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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDKAL1-GMDS (FusionGDB2 ID:15368)

Fusion Gene Summary for CDKAL1-GMDS

check button Fusion gene summary
Fusion gene informationFusion gene name: CDKAL1-GMDS
Fusion gene ID: 15368
HgeneTgene
Gene symbol

CDKAL1

GMDS

Gene ID

54901

2762

Gene nameCDK5 regulatory subunit associated protein 1 like 1GDP-mannose 4,6-dehydratase
Synonyms-GMD|SDR3E1
Cytomap

6p22.3

6p25.3

Type of geneprotein-codingprotein-coding
Descriptionthreonylcarbamoyladenosine tRNA methylthiotransferasetRNA-t(6)A37 methylthiotransferaseGDP-mannose 4,6 dehydrataseGDP-D-mannose dehydrataseshort chain dehydrogenase/reductase family 3E, member 1
Modification date2020032220200313
UniProtAcc.

O60547

Ensembl transtripts involved in fusion geneENST00000274695, ENST00000378624, 
ENST00000378610, ENST00000476517, 
ENST00000530927, ENST00000380815, 
ENST00000467288, 
Fusion gene scores* DoF score37 X 20 X 14=1036014 X 10 X 8=1120
# samples 3915
** MAII scorelog2(39/10360*10)=-4.73140606882431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1120*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDKAL1 [Title/Abstract] AND GMDS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDKAL1(20548936)-GMDS(1961200), # samples:1
CDKAL1(21065459)-GMDS(1961200), # samples:1
Anticipated loss of major functional domain due to fusion event.CDKAL1-GMDS seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CDKAL1-GMDS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGMDS

GO:0019673

GDP-mannose metabolic process

9525924

TgeneGMDS

GO:0042351

'de novo' GDP-L-fucose biosynthetic process

9525924


check buttonFusion gene breakpoints across CDKAL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GMDS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1331CDKAL1chr6

20548936

+GMDSchr6

1961200

-
ChimerDB4STADTCGA-HU-A4GNCDKAL1chr6

21065459

+GMDSchr6

1961200

-


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Fusion Gene ORF analysis for CDKAL1-GMDS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000274695ENST00000530927CDKAL1chr6

