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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CEP170-XRN2 (FusionGDB2 ID:15840)

Fusion Gene Summary for CEP170-XRN2

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP170-XRN2
Fusion gene ID: 15840
HgeneTgene
Gene symbol

CEP170

XRN2

Gene ID

9859

22803

Gene namecentrosomal protein 1705'-3' exoribonuclease 2
SynonymsFAM68A|KAB|KIAA0470-
Cytomap

1q43

20p11.22

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 170 kDaKARP-1-binding proteinXRCC5 binding proteincentrosomal protein 170kDa5'-3' exoribonuclease 2DHP proteinDhm1-like protein
Modification date2020031320200313
UniProtAcc

Q5SW79

.
Ensembl transtripts involved in fusion geneENST00000366542, ENST00000366543, 
ENST00000366544, ENST00000468254, 
ENST00000481987, ENST00000490813, 
ENST00000377191, ENST00000430571, 
ENST00000539513, 
Fusion gene scores* DoF score12 X 9 X 10=108012 X 12 X 5=720
# samples 1312
** MAII scorelog2(13/1080*10)=-3.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP170 [Title/Abstract] AND XRN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCEP170(243362361)-XRN2(21362631), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneXRN2

GO:0000738

DNA catabolic process, exonucleolytic

15565158


check buttonFusion gene breakpoints across CEP170 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across XRN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BR-6852-11ACEP170chr1

243362361

-XRN2chr20

21362631

+


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Fusion Gene ORF analysis for CEP170-XRN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000366542ENST00000377191CEP170chr1

243362361

-XRN2chr20

21362631

+
In-frameENST00000366542ENST00000430571CEP170chr1

243362361

-XRN2chr20

21362631

+
In-frameENST00000366542ENST00000539513CEP170chr1

243362361

-XRN2chr20

21362631

+
In-frameENST00000366543ENST00000377191CEP170chr1

243362361

-XRN2chr20

21362631

+
In-frameENST00000366543ENST00000430571CEP170chr1

243362361

-XRN2chr20

21362631

+
In-frameENST00000366543ENST00000539513CEP170chr1

243362361

-XRN2chr20

21362631

+
In-frameENST00000366544ENST00000377191CEP170chr1

243362361

-XRN2chr20

21362631

+
In-frameENST00000366544ENST00000430571CEP170chr1

243362361

-XRN2chr20

21362631

+
In-frameENST00000366544ENST00000539513CEP170chr1

243362361

-XRN2chr20

21362631

+
intron-3CDSENST00000468254ENST00000377191CEP170chr1

243362361

-XRN2chr20

21362631

+
intron-3CDSENST00000468254ENST00000430571CEP170chr1

243362361

-XRN2chr20

21362631

+
intron-3CDSENST00000468254ENST00000539513CEP170chr1

243362361

-XRN2chr20

21362631

+
intron-3CDSENST00000481987ENST00000377191CEP170chr1

243362361

-XRN2chr20

21362631

+
intron-3CDSENST00000481987ENST00000430571CEP170chr1

243362361

-XRN2chr20

21362631

+
intron-3CDSENST00000481987ENST00000539513CEP170chr1

243362361

-XRN2chr20

21362631

+
intron-3CDSENST00000490813ENST00000377191CEP170chr1

243362361

-XRN2chr20

21362631

+
intron-3CDSENST00000490813ENST00000430571CEP170chr1

243362361

-XRN2chr20

21362631

+
intron-3CDSENST00000490813ENST00000539513CEP170chr1

243362361

-XRN2chr20

21362631

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366542CEP170chr1243362361-ENST00000377191XRN2chr2021362631+143968352951299
ENST00000366542CEP170chr1243362361-ENST00000430571XRN2chr2021362631+123968352951299
ENST00000366542CEP170chr1243362361-ENST00000539513XRN2chr2021362631+143968352951299
ENST00000366543CEP170chr1243362361-ENST00000377191XRN2chr2021362631+17109543231222299
ENST00000366543CEP170chr1243362361-ENST00000430571XRN2chr2021362631+15109543231222299
ENST00000366543CEP170chr1243362361-ENST00000539513XRN2chr2021362631+17109543231222299
ENST00000366544CEP170chr1243362361-ENST00000377191XRN2chr2021362631+17109543231222299
ENST00000366544CEP170chr1243362361-ENST00000430571XRN2chr2021362631+15109543231222299
ENST00000366544CEP170chr1243362361-ENST00000539513XRN2chr2021362631+17109543231222299

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366542ENST00000377191CEP170chr1243362361-XRN2chr2021362631+0.002545260.9974547
ENST00000366542ENST00000430571CEP170chr1243362361-XRN2chr2021362631+0.0033549050.99664503
ENST00000366542ENST00000539513CEP170chr1243362361-XRN2chr2021362631+0.002545260.9974547
ENST00000366543ENST00000377191CEP170chr1243362361-XRN2chr2021362631+0.001870470.99812955
ENST00000366543ENST00000430571CEP170chr1243362361-XRN2chr2021362631+0.0024948120.99750525
ENST00000366543ENST00000539513CEP170chr1243362361-XRN2chr2021362631+0.001870470.99812955
ENST00000366544ENST00000377191CEP170chr1243362361-XRN2chr2021362631+0.001870470.99812955
ENST00000366544ENST00000430571CEP170chr1243362361-XRN2chr2021362631+0.0024948120.99750525
ENST00000366544ENST00000539513CEP170chr1243362361-XRN2chr2021362631+0.001870470.99812955

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Fusion Genomic Features for CEP170-XRN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CEP170chr1243362361-XRN2chr2021362631+3.93E-050.99996066
CEP170chr1243362361-XRN2chr2021362631+3.93E-050.99996066

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CEP170-XRN2


check button Go to

FGviewer for the breakpoints of chr1:243362361-chr20:21362631

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP170

Q5SW79

.
FUNCTION: Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP170chr1:243362361chr20:21362631ENST00000366542-72023_73210.333333333333341585.0DomainFHA
HgeneCEP170chr1:243362361chr20:21362631ENST00000366543-71923_73210.333333333333341461.0DomainFHA
HgeneCEP170chr1:243362361chr20:21362631ENST00000366544-71923_73210.333333333333341487.0DomainFHA

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP170chr1:243362361chr20:21362631ENST00000366542-7201467_1495210.333333333333341585.0Coiled coilOntology_term=ECO:0000255
HgeneCEP170chr1:243362361chr20:21362631ENST00000366543-7191467_1495210.333333333333341461.0Coiled coilOntology_term=ECO:0000255
HgeneCEP170chr1:243362361chr20:21362631ENST00000366544-7191467_1495210.333333333333341487.0Coiled coilOntology_term=ECO:0000255
HgeneCEP170chr1:243362361chr20:21362631ENST00000366542-7201113_1584210.333333333333341585.0RegionNote=Targeting to centrosomes
HgeneCEP170chr1:243362361chr20:21362631ENST00000366542-720853_1584210.333333333333341585.0RegionNote=Targeting to microtubules
HgeneCEP170chr1:243362361chr20:21362631ENST00000366543-7191113_1584210.333333333333341461.0RegionNote=Targeting to centrosomes
HgeneCEP170chr1:243362361chr20:21362631ENST00000366543-719853_1584210.333333333333341461.0RegionNote=Targeting to microtubules
HgeneCEP170chr1:243362361chr20:21362631ENST00000366544-7191113_1584210.333333333333341487.0RegionNote=Targeting to centrosomes
HgeneCEP170chr1:243362361chr20:21362631ENST00000366544-719853_1584210.333333333333341487.0RegionNote=Targeting to microtubules
TgeneXRN2chr1:243362361chr20:21362631ENST000003771912630262_278861.3333333333334951.0Zinc fingerNote=CCHC-type
TgeneXRN2chr1:243362361chr20:21362631ENST000004305712529262_278785.3333333333334875.0Zinc fingerNote=CCHC-type


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Fusion Gene Sequence for CEP170-XRN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000366542_ENST00000377191_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(transcript)=1439nt_BP=683nt
CACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAGG
CACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAACA
CGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGACTTTTGTGAATGATGTAAGGAT
TCCGGAACAGACTTATATCACCTTGAAACTTGAAGATAAGCTGAGATTTGGATATGATACAAATCTTTTCACTGTAGTACAAGGAGAAAT
GAGGGTCCCTGAAGAAGCTCTTAAGCATGAGAAGTTTACCATTCAGCTTCAGTTGTCCCAAAAATCTTCAGAATCAGAATTATCCAAATC
TGCAAGTGCCAAAAGCATAGATTCAAAGGTAGCAGACGCTGCTACTGAAGTGCAGCACAAAACTACTGAAGCACTGAAATCCGAGGAAAA
AGCCATGGATATTTCTGCTATGCCCCGTGGTACTCCATTATATGGGCAGCCGTCATGGTGGGGGGATGATGAGGTGGATGAAAAAAGAGC
TTTCAAGACAAATGGCAAACCTGAAGAAAAAAACCATGAAGCTGGAACATCAGATATGAGGCCCCAGGATTCCTGGCGAGGTCCTCCTCC
CCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAACCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGCAGCCTT
CCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTATCCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCCCAGAGA
AGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAATTGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATCATTCTA
CAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTAGTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAACTGTGTA
TATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAAGATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTGCTTATA
AAACACATTTGATGGAATAGGAGTACTGGTTTTTCATAATGGTTAAAAATGAAACCAGCTGTGGATTTCAAAACACAGTGTATTCTAGAT
CATCTAAGATCCATGCTGATTTTTATTGCACAAGAATTAGGTTTGAACTCGAGCTGGAACCTCAGCAAACTAGAGTATATATTGTTCAGT

>In-frame_ENST00000366542_ENST00000377191_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(amino acids)=299AA_start in transcript=52_stop in transcript=951
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSDMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPR

--------------------------------------------------------------
>In-frame_ENST00000366542_ENST00000430571_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(transcript)=1239nt_BP=683nt
CACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAGG
CACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAACA
CGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGACTTTTGTGAATGATGTAAGGAT
TCCGGAACAGACTTATATCACCTTGAAACTTGAAGATAAGCTGAGATTTGGATATGATACAAATCTTTTCACTGTAGTACAAGGAGAAAT
GAGGGTCCCTGAAGAAGCTCTTAAGCATGAGAAGTTTACCATTCAGCTTCAGTTGTCCCAAAAATCTTCAGAATCAGAATTATCCAAATC
TGCAAGTGCCAAAAGCATAGATTCAAAGGTAGCAGACGCTGCTACTGAAGTGCAGCACAAAACTACTGAAGCACTGAAATCCGAGGAAAA
AGCCATGGATATTTCTGCTATGCCCCGTGGTACTCCATTATATGGGCAGCCGTCATGGTGGGGGGATGATGAGGTGGATGAAAAAAGAGC
TTTCAAGACAAATGGCAAACCTGAAGAAAAAAACCATGAAGCTGGAACATCAGATATGAGGCCCCAGGATTCCTGGCGAGGTCCTCCTCC
CCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAACCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGCAGCCTT
CCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTATCCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCCCAGAGA
AGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAATTGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATCATTCTA
CAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTAGTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAACTGTGTA
TATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAAGATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTGCTTATA

>In-frame_ENST00000366542_ENST00000430571_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(amino acids)=299AA_start in transcript=52_stop in transcript=951
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSDMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPR

--------------------------------------------------------------
>In-frame_ENST00000366542_ENST00000539513_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(transcript)=1439nt_BP=683nt
CACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAGG
CACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAACA
CGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGACTTTTGTGAATGATGTAAGGAT
TCCGGAACAGACTTATATCACCTTGAAACTTGAAGATAAGCTGAGATTTGGATATGATACAAATCTTTTCACTGTAGTACAAGGAGAAAT
GAGGGTCCCTGAAGAAGCTCTTAAGCATGAGAAGTTTACCATTCAGCTTCAGTTGTCCCAAAAATCTTCAGAATCAGAATTATCCAAATC
TGCAAGTGCCAAAAGCATAGATTCAAAGGTAGCAGACGCTGCTACTGAAGTGCAGCACAAAACTACTGAAGCACTGAAATCCGAGGAAAA
AGCCATGGATATTTCTGCTATGCCCCGTGGTACTCCATTATATGGGCAGCCGTCATGGTGGGGGGATGATGAGGTGGATGAAAAAAGAGC
TTTCAAGACAAATGGCAAACCTGAAGAAAAAAACCATGAAGCTGGAACATCAGATATGAGGCCCCAGGATTCCTGGCGAGGTCCTCCTCC
CCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAACCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGCAGCCTT
CCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTATCCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCCCAGAGA
AGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAATTGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATCATTCTA
CAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTAGTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAACTGTGTA
TATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAAGATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTGCTTATA
AAACACATTTGATGGAATAGGAGTACTGGTTTTTCATAATGGTTAAAAATGAAACCAGCTGTGGATTTCAAAACACAGTGTATTCTAGAT
CATCTAAGATCCATGCTGATTTTTATTGCACAAGAATTAGGTTTGAACTCGAGCTGGAACCTCAGCAAACTAGAGTATATATTGTTCAGT

>In-frame_ENST00000366542_ENST00000539513_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(amino acids)=299AA_start in transcript=52_stop in transcript=951
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSDMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPR

--------------------------------------------------------------
>In-frame_ENST00000366543_ENST00000377191_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(transcript)=1710nt_BP=954nt
TTGGAACTGGGCAGGAGGGGATAGGGTCCGGCTCCTCGCCCTTTCCCGAGGCGCCTGCGCACTAGGCAGTCGGTCTTTGCCGTTACCGCT
ATGTGTGGGGCGTGTGTGGAATAACGTTATTGCCCAGCGGAGCTGAGGGCCCCGGAGCTCGACCGCAGCGGCAGCGACGACAACAGCGGC
GACGACGACGACGACGAGGTGGGGGGAGGACGGCGTGCGAGAGACTCACGGGACGCGACGCGCCCCGCCTCCCCCGTCCGGTCCCTCTCT
CCACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAG
GCACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAAC
ACGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGACTTTTGTGAATGATGTAAGGA
TTCCGGAACAGACTTATATCACCTTGAAACTTGAAGATAAGCTGAGATTTGGATATGATACAAATCTTTTCACTGTAGTACAAGGAGAAA
TGAGGGTCCCTGAAGAAGCTCTTAAGCATGAGAAGTTTACCATTCAGCTTCAGTTGTCCCAAAAATCTTCAGAATCAGAATTATCCAAAT
CTGCAAGTGCCAAAAGCATAGATTCAAAGGTAGCAGACGCTGCTACTGAAGTGCAGCACAAAACTACTGAAGCACTGAAATCCGAGGAAA
AAGCCATGGATATTTCTGCTATGCCCCGTGGTACTCCATTATATGGGCAGCCGTCATGGTGGGGGGATGATGAGGTGGATGAAAAAAGAG
CTTTCAAGACAAATGGCAAACCTGAAGAAAAAAACCATGAAGCTGGAACATCAGATATGAGGCCCCAGGATTCCTGGCGAGGTCCTCCTC
CCCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAACCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGCAGCCT
TCCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTATCCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCCCAGAG
AAGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAATTGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATCATTCT
ACAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTAGTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAACTGTGT
ATATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAAGATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTGCTTAT
AAAACACATTTGATGGAATAGGAGTACTGGTTTTTCATAATGGTTAAAAATGAAACCAGCTGTGGATTTCAAAACACAGTGTATTCTAGA
TCATCTAAGATCCATGCTGATTTTTATTGCACAAGAATTAGGTTTGAACTCGAGCTGGAACCTCAGCAAACTAGAGTATATATTGTTCAG
TATTTCTTTGGAAACATTTCATTAATGTACTTGTCTTACAGAAATTTCTGAACTTTAGTAAAAAAAAATAAAGTTAAACTTTTAAAACTC

>In-frame_ENST00000366543_ENST00000377191_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(amino acids)=299AA_start in transcript=323_stop in transcript=1222
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSDMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPR

--------------------------------------------------------------
>In-frame_ENST00000366543_ENST00000430571_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(transcript)=1510nt_BP=954nt
TTGGAACTGGGCAGGAGGGGATAGGGTCCGGCTCCTCGCCCTTTCCCGAGGCGCCTGCGCACTAGGCAGTCGGTCTTTGCCGTTACCGCT
ATGTGTGGGGCGTGTGTGGAATAACGTTATTGCCCAGCGGAGCTGAGGGCCCCGGAGCTCGACCGCAGCGGCAGCGACGACAACAGCGGC
GACGACGACGACGACGAGGTGGGGGGAGGACGGCGTGCGAGAGACTCACGGGACGCGACGCGCCCCGCCTCCCCCGTCCGGTCCCTCTCT
CCACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAG
GCACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAAC
ACGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGACTTTTGTGAATGATGTAAGGA
TTCCGGAACAGACTTATATCACCTTGAAACTTGAAGATAAGCTGAGATTTGGATATGATACAAATCTTTTCACTGTAGTACAAGGAGAAA
TGAGGGTCCCTGAAGAAGCTCTTAAGCATGAGAAGTTTACCATTCAGCTTCAGTTGTCCCAAAAATCTTCAGAATCAGAATTATCCAAAT
CTGCAAGTGCCAAAAGCATAGATTCAAAGGTAGCAGACGCTGCTACTGAAGTGCAGCACAAAACTACTGAAGCACTGAAATCCGAGGAAA
AAGCCATGGATATTTCTGCTATGCCCCGTGGTACTCCATTATATGGGCAGCCGTCATGGTGGGGGGATGATGAGGTGGATGAAAAAAGAG
CTTTCAAGACAAATGGCAAACCTGAAGAAAAAAACCATGAAGCTGGAACATCAGATATGAGGCCCCAGGATTCCTGGCGAGGTCCTCCTC
CCCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAACCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGCAGCCT
TCCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTATCCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCCCAGAG
AAGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAATTGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATCATTCT
ACAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTAGTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAACTGTGT
ATATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAAGATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTGCTTAT

>In-frame_ENST00000366543_ENST00000430571_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(amino acids)=299AA_start in transcript=323_stop in transcript=1222
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSDMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPR

--------------------------------------------------------------
>In-frame_ENST00000366543_ENST00000539513_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(transcript)=1710nt_BP=954nt
TTGGAACTGGGCAGGAGGGGATAGGGTCCGGCTCCTCGCCCTTTCCCGAGGCGCCTGCGCACTAGGCAGTCGGTCTTTGCCGTTACCGCT
ATGTGTGGGGCGTGTGTGGAATAACGTTATTGCCCAGCGGAGCTGAGGGCCCCGGAGCTCGACCGCAGCGGCAGCGACGACAACAGCGGC
GACGACGACGACGACGAGGTGGGGGGAGGACGGCGTGCGAGAGACTCACGGGACGCGACGCGCCCCGCCTCCCCCGTCCGGTCCCTCTCT
CCACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAG
GCACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAAC
ACGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGACTTTTGTGAATGATGTAAGGA
TTCCGGAACAGACTTATATCACCTTGAAACTTGAAGATAAGCTGAGATTTGGATATGATACAAATCTTTTCACTGTAGTACAAGGAGAAA
TGAGGGTCCCTGAAGAAGCTCTTAAGCATGAGAAGTTTACCATTCAGCTTCAGTTGTCCCAAAAATCTTCAGAATCAGAATTATCCAAAT
CTGCAAGTGCCAAAAGCATAGATTCAAAGGTAGCAGACGCTGCTACTGAAGTGCAGCACAAAACTACTGAAGCACTGAAATCCGAGGAAA
AAGCCATGGATATTTCTGCTATGCCCCGTGGTACTCCATTATATGGGCAGCCGTCATGGTGGGGGGATGATGAGGTGGATGAAAAAAGAG
CTTTCAAGACAAATGGCAAACCTGAAGAAAAAAACCATGAAGCTGGAACATCAGATATGAGGCCCCAGGATTCCTGGCGAGGTCCTCCTC
CCCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAACCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGCAGCCT
TCCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTATCCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCCCAGAG
AAGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAATTGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATCATTCT
ACAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTAGTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAACTGTGT
ATATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAAGATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTGCTTAT
AAAACACATTTGATGGAATAGGAGTACTGGTTTTTCATAATGGTTAAAAATGAAACCAGCTGTGGATTTCAAAACACAGTGTATTCTAGA
TCATCTAAGATCCATGCTGATTTTTATTGCACAAGAATTAGGTTTGAACTCGAGCTGGAACCTCAGCAAACTAGAGTATATATTGTTCAG
TATTTCTTTGGAAACATTTCATTAATGTACTTGTCTTACAGAAATTTCTGAACTTTAGTAAAAAAAAATAAAGTTAAACTTTTAAAACTC

>In-frame_ENST00000366543_ENST00000539513_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(amino acids)=299AA_start in transcript=323_stop in transcript=1222
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSDMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPR

--------------------------------------------------------------
>In-frame_ENST00000366544_ENST00000377191_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(transcript)=1710nt_BP=954nt
TTGGAACTGGGCAGGAGGGGATAGGGTCCGGCTCCTCGCCCTTTCCCGAGGCGCCTGCGCACTAGGCAGTCGGTCTTTGCCGTTACCGCT
ATGTGTGGGGCGTGTGTGGAATAACGTTATTGCCCAGCGGAGCTGAGGGCCCCGGAGCTCGACCGCAGCGGCAGCGACGACAACAGCGGC
GACGACGACGACGACGAGGTGGGGGGAGGACGGCGTGCGAGAGACTCACGGGACGCGACGCGCCCCGCCTCCCCCGTCCGGTCCCTCTCT
CCACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAG
GCACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAAC
ACGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGACTTTTGTGAATGATGTAAGGA
TTCCGGAACAGACTTATATCACCTTGAAACTTGAAGATAAGCTGAGATTTGGATATGATACAAATCTTTTCACTGTAGTACAAGGAGAAA
TGAGGGTCCCTGAAGAAGCTCTTAAGCATGAGAAGTTTACCATTCAGCTTCAGTTGTCCCAAAAATCTTCAGAATCAGAATTATCCAAAT
CTGCAAGTGCCAAAAGCATAGATTCAAAGGTAGCAGACGCTGCTACTGAAGTGCAGCACAAAACTACTGAAGCACTGAAATCCGAGGAAA
AAGCCATGGATATTTCTGCTATGCCCCGTGGTACTCCATTATATGGGCAGCCGTCATGGTGGGGGGATGATGAGGTGGATGAAAAAAGAG
CTTTCAAGACAAATGGCAAACCTGAAGAAAAAAACCATGAAGCTGGAACATCAGATATGAGGCCCCAGGATTCCTGGCGAGGTCCTCCTC
CCCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAACCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGCAGCCT
TCCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTATCCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCCCAGAG
AAGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAATTGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATCATTCT
ACAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTAGTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAACTGTGT
ATATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAAGATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTGCTTAT
AAAACACATTTGATGGAATAGGAGTACTGGTTTTTCATAATGGTTAAAAATGAAACCAGCTGTGGATTTCAAAACACAGTGTATTCTAGA
TCATCTAAGATCCATGCTGATTTTTATTGCACAAGAATTAGGTTTGAACTCGAGCTGGAACCTCAGCAAACTAGAGTATATATTGTTCAG
TATTTCTTTGGAAACATTTCATTAATGTACTTGTCTTACAGAAATTTCTGAACTTTAGTAAAAAAAAATAAAGTTAAACTTTTAAAACTC

>In-frame_ENST00000366544_ENST00000377191_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(amino acids)=299AA_start in transcript=323_stop in transcript=1222
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSDMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPR

--------------------------------------------------------------
>In-frame_ENST00000366544_ENST00000430571_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(transcript)=1510nt_BP=954nt
TTGGAACTGGGCAGGAGGGGATAGGGTCCGGCTCCTCGCCCTTTCCCGAGGCGCCTGCGCACTAGGCAGTCGGTCTTTGCCGTTACCGCT
ATGTGTGGGGCGTGTGTGGAATAACGTTATTGCCCAGCGGAGCTGAGGGCCCCGGAGCTCGACCGCAGCGGCAGCGACGACAACAGCGGC
GACGACGACGACGACGAGGTGGGGGGAGGACGGCGTGCGAGAGACTCACGGGACGCGACGCGCCCCGCCTCCCCCGTCCGGTCCCTCTCT
CCACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAG
GCACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAAC
ACGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGACTTTTGTGAATGATGTAAGGA
TTCCGGAACAGACTTATATCACCTTGAAACTTGAAGATAAGCTGAGATTTGGATATGATACAAATCTTTTCACTGTAGTACAAGGAGAAA
TGAGGGTCCCTGAAGAAGCTCTTAAGCATGAGAAGTTTACCATTCAGCTTCAGTTGTCCCAAAAATCTTCAGAATCAGAATTATCCAAAT
CTGCAAGTGCCAAAAGCATAGATTCAAAGGTAGCAGACGCTGCTACTGAAGTGCAGCACAAAACTACTGAAGCACTGAAATCCGAGGAAA
AAGCCATGGATATTTCTGCTATGCCCCGTGGTACTCCATTATATGGGCAGCCGTCATGGTGGGGGGATGATGAGGTGGATGAAAAAAGAG
CTTTCAAGACAAATGGCAAACCTGAAGAAAAAAACCATGAAGCTGGAACATCAGATATGAGGCCCCAGGATTCCTGGCGAGGTCCTCCTC
CCCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAACCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGCAGCCT
TCCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTATCCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCCCAGAG
AAGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAATTGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATCATTCT
ACAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTAGTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAACTGTGT
ATATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAAGATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTGCTTAT

>In-frame_ENST00000366544_ENST00000430571_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(amino acids)=299AA_start in transcript=323_stop in transcript=1222
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSDMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPR

--------------------------------------------------------------
>In-frame_ENST00000366544_ENST00000539513_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(transcript)=1710nt_BP=954nt
TTGGAACTGGGCAGGAGGGGATAGGGTCCGGCTCCTCGCCCTTTCCCGAGGCGCCTGCGCACTAGGCAGTCGGTCTTTGCCGTTACCGCT
ATGTGTGGGGCGTGTGTGGAATAACGTTATTGCCCAGCGGAGCTGAGGGCCCCGGAGCTCGACCGCAGCGGCAGCGACGACAACAGCGGC
GACGACGACGACGACGAGGTGGGGGGAGGACGGCGTGCGAGAGACTCACGGGACGCGACGCGCCCCGCCTCCCCCGTCCGGTCCCTCTCT
CCACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAG
GCACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAAC
ACGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGACTTTTGTGAATGATGTAAGGA
TTCCGGAACAGACTTATATCACCTTGAAACTTGAAGATAAGCTGAGATTTGGATATGATACAAATCTTTTCACTGTAGTACAAGGAGAAA
TGAGGGTCCCTGAAGAAGCTCTTAAGCATGAGAAGTTTACCATTCAGCTTCAGTTGTCCCAAAAATCTTCAGAATCAGAATTATCCAAAT
CTGCAAGTGCCAAAAGCATAGATTCAAAGGTAGCAGACGCTGCTACTGAAGTGCAGCACAAAACTACTGAAGCACTGAAATCCGAGGAAA
AAGCCATGGATATTTCTGCTATGCCCCGTGGTACTCCATTATATGGGCAGCCGTCATGGTGGGGGGATGATGAGGTGGATGAAAAAAGAG
CTTTCAAGACAAATGGCAAACCTGAAGAAAAAAACCATGAAGCTGGAACATCAGATATGAGGCCCCAGGATTCCTGGCGAGGTCCTCCTC
CCCTTTTCCAGCAGCAAAGGTTTGACAGAGGCGTTGGGGCTGAACCTCTGCTCCCATGGAACCGGATGCTGCAAACCCAGAATGCAGCCT
TCCAGCCAAACCAGTACCAGATGCTAGCTGGGCCTGGTGGGTATCCACCCAGACGAGATGATCGTGGAGGGAGACAGGGATATCCCAGAG
AAGGAAGGAAATACCCTTTGCCACCACCCTCAGGAAGATACAATTGGAATTAAGCTTTTGTAAAGCTTTCCCAAATCCTTTCATCATTCT
ACAGTTTTATGCTATTTGTGGAAAGATTTCTTTCTCAAGTAGTAGTTTTTAATAAAACTACAGTACTTTGTGTATTTCTTTTAACTGTGT
ATATTTCTACTGATCTGATCTCACTGTTTATGTTGCTTTCCAAAGATGTATGTTGCATAATACAGTGGATCTGAATTTATTATTGCTTAT
AAAACACATTTGATGGAATAGGAGTACTGGTTTTTCATAATGGTTAAAAATGAAACCAGCTGTGGATTTCAAAACACAGTGTATTCTAGA
TCATCTAAGATCCATGCTGATTTTTATTGCACAAGAATTAGGTTTGAACTCGAGCTGGAACCTCAGCAAACTAGAGTATATATTGTTCAG
TATTTCTTTGGAAACATTTCATTAATGTACTTGTCTTACAGAAATTTCTGAACTTTAGTAAAAAAAAATAAAGTTAAACTTTTAAAACTC

>In-frame_ENST00000366544_ENST00000539513_TCGA-BR-6852-11A_CEP170_chr1_243362361_-_XRN2_chr20_21362631_length(amino acids)=299AA_start in transcript=323_stop in transcript=1222
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSDMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CEP170-XRN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCEP170chr1:243362361chr20:21362631ENST00000366542-7201015_1460210.333333333333341585.0CCDC61
HgeneCEP170chr1:243362361chr20:21362631ENST00000366543-7191015_1460210.333333333333341461.0CCDC61
HgeneCEP170chr1:243362361chr20:21362631ENST00000366544-7191015_1460210.333333333333341487.0CCDC61


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CEP170-XRN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CEP170-XRN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource