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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHD8-TOX4 (FusionGDB2 ID:16428)

Fusion Gene Summary for CHD8-TOX4

check button Fusion gene summary
Fusion gene informationFusion gene name: CHD8-TOX4
Fusion gene ID: 16428
HgeneTgene
Gene symbol

CHD8

TOX4

Gene ID

57680

9878

Gene namechromodomain helicase DNA binding protein 8TOX high mobility group box family member 4
SynonymsAUTS18|HELSNF1C14orf92|KIAA0737|LCP1|MIG7
Cytomap

14q11.2

14q11.2

Type of geneprotein-codingprotein-coding
Descriptionchromodomain-helicase-DNA-binding protein 8ATP-dependent helicase CHD8axis duplication inhibitorduplinhelicase with SNF2 domain 1TOX high mobility group box family member 4epidermal Langerhans cell protein LCP1migration-inducing protein 7
Modification date2020032920200313
UniProtAcc

Q9HCK8

.
Ensembl transtripts involved in fusion geneENST00000430710, ENST00000399982, 
ENST00000557364, ENST00000555962, 
ENST00000405508, ENST00000262709, 
ENST00000448790, ENST00000494242, 
Fusion gene scores* DoF score12 X 12 X 10=14406 X 9 X 4=216
# samples 189
** MAII scorelog2(18/1440*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHD8 [Title/Abstract] AND TOX4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHD8(21898960)-TOX4(21957332), # samples:3
Anticipated loss of major functional domain due to fusion event.CHD8-TOX4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CHD8-TOX4 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CHD8-TOX4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHD8

GO:0045893

positive regulation of transcription, DNA-templated

17938208

HgeneCHD8

GO:0090090

negative regulation of canonical Wnt signaling pathway

18378692|22083958


check buttonFusion gene breakpoints across CHD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TOX4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A128-01ACHD8chr14

21898960

-TOX4chr14

21957332

+
ChimerDB4LUSCTCGA-66-2786-01ACHD8chr14

21867761

-TOX4chr14

21955610

+
ChimerDB4BRCATCGA-AO-A128CHD8chr14

21898959

-TOX4chr14

21957331

+
ChimerDB4BRCATCGA-AO-A128-01ACHD8chr14

21898960

-TOX4chr14

21957332

+
ChimerDB4BRCATCGA-AO-A128-01ACHD8chr14

21899970

-TOX4chr14

21957332

+
ChimerDB4LUSCTCGA-66-2786CHD8chr14

21867761

-TOX4chr14

21944736

+
ChimerDB4BRCATCGA-AO-A128-01ACHD8chr14

21898960

-TOX4chr14

21957332

+


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Fusion Gene ORF analysis for CHD8-TOX4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000430710ENST00000405508CHD8chr14

