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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDYL2-DYNLRB2 (FusionGDB2 ID:15534)

Fusion Gene Summary for CDYL2-DYNLRB2

check button Fusion gene summary
Fusion gene informationFusion gene name: CDYL2-DYNLRB2
Fusion gene ID: 15534
HgeneTgene
Gene symbol

CDYL2

DYNLRB2

Gene ID

124359

83657

Gene namechromodomain Y like 2dynein light chain roadblock-type 2
SynonymsPCCP1DNCL2B|DNLC2B|ROBLD2
Cytomap

16q23.2

16q23.2

Type of geneprotein-codingprotein-coding
Descriptionchromodomain Y-like protein 2CDY-like 2chromodomain protein, Y-like 2prostate cancer candidate protein 1, PCCP1dynein light chain roadblock-type 2bithoraxoid-like proteindynein light chain 2B, cytoplasmicdynein, cytoplasmic, light polypeptide 2Broadblock domain-containing protein 2testicular tissue protein Li 53
Modification date2020031820200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000570137, ENST00000562812, 
ENST00000566173, ENST00000563890, 
ENST00000562753, 		ENST00000562982, 
ENST00000305904, ENST00000568035, 
ENST00000570222, 
Fusion gene scores* DoF score7 X 7 X 3=1473 X 2 X 3=18
# samples 93
** MAII scorelog2(9/147*10)=-0.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDYL2 [Title/Abstract] AND DYNLRB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDYL2(80838047)-DYNLRB2(80577173), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CDYL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DYNLRB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-8264-01BCDYL2chr16

80838047

-DYNLRB2chr16

80577173

+


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Fusion Gene ORF analysis for CDYL2-DYNLRB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000570137ENST00000562982CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
In-frameENST00000570137ENST00000305904CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
In-frameENST00000570137ENST00000568035CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
5CDS-intronENST00000570137ENST00000570222CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
In-frameENST00000562812ENST00000562982CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
In-frameENST00000562812ENST00000305904CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
In-frameENST00000562812ENST00000568035CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
5CDS-intronENST00000562812ENST00000570222CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
In-frameENST00000566173ENST00000562982CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
In-frameENST00000566173ENST00000305904CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
In-frameENST00000566173ENST00000568035CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
5CDS-intronENST00000566173ENST00000570222CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
In-frameENST00000563890ENST00000562982CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
In-frameENST00000563890ENST00000305904CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
In-frameENST00000563890ENST00000568035CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
5CDS-intronENST00000563890ENST00000570222CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
intron-3CDSENST00000562753ENST00000562982CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
intron-3CDSENST00000562753ENST00000305904CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
intron-3CDSENST00000562753ENST00000568035CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+
intron-intronENST00000562753ENST00000570222CDYL2chr16

80838047

-DYNLRB2chr16

80577173

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000570137CDYL2chr1680838047-ENST00000562982DYNLRB2chr1680577173+5511800467155
ENST00000570137CDYL2chr1680838047-ENST00000305904DYNLRB2chr1680577173+5541800467155
ENST00000570137CDYL2chr1680838047-ENST00000568035DYNLRB2chr1680577173+502180029999
ENST00000562812CDYL2chr1680838047-ENST00000562982DYNLRB2chr1680577173+48511490401103
ENST00000562812CDYL2chr1680838047-ENST00000305904DYNLRB2chr1680577173+48811490401103
ENST00000562812CDYL2chr1680838047-ENST00000568035DYNLRB2chr1680577173+4361149023347
ENST00000566173CDYL2chr1680838047-ENST00000562982DYNLRB2chr1680577173+48511490401103
ENST00000566173CDYL2chr1680838047-ENST00000305904DYNLRB2chr1680577173+48811490401103
ENST00000566173CDYL2chr1680838047-ENST00000568035DYNLRB2chr1680577173+4361149023347
ENST00000563890CDYL2chr1680838047-ENST00000562982DYNLRB2chr1680577173+48511490401103
ENST00000563890CDYL2chr1680838047-ENST00000305904DYNLRB2chr1680577173+48811490401103
ENST00000563890CDYL2chr1680838047-ENST00000568035DYNLRB2chr1680577173+4361149023347

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000570137ENST00000562982CDYL2chr1680838047-DYNLRB2chr1680577173+0.0230770370.976923
ENST00000570137ENST00000305904CDYL2chr1680838047-DYNLRB2chr1680577173+0.024195970.9758041
ENST00000570137ENST00000568035CDYL2chr1680838047-DYNLRB2chr1680577173+0.6133980.38660198
ENST00000562812ENST00000562982CDYL2chr1680838047-DYNLRB2chr1680577173+0.0200959630.97990406
ENST00000562812ENST00000305904CDYL2chr1680838047-DYNLRB2chr1680577173+0.0213681940.97863185
ENST00000562812ENST00000568035CDYL2chr1680838047-DYNLRB2chr1680577173+0.5543220.44567803
ENST00000566173ENST00000562982CDYL2chr1680838047-DYNLRB2chr1680577173+0.0200959630.97990406
ENST00000566173ENST00000305904CDYL2chr1680838047-DYNLRB2chr1680577173+0.0213681940.97863185
ENST00000566173ENST00000568035CDYL2chr1680838047-DYNLRB2chr1680577173+0.5543220.44567803
ENST00000563890ENST00000562982CDYL2chr1680838047-DYNLRB2chr1680577173+0.0200959630.97990406
ENST00000563890ENST00000305904CDYL2chr1680838047-DYNLRB2chr1680577173+0.0213681940.97863185
ENST00000563890ENST00000568035CDYL2chr1680838047-DYNLRB2chr1680577173+0.5543220.44567803

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Fusion Genomic Features for CDYL2-DYNLRB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDYL2chr1680838046-DYNLRB2chr1680577172+0.0005732420.99942684
CDYL2chr1680838046-DYNLRB2chr1680577172+0.0005732420.99942684

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDYL2-DYNLRB2


check button Go to

FGviewer for the breakpoints of chr16:80838047-chr16:80577173

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDYL2chr16:80838047chr16:80577173ENST00000570137-177_678.0507.0DomainChromo


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Fusion Gene Sequence for CDYL2-DYNLRB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000570137_ENST00000562982_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(transcript)=551nt_BP=180nt
CTGTCATTCTGCAAAAACACAGTTTACTCAACACACCACACACACTCGCACACACACGCGCGCACACACACGCGCACACCGGACCCCGCG
CGCACACGCACGGAGGGCGCGAGCGAGCAGACGCGCACACCGGCGAGCCAAGTTCCGCAGCCTGGCATGGCTTCTGGGGACCTTTACGAG
GCAGAGGTGGAGGAAACCTTAAAGAGGATCCAGAGTCATAAAGGGGTTATTGGAACTATGGTTGTAAATGCAGAAGGTATTCCCATCCGA
ACAACCTTGGACAACTCAACAACTGTTCAATATGCAGGCCTTCTTCATCACCTGACAATGAAAGCCAAAAGCACAGTTCGTGATATTGAT
CCTCAGAACGACCTGACTTTTCTTAGGATCAGATCAAAGAAACATGAAATCATGGTAGCTCCAGATAAGGAATATCTTCTGATCGTCATT
CAGAATCCATGTGAATAGACCTGCGATGGCCAAGGCTGTTTAAGCGACACTGGGTTGGAAACACTTGGCTCTCTCATGAGTATTAAAATT

>In-frame_ENST00000570137_ENST00000562982_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(amino acids)=155AA_start in transcript=0_stop in transcript=467
LSFCKNTVYSTHHTHSHTHARTHTRTPDPARTRTEGASEQTRTPASQVPQPGMASGDLYEAEVEETLKRIQSHKGVIGTMVVNAEGIPIR

--------------------------------------------------------------
>In-frame_ENST00000570137_ENST00000305904_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(transcript)=554nt_BP=180nt
CTGTCATTCTGCAAAAACACAGTTTACTCAACACACCACACACACTCGCACACACACGCGCGCACACACACGCGCACACCGGACCCCGCG
CGCACACGCACGGAGGGCGCGAGCGAGCAGACGCGCACACCGGCGAGCCAAGTTCCGCAGCCTGGCATGGCTTCTGGGGACCTTTACGAG
GCAGAGGTGGAGGAAACCTTAAAGAGGATCCAGAGTCATAAAGGGGTTATTGGAACTATGGTTGTAAATGCAGAAGGTATTCCCATCCGA
ACAACCTTGGACAACTCAACAACTGTTCAATATGCAGGCCTTCTTCATCACCTGACAATGAAAGCCAAAAGCACAGTTCGTGATATTGAT
CCTCAGAACGACCTGACTTTTCTTAGGATCAGATCAAAGAAACATGAAATCATGGTAGCTCCAGATAAGGAATATCTTCTGATCGTCATT
CAGAATCCATGTGAATAGACCTGCGATGGCCAAGGCTGTTTAAGCGACACTGGGTTGGAAACACTTGGCTCTCTCATGAGTATTAAAATT

>In-frame_ENST00000570137_ENST00000305904_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(amino acids)=155AA_start in transcript=0_stop in transcript=467
LSFCKNTVYSTHHTHSHTHARTHTRTPDPARTRTEGASEQTRTPASQVPQPGMASGDLYEAEVEETLKRIQSHKGVIGTMVVNAEGIPIR

--------------------------------------------------------------
>In-frame_ENST00000570137_ENST00000568035_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(transcript)=502nt_BP=180nt
CTGTCATTCTGCAAAAACACAGTTTACTCAACACACCACACACACTCGCACACACACGCGCGCACACACACGCGCACACCGGACCCCGCG
CGCACACGCACGGAGGGCGCGAGCGAGCAGACGCGCACACCGGCGAGCCAAGTTCCGCAGCCTGGCATGGCTTCTGGGGACCTTTACGAG
GCAGAGGTGGAGGAAACCTTAAAGAGGATCCAGAGTCATAAAGGGGTTATTGGAACTATGGTTGTAAATGCAGAAGATAAGGAATATCTT
CTGATCGTCATTCAGAATCCATGTGAATAGACCTGCGATGGCCAAGGCTGTTTAAGCGACACTGGGTTGGAAACACTTGGCTCTCTCATG
AGTATTAAAATTCTATTTCAATCTAACTGACCCTTCAAACATTCTTTTCTATTTCTATATCTAAACTGTTCTGCATGTCTCATTTAGTCC

>In-frame_ENST00000570137_ENST00000568035_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(amino acids)=99AA_start in transcript=0_stop in transcript=299
LSFCKNTVYSTHHTHSHTHARTHTRTPDPARTRTEGASEQTRTPASQVPQPGMASGDLYEAEVEETLKRIQSHKGVIGTMVVNAEDKEYL

--------------------------------------------------------------
>In-frame_ENST00000562812_ENST00000562982_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(transcript)=485nt_BP=114nt
CACACGCGCACACCGGACCCCGCGCGCACACGCACGGAGGGCGCGAGCGAGCAGACGCGCACACCGGCGAGCCAAGTTCCGCAGCCTGGC
ATGGCTTCTGGGGACCTTTACGAGGCAGAGGTGGAGGAAACCTTAAAGAGGATCCAGAGTCATAAAGGGGTTATTGGAACTATGGTTGTA
AATGCAGAAGGTATTCCCATCCGAACAACCTTGGACAACTCAACAACTGTTCAATATGCAGGCCTTCTTCATCACCTGACAATGAAAGCC
AAAAGCACAGTTCGTGATATTGATCCTCAGAACGACCTGACTTTTCTTAGGATCAGATCAAAGAAACATGAAATCATGGTAGCTCCAGAT
AAGGAATATCTTCTGATCGTCATTCAGAATCCATGTGAATAGACCTGCGATGGCCAAGGCTGTTTAAGCGACACTGGGTTGGAAACACTT

>In-frame_ENST00000562812_ENST00000562982_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(amino acids)=103AA_start in transcript=90_stop in transcript=401
MASGDLYEAEVEETLKRIQSHKGVIGTMVVNAEGIPIRTTLDNSTTVQYAGLLHHLTMKAKSTVRDIDPQNDLTFLRIRSKKHEIMVAPD

--------------------------------------------------------------
>In-frame_ENST00000562812_ENST00000305904_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(transcript)=488nt_BP=114nt
CACACGCGCACACCGGACCCCGCGCGCACACGCACGGAGGGCGCGAGCGAGCAGACGCGCACACCGGCGAGCCAAGTTCCGCAGCCTGGC
ATGGCTTCTGGGGACCTTTACGAGGCAGAGGTGGAGGAAACCTTAAAGAGGATCCAGAGTCATAAAGGGGTTATTGGAACTATGGTTGTA
AATGCAGAAGGTATTCCCATCCGAACAACCTTGGACAACTCAACAACTGTTCAATATGCAGGCCTTCTTCATCACCTGACAATGAAAGCC
AAAAGCACAGTTCGTGATATTGATCCTCAGAACGACCTGACTTTTCTTAGGATCAGATCAAAGAAACATGAAATCATGGTAGCTCCAGAT
AAGGAATATCTTCTGATCGTCATTCAGAATCCATGTGAATAGACCTGCGATGGCCAAGGCTGTTTAAGCGACACTGGGTTGGAAACACTT

>In-frame_ENST00000562812_ENST00000305904_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(amino acids)=103AA_start in transcript=90_stop in transcript=401
MASGDLYEAEVEETLKRIQSHKGVIGTMVVNAEGIPIRTTLDNSTTVQYAGLLHHLTMKAKSTVRDIDPQNDLTFLRIRSKKHEIMVAPD

--------------------------------------------------------------
>In-frame_ENST00000562812_ENST00000568035_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(transcript)=436nt_BP=114nt
CACACGCGCACACCGGACCCCGCGCGCACACGCACGGAGGGCGCGAGCGAGCAGACGCGCACACCGGCGAGCCAAGTTCCGCAGCCTGGC
ATGGCTTCTGGGGACCTTTACGAGGCAGAGGTGGAGGAAACCTTAAAGAGGATCCAGAGTCATAAAGGGGTTATTGGAACTATGGTTGTA
AATGCAGAAGATAAGGAATATCTTCTGATCGTCATTCAGAATCCATGTGAATAGACCTGCGATGGCCAAGGCTGTTTAAGCGACACTGGG
TTGGAAACACTTGGCTCTCTCATGAGTATTAAAATTCTATTTCAATCTAACTGACCCTTCAAACATTCTTTTCTATTTCTATATCTAAAC

>In-frame_ENST00000562812_ENST00000568035_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(amino acids)=47AA_start in transcript=90_stop in transcript=233

--------------------------------------------------------------
>In-frame_ENST00000566173_ENST00000562982_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(transcript)=485nt_BP=114nt
CACACGCGCACACCGGACCCCGCGCGCACACGCACGGAGGGCGCGAGCGAGCAGACGCGCACACCGGCGAGCCAAGTTCCGCAGCCTGGC
ATGGCTTCTGGGGACCTTTACGAGGCAGAGGTGGAGGAAACCTTAAAGAGGATCCAGAGTCATAAAGGGGTTATTGGAACTATGGTTGTA
AATGCAGAAGGTATTCCCATCCGAACAACCTTGGACAACTCAACAACTGTTCAATATGCAGGCCTTCTTCATCACCTGACAATGAAAGCC
AAAAGCACAGTTCGTGATATTGATCCTCAGAACGACCTGACTTTTCTTAGGATCAGATCAAAGAAACATGAAATCATGGTAGCTCCAGAT
AAGGAATATCTTCTGATCGTCATTCAGAATCCATGTGAATAGACCTGCGATGGCCAAGGCTGTTTAAGCGACACTGGGTTGGAAACACTT

>In-frame_ENST00000566173_ENST00000562982_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(amino acids)=103AA_start in transcript=90_stop in transcript=401
MASGDLYEAEVEETLKRIQSHKGVIGTMVVNAEGIPIRTTLDNSTTVQYAGLLHHLTMKAKSTVRDIDPQNDLTFLRIRSKKHEIMVAPD

--------------------------------------------------------------
>In-frame_ENST00000566173_ENST00000305904_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(transcript)=488nt_BP=114nt
CACACGCGCACACCGGACCCCGCGCGCACACGCACGGAGGGCGCGAGCGAGCAGACGCGCACACCGGCGAGCCAAGTTCCGCAGCCTGGC
ATGGCTTCTGGGGACCTTTACGAGGCAGAGGTGGAGGAAACCTTAAAGAGGATCCAGAGTCATAAAGGGGTTATTGGAACTATGGTTGTA
AATGCAGAAGGTATTCCCATCCGAACAACCTTGGACAACTCAACAACTGTTCAATATGCAGGCCTTCTTCATCACCTGACAATGAAAGCC
AAAAGCACAGTTCGTGATATTGATCCTCAGAACGACCTGACTTTTCTTAGGATCAGATCAAAGAAACATGAAATCATGGTAGCTCCAGAT
AAGGAATATCTTCTGATCGTCATTCAGAATCCATGTGAATAGACCTGCGATGGCCAAGGCTGTTTAAGCGACACTGGGTTGGAAACACTT

>In-frame_ENST00000566173_ENST00000305904_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(amino acids)=103AA_start in transcript=90_stop in transcript=401
MASGDLYEAEVEETLKRIQSHKGVIGTMVVNAEGIPIRTTLDNSTTVQYAGLLHHLTMKAKSTVRDIDPQNDLTFLRIRSKKHEIMVAPD

--------------------------------------------------------------
>In-frame_ENST00000566173_ENST00000568035_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(transcript)=436nt_BP=114nt
CACACGCGCACACCGGACCCCGCGCGCACACGCACGGAGGGCGCGAGCGAGCAGACGCGCACACCGGCGAGCCAAGTTCCGCAGCCTGGC
ATGGCTTCTGGGGACCTTTACGAGGCAGAGGTGGAGGAAACCTTAAAGAGGATCCAGAGTCATAAAGGGGTTATTGGAACTATGGTTGTA
AATGCAGAAGATAAGGAATATCTTCTGATCGTCATTCAGAATCCATGTGAATAGACCTGCGATGGCCAAGGCTGTTTAAGCGACACTGGG
TTGGAAACACTTGGCTCTCTCATGAGTATTAAAATTCTATTTCAATCTAACTGACCCTTCAAACATTCTTTTCTATTTCTATATCTAAAC

>In-frame_ENST00000566173_ENST00000568035_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(amino acids)=47AA_start in transcript=90_stop in transcript=233

--------------------------------------------------------------
>In-frame_ENST00000563890_ENST00000562982_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(transcript)=485nt_BP=114nt
CACACGCGCACACCGGACCCCGCGCGCACACGCACGGAGGGCGCGAGCGAGCAGACGCGCACACCGGCGAGCCAAGTTCCGCAGCCTGGC
ATGGCTTCTGGGGACCTTTACGAGGCAGAGGTGGAGGAAACCTTAAAGAGGATCCAGAGTCATAAAGGGGTTATTGGAACTATGGTTGTA
AATGCAGAAGGTATTCCCATCCGAACAACCTTGGACAACTCAACAACTGTTCAATATGCAGGCCTTCTTCATCACCTGACAATGAAAGCC
AAAAGCACAGTTCGTGATATTGATCCTCAGAACGACCTGACTTTTCTTAGGATCAGATCAAAGAAACATGAAATCATGGTAGCTCCAGAT
AAGGAATATCTTCTGATCGTCATTCAGAATCCATGTGAATAGACCTGCGATGGCCAAGGCTGTTTAAGCGACACTGGGTTGGAAACACTT

>In-frame_ENST00000563890_ENST00000562982_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(amino acids)=103AA_start in transcript=90_stop in transcript=401
MASGDLYEAEVEETLKRIQSHKGVIGTMVVNAEGIPIRTTLDNSTTVQYAGLLHHLTMKAKSTVRDIDPQNDLTFLRIRSKKHEIMVAPD

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>In-frame_ENST00000563890_ENST00000305904_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(transcript)=488nt_BP=114nt
CACACGCGCACACCGGACCCCGCGCGCACACGCACGGAGGGCGCGAGCGAGCAGACGCGCACACCGGCGAGCCAAGTTCCGCAGCCTGGC
ATGGCTTCTGGGGACCTTTACGAGGCAGAGGTGGAGGAAACCTTAAAGAGGATCCAGAGTCATAAAGGGGTTATTGGAACTATGGTTGTA
AATGCAGAAGGTATTCCCATCCGAACAACCTTGGACAACTCAACAACTGTTCAATATGCAGGCCTTCTTCATCACCTGACAATGAAAGCC
AAAAGCACAGTTCGTGATATTGATCCTCAGAACGACCTGACTTTTCTTAGGATCAGATCAAAGAAACATGAAATCATGGTAGCTCCAGAT
AAGGAATATCTTCTGATCGTCATTCAGAATCCATGTGAATAGACCTGCGATGGCCAAGGCTGTTTAAGCGACACTGGGTTGGAAACACTT

>In-frame_ENST00000563890_ENST00000305904_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(amino acids)=103AA_start in transcript=90_stop in transcript=401
MASGDLYEAEVEETLKRIQSHKGVIGTMVVNAEGIPIRTTLDNSTTVQYAGLLHHLTMKAKSTVRDIDPQNDLTFLRIRSKKHEIMVAPD

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>In-frame_ENST00000563890_ENST00000568035_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(transcript)=436nt_BP=114nt
CACACGCGCACACCGGACCCCGCGCGCACACGCACGGAGGGCGCGAGCGAGCAGACGCGCACACCGGCGAGCCAAGTTCCGCAGCCTGGC
ATGGCTTCTGGGGACCTTTACGAGGCAGAGGTGGAGGAAACCTTAAAGAGGATCCAGAGTCATAAAGGGGTTATTGGAACTATGGTTGTA
AATGCAGAAGATAAGGAATATCTTCTGATCGTCATTCAGAATCCATGTGAATAGACCTGCGATGGCCAAGGCTGTTTAAGCGACACTGGG
TTGGAAACACTTGGCTCTCTCATGAGTATTAAAATTCTATTTCAATCTAACTGACCCTTCAAACATTCTTTTCTATTTCTATATCTAAAC

>In-frame_ENST00000563890_ENST00000568035_TCGA-HC-8264-01B_CDYL2_chr16_80838047_-_DYNLRB2_chr16_80577173_length(amino acids)=47AA_start in transcript=90_stop in transcript=233

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Fusion Gene PPI Analysis for CDYL2-DYNLRB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDYL2-DYNLRB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDYL2-DYNLRB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource