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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CFB-CCT5 (FusionGDB2 ID:16109)

Fusion Gene Summary for CFB-CCT5

check button Fusion gene summary
Fusion gene informationFusion gene name: CFB-CCT5
Fusion gene ID: 16109
HgeneTgene
Gene symbol

CFB

CCT5

Gene ID

629

22948

Gene namecomplement factor Bchaperonin containing TCP1 subunit 5
SynonymsAHUS4|ARMD14|BF|BFD|CFAB|CFBD|FB|FBI12|GBG|H2-Bf|PBF2CCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon
Cytomap

6p21.33

5p15.2

Type of geneprotein-codingprotein-coding
Descriptioncomplement factor BB-factor, properdinC3 proacceleratorC3 proactivatorC3/C5 convertaseglycine-rich beta-glycoproteinproperdin factor BT-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69
Modification date2020032720200313
UniProtAcc

P00751

P48643

Ensembl transtripts involved in fusion geneENST00000556679, ENST00000456570, 
ENST00000477310, ENST00000425368, 
ENST00000497841, ENST00000417261, 
ENST00000427888, ENST00000459734, 
ENST00000455591, ENST00000433503, 
ENST00000474621, ENST00000424727, 
ENST00000436692, ENST00000473139, 
ENST00000399981, ENST00000419920, 
ENST00000465211, ENST00000375455, 
ENST00000489605, ENST00000426239, 
ENST00000419411, ENST00000460958, 
ENST00000280326, ENST00000503026, 
ENST00000515390, ENST00000515676, 
ENST00000506600, 
Fusion gene scores* DoF score10 X 8 X 4=32058 X 14 X 17=13804
# samples 1261
** MAII scorelog2(12/320*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(61/13804*10)=-4.50013332598527
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CFB [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCFB(31919861)-CCT5(10250033), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CFB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-EP-A3JL-01ACFBchr6

31919861

-CCT5chr5

10250033

+


Top

Fusion Gene ORF analysis for CFB-CCT5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000556679ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000556679ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000556679ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000556679ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000556679ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000456570ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000456570ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000456570ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000456570ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000456570ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000477310ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000477310ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000477310ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000477310ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000477310ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
In-frameENST00000425368ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
5CDS-intronENST00000425368ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
5CDS-intronENST00000425368ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
5CDS-intronENST00000425368ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
5CDS-intronENST00000425368ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000497841ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000497841ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000497841ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000497841ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000497841ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000417261ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000417261ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000417261ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000417261ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000417261ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000427888ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000427888ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000427888ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000427888ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000427888ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000459734ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000459734ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000459734ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000459734ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000459734ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000455591ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000455591ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000455591ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000455591ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000455591ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000433503ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000433503ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000433503ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000433503ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000433503ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000474621ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000474621ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000474621ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000474621ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000474621ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000424727ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000424727ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000424727ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000424727ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000424727ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000436692ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000436692ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000436692ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000436692ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000436692ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000473139ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000473139ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000473139ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000473139ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000473139ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000399981ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000399981ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000399981ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000399981ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000399981ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000419920ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000419920ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000419920ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000419920ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000419920ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000465211ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000465211ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000465211ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000465211ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000465211ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000375455ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000375455ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000375455ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000375455ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000375455ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000489605ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000489605ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000489605ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000489605ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000489605ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000426239ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000426239ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000426239ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000426239ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000426239ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000419411ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000419411ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000419411ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000419411ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000419411ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+
intron-3CDSENST00000460958ENST00000280326CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000460958ENST00000503026CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000460958ENST00000515390CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000460958ENST00000515676CFBchr6

31919861

-CCT5chr5

10250033

+
intron-intronENST00000460958ENST00000506600CFBchr6

31919861

-CCT5chr5

10250033

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000425368CFBchr631919861-ENST00000280326CCT5chr510250033+653728624262807793

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000425368ENST00000280326CFBchr631919861-CCT5chr510250033+0.0011118340.9988882

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Fusion Genomic Features for CFB-CCT5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CFB-CCT5


check button Go to

FGviewer for the breakpoints of chr6:31919861-chr5:10250033

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CFB

P00751

CCT5

P48643

FUNCTION: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCFBchr6:31919861chr5:10250033ENST00000425368-1818101_160783.0765.0DomainSushi 2
HgeneCFBchr6:31919861chr5:10250033ENST00000425368-1818163_220783.0765.0DomainSushi 3
HgeneCFBchr6:31919861chr5:10250033ENST00000425368-1818270_469783.0765.0DomainVWFA
HgeneCFBchr6:31919861chr5:10250033ENST00000425368-181835_100783.0765.0DomainSushi 1
HgeneCFBchr6:31919861chr5:10250033ENST00000425368-1818477_757783.0765.0DomainPeptidase S1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCFBchr6:31919861chr5:10250033ENST00000399981-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31919861chr5:10250033ENST00000399981-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31919861chr5:10250033ENST00000399981-119270_4690765.0DomainVWFA
HgeneCFBchr6:31919861chr5:10250033ENST00000399981-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31919861chr5:10250033ENST00000399981-119477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919861chr5:10250033ENST00000417261-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31919861chr5:10250033ENST00000417261-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31919861chr5:10250033ENST00000417261-119270_4690765.0DomainVWFA
HgeneCFBchr6:31919861chr5:10250033ENST00000417261-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31919861chr5:10250033ENST00000417261-119477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919861chr5:10250033ENST00000419411-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31919861chr5:10250033ENST00000419411-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31919861chr5:10250033ENST00000419411-118270_4690765.0DomainVWFA
HgeneCFBchr6:31919861chr5:10250033ENST00000419411-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31919861chr5:10250033ENST00000419411-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919861chr5:10250033ENST00000419920-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31919861chr5:10250033ENST00000419920-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31919861chr5:10250033ENST00000419920-118270_4690765.0DomainVWFA
HgeneCFBchr6:31919861chr5:10250033ENST00000419920-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31919861chr5:10250033ENST00000419920-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919861chr5:10250033ENST00000424727-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31919861chr5:10250033ENST00000424727-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31919861chr5:10250033ENST00000424727-119270_4690765.0DomainVWFA
HgeneCFBchr6:31919861chr5:10250033ENST00000424727-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31919861chr5:10250033ENST00000424727-119477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919861chr5:10250033ENST00000426239-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31919861chr5:10250033ENST00000426239-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31919861chr5:10250033ENST00000426239-119270_4690765.0DomainVWFA
HgeneCFBchr6:31919861chr5:10250033ENST00000426239-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31919861chr5:10250033ENST00000426239-119477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919861chr5:10250033ENST00000427888-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31919861chr5:10250033ENST00000427888-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31919861chr5:10250033ENST00000427888-118270_4690765.0DomainVWFA
HgeneCFBchr6:31919861chr5:10250033ENST00000427888-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31919861chr5:10250033ENST00000427888-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919861chr5:10250033ENST00000433503-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31919861chr5:10250033ENST00000433503-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31919861chr5:10250033ENST00000433503-118270_4690765.0DomainVWFA
HgeneCFBchr6:31919861chr5:10250033ENST00000433503-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31919861chr5:10250033ENST00000433503-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919861chr5:10250033ENST00000436692-118101_1600765.0DomainSushi 2
HgeneCFBchr6:31919861chr5:10250033ENST00000436692-118163_2200765.0DomainSushi 3
HgeneCFBchr6:31919861chr5:10250033ENST00000436692-118270_4690765.0DomainVWFA
HgeneCFBchr6:31919861chr5:10250033ENST00000436692-11835_1000765.0DomainSushi 1
HgeneCFBchr6:31919861chr5:10250033ENST00000436692-118477_7570765.0DomainPeptidase S1
HgeneCFBchr6:31919861chr5:10250033ENST00000455591-119101_1600765.0DomainSushi 2
HgeneCFBchr6:31919861chr5:10250033ENST00000455591-119163_2200765.0DomainSushi 3
HgeneCFBchr6:31919861chr5:10250033ENST00000455591-119270_4690765.0DomainVWFA
HgeneCFBchr6:31919861chr5:10250033ENST00000455591-11935_1000765.0DomainSushi 1
HgeneCFBchr6:31919861chr5:10250033ENST00000455591-119477_7570765.0DomainPeptidase S1


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Fusion Gene Sequence for CFB-CCT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000425368_ENST00000280326_TCGA-EP-A3JL-01A_CFB_chr6_31919861_-_CCT5_chr5_10250033_length(transcript)=6537nt_BP=2862nt
GGCCTTGGGGGAGGGGGAGGCCAGAATGACTCCAAGAGCTACAGGAAGGCAGGTCAGAGACCCCACTGGACAAACAGTGGCTGGACTCTG
CACCATAACACACAATCAACAGGGGAGTGAGCTGGATCCTTATTTCTGGTCCCTAAGTGGGTGGTTTGGGCTTACTGGGGAGGAGCTAAG
GCCGGAGAGGAGGTACTGAAGGGGAGAGTCCTGGACCTTTGGCAGCAAAGGGTGGGACTTCTGCAGTTTCTGTTTCCTTGACTGGCAGCT
CAGCGGGGCCCTCCCGCTTGGATGTTCCGGGAAAGTGATGTGGGTAGGACAGGCGGGGCGAGCCGCAGGTGCCAGAACACAGATTGTATA
AAAGGCTGGGGGCTGGTGGGGAGCAGGGGAAGGGAATGTGACCAGGTCTAGGTCTGGAGTTTCAGCTTGGACACTGAGCCAAGCAGACAA
GCAAAGCAAGCCAGGACACACCATCCTGCCCCAGGCCCAGCTTCTCTCCTGCCTTCCAACGCCATGGGGAGCAATCTCAGCCCCCAACTC
TGCCTGATGCCCTTTATCTTGGGCCTCTTGTCTGGAGGTGTGACCACCACTCCATGGTCTTTGGCCCGGCCCCAGGGATCCTGCTCTCTG
GAGGGGGTAGAGATCAAAGGCGGCTCCTTCCGACTTCTCCAAGAGGGCCAGGCACTGGAGTACGTGTGTCCTTCTGGCTTCTACCCGTAC
CCTGTGCAGACACGTACCTGCAGATCTACGGGGTCCTGGAGCACCCTGAAGACTCAAGACCAAAAGACTGTCAGGAAGGCAGAGTGCAGA
GCAATCCACTGTCCAAGACCACACGACTTCGAGAACGGGGAATACTGGCCCCGGTCTCCCTACTACAATGTGAGTGATGAGATCTCTTTC
CACTGCTATGACGGTTACACTCTCCGGGGCTCTGCCAATCGCACCTGCCAAGTGAATGGCCGATGGAGTGGGCAGACAGCGATCTGTGAC
AACGGAGCGGGGTACTGCTCCAACCCGGGCATCCCCATTGGCACAAGGAAGGTGGGCAGCCAGTACCGCCTTGAAGACAGCGTCACCTAC
CACTGCAGCCGGGGGCTTACCCTGCGTGGCTCCCAGCGGCGAACGTGTCAGGAAGGTGGCTCTTGGAGCGGGACGGAGCCTTCCTGCCAA
GACTCCTTCATGTACGACACCCCTCAAGAGGTGGCCGAAGCTTTCCTGTCTTCCCTGACAGAGACCATAGAAGGAGTCGATGCTGAGGAT
GGGCACGGCCCAGGGGAACAACAGAAGCGGAAGATCGTCCTGGACCCTTCAGGCTCCATGAACATCTACCTGGTGCTAGATGGATCAGAC
AGCATTGGGGCCAGCAACTTCACAGGAGCCAAAAAGTGTCTAGTCAACTTAATTGAGAAGGTGGCAAGTTATGGTGTGAAGCCAAGATAT
GGTCTAGTGACATATGCCACATACCCCAAAATTTGGGTCAAAGTGTCTGAAGCAGACAGCAGTAATGCAGACTGGGTCACGAAGCAGCTC
AATGAAATCAATTATGAAGACCACAAGTTGAAGTCAGGGACTAACACCAAGAAGGCCCTCCAGGCAGTGTACAGCATGATGAGCTGGCCA
GATGACGTCCCTCCTGAAGGCTGGAACCGCACCCGCCATGTCATCATCCTCATGACTGATGGATTGCACAACATGGGCGGGGACCCAATT
ACTGTCATTGATGAGATCCGGGACTTGCTATACATTGGCAAGGATCGCAAAAACCCAAGGGAGGATTATCTGGATGTCTATGTGTTTGGG
GTCGGGCCTTTGGTGAACCAAGTGAACATCAATGCTTTGGCTTCCAAGAAAGACAATGAGCAACATGTGTTCAAAGTCAAGGATATGGAA
AACCTGGAAGATGTTTTCTACCAAATGATCGATGAAAGCCAGTCTCTGAGTCTCTGTGGCATGGTTTGGGAACACAGGAAGGGTACCGAT
TACCACAAGCAACCATGGCAGGCCAAGATCTCAGTCATTCGCCCTTCAAAGGGACACGAGAGCTGTATGGGGGCTGTGGTGTCTGAGTAC
TTTGTGCTGACAGCAGCACATTGTTTCACTGTGGATGACAAGGAACACTCAATCAAGGTCAGCGTAGGAGGGGAGAAGCGGGACCTGGAG
ATAGAAGTAGTCCTATTTCACCCCAACTACAACATTAATGGGAAAAAAGAAGCAGGAATTCCTGAATTTTATGACTATGACGTTGCCCTG
ATCAAGCTCAAGAATAAGCTGAAATATGGCCAGACTATCAGGCCCATTTGTCTCCCCTGCACCGAGGGAACAACTCGAGCTTTGAGGCTT
CCTCCAACTACCACTTGCCAGCAACAAAAGGAAGAGCTGCTCCCTGCACAGGATATCAAAGCTCTGTTTGTGTCTGAGGAGGAGAAAAAG
CTGACTCGGAAGGAGGTCTACATCAAGAATGGGGATAAGAAAGGCAGCTGTGAGAGAGATGCTCAATATGCCCCAGGCTATGACAAAGTC
AAGGACATCTCAGAGGTGGTCACCCCTCGGTTCCTTTGTACTGGAGGAGTGAGTCCCTATGCTGACCCCAATACTTGCAGAGGTGATTCT
GGCGGCCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGTAGTGGATGTCTGCAAAAACCAGAAG
CGGCAAAAGCAGGTACCTGCTCACGCCCGAGACTTTCACATCAACCTCTTTCAAGTGCTGCCCTGGCTGAAGGAGAAACTCCAAGATGAG
GATTTGGGTTTTCTATAAGGGGTTTCCTGCTGGACAGGGGCGTGGGATTGAATTAAAACAGCTGCGACAACAAAAAAAAAAAAAAACCGG
AAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTA
TCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTC
AAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAG
TAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGC
GGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTC
CTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAAT
ACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAGGATGGAGATGTGACTGTAACTAATGATGGGGCCACC
ATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGATGAAATTGGAGATGGAACC
ACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTCACCCAATCAGAATAGCCGATGGC
TATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACATAAAGGACACCGAACCCCTGATT
CAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTA
GCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAG
GGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTGCAATTCTCACATGTCCATTTGAA
CCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAA
GAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCAG
AACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCA
GAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCAG
TGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTG
TGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAG
GCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGT
GGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAG
GGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCAACACAAATGGTTAGAATG
ATTTTGAAGATTGATGACATTCGTAAGCCTGGAGAATCTGAAGAATGAAGACATTGAGAAAACTATGTAGCAAGATCCACTTCTGTGATT
AAGTAAATGGATGTCTCGTGATGCATCTACAGTTATTTATTGTTACATCCTTTTCCAGACACTGTAGATGCTATAATAAAAATAGCTGTT
TGGTAACCATAGTTTCACTTGTTCAAAGCTGTGTAATCGTGGGGGTACCATCTCAACTGCTTTTGTATTCATTGTATTAAAAGAATCTGT
TTAAACAACCTTTATCTTCTCTTCGGGTTTAAGAAACGTTTATTGTAACAGTAATTAAATGCTGCCTTAATTGAAGGGGTTTGGGTGGAT
TTTTTTTTCTCAAAATAAGCTGTAGGGACTATTTTAACAGCTTAAACAGGAGCTCTCAAGATGCACTTTCATATTGAGAGGAATATGGGC
TTGATCCTCTTCCTATCTAAATGGGTGGGCCATTTGATTGTAGAGGGTCCACCACAGAATTATGGGATGCCTTAAGTGCTGTTACTAGGT
TGCTCACAGCCTAACCTGGCGTGTTGTTTAGGGCTGATGGAGACCCATGTGAGCCTTTGCTTTCCTCTGGCCCCGGCCCCACCCTGAACA
CAGCTCATACACAGAATCAGGACCAGCATGTGCAGAGCTGGCCACCAGCACAGGCTTAGGGCAGTTCAGAACCCACTTGTTTCCCTATCA
GAGGGACACAGTGAAGTGGAGGTTAAAGTAAATTACAGGAAATAAGGGAGAAATCTTGCAGTTACCATGTTCAGATAGAGTGACTGAAAT
TAATTGTACTTACTAAAGTATTAACTAGCTAACAGTGATGGGCCAAGACGCTCCGAGAACTCTACCGGGATTGTCTGTTCTGACAACCCA
GTGAGGCAGATACACTTTCTTACTGCTCACATCTTACAGGTGAGTACTCATAATTGGCCAGCATCTCACCACCAGCAAGTAGTAGGGCCA
GGTCAATCCCAGGCAGTCTGACCCCAGAGTGGCCCAGCTCATCCCCTACTCTGTTATTTGCTTGTTAATGATTCTCTAGATTTTCTAAAA
TAATGTTTCTTAGCATTGTGATGATAAAGCTCATGATGAACTTTATCACTAGTTATGCCACCTTAACTAGTCAGATTTCCTAGAATTAGG
AAATGGTGACTCTTGTCTAAATTTGGTTAAGTGATGAATTTGGGTTACCGTCTCATGTGAACCTGGAGATTCACCAGTCTTAACTTTTGG
GTCATTGTGTTTTCTCTACATTCATGCATTGGATGTTTTGCTAAATAACTCCTGTGGATTTAGGAATGTGTGCTAATAGCAATCTTCCTA
ATTTTCATGTTTATATGGAACTATGCAGTTGAGTATTGAAAGCTTTAAACTGAGTTTATTTACAAGGACTGAGTCTAGCCTACAGAGAAC
ATACAGCAGCCTTCTTTGGACCACAGTCTTATCCGAGGGGTCTGTGGTTGTATCAGAAGAGCCACTAAACCAATCCCCCTTTCCAAAATT
GAACCTCACAGACGTTCCTGTTTTTTGTGATTGAGAAACTGGTCAATGAACAGGAAGACTTAGAGATGTTTCACAAGCCTTTGATTTTTG

>In-frame_ENST00000425368_ENST00000280326_TCGA-EP-A3JL-01A_CFB_chr6_31919861_-_CCT5_chr5_10250033_length(amino acids)=793AA_start in transcript=426_stop in transcript=2807
MDTEPSRQAKQARTHHPAPGPASLLPSNAMGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEYV
CPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRW
SGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTET
IEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSEADSSN
ADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPRED
YLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGHESC
MGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTE
GTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYAD

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Fusion Gene PPI Analysis for CFB-CCT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CFB-CCT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCFBP00751DB01593ZincSmall moleculeApproved|Investigational
HgeneCFBP00751DB01593ZincSmall moleculeApproved|Investigational
HgeneCFBP00751DB01593ZincSmall moleculeApproved|Investigational
HgeneCFBP00751DB14487Zinc acetateSmall moleculeApproved|Investigational
HgeneCFBP00751DB14487Zinc acetateSmall moleculeApproved|Investigational
HgeneCFBP00751DB14487Zinc acetateSmall moleculeApproved|Investigational

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Related Diseases for CFB-CCT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCFBC2752038HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 45GENOMICS_ENGLAND;UNIPROT
HgeneCFBC2931788Atypical Hemolytic Uremic Syndrome3CTD_human;GENOMICS_ENGLAND
HgeneCFBC0017662Glomerulonephritis, Membranoproliferative1GENOMICS_ENGLAND
HgeneCFBC0019061Hemolytic-Uremic Syndrome1GENOMICS_ENGLAND
HgeneCFBC0024141Lupus Erythematosus, Systemic1CTD_human
HgeneCFBC0026896Myasthenia Gravis1CTD_human
HgeneCFBC0242380Libman-Sacks Disease1CTD_human
HgeneCFBC0242383Age related macular degeneration1CTD_human;GENOMICS_ENGLAND
HgeneCFBC0272242Complement deficiency disease1GENOMICS_ENGLAND
HgeneCFBC0751339Myasthenia Gravis, Generalized1CTD_human
HgeneCFBC0751340Myasthenia Gravis, Ocular1CTD_human
HgeneCFBC3809950COMPLEMENT FACTOR B DEFICIENCY1CTD_human;GENOMICS_ENGLAND
HgeneCFBC4087273C3 glomerulopathy1GENOMICS_ENGLAND
TgeneCCT5C1850395Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCCT5C0006142Malignant neoplasm of breast1CTD_human
TgeneCCT5C0019193Hepatitis, Toxic1CTD_human
TgeneCCT5C0019693HIV Infections1CTD_human
TgeneCCT5C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneCCT5C0678222Breast Carcinoma1CTD_human
TgeneCCT5C0860207Drug-Induced Liver Disease1CTD_human
TgeneCCT5C1257931Mammary Neoplasms, Human1CTD_human
TgeneCCT5C1262760Hepatitis, Drug-Induced1CTD_human
TgeneCCT5C1458155Mammary Neoplasms1CTD_human
TgeneCCT5C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneCCT5C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneCCT5C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneCCT5C4505456HIV Coinfection1CTD_human
TgeneCCT5C4704874Mammary Carcinoma, Human1CTD_human