21898960

-TOX4chr14

21957332

+
intron-3CDSENST00000430710ENST00000262709CHD8chr14

21898960

-TOX4chr14

21957332

+
intron-3CDSENST00000430710ENST00000448790CHD8chr14

21898960

-TOX4chr14

21957332

+
intron-intronENST00000430710ENST00000494242CHD8chr14

21898960

-TOX4chr14

21957332

+
In-frameENST00000399982ENST00000405508CHD8chr14

21898960

-TOX4chr14

21957332

+
In-frameENST00000399982ENST00000262709CHD8chr14

21898960

-TOX4chr14

21957332

+
In-frameENST00000399982ENST00000448790CHD8chr14

21898960

-TOX4chr14

21957332

+
5CDS-intronENST00000399982ENST00000494242CHD8chr14

21898960

-TOX4chr14

21957332

+
Frame-shiftENST00000557364ENST00000405508CHD8chr14

21898960

-TOX4chr14

21957332

+
Frame-shiftENST00000557364ENST00000262709CHD8chr14

21898960

-TOX4chr14

21957332

+
Frame-shiftENST00000557364ENST00000448790CHD8chr14

21898960

-TOX4chr14

21957332

+
5CDS-intronENST00000557364ENST00000494242CHD8chr14

21898960

-TOX4chr14

21957332

+
intron-3CDSENST00000555962ENST00000405508CHD8chr14

21898960

-TOX4chr14

21957332

+
intron-3CDSENST00000555962ENST00000262709CHD8chr14

21898960

-TOX4chr14

21957332

+
intron-3CDSENST00000555962ENST00000448790CHD8chr14

21898960

-TOX4chr14

21957332

+
intron-intronENST00000555962ENST00000494242CHD8chr14

21898960

-TOX4chr14

21957332

+
In-frameENST00000430710ENST00000405508CHD8chr14

21867761

-TOX4chr14

21955610

+
In-frameENST00000430710ENST00000262709CHD8chr14

21867761

-TOX4chr14

21955610

+
In-frameENST00000430710ENST00000448790CHD8chr14

21867761

-TOX4chr14

21955610

+
5CDS-3UTRENST00000430710ENST00000494242CHD8chr14

21867761

-TOX4chr14

21955610

+
Frame-shiftENST00000399982ENST00000405508CHD8chr14

21867761

-TOX4chr14

21955610

+
Frame-shiftENST00000399982ENST00000262709CHD8chr14

21867761

-TOX4chr14

21955610

+
Frame-shiftENST00000399982ENST00000448790CHD8chr14

21867761

-TOX4chr14

21955610

+
5CDS-3UTRENST00000399982ENST00000494242CHD8chr14

21867761

-TOX4chr14

21955610

+
Frame-shiftENST00000557364ENST00000405508CHD8chr14

21867761

-TOX4chr14

21955610

+
Frame-shiftENST00000557364ENST00000262709CHD8chr14

21867761

-TOX4chr14

21955610

+
Frame-shiftENST00000557364ENST00000448790CHD8chr14

21867761

-TOX4chr14

21955610

+
5CDS-3UTRENST00000557364ENST00000494242CHD8chr14

21867761

-TOX4chr14

21955610

+
5UTR-3CDSENST00000555962ENST00000405508CHD8chr14

21867761

-TOX4chr14

21955610

+
5UTR-3CDSENST00000555962ENST00000262709CHD8chr14

21867761

-TOX4chr14

21955610

+
5UTR-3CDSENST00000555962ENST00000448790CHD8chr14

21867761

-TOX4chr14

21955610

+
5UTR-3UTRENST00000555962ENST00000494242CHD8chr14

21867761

-TOX4chr14

21955610

+
intron-3CDSENST00000430710ENST00000405508CHD8chr14

21898959

-TOX4chr14

21957331

+
intron-3CDSENST00000430710ENST00000262709CHD8chr14

21898959

-TOX4chr14

21957331

+
intron-3CDSENST00000430710ENST00000448790CHD8chr14

21898959

-TOX4chr14

21957331

+
intron-intronENST00000430710ENST00000494242CHD8chr14

21898959

-TOX4chr14

21957331

+
In-frameENST00000399982ENST00000405508CHD8chr14

21898959

-TOX4chr14

21957331

+
In-frameENST00000399982ENST00000262709CHD8chr14

21898959

-TOX4chr14

21957331

+
In-frameENST00000399982ENST00000448790CHD8chr14

21898959

-TOX4chr14

21957331

+
5CDS-intronENST00000399982ENST00000494242CHD8chr14

21898959

-TOX4chr14

21957331

+
Frame-shiftENST00000557364ENST00000405508CHD8chr14

21898959

-TOX4chr14

21957331

+
Frame-shiftENST00000557364ENST00000262709CHD8chr14

21898959

-TOX4chr14

21957331

+
Frame-shiftENST00000557364ENST00000448790CHD8chr14

21898959

-TOX4chr14

21957331

+
5CDS-intronENST00000557364ENST00000494242CHD8chr14

21898959

-TOX4chr14

21957331

+
