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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHCHD7-PLAG1 (FusionGDB2 ID:16294)

Fusion Gene Summary for CHCHD7-PLAG1

check button Fusion gene summary
Fusion gene informationFusion gene name: CHCHD7-PLAG1
Fusion gene ID: 16294
HgeneTgene
Gene symbol

CHCHD7

PLAG1

Gene ID

79145

5324

Gene namecoiled-coil-helix-coiled-coil-helix domain containing 7PLAG1 zinc finger
SynonymsCOX23PSA|SGPA|ZNF912
Cytomap

8q12.1

8q12.1

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil-helix-coiled-coil-helix domain-containing protein 7COX23 cytochrome c oxidase assembly homologzinc finger protein PLAG1COL1A2/PLAG1 fusionHAS2/PLAG1 fusionpleiomorphic adenoma gene 1
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000521831, ENST00000355315, 
ENST00000303759, ENST00000517933, 
ENST00000518801, ENST00000523975, 
ENST00000396723, ENST00000523061, 
ENST00000521524, ENST00000519367, 
ENST00000316981, ENST00000423799, 
ENST00000429357, ENST00000519027, 
Fusion gene scores* DoF score3 X 4 X 4=4813 X 16 X 7=1456
# samples 59
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/1456*10)=-4.01594154386902
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHCHD7 [Title/Abstract] AND PLAG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHCHD7(57124398)-PLAG1(57080745), # samples:1
CHCHD7(57124398)-PLAG1(57092074), # samples:1
CHCHD7(57124396)-PLAG1(57083750), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLAG1

GO:0045944

positive regulation of transcription by RNA polymerase II

10646861


check buttonFusion gene breakpoints across CHCHD7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PLAG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4adenomaDQ478931CHCHD7chr8

57124398

PLAG1chr8

57080745

ChiTaRS5.0N/ADQ478931CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
ChiTaRS5.0N/ADQ478932CHCHD7chr8

57124396

+PLAG1chr8

57083750

-


Top

Fusion Gene ORF analysis for CHCHD7-PLAG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000521831ENST00000316981CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000521831ENST00000423799CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000521831ENST00000429357CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000521831ENST00000519027CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-3CDSENST00000355315ENST00000316981CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000355315ENST00000423799CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000355315ENST00000429357CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000355315ENST00000519027CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-3CDSENST00000303759ENST00000316981CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000303759ENST00000423799CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000303759ENST00000429357CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000303759ENST00000519027CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-3CDSENST00000517933ENST00000316981CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000517933ENST00000423799CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000517933ENST00000429357CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000517933ENST00000519027CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-3CDSENST00000518801ENST00000316981CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000518801ENST00000423799CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000518801ENST00000429357CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000518801ENST00000519027CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-3CDSENST00000523975ENST00000316981CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000523975ENST00000423799CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000523975ENST00000429357CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000523975ENST00000519027CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-3CDSENST00000396723ENST00000316981CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000396723ENST00000423799CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000396723ENST00000429357CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000396723ENST00000519027CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-3CDSENST00000523061ENST00000316981CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000523061ENST00000423799CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000523061ENST00000429357CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000523061ENST00000519027CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-3CDSENST00000521524ENST00000316981CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000521524ENST00000423799CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000521524ENST00000429357CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-intronENST00000521524ENST00000519027CHCHD7chr8

57124398

PLAG1chr8

57080745

intron-3CDSENST00000519367ENST00000316981CHCHD7chr8

57124398

PLAG1chr8

57080745

intron-intronENST00000519367ENST00000423799CHCHD7chr8

57124398

PLAG1chr8

57080745

intron-intronENST00000519367ENST00000429357CHCHD7chr8

57124398

PLAG1chr8

57080745

intron-intronENST00000519367ENST00000519027CHCHD7chr8

57124398

PLAG1chr8

57080745

5UTR-5UTRENST00000521831ENST00000316981CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000521831ENST00000423799CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000521831ENST00000429357CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000521831ENST00000519027CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-5UTRENST00000355315ENST00000316981CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000355315ENST00000423799CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000355315ENST00000429357CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000355315ENST00000519027CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-5UTRENST00000303759ENST00000316981CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000303759ENST00000423799CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000303759ENST00000429357CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000303759ENST00000519027CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-5UTRENST00000517933ENST00000316981CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000517933ENST00000423799CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000517933ENST00000429357CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000517933ENST00000519027CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-5UTRENST00000518801ENST00000316981CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000518801ENST00000423799CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000518801ENST00000429357CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000518801ENST00000519027CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-5UTRENST00000523975ENST00000316981CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000523975ENST00000423799CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000523975ENST00000429357CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000523975ENST00000519027CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-5UTRENST00000396723ENST00000316981CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000396723ENST00000423799CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000396723ENST00000429357CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000396723ENST00000519027CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-5UTRENST00000523061ENST00000316981CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000523061ENST00000423799CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000523061ENST00000429357CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000523061ENST00000519027CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-5UTRENST00000521524ENST00000316981CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000521524ENST00000423799CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000521524ENST00000429357CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-intronENST00000521524ENST00000519027CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
intron-5UTRENST00000519367ENST00000316981CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
intron-intronENST00000519367ENST00000423799CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
intron-intronENST00000519367ENST00000429357CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
intron-intronENST00000519367ENST00000519027CHCHD7chr8

