FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CDKAL1-CRHR2 (FusionGDB2 ID:15363)

Fusion Gene Summary for CDKAL1-CRHR2

check button Fusion gene summary
Fusion gene informationFusion gene name: CDKAL1-CRHR2
Fusion gene ID: 15363
HgeneTgene
Gene symbol

CDKAL1

CRHR2

Gene ID

54901

1395

Gene nameCDK5 regulatory subunit associated protein 1 like 1corticotropin releasing hormone receptor 2
Synonyms-CRF-RB|CRF2|CRFR2|HM-CRF
Cytomap

6p22.3

7p14.3

Type of geneprotein-codingprotein-coding
Descriptionthreonylcarbamoyladenosine tRNA methylthiotransferasetRNA-t(6)A37 methylthiotransferasecorticotropin-releasing factor receptor 2CRF2 receptor, beta isoformCRH receptor 2 variant BCRH-R2
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000274695, ENST00000378624, 
ENST00000378610, ENST00000476517, 
ENST00000471646, ENST00000341843, 
ENST00000348438, ENST00000506074, 
ENST00000462882, 
Fusion gene scores* DoF score37 X 20 X 14=103603 X 3 X 2=18
# samples 393
** MAII scorelog2(39/10360*10)=-4.73140606882431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDKAL1 [Title/Abstract] AND CRHR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDKAL1(21108694)-CRHR2(30695628), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CDKAL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CRHR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-G3-A7M5-01ACDKAL1chr6

21108694

+CRHR2chr7

30695628

-
ChimerDB4LIHCTCGA-G3-A7M5-01ACDKAL1chr6

21108694

-CRHR2chr7

30695628

-


Top

Fusion Gene ORF analysis for CDKAL1-CRHR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000274695ENST00000471646CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
In-frameENST00000274695ENST00000341843CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
In-frameENST00000274695ENST00000348438CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
In-frameENST00000274695ENST00000506074CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
5CDS-intronENST00000274695ENST00000462882CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
intron-3CDSENST00000378624ENST00000471646CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
intron-3CDSENST00000378624ENST00000341843CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
intron-3CDSENST00000378624ENST00000348438CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
intron-3CDSENST00000378624ENST00000506074CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
intron-intronENST00000378624ENST00000462882CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
In-frameENST00000378610ENST00000471646CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
In-frameENST00000378610ENST00000341843CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
In-frameENST00000378610ENST00000348438CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
In-frameENST00000378610ENST00000506074CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
5CDS-intronENST00000378610ENST00000462882CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
intron-3CDSENST00000476517ENST00000471646CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
intron-3CDSENST00000476517ENST00000341843CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
intron-3CDSENST00000476517ENST00000348438CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
intron-3CDSENST00000476517ENST00000506074CDKAL1chr6

21108694

+CRHR2chr7

30695628

-
intron-intronENST00000476517ENST00000462882CDKAL1chr6

21108694

+CRHR2chr7

30695628

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000274695CDKAL1chr621108694+ENST00000471646CRHR2chr730695628-274714661671870567
ENST00000274695CDKAL1chr621108694+ENST00000341843CRHR2chr730695628-208414661671870567
ENST00000274695CDKAL1chr621108694+ENST00000348438CRHR2chr730695628-208414661671870567
ENST00000274695CDKAL1chr621108694+ENST00000506074CRHR2chr730695628-205514661671747526
ENST00000378610CDKAL1chr621108694+ENST00000471646CRHR2chr730695628-25901309101713567
ENST00000378610CDKAL1chr621108694+ENST00000341843CRHR2chr730695628-19271309101713567
ENST00000378610CDKAL1chr621108694+ENST00000348438CRHR2chr730695628-19271309101713567
ENST00000378610CDKAL1chr621108694+ENST00000506074CRHR2chr730695628-18981309101590526

