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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDKAL1-JARID2 (FusionGDB2 ID:15373)

Fusion Gene Summary for CDKAL1-JARID2

check button Fusion gene summary
Fusion gene informationFusion gene name: CDKAL1-JARID2
Fusion gene ID: 15373
HgeneTgene
Gene symbol

CDKAL1

JARID2

Gene ID

54901

3720

Gene nameCDK5 regulatory subunit associated protein 1 like 1jumonji and AT-rich interaction domain containing 2
Synonyms-JMJ
Cytomap

6p22.3

6p22.3

Type of geneprotein-codingprotein-coding
Descriptionthreonylcarbamoyladenosine tRNA methylthiotransferasetRNA-t(6)A37 methylthiotransferaseprotein Jumonjijumonji homologjumonji, AT rich interactive domain 2jumonji-like proteinjumonji/ARID domain-containing protein 2
Modification date2020032220200313
UniProtAcc.

Q92833

Ensembl transtripts involved in fusion geneENST00000274695, ENST00000378624, 
ENST00000378610, ENST00000476517, 
ENST00000341776, ENST00000397311, 
ENST00000541660, ENST00000474854, 
Fusion gene scores* DoF score37 X 20 X 14=103606 X 6 X 3=108
# samples 396
** MAII scorelog2(39/10360*10)=-4.73140606882431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDKAL1 [Title/Abstract] AND JARID2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointJARID2(15410596)-CDKAL1(20649524), # samples:3
CDKAL1(20548936)-JARID2(15487538), # samples:1
Anticipated loss of major functional domain due to fusion event.JARID2-CDKAL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
JARID2-CDKAL1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CDKAL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across JARID2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A48N-01ACDKAL1chr6

20548936

-JARID2chr6

15487538

+


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Fusion Gene ORF analysis for CDKAL1-JARID2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000274695ENST00000341776CDKAL1chr6

20548936

-JARID2chr6

15487538

+
In-frameENST00000274695ENST00000397311CDKAL1chr6

20548936

-JARID2chr6

15487538

+
In-frameENST00000274695ENST00000541660CDKAL1chr6

20548936

-JARID2chr6

15487538

+
5CDS-intronENST00000274695ENST00000474854CDKAL1chr6

20548936

-JARID2chr6

15487538

+
intron-3CDSENST00000378624ENST00000341776CDKAL1chr6

20548936

-JARID2chr6

15487538

+
intron-3CDSENST00000378624ENST00000397311CDKAL1chr6

20548936

-JARID2chr6

15487538

+
intron-3CDSENST00000378624ENST00000541660CDKAL1chr6

20548936

-JARID2chr6

15487538

+
intron-intronENST00000378624ENST00000474854CDKAL1chr6

20548936

-JARID2chr6

15487538

+
In-frameENST00000378610ENST00000341776CDKAL1chr6

20548936

-JARID2chr6

15487538

+
In-frameENST00000378610ENST00000397311CDKAL1chr6

20548936

-JARID2chr6

15487538

+
In-frameENST00000378610ENST00000541660CDKAL1chr6

20548936

-JARID2chr6

15487538

+
5CDS-intronENST00000378610ENST00000474854CDKAL1chr6

20548936

-JARID2chr6

15487538

+
intron-3CDSENST00000476517ENST00000341776CDKAL1chr6

20548936

-JARID2chr6

15487538

+
intron-3CDSENST00000476517ENST00000397311CDKAL1chr6

20548936

-JARID2chr6

15487538

+
intron-3CDSENST00000476517ENST00000541660CDKAL1chr6

20548936

-JARID2chr6

15487538

+
intron-intronENST00000476517ENST00000474854CDKAL1chr6

20548936

-JARID2chr6

15487538

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000274695CDKAL1chr620548936-ENST00000341776JARID2chr615487538+529445316735231118
ENST00000274695CDKAL1chr620548936-ENST00000397311JARID2chr615487538+363945316735231118
ENST00000274695CDKAL1chr620548936-ENST00000541660JARID2chr615487538+30204531672779870
ENST00000378610CDKAL1chr620548936-ENST00000341776JARID2chr615487538+51372961033661118
ENST00000378610CDKAL1chr620548936-ENST00000397311JARID2chr615487538+34822961033661118
ENST00000378610CDKAL1chr620548936-ENST00000541660JARID2chr615487538+2863296102622870

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000274695ENST00000341776CDKAL1chr620548936-JARID2chr615487538+0.0007754050.99922454
ENST00000274695ENST00000397311CDKAL1chr620548936-JARID2chr615487538+0.0037586550.99624133
ENST00000274695ENST00000541660CDKAL1chr620548936-JARID2chr615487538+0.0037113480.99628866
ENST00000378610ENST00000341776CDKAL1chr620548936-JARID2chr615487538+0.0007346830.9992654
ENST00000378610ENST00000397311CDKAL1chr620548936-JARID2chr615487538+0.0040779310.9959221
ENST00000378610ENST00000541660CDKAL1chr620548936-JARID2chr615487538+0.0049009620.995099

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Fusion Genomic Features for CDKAL1-JARID2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDKAL1-JARID2


check button Go to

FGviewer for the breakpoints of chr6:20548936-chr6:15487538

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.JARID2

Q92833

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20075857, PubMed:29499137, PubMed:31959557). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (By similarity). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (By similarity). Participates in the negative regulation of cell proliferation signaling (By similarity). Does not have histone demethylase activity (By similarity). {ECO:0000250|UniProtKB:Q62315, ECO:0000269|PubMed:20075857, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneJARID2chr6:20548936chr6:15487538ENST000003417764181234_1246223.333333333333341247.0Compositional biasNote=Poly-Ser
TgeneJARID2chr6:20548936chr6:15487538ENST000003973114181234_124651.3333333333333361075.0Compositional biasNote=Poly-Ser
TgeneJARID2chr6:20548936chr6:15487538ENST00000341776418557_598223.333333333333341247.0DomainJmjN
TgeneJARID2chr6:20548936chr6:15487538ENST00000341776418621_713223.333333333333341247.0DomainARID
TgeneJARID2chr6:20548936chr6:15487538ENST00000341776418884_1048223.333333333333341247.0DomainJmjC
TgeneJARID2chr6:20548936chr6:15487538ENST00000397311418557_59851.3333333333333361075.0DomainJmjN
TgeneJARID2chr6:20548936chr6:15487538ENST00000397311418621_71351.3333333333333361075.0DomainARID
TgeneJARID2chr6:20548936chr6:15487538ENST00000397311418884_104851.3333333333333361075.0DomainJmjC
TgeneJARID2chr6:20548936chr6:15487538ENST00000341776418874_878223.333333333333341247.0MotifNote=GSGFP motif
TgeneJARID2chr6:20548936chr6:15487538ENST00000397311418104_11051.3333333333333361075.0MotifNuclear localization signal
TgeneJARID2chr6:20548936chr6:15487538ENST00000397311418874_87851.3333333333333361075.0MotifNote=GSGFP motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKAL1chr6:20548936chr6:15487538ENST00000274695-416200_43195.33333333333333580.0DomainRadical SAM core
HgeneCDKAL1chr6:20548936chr6:15487538ENST00000274695-416431_49395.33333333333333580.0DomainTRAM
HgeneCDKAL1chr6:20548936chr6:15487538ENST00000274695-41664_17295.33333333333333580.0DomainMTTase N-terminal
HgeneCDKAL1chr6:20548936chr6:15487538ENST00000378610-214200_43195.33333333333333580.0DomainRadical SAM core
HgeneCDKAL1chr6:20548936chr6:15487538ENST00000378610-214431_49395.33333333333333580.0DomainTRAM
HgeneCDKAL1chr6:20548936chr6:15487538ENST00000378610-21464_17295.33333333333333580.0DomainMTTase N-terminal
HgeneCDKAL1chr6:20548936chr6:15487538ENST00000378624-114200_4310489.0DomainRadical SAM core
HgeneCDKAL1chr6:20548936chr6:15487538ENST00000378624-114431_4930489.0DomainTRAM
HgeneCDKAL1chr6:20548936chr6:15487538ENST00000378624-11464_1720489.0DomainMTTase N-terminal
HgeneCDKAL1chr6:20548936chr6:15487538ENST00000274695-416556_57895.33333333333333580.0TransmembraneHelical
HgeneCDKAL1chr6:20548936chr6:15487538ENST00000378610-214556_57895.33333333333333580.0TransmembraneHelical
HgeneCDKAL1chr6:20548936chr6:15487538ENST00000378624-114556_5780489.0TransmembraneHelical
TgeneJARID2chr6:20548936chr6:15487538ENST00000341776418104_110223.333333333333341247.0MotifNuclear localization signal