57124398

+PLAG1chr8

57092074

-
5UTR-5UTRENST00000521831ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000521831ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000521831ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-intronENST00000521831ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000355315ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000355315ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000355315ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-intronENST00000355315ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000303759ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000303759ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000303759ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-intronENST00000303759ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000517933ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000517933ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000517933ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-intronENST00000517933ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000518801ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000518801ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000518801ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-intronENST00000518801ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000523975ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000523975ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000523975ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-intronENST00000523975ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000396723ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000396723ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000396723ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-intronENST00000396723ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000523061ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000523061ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000523061ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-intronENST00000523061ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000521524ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000521524ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-5UTRENST00000521524ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5UTR-intronENST00000521524ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
intron-5UTRENST00000519367ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
intron-5UTRENST00000519367ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
intron-5UTRENST00000519367ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
intron-intronENST00000519367ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57083750

-
5CDS-5UTRENST00000303759ENST00000316981CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
5CDS-5UTRENST00000303759ENST00000423799CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
5CDS-5UTRENST00000303759ENST00000429357CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
5CDS-5UTRENST00000396723ENST00000316981CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
5CDS-5UTRENST00000396723ENST00000423799CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
5CDS-5UTRENST00000396723ENST00000429357CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
5CDS-intronENST00000303759ENST00000519027CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
5CDS-intronENST00000396723ENST00000519027CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
5UTR-3CDSENST00000303759ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-3CDSENST00000355315ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-3CDSENST00000396723ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-3CDSENST00000517933ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-3CDSENST00000518801ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-3CDSENST00000521524ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-3CDSENST00000521831ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-3CDSENST00000523061ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-3CDSENST00000523975ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000303759ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000303759ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000303759ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000355315ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000355315ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000355315ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000396723ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000396723ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000396723ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000517933ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000517933ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000517933ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000518801ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000518801ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000518801ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
5UTR-intronENST00000521524ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57080745

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5UTR-intronENST00000521524ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57080745

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5UTR-intronENST00000521524ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57080745

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5UTR-intronENST00000521831ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57080745

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5UTR-intronENST00000521831ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57080745

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5UTR-intronENST00000521831ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57080745

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5UTR-intronENST00000523061ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57080745

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5UTR-intronENST00000523061ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57080745

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5UTR-intronENST00000523061ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57080745

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5UTR-intronENST00000523975ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57080745

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5UTR-intronENST00000523975ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57080745

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5UTR-intronENST00000523975ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57080745

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intron-3CDSENST00000519367ENST00000316981CHCHD7chr8

57124396

+PLAG1chr8

57080745

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intron-5UTRENST00000355315ENST00000316981CHCHD7chr8

57125468

+PLAG1chr8

57083748

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intron-5UTRENST00000355315ENST00000423799CHCHD7chr8

57125468

+PLAG1chr8

57083748

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intron-5UTRENST00000355315ENST00000429357CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000517933ENST00000316981CHCHD7chr8

57125468

+PLAG1chr8

57083748

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intron-5UTRENST00000517933ENST00000423799CHCHD7chr8

57125468

+PLAG1chr8

57083748

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intron-5UTRENST00000517933ENST00000429357CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000518801ENST00000316981CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000518801ENST00000423799CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000518801ENST00000429357CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000519367ENST00000316981CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000519367ENST00000423799CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000519367ENST00000429357CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000521524ENST00000316981CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000521524ENST00000423799CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000521524ENST00000429357CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000521831ENST00000316981CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000521831ENST00000423799CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000521831ENST00000429357CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000523061ENST00000316981CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000523061ENST00000423799CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000523061ENST00000429357CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000523975ENST00000316981CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000523975ENST00000423799CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-5UTRENST00000523975ENST00000429357CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-intronENST00000355315ENST00000519027CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-intronENST00000517933ENST00000519027CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-intronENST00000518801ENST00000519027CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-intronENST00000519367ENST00000423799CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
intron-intronENST00000519367ENST00000429357CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
intron-intronENST00000519367ENST00000519027CHCHD7chr8

57124396

+PLAG1chr8

57080745

-
intron-intronENST00000519367ENST00000519027CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-intronENST00000521524ENST00000519027CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-intronENST00000521831ENST00000519027CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-intronENST00000523061ENST00000519027CHCHD7chr8

57125468

+PLAG1chr8

57083748

-
intron-intronENST00000523975ENST00000519027CHCHD7chr8

57125468

+PLAG1chr8

57083748

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CHCHD7-PLAG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHCHD7-PLAG1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CHCHD7-PLAG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CHCHD7-PLAG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHCHD7-PLAG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHCHD7-PLAG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePLAG1C1519176Salivary Gland Pleomorphic Adenoma2CTD_human;ORPHANET
TgenePLAG1C0175693Russell-Silver syndrome1GENOMICS_ENGLAND
TgenePLAG1C0334475Lipoblastomatosis1CTD_human
TgenePLAG1C0473935Radiolabeled somatostatin analog study1GENOMICS_ENGLAND
TgenePLAG1C0796160MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE1GENOMICS_ENGLAND
TgenePLAG1C1260965Lipoblastoma1CTD_human