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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CEP85L-ROS1 (FusionGDB2 ID:15953)

Fusion Gene Summary for CEP85L-ROS1

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP85L-ROS1
Fusion gene ID: 15953
HgeneTgene
Gene symbol

CEP85L

ROS1

Gene ID

387119

6098

Gene namecentrosomal protein 85 likeROS proto-oncogene 1, receptor tyrosine kinase
SynonymsC6orf204|NY-BR-15|bA57K17.2MCF3|ROS|c-ros-1
Cytomap

6q22.31

6q22.1

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 85 kDa-likecentrosomal protein 85kDa-likeserologically defined breast cancer antigen NY-BR-15proto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1
Modification date2020031320200314
UniProtAcc

Q5SZL2

P08922

Ensembl transtripts involved in fusion geneENST00000368491, ENST00000368488, 
ENST00000360290, ENST00000392500, 
ENST00000419517, ENST00000472713, 
ENST00000368508, ENST00000368507, 
Fusion gene scores* DoF score10 X 10 X 6=60018 X 20 X 5=1800
# samples 1120
** MAII scorelog2(11/600*10)=-2.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1800*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP85L [Title/Abstract] AND ROS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCEP85L(118802942)-ROS1(117641193), # samples:2
Anticipated loss of major functional domain due to fusion event.CEP85L-ROS1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
CEP85L-ROS1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CEP85L-ROS1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneROS1

GO:0001558

regulation of cell growth

16885344

TgeneROS1

GO:0006468

protein phosphorylation

16885344

TgeneROS1

GO:0032006

regulation of TOR signaling

16885344


check buttonFusion gene breakpoints across CEP85L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ROS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-5418-01ACEP85Lchr6

118802942

-ROS1chr6

117641193

-
ChimerDB4GBMTCGA-06-5418-01ACEP85Lchr6

118802942

-ROS1chr6

117641193

-


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Fusion Gene ORF analysis for CEP85L-ROS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000368491ENST00000368508CEP85Lchr6

118802942

-ROS1chr6

117641193

-
In-frameENST00000368491ENST00000368507CEP85Lchr6

118802942

-ROS1chr6

117641193

-
Frame-shiftENST00000368488ENST00000368508CEP85Lchr6

118802942

-ROS1chr6

117641193

-
Frame-shiftENST00000368488ENST00000368507CEP85Lchr6

118802942

-ROS1chr6

117641193

-
intron-3CDSENST00000360290ENST00000368508CEP85Lchr6

118802942

-ROS1chr6

117641193

-
intron-3CDSENST00000360290ENST00000368507CEP85Lchr6

118802942

-ROS1chr6

117641193

-
intron-3CDSENST00000392500ENST00000368508CEP85Lchr6

118802942

-ROS1chr6

117641193

-
intron-3CDSENST00000392500ENST00000368507CEP85Lchr6

118802942

-ROS1chr6

117641193

-
intron-3CDSENST00000419517ENST00000368508CEP85Lchr6

118802942

-ROS1chr6

117641193

-
intron-3CDSENST00000419517ENST00000368507CEP85Lchr6

118802942

-ROS1chr6

117641193

-
intron-3CDSENST00000472713ENST00000368508CEP85Lchr6

118802942

-ROS1chr6

117641193

-
intron-3CDSENST00000472713ENST00000368507CEP85Lchr6

118802942

-ROS1chr6

117641193

-
intron-intronENST00000360290ENST00000368507CEP85Lchr6

118791807

-ROS1chr6

118791807

-
intron-intronENST00000360290ENST00000368507CEP85Lchr6

118805021

-ROS1chr6

118805021

-
intron-intronENST00000360290ENST00000368508CEP85Lchr6

118791807

-ROS1chr6

118791807

-
intron-intronENST00000360290ENST00000368508CEP85Lchr6

118805021

-ROS1chr6

118805021

-
intron-intronENST00000368488ENST00000368507CEP85Lchr6

118791807

-ROS1chr6

118791807

-
intron-intronENST00000368488ENST00000368507CEP85Lchr6

118805021

-ROS1chr6

118805021

-
intron-intronENST00000368488ENST00000368508CEP85Lchr6

118791807

-ROS1chr6

118791807

-
intron-intronENST00000368488ENST00000368508CEP85Lchr6

118805021

-ROS1chr6

118805021

-
intron-intronENST00000368491ENST00000368507CEP85Lchr6

118791807

-ROS1chr6

118791807

-
intron-intronENST00000368491ENST00000368507CEP85Lchr6

118805021

-ROS1chr6

118805021

-
intron-intronENST00000368491ENST00000368508CEP85Lchr6

118791807

-ROS1chr6

118791807

-
intron-intronENST00000368491ENST00000368508CEP85Lchr6

118805021

-ROS1chr6

118805021

-
intron-intronENST00000392500ENST00000368507CEP85Lchr6

118791807

-ROS1chr6

118791807

-
intron-intronENST00000392500ENST00000368507CEP85Lchr6

118805021

-ROS1chr6

118805021

-
intron-intronENST00000392500ENST00000368508CEP85Lchr6

118791807

-ROS1chr6

118791807

-
intron-intronENST00000392500ENST00000368508CEP85Lchr6

118805021

-ROS1chr6

118805021

-
intron-intronENST00000419517ENST00000368507CEP85Lchr6

118791807

-ROS1chr6

118791807

-
intron-intronENST00000419517ENST00000368507CEP85Lchr6

118805021

-ROS1chr6

118805021

-
intron-intronENST00000419517ENST00000368508CEP85Lchr6

118791807

-ROS1chr6

118791807

-
intron-intronENST00000419517ENST00000368508CEP85Lchr6

118805021

-ROS1chr6

118805021

-
intron-intronENST00000472713ENST00000368507CEP85Lchr6

118791807

-ROS1chr6

118791807

-
intron-intronENST00000472713ENST00000368507CEP85Lchr6

118805021

-ROS1chr6

118805021

-
intron-intronENST00000472713ENST00000368508CEP85Lchr6

118791807

-ROS1chr6

118791807

-
intron-intronENST00000472713ENST00000368508CEP85Lchr6

118805021

-ROS1chr6

118805021

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368491CEP85Lchr6118802942-ENST00000368508ROS1chr6117641193-3826236751136331040
ENST00000368491CEP85Lchr6118802942-ENST00000368507ROS1chr6117641193-3826236751136331040

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368491ENST00000368508CEP85Lchr6118802942-ROS1chr6117641193-0.0014159560.99858403
ENST00000368491ENST00000368507CEP85Lchr6118802942-ROS1chr6117641193-0.0014159560.99858403

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Fusion Genomic Features for CEP85L-ROS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CEP85L-ROS1


check button Go to

FGviewer for the breakpoints of chr6:118802942-chr6:117641193

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP85L

Q5SZL2

ROS1

P08922

FUNCTION: Plays an essential role in neuronal cell migration. {ECO:0000269|PubMed:32097630}.FUNCTION: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269|PubMed:11094073, ECO:0000269|PubMed:16885344}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneROS1chr6:118802942chr6:117641193ENST0000036850834431945_22221925.66666666666672348.0DomainProtein kinase
TgeneROS1chr6:118802942chr6:117641193ENST0000036850834431951_19591925.66666666666672348.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP85Lchr6:118802942chr6:117641193ENST00000360290-16439_6820395.0Coiled coilOntology_term=ECO:0000255
HgeneCEP85Lchr6:118802942chr6:117641193ENST00000368488-914439_682584.6666666666666809.0Coiled coilOntology_term=ECO:0000255
HgeneCEP85Lchr6:118802942chr6:117641193ENST00000368491-813439_682581.6666666666666806.0Coiled coilOntology_term=ECO:0000255
HgeneCEP85Lchr6:118802942chr6:117641193ENST00000392500-18439_6820500.0Coiled coilOntology_term=ECO:0000255
HgeneCEP85Lchr6:118802942chr6:117641193ENST00000419517-16439_6820497.0Coiled coilOntology_term=ECO:0000255
TgeneROS1chr6:118802942chr6:117641193ENST000003685083443101_1961925.66666666666672348.0DomainFibronectin type-III 1
TgeneROS1chr6:118802942chr6:117641193ENST0000036850834431043_11501925.66666666666672348.0DomainFibronectin type-III 5
TgeneROS1chr6:118802942chr6:117641193ENST0000036850834431450_15561925.66666666666672348.0DomainFibronectin type-III 6
TgeneROS1chr6:118802942chr6:117641193ENST0000036850834431557_16561925.66666666666672348.0DomainFibronectin type-III 7
TgeneROS1chr6:118802942chr6:117641193ENST0000036850834431658_17511925.66666666666672348.0DomainFibronectin type-III 8
TgeneROS1chr6:118802942chr6:117641193ENST0000036850834431752_18541925.66666666666672348.0DomainFibronectin type-III 9
TgeneROS1chr6:118802942chr6:117641193ENST000003685083443197_2851925.66666666666672348.0DomainFibronectin type-III 2
TgeneROS1chr6:118802942chr6:117641193ENST000003685083443557_6711925.66666666666672348.0DomainFibronectin type-III 3
TgeneROS1chr6:118802942chr6:117641193ENST000003685083443947_10421925.66666666666672348.0DomainFibronectin type-III 4
TgeneROS1chr6:118802942chr6:117641193ENST0000036850834431883_23471925.66666666666672348.0Topological domainCytoplasmic
TgeneROS1chr6:118802942chr6:117641193ENST00000368508344328_18591925.66666666666672348.0Topological domainExtracellular
TgeneROS1chr6:118802942chr6:117641193ENST0000036850834431860_18821925.66666666666672348.0TransmembraneHelical


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Fusion Gene Sequence for CEP85L-ROS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000368491_ENST00000368508_TCGA-06-5418-01A_CEP85L_chr6_118802942_-_ROS1_chr6_117641193_length(transcript)=3826nt_BP=2367nt
GGGAGGGCGTGAGGGATTACCCAAGGGAGGGGCGAGTATCGCAAAATAGGCCAAGTCGCTGCCCTCTACTCAACTCGCAGGGCGGGAGGA
TGGAGACAGAGGGATGCGGCGGGAGGGCGGGACAGCCCAGTCGCCGCCAAGGAGGCGAAGCGGGGTCGGGGTAGCTCACCCGCCCCCCGC
AGTCCCCGCCCCCCGCAGTCCCCGCCCCGCGCGGCGCCGCGCACGCCTGAAGTCATTGCCCGAGGCCCCGCCCCCTCGCGGCCCCAGCCC
CGGCTCTGGCTCTGCCGGCGGAGGGGGCGGAGAGAACCCGCAGCTGCAACTTCGCCTGGAGCCTTTGAGCCTGGGCTCAGCCGGGGATCT
AGCAGCCGTCACCGCCGAGTCGCCGCTTCCCCGGCGCGGGCCTCAGCCCAGCCGGCTTGGCCATGGCAGGCGCCGGCAGTGCGGCGAATC
TGGCCCCTGCGCTCCCCGCCCGTAGCTGAGCAGCCGTTAACCAGCCATCCCGCCTTTCCTCCTGCCCGTGTCGCCGAGGCCCACGCTCCG
CGCAAGTTTCCGCCGCCGAAGAAGCAGGAGGACGGACGTGAGGAGTCGGGCGTCCCTGGCCCACCCGGCCCTCTCGCCCGCGATGTGGGG
GCGCTTCCTGGCTCCGGAGGCCAGCGGCCGGGATAGCCCCGGCGGAGCCCGCAGCTTCCCTGCCGGCCCAGATTATTCATCAGCATGGCT
ACCTGCTAATGAATCATTGTGGCAGGCCACAACTGTTCCATCTAACCATCGAAATAACCATATCAGGAGACACAGTATAGCTTCTGACAG
TGGAGACACTGGCATTGGAACTTCCTGTTCTGATAGCGTGGAAGATCATTCAACTTCAAGTGGCACATTATCTTTTAAGCCTAGTCAATC
ATTGATTACTCTTCCTACTGCCCATGTGATGCCGTCTAATTCCAGCGCTTCAATTTCCAAACTTAGGGAATCATTGACACCAGATGGCTC
AAAATGGAGTACAAGCCTCATGCAAACATTGGGAAACCACAGTAGGGGGGAGCAGGACTCTTCCCTAGACATGAAGGACTTCCGGCCACT
TCGGAAATGGTCATCTTTATCCAAACTCACTGCCCCGGATAACTGTGGCCAGGGTGGCACTGTATGCAGAGAAGAGTCAAGGAATGGTTT
GGAGAAGATAGGGAAGGCTAAGGCTTTAACATCACAACTGAGGACAATTGGGCCTAGCTGTTTACATGATAGTATGGAGATGCTTAGGTT
AGAGGACAAGGAAATAAATAAAAAACGGTCATCAACTCTGGACTGCAAGTATAAATTTGAGAGCTGTAGCAAGGAGGACTTTAGAGCCTC
TTCCTCTACTCTTAGGAGACAGCCTGTAGACATGACATATAGTGCCTTACCTGAAAGCAAGCCCATTATGACAAGCTCAGAGGCTTTTGA
ACCTCCAAAATATTTAATGCTTGGTCAACAGGCAGTAGGTGGAGTTCCCATTCAGCCTTCCGTAAGGACTCAGATGTGGCTTACAGAGCA
GCTGCGGACAAATCCTTTGGAAGGTAGAAATACAGAGGATTCTTACAGTTTAGCTCCTTGGCAACAGCAGCAAATTGAAGACTTTCGACA
AGGAAGTGAAACACCAATGCAGGTTTTGACTGGATCATCTCGTCAAAGTTATTCACCTGGCTATCAGGATTTCAGTAAGTGGGAATCAAT
GTTGAAAATAAAAGAAGGACTTCTAAGGCAGAAAGAAATTGTAATCGATCGGCAGAAGCAACAAATTACCCACCTGCATGAGAGGATAAG
GGATAATGAATTACGGGCTCAACATGCCATGTTAGGACATTATGTAAATTGTGAGGATTCTTATGTGGCTAGTTTGCAGCCACAATATGA
GAACACTTCACTCCAGACACCATTTTCAGAGGAATCAGTTTCCCATTCCCAACAAGGGGAATTTGAGCAAAAGCTTGCATCTACTGAGAA
AGAAGTTTTACAGCTTAATGAGTTTCTCAAACAAAGACTAAGCCTATTTAGTGAAGAGAAGAAGAAACTAGAGGAAAAACTTAAAACTAG
AGATCGATACATCAGTAGTCTGAAAAAGAAATGCCAGAAGGAATCTGAACAAAACAAAGAAAAGCAGAGAAGAATTGAGACCTTGGAAAA
GTATCTGGCTGATCTTCCAACTCTAGATGATGTACAGAGTCAGAGTCTACAGCTGCAGATTCTGGAAGAAAAAAATAAGAATTTACAAGA
GGCTTTGATAGATACAGAAAAAAAACTTGAAGAGATCAAAAAGCAGTGTCAAGATAAAGAGACACAGTTAATATGCCAGAAAAAGAAAGA
AAAGGAGTTAGTAACTACCGTTCAGAGTACTCTTCCAACCCAAGAGGAGATTGAAAATCTTCCTGCCTTCCCTCGGGAAAAACTGACTCT
GCGTCTCTTGCTGGGAAGTGGAGCCTTTGGAGAAGTGTATGAAGGAACAGCAGTGGACATCTTAGGAGTTGGAAGTGGAGAAATCAAAGT
AGCAGTGAAGACTTTGAAGAAGGGTTCCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTGATGAGCAAATTTAATCATCC
CAACATTCTGAAGCAGCTTGGAGTTTGTCTGCTGAATGAACCCCAATACATTATCCTGGAACTGATGGAGGGAGGAGACCTTCTTACTTA
TTTGCGTAAAGCCCGGATGGCAACGTTTTATGGTCCTTTACTCACCTTGGTTGACCTTGTAGACCTGTGTGTAGATATTTCAAAAGGCTG
TGTCTACTTGGAACGGATGCATTTCATTCACAGGGATCTGGCAGCTAGAAATTGCCTTGTTTCCGTGAAAGACTATACCAGTCCACGGAT
AGTGAAGATTGGAGACTTTGGACTCGCCAGAGACATCTATAAAAATGATTACTATAGAAAGAGAGGGGAAGGCCTGCTCCCAGTTCGGTG
GATGGCTCCAGAAAGTTTGATGGATGGAATCTTCACTACTCAATCTGATGTATGGTCTTTTGGAATTCTGATTTGGGAGATTTTAACTCT
TGGTCATCAGCCTTATCCAGCTCATTCCAACCTTGATGTGTTAAACTATGTGCAAACAGGAGGGAGACTGGAGCCACCAAGAAATTGTCC
TGATGATCTGTGGAATTTAATGACCCAGTGCTGGGCTCAAGAACCCGACCAAAGACCTACTTTTCATAGAATTCAGGACCAACTTCAGTT
ATTCAGAAATTTTTTCTTAAATAGCATTTATAAGTCCAGAGATGAAGCAAACAACAGTGGAGTCATAAATGAAAGCTTTGAAGGTGAAGA
TGGCGATGTGATTTGTTTGAATTCAGATGACATTATGCCAGTTGCTTTAATGGAAACGAAGAACCGAGAAGGGTTAAACTATATGGTACT
TGCTACAGAATGTGGCCAAGGTGAAGAAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCTGAATCTTGTGGTCTGAGGAAAGAAGAGAA
GGAACCACATGCAGACAAAGATTTCTGCCAAGAAAAACAAGTGGCTTACTGCCCTTCTGGCAAGCCTGAAGGCCTGAACTATGCCTGTCT
CACTCACAGTGGATATGGAGATGGGTCTGATTAATAGCGTTGTTTGGGAAATAGAGAGTTGAGATAAACACTCTCATTCAGTAGTTACTG
AAAGAAAACTCTGCTAGAATGATAAATGTCATGGTGGTCTATAACTCCAAATAAACAATGCAACGTTCCTGATTTCTAATCTTGGTTCTG

>In-frame_ENST00000368491_ENST00000368508_TCGA-06-5418-01A_CEP85L_chr6_118802942_-_ROS1_chr6_117641193_length(amino acids)=1040AA_start in transcript=511_stop in transcript=3633
MPVSPRPTLRASFRRRRSRRTDVRSRASLAHPALSPAMWGRFLAPEASGRDSPGGARSFPAGPDYSSAWLPANESLWQATTVPSNHRNNH
IRRHSIASDSGDTGIGTSCSDSVEDHSTSSGTLSFKPSQSLITLPTAHVMPSNSSASISKLRESLTPDGSKWSTSLMQTLGNHSRGEQDS
SLDMKDFRPLRKWSSLSKLTAPDNCGQGGTVCREESRNGLEKIGKAKALTSQLRTIGPSCLHDSMEMLRLEDKEINKKRSSTLDCKYKFE
SCSKEDFRASSSTLRRQPVDMTYSALPESKPIMTSSEAFEPPKYLMLGQQAVGGVPIQPSVRTQMWLTEQLRTNPLEGRNTEDSYSLAPW
QQQQIEDFRQGSETPMQVLTGSSRQSYSPGYQDFSKWESMLKIKEGLLRQKEIVIDRQKQQITHLHERIRDNELRAQHAMLGHYVNCEDS
YVASLQPQYENTSLQTPFSEESVSHSQQGEFEQKLASTEKEVLQLNEFLKQRLSLFSEEKKKLEEKLKTRDRYISSLKKKCQKESEQNKE
KQRRIETLEKYLADLPTLDDVQSQSLQLQILEEKNKNLQEALIDTEKKLEEIKKQCQDKETQLICQKKKEKELVTTVQSTLPTQEEIENL
PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILE
LMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK
RGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPT
FHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQES

--------------------------------------------------------------
>In-frame_ENST00000368491_ENST00000368507_TCGA-06-5418-01A_CEP85L_chr6_118802942_-_ROS1_chr6_117641193_length(transcript)=3826nt_BP=2367nt
GGGAGGGCGTGAGGGATTACCCAAGGGAGGGGCGAGTATCGCAAAATAGGCCAAGTCGCTGCCCTCTACTCAACTCGCAGGGCGGGAGGA
TGGAGACAGAGGGATGCGGCGGGAGGGCGGGACAGCCCAGTCGCCGCCAAGGAGGCGAAGCGGGGTCGGGGTAGCTCACCCGCCCCCCGC
AGTCCCCGCCCCCCGCAGTCCCCGCCCCGCGCGGCGCCGCGCACGCCTGAAGTCATTGCCCGAGGCCCCGCCCCCTCGCGGCCCCAGCCC
CGGCTCTGGCTCTGCCGGCGGAGGGGGCGGAGAGAACCCGCAGCTGCAACTTCGCCTGGAGCCTTTGAGCCTGGGCTCAGCCGGGGATCT
AGCAGCCGTCACCGCCGAGTCGCCGCTTCCCCGGCGCGGGCCTCAGCCCAGCCGGCTTGGCCATGGCAGGCGCCGGCAGTGCGGCGAATC
TGGCCCCTGCGCTCCCCGCCCGTAGCTGAGCAGCCGTTAACCAGCCATCCCGCCTTTCCTCCTGCCCGTGTCGCCGAGGCCCACGCTCCG
CGCAAGTTTCCGCCGCCGAAGAAGCAGGAGGACGGACGTGAGGAGTCGGGCGTCCCTGGCCCACCCGGCCCTCTCGCCCGCGATGTGGGG
GCGCTTCCTGGCTCCGGAGGCCAGCGGCCGGGATAGCCCCGGCGGAGCCCGCAGCTTCCCTGCCGGCCCAGATTATTCATCAGCATGGCT
ACCTGCTAATGAATCATTGTGGCAGGCCACAACTGTTCCATCTAACCATCGAAATAACCATATCAGGAGACACAGTATAGCTTCTGACAG
TGGAGACACTGGCATTGGAACTTCCTGTTCTGATAGCGTGGAAGATCATTCAACTTCAAGTGGCACATTATCTTTTAAGCCTAGTCAATC
ATTGATTACTCTTCCTACTGCCCATGTGATGCCGTCTAATTCCAGCGCTTCAATTTCCAAACTTAGGGAATCATTGACACCAGATGGCTC
AAAATGGAGTACAAGCCTCATGCAAACATTGGGAAACCACAGTAGGGGGGAGCAGGACTCTTCCCTAGACATGAAGGACTTCCGGCCACT
TCGGAAATGGTCATCTTTATCCAAACTCACTGCCCCGGATAACTGTGGCCAGGGTGGCACTGTATGCAGAGAAGAGTCAAGGAATGGTTT
GGAGAAGATAGGGAAGGCTAAGGCTTTAACATCACAACTGAGGACAATTGGGCCTAGCTGTTTACATGATAGTATGGAGATGCTTAGGTT
AGAGGACAAGGAAATAAATAAAAAACGGTCATCAACTCTGGACTGCAAGTATAAATTTGAGAGCTGTAGCAAGGAGGACTTTAGAGCCTC
TTCCTCTACTCTTAGGAGACAGCCTGTAGACATGACATATAGTGCCTTACCTGAAAGCAAGCCCATTATGACAAGCTCAGAGGCTTTTGA
ACCTCCAAAATATTTAATGCTTGGTCAACAGGCAGTAGGTGGAGTTCCCATTCAGCCTTCCGTAAGGACTCAGATGTGGCTTACAGAGCA
GCTGCGGACAAATCCTTTGGAAGGTAGAAATACAGAGGATTCTTACAGTTTAGCTCCTTGGCAACAGCAGCAAATTGAAGACTTTCGACA
AGGAAGTGAAACACCAATGCAGGTTTTGACTGGATCATCTCGTCAAAGTTATTCACCTGGCTATCAGGATTTCAGTAAGTGGGAATCAAT
GTTGAAAATAAAAGAAGGACTTCTAAGGCAGAAAGAAATTGTAATCGATCGGCAGAAGCAACAAATTACCCACCTGCATGAGAGGATAAG
GGATAATGAATTACGGGCTCAACATGCCATGTTAGGACATTATGTAAATTGTGAGGATTCTTATGTGGCTAGTTTGCAGCCACAATATGA
GAACACTTCACTCCAGACACCATTTTCAGAGGAATCAGTTTCCCATTCCCAACAAGGGGAATTTGAGCAAAAGCTTGCATCTACTGAGAA
AGAAGTTTTACAGCTTAATGAGTTTCTCAAACAAAGACTAAGCCTATTTAGTGAAGAGAAGAAGAAACTAGAGGAAAAACTTAAAACTAG
AGATCGATACATCAGTAGTCTGAAAAAGAAATGCCAGAAGGAATCTGAACAAAACAAAGAAAAGCAGAGAAGAATTGAGACCTTGGAAAA
GTATCTGGCTGATCTTCCAACTCTAGATGATGTACAGAGTCAGAGTCTACAGCTGCAGATTCTGGAAGAAAAAAATAAGAATTTACAAGA
GGCTTTGATAGATACAGAAAAAAAACTTGAAGAGATCAAAAAGCAGTGTCAAGATAAAGAGACACAGTTAATATGCCAGAAAAAGAAAGA
AAAGGAGTTAGTAACTACCGTTCAGAGTACTCTTCCAACCCAAGAGGAGATTGAAAATCTTCCTGCCTTCCCTCGGGAAAAACTGACTCT
GCGTCTCTTGCTGGGAAGTGGAGCCTTTGGAGAAGTGTATGAAGGAACAGCAGTGGACATCTTAGGAGTTGGAAGTGGAGAAATCAAAGT
AGCAGTGAAGACTTTGAAGAAGGGTTCCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTGATGAGCAAATTTAATCATCC
CAACATTCTGAAGCAGCTTGGAGTTTGTCTGCTGAATGAACCCCAATACATTATCCTGGAACTGATGGAGGGAGGAGACCTTCTTACTTA
TTTGCGTAAAGCCCGGATGGCAACGTTTTATGGTCCTTTACTCACCTTGGTTGACCTTGTAGACCTGTGTGTAGATATTTCAAAAGGCTG
TGTCTACTTGGAACGGATGCATTTCATTCACAGGGATCTGGCAGCTAGAAATTGCCTTGTTTCCGTGAAAGACTATACCAGTCCACGGAT
AGTGAAGATTGGAGACTTTGGACTCGCCAGAGACATCTATAAAAATGATTACTATAGAAAGAGAGGGGAAGGCCTGCTCCCAGTTCGGTG
GATGGCTCCAGAAAGTTTGATGGATGGAATCTTCACTACTCAATCTGATGTATGGTCTTTTGGAATTCTGATTTGGGAGATTTTAACTCT
TGGTCATCAGCCTTATCCAGCTCATTCCAACCTTGATGTGTTAAACTATGTGCAAACAGGAGGGAGACTGGAGCCACCAAGAAATTGTCC
TGATGATCTGTGGAATTTAATGACCCAGTGCTGGGCTCAAGAACCCGACCAAAGACCTACTTTTCATAGAATTCAGGACCAACTTCAGTT
ATTCAGAAATTTTTTCTTAAATAGCATTTATAAGTCCAGAGATGAAGCAAACAACAGTGGAGTCATAAATGAAAGCTTTGAAGGTGAAGA
TGGCGATGTGATTTGTTTGAATTCAGATGACATTATGCCAGTTGCTTTAATGGAAACGAAGAACCGAGAAGGGTTAAACTATATGGTACT
TGCTACAGAATGTGGCCAAGGTGAAGAAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCTGAATCTTGTGGTCTGAGGAAAGAAGAGAA
GGAACCACATGCAGACAAAGATTTCTGCCAAGAAAAACAAGTGGCTTACTGCCCTTCTGGCAAGCCTGAAGGCCTGAACTATGCCTGTCT
CACTCACAGTGGATATGGAGATGGGTCTGATTAATAGCGTTGTTTGGGAAATAGAGAGTTGAGATAAACACTCTCATTCAGTAGTTACTG
AAAGAAAACTCTGCTAGAATGATAAATGTCATGGTGGTCTATAACTCCAAATAAACAATGCAACGTTCCTGATTTCTAATCTTGGTTCTG

>In-frame_ENST00000368491_ENST00000368507_TCGA-06-5418-01A_CEP85L_chr6_118802942_-_ROS1_chr6_117641193_length(amino acids)=1040AA_start in transcript=511_stop in transcript=3633
MPVSPRPTLRASFRRRRSRRTDVRSRASLAHPALSPAMWGRFLAPEASGRDSPGGARSFPAGPDYSSAWLPANESLWQATTVPSNHRNNH
IRRHSIASDSGDTGIGTSCSDSVEDHSTSSGTLSFKPSQSLITLPTAHVMPSNSSASISKLRESLTPDGSKWSTSLMQTLGNHSRGEQDS
SLDMKDFRPLRKWSSLSKLTAPDNCGQGGTVCREESRNGLEKIGKAKALTSQLRTIGPSCLHDSMEMLRLEDKEINKKRSSTLDCKYKFE
SCSKEDFRASSSTLRRQPVDMTYSALPESKPIMTSSEAFEPPKYLMLGQQAVGGVPIQPSVRTQMWLTEQLRTNPLEGRNTEDSYSLAPW
QQQQIEDFRQGSETPMQVLTGSSRQSYSPGYQDFSKWESMLKIKEGLLRQKEIVIDRQKQQITHLHERIRDNELRAQHAMLGHYVNCEDS
YVASLQPQYENTSLQTPFSEESVSHSQQGEFEQKLASTEKEVLQLNEFLKQRLSLFSEEKKKLEEKLKTRDRYISSLKKKCQKESEQNKE
KQRRIETLEKYLADLPTLDDVQSQSLQLQILEEKNKNLQEALIDTEKKLEEIKKQCQDKETQLICQKKKEKELVTTVQSTLPTQEEIENL
PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILE
LMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK
RGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPT
FHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQES

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Fusion Gene PPI Analysis for CEP85L-ROS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CEP85L-ROS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneROS1P08922DB11986EntrectinibInhibitorSmall moleculeApproved|Investigational
TgeneROS1P08922DB11986EntrectinibInhibitorSmall moleculeApproved|Investigational
TgeneROS1P08922DB11986EntrectinibInhibitorSmall moleculeApproved|Investigational
TgeneROS1P08922DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneROS1P08922DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneROS1P08922DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for CEP85L-ROS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneROS1C0007131Non-Small Cell Lung Carcinoma4CTD_human
TgeneROS1C0017638Glioma1CTD_human
TgeneROS1C0025202melanoma1CTD_human
TgeneROS1C0152013Adenocarcinoma of lung (disorder)1CGI;CTD_human
TgeneROS1C0259783mixed gliomas1CTD_human
TgeneROS1C0555198Malignant Glioma1CTD_human