28864344ENST0000037383281034_84363.3333333333333422.0RepeatNote=RCC1 1
TgeneRCC1chr9:123342198chr1:28864344ENST0000037383281085_136363.3333333333333422.0RepeatNote=RCC1 2
TgeneRCC1chr9:123342198chr1:28864344ENST000003738331113138_189363.3333333333333422.0RepeatNote=RCC1 3
TgeneRCC1chr9:123342198chr1:28864344ENST000003738331113191_257363.3333333333333422.0RepeatNote=RCC1 4
TgeneRCC1chr9:123342198chr1:28864344ENST000003738331113258_311363.3333333333333422.0RepeatNote=RCC1 5
TgeneRCC1chr9:123342198chr1:28864344ENST000003738331113312_362363.3333333333333422.0RepeatNote=RCC1 6
TgeneRCC1chr9:123342198chr1:28864344ENST00000373833111334_84363.3333333333333422.0RepeatNote=RCC1 1
TgeneRCC1chr9:123342198chr1:28864344ENST00000373833111385_136363.3333333333333422.0RepeatNote=RCC1 2
TgeneRCC1chr9:123342198chr1:28864344ENST000003989581012138_189363.3333333333333422.0RepeatNote=RCC1 3
TgeneRCC1chr9:123342198chr1:28864344ENST000003989581012191_257363.3333333333333422.0RepeatNote=RCC1 4
TgeneRCC1chr9:123342198chr1:28864344ENST000003989581012258_311363.3333333333333422.0RepeatNote=RCC1 5
TgeneRCC1chr9:123342198chr1:28864344ENST000003989581012312_362363.3333333333333422.0RepeatNote=RCC1 6
TgeneRCC1chr9:123342198chr1:28864344ENST00000398958101234_84363.3333333333333422.0RepeatNote=RCC1 1
TgeneRCC1chr9:123342198chr1:28864344ENST00000398958101285_136363.3333333333333422.0RepeatNote=RCC1 2


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Fusion Gene Sequence for CDK5RAP2-RCC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000360822_ENST00000373833_TCGA-06-0171_CDK5RAP2_chr9_123342197_-_RCC1_chr1_28864343_length(transcript)=1709nt_BP=240nt
AGGAAGAAGCGCCGGGAAAGATGGCGGCGTCTGTGGTTTGAATTCCAGCGGCGCCGCCAGAGTCTGAACAAGAGCTGGGGTGGAGGGGGC
GGGGACCTGGGGAGCCCGGCGGGTCGCTATCGCGGGGGGTACTAGTGGCGCCGCCGCCACAGACACCAACGCTGTCGCCACCTCTGTAGC
CATGATGGACTTGGTGTTGGAAGAGGACGTCACCGTCCCTGGGACGCTCAGCGGCTGCAGGTCGTGTTTTCGCCTGGGGCATGGGCACCA
ACTACCAGCTGGGCACAGGGCAGGATGAGGACGCCTGGAGCCCTGTGGAGATGATGGGCAAACAGCTGGAGAACCGTGTGGTCTTATCTG
TGTCCAGCGGGGGCCAGCATACAGTCTTATTAGTCAAGGACAAAGAACAGAGCTGATGAAGCCTCTGAGGGCCTGGCTTCTGTCCTGCAC
AACCTCCCTCACAGAACAGGGAAGCAGTGACAGCTGCAGATGGCAGCGGGCCTCTCCCCAGCCCTGAGCACTGTGTCAGTTCCTGCCTTT
TCTCATCAGCAGAACAGAATCCTTTTCCTCTTTTCCTTCCTCCTCTTTGGAATTTTCCTGGGACCTACAGAATAAAGGGGGGGATGGACA
GGGGGTTTTCAAAAGGAACATGGCTCACTCAGAGCTATATGGTTAGACGTTTCTCCCCTTTTCCCTACCTTCCATGGTCCTGGTTGGCCC
TGGCTTTGCCTACTAGAAAACCAAAACTTCCCCCCTGGGGTTTTGTGCCCACTCTCTGAGAAGTTGGGGCTCCATCAAGCCCCATTCTAG
TCATGTGCCCCTTTCCTGTCCCTAACAGTCCACAGGCAAACAAATGGTACAGTCATAAGAGCCATCTGTCACGGACCCACGCCCAGAGGA
ACGTGCAGAAAAAAGCAGAGCTACATGGCTGTGGGCAACTATAAGCCAAATATTTGGCTCAGAACAGGTGTCCATGGGACAAAAAAGAAC
GATCCTCCACTTGACCAAGAAAAAAGTGATTCTCCCAGAAGCACAAAGCATACTCTTGCCCCTCAGGTGTTGCTTGTGTACATCGTACCC
ATCCATTCGGCTTCACCTGCAGCCAACGGCCTGGAATCGCAAAGAGACACCACTCTGGGCAGAGCAGAGCAGGGTATGGGGTGGGGAGAG
AGGGTGGAGGGTTTTATAAACAAACTTAACAGCAATATTGAAAGGAGGTGGGGGATTGAGGGAGGGACAGAGTGTTGGAGGGCCAGAGAC
TAGTCCTGAGATGGAAACAGCAACTTGTACAGTGGCTGAGAAAATAGGATATAGTTTTGATTTTTTTAATTGTAAAATATTTTGGAGGGA
GAACAAAATCTTTTAACATTTTGAATAAATTTAGAGTTTTATAAAATAGGCCACTTGTTTTCTACACATTCCCTGCTTTTTAAGGGAGCA
CATATTATGTGCCAGGCACTGCTGGGAAAGACAGAATAAACTATAAACCTGGTGTTGAGGCTACAACTTAAGTGATGTCAAGATGTCCTG
AGGTGCCAACCAGCTGTCAGTGTGACTGTAACAAAGGCTTCAAATCTGTCAAGAAGTAAGGAAAAGTTTTGTTTGAATTTTGTTTGGGTA

