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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CENPT-RPL14 (FusionGDB2 ID:15773)

Fusion Gene Summary for CENPT-RPL14

check button Fusion gene summary
Fusion gene informationFusion gene name: CENPT-RPL14
Fusion gene ID: 15773
HgeneTgene
Gene symbol

CENPT

RPL14

Gene ID

80152

9045

Gene namecentromere protein Tribosomal protein L14
SynonymsC16orf56|CENP-T|SSMGACAG-ISL-7|CTG-B33|L14|RL14|hRL14
Cytomap

16q22.1

3p22.1

Type of geneprotein-codingprotein-coding
Descriptioncentromere protein Tinterphase centromere complex protein 2260S ribosomal protein L14large ribosomal subunit protein eL14
Modification date2020032020200313
UniProtAcc

Q96BT3

.
Ensembl transtripts involved in fusion geneENST00000562787, ENST00000440851, 
ENST00000219172, ENST00000564817, 
ENST00000562947, ENST00000445712, 
ENST00000338970, ENST00000396203, 
ENST00000416518, ENST00000461368, 
Fusion gene scores* DoF score4 X 5 X 3=6016 X 21 X 11=3696
# samples 529
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/3696*10)=-3.67183995140112
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CENPT [Title/Abstract] AND RPL14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCENPT(67876834)-RPL14(40503553), # samples:1
CENPT(67876840)-RPL14(40503553), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CENPT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RPL14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-37-3789CENPTchr16

67876834

-RPL14chr3

40503553

+
ChimerDB4UCECTCGA-D1-A162-01ACENPTchr16

67876840

-RPL14chr3

40503553

+


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Fusion Gene ORF analysis for CENPT-RPL14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000562787ENST00000338970CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3CDSENST00000562787ENST00000396203CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3UTRENST00000562787ENST00000416518CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-intronENST00000562787ENST00000461368CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3CDSENST00000440851ENST00000338970CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3CDSENST00000440851ENST00000396203CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3UTRENST00000440851ENST00000416518CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-intronENST00000440851ENST00000461368CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3CDSENST00000219172ENST00000338970CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3CDSENST00000219172ENST00000396203CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3UTRENST00000219172ENST00000416518CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-intronENST00000219172ENST00000461368CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3CDSENST00000564817ENST00000338970CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3CDSENST00000564817ENST00000396203CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3UTRENST00000564817ENST00000416518CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-intronENST00000564817ENST00000461368CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3CDSENST00000562947ENST00000338970CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3CDSENST00000562947ENST00000396203CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3UTRENST00000562947ENST00000416518CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-intronENST00000562947ENST00000461368CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3CDSENST00000445712ENST00000338970CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3CDSENST00000445712ENST00000396203CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3UTRENST00000445712ENST00000416518CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-intronENST00000445712ENST00000461368CENPTchr16

67876834

-RPL14chr3

40503553

+
intron-3CDSENST00000562787ENST00000338970CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3CDSENST00000562787ENST00000396203CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3UTRENST00000562787ENST00000416518CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-intronENST00000562787ENST00000461368CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3CDSENST00000440851ENST00000338970CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3CDSENST00000440851ENST00000396203CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3UTRENST00000440851ENST00000416518CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-intronENST00000440851ENST00000461368CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3CDSENST00000219172ENST00000338970CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3CDSENST00000219172ENST00000396203CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3UTRENST00000219172ENST00000416518CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-intronENST00000219172ENST00000461368CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3CDSENST00000564817ENST00000338970CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3CDSENST00000564817ENST00000396203CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3UTRENST00000564817ENST00000416518CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-intronENST00000564817ENST00000461368CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3CDSENST00000562947ENST00000338970CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3CDSENST00000562947ENST00000396203CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3UTRENST00000562947ENST00000416518CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-intronENST00000562947ENST00000461368CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3CDSENST00000445712ENST00000338970CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3CDSENST00000445712ENST00000396203CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-3UTRENST00000445712ENST00000416518CENPTchr16

67876840

-RPL14chr3

40503553

+
intron-intronENST00000445712ENST00000461368CENPTchr16

67876840

-RPL14chr3

40503553

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CENPT-RPL14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CENPT-RPL14


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CENPT

Q96BT3

.
FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CENPT-RPL14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CENPT-RPL14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CENPT-RPL14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CENPT-RPL14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRPL14C0007134Renal Cell Carcinoma1CTD_human
TgeneRPL14C0030567Parkinson Disease1CTD_human
TgeneRPL14C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneRPL14C1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneRPL14C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneRPL14C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneRPL14C1306837Papillary Renal Cell Carcinoma1CTD_human