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Fusion Gene Sequence for CDKAL1-JARID2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000274695_ENST00000341776_TCGA-DX-A48N-01A_CDKAL1_chr6_20548936_-_JARID2_chr6_15487538_length(transcript)=5294nt_BP=453nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGCACTATTCCAGGCATACAGA
AAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCTAGCTGCTTATGGCTATAAAATTA
CAGTTTTCAATGGTTCCAGCAGGTCAACACGGGAGAAGGAACCTGTTCAAAAACACAAAAGCAAAGAGGCCACTCCCGCAAAGGAGAAGC
ACAGCGATCACCGGGCTGACAGCCGCCGGGAGCAGGCTTCAGCTAACCACCCCGCAGCGGCCCCCTCCACGGGTTCCTCGGCCAAGGGGC
TTGCTGCCACCCATCACCACCCCCCTCTGCATCGGTCGGCTCAGGACTTACGGAAACAGGTTTCTAAGGTAAACGGAGTCACTCGAATGT
CATCTCTGGGTGCAGGTGTAACCAGTGCCAAAAAGATGCGCGAGGTCAGACCTTCACCATCCAAAACTGTGAAGTACACTGCCACGGTGA
CGAAGGGGGCTGTCACATACACCAAAGCCAAGAGAGAACTGGTCAAGGACACCAAACCCAATCACCACAAGCCCAGTTCCGCTGTCAACC
ACACAATCTCAGGGAAAACTGAAAGTAGCAATGCAAAAACCCGCAAACAGGTGCTATCCCTCGGGGGGGCGTCCAAGTCCACTGGGCCCG
CCGTCAATGGCCTCAAGGTCAGTGGCAGGTTGAACCCAAAGTCATGCACTAAGGAGGTGGGGGGGCGGCAGCTGCGGGAGGGCCTGCAGC
TGCGGGAGGGGCTGCGGAACTCCAAGAGGAGACTGGAAGAGGCACACCAGGCGGAGAAGCCGCAGTCGCCCCCCAAGAAGATGAAAGGGG
CGGCTGGCCCCGCCGAAGGCCCTGGCAAGAAGGCCCCGGCCGAGAGAGGTCTGCTGAACGGACACGTGAAGAAGGAAGTGCCGGAGCGCA
GTCTGGAGAGGAATCGGCCGAAGCGGGCCACGGCCGGGAAGAGCACGCCAGGCAGACAAGCACATGGCAAGGCGGACAGCGCCTCCTGTG
AAAATCGTTCTACCTCGCAACCGGAGTCCGTGCACAAGCCGCAGGACTCGGGCAAGGCCGAGAAGGGCGGCGGCAAGGCCGGGTGGGCGG
CCATGGACGAGATCCCCGTCCTCAGGCCCTCCGCCAAGGAGTTCCACGATCCGCTCATCTACATCGAGTCGGTCCGCGCTCAGGTGGAGA
AGTTCGGGATGTGCAGGGTGATCCCCCCTCCGGACTGGCGGCCCGAGTGCAAGCTCAACGATGAGATGCGGTTTGTCACGCAGATTCAGC
ACATCCACAAGCTGGGCCGGCGCTGGGGCCCCAACGTGCAGCGGCTGGCCTGCATCAAGAAGCACCTCAAATCTCAGGGCATCACCATGG
ACGAGCTCCCGCTCATAGGGGGCTGTGAGCTCGACCTGGCCTGCTTTTTCCGGCTGATTAATGAGATGGGCGGCATGCAGCAAGTGACTG
ACCTCAAAAAATGGAACAAACTAGCAGACATGCTGCGCATCCCCAGAACTGCCCAGGACCGGCTGGCCAAGCTGCAGGAGGCCTACTGCC
AGTACCTACTCTCCTACGACTCCCTGTCCCCAGAGGAGCACCGGCGGCTGGAGAAGGAGGTGCTGATGGAGAAGGAGATCCTGGAGAAGC
GCAAGGGGCCGCTGGAAGGCCACACAGAGAACGACCACCACAAGTTCCACCCTCTGCCCCGCTTCGAGCCCAAGAATGGGCTCATCCACG
GCGTGGCCCCCAGGAACGGCTTCCGCAGCAAGCTCAAGGAGGTGGGCCAGGCCCAGTTGAAGACTGGCCGGCGGCGACTCTTCGCTCAGG
AAAAAGAAGTGGTCAAGGAAGAGGAGGAGGACAAAGGCGTCCTCAATGACTTCCACAAGTGCATCTATAAGGGAAGGTCTGTTTCTCTAA
CAACTTTTTATCGAACAGCGAGGAATATCATGAGCATGTGTTTCAGCAAGGAGCCTGCCCCAGCCGAAATCGAGCAAGAGTACTGGAGGC
TAGTGGAAGAGAAGGACTGCCACGTGGCAGTGCACTGCGGCAAGGTGGACACCAACACTCACGGCAGTGGATTCCCAGTAGGAAAATCAG
AACCCTTTTCGAGGCATGGATGGAACCTCACCGTCCTCCCCAATAACACAGGGTCCATCCTGCGTCACCTCGGTGCTGTGCCTGGAGTGA
CTATTCCCTGGCTAAATATTGGCATGGTCTTTTCTACCTCATGCTGGTCTCGAGACCAAAATCACCTTCCATACATTGACTACTTACACA
CTGGTGCTGACTGCATTTGGTATTGCATTCCTGCTGAGGAGGAGAACAAGCTGGAAGATGTGGTCCACACCCTGCTGCAAGCCAATGGCA
CCCCAGGGCTGCAGATGCTGGAAAGCAACGTCATGATCTCCCCGGAGGTGCTGTGCAAAGAGGGGATCAAGGTGCACAGGACCGTGCAGC
AGAGTGGCCAGTTTGTCGTCTGCTTCCCGGGATCCTTTGTGTCCAAAGTGTGCTGTGGGTACAGCGTGTCTGAAACCGTGCACTTTGCTA
CCACCCAGTGGACAAGTATGGGCTTTGAGACCGCCAAGGAAATGAAGCGTCGCCATATAGCTAAGCCATTCTCCATGGAGAAGTTACTCT
ACCAGATTGCACAAGCAGAAGCAAAAAAAGAAAACGGTCCCACTCTCAGTACCATCTCAGCCCTCCTGGATGAGCTCAGGGATACAGAGC
TGCGGCAGCGCAGGCAGCTGTTCGAGGCTGGCCTCCACTCCTCCGCACGCTATGGCAGCCACGATGGCAGCAGCACGGTGGCGGACGGGA
AGAAAAAGCCTCGAAAGTGGCTGCAGTTGGAGACGTCAGAGAGGAGGTGTCAGATCTGCCAGCACCTGTGCTACCTGTCCATGGTGGTAC
AAGAGAACGAAAACGTCGTGTTCTGTCTGGAGTGTGCTCTGCGCCACGTGGAGAAACAGAAGTCCTGCCGAGGGCTGAAGTTGATGTACC
GCTACGATGAGGAACAGATTATCAGTCTGGTCAATCAGATCTGCGGCAAAGTGTCTGGTAAAAACGGCAGCATTGAGAACTGTCTCAGTA
AACCCACACCAAAAAGAGGTCCCCGCAAGAGAGCGACAGTGGACGTGCCCCCCTCCCGTCTGTCAGCCTCCAGTTCATCCAAAAGTGCTT
CGAGCTCATCATGAAGATGCCAACGCCCGTGGTCGATTTATATATATTTTTTTGTAATTATTATATTCTAGTTTGGAGTACTTGCTGTAG
GATTCAAGCTGTCTTTGCACTAGCTCTAAAGAAGATTTTCTTCTGGTTTTAGAGAACTAATTTTGTTTTAGCATTAAACTGTTGAACTTT
TTTTTGTACTTAGAAAACCTAGATACTGCAGTCAGATTTTGGAAACTGCCGTATAGTCACTGTTTTAAAAACCCCGGAGGGGCTGTATTA
ATTTGTATTGCCCCATGGCTGACAAAAGCCTTTTTTTTTGGTTTTGATTTTTTTTTTTTTGTAACTGTTGGGGGGAAAAAGGCTTTTTAA
CCCATTTTTGAAGAGGGTGAAGTTTGGAGAACAAATTTAAAAACCATCAGTCATGTGAGCAGATTTTTTAGAAGGGATAGGAGACACACG
CGCACACACACACACACACGAAACTTGAAATGGCTTTGCTTTGGCTGTCGTCTTCTGCCGTGTGCCAGATGAGCTTGTGATCTGGGAAGC
CGGGGCACCCCCGTTTTGTTTCTCTGGGCGGTTGTGGCAGCTGAAGGCGGACGTTGTTTCCTAACCATAGGTGGAACGAGGAGACGGGAG
CGAGTGGGCTCTCCACCAGCACATCACTATGCATCTGTTCCAGGAAAGAAGAAAAGCGAGCGAGGAAGACGGAAAAGACTGCCTGCCTTG
GAGGGGTCACATGAGGGAGACCTGTGCCTGATTTCATTAGGAAATCCATTCTGTTATTTTTTGGTGCTGTTGGCTACTTTATCAAAAAAC
CCTTCAATAGCATCCTTAAGATTTAAAAAAAAAAAAAAAAAAAAGGAAAAAAAAGTGATGGAAGCCGTAAGTGCTTCTTTGTCATCGACG
TGCAATCTTTCTAACATTCCATCTCCATCTCACCGCTTCTTGTTTGACACCTTCACAAGTCAGCATTAATCTTTCTTTTAAAACTTGTTT
CATTTATGATCATGTAGAGAGCCACTAGGAGGCCTGCAGTTATTTTTGAATGTGAAAATGCATTTGCGTTCATCTTGTCTATTTTTTCTC
TTCATGTTGTAACAAAAAGGAAAAAAGAAAAAAAAATCCCATCCCTTTTGTACATATGCCTGTAAATTGTTTTAAATACTTGAGCCTTTT
TCTCGGTGGGGGGTGGGGAGGGGGGTGAGAAGACAAGATGAAGAAAAGCCTTACATTTCAGTTTCTTCATCGGTTGGATTGGATGCTTAC
AGGGTTTTTCTTGTAACATTTATAAGTGCTGCTTACATCACTGAACAACAACAAAAAAATAATAATGGAGTAGCTGTTGCCCTTCTCCGG
TTGTGTGTACAGTATGTGTGGAATAAAAAAGGGAAACTGTTTTCACAAGCTGTTCTTTGTTTCATAATTGGATTCATCAATCCCGTAGCT
ACCCATATTGCACTGAGCTTGCCAGTGGTGACTGCCAGGAACGTCCTATGATCCACTTTGTTGGTTGTTGTTGCAGAAGACTGAACTGTT
TTGGAATATTTAACAATTACAGAAACAGTCAAGTGTTTTCCAATGTGGTTGTCCGGTTTCTATGGCCTTGCTGTGTACTTTCCCTCTTTT
TGACAGTAAACTTCTGCCTATGGCTTACAGTTTGACATTTAATTTATTAGCGCTGCTCTGCACCCCTCCCTTGGGAGGGAGACTTCATGT

>In-frame_ENST00000274695_ENST00000341776_TCGA-DX-A48N-01A_CDKAL1_chr6_20548936_-_JARID2_chr6_15487538_length(amino acids)=1118AA_start in transcript=167_stop in transcript=3523
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITVFNGSSRSTREKEPVQKHKSKEATPAKEKHSDHRADSRREQASANHPAAAPSTGSSAKGLAATHHHPPLHRSAQDLRKQVSKVNG
VTRMSSLGAGVTSAKKMREVRPSPSKTVKYTATVTKGAVTYTKAKRELVKDTKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASK
STGPAVNGLKVSGRLNPKSCTKEVGGRQLREGLQLREGLRNSKRRLEEAHQAEKPQSPPKKMKGAAGPAEGPGKKAPAERGLLNGHVKKE
VPERSLERNRPKRATAGKSTPGRQAHGKADSASCENRSTSQPESVHKPQDSGKAEKGGGKAGWAAMDEIPVLRPSAKEFHDPLIYIESVR
AQVEKFGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLKSQGITMDELPLIGGCELDLACFFRLINEMGGM
QQVTDLKKWNKLADMLRIPRTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTENDHHKFHPLPRFEPKN
GLIHGVAPRNGFRSKLKEVGQAQLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMSMCFSKEPAPAEIEQ
EYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYI
DYLHTGADCIWYCIPAEEENKLEDVVHTLLQANGTPGLQMLESNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYSVSET
VHFATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDELRDTELRQRRQLFEAGLHSSARYGSHDGSST
VADGKKKPRKWLQLETSERRCQICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQIISLVNQICGKVSGKNGSIE

--------------------------------------------------------------
>In-frame_ENST00000274695_ENST00000397311_TCGA-DX-A48N-01A_CDKAL1_chr6_20548936_-_JARID2_chr6_15487538_length(transcript)=3639nt_BP=453nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGCACTATTCCAGGCATACAGA
AAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCTAGCTGCTTATGGCTATAAAATTA
CAGTTTTCAATGGTTCCAGCAGGTCAACACGGGAGAAGGAACCTGTTCAAAAACACAAAAGCAAAGAGGCCACTCCCGCAAAGGAGAAGC
ACAGCGATCACCGGGCTGACAGCCGCCGGGAGCAGGCTTCAGCTAACCACCCCGCAGCGGCCCCCTCCACGGGTTCCTCGGCCAAGGGGC
TTGCTGCCACCCATCACCACCCCCCTCTGCATCGGTCGGCTCAGGACTTACGGAAACAGGTTTCTAAGGTAAACGGAGTCACTCGAATGT
CATCTCTGGGTGCAGGTGTAACCAGTGCCAAAAAGATGCGCGAGGTCAGACCTTCACCATCCAAAACTGTGAAGTACACTGCCACGGTGA
CGAAGGGGGCTGTCACATACACCAAAGCCAAGAGAGAACTGGTCAAGGACACCAAACCCAATCACCACAAGCCCAGTTCCGCTGTCAACC
ACACAATCTCAGGGAAAACTGAAAGTAGCAATGCAAAAACCCGCAAACAGGTGCTATCCCTCGGGGGGGCGTCCAAGTCCACTGGGCCCG
CCGTCAATGGCCTCAAGGTCAGTGGCAGGTTGAACCCAAAGTCATGCACTAAGGAGGTGGGGGGGCGGCAGCTGCGGGAGGGCCTGCAGC
TGCGGGAGGGGCTGCGGAACTCCAAGAGGAGACTGGAAGAGGCACACCAGGCGGAGAAGCCGCAGTCGCCCCCCAAGAAGATGAAAGGGG
CGGCTGGCCCCGCCGAAGGCCCTGGCAAGAAGGCCCCGGCCGAGAGAGGTCTGCTGAACGGACACGTGAAGAAGGAAGTGCCGGAGCGCA
GTCTGGAGAGGAATCGGCCGAAGCGGGCCACGGCCGGGAAGAGCACGCCAGGCAGACAAGCACATGGCAAGGCGGACAGCGCCTCCTGTG
AAAATCGTTCTACCTCGCAACCGGAGTCCGTGCACAAGCCGCAGGACTCGGGCAAGGCCGAGAAGGGCGGCGGCAAGGCCGGGTGGGCGG
CCATGGACGAGATCCCCGTCCTCAGGCCCTCCGCCAAGGAGTTCCACGATCCGCTCATCTACATCGAGTCGGTCCGCGCTCAGGTGGAGA
AGTTCGGGATGTGCAGGGTGATCCCCCCTCCGGACTGGCGGCCCGAGTGCAAGCTCAACGATGAGATGCGGTTTGTCACGCAGATTCAGC
ACATCCACAAGCTGGGCCGGCGCTGGGGCCCCAACGTGCAGCGGCTGGCCTGCATCAAGAAGCACCTCAAATCTCAGGGCATCACCATGG
ACGAGCTCCCGCTCATAGGGGGCTGTGAGCTCGACCTGGCCTGCTTTTTCCGGCTGATTAATGAGATGGGCGGCATGCAGCAAGTGACTG
ACCTCAAAAAATGGAACAAACTAGCAGACATGCTGCGCATCCCCAGAACTGCCCAGGACCGGCTGGCCAAGCTGCAGGAGGCCTACTGCC
AGTACCTACTCTCCTACGACTCCCTGTCCCCAGAGGAGCACCGGCGGCTGGAGAAGGAGGTGCTGATGGAGAAGGAGATCCTGGAGAAGC
GCAAGGGGCCGCTGGAAGGCCACACAGAGAACGACCACCACAAGTTCCACCCTCTGCCCCGCTTCGAGCCCAAGAATGGGCTCATCCACG
GCGTGGCCCCCAGGAACGGCTTCCGCAGCAAGCTCAAGGAGGTGGGCCAGGCCCAGTTGAAGACTGGCCGGCGGCGACTCTTCGCTCAGG
AAAAAGAAGTGGTCAAGGAAGAGGAGGAGGACAAAGGCGTCCTCAATGACTTCCACAAGTGCATCTATAAGGGAAGGTCTGTTTCTCTAA
CAACTTTTTATCGAACAGCGAGGAATATCATGAGCATGTGTTTCAGCAAGGAGCCTGCCCCAGCCGAAATCGAGCAAGAGTACTGGAGGC
TAGTGGAAGAGAAGGACTGCCACGTGGCAGTGCACTGCGGCAAGGTGGACACCAACACTCACGGCAGTGGATTCCCAGTAGGAAAATCAG
AACCCTTTTCGAGGCATGGATGGAACCTCACCGTCCTCCCCAATAACACAGGGTCCATCCTGCGTCACCTCGGTGCTGTGCCTGGAGTGA
CTATTCCCTGGCTAAATATTGGCATGGTCTTTTCTACCTCATGCTGGTCTCGAGACCAAAATCACCTTCCATACATTGACTACTTACACA
CTGGTGCTGACTGCATTTGGTATTGCATTCCTGCTGAGGAGGAGAACAAGCTGGAAGATGTGGTCCACACCCTGCTGCAAGCCAATGGCA
CCCCAGGGCTGCAGATGCTGGAAAGCAACGTCATGATCTCCCCGGAGGTGCTGTGCAAAGAGGGGATCAAGGTGCACAGGACCGTGCAGC
AGAGTGGCCAGTTTGTCGTCTGCTTCCCGGGATCCTTTGTGTCCAAAGTGTGCTGTGGGTACAGCGTGTCTGAAACCGTGCACTTTGCTA
CCACCCAGTGGACAAGTATGGGCTTTGAGACCGCCAAGGAAATGAAGCGTCGCCATATAGCTAAGCCATTCTCCATGGAGAAGTTACTCT
ACCAGATTGCACAAGCAGAAGCAAAAAAAGAAAACGGTCCCACTCTCAGTACCATCTCAGCCCTCCTGGATGAGCTCAGGGATACAGAGC
TGCGGCAGCGCAGGCAGCTGTTCGAGGCTGGCCTCCACTCCTCCGCACGCTATGGCAGCCACGATGGCAGCAGCACGGTGGCGGACGGGA
AGAAAAAGCCTCGAAAGTGGCTGCAGTTGGAGACGTCAGAGAGGAGGTGTCAGATCTGCCAGCACCTGTGCTACCTGTCCATGGTGGTAC
AAGAGAACGAAAACGTCGTGTTCTGTCTGGAGTGTGCTCTGCGCCACGTGGAGAAACAGAAGTCCTGCCGAGGGCTGAAGTTGATGTACC
GCTACGATGAGGAACAGATTATCAGTCTGGTCAATCAGATCTGCGGCAAAGTGTCTGGTAAAAACGGCAGCATTGAGAACTGTCTCAGTA
AACCCACACCAAAAAGAGGTCCCCGCAAGAGAGCGACAGTGGACGTGCCCCCCTCCCGTCTGTCAGCCTCCAGTTCATCCAAAAGTGCTT
CGAGCTCATCATGAAGATGCCAACGCCCGTGGTCGATTTATATATATTTTTTTGTAATTATTATATTCTAGTTTGGAGTACTTGCTGTAG

>In-frame_ENST00000274695_ENST00000397311_TCGA-DX-A48N-01A_CDKAL1_chr6_20548936_-_JARID2_chr6_15487538_length(amino acids)=1118AA_start in transcript=167_stop in transcript=3523
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITVFNGSSRSTREKEPVQKHKSKEATPAKEKHSDHRADSRREQASANHPAAAPSTGSSAKGLAATHHHPPLHRSAQDLRKQVSKVNG
VTRMSSLGAGVTSAKKMREVRPSPSKTVKYTATVTKGAVTYTKAKRELVKDTKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASK
STGPAVNGLKVSGRLNPKSCTKEVGGRQLREGLQLREGLRNSKRRLEEAHQAEKPQSPPKKMKGAAGPAEGPGKKAPAERGLLNGHVKKE
VPERSLERNRPKRATAGKSTPGRQAHGKADSASCENRSTSQPESVHKPQDSGKAEKGGGKAGWAAMDEIPVLRPSAKEFHDPLIYIESVR
AQVEKFGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLKSQGITMDELPLIGGCELDLACFFRLINEMGGM
QQVTDLKKWNKLADMLRIPRTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTENDHHKFHPLPRFEPKN
GLIHGVAPRNGFRSKLKEVGQAQLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMSMCFSKEPAPAEIEQ
EYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYI
DYLHTGADCIWYCIPAEEENKLEDVVHTLLQANGTPGLQMLESNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYSVSET
VHFATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDELRDTELRQRRQLFEAGLHSSARYGSHDGSST
VADGKKKPRKWLQLETSERRCQICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQIISLVNQICGKVSGKNGSIE

--------------------------------------------------------------
>In-frame_ENST00000274695_ENST00000541660_TCGA-DX-A48N-01A_CDKAL1_chr6_20548936_-_JARID2_chr6_15487538_length(transcript)=3020nt_BP=453nt
AAATAAACGTGGCGGGACGTATGTGTCATGGCGCTCTCCATCTAAAGTCTGTGCAGCTTCCGGAGAGTGGCGGGTTGATTTTCTCACTTT
GGACTGGTTTTTACTTCCCGACTTCTGGACTCATCTTTCAAGAGGACTTTAGACTAATTGCAGATAATTAAGAGAATATGCCTTCTGCAT
CCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAGGCATTTTGTAAGAAAGGATGTTG
TCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGACAGCACTATTCCAGGCATACAGA
AAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCTAGCTGCTTATGGCTATAAAATTA
CAGTTTTCAATGGTTCCAGCAGGTCAACACGGGAGAAGGAACCTGTTCAAAAACACAAAAGCAAAGAGGCCACTCCCGCAAAGGAGAAGC
ACAGCGATCACCGGGCTGACAGCCGCCGGGAGCAGGCTTCAGCTAACCACCCCGCAGCGGCCCCCTCCACGGGTTCCTCGGCCAAGGGGC
TTGCTGCCACCCATCACCACCCCCCTCTGCATCGGTCGGCTCAGGACTTACGGAAACAGGTTTCTAAGGTAAACGGAGTCACTCGAATGT
CATCTCTGGGTGCAGGTGTAACCAGTGCCAAAAAGATGCGCGAGGTCAGACCTTCACCATCCAAAACTGTGAAGTACACTGCCACGGTGA
CGAAGGGGGCTGTCACATACACCAAAGCCAAGAGAGAACTGGTCAAGGACACCAAACCCAATCACCACAAGCCCAGTTCCGCTGTCAACC
ACACAATCTCAGGGAAAACTGAAAGTAGCAATGCAAAAACCCGCAAACAGGTGCTATCCCTCGGGGGGGCGTCCAAGTCCACTGGGCCCG
CCGTCAATGGCCTCAAGGTCAGTGGCAGGTTGAACCCAAAGTCATGCACTAAGGAGGTGGGGGGGCGGCAGCTGCGGGAGGGCCTGCAGC
TGCGGGAGGGGCTGCGGAACTCCAAGAGGAGACTGGAAGAGGCACACCAGGCGGAGAAGCCGCAGTCGCCCCCCAAGAAGATGAAAGGGG
CGGCTGGCCCCGCCGAAGGCCCTGGCAAGAAGGCCCCGGCCGAGAGAGGTCTGCTGAACGGACACGTGAAGAAGGAAGTGCCGGAGCGCA
GTCTGGAGAGGAATCGGCCGAAGCGGGCCACGGCCGGGAAGAGCACGCCAGGCAGACAAGCACATGGCAAGGCGGACAGCGCCTCCTGTG
AAAATCGTTCTACCTCGCAACCGGAGTCCGTGCACAAGCCGCAGGACTCGGGCAAGGCCGAGAAGGGCGGCGGCAAGGCCGGGTGGGCGG
CCATGGACGAGATCCCCGTCCTCAGGCCCTCCGCCAAGGAGTTCCACGATCCGCTCATCTACATCGAGTCGGTCCGCGCTCAGGTGGAGA
AGTTCGGGATGTGCAGGGTGATCCCCCCTCCGGACTGGCGGCCCGAGTGCAAGCTCAACGATGAGATGCGGTTTGTCACGCAGATTCAGC
ACATCCACAAGCTGGGCCGGCGCTGGGGCCCCAACGTGCAGCGGCTGGCCTGCATCAAGAAGCACCTCAAATCTCAGGGCATCACCATGG
ACGAGCTCCCGCTCATAGGGGGCTGTGAGCTCGACCTGGCCTGCTTTTTCCGGCTGATTAATGAGATGGGCGGCATGCAGCAAGTGACTG
ACCTCAAAAAATGGAACAAACTAGCAGACATGCTGCGCATCCCCAGAACTGCCCAGGACCGGCTGGCCAAGCTGCAGGAGGCCTACTGCC
AGTACCTACTCTCCTACGACTCCCTGTCCCCAGAGGAGCACCGGCGGCTGGAGAAGGAGGTGCTGATGGAGAAGGAGATCCTGGAGAAGC
GCAAGGGGCCGCTGGAAGGCCACACAGAGAACGACCACCACAAGTTCCACCCTCTGCCCCGCTTCGAGCCCAAGAATGGGCTCATCCACG
GCGTGGCCCCCAGGAACGGCTTCCGCAGCAAGCTCAAGGAGGTGGGCCAGGCCCAGTTGAAGACTGGCCGGCGGCGACTCTTCGCTCAGG
AAAAAGAAGTGGTCAAGGAAGAGGAGGAGGACAAAGGCGTCCTCAATGACTTCCACAAGTGCATCTATAAGGGAAGGTCTGTTTCTCTAA
CAACTTTTTATCGAACAGCGAGGAATATCATGAGCATGTGTTTCAGCAAGGAGCCTGCCCCAGCCGAAATCGAGCAAGAGTACTGGAGGC
TAGTGGAAGAGAAGGACTGCCACGTGGCAGTGCACTGCGGCAAGGTGGACACCAACACTCACGGCAGTGGATTCCCAGTAGGAAAATCAG
AACCCTTTTCGAGGCATGGATGGAACCTCACCGTCCTCCCCAATAACACAGGGTCCATCCTGCGTCACCTCGGTGCTGTGCCTGGAGTGA
CTATTCCCTGGCTAAATATTGGCATGGTCTTTTCTACCTCATGCTGGTCTCGAGACCAAAATCACCTTCCATACATTGACTACTTACACA
CTGGTGCTGACTGCATTTGCCTCTCTGTAGAGCCAGTGTTTCCTCATCTATCGGTGGCTGTGGGGAGTAGAGTTGACTTGGGAATCTCGT
TCCTGCCATGTGGAGACACGCGCGTTATGTACCCTGTGGAGTCTGTTGCCTGGCGAGGTGTTCTGGGTCCCCGCCTGTAATCTGACTCTC
ACTGTAGCCATCCCTGATTGAGGCTGGGTCCCCGCCTGTAATCCTGACTCTCACTGCACCCATCCCTGATCGAGGCTGGACTCTTTGGTG
TCTTTGTTTACGGCGGCAGATGGGAAATGACTACAAATAATCAGATGTCTTGTCGTCTGATCGTTTACCGGCATGCTGTTCATGCCATGC