>In-frame_ENST00000360822_ENST00000373833_TCGA-06-0171_CDK5RAP2_chr9_123342197_-_RCC1_chr1_28864343_length(amino acids)=145AA_start in transcript=825_stop in transcript=1262
MSLTVHRQTNGTVIRAICHGPTPRGTCRKKQSYMAVGNYKPNIWLRTGVHGTKKNDPPLDQEKSDSPRSTKHTLAPQVLLVYIVPIHSAS

--------------------------------------------------------------
>In-frame_ENST00000359309_ENST00000373833_TCGA-06-0171_CDK5RAP2_chr9_123342197_-_RCC1_chr1_28864343_length(transcript)=1709nt_BP=240nt
AGGAAGAAGCGCCGGGAAAGATGGCGGCGTCTGTGGTTTGAATTCCAGCGGCGCCGCCAGAGTCTGAACAAGAGCTGGGGTGGAGGGGGC
GGGGACCTGGGGAGCCCGGCGGGTCGCTATCGCGGGGGGTACTAGTGGCGCCGCCGCCACAGACACCAACGCTGTCGCCACCTCTGTAGC
CATGATGGACTTGGTGTTGGAAGAGGACGTCACCGTCCCTGGGACGCTCAGCGGCTGCAGGTCGTGTTTTCGCCTGGGGCATGGGCACCA
ACTACCAGCTGGGCACAGGGCAGGATGAGGACGCCTGGAGCCCTGTGGAGATGATGGGCAAACAGCTGGAGAACCGTGTGGTCTTATCTG
TGTCCAGCGGGGGCCAGCATACAGTCTTATTAGTCAAGGACAAAGAACAGAGCTGATGAAGCCTCTGAGGGCCTGGCTTCTGTCCTGCAC
AACCTCCCTCACAGAACAGGGAAGCAGTGACAGCTGCAGATGGCAGCGGGCCTCTCCCCAGCCCTGAGCACTGTGTCAGTTCCTGCCTTT
TCTCATCAGCAGAACAGAATCCTTTTCCTCTTTTCCTTCCTCCTCTTTGGAATTTTCCTGGGACCTACAGAATAAAGGGGGGGATGGACA
GGGGGTTTTCAAAAGGAACATGGCTCACTCAGAGCTATATGGTTAGACGTTTCTCCCCTTTTCCCTACCTTCCATGGTCCTGGTTGGCCC
TGGCTTTGCCTACTAGAAAACCAAAACTTCCCCCCTGGGGTTTTGTGCCCACTCTCTGAGAAGTTGGGGCTCCATCAAGCCCCATTCTAG
TCATGTGCCCCTTTCCTGTCCCTAACAGTCCACAGGCAAACAAATGGTACAGTCATAAGAGCCATCTGTCACGGACCCACGCCCAGAGGA
ACGTGCAGAAAAAAGCAGAGCTACATGGCTGTGGGCAACTATAAGCCAAATATTTGGCTCAGAACAGGTGTCCATGGGACAAAAAAGAAC
GATCCTCCACTTGACCAAGAAAAAAGTGATTCTCCCAGAAGCACAAAGCATACTCTTGCCCCTCAGGTGTTGCTTGTGTACATCGTACCC
ATCCATTCGGCTTCACCTGCAGCCAACGGCCTGGAATCGCAAAGAGACACCACTCTGGGCAGAGCAGAGCAGGGTATGGGGTGGGGAGAG
AGGGTGGAGGGTTTTATAAACAAACTTAACAGCAATATTGAAAGGAGGTGGGGGATTGAGGGAGGGACAGAGTGTTGGAGGGCCAGAGAC
TAGTCCTGAGATGGAAACAGCAACTTGTACAGTGGCTGAGAAAATAGGATATAGTTTTGATTTTTTTAATTGTAAAATATTTTGGAGGGA
GAACAAAATCTTTTAACATTTTGAATAAATTTAGAGTTTTATAAAATAGGCCACTTGTTTTCTACACATTCCCTGCTTTTTAAGGGAGCA
CATATTATGTGCCAGGCACTGCTGGGAAAGACAGAATAAACTATAAACCTGGTGTTGAGGCTACAACTTAAGTGATGTCAAGATGTCCTG
AGGTGCCAACCAGCTGTCAGTGTGACTGTAACAAAGGCTTCAAATCTGTCAAGAAGTAAGGAAAAGTTTTGTTTGAATTTTGTTTGGGTA