intron-3CDSENST00000555962ENST00000405508CHD8chr14

21898959

-TOX4chr14

21957331

+
intron-3CDSENST00000555962ENST00000262709CHD8chr14

21898959

-TOX4chr14

21957331

+
intron-3CDSENST00000555962ENST00000448790CHD8chr14

21898959

-TOX4chr14

21957331

+
intron-intronENST00000555962ENST00000494242CHD8chr14

21898959

-TOX4chr14

21957331

+
Frame-shiftENST00000430710ENST00000405508CHD8chr14

21899970

-TOX4chr14

21957332

+
Frame-shiftENST00000430710ENST00000262709CHD8chr14

21899970

-TOX4chr14

21957332

+
Frame-shiftENST00000430710ENST00000448790CHD8chr14

21899970

-TOX4chr14

21957332

+
5CDS-intronENST00000430710ENST00000494242CHD8chr14

21899970

-TOX4chr14

21957332

+
intron-3CDSENST00000399982ENST00000405508CHD8chr14

21899970

-TOX4chr14

21957332

+
intron-3CDSENST00000399982ENST00000262709CHD8chr14

21899970

-TOX4chr14

21957332

+
intron-3CDSENST00000399982ENST00000448790CHD8chr14

21899970

-TOX4chr14

21957332

+
intron-intronENST00000399982ENST00000494242CHD8chr14

21899970

-TOX4chr14

21957332

+
intron-3CDSENST00000557364ENST00000405508CHD8chr14

21899970

-TOX4chr14

21957332

+
intron-3CDSENST00000557364ENST00000262709CHD8chr14

21899970

-TOX4chr14

21957332

+
intron-3CDSENST00000557364ENST00000448790CHD8chr14

21899970

-TOX4chr14

21957332

+
intron-intronENST00000557364ENST00000494242CHD8chr14

21899970

-TOX4chr14

21957332

+
5UTR-3CDSENST00000555962ENST00000405508CHD8chr14

21899970

-TOX4chr14

21957332

+
5UTR-3CDSENST00000555962ENST00000262709CHD8chr14

21899970

-TOX4chr14

21957332

+
5UTR-3CDSENST00000555962ENST00000448790CHD8chr14

21899970

-TOX4chr14

21957332

+
5UTR-intronENST00000555962ENST00000494242CHD8chr14

21899970

-TOX4chr14

21957332

+
5CDS-intronENST00000430710ENST00000405508CHD8chr14

21867761

-TOX4chr14

21944736

+
5CDS-intronENST00000430710ENST00000262709CHD8chr14

21867761

-TOX4chr14

21944736

+
5CDS-intronENST00000430710ENST00000448790CHD8chr14

21867761

-TOX4chr14

21944736

+
5CDS-intronENST00000430710ENST00000494242CHD8chr14

21867761

-TOX4chr14

21944736

+
5CDS-intronENST00000399982ENST00000405508CHD8chr14

21867761

-TOX4chr14

21944736

+
5CDS-intronENST00000399982ENST00000262709CHD8chr14

21867761

-TOX4chr14

21944736

+
5CDS-intronENST00000399982ENST00000448790CHD8chr14

21867761

-TOX4chr14

21944736

+
5CDS-intronENST00000399982ENST00000494242CHD8chr14

21867761

-TOX4chr14

21944736

+
5CDS-intronENST00000557364ENST00000405508CHD8chr14

21867761

-TOX4chr14

21944736

+
5CDS-intronENST00000557364ENST00000262709CHD8chr14

21867761

-TOX4chr14

21944736

+
5CDS-intronENST00000557364ENST00000448790CHD8chr14

21867761

-TOX4chr14

21944736

+
5CDS-intronENST00000557364ENST00000494242CHD8chr14

21867761

-TOX4chr14

21944736

+
5UTR-intronENST00000555962ENST00000405508CHD8chr14

21867761

-TOX4chr14

21944736

+
5UTR-intronENST00000555962ENST00000262709CHD8chr14

21867761

-TOX4chr14

21944736

+
5UTR-intronENST00000555962ENST00000448790CHD8chr14

21867761

-TOX4chr14

21944736

+
5UTR-intronENST00000555962ENST00000494242CHD8chr14

21867761

-TOX4chr14

21944736

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CHD8-TOX4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CHD8chr1421899969-TOX4chr1421957331+0.0003066210.9996934
CHD8chr1421898959-TOX4chr1421957331+6.30E-070.9999994
CHD8chr1421898959-TOX4chr1421957331+6.30E-070.9999994
CHD8chr1421867760-TOX4chr1421955609+1.35E-070.9999999
CHD8chr1421899969-TOX4chr1421957331+0.0003066210.9996934
CHD8chr1421898959-TOX4chr1421957331+6.30E-070.9999994
CHD8chr1421898959-TOX4chr1421957331+6.30E-070.9999994
CHD8chr1421867760-TOX4chr1421955609+1.35E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHD8-TOX4


check button Go to

FGviewer for the breakpoints of chr14:21898960-chr14:21957332

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHD8

Q9HCK8

.
FUNCTION: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. {ECO:0000255|HAMAP-Rule:MF_03071, ECO:0000269|PubMed:17938208, ECO:0000269|PubMed:18378692}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD8chr14:21867761chr14:21955610ENST00000399982-2537292_4101640.33333333333332582.0Compositional biasGln-rich
HgeneCHD8chr14:21867761chr14:21955610ENST00000430710-2638292_4101361.33333333333332303.0Compositional biasGln-rich
HgeneCHD8chr14:21867761chr14:21955610ENST00000557364-2638292_4101640.33333333333332582.0Compositional biasGln-rich
HgeneCHD8chr14:21867761chr14:21955610ENST00000399982-25371137_12881640.33333333333332582.0DomainHelicase C-terminal
HgeneCHD8chr14:21867761chr14:21955610ENST00000399982-2537642_7091640.33333333333332582.0DomainChromo 1
HgeneCHD8chr14:21867761chr14:21955610ENST00000399982-2537724_7901640.33333333333332582.0DomainChromo 2
HgeneCHD8chr14:21867761chr14:21955610ENST00000399982-2537823_9971640.33333333333332582.0DomainHelicase ATP-binding
HgeneCHD8chr14:21867761chr14:21955610ENST00000430710-26381137_12881361.33333333333332303.0DomainHelicase C-terminal
HgeneCHD8chr14:21867761chr14:21955610ENST00000430710-2638642_7091361.33333333333332303.0DomainChromo 1
HgeneCHD8chr14:21867761chr14:21955610ENST00000430710-2638724_7901361.33333333333332303.0DomainChromo 2
HgeneCHD8chr14:21867761chr14:21955610ENST00000430710-2638823_9971361.33333333333332303.0DomainHelicase ATP-binding
HgeneCHD8chr14:21867761chr14:21955610ENST00000557364-26381137_12881640.33333333333332582.0DomainHelicase C-terminal
HgeneCHD8chr14:21867761chr14:21955610ENST00000557364-2638642_7091640.33333333333332582.0DomainChromo 1
HgeneCHD8chr14:21867761chr14:21955610ENST00000557364-2638724_7901640.33333333333332582.0DomainChromo 2
HgeneCHD8chr14:21867761chr14:21955610ENST00000557364-2638823_9971640.33333333333332582.0DomainHelicase ATP-binding
HgeneCHD8chr14:21867761chr14:21955610ENST00000399982-2537948_9511640.33333333333332582.0MotifDEAH box
HgeneCHD8chr14:21867761chr14:21955610ENST00000430710-2638948_9511361.33333333333332303.0MotifDEAH box
HgeneCHD8chr14:21867761chr14:21955610ENST00000557364-2638948_9511640.33333333333332582.0MotifDEAH box
HgeneCHD8chr14:21867761chr14:21955610ENST00000399982-2537836_8431640.33333333333332582.0Nucleotide bindingATP
HgeneCHD8chr14:21867761chr14:21955610ENST00000430710-2638836_8431361.33333333333332303.0Nucleotide bindingATP
HgeneCHD8chr14:21867761chr14:21955610ENST00000557364-2638836_8431640.33333333333332582.0Nucleotide bindingATP
TgeneTOX4chr14:21867761chr14:21955610ENST0000026270919401_53425.0622.0Compositional biasNote=Gln/Pro-rich
TgeneTOX4chr14:21867761chr14:21955610ENST0000026270919426_43425.0622.0Compositional biasNote=Poly-Ala
TgeneTOX4chr14:21867761chr14:21955610ENST00000405508210401_53425.0622.0Compositional biasNote=Gln/Pro-rich
TgeneTOX4chr14:21867761chr14:21955610ENST00000405508210426_43425.0622.0Compositional biasNote=Poly-Ala
TgeneTOX4chr14:21898959chr14:21957331ENST0000026270939401_534193.0622.0Compositional biasNote=Gln/Pro-rich
TgeneTOX4chr14:21898959chr14:21957331ENST0000026270939426_434193.0622.0Compositional biasNote=Poly-Ala
TgeneTOX4chr14:21898959chr14:21957331ENST00000405508410401_534193.0622.0Compositional biasNote=Gln/Pro-rich
TgeneTOX4chr14:21898959chr14:21957331ENST00000405508410426_434193.0622.0Compositional biasNote=Poly-Ala
TgeneTOX4chr14:21898960chr14:21957332ENST0000026270939401_534193.0622.0Compositional biasNote=Gln/Pro-rich
TgeneTOX4chr14:21898960chr14:21957332ENST0000026270939426_434193.0622.0Compositional biasNote=Poly-Ala
TgeneTOX4chr14:21898960chr14:21957332ENST00000405508410401_534193.0622.0Compositional biasNote=Gln/Pro-rich
TgeneTOX4chr14:21898960chr14:21957332ENST00000405508410426_434193.0622.0Compositional biasNote=Poly-Ala
TgeneTOX4chr14:21867761chr14:21955610ENST0000026270919223_29125.0622.0DNA bindingHMG box
TgeneTOX4chr14:21867761chr14:21955610ENST00000405508210223_29125.0622.0DNA bindingHMG box
TgeneTOX4chr14:21898959chr14:21957331ENST0000026270939223_291193.0622.0DNA bindingHMG box
TgeneTOX4chr14:21898959chr14:21957331ENST00000405508410223_291193.0622.0DNA bindingHMG box
TgeneTOX4chr14:21898960chr14:21957332ENST0000026270939223_291193.0622.0DNA bindingHMG box
TgeneTOX4chr14:21898960chr14:21957332ENST00000405508410223_291193.0622.0DNA bindingHMG box
TgeneTOX4chr14:21867761chr14:21955610ENST0000026270919213_21825.0622.0MotifNuclear localization signal
TgeneTOX4chr14:21867761chr14:21955610ENST00000405508210213_21825.0622.0MotifNuclear localization signal
TgeneTOX4chr14:21898959chr14:21957331ENST0000026270939213_218193.0622.0MotifNuclear localization signal
TgeneTOX4chr14:21898959chr14:21957331ENST00000405508410213_218193.0622.0MotifNuclear localization signal
TgeneTOX4chr14:21898960chr14:21957332ENST0000026270939213_218193.0622.0MotifNuclear localization signal
TgeneTOX4chr14:21898960chr14:21957332ENST00000405508410213_218193.0622.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD8chr14:21867761chr14:21955610ENST00000399982-25372069_20981640.33333333333332582.0Compositional biasSer-rich
HgeneCHD8chr14:21867761chr14:21955610ENST00000399982-25372493_25081640.33333333333332582.0Compositional biasHis-rich
HgeneCHD8chr14:21867761chr14:21955610ENST00000399982-25372539_25811640.33333333333332582.0Compositional biasAsp-rich
HgeneCHD8chr14:21867761chr14:21955610ENST00000430710-26382069_20981361.33333333333332303.0Compositional biasSer-rich
HgeneCHD8chr14:21867761chr14:21955610ENST00000430710-26382493_25081361.33333333333332303.0Compositional biasHis-rich
HgeneCHD8chr14:21867761chr14:21955610ENST00000430710-26382539_25811361.33333333333332303.0Compositional biasAsp-rich
HgeneCHD8chr14:21867761chr14:21955610ENST00000557364-26382069_20981640.33333333333332582.0Compositional biasSer-rich
HgeneCHD8chr14:21867761chr14:21955610ENST00000557364-26382493_25081640.33333333333332582.0Compositional biasHis-rich
HgeneCHD8chr14:21867761chr14:21955610ENST00000557364-26382539_25811640.33333333333332582.0Compositional biasAsp-rich
HgeneCHD8chr14:21898959chr14:21957331ENST00000399982-1372069_2098281.02582.0Compositional biasSer-rich
HgeneCHD8chr14:21898959chr14:21957331ENST00000399982-1372493_2508281.02582.0Compositional biasHis-rich
HgeneCHD8chr14:21898959chr14:21957331ENST00000399982-1372539_2581281.02582.0Compositional biasAsp-rich
HgeneCHD8chr14:21898959chr14:21957331ENST00000399982-137292_410281.02582.0Compositional biasGln-rich
HgeneCHD8chr14:21898959chr14:21957331ENST00000430710-1382069_209802303.0Compositional biasSer-rich
HgeneCHD8chr14:21898959chr14:21957331ENST00000430710-1382493_250802303.0Compositional biasHis-rich
HgeneCHD8chr14:21898959chr14:21957331ENST00000430710-1382539_258102303.0Compositional biasAsp-rich
HgeneCHD8chr14:21898959chr14:21957331ENST00000430710-138292_41002303.0Compositional biasGln-rich
HgeneCHD8chr14:21898959chr14:21957331ENST00000557364-2382069_2098281.02582.0Compositional biasSer-rich
HgeneCHD8chr14:21898959chr14:21957331ENST00000557364-2382493_2508281.02582.0Compositional biasHis-rich
HgeneCHD8chr14:21898959chr14:21957331ENST00000557364-2382539_2581281.02582.0Compositional biasAsp-rich
HgeneCHD8chr14:21898959chr14:21957331ENST00000557364-238292_410281.02582.0Compositional biasGln-rich
HgeneCHD8chr14:21898960chr14:21957332ENST00000399982-1372069_2098281.02582.0Compositional biasSer-rich
HgeneCHD8chr14:21898960chr14:21957332ENST00000399982-1372493_2508281.02582.0Compositional biasHis-rich
HgeneCHD8chr14:21898960chr14:21957332ENST00000399982-1372539_2581281.02582.0Compositional biasAsp-rich
HgeneCHD8chr14:21898960chr14:21957332ENST00000399982-137292_410281.02582.0Compositional biasGln-rich
HgeneCHD8chr14:21898960chr14:21957332ENST00000430710-1382069_209802303.0Compositional biasSer-rich
HgeneCHD8chr14:21898960chr14:21957332ENST00000430710-1382493_250802303.0Compositional biasHis-rich