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000274695ENST00000471646CDKAL1chr621108694+CRHR2chr730695628-0.0009938630.9990062
ENST00000274695ENST00000341843CDKAL1chr621108694+CRHR2chr730695628-0.0005510780.99944896
ENST00000274695ENST00000348438CDKAL1chr621108694+CRHR2chr730695628-0.0005510780.99944896
ENST00000274695ENST00000506074CDKAL1chr621108694+CRHR2chr730695628-0.0004921640.9995078
ENST00000378610ENST00000471646CDKAL1chr621108694+CRHR2chr730695628-0.0012761320.9987238
ENST00000378610ENST00000341843CDKAL1chr621108694+CRHR2chr730695628-0.0007672730.99923277
ENST00000378610ENST00000348438CDKAL1chr621108694+CRHR2chr730695628-0.0007672730.99923277
ENST00000378610ENST00000506074CDKAL1chr621108694+CRHR2chr730695628-0.0006857320.9993143

Top

Fusion Genomic Features for CDKAL1-CRHR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CDKAL1-CRHR2


check button Go to

FGviewer for the breakpoints of chr6:21108694-chr7:30695628

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000274695+1316200_431433.0580.0DomainRadical SAM core
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000274695+131664_172433.0580.0DomainMTTase N-terminal
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378610+1114200_431433.0580.0DomainRadical SAM core
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378610+111464_172433.0580.0DomainMTTase N-terminal
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712292_302263.0398.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712328_334263.0398.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712365_411263.0398.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813328_334304.0439.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813365_411304.0439.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712292_302277.0412.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712328_334277.0412.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712365_411277.0412.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712266_291263.0398.0TransmembraneHelical%3B Name%3D5
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712303_327263.0398.0TransmembraneHelical%3B Name%3D6
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712335_364263.0398.0TransmembraneHelical%3B Name%3D7
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813303_327304.0439.0TransmembraneHelical%3B Name%3D6
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813335_364304.0439.0TransmembraneHelical%3B Name%3D7
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712303_327277.0412.0TransmembraneHelical%3B Name%3D6
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712335_364277.0412.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000274695+1316431_493433.0580.0DomainTRAM
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378610+1114431_493433.0580.0DomainTRAM
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378624+114200_4310489.0DomainRadical SAM core
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378624+114431_4930489.0DomainTRAM
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378624+11464_1720489.0DomainMTTase N-terminal
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000274695+1316556_578433.0580.0TransmembraneHelical
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378610+1114556_578433.0580.0TransmembraneHelical
HgeneCDKAL1chr6:21108694chr7:30695628ENST00000378624+114556_5780489.0TransmembraneHelical
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712140_146263.0398.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712172_185263.0398.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST000003418437121_108263.0398.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712215_221263.0398.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712250_265263.0398.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813140_146304.0439.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813172_185304.0439.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST000003484388131_108304.0439.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813215_221304.0439.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813250_265304.0439.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813292_302304.0439.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712140_146277.0412.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712172_185277.0412.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST000004716467121_108277.0412.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712215_221277.0412.0Topological domainCytoplasmic
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712250_265277.0412.0Topological domainExtracellular
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712109_139263.0398.0TransmembraneHelical%3B Name%3D1
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712147_171263.0398.0TransmembraneHelical%3B Name%3D2
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712186_214263.0398.0TransmembraneHelical%3B Name%3D3
TgeneCRHR2chr6:21108694chr7:30695628ENST00000341843712222_249263.0398.0TransmembraneHelical%3B Name%3D4
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813109_139304.0439.0TransmembraneHelical%3B Name%3D1
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813147_171304.0439.0TransmembraneHelical%3B Name%3D2
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813186_214304.0439.0TransmembraneHelical%3B Name%3D3
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813222_249304.0439.0TransmembraneHelical%3B Name%3D4
TgeneCRHR2chr6:21108694chr7:30695628ENST00000348438813266_291304.0439.0TransmembraneHelical%3B Name%3D5
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712109_139277.0412.0TransmembraneHelical%3B Name%3D1
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712147_171277.0412.0TransmembraneHelical%3B Name%3D2
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712186_214277.0412.0TransmembraneHelical%3B Name%3D3
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712222_249277.0412.0TransmembraneHelical%3B Name%3D4
TgeneCRHR2chr6:21108694chr7:30695628ENST00000471646712266_291277.0412.0TransmembraneHelical%3B Name%3D5