>In-frame_ENST00000359309_ENST00000373833_TCGA-06-0171_CDK5RAP2_chr9_123342197_-_RCC1_chr1_28864343_length(amino acids)=145AA_start in transcript=825_stop in transcript=1262
MSLTVHRQTNGTVIRAICHGPTPRGTCRKKQSYMAVGNYKPNIWLRTGVHGTKKNDPPLDQEKSDSPRSTKHTLAPQVLLVYIVPIHSAS

--------------------------------------------------------------
>In-frame_ENST00000349780_ENST00000373833_TCGA-06-0171_CDK5RAP2_chr9_123342197_-_RCC1_chr1_28864343_length(transcript)=1708nt_BP=239nt
GGAAGAAGCGCCGGGAAAGATGGCGGCGTCTGTGGTTTGAATTCCAGCGGCGCCGCCAGAGTCTGAACAAGAGCTGGGGTGGAGGGGGCG
GGGACCTGGGGAGCCCGGCGGGTCGCTATCGCGGGGGGTACTAGTGGCGCCGCCGCCACAGACACCAACGCTGTCGCCACCTCTGTAGCC
ATGATGGACTTGGTGTTGGAAGAGGACGTCACCGTCCCTGGGACGCTCAGCGGCTGCAGGTCGTGTTTTCGCCTGGGGCATGGGCACCAA
CTACCAGCTGGGCACAGGGCAGGATGAGGACGCCTGGAGCCCTGTGGAGATGATGGGCAAACAGCTGGAGAACCGTGTGGTCTTATCTGT
GTCCAGCGGGGGCCAGCATACAGTCTTATTAGTCAAGGACAAAGAACAGAGCTGATGAAGCCTCTGAGGGCCTGGCTTCTGTCCTGCACA
ACCTCCCTCACAGAACAGGGAAGCAGTGACAGCTGCAGATGGCAGCGGGCCTCTCCCCAGCCCTGAGCACTGTGTCAGTTCCTGCCTTTT
CTCATCAGCAGAACAGAATCCTTTTCCTCTTTTCCTTCCTCCTCTTTGGAATTTTCCTGGGACCTACAGAATAAAGGGGGGGATGGACAG
GGGGTTTTCAAAAGGAACATGGCTCACTCAGAGCTATATGGTTAGACGTTTCTCCCCTTTTCCCTACCTTCCATGGTCCTGGTTGGCCCT
GGCTTTGCCTACTAGAAAACCAAAACTTCCCCCCTGGGGTTTTGTGCCCACTCTCTGAGAAGTTGGGGCTCCATCAAGCCCCATTCTAGT
CATGTGCCCCTTTCCTGTCCCTAACAGTCCACAGGCAAACAAATGGTACAGTCATAAGAGCCATCTGTCACGGACCCACGCCCAGAGGAA
CGTGCAGAAAAAAGCAGAGCTACATGGCTGTGGGCAACTATAAGCCAAATATTTGGCTCAGAACAGGTGTCCATGGGACAAAAAAGAACG
ATCCTCCACTTGACCAAGAAAAAAGTGATTCTCCCAGAAGCACAAAGCATACTCTTGCCCCTCAGGTGTTGCTTGTGTACATCGTACCCA
TCCATTCGGCTTCACCTGCAGCCAACGGCCTGGAATCGCAAAGAGACACCACTCTGGGCAGAGCAGAGCAGGGTATGGGGTGGGGAGAGA
GGGTGGAGGGTTTTATAAACAAACTTAACAGCAATATTGAAAGGAGGTGGGGGATTGAGGGAGGGACAGAGTGTTGGAGGGCCAGAGACT
AGTCCTGAGATGGAAACAGCAACTTGTACAGTGGCTGAGAAAATAGGATATAGTTTTGATTTTTTTAATTGTAAAATATTTTGGAGGGAG
AACAAAATCTTTTAACATTTTGAATAAATTTAGAGTTTTATAAAATAGGCCACTTGTTTTCTACACATTCCCTGCTTTTTAAGGGAGCAC
ATATTATGTGCCAGGCACTGCTGGGAAAGACAGAATAAACTATAAACCTGGTGTTGAGGCTACAACTTAAGTGATGTCAAGATGTCCTGA
GGTGCCAACCAGCTGTCAGTGTGACTGTAACAAAGGCTTCAAATCTGTCAAGAAGTAAGGAAAAGTTTTGTTTGAATTTTGTTTGGGTAT

>In-frame_ENST00000349780_ENST00000373833_TCGA-06-0171_CDK5RAP2_chr9_123342197_-_RCC1_chr1_28864343_length(amino acids)=145AA_start in transcript=824_stop in transcript=1261
MSLTVHRQTNGTVIRAICHGPTPRGTCRKKQSYMAVGNYKPNIWLRTGVHGTKKNDPPLDQEKSDSPRSTKHTLAPQVLLVYIVPIHSAS

--------------------------------------------------------------
>In-frame_ENST00000360190_ENST00000373833_TCGA-06-0171_CDK5RAP2_chr9_123342197_-_RCC1_chr1_28864343_length(transcript)=1708nt_BP=239nt
GGAAGAAGCGCCGGGAAAGATGGCGGCGTCTGTGGTTTGAATTCCAGCGGCGCCGCCAGAGTCTGAACAAGAGCTGGGGTGGAGGGGGCG
GGGACCTGGGGAGCCCGGCGGGTCGCTATCGCGGGGGGTACTAGTGGCGCCGCCGCCACAGACACCAACGCTGTCGCCACCTCTGTAGCC
ATGATGGACTTGGTGTTGGAAGAGGACGTCACCGTCCCTGGGACGCTCAGCGGCTGCAGGTCGTGTTTTCGCCTGGGGCATGGGCACCAA
CTACCAGCTGGGCACAGGGCAGGATGAGGACGCCTGGAGCCCTGTGGAGATGATGGGCAAACAGCTGGAGAACCGTGTGGTCTTATCTGT
GTCCAGCGGGGGCCAGCATACAGTCTTATTAGTCAAGGACAAAGAACAGAGCTGATGAAGCCTCTGAGGGCCTGGCTTCTGTCCTGCACA
ACCTCCCTCACAGAACAGGGAAGCAGTGACAGCTGCAGATGGCAGCGGGCCTCTCCCCAGCCCTGAGCACTGTGTCAGTTCCTGCCTTTT
CTCATCAGCAGAACAGAATCCTTTTCCTCTTTTCCTTCCTCCTCTTTGGAATTTTCCTGGGACCTACAGAATAAAGGGGGGGATGGACAG
GGGGTTTTCAAAAGGAACATGGCTCACTCAGAGCTATATGGTTAGACGTTTCTCCCCTTTTCCCTACCTTCCATGGTCCTGGTTGGCCCT
GGCTTTGCCTACTAGAAAACCAAAACTTCCCCCCTGGGGTTTTGTGCCCACTCTCTGAGAAGTTGGGGCTCCATCAAGCCCCATTCTAGT
CATGTGCCCCTTTCCTGTCCCTAACAGTCCACAGGCAAACAAATGGTACAGTCATAAGAGCCATCTGTCACGGACCCACGCCCAGAGGAA
CGTGCAGAAAAAAGCAGAGCTACATGGCTGTGGGCAACTATAAGCCAAATATTTGGCTCAGAACAGGTGTCCATGGGACAAAAAAGAACG
ATCCTCCACTTGACCAAGAAAAAAGTGATTCTCCCAGAAGCACAAAGCATACTCTTGCCCCTCAGGTGTTGCTTGTGTACATCGTACCCA
TCCATTCGGCTTCACCTGCAGCCAACGGCCTGGAATCGCAAAGAGACACCACTCTGGGCAGAGCAGAGCAGGGTATGGGGTGGGGAGAGA
GGGTGGAGGGTTTTATAAACAAACTTAACAGCAATATTGAAAGGAGGTGGGGGATTGAGGGAGGGACAGAGTGTTGGAGGGCCAGAGACT
AGTCCTGAGATGGAAACAGCAACTTGTACAGTGGCTGAGAAAATAGGATATAGTTTTGATTTTTTTAATTGTAAAATATTTTGGAGGGAG
AACAAAATCTTTTAACATTTTGAATAAATTTAGAGTTTTATAAAATAGGCCACTTGTTTTCTACACATTCCCTGCTTTTTAAGGGAGCAC
ATATTATGTGCCAGGCACTGCTGGGAAAGACAGAATAAACTATAAACCTGGTGTTGAGGCTACAACTTAAGTGATGTCAAGATGTCCTGA
GGTGCCAACCAGCTGTCAGTGTGACTGTAACAAAGGCTTCAAATCTGTCAAGAAGTAAGGAAAAGTTTTGTTTGAATTTTGTTTGGGTAT

>In-frame_ENST00000360190_ENST00000373833_TCGA-06-0171_CDK5RAP2_chr9_123342197_-_RCC1_chr1_28864343_length(amino acids)=145AA_start in transcript=824_stop in transcript=1261
MSLTVHRQTNGTVIRAICHGPTPRGTCRKKQSYMAVGNYKPNIWLRTGVHGTKKNDPPLDQEKSDSPRSTKHTLAPQVLLVYIVPIHSAS