>In-frame_ENST00000274695_ENST00000541660_TCGA-DX-A48N-01A_CDKAL1_chr6_20548936_-_JARID2_chr6_15487538_length(amino acids)=870AA_start in transcript=167_stop in transcript=2779
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITVFNGSSRSTREKEPVQKHKSKEATPAKEKHSDHRADSRREQASANHPAAAPSTGSSAKGLAATHHHPPLHRSAQDLRKQVSKVNG
VTRMSSLGAGVTSAKKMREVRPSPSKTVKYTATVTKGAVTYTKAKRELVKDTKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASK
STGPAVNGLKVSGRLNPKSCTKEVGGRQLREGLQLREGLRNSKRRLEEAHQAEKPQSPPKKMKGAAGPAEGPGKKAPAERGLLNGHVKKE
VPERSLERNRPKRATAGKSTPGRQAHGKADSASCENRSTSQPESVHKPQDSGKAEKGGGKAGWAAMDEIPVLRPSAKEFHDPLIYIESVR
AQVEKFGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLKSQGITMDELPLIGGCELDLACFFRLINEMGGM
QQVTDLKKWNKLADMLRIPRTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTENDHHKFHPLPRFEPKN
GLIHGVAPRNGFRSKLKEVGQAQLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMSMCFSKEPAPAEIEQ
EYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYI

--------------------------------------------------------------
>In-frame_ENST00000378610_ENST00000341776_TCGA-DX-A48N-01A_CDKAL1_chr6_20548936_-_JARID2_chr6_15487538_length(transcript)=5137nt_BP=296nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGCACTATTCCAGGCATACAGAAAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCT
AGCTGCTTATGGCTATAAAATTACAGTTTTCAATGGTTCCAGCAGGTCAACACGGGAGAAGGAACCTGTTCAAAAACACAAAAGCAAAGA
GGCCACTCCCGCAAAGGAGAAGCACAGCGATCACCGGGCTGACAGCCGCCGGGAGCAGGCTTCAGCTAACCACCCCGCAGCGGCCCCCTC
CACGGGTTCCTCGGCCAAGGGGCTTGCTGCCACCCATCACCACCCCCCTCTGCATCGGTCGGCTCAGGACTTACGGAAACAGGTTTCTAA
GGTAAACGGAGTCACTCGAATGTCATCTCTGGGTGCAGGTGTAACCAGTGCCAAAAAGATGCGCGAGGTCAGACCTTCACCATCCAAAAC
TGTGAAGTACACTGCCACGGTGACGAAGGGGGCTGTCACATACACCAAAGCCAAGAGAGAACTGGTCAAGGACACCAAACCCAATCACCA
CAAGCCCAGTTCCGCTGTCAACCACACAATCTCAGGGAAAACTGAAAGTAGCAATGCAAAAACCCGCAAACAGGTGCTATCCCTCGGGGG
GGCGTCCAAGTCCACTGGGCCCGCCGTCAATGGCCTCAAGGTCAGTGGCAGGTTGAACCCAAAGTCATGCACTAAGGAGGTGGGGGGGCG
GCAGCTGCGGGAGGGCCTGCAGCTGCGGGAGGGGCTGCGGAACTCCAAGAGGAGACTGGAAGAGGCACACCAGGCGGAGAAGCCGCAGTC
GCCCCCCAAGAAGATGAAAGGGGCGGCTGGCCCCGCCGAAGGCCCTGGCAAGAAGGCCCCGGCCGAGAGAGGTCTGCTGAACGGACACGT
GAAGAAGGAAGTGCCGGAGCGCAGTCTGGAGAGGAATCGGCCGAAGCGGGCCACGGCCGGGAAGAGCACGCCAGGCAGACAAGCACATGG
CAAGGCGGACAGCGCCTCCTGTGAAAATCGTTCTACCTCGCAACCGGAGTCCGTGCACAAGCCGCAGGACTCGGGCAAGGCCGAGAAGGG
CGGCGGCAAGGCCGGGTGGGCGGCCATGGACGAGATCCCCGTCCTCAGGCCCTCCGCCAAGGAGTTCCACGATCCGCTCATCTACATCGA
GTCGGTCCGCGCTCAGGTGGAGAAGTTCGGGATGTGCAGGGTGATCCCCCCTCCGGACTGGCGGCCCGAGTGCAAGCTCAACGATGAGAT
GCGGTTTGTCACGCAGATTCAGCACATCCACAAGCTGGGCCGGCGCTGGGGCCCCAACGTGCAGCGGCTGGCCTGCATCAAGAAGCACCT
CAAATCTCAGGGCATCACCATGGACGAGCTCCCGCTCATAGGGGGCTGTGAGCTCGACCTGGCCTGCTTTTTCCGGCTGATTAATGAGAT
GGGCGGCATGCAGCAAGTGACTGACCTCAAAAAATGGAACAAACTAGCAGACATGCTGCGCATCCCCAGAACTGCCCAGGACCGGCTGGC
CAAGCTGCAGGAGGCCTACTGCCAGTACCTACTCTCCTACGACTCCCTGTCCCCAGAGGAGCACCGGCGGCTGGAGAAGGAGGTGCTGAT
GGAGAAGGAGATCCTGGAGAAGCGCAAGGGGCCGCTGGAAGGCCACACAGAGAACGACCACCACAAGTTCCACCCTCTGCCCCGCTTCGA
GCCCAAGAATGGGCTCATCCACGGCGTGGCCCCCAGGAACGGCTTCCGCAGCAAGCTCAAGGAGGTGGGCCAGGCCCAGTTGAAGACTGG
CCGGCGGCGACTCTTCGCTCAGGAAAAAGAAGTGGTCAAGGAAGAGGAGGAGGACAAAGGCGTCCTCAATGACTTCCACAAGTGCATCTA
TAAGGGAAGGTCTGTTTCTCTAACAACTTTTTATCGAACAGCGAGGAATATCATGAGCATGTGTTTCAGCAAGGAGCCTGCCCCAGCCGA
AATCGAGCAAGAGTACTGGAGGCTAGTGGAAGAGAAGGACTGCCACGTGGCAGTGCACTGCGGCAAGGTGGACACCAACACTCACGGCAG
TGGATTCCCAGTAGGAAAATCAGAACCCTTTTCGAGGCATGGATGGAACCTCACCGTCCTCCCCAATAACACAGGGTCCATCCTGCGTCA
CCTCGGTGCTGTGCCTGGAGTGACTATTCCCTGGCTAAATATTGGCATGGTCTTTTCTACCTCATGCTGGTCTCGAGACCAAAATCACCT
TCCATACATTGACTACTTACACACTGGTGCTGACTGCATTTGGTATTGCATTCCTGCTGAGGAGGAGAACAAGCTGGAAGATGTGGTCCA
CACCCTGCTGCAAGCCAATGGCACCCCAGGGCTGCAGATGCTGGAAAGCAACGTCATGATCTCCCCGGAGGTGCTGTGCAAAGAGGGGAT
CAAGGTGCACAGGACCGTGCAGCAGAGTGGCCAGTTTGTCGTCTGCTTCCCGGGATCCTTTGTGTCCAAAGTGTGCTGTGGGTACAGCGT
GTCTGAAACCGTGCACTTTGCTACCACCCAGTGGACAAGTATGGGCTTTGAGACCGCCAAGGAAATGAAGCGTCGCCATATAGCTAAGCC
ATTCTCCATGGAGAAGTTACTCTACCAGATTGCACAAGCAGAAGCAAAAAAAGAAAACGGTCCCACTCTCAGTACCATCTCAGCCCTCCT
GGATGAGCTCAGGGATACAGAGCTGCGGCAGCGCAGGCAGCTGTTCGAGGCTGGCCTCCACTCCTCCGCACGCTATGGCAGCCACGATGG
CAGCAGCACGGTGGCGGACGGGAAGAAAAAGCCTCGAAAGTGGCTGCAGTTGGAGACGTCAGAGAGGAGGTGTCAGATCTGCCAGCACCT
GTGCTACCTGTCCATGGTGGTACAAGAGAACGAAAACGTCGTGTTCTGTCTGGAGTGTGCTCTGCGCCACGTGGAGAAACAGAAGTCCTG
CCGAGGGCTGAAGTTGATGTACCGCTACGATGAGGAACAGATTATCAGTCTGGTCAATCAGATCTGCGGCAAAGTGTCTGGTAAAAACGG
CAGCATTGAGAACTGTCTCAGTAAACCCACACCAAAAAGAGGTCCCCGCAAGAGAGCGACAGTGGACGTGCCCCCCTCCCGTCTGTCAGC
CTCCAGTTCATCCAAAAGTGCTTCGAGCTCATCATGAAGATGCCAACGCCCGTGGTCGATTTATATATATTTTTTTGTAATTATTATATT
CTAGTTTGGAGTACTTGCTGTAGGATTCAAGCTGTCTTTGCACTAGCTCTAAAGAAGATTTTCTTCTGGTTTTAGAGAACTAATTTTGTT
TTAGCATTAAACTGTTGAACTTTTTTTTGTACTTAGAAAACCTAGATACTGCAGTCAGATTTTGGAAACTGCCGTATAGTCACTGTTTTA
AAAACCCCGGAGGGGCTGTATTAATTTGTATTGCCCCATGGCTGACAAAAGCCTTTTTTTTTGGTTTTGATTTTTTTTTTTTTGTAACTG
TTGGGGGGAAAAAGGCTTTTTAACCCATTTTTGAAGAGGGTGAAGTTTGGAGAACAAATTTAAAAACCATCAGTCATGTGAGCAGATTTT
TTAGAAGGGATAGGAGACACACGCGCACACACACACACACACGAAACTTGAAATGGCTTTGCTTTGGCTGTCGTCTTCTGCCGTGTGCCA
GATGAGCTTGTGATCTGGGAAGCCGGGGCACCCCCGTTTTGTTTCTCTGGGCGGTTGTGGCAGCTGAAGGCGGACGTTGTTTCCTAACCA
TAGGTGGAACGAGGAGACGGGAGCGAGTGGGCTCTCCACCAGCACATCACTATGCATCTGTTCCAGGAAAGAAGAAAAGCGAGCGAGGAA
GACGGAAAAGACTGCCTGCCTTGGAGGGGTCACATGAGGGAGACCTGTGCCTGATTTCATTAGGAAATCCATTCTGTTATTTTTTGGTGC
TGTTGGCTACTTTATCAAAAAACCCTTCAATAGCATCCTTAAGATTTAAAAAAAAAAAAAAAAAAAAGGAAAAAAAAGTGATGGAAGCCG
TAAGTGCTTCTTTGTCATCGACGTGCAATCTTTCTAACATTCCATCTCCATCTCACCGCTTCTTGTTTGACACCTTCACAAGTCAGCATT
AATCTTTCTTTTAAAACTTGTTTCATTTATGATCATGTAGAGAGCCACTAGGAGGCCTGCAGTTATTTTTGAATGTGAAAATGCATTTGC
GTTCATCTTGTCTATTTTTTCTCTTCATGTTGTAACAAAAAGGAAAAAAGAAAAAAAAATCCCATCCCTTTTGTACATATGCCTGTAAAT
TGTTTTAAATACTTGAGCCTTTTTCTCGGTGGGGGGTGGGGAGGGGGGTGAGAAGACAAGATGAAGAAAAGCCTTACATTTCAGTTTCTT
CATCGGTTGGATTGGATGCTTACAGGGTTTTTCTTGTAACATTTATAAGTGCTGCTTACATCACTGAACAACAACAAAAAAATAATAATG
GAGTAGCTGTTGCCCTTCTCCGGTTGTGTGTACAGTATGTGTGGAATAAAAAAGGGAAACTGTTTTCACAAGCTGTTCTTTGTTTCATAA
TTGGATTCATCAATCCCGTAGCTACCCATATTGCACTGAGCTTGCCAGTGGTGACTGCCAGGAACGTCCTATGATCCACTTTGTTGGTTG
TTGTTGCAGAAGACTGAACTGTTTTGGAATATTTAACAATTACAGAAACAGTCAAGTGTTTTCCAATGTGGTTGTCCGGTTTCTATGGCC
TTGCTGTGTACTTTCCCTCTTTTTGACAGTAAACTTCTGCCTATGGCTTACAGTTTGACATTTAATTTATTAGCGCTGCTCTGCACCCCT
CCCTTGGGAGGGAGACTTCATGTGGTTTATTGCGAGTTTTTTGTTTACTTTTCAGGTTTGTACTACAAGGTTTAATAATAAAAACAAAGT

>In-frame_ENST00000378610_ENST00000341776_TCGA-DX-A48N-01A_CDKAL1_chr6_20548936_-_JARID2_chr6_15487538_length(amino acids)=1118AA_start in transcript=10_stop in transcript=3366
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITVFNGSSRSTREKEPVQKHKSKEATPAKEKHSDHRADSRREQASANHPAAAPSTGSSAKGLAATHHHPPLHRSAQDLRKQVSKVNG
VTRMSSLGAGVTSAKKMREVRPSPSKTVKYTATVTKGAVTYTKAKRELVKDTKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASK
STGPAVNGLKVSGRLNPKSCTKEVGGRQLREGLQLREGLRNSKRRLEEAHQAEKPQSPPKKMKGAAGPAEGPGKKAPAERGLLNGHVKKE
VPERSLERNRPKRATAGKSTPGRQAHGKADSASCENRSTSQPESVHKPQDSGKAEKGGGKAGWAAMDEIPVLRPSAKEFHDPLIYIESVR
AQVEKFGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLKSQGITMDELPLIGGCELDLACFFRLINEMGGM
QQVTDLKKWNKLADMLRIPRTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTENDHHKFHPLPRFEPKN
GLIHGVAPRNGFRSKLKEVGQAQLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMSMCFSKEPAPAEIEQ
EYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYI
DYLHTGADCIWYCIPAEEENKLEDVVHTLLQANGTPGLQMLESNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYSVSET
VHFATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDELRDTELRQRRQLFEAGLHSSARYGSHDGSST
VADGKKKPRKWLQLETSERRCQICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQIISLVNQICGKVSGKNGSIE

--------------------------------------------------------------
>In-frame_ENST00000378610_ENST00000397311_TCGA-DX-A48N-01A_CDKAL1_chr6_20548936_-_JARID2_chr6_15487538_length(transcript)=3482nt_BP=296nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGCACTATTCCAGGCATACAGAAAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCT
AGCTGCTTATGGCTATAAAATTACAGTTTTCAATGGTTCCAGCAGGTCAACACGGGAGAAGGAACCTGTTCAAAAACACAAAAGCAAAGA
GGCCACTCCCGCAAAGGAGAAGCACAGCGATCACCGGGCTGACAGCCGCCGGGAGCAGGCTTCAGCTAACCACCCCGCAGCGGCCCCCTC
CACGGGTTCCTCGGCCAAGGGGCTTGCTGCCACCCATCACCACCCCCCTCTGCATCGGTCGGCTCAGGACTTACGGAAACAGGTTTCTAA
GGTAAACGGAGTCACTCGAATGTCATCTCTGGGTGCAGGTGTAACCAGTGCCAAAAAGATGCGCGAGGTCAGACCTTCACCATCCAAAAC
TGTGAAGTACACTGCCACGGTGACGAAGGGGGCTGTCACATACACCAAAGCCAAGAGAGAACTGGTCAAGGACACCAAACCCAATCACCA
CAAGCCCAGTTCCGCTGTCAACCACACAATCTCAGGGAAAACTGAAAGTAGCAATGCAAAAACCCGCAAACAGGTGCTATCCCTCGGGGG
GGCGTCCAAGTCCACTGGGCCCGCCGTCAATGGCCTCAAGGTCAGTGGCAGGTTGAACCCAAAGTCATGCACTAAGGAGGTGGGGGGGCG
GCAGCTGCGGGAGGGCCTGCAGCTGCGGGAGGGGCTGCGGAACTCCAAGAGGAGACTGGAAGAGGCACACCAGGCGGAGAAGCCGCAGTC
GCCCCCCAAGAAGATGAAAGGGGCGGCTGGCCCCGCCGAAGGCCCTGGCAAGAAGGCCCCGGCCGAGAGAGGTCTGCTGAACGGACACGT
GAAGAAGGAAGTGCCGGAGCGCAGTCTGGAGAGGAATCGGCCGAAGCGGGCCACGGCCGGGAAGAGCACGCCAGGCAGACAAGCACATGG
CAAGGCGGACAGCGCCTCCTGTGAAAATCGTTCTACCTCGCAACCGGAGTCCGTGCACAAGCCGCAGGACTCGGGCAAGGCCGAGAAGGG
CGGCGGCAAGGCCGGGTGGGCGGCCATGGACGAGATCCCCGTCCTCAGGCCCTCCGCCAAGGAGTTCCACGATCCGCTCATCTACATCGA
GTCGGTCCGCGCTCAGGTGGAGAAGTTCGGGATGTGCAGGGTGATCCCCCCTCCGGACTGGCGGCCCGAGTGCAAGCTCAACGATGAGAT
GCGGTTTGTCACGCAGATTCAGCACATCCACAAGCTGGGCCGGCGCTGGGGCCCCAACGTGCAGCGGCTGGCCTGCATCAAGAAGCACCT
CAAATCTCAGGGCATCACCATGGACGAGCTCCCGCTCATAGGGGGCTGTGAGCTCGACCTGGCCTGCTTTTTCCGGCTGATTAATGAGAT
GGGCGGCATGCAGCAAGTGACTGACCTCAAAAAATGGAACAAACTAGCAGACATGCTGCGCATCCCCAGAACTGCCCAGGACCGGCTGGC
CAAGCTGCAGGAGGCCTACTGCCAGTACCTACTCTCCTACGACTCCCTGTCCCCAGAGGAGCACCGGCGGCTGGAGAAGGAGGTGCTGAT
GGAGAAGGAGATCCTGGAGAAGCGCAAGGGGCCGCTGGAAGGCCACACAGAGAACGACCACCACAAGTTCCACCCTCTGCCCCGCTTCGA
GCCCAAGAATGGGCTCATCCACGGCGTGGCCCCCAGGAACGGCTTCCGCAGCAAGCTCAAGGAGGTGGGCCAGGCCCAGTTGAAGACTGG
CCGGCGGCGACTCTTCGCTCAGGAAAAAGAAGTGGTCAAGGAAGAGGAGGAGGACAAAGGCGTCCTCAATGACTTCCACAAGTGCATCTA
TAAGGGAAGGTCTGTTTCTCTAACAACTTTTTATCGAACAGCGAGGAATATCATGAGCATGTGTTTCAGCAAGGAGCCTGCCCCAGCCGA
AATCGAGCAAGAGTACTGGAGGCTAGTGGAAGAGAAGGACTGCCACGTGGCAGTGCACTGCGGCAAGGTGGACACCAACACTCACGGCAG
TGGATTCCCAGTAGGAAAATCAGAACCCTTTTCGAGGCATGGATGGAACCTCACCGTCCTCCCCAATAACACAGGGTCCATCCTGCGTCA
CCTCGGTGCTGTGCCTGGAGTGACTATTCCCTGGCTAAATATTGGCATGGTCTTTTCTACCTCATGCTGGTCTCGAGACCAAAATCACCT
TCCATACATTGACTACTTACACACTGGTGCTGACTGCATTTGGTATTGCATTCCTGCTGAGGAGGAGAACAAGCTGGAAGATGTGGTCCA
CACCCTGCTGCAAGCCAATGGCACCCCAGGGCTGCAGATGCTGGAAAGCAACGTCATGATCTCCCCGGAGGTGCTGTGCAAAGAGGGGAT
CAAGGTGCACAGGACCGTGCAGCAGAGTGGCCAGTTTGTCGTCTGCTTCCCGGGATCCTTTGTGTCCAAAGTGTGCTGTGGGTACAGCGT
GTCTGAAACCGTGCACTTTGCTACCACCCAGTGGACAAGTATGGGCTTTGAGACCGCCAAGGAAATGAAGCGTCGCCATATAGCTAAGCC
ATTCTCCATGGAGAAGTTACTCTACCAGATTGCACAAGCAGAAGCAAAAAAAGAAAACGGTCCCACTCTCAGTACCATCTCAGCCCTCCT
GGATGAGCTCAGGGATACAGAGCTGCGGCAGCGCAGGCAGCTGTTCGAGGCTGGCCTCCACTCCTCCGCACGCTATGGCAGCCACGATGG
CAGCAGCACGGTGGCGGACGGGAAGAAAAAGCCTCGAAAGTGGCTGCAGTTGGAGACGTCAGAGAGGAGGTGTCAGATCTGCCAGCACCT
GTGCTACCTGTCCATGGTGGTACAAGAGAACGAAAACGTCGTGTTCTGTCTGGAGTGTGCTCTGCGCCACGTGGAGAAACAGAAGTCCTG
CCGAGGGCTGAAGTTGATGTACCGCTACGATGAGGAACAGATTATCAGTCTGGTCAATCAGATCTGCGGCAAAGTGTCTGGTAAAAACGG
CAGCATTGAGAACTGTCTCAGTAAACCCACACCAAAAAGAGGTCCCCGCAAGAGAGCGACAGTGGACGTGCCCCCCTCCCGTCTGTCAGC
CTCCAGTTCATCCAAAAGTGCTTCGAGCTCATCATGAAGATGCCAACGCCCGTGGTCGATTTATATATATTTTTTTGTAATTATTATATT

>In-frame_ENST00000378610_ENST00000397311_TCGA-DX-A48N-01A_CDKAL1_chr6_20548936_-_JARID2_chr6_15487538_length(amino acids)=1118AA_start in transcript=10_stop in transcript=3366
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITVFNGSSRSTREKEPVQKHKSKEATPAKEKHSDHRADSRREQASANHPAAAPSTGSSAKGLAATHHHPPLHRSAQDLRKQVSKVNG
VTRMSSLGAGVTSAKKMREVRPSPSKTVKYTATVTKGAVTYTKAKRELVKDTKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASK
STGPAVNGLKVSGRLNPKSCTKEVGGRQLREGLQLREGLRNSKRRLEEAHQAEKPQSPPKKMKGAAGPAEGPGKKAPAERGLLNGHVKKE
VPERSLERNRPKRATAGKSTPGRQAHGKADSASCENRSTSQPESVHKPQDSGKAEKGGGKAGWAAMDEIPVLRPSAKEFHDPLIYIESVR
AQVEKFGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLKSQGITMDELPLIGGCELDLACFFRLINEMGGM
QQVTDLKKWNKLADMLRIPRTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTENDHHKFHPLPRFEPKN
GLIHGVAPRNGFRSKLKEVGQAQLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMSMCFSKEPAPAEIEQ
EYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYI
DYLHTGADCIWYCIPAEEENKLEDVVHTLLQANGTPGLQMLESNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSKVCCGYSVSET
VHFATTQWTSMGFETAKEMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLSTISALLDELRDTELRQRRQLFEAGLHSSARYGSHDGSST
VADGKKKPRKWLQLETSERRCQICQHLCYLSMVVQENENVVFCLECALRHVEKQKSCRGLKLMYRYDEEQIISLVNQICGKVSGKNGSIE

--------------------------------------------------------------
>In-frame_ENST00000378610_ENST00000541660_TCGA-DX-A48N-01A_CDKAL1_chr6_20548936_-_JARID2_chr6_15487538_length(transcript)=2863nt_BP=296nt
GGTAGAGAATATGCCTTCTGCATCCTGTGATACACTACTGGATGACATCGAAGATATCGTGTCTCAGGAAGATTCAAAACCACAAGATAG
GCATTTTGTAAGAAAGGATGTTGTCCCGAAGGTACGAAGGCGAAATACCCAAAAATATTTGCAAGAGGAAGAAAACAGTCCACCAAGTGA
CAGCACTATTCCAGGCATACAGAAAATTTGGATACGAACATGGGGTTGTTCTCATAATAATTCAGATGGAGAATATATGGCTGGACAGCT
AGCTGCTTATGGCTATAAAATTACAGTTTTCAATGGTTCCAGCAGGTCAACACGGGAGAAGGAACCTGTTCAAAAACACAAAAGCAAAGA
GGCCACTCCCGCAAAGGAGAAGCACAGCGATCACCGGGCTGACAGCCGCCGGGAGCAGGCTTCAGCTAACCACCCCGCAGCGGCCCCCTC
CACGGGTTCCTCGGCCAAGGGGCTTGCTGCCACCCATCACCACCCCCCTCTGCATCGGTCGGCTCAGGACTTACGGAAACAGGTTTCTAA
GGTAAACGGAGTCACTCGAATGTCATCTCTGGGTGCAGGTGTAACCAGTGCCAAAAAGATGCGCGAGGTCAGACCTTCACCATCCAAAAC
TGTGAAGTACACTGCCACGGTGACGAAGGGGGCTGTCACATACACCAAAGCCAAGAGAGAACTGGTCAAGGACACCAAACCCAATCACCA
CAAGCCCAGTTCCGCTGTCAACCACACAATCTCAGGGAAAACTGAAAGTAGCAATGCAAAAACCCGCAAACAGGTGCTATCCCTCGGGGG
GGCGTCCAAGTCCACTGGGCCCGCCGTCAATGGCCTCAAGGTCAGTGGCAGGTTGAACCCAAAGTCATGCACTAAGGAGGTGGGGGGGCG
GCAGCTGCGGGAGGGCCTGCAGCTGCGGGAGGGGCTGCGGAACTCCAAGAGGAGACTGGAAGAGGCACACCAGGCGGAGAAGCCGCAGTC
GCCCCCCAAGAAGATGAAAGGGGCGGCTGGCCCCGCCGAAGGCCCTGGCAAGAAGGCCCCGGCCGAGAGAGGTCTGCTGAACGGACACGT
GAAGAAGGAAGTGCCGGAGCGCAGTCTGGAGAGGAATCGGCCGAAGCGGGCCACGGCCGGGAAGAGCACGCCAGGCAGACAAGCACATGG
CAAGGCGGACAGCGCCTCCTGTGAAAATCGTTCTACCTCGCAACCGGAGTCCGTGCACAAGCCGCAGGACTCGGGCAAGGCCGAGAAGGG
CGGCGGCAAGGCCGGGTGGGCGGCCATGGACGAGATCCCCGTCCTCAGGCCCTCCGCCAAGGAGTTCCACGATCCGCTCATCTACATCGA
GTCGGTCCGCGCTCAGGTGGAGAAGTTCGGGATGTGCAGGGTGATCCCCCCTCCGGACTGGCGGCCCGAGTGCAAGCTCAACGATGAGAT
GCGGTTTGTCACGCAGATTCAGCACATCCACAAGCTGGGCCGGCGCTGGGGCCCCAACGTGCAGCGGCTGGCCTGCATCAAGAAGCACCT
CAAATCTCAGGGCATCACCATGGACGAGCTCCCGCTCATAGGGGGCTGTGAGCTCGACCTGGCCTGCTTTTTCCGGCTGATTAATGAGAT
GGGCGGCATGCAGCAAGTGACTGACCTCAAAAAATGGAACAAACTAGCAGACATGCTGCGCATCCCCAGAACTGCCCAGGACCGGCTGGC
CAAGCTGCAGGAGGCCTACTGCCAGTACCTACTCTCCTACGACTCCCTGTCCCCAGAGGAGCACCGGCGGCTGGAGAAGGAGGTGCTGAT
GGAGAAGGAGATCCTGGAGAAGCGCAAGGGGCCGCTGGAAGGCCACACAGAGAACGACCACCACAAGTTCCACCCTCTGCCCCGCTTCGA
GCCCAAGAATGGGCTCATCCACGGCGTGGCCCCCAGGAACGGCTTCCGCAGCAAGCTCAAGGAGGTGGGCCAGGCCCAGTTGAAGACTGG
CCGGCGGCGACTCTTCGCTCAGGAAAAAGAAGTGGTCAAGGAAGAGGAGGAGGACAAAGGCGTCCTCAATGACTTCCACAAGTGCATCTA
TAAGGGAAGGTCTGTTTCTCTAACAACTTTTTATCGAACAGCGAGGAATATCATGAGCATGTGTTTCAGCAAGGAGCCTGCCCCAGCCGA
AATCGAGCAAGAGTACTGGAGGCTAGTGGAAGAGAAGGACTGCCACGTGGCAGTGCACTGCGGCAAGGTGGACACCAACACTCACGGCAG
TGGATTCCCAGTAGGAAAATCAGAACCCTTTTCGAGGCATGGATGGAACCTCACCGTCCTCCCCAATAACACAGGGTCCATCCTGCGTCA
CCTCGGTGCTGTGCCTGGAGTGACTATTCCCTGGCTAAATATTGGCATGGTCTTTTCTACCTCATGCTGGTCTCGAGACCAAAATCACCT
TCCATACATTGACTACTTACACACTGGTGCTGACTGCATTTGCCTCTCTGTAGAGCCAGTGTTTCCTCATCTATCGGTGGCTGTGGGGAG
TAGAGTTGACTTGGGAATCTCGTTCCTGCCATGTGGAGACACGCGCGTTATGTACCCTGTGGAGTCTGTTGCCTGGCGAGGTGTTCTGGG
TCCCCGCCTGTAATCTGACTCTCACTGTAGCCATCCCTGATTGAGGCTGGGTCCCCGCCTGTAATCCTGACTCTCACTGCACCCATCCCT
GATCGAGGCTGGACTCTTTGGTGTCTTTGTTTACGGCGGCAGATGGGAAATGACTACAAATAATCAGATGTCTTGTCGTCTGATCGTTTA

>In-frame_ENST00000378610_ENST00000541660_TCGA-DX-A48N-01A_CDKAL1_chr6_20548936_-_JARID2_chr6_15487538_length(amino acids)=870AA_start in transcript=10_stop in transcript=2622
MPSASCDTLLDDIEDIVSQEDSKPQDRHFVRKDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAY
GYKITVFNGSSRSTREKEPVQKHKSKEATPAKEKHSDHRADSRREQASANHPAAAPSTGSSAKGLAATHHHPPLHRSAQDLRKQVSKVNG
VTRMSSLGAGVTSAKKMREVRPSPSKTVKYTATVTKGAVTYTKAKRELVKDTKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASK
STGPAVNGLKVSGRLNPKSCTKEVGGRQLREGLQLREGLRNSKRRLEEAHQAEKPQSPPKKMKGAAGPAEGPGKKAPAERGLLNGHVKKE
VPERSLERNRPKRATAGKSTPGRQAHGKADSASCENRSTSQPESVHKPQDSGKAEKGGGKAGWAAMDEIPVLRPSAKEFHDPLIYIESVR
AQVEKFGMCRVIPPPDWRPECKLNDEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLKSQGITMDELPLIGGCELDLACFFRLINEMGGM
QQVTDLKKWNKLADMLRIPRTAQDRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGPLEGHTENDHHKFHPLPRFEPKN
GLIHGVAPRNGFRSKLKEVGQAQLKTGRRRLFAQEKEVVKEEEEDKGVLNDFHKCIYKGRSVSLTTFYRTARNIMSMCFSKEPAPAEIEQ
EYWRLVEEKDCHVAVHCGKVDTNTHGSGFPVGKSEPFSRHGWNLTVLPNNTGSILRHLGAVPGVTIPWLNIGMVFSTSCWSRDQNHLPYI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDKAL1-JARID2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDKAL1-JARID2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDKAL1-JARID2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDKAL1C0011860Diabetes Mellitus, Non-Insulin-Dependent3CTD_human
HgeneCDKAL1C0005910Body Weight2CTD_human
HgeneCDKAL1C0005612Birth Weight1CTD_human
HgeneCDKAL1C0263859Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome1CTD_human
TgeneJARID2C0036341Schizophrenia2PSYGENET
TgeneJARID2C1510586Autism Spectrum Disorders1CTD_human