HgeneCHD8chr14:21898960chr14:21957332ENST00000430710-1382539_258102303.0Compositional biasAsp-rich
HgeneCHD8chr14:21898960chr14:21957332ENST00000430710-138292_41002303.0Compositional biasGln-rich
HgeneCHD8chr14:21898960chr14:21957332ENST00000557364-2382069_2098281.02582.0Compositional biasSer-rich
HgeneCHD8chr14:21898960chr14:21957332ENST00000557364-2382493_2508281.02582.0Compositional biasHis-rich
HgeneCHD8chr14:21898960chr14:21957332ENST00000557364-2382539_2581281.02582.0Compositional biasAsp-rich
HgeneCHD8chr14:21898960chr14:21957332ENST00000557364-238292_410281.02582.0Compositional biasGln-rich
HgeneCHD8chr14:21898959chr14:21957331ENST00000399982-1371137_1288281.02582.0DomainHelicase C-terminal
HgeneCHD8chr14:21898959chr14:21957331ENST00000399982-137642_709281.02582.0DomainChromo 1
HgeneCHD8chr14:21898959chr14:21957331ENST00000399982-137724_790281.02582.0DomainChromo 2
HgeneCHD8chr14:21898959chr14:21957331ENST00000399982-137823_997281.02582.0DomainHelicase ATP-binding
HgeneCHD8chr14:21898959chr14:21957331ENST00000430710-1381137_128802303.0DomainHelicase C-terminal
HgeneCHD8chr14:21898959chr14:21957331ENST00000430710-138642_70902303.0DomainChromo 1
HgeneCHD8chr14:21898959chr14:21957331ENST00000430710-138724_79002303.0DomainChromo 2
HgeneCHD8chr14:21898959chr14:21957331ENST00000430710-138823_99702303.0DomainHelicase ATP-binding
HgeneCHD8chr14:21898959chr14:21957331ENST00000557364-2381137_1288281.02582.0DomainHelicase C-terminal
HgeneCHD8chr14:21898959chr14:21957331ENST00000557364-238642_709281.02582.0DomainChromo 1
HgeneCHD8chr14:21898959chr14:21957331ENST00000557364-238724_790281.02582.0DomainChromo 2
HgeneCHD8chr14:21898959chr14:21957331ENST00000557364-238823_997281.02582.0DomainHelicase ATP-binding
HgeneCHD8chr14:21898960chr14:21957332ENST00000399982-1371137_1288281.02582.0DomainHelicase C-terminal
HgeneCHD8chr14:21898960chr14:21957332ENST00000399982-137642_709281.02582.0DomainChromo 1
HgeneCHD8chr14:21898960chr14:21957332ENST00000399982-137724_790281.02582.0DomainChromo 2
HgeneCHD8chr14:21898960chr14:21957332ENST00000399982-137823_997281.02582.0DomainHelicase ATP-binding
HgeneCHD8chr14:21898960chr14:21957332ENST00000430710-1381137_128802303.0DomainHelicase C-terminal
HgeneCHD8chr14:21898960chr14:21957332ENST00000430710-138642_70902303.0DomainChromo 1
HgeneCHD8chr14:21898960chr14:21957332ENST00000430710-138724_79002303.0DomainChromo 2
HgeneCHD8chr14:21898960chr14:21957332ENST00000430710-138823_99702303.0DomainHelicase ATP-binding
HgeneCHD8chr14:21898960chr14:21957332ENST00000557364-2381137_1288281.02582.0DomainHelicase C-terminal
HgeneCHD8chr14:21898960chr14:21957332ENST00000557364-238642_709281.02582.0DomainChromo 1
HgeneCHD8chr14:21898960chr14:21957332ENST00000557364-238724_790281.02582.0DomainChromo 2
HgeneCHD8chr14:21898960chr14:21957332ENST00000557364-238823_997281.02582.0DomainHelicase ATP-binding
HgeneCHD8chr14:21898959chr14:21957331ENST00000399982-137948_951281.02582.0MotifDEAH box
HgeneCHD8chr14:21898959chr14:21957331ENST00000430710-138948_95102303.0MotifDEAH box
HgeneCHD8chr14:21898959chr14:21957331ENST00000557364-238948_951281.02582.0MotifDEAH box
HgeneCHD8chr14:21898960chr14:21957332ENST00000399982-137948_951281.02582.0MotifDEAH box
HgeneCHD8chr14:21898960chr14:21957332ENST00000430710-138948_95102303.0MotifDEAH box
HgeneCHD8chr14:21898960chr14:21957332ENST00000557364-238948_951281.02582.0MotifDEAH box
HgeneCHD8chr14:21898959chr14:21957331ENST00000399982-137836_843281.02582.0Nucleotide bindingATP
HgeneCHD8chr14:21898959chr14:21957331ENST00000430710-138836_84302303.0Nucleotide bindingATP
HgeneCHD8chr14:21898959chr14:21957331ENST00000557364-238836_843281.02582.0Nucleotide bindingATP
HgeneCHD8chr14:21898960chr14:21957332ENST00000399982-137836_843281.02582.0Nucleotide bindingATP
HgeneCHD8chr14:21898960chr14:21957332ENST00000430710-138836_84302303.0Nucleotide bindingATP
HgeneCHD8chr14:21898960chr14:21957332ENST00000557364-238836_843281.02582.0Nucleotide bindingATP


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Fusion Gene Sequence for CHD8-TOX4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CHD8-TOX4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCHD8chr14:21867761chr14:21955610ENST00000399982-25371789_23021640.33333333333332582.0FAM124B
HgeneCHD8chr14:21867761chr14:21955610ENST00000430710-26381789_23021361.33333333333332303.0FAM124B
HgeneCHD8chr14:21867761chr14:21955610ENST00000557364-26381789_23021640.33333333333332582.0FAM124B
HgeneCHD8chr14:21898959chr14:21957331ENST00000399982-1371789_2302281.02582.0FAM124B
HgeneCHD8chr14:21898959chr14:21957331ENST00000430710-1381789_230202303.0FAM124B
HgeneCHD8chr14:21898959chr14:21957331ENST00000557364-2381789_2302281.02582.0FAM124B
HgeneCHD8chr14:21898960chr14:21957332ENST00000399982-1371789_2302281.02582.0FAM124B
HgeneCHD8chr14:21898960chr14:21957332ENST00000430710-1381789_230202303.0FAM124B
HgeneCHD8chr14:21898960chr14:21957332ENST00000557364-2381789_2302281.02582.0FAM124B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHD8-TOX4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHD8-TOX4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHD8C1510586Autism Spectrum Disorders8CLINGEN;CTD_human
HgeneCHD8C3554373AUTISM, SUSCEPTIBILITY TO, 183GENOMICS_ENGLAND;UNIPROT
HgeneCHD8C0004352Autistic Disorder2CTD_human;GENOMICS_ENGLAND
HgeneCHD8C0221355Macrocephaly2CTD_human
HgeneCHD8C0017178Gastrointestinal Diseases1CTD_human
HgeneCHD8C0020796Profound Mental Retardation1CTD_human
HgeneCHD8C0025363Mental Retardation, Psychosocial1CTD_human
HgeneCHD8C0282631Facies1CTD_human
HgeneCHD8C0559031Functional Gastrointestinal Disorders1CTD_human
HgeneCHD8C0917816Mental deficiency1CTD_human
HgeneCHD8C1565321Cholera Infantum1CTD_human
HgeneCHD8C3714756Intellectual Disability1CTD_human