--------------------------------------------------------------
>In-frame_ENST00000360822_ENST00000373833_TCGA-06-0171-02A_CDK5RAP2_chr9_123342198_-_RCC1_chr1_28864344_length(transcript)=1709nt_BP=240nt
AGGAAGAAGCGCCGGGAAAGATGGCGGCGTCTGTGGTTTGAATTCCAGCGGCGCCGCCAGAGTCTGAACAAGAGCTGGGGTGGAGGGGGC
GGGGACCTGGGGAGCCCGGCGGGTCGCTATCGCGGGGGGTACTAGTGGCGCCGCCGCCACAGACACCAACGCTGTCGCCACCTCTGTAGC
CATGATGGACTTGGTGTTGGAAGAGGACGTCACCGTCCCTGGGACGCTCAGCGGCTGCAGGTCGTGTTTTCGCCTGGGGCATGGGCACCA
ACTACCAGCTGGGCACAGGGCAGGATGAGGACGCCTGGAGCCCTGTGGAGATGATGGGCAAACAGCTGGAGAACCGTGTGGTCTTATCTG
TGTCCAGCGGGGGCCAGCATACAGTCTTATTAGTCAAGGACAAAGAACAGAGCTGATGAAGCCTCTGAGGGCCTGGCTTCTGTCCTGCAC
AACCTCCCTCACAGAACAGGGAAGCAGTGACAGCTGCAGATGGCAGCGGGCCTCTCCCCAGCCCTGAGCACTGTGTCAGTTCCTGCCTTT
TCTCATCAGCAGAACAGAATCCTTTTCCTCTTTTCCTTCCTCCTCTTTGGAATTTTCCTGGGACCTACAGAATAAAGGGGGGGATGGACA
GGGGGTTTTCAAAAGGAACATGGCTCACTCAGAGCTATATGGTTAGACGTTTCTCCCCTTTTCCCTACCTTCCATGGTCCTGGTTGGCCC
TGGCTTTGCCTACTAGAAAACCAAAACTTCCCCCCTGGGGTTTTGTGCCCACTCTCTGAGAAGTTGGGGCTCCATCAAGCCCCATTCTAG
TCATGTGCCCCTTTCCTGTCCCTAACAGTCCACAGGCAAACAAATGGTACAGTCATAAGAGCCATCTGTCACGGACCCACGCCCAGAGGA
ACGTGCAGAAAAAAGCAGAGCTACATGGCTGTGGGCAACTATAAGCCAAATATTTGGCTCAGAACAGGTGTCCATGGGACAAAAAAGAAC
GATCCTCCACTTGACCAAGAAAAAAGTGATTCTCCCAGAAGCACAAAGCATACTCTTGCCCCTCAGGTGTTGCTTGTGTACATCGTACCC
ATCCATTCGGCTTCACCTGCAGCCAACGGCCTGGAATCGCAAAGAGACACCACTCTGGGCAGAGCAGAGCAGGGTATGGGGTGGGGAGAG
AGGGTGGAGGGTTTTATAAACAAACTTAACAGCAATATTGAAAGGAGGTGGGGGATTGAGGGAGGGACAGAGTGTTGGAGGGCCAGAGAC
TAGTCCTGAGATGGAAACAGCAACTTGTACAGTGGCTGAGAAAATAGGATATAGTTTTGATTTTTTTAATTGTAAAATATTTTGGAGGGA
GAACAAAATCTTTTAACATTTTGAATAAATTTAGAGTTTTATAAAATAGGCCACTTGTTTTCTACACATTCCCTGCTTTTTAAGGGAGCA
CATATTATGTGCCAGGCACTGCTGGGAAAGACAGAATAAACTATAAACCTGGTGTTGAGGCTACAACTTAAGTGATGTCAAGATGTCCTG
AGGTGCCAACCAGCTGTCAGTGTGACTGTAACAAAGGCTTCAAATCTGTCAAGAAGTAAGGAAAAGTTTTGTTTGAATTTTGTTTGGGTA

>In-frame_ENST00000360822_ENST00000373833_TCGA-06-0171-02A_CDK5RAP2_chr9_123342198_-_RCC1_chr1_28864344_length(amino acids)=145AA_start in transcript=825_stop in transcript=1262
MSLTVHRQTNGTVIRAICHGPTPRGTCRKKQSYMAVGNYKPNIWLRTGVHGTKKNDPPLDQEKSDSPRSTKHTLAPQVLLVYIVPIHSAS