20548936

+GMDSchr6

1961200

-
Frame-shiftENST00000274695ENST00000380815CDKAL1chr6

20548936

+GMDSchr6

1961200

-
5CDS-intronENST00000274695ENST00000467288CDKAL1chr6

20548936

+GMDSchr6

1961200

-
intron-3CDSENST00000378624ENST00000530927CDKAL1chr6

20548936

+GMDSchr6

1961200

-
intron-3CDSENST00000378624ENST00000380815CDKAL1chr6

20548936

+GMDSchr6

1961200

-
intron-intronENST00000378624ENST00000467288CDKAL1chr6

20548936

+GMDSchr6

1961200

-
Frame-shiftENST00000378610ENST00000530927CDKAL1chr6

20548936

+GMDSchr6

1961200

-
Frame-shiftENST00000378610ENST00000380815CDKAL1chr6

20548936

+GMDSchr6

1961200

-
5CDS-intronENST00000378610ENST00000467288CDKAL1chr6

20548936

+GMDSchr6

1961200

-
intron-3CDSENST00000476517ENST00000530927CDKAL1chr6

20548936

+GMDSchr6

1961200

-
intron-3CDSENST00000476517ENST00000380815CDKAL1chr6

20548936

+GMDSchr6

1961200

-
intron-intronENST00000476517ENST00000467288CDKAL1chr6

20548936

+GMDSchr6

1961200

-
In-frameENST00000274695ENST00000530927CDKAL1chr6

21065459

+GMDSchr6

1961200

-
In-frameENST00000274695ENST00000380815CDKAL1chr6

21065459

+GMDSchr6

1961200

-
5CDS-intronENST00000274695ENST00000467288CDKAL1chr6

21065459

+GMDSchr6

1961200

-
In-frameENST00000378624ENST00000530927CDKAL1chr6

21065459

+GMDSchr6

1961200

-
In-frameENST00000378624ENST00000380815CDKAL1chr6

21065459

+GMDSchr6

1961200

-
5CDS-intronENST00000378624ENST00000467288CDKAL1chr6

21065459

+GMDSchr6

1961200

-
In-frameENST00000378610ENST00000530927CDKAL1chr6

21065459

+GMDSchr6

1961200

-
In-frameENST00000378610ENST00000380815CDKAL1chr6

21065459

+GMDSchr6

1961200

-
5CDS-intronENST00000378610ENST00000467288CDKAL1chr6

21065459

+GMDSchr6

1961200

-
intron-3CDSENST00000476517ENST00000530927CDKAL1chr6

21065459

+GMDSchr6

1961200

-
intron-3CDSENST00000476517ENST00000380815CDKAL1chr6

21065459

+GMDSchr6

1961200

-
intron-intronENST00000476517ENST00000467288CDKAL1chr6

21065459

+GMDSchr6

1961200

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000274695CDKAL1chr621065459+ENST00000530927GMDSchr61961200-254014031672176669
ENST00000274695CDKAL1chr621065459+ENST00000380815GMDSchr61961200-254014031672176669
ENST00000378624CDKAL1chr621065459+ENST00000530927GMDSchr61961200-242712902642063599
ENST00000378624CDKAL1chr621065459+ENST00000380815GMDSchr61961200-242712902642063599
ENST00000378610CDKAL1chr621065459+ENST00000530927GMDSchr61961200-23831246102019669
ENST00000378610CDKAL1chr621065459+ENST00000380815GMDSchr61961200-23831246102019669

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000274695ENST00000530927CDKAL1chr621065459+GMDSchr61961200-0.0008119890.999188
ENST00000274695ENST00000380815CDKAL1chr621065459+GMDSchr61961200-0.0008119890.999188
ENST00000378624ENST00000530927CDKAL1chr621065459+GMDSchr61961200-0.0009223780.99907756
ENST00000378624ENST00000380815CDKAL1chr621065459+GMDSchr61961200-0.0009223780.99907756
ENST00000378610ENST00000530927CDKAL1chr621065459+GMDSchr61961200-0.0010396620.9989604
ENST00000378610ENST00000380815CDKAL1chr621065459+GMDSchr61961200-0.0010396620.9989604

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Fusion Genomic Features for CDKAL1-GMDS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDKAL1-GMDS


check button Go to

FGviewer for the breakpoints of chr6:21065459-chr6:1961200

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GMDS

O60547

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose. {ECO:0000269|PubMed:9525924}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKAL1chr6:21065459chr6:1961200ENST00000274695+121664_172412.0580.0DomainMTTase N-terminal
HgeneCDKAL1chr6:21065459chr6:1961200ENST00000378610+101464_172412.0580.0DomainMTTase N-terminal
HgeneCDKAL1chr6:21065459chr6:1961200ENST00000378624+111464_172342.0489.0DomainMTTase N-terminal
TgeneGMDSchr6:21065459chr6:1961200ENST00000530927311108_11285.0343.0Nucleotide bindingNADP
TgeneGMDSchr6:21065459chr6:1961200ENST0000053092731186_8785.0343.0Nucleotide bindingNADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKAL1chr6:21065459chr6:1961200ENST00000274695+1216200_431412.0580.0DomainRadical SAM core
HgeneCDKAL1chr6:21065459chr6:1961200ENST00000274695+1216431_493412.0580.0DomainTRAM
HgeneCDKAL1chr6:21065459chr6:1961200ENST00000378610+1014200_431412.0580.0DomainRadical SAM core
HgeneCDKAL1chr6:21065459chr6:1961200ENST00000378610+1014431_493412.0580.0DomainTRAM
HgeneCDKAL1chr6:21065459chr6:1961200ENST00000378624+1114200_431342.0489.0DomainRadical SAM core
HgeneCDKAL1chr6:21065459chr6:1961200ENST00000378624+1114431_493342.0489.0DomainTRAM
HgeneCDKAL1chr6:21065459chr6:1961200ENST00000274695+1216556_578412.0580.0TransmembraneHelical
HgeneCDKAL1chr6:21065459chr6:1961200ENST00000378610+1014556_578412.0580.0TransmembraneHelical
HgeneCDKAL1chr6:21065459chr6:1961200ENST00000378624+1114556_578342.0489.0TransmembraneHelical
TgeneGMDSchr6:21065459chr6:1961200ENST00000380815311108_112115.0373.0Nucleotide bindingNADP
TgeneGMDSchr6:21065459chr6:1961200ENST0000038081531130_35115.0373.0Nucleotide bindingNADP
TgeneGMDSchr6:21065459chr6:1961200ENST0000038081531155_58115.0373.0Nucleotide bindingNADP
TgeneGMDSchr6:21065459chr6:1961200ENST0000038081531186_87115.0373.0Nucleotide bindingNADP
TgeneGMDSchr6:21065459chr6:1961200ENST0000053092731130_3585.0343.0Nucleotide bindingNADP
TgeneGMDSchr6:21065459chr6:1961200ENST0000053092731155_5885.0343.0Nucleotide bindingNADP