Top

Fusion Gene Sequence for CDKAL1-CRHR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000274695_ENST00000471646_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(transcript)=2747nt_BP=1466nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGCACTATTCCAGGCATACAGA
AAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCTAGCTGCTTATGGCTATAAAATTA
CAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAA
AAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCA
TTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAGACTGCTGGGTCAGAAAAAGGATA
ATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAATCATTTCCATCAATACCGGGTGTC
TCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGAACTAGTAGATAGAGCCAAACAAT
CTTTTCAAGAGGGTGTTTGTGAGATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATATTGGCACCAATCTCCCCACACTCC
TGTGGAAACTGGTTGAAGTGATTCCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTATATTTTAGAGCATCTGGAGGAAA
TGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAA
GAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTG
GTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTT
ACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCAGCACAAGTGAAAAAGCAAAGGACAAAAGATCTTTCTCGGGTGTTTC
ATTCTTACAGTCCATATGATCACAAGATCAATTTCGTATTTCTGTTCAACATCGTCAGGATCCTAATGACAAAGTTACGCGCGTCCACCA
CATCCGAGACAATCCAGTACAGGAAGGCAGTGAAGGCCACCCTGGTGCTCCTGCCCCTCCTGGGCATCACCTACATGCTCTTCTTCGTCA
ATCCCGGGGAGGACGACCTGTCACAGATCATGTTCATCTATTTCAACTCCTTCCTGCAGTCGTTCCAGGGTTTCTTCGTGTCTGTCTTCT
ACTGCTTCTTCAATGGAGAGGTGCGCTCAGCCGTGAGGAAGAGGTGGCACCGCTGGCAGGACCATCACTCCCTTCGAGTCCCCATGGCCC
GGGCCATGTCCATCCCTACATCACCCACACGGATCAGCTTCCACAGCATCAAGCAGACGGCCGCTGTGTGACCCCTCGGTCGCCCACCTG
CACAGCTCCCCTGTCCTCCTCCACCTTCTTCCTCTGGGTTCTCTGTGCTGGGCAGGCTCTCGTGGGGCAGGAGATGGGAGGGGAGAGACC
AGCTCTCCAGCCTGGCAGGAAAGAGGGGGTGCGGCAGCCAAGGGGGACTGCAAGGGACAGGGATGAGTGGGGGCCACCAGGCTCAGCGCA
AGAGGAAGCAGAGGGAATTCACAGGACCCCCTGAGAAGAGCCAGTCAGATGTCTGCAGGCATTTGCCCATCCCAGCCTCTCTGGCCAGGG
CCTTACTGGGCCCAGAGCAGAGAAGGACCTGTCCAACACACACAGCTATTTATAGTAGCAGACACAGGGCTCCCCTGCCCTACTCATGGA
GCCAGCAGCCAGGCAATGGTGTGGCCCTGCACTGGCCCTTGGCCTCCACACTCAGTGGTGCCCCTGCAGTTGGGTGGGGTACGCCAGCAA
AGGATCAGTTTGGCTGCCTTATCCCAGGGGCTGTCACCTAGAGAGGCTCACTTGTACCCCACCCTTGTTCCTGTGTCCCCTCCCCAGCCA
TCCTCCCGCCTTGGGGGCTCCATGAAGGATGCAGGCTTCCAGGCCTGGCTTCCTCTCTTGGGAGACCCCTTCTCTGCCTAGTCCACAGAT
TAGGCAATCAAGGAAGACGCCATCAGGGAAGCCACATCCTTAGTCAACCAGTTGCATCGTGCGGGGCAAAATGAGGAGCAGAGGCATGGA
GGAGGGAGGCGTGGGATGGGAATAGCAGAAACCAACCATGTCTTCAGTGATTGAAACTCATACCCCATTGCCCTTTGCCCTCCAGTCTCC

>In-frame_ENST00000274695_ENST00000471646_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(amino acids)=567AA_start in transcript=167_stop in transcript=1870
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL
RASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLR

--------------------------------------------------------------
>In-frame_ENST00000274695_ENST00000341843_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(transcript)=2084nt_BP=1466nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGCACTATTCCAGGCATACAGA
AAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCTAGCTGCTTATGGCTATAAAATTA
CAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAA
AAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCA
TTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAGACTGCTGGGTCAGAAAAAGGATA
ATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAATCATTTCCATCAATACCGGGTGTC
TCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGAACTAGTAGATAGAGCCAAACAAT
CTTTTCAAGAGGGTGTTTGTGAGATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATATTGGCACCAATCTCCCCACACTCC
TGTGGAAACTGGTTGAAGTGATTCCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTATATTTTAGAGCATCTGGAGGAAA
TGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAA
GAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTG
GTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTT
ACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCAGCACAAGTGAAAAAGCAAAGGACAAAAGATCTTTCTCGGGTGTTTC
ATTCTTACAGTCCATATGATCACAAGATCAATTTCGTATTTCTGTTCAACATCGTCAGGATCCTAATGACAAAGTTACGCGCGTCCACCA
CATCCGAGACAATCCAGTACAGGAAGGCAGTGAAGGCCACCCTGGTGCTCCTGCCCCTCCTGGGCATCACCTACATGCTCTTCTTCGTCA
ATCCCGGGGAGGACGACCTGTCACAGATCATGTTCATCTATTTCAACTCCTTCCTGCAGTCGTTCCAGGGTTTCTTCGTGTCTGTCTTCT
ACTGCTTCTTCAATGGAGAGGTGCGCTCAGCCGTGAGGAAGAGGTGGCACCGCTGGCAGGACCATCACTCCCTTCGAGTCCCCATGGCCC
GGGCCATGTCCATCCCTACATCACCCACACGGATCAGCTTCCACAGCATCAAGCAGACGGCCGCTGTGTGACCCCTCGGTCGCCCACCTG
CACAGCTCCCCTGTCCTCCTCCACCTTCTTCCTCTGGGTTCTCTGTGCTGGGCAGGCTCTCGTGGGGCAGGAGATGGGAGGGGAGAGACC
AGCTCTCCAGCCTGGCAGGAAAGAGGGGGTGCGGCAGCCAAGGGGGACTGCAAGGGACAGGGATGAGTGGGGGCCACCAGGCTCAGCGCA

>In-frame_ENST00000274695_ENST00000341843_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(amino acids)=567AA_start in transcript=167_stop in transcript=1870
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL
RASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLR

--------------------------------------------------------------
>In-frame_ENST00000274695_ENST00000348438_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(transcript)=2084nt_BP=1466nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGCACTATTCCAGGCATACAGA
AAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCTAGCTGCTTATGGCTATAAAATTA
CAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAA
AAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCA
TTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAGACTGCTGGGTCAGAAAAAGGATA
ATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAATCATTTCCATCAATACCGGGTGTC
TCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGAACTAGTAGATAGAGCCAAACAAT
CTTTTCAAGAGGGTGTTTGTGAGATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATATTGGCACCAATCTCCCCACACTCC
TGTGGAAACTGGTTGAAGTGATTCCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTATATTTTAGAGCATCTGGAGGAAA
TGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAA
GAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTG
GTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTT
ACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCAGCACAAGTGAAAAAGCAAAGGACAAAAGATCTTTCTCGGGTGTTTC
ATTCTTACAGTCCATATGATCACAAGATCAATTTCGTATTTCTGTTCAACATCGTCAGGATCCTAATGACAAAGTTACGCGCGTCCACCA
CATCCGAGACAATCCAGTACAGGAAGGCAGTGAAGGCCACCCTGGTGCTCCTGCCCCTCCTGGGCATCACCTACATGCTCTTCTTCGTCA
ATCCCGGGGAGGACGACCTGTCACAGATCATGTTCATCTATTTCAACTCCTTCCTGCAGTCGTTCCAGGGTTTCTTCGTGTCTGTCTTCT
ACTGCTTCTTCAATGGAGAGGTGCGCTCAGCCGTGAGGAAGAGGTGGCACCGCTGGCAGGACCATCACTCCCTTCGAGTCCCCATGGCCC
GGGCCATGTCCATCCCTACATCACCCACACGGATCAGCTTCCACAGCATCAAGCAGACGGCCGCTGTGTGACCCCTCGGTCGCCCACCTG
CACAGCTCCCCTGTCCTCCTCCACCTTCTTCCTCTGGGTTCTCTGTGCTGGGCAGGCTCTCGTGGGGCAGGAGATGGGAGGGGAGAGACC
AGCTCTCCAGCCTGGCAGGAAAGAGGGGGTGCGGCAGCCAAGGGGGACTGCAAGGGACAGGGATGAGTGGGGGCCACCAGGCTCAGCGCA

>In-frame_ENST00000274695_ENST00000348438_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(amino acids)=567AA_start in transcript=167_stop in transcript=1870
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL
RASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLR

--------------------------------------------------------------
>In-frame_ENST00000274695_ENST00000506074_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(transcript)=2055nt_BP=1466nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGCACTATTCCAGGCATACAGA
AAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCTAGCTGCTTATGGCTATAAAATTA
CAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAA
AAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCA
TTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAGACTGCTGGGTCAGAAAAAGGATA
ATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAATCATTTCCATCAATACCGGGTGTC
TCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGAACTAGTAGATAGAGCCAAACAAT
CTTTTCAAGAGGGTGTTTGTGAGATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATATTGGCACCAATCTCCCCACACTCC
TGTGGAAACTGGTTGAAGTGATTCCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTATATTTTAGAGCATCTGGAGGAAA
TGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAA
GAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTG
GTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTT
ACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCAGCACAAGTGAAAAAGCAAAGGACAAAAGATCTTTCTCGGGTGTTTC
ATTCTTACAGTCCATATGATCACAAGATCAATTTCGTATTTCTGTTCAACATCGTCAGGATCCTAATGACAAAGTTACGCGCGTCCACCA
CATCCGAGACAATCCAGTACAGGAAGGCAGTGAAGGCCACCCTGGTGCTCCTGCCCCTCCTGGGCATCACCTACATGCTCTTCTTCGTCA
ATCCCGGGGAGGACGACCTGTCACAGATCATGTTCATCTATTTCAACTCCTTCCTGCAGTCGTTCCAGGGTTTCTTCGTGTCTGTCTTCT
ACTGCTTCTTCAATGGAGAGGGGCTGGAGCCAGTTTAGAAGGTCAACTATGCAGCCCCGAAATAACATGCCAGCACCCCACATGTGCACT
CAGAGCTGGGTGAGCAAGGAAGCCCAGGCCGCAGGGCCTCATGGAAGAGAGAAGCCAGAGCAGAGGTGGTGACAGAAGGAAGCTTCCAGA
AAGAGATGTGTGCCAAGCAATCAGGTGCGCTCAGCCGTGAGGAAGAGGTGGCACCGCTGGCAGGACCATCACTCCCTTCGAGTCCCCATG

>In-frame_ENST00000274695_ENST00000506074_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(amino acids)=526AA_start in transcript=167_stop in transcript=1747
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL

--------------------------------------------------------------
>In-frame_ENST00000378610_ENST00000471646_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(transcript)=2590nt_BP=1309nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGCACTATTCCAGGCATACAGAAAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCT
AGCTGCTTATGGCTATAAAATTACAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGA
CCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGA
CTACCTTAAGGGACTGAGTATCATTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAG
ACTGCTGGGTCAGAAAAAGGATAATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAAT
CATTTCCATCAATACCGGGTGTCTCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGA
ACTAGTAGATAGAGCCAAACAATCTTTTCAAGAGGGTGTTTGTGAGATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATAT
TGGCACCAATCTCCCCACACTCCTGTGGAAACTGGTTGAAGTGATTCCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTA
TATTTTAGAGCATCTGGAGGAAATGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGA
CAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAAC
TATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCC
AAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCAGCACAAGTGAAAAAGCAAAGGAC
AAAAGATCTTTCTCGGGTGTTTCATTCTTACAGTCCATATGATCACAAGATCAATTTCGTATTTCTGTTCAACATCGTCAGGATCCTAAT
GACAAAGTTACGCGCGTCCACCACATCCGAGACAATCCAGTACAGGAAGGCAGTGAAGGCCACCCTGGTGCTCCTGCCCCTCCTGGGCAT
CACCTACATGCTCTTCTTCGTCAATCCCGGGGAGGACGACCTGTCACAGATCATGTTCATCTATTTCAACTCCTTCCTGCAGTCGTTCCA
GGGTTTCTTCGTGTCTGTCTTCTACTGCTTCTTCAATGGAGAGGTGCGCTCAGCCGTGAGGAAGAGGTGGCACCGCTGGCAGGACCATCA
CTCCCTTCGAGTCCCCATGGCCCGGGCCATGTCCATCCCTACATCACCCACACGGATCAGCTTCCACAGCATCAAGCAGACGGCCGCTGT
GTGACCCCTCGGTCGCCCACCTGCACAGCTCCCCTGTCCTCCTCCACCTTCTTCCTCTGGGTTCTCTGTGCTGGGCAGGCTCTCGTGGGG
CAGGAGATGGGAGGGGAGAGACCAGCTCTCCAGCCTGGCAGGAAAGAGGGGGTGCGGCAGCCAAGGGGGACTGCAAGGGACAGGGATGAG
TGGGGGCCACCAGGCTCAGCGCAAGAGGAAGCAGAGGGAATTCACAGGACCCCCTGAGAAGAGCCAGTCAGATGTCTGCAGGCATTTGCC
CATCCCAGCCTCTCTGGCCAGGGCCTTACTGGGCCCAGAGCAGAGAAGGACCTGTCCAACACACACAGCTATTTATAGTAGCAGACACAG
GGCTCCCCTGCCCTACTCATGGAGCCAGCAGCCAGGCAATGGTGTGGCCCTGCACTGGCCCTTGGCCTCCACACTCAGTGGTGCCCCTGC
AGTTGGGTGGGGTACGCCAGCAAAGGATCAGTTTGGCTGCCTTATCCCAGGGGCTGTCACCTAGAGAGGCTCACTTGTACCCCACCCTTG
TTCCTGTGTCCCCTCCCCAGCCATCCTCCCGCCTTGGGGGCTCCATGAAGGATGCAGGCTTCCAGGCCTGGCTTCCTCTCTTGGGAGACC
CCTTCTCTGCCTAGTCCACAGATTAGGCAATCAAGGAAGACGCCATCAGGGAAGCCACATCCTTAGTCAACCAGTTGCATCGTGCGGGGC
AAAATGAGGAGCAGAGGCATGGAGGAGGGAGGCGTGGGATGGGAATAGCAGAAACCAACCATGTCTTCAGTGATTGAAACTCATACCCCA

>In-frame_ENST00000378610_ENST00000471646_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(amino acids)=567AA_start in transcript=10_stop in transcript=1713
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL
RASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLR

--------------------------------------------------------------
>In-frame_ENST00000378610_ENST00000341843_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(transcript)=1927nt_BP=1309nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGCACTATTCCAGGCATACAGAAAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCT
AGCTGCTTATGGCTATAAAATTACAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGA
CCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGA
CTACCTTAAGGGACTGAGTATCATTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAG
ACTGCTGGGTCAGAAAAAGGATAATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAAT
CATTTCCATCAATACCGGGTGTCTCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGA
ACTAGTAGATAGAGCCAAACAATCTTTTCAAGAGGGTGTTTGTGAGATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATAT
TGGCACCAATCTCCCCACACTCCTGTGGAAACTGGTTGAAGTGATTCCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTA
TATTTTAGAGCATCTGGAGGAAATGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGA
CAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAAC
TATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCC
AAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCAGCACAAGTGAAAAAGCAAAGGAC
AAAAGATCTTTCTCGGGTGTTTCATTCTTACAGTCCATATGATCACAAGATCAATTTCGTATTTCTGTTCAACATCGTCAGGATCCTAAT
GACAAAGTTACGCGCGTCCACCACATCCGAGACAATCCAGTACAGGAAGGCAGTGAAGGCCACCCTGGTGCTCCTGCCCCTCCTGGGCAT
CACCTACATGCTCTTCTTCGTCAATCCCGGGGAGGACGACCTGTCACAGATCATGTTCATCTATTTCAACTCCTTCCTGCAGTCGTTCCA
GGGTTTCTTCGTGTCTGTCTTCTACTGCTTCTTCAATGGAGAGGTGCGCTCAGCCGTGAGGAAGAGGTGGCACCGCTGGCAGGACCATCA
CTCCCTTCGAGTCCCCATGGCCCGGGCCATGTCCATCCCTACATCACCCACACGGATCAGCTTCCACAGCATCAAGCAGACGGCCGCTGT
GTGACCCCTCGGTCGCCCACCTGCACAGCTCCCCTGTCCTCCTCCACCTTCTTCCTCTGGGTTCTCTGTGCTGGGCAGGCTCTCGTGGGG
CAGGAGATGGGAGGGGAGAGACCAGCTCTCCAGCCTGGCAGGAAAGAGGGGGTGCGGCAGCCAAGGGGGACTGCAAGGGACAGGGATGAG

>In-frame_ENST00000378610_ENST00000341843_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(amino acids)=567AA_start in transcript=10_stop in transcript=1713
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL
RASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLR

--------------------------------------------------------------
>In-frame_ENST00000378610_ENST00000348438_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(transcript)=1927nt_BP=1309nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGCACTATTCCAGGCATACAGAAAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCT
AGCTGCTTATGGCTATAAAATTACAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGA
CCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGA
CTACCTTAAGGGACTGAGTATCATTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAG
ACTGCTGGGTCAGAAAAAGGATAATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAAT
CATTTCCATCAATACCGGGTGTCTCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGA
ACTAGTAGATAGAGCCAAACAATCTTTTCAAGAGGGTGTTTGTGAGATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATAT
TGGCACCAATCTCCCCACACTCCTGTGGAAACTGGTTGAAGTGATTCCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTA
TATTTTAGAGCATCTGGAGGAAATGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGA
CAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAAC
TATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCC
AAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCAGCACAAGTGAAAAAGCAAAGGAC
AAAAGATCTTTCTCGGGTGTTTCATTCTTACAGTCCATATGATCACAAGATCAATTTCGTATTTCTGTTCAACATCGTCAGGATCCTAAT
GACAAAGTTACGCGCGTCCACCACATCCGAGACAATCCAGTACAGGAAGGCAGTGAAGGCCACCCTGGTGCTCCTGCCCCTCCTGGGCAT
CACCTACATGCTCTTCTTCGTCAATCCCGGGGAGGACGACCTGTCACAGATCATGTTCATCTATTTCAACTCCTTCCTGCAGTCGTTCCA
GGGTTTCTTCGTGTCTGTCTTCTACTGCTTCTTCAATGGAGAGGTGCGCTCAGCCGTGAGGAAGAGGTGGCACCGCTGGCAGGACCATCA
CTCCCTTCGAGTCCCCATGGCCCGGGCCATGTCCATCCCTACATCACCCACACGGATCAGCTTCCACAGCATCAAGCAGACGGCCGCTGT
GTGACCCCTCGGTCGCCCACCTGCACAGCTCCCCTGTCCTCCTCCACCTTCTTCCTCTGGGTTCTCTGTGCTGGGCAGGCTCTCGTGGGG
CAGGAGATGGGAGGGGAGAGACCAGCTCTCCAGCCTGGCAGGAAAGAGGGGGTGCGGCAGCCAAGGGGGACTGCAAGGGACAGGGATGAG

>In-frame_ENST00000378610_ENST00000348438_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(amino acids)=567AA_start in transcript=10_stop in transcript=1713
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL
RASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLR

--------------------------------------------------------------
>In-frame_ENST00000378610_ENST00000506074_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(transcript)=1898nt_BP=1309nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGCACTATTCCAGGCATACAGAAAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCT
AGCTGCTTATGGCTATAAAATTACAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGA
CCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGA
CTACCTTAAGGGACTGAGTATCATTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAG
ACTGCTGGGTCAGAAAAAGGATAATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAAT
CATTTCCATCAATACCGGGTGTCTCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGA
ACTAGTAGATAGAGCCAAACAATCTTTTCAAGAGGGTGTTTGTGAGATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATAT
TGGCACCAATCTCCCCACACTCCTGTGGAAACTGGTTGAAGTGATTCCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTA
TATTTTAGAGCATCTGGAGGAAATGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGA
CAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAAC
TATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCC
AAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCAGCACAAGTGAAAAAGCAAAGGAC
AAAAGATCTTTCTCGGGTGTTTCATTCTTACAGTCCATATGATCACAAGATCAATTTCGTATTTCTGTTCAACATCGTCAGGATCCTAAT
GACAAAGTTACGCGCGTCCACCACATCCGAGACAATCCAGTACAGGAAGGCAGTGAAGGCCACCCTGGTGCTCCTGCCCCTCCTGGGCAT
CACCTACATGCTCTTCTTCGTCAATCCCGGGGAGGACGACCTGTCACAGATCATGTTCATCTATTTCAACTCCTTCCTGCAGTCGTTCCA
GGGTTTCTTCGTGTCTGTCTTCTACTGCTTCTTCAATGGAGAGGGGCTGGAGCCAGTTTAGAAGGTCAACTATGCAGCCCCGAAATAACA
TGCCAGCACCCCACATGTGCACTCAGAGCTGGGTGAGCAAGGAAGCCCAGGCCGCAGGGCCTCATGGAAGAGAGAAGCCAGAGCAGAGGT
GGTGACAGAAGGAAGCTTCCAGAAAGAGATGTGTGCCAAGCAATCAGGTGCGCTCAGCCGTGAGGAAGAGGTGGCACCGCTGGCAGGACC
ATCACTCCCTTCGAGTCCCCATGGCCCGGGCCATGTCCATCCCTACATCACCCACACGGATCAGCTTCCACAGCATCAAGCAGACGGCCG

>In-frame_ENST00000378610_ENST00000506074_TCGA-G3-A7M5-01A_CDKAL1_chr6_21108694_+_CRHR2_chr7_30695628_length(amino acids)=526AA_start in transcript=10_stop in transcript=1590
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVKKQRTKDLSRVFHSYSPYDHKINFVFLFNIVRILMTKL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CDKAL1-CRHR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CDKAL1-CRHR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CDKAL1-CRHR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDKAL1C0011860Diabetes Mellitus, Non-Insulin-Dependent3CTD_human
HgeneCDKAL1C0005910Body Weight2CTD_human
HgeneCDKAL1C0005612Birth Weight1CTD_human
HgeneCDKAL1C0263859Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome1CTD_human
TgeneCRHR2C0011570Mental Depression4PSYGENET
TgeneCRHR2C0011581Depressive disorder4PSYGENET
TgeneCRHR2C0525045Mood Disorders3PSYGENET
TgeneCRHR2C0003123Anorexia1CTD_human
TgeneCRHR2C0003469Anxiety Disorders1CTD_human
TgeneCRHR2C0005586Bipolar Disorder1PSYGENET
TgeneCRHR2C0009171Cocaine Abuse1CTD_human
TgeneCRHR2C0020538Hypertensive disease1CTD_human
TgeneCRHR2C0021368Inflammation1CTD_human
TgeneCRHR2C0024115Lung diseases1CTD_human
TgeneCRHR2C0178417Anhedonia1PSYGENET
TgeneCRHR2C0233477Dysphoric mood1PSYGENET
TgeneCRHR2C0236736Cocaine-Related Disorders1CTD_human
TgeneCRHR2C0376280Anxiety States, Neurotic1CTD_human
TgeneCRHR2C0600427Cocaine Dependence1CTD_human
TgeneCRHR2C1279420Anxiety neurosis (finding)1CTD_human