--------------------------------------------------------------
>In-frame_ENST00000359309_ENST00000373833_TCGA-06-0171-02A_CDK5RAP2_chr9_123342198_-_RCC1_chr1_28864344_length(transcript)=1709nt_BP=240nt
AGGAAGAAGCGCCGGGAAAGATGGCGGCGTCTGTGGTTTGAATTCCAGCGGCGCCGCCAGAGTCTGAACAAGAGCTGGGGTGGAGGGGGC
GGGGACCTGGGGAGCCCGGCGGGTCGCTATCGCGGGGGGTACTAGTGGCGCCGCCGCCACAGACACCAACGCTGTCGCCACCTCTGTAGC
CATGATGGACTTGGTGTTGGAAGAGGACGTCACCGTCCCTGGGACGCTCAGCGGCTGCAGGTCGTGTTTTCGCCTGGGGCATGGGCACCA
ACTACCAGCTGGGCACAGGGCAGGATGAGGACGCCTGGAGCCCTGTGGAGATGATGGGCAAACAGCTGGAGAACCGTGTGGTCTTATCTG
TGTCCAGCGGGGGCCAGCATACAGTCTTATTAGTCAAGGACAAAGAACAGAGCTGATGAAGCCTCTGAGGGCCTGGCTTCTGTCCTGCAC
AACCTCCCTCACAGAACAGGGAAGCAGTGACAGCTGCAGATGGCAGCGGGCCTCTCCCCAGCCCTGAGCACTGTGTCAGTTCCTGCCTTT
TCTCATCAGCAGAACAGAATCCTTTTCCTCTTTTCCTTCCTCCTCTTTGGAATTTTCCTGGGACCTACAGAATAAAGGGGGGGATGGACA
GGGGGTTTTCAAAAGGAACATGGCTCACTCAGAGCTATATGGTTAGACGTTTCTCCCCTTTTCCCTACCTTCCATGGTCCTGGTTGGCCC
TGGCTTTGCCTACTAGAAAACCAAAACTTCCCCCCTGGGGTTTTGTGCCCACTCTCTGAGAAGTTGGGGCTCCATCAAGCCCCATTCTAG
TCATGTGCCCCTTTCCTGTCCCTAACAGTCCACAGGCAAACAAATGGTACAGTCATAAGAGCCATCTGTCACGGACCCACGCCCAGAGGA
ACGTGCAGAAAAAAGCAGAGCTACATGGCTGTGGGCAACTATAAGCCAAATATTTGGCTCAGAACAGGTGTCCATGGGACAAAAAAGAAC
GATCCTCCACTTGACCAAGAAAAAAGTGATTCTCCCAGAAGCACAAAGCATACTCTTGCCCCTCAGGTGTTGCTTGTGTACATCGTACCC
ATCCATTCGGCTTCACCTGCAGCCAACGGCCTGGAATCGCAAAGAGACACCACTCTGGGCAGAGCAGAGCAGGGTATGGGGTGGGGAGAG
AGGGTGGAGGGTTTTATAAACAAACTTAACAGCAATATTGAAAGGAGGTGGGGGATTGAGGGAGGGACAGAGTGTTGGAGGGCCAGAGAC
TAGTCCTGAGATGGAAACAGCAACTTGTACAGTGGCTGAGAAAATAGGATATAGTTTTGATTTTTTTAATTGTAAAATATTTTGGAGGGA
GAACAAAATCTTTTAACATTTTGAATAAATTTAGAGTTTTATAAAATAGGCCACTTGTTTTCTACACATTCCCTGCTTTTTAAGGGAGCA
CATATTATGTGCCAGGCACTGCTGGGAAAGACAGAATAAACTATAAACCTGGTGTTGAGGCTACAACTTAAGTGATGTCAAGATGTCCTG
AGGTGCCAACCAGCTGTCAGTGTGACTGTAACAAAGGCTTCAAATCTGTCAAGAAGTAAGGAAAAGTTTTGTTTGAATTTTGTTTGGGTA

>In-frame_ENST00000359309_ENST00000373833_TCGA-06-0171-02A_CDK5RAP2_chr9_123342198_-_RCC1_chr1_28864344_length(amino acids)=145AA_start in transcript=825_stop in transcript=1262
MSLTVHRQTNGTVIRAICHGPTPRGTCRKKQSYMAVGNYKPNIWLRTGVHGTKKNDPPLDQEKSDSPRSTKHTLAPQVLLVYIVPIHSAS