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Fusion Gene Sequence for CDKAL1-GMDS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000274695_ENST00000530927_TCGA-HU-A4GN_CDKAL1_chr6_21065459_+_GMDS_chr6_1961200_length(transcript)=2540nt_BP=1403nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGCACTATTCCAGGCATACAGA
AAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCTAGCTGCTTATGGCTATAAAATTA
CAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAA
AAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCA
TTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAGACTGCTGGGTCAGAAAAAGGATA
ATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAATCATTTCCATCAATACCGGGTGTC
TCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGAACTAGTAGATAGAGCCAAACAAT
CTTTTCAAGAGGGTGTTTGTGAGATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATATTGGCACCAATCTCCCCACACTCC
TGTGGAAACTGGTTGAAGTGATTCCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTATATTTTAGAGCATCTGGAGGAAA
TGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAA
GAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTG
GTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTT
ACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCAGCACAAGTGATTTCCTTTGACCTCGCTGAGTACACTGCGGACGTTG
ACGGAGTTGGCACTCTACGACTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAAC
TTTATGGGAAAGTGCAGGAAATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGGGCAGCAAAACTCTATGCCTATT
GGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAGAGTCCCAGAAGAGGAGCTAATT
TCGTTACTCGAAAAATTAGCCGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTGGGAAATCTGGATGCCAAACGAG
ATTGGGGCCATGCCAAGGACTATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGG
TCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCA
GATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCA
AAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGA
CAAACCCCAATGCCTGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTACAATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGG
ATGGGGAGCGGCGTGCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCTGCGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAG
GTTTGTAGCAGCCGGGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTTGTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATG
TTTTAATCACATTCACTTTACTTGAAATTATGTTGTTACACAACAAATTGTGGGGCCTTCAAATTGTTTTTCTCTTTTCATATTAAAAAT

>In-frame_ENST00000274695_ENST00000530927_TCGA-HU-A4GN_CDKAL1_chr6_21065459_+_GMDS_chr6_1961200_length(amino acids)=669AA_start in transcript=167_stop in transcript=2176
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQA
STSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNL
DAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQ

--------------------------------------------------------------
>In-frame_ENST00000274695_ENST00000380815_TCGA-HU-A4GN_CDKAL1_chr6_21065459_+_GMDS_chr6_1961200_length(transcript)=2540nt_BP=1403nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGCACTATTCCAGGCATACAGA
AAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCTAGCTGCTTATGGCTATAAAATTA
CAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAA
AAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCA
TTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAGACTGCTGGGTCAGAAAAAGGATA
ATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAATCATTTCCATCAATACCGGGTGTC
TCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGAACTAGTAGATAGAGCCAAACAAT
CTTTTCAAGAGGGTGTTTGTGAGATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATATTGGCACCAATCTCCCCACACTCC
TGTGGAAACTGGTTGAAGTGATTCCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTATATTTTAGAGCATCTGGAGGAAA
TGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAA
GAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTG
GTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTT
ACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCAGCACAAGTGATTTCCTTTGACCTCGCTGAGTACACTGCGGACGTTG
ACGGAGTTGGCACTCTACGACTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAAC
TTTATGGGAAAGTGCAGGAAATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGGGCAGCAAAACTCTATGCCTATT
GGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAGAGTCCCAGAAGAGGAGCTAATT
TCGTTACTCGAAAAATTAGCCGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTGGGAAATCTGGATGCCAAACGAG
ATTGGGGCCATGCCAAGGACTATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGG
TCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCA
GATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCA
AAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGA
CAAACCCCAATGCCTGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTACAATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGG
ATGGGGAGCGGCGTGCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCTGCGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAG
GTTTGTAGCAGCCGGGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTTGTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATG
TTTTAATCACATTCACTTTACTTGAAATTATGTTGTTACACAACAAATTGTGGGGCCTTCAAATTGTTTTTCTCTTTTCATATTAAAAAT

>In-frame_ENST00000274695_ENST00000380815_TCGA-HU-A4GN_CDKAL1_chr6_21065459_+_GMDS_chr6_1961200_length(amino acids)=669AA_start in transcript=167_stop in transcript=2176
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQA
STSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNL
DAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQ

--------------------------------------------------------------
>In-frame_ENST00000378624_ENST00000530927_TCGA-HU-A4GN_CDKAL1_chr6_21065459_+_GMDS_chr6_1961200_length(transcript)=2427nt_BP=1290nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGAAAATGCATCCGATGCAGAT
TTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAA
ATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCATTGGGGTTCAGCAGATAGATCGT
GTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAGACTGCTGGGTCAGAAAAAGGATAATGGAAGGCGGCTTGGGGGAGCA
CGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAATCATTTCCATCAATACCGGGTGTCTCAATGCTTGTACCTACTGCAAA
ACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGAACTAGTAGATAGAGCCAAACAATCTTTTCAAGAGGGTGTTTGTGAG
ATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATATTGGCACCAATCTCCCCACACTCCTGTGGAAACTGGTTGAAGTGATT
CCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTATATTTTAGAGCATCTGGAGGAAATGGCAAAAATCCTTAATCACCCC
AGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTC
AAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAG
GATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCT
GCAAAAATGGAACAAGTTCCAGCACAAGTGATTTCCTTTGACCTCGCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGACTT
CTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAAATA
CCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGGGCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGTGAG
GCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAGAGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGCCGG
TCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTGGGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGACTAT
GTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTC
GAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTT
CACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGG
AAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGCG
CCTCGGAGCCCGGCCCGCCCTCCGGCTACAATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCTG
CGGGTCCCCTGCGGCCCCTGCTGCCGCTGCGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGAC
CCTCCAGGGTTTGGGTCGCTTTGCGTTTGTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACTT

>In-frame_ENST00000378624_ENST00000530927_TCGA-HU-A4GN_CDKAL1_chr6_21065459_+_GMDS_chr6_1961200_length(amino acids)=599AA_start in transcript=264_stop in transcript=2063
MLSRRYEGEIPKNICKRKKTVHQVTENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQI
DRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGV
CEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVA
DFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVISFDLAEYTADVDGVGTL
RLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKI
SRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETG

--------------------------------------------------------------
>In-frame_ENST00000378624_ENST00000380815_TCGA-HU-A4GN_CDKAL1_chr6_21065459_+_GMDS_chr6_1961200_length(transcript)=2427nt_BP=1290nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGAAAATGCATCCGATGCAGAT
TTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGACCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAA
ATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGACTACCTTAAGGGACTGAGTATCATTGGGGTTCAGCAGATAGATCGT
GTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAGACTGCTGGGTCAGAAAAAGGATAATGGAAGGCGGCTTGGGGGAGCA
CGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAATCATTTCCATCAATACCGGGTGTCTCAATGCTTGTACCTACTGCAAA
ACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGAACTAGTAGATAGAGCCAAACAATCTTTTCAAGAGGGTGTTTGTGAG
ATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATATTGGCACCAATCTCCCCACACTCCTGTGGAAACTGGTTGAAGTGATT
CCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTATATTTTAGAGCATCTGGAGGAAATGGCAAAAATCCTTAATCACCCC
AGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGACAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTC
AAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAACTATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAG
GATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCCAAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCT
GCAAAAATGGAACAAGTTCCAGCACAAGTGATTTCCTTTGACCTCGCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGACTT
CTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTTCTACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAAATA
CCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGGGGCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGTGAG
GCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGAGAGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGCCGG
TCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTTGGGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGACTAT
GTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGACTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTC
GAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGGAAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTT
CACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGACTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGG
AAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCACGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGCG
CCTCGGAGCCCGGCCCGCCCTCCGGCTACAATCCCCGCAGAGTCTCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCTG
CGGGTCCCCTGCGGCCCCTGCTGCCGCTGCGCTGTCCCGGCCGCAAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGAC
CCTCCAGGGTTTGGGTCGCTTTGCGTTTGTCGAAGCCTCCTCTGAATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACTT

>In-frame_ENST00000378624_ENST00000380815_TCGA-HU-A4GN_CDKAL1_chr6_21065459_+_GMDS_chr6_1961200_length(amino acids)=599AA_start in transcript=264_stop in transcript=2063
MLSRRYEGEIPKNICKRKKTVHQVTENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQI
DRVVEVVEETIKGHSVRLLGQKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGV
CEIWLTSEDTGAYGRDIGTNLPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVA
DFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVISFDLAEYTADVDGVGTL
RLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKI
SRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETG

--------------------------------------------------------------
>In-frame_ENST00000378610_ENST00000530927_TCGA-HU-A4GN_CDKAL1_chr6_21065459_+_GMDS_chr6_1961200_length(transcript)=2383nt_BP=1246nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGCACTATTCCAGGCATACAGAAAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCT
AGCTGCTTATGGCTATAAAATTACAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGA
CCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGA
CTACCTTAAGGGACTGAGTATCATTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAG
ACTGCTGGGTCAGAAAAAGGATAATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAAT
CATTTCCATCAATACCGGGTGTCTCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGA
ACTAGTAGATAGAGCCAAACAATCTTTTCAAGAGGGTGTTTGTGAGATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATAT
TGGCACCAATCTCCCCACACTCCTGTGGAAACTGGTTGAAGTGATTCCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTA
TATTTTAGAGCATCTGGAGGAAATGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGA
CAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAAC
TATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCC
AAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCAGCACAAGTGATTTCCTTTGACCT
CGCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGACTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTT
CTACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAAATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGG
GGCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGA
GAGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGCCGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTT
GGGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGACTATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGA
CTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGG
AAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGA
CTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCA
CGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTACAATCCCCGCAGAGTC
TCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCTGCGCTGTCCCGGCCGC
AAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTTGTCGAAGCCTCCTCTG
AATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACTTGAAATTATGTTGTTACACAACAAATTGTGGGGCCTTCAAATTGT

>In-frame_ENST00000378610_ENST00000530927_TCGA-HU-A4GN_CDKAL1_chr6_21065459_+_GMDS_chr6_1961200_length(amino acids)=669AA_start in transcript=10_stop in transcript=2019
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQA
STSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNL
DAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQ

--------------------------------------------------------------
>In-frame_ENST00000378610_ENST00000380815_TCGA-HU-A4GN_CDKAL1_chr6_21065459_+_GMDS_chr6_1961200_length(transcript)=2383nt_BP=1246nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGCACTATTCCAGGCATACAGAAAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCT
AGCTGCTTATGGCTATAAAATTACAGAAAATGCATCCGATGCAGATTTATGGCTCCTGAACAGTTGCACTGTAAAAAACCCAGCTGAAGA
CCACTTTAGAAACTCAATTAAAAAAGCTCAAGAGGAGAACAAGAAAATCGTACTGGCTGGATGCGTTCCTCAAGCCCAGCCTCGCCAGGA
CTACCTTAAGGGACTGAGTATCATTGGGGTTCAGCAGATAGATCGTGTGGTAGAAGTTGTGGAGGAGACAATTAAAGGTCACTCTGTGAG
ACTGCTGGGTCAGAAAAAGGATAATGGAAGGCGGCTTGGGGGAGCACGATTGGATTTGCCGAAGATTAGGAAGAATCCACTGATAGAAAT
CATTTCCATCAATACCGGGTGTCTCAATGCTTGTACCTACTGCAAAACTAAACACGCCAGAGGAAATTTGGCCAGTTATCCAATTGATGA
ACTAGTAGATAGAGCCAAACAATCTTTTCAAGAGGGTGTTTGTGAGATATGGTTGACCAGTGAAGACACGGGGGCTTATGGCAGAGATAT
TGGCACCAATCTCCCCACACTCCTGTGGAAACTGGTTGAAGTGATTCCTGAGGGAGCAATGCTGAGGCTTGGCATGACAAATCCGCCCTA
TATTTTAGAGCATCTGGAGGAAATGGCAAAAATCCTTAATCACCCCAGAGTCTACGCTTTTCTGCACATACCAGTCCAGTCTGCCTCCGA
CAGCGTACTCATGGAAATGAAAAGAGAATACTGTGTGGCTGACTTCAAAAGAGTAGTGGATTTTCTGAAAGAGAAAGTTCCTGGAATAAC
TATTGCTACAGATATTATCTGTGGTTTTCCTGGAGAAACAGATCAGGATTTTCAAGAAACAGTGAAACTTGTTGAAGAGTACAAATTCCC
AAGCCTGTTTATTAACCAATTTTACCCAAGACCAGGAACTCCTGCTGCAAAAATGGAACAAGTTCCAGCACAAGTGATTTCCTTTGACCT
CGCTGAGTACACTGCGGACGTTGACGGAGTTGGCACTCTACGACTTCTAGATGCAGTTAAGACTTGTGGCCTTATCAACTCTGTGAAGTT
CTACCAAGCCTCAACAAGTGAACTTTATGGGAAAGTGCAGGAAATACCCCAGAAGGAGACCACCCCTTTCTATCCCCGGTCACCCTATGG
GGCAGCAAAACTCTATGCCTATTGGATTGTGGTGAACTTCCGTGAGGCGTATAATCTCTTTGCAGTGAACGGCATTCTCTTCAATCATGA
GAGTCCCAGAAGAGGAGCTAATTTCGTTACTCGAAAAATTAGCCGGTCAGTAGCTAAGATTTACCTTGGACAACTGGAATGTTTCAGTTT
GGGAAATCTGGATGCCAAACGAGATTGGGGCCATGCCAAGGACTATGTGGAGGCTATGTGGTTGATGTTGCAGAATGATGAGCCGGAGGA
CTTCGTTATAGCTACTGGGGAGGTCCATAGTGTCCGGGAATTTGTCGAGAAATCATTCTTGCACATTGGAAAAACCATTGTGTGGGAAGG
AAAGAATGAAAATGAAGTGGGCAGATGTAAAGAGACCGGCAAAGTTCACGTGACTGTGGATCTCAAGTACTACCGGCCAACTGAAGTGGA
CTTTCTGCAGGGCGACTGCACCAAAGCGAAACAGAAGCTGAACTGGAAGCCCCGGGTCGCTTTCGATGAGCTGGTGAGGGAGATGGTGCA
CGCCGACGTGGAGCTCATGAGGACAAACCCCAATGCCTGAGCAGCGCCTCGGAGCCCGGCCCGCCCTCCGGCTACAATCCCCGCAGAGTC
TCCGGTGCAGACGCGCTGCGGGGATGGGGAGCGGCGTGCCAATCTGCGGGTCCCCTGCGGCCCCTGCTGCCGCTGCGCTGTCCCGGCCGC
AAGAGCGGGGCCGCCCCGCCGAGGTTTGTAGCAGCCGGGATGTGACCCTCCAGGGTTTGGGTCGCTTTGCGTTTGTCGAAGCCTCCTCTG
AATGGCTTTGTGAAATCAAGATGTTTTAATCACATTCACTTTACTTGAAATTATGTTGTTACACAACAAATTGTGGGGCCTTCAAATTGT

>In-frame_ENST00000378610_ENST00000380815_TCGA-HU-A4GN_CDKAL1_chr6_21065459_+_GMDS_chr6_1961200_length(amino acids)=669AA_start in transcript=10_stop in transcript=2019
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENKKIVLAGCVPQAQPRQDYLKGLSIIGVQQIDRVVEVVEETIKGHSVRLLG
QKKDNGRRLGGARLDLPKIRKNPLIEIISINTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDIGTN
LPTLLWKLVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIAT
DIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKMEQVPAQVISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQA
STSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNL
DAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDKAL1-GMDS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDKAL1-GMDS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDKAL1-GMDS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDKAL1C0011860Diabetes Mellitus, Non-Insulin-Dependent3CTD_human
HgeneCDKAL1C0005910Body Weight2CTD_human
HgeneCDKAL1C0005612Birth Weight1CTD_human
HgeneCDKAL1C0263859Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome1CTD_human