--------------------------------------------------------------
>In-frame_ENST00000349780_ENST00000373833_TCGA-06-0171-02A_CDK5RAP2_chr9_123342198_-_RCC1_chr1_28864344_length(transcript)=1708nt_BP=239nt
GGAAGAAGCGCCGGGAAAGATGGCGGCGTCTGTGGTTTGAATTCCAGCGGCGCCGCCAGAGTCTGAACAAGAGCTGGGGTGGAGGGGGCG
GGGACCTGGGGAGCCCGGCGGGTCGCTATCGCGGGGGGTACTAGTGGCGCCGCCGCCACAGACACCAACGCTGTCGCCACCTCTGTAGCC
ATGATGGACTTGGTGTTGGAAGAGGACGTCACCGTCCCTGGGACGCTCAGCGGCTGCAGGTCGTGTTTTCGCCTGGGGCATGGGCACCAA
CTACCAGCTGGGCACAGGGCAGGATGAGGACGCCTGGAGCCCTGTGGAGATGATGGGCAAACAGCTGGAGAACCGTGTGGTCTTATCTGT
GTCCAGCGGGGGCCAGCATACAGTCTTATTAGTCAAGGACAAAGAACAGAGCTGATGAAGCCTCTGAGGGCCTGGCTTCTGTCCTGCACA
ACCTCCCTCACAGAACAGGGAAGCAGTGACAGCTGCAGATGGCAGCGGGCCTCTCCCCAGCCCTGAGCACTGTGTCAGTTCCTGCCTTTT
CTCATCAGCAGAACAGAATCCTTTTCCTCTTTTCCTTCCTCCTCTTTGGAATTTTCCTGGGACCTACAGAATAAAGGGGGGGATGGACAG
GGGGTTTTCAAAAGGAACATGGCTCACTCAGAGCTATATGGTTAGACGTTTCTCCCCTTTTCCCTACCTTCCATGGTCCTGGTTGGCCCT
GGCTTTGCCTACTAGAAAACCAAAACTTCCCCCCTGGGGTTTTGTGCCCACTCTCTGAGAAGTTGGGGCTCCATCAAGCCCCATTCTAGT
CATGTGCCCCTTTCCTGTCCCTAACAGTCCACAGGCAAACAAATGGTACAGTCATAAGAGCCATCTGTCACGGACCCACGCCCAGAGGAA
CGTGCAGAAAAAAGCAGAGCTACATGGCTGTGGGCAACTATAAGCCAAATATTTGGCTCAGAACAGGTGTCCATGGGACAAAAAAGAACG
ATCCTCCACTTGACCAAGAAAAAAGTGATTCTCCCAGAAGCACAAAGCATACTCTTGCCCCTCAGGTGTTGCTTGTGTACATCGTACCCA
TCCATTCGGCTTCACCTGCAGCCAACGGCCTGGAATCGCAAAGAGACACCACTCTGGGCAGAGCAGAGCAGGGTATGGGGTGGGGAGAGA
GGGTGGAGGGTTTTATAAACAAACTTAACAGCAATATTGAAAGGAGGTGGGGGATTGAGGGAGGGACAGAGTGTTGGAGGGCCAGAGACT
AGTCCTGAGATGGAAACAGCAACTTGTACAGTGGCTGAGAAAATAGGATATAGTTTTGATTTTTTTAATTGTAAAATATTTTGGAGGGAG
AACAAAATCTTTTAACATTTTGAATAAATTTAGAGTTTTATAAAATAGGCCACTTGTTTTCTACACATTCCCTGCTTTTTAAGGGAGCAC
ATATTATGTGCCAGGCACTGCTGGGAAAGACAGAATAAACTATAAACCTGGTGTTGAGGCTACAACTTAAGTGATGTCAAGATGTCCTGA
GGTGCCAACCAGCTGTCAGTGTGACTGTAACAAAGGCTTCAAATCTGTCAAGAAGTAAGGAAAAGTTTTGTTTGAATTTTGTTTGGGTAT

>In-frame_ENST00000349780_ENST00000373833_TCGA-06-0171-02A_CDK5RAP2_chr9_123342198_-_RCC1_chr1_28864344_length(amino acids)=145AA_start in transcript=824_stop in transcript=1261
MSLTVHRQTNGTVIRAICHGPTPRGTCRKKQSYMAVGNYKPNIWLRTGVHGTKKNDPPLDQEKSDSPRSTKHTLAPQVLLVYIVPIHSAS

--------------------------------------------------------------
>In-frame_ENST00000360190_ENST00000373833_TCGA-06-0171-02A_CDK5RAP2_chr9_123342198_-_RCC1_chr1_28864344_length(transcript)=1708nt_BP=239nt
GGAAGAAGCGCCGGGAAAGATGGCGGCGTCTGTGGTTTGAATTCCAGCGGCGCCGCCAGAGTCTGAACAAGAGCTGGGGTGGAGGGGGCG
GGGACCTGGGGAGCCCGGCGGGTCGCTATCGCGGGGGGTACTAGTGGCGCCGCCGCCACAGACACCAACGCTGTCGCCACCTCTGTAGCC
ATGATGGACTTGGTGTTGGAAGAGGACGTCACCGTCCCTGGGACGCTCAGCGGCTGCAGGTCGTGTTTTCGCCTGGGGCATGGGCACCAA
CTACCAGCTGGGCACAGGGCAGGATGAGGACGCCTGGAGCCCTGTGGAGATGATGGGCAAACAGCTGGAGAACCGTGTGGTCTTATCTGT
GTCCAGCGGGGGCCAGCATACAGTCTTATTAGTCAAGGACAAAGAACAGAGCTGATGAAGCCTCTGAGGGCCTGGCTTCTGTCCTGCACA
ACCTCCCTCACAGAACAGGGAAGCAGTGACAGCTGCAGATGGCAGCGGGCCTCTCCCCAGCCCTGAGCACTGTGTCAGTTCCTGCCTTTT
CTCATCAGCAGAACAGAATCCTTTTCCTCTTTTCCTTCCTCCTCTTTGGAATTTTCCTGGGACCTACAGAATAAAGGGGGGGATGGACAG
GGGGTTTTCAAAAGGAACATGGCTCACTCAGAGCTATATGGTTAGACGTTTCTCCCCTTTTCCCTACCTTCCATGGTCCTGGTTGGCCCT
GGCTTTGCCTACTAGAAAACCAAAACTTCCCCCCTGGGGTTTTGTGCCCACTCTCTGAGAAGTTGGGGCTCCATCAAGCCCCATTCTAGT
CATGTGCCCCTTTCCTGTCCCTAACAGTCCACAGGCAAACAAATGGTACAGTCATAAGAGCCATCTGTCACGGACCCACGCCCAGAGGAA
CGTGCAGAAAAAAGCAGAGCTACATGGCTGTGGGCAACTATAAGCCAAATATTTGGCTCAGAACAGGTGTCCATGGGACAAAAAAGAACG
ATCCTCCACTTGACCAAGAAAAAAGTGATTCTCCCAGAAGCACAAAGCATACTCTTGCCCCTCAGGTGTTGCTTGTGTACATCGTACCCA
TCCATTCGGCTTCACCTGCAGCCAACGGCCTGGAATCGCAAAGAGACACCACTCTGGGCAGAGCAGAGCAGGGTATGGGGTGGGGAGAGA
GGGTGGAGGGTTTTATAAACAAACTTAACAGCAATATTGAAAGGAGGTGGGGGATTGAGGGAGGGACAGAGTGTTGGAGGGCCAGAGACT
AGTCCTGAGATGGAAACAGCAACTTGTACAGTGGCTGAGAAAATAGGATATAGTTTTGATTTTTTTAATTGTAAAATATTTTGGAGGGAG
AACAAAATCTTTTAACATTTTGAATAAATTTAGAGTTTTATAAAATAGGCCACTTGTTTTCTACACATTCCCTGCTTTTTAAGGGAGCAC
ATATTATGTGCCAGGCACTGCTGGGAAAGACAGAATAAACTATAAACCTGGTGTTGAGGCTACAACTTAAGTGATGTCAAGATGTCCTGA
GGTGCCAACCAGCTGTCAGTGTGACTGTAACAAAGGCTTCAAATCTGTCAAGAAGTAAGGAAAAGTTTTGTTTGAATTTTGTTTGGGTAT

>In-frame_ENST00000360190_ENST00000373833_TCGA-06-0171-02A_CDK5RAP2_chr9_123342198_-_RCC1_chr1_28864344_length(amino acids)=145AA_start in transcript=824_stop in transcript=1261
MSLTVHRQTNGTVIRAICHGPTPRGTCRKKQSYMAVGNYKPNIWLRTGVHGTKKNDPPLDQEKSDSPRSTKHTLAPQVLLVYIVPIHSAS

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Fusion Gene PPI Analysis for CDK5RAP2-RCC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000349780-1381726_176819.6666666666666681894.0CDK5R1
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000359309-1371726_176819.6666666666666681853.0CDK5R1
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000360190-1371726_176819.6666666666666681815.0CDK5R1
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000360822-1371726_176819.6666666666666681862.0CDK5R1
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000349780-1381726_176819.6666666666666681894.0CDK5R1
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000359309-1371726_176819.6666666666666681853.0CDK5R1
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000360190-1371726_176819.6666666666666681815.0CDK5R1
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000360822-1371726_176819.6666666666666681862.0CDK5R1
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000349780-138926_120819.6666666666666681894.0MAPRE1
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000359309-137926_120819.6666666666666681853.0MAPRE1
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000360190-137926_120819.6666666666666681815.0MAPRE1
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000360822-137926_120819.6666666666666681862.0MAPRE1
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000349780-138926_120819.6666666666666681894.0MAPRE1
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000359309-137926_120819.6666666666666681853.0MAPRE1
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000360190-137926_120819.6666666666666681815.0MAPRE1
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000360822-137926_120819.6666666666666681862.0MAPRE1
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000349780-13858_19619.6666666666666681894.0NCKAP5L
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000359309-13758_19619.6666666666666681853.0NCKAP5L
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000360190-13758_19619.6666666666666681815.0NCKAP5L
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000360822-13758_19619.6666666666666681862.0NCKAP5L
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000349780-13858_19619.6666666666666681894.0NCKAP5L
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000359309-13758_19619.6666666666666681853.0NCKAP5L
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000360190-13758_19619.6666666666666681815.0NCKAP5L
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000360822-13758_19619.6666666666666681862.0NCKAP5L
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000349780-1381726_189319.6666666666666681894.0PCNT and AKAP9
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000359309-1371726_189319.6666666666666681853.0PCNT and AKAP9
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000360190-1371726_189319.6666666666666681815.0PCNT and AKAP9
HgeneCDK5RAP2chr9:123342197chr1:28864343ENST00000360822-1371726_189319.6666666666666681862.0PCNT and AKAP9
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000349780-1381726_189319.6666666666666681894.0PCNT and AKAP9
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000359309-1371726_189319.6666666666666681853.0PCNT and AKAP9
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000360190-1371726_189319.6666666666666681815.0PCNT and AKAP9
HgeneCDK5RAP2chr9:123342198chr1:28864344ENST00000360822-1371726_189319.6666666666666681862.0PCNT and AKAP9


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDK5RAP2-RCC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDK5RAP2-RCC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource