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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:CHEK2-THOC5 (FusionGDB2 ID:16451) |
Fusion Gene Summary for CHEK2-THOC5 |
Fusion gene summary |
Fusion gene information | Fusion gene name: CHEK2-THOC5 | Fusion gene ID: 16451 | Hgene | Tgene | Gene symbol | CHEK2 | THOC5 | Gene ID | 11200 | 8563 |
Gene name | checkpoint kinase 2 | THO complex 5 | |
Synonyms | CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1 | C22orf19|Fmip|PK1.3|fSAP79 | |
Cytomap | 22q12.1 | 22q12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase Chk2CHK2 checkpoint homologcds1 homologcheckpoint-like protein CHK2 | THO complex subunit 5 homologFms-interacting proteinNF2/meningioma region protein pK1.3PP39.2functional spliceosome-associated protein 79hTREX90placental protein 39.2 | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | O96017 | . | |
Ensembl transtripts involved in fusion gene | ENST00000382565, ENST00000382578, ENST00000382566, ENST00000348295, ENST00000544772, ENST00000404276, ENST00000328354, ENST00000405598, ENST00000382580, ENST00000402731, ENST00000403642, ENST00000464581, | ENST00000490103, ENST00000397871, ENST00000397872, ENST00000397873, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 6 X 4=144 |
# samples | 3 | 6 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CHEK2 [Title/Abstract] AND THOC5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CHEK2(29085123)-THOC5(29932727), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | CHEK2-THOC5 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. CHEK2-THOC5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. CHEK2-THOC5 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. CHEK2-THOC5 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CHEK2-THOC5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CHEK2 | GO:0006355 | regulation of transcription, DNA-templated | 12717439 |
Hgene | CHEK2 | GO:0006468 | protein phosphorylation | 12717439 |
Hgene | CHEK2 | GO:0006974 | cellular response to DNA damage stimulus | 24550317 |
Hgene | CHEK2 | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 12402044 |
Hgene | CHEK2 | GO:0042770 | signal transduction in response to DNA damage | 14744935 |
Hgene | CHEK2 | GO:0045893 | positive regulation of transcription, DNA-templated | 17101782 |
Hgene | CHEK2 | GO:0046777 | protein autophosphorylation | 16794575|18644861 |
Hgene | CHEK2 | GO:0050821 | protein stabilization | 12717439 |
Tgene | THOC5 | GO:0006406 | mRNA export from nucleus | 17190602 |
Tgene | THOC5 | GO:0030224 | monocyte differentiation | 19015024 |
Tgene | THOC5 | GO:0046784 | viral mRNA export from host cell nucleus | 18974867 |
Fusion gene breakpoints across CHEK2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across THOC5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | UCS | TCGA-NF-A4WX-01A | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
ChimerDB4 | UCS | TCGA-NF-A4WX | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
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Fusion Gene ORF analysis for CHEK2-THOC5 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000382565 | ENST00000490103 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000382565 | ENST00000397871 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000382565 | ENST00000397872 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000382565 | ENST00000397873 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000382578 | ENST00000490103 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000382578 | ENST00000397871 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000382578 | ENST00000397872 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000382578 | ENST00000397873 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
3UTR-3CDS | ENST00000382566 | ENST00000490103 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
3UTR-3CDS | ENST00000382566 | ENST00000397871 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
3UTR-3CDS | ENST00000382566 | ENST00000397872 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
3UTR-3CDS | ENST00000382566 | ENST00000397873 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000348295 | ENST00000490103 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000348295 | ENST00000397871 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000348295 | ENST00000397872 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000348295 | ENST00000397873 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
In-frame | ENST00000544772 | ENST00000490103 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
In-frame | ENST00000544772 | ENST00000397871 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
In-frame | ENST00000544772 | ENST00000397872 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
In-frame | ENST00000544772 | ENST00000397873 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000404276 | ENST00000490103 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000404276 | ENST00000397871 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000404276 | ENST00000397872 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000404276 | ENST00000397873 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000328354 | ENST00000490103 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000328354 | ENST00000397871 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000328354 | ENST00000397872 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000328354 | ENST00000397873 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000405598 | ENST00000490103 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000405598 | ENST00000397871 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000405598 | ENST00000397872 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000405598 | ENST00000397873 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000382580 | ENST00000490103 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000382580 | ENST00000397871 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000382580 | ENST00000397872 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000382580 | ENST00000397873 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000402731 | ENST00000490103 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000402731 | ENST00000397871 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000402731 | ENST00000397872 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000402731 | ENST00000397873 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000403642 | ENST00000490103 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000403642 | ENST00000397871 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000403642 | ENST00000397872 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
Frame-shift | ENST00000403642 | ENST00000397873 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
intron-3CDS | ENST00000464581 | ENST00000490103 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
intron-3CDS | ENST00000464581 | ENST00000397871 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
intron-3CDS | ENST00000464581 | ENST00000397872 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
intron-3CDS | ENST00000464581 | ENST00000397873 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000544772 | CHEK2 | chr22 | 29085123 | - | ENST00000490103 | THOC5 | chr22 | 29932727 | - | 6347 | 2316 | 2317 | 3768 | 483 |
ENST00000544772 | CHEK2 | chr22 | 29085123 | - | ENST00000397871 | THOC5 | chr22 | 29932727 | - | 4058 | 2316 | 2317 | 3768 | 483 |
ENST00000544772 | CHEK2 | chr22 | 29085123 | - | ENST00000397872 | THOC5 | chr22 | 29932727 | - | 4058 | 2316 | 2317 | 3768 | 483 |
ENST00000544772 | CHEK2 | chr22 | 29085123 | - | ENST00000397873 | THOC5 | chr22 | 29932727 | - | 3868 | 2316 | 2317 | 3768 | 483 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000544772 | ENST00000490103 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - | 0.000988825 | 0.99901116 |
ENST00000544772 | ENST00000397871 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - | 0.002415247 | 0.9975847 |
ENST00000544772 | ENST00000397872 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - | 0.002415247 | 0.9975847 |
ENST00000544772 | ENST00000397873 | CHEK2 | chr22 | 29085123 | - | THOC5 | chr22 | 29932727 | - | 0.002550976 | 0.997449 |
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Fusion Genomic Features for CHEK2-THOC5 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CHEK2-THOC5 |
Go to FGviewer for the breakpoints of chr22:29085123-chr22:29932727 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
CHEK2 | . |
FUNCTION: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000328354 | - | 14 | 15 | 113_175 | 514.0 | 544.0 | Domain | FHA |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000328354 | - | 14 | 15 | 220_486 | 514.0 | 544.0 | Domain | Protein kinase |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000348295 | - | 13 | 14 | 113_175 | 485.0 | 515.0 | Domain | FHA |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000348295 | - | 13 | 14 | 220_486 | 485.0 | 515.0 | Domain | Protein kinase |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382566 | - | 13 | 14 | 113_175 | 493.3333333333333 | 276.6666666666667 | Domain | FHA |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382566 | - | 13 | 14 | 220_486 | 493.3333333333333 | 276.6666666666667 | Domain | Protein kinase |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382578 | - | 12 | 13 | 113_175 | 423.0 | 453.0 | Domain | FHA |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382580 | - | 15 | 16 | 113_175 | 557.0 | 587.0 | Domain | FHA |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382580 | - | 15 | 16 | 220_486 | 557.0 | 587.0 | Domain | Protein kinase |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000402731 | - | 12 | 13 | 113_175 | 485.0 | 515.0 | Domain | FHA |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000402731 | - | 12 | 13 | 220_486 | 485.0 | 515.0 | Domain | Protein kinase |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000403642 | - | 11 | 12 | 113_175 | 423.0 | 453.0 | Domain | FHA |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000404276 | - | 13 | 14 | 113_175 | 514.0 | 544.0 | Domain | FHA |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000404276 | - | 13 | 14 | 220_486 | 514.0 | 544.0 | Domain | Protein kinase |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000405598 | - | 15 | 16 | 113_175 | 514.0 | 544.0 | Domain | FHA |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000405598 | - | 15 | 16 | 220_486 | 514.0 | 544.0 | Domain | Protein kinase |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000544772 | - | 15 | 16 | 113_175 | 293.0 | 323.0 | Domain | FHA |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000328354 | - | 14 | 15 | 227_234 | 514.0 | 544.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000328354 | - | 14 | 15 | 302_308 | 514.0 | 544.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000328354 | - | 14 | 15 | 351_352 | 514.0 | 544.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000348295 | - | 13 | 14 | 227_234 | 485.0 | 515.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000348295 | - | 13 | 14 | 302_308 | 485.0 | 515.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000348295 | - | 13 | 14 | 351_352 | 485.0 | 515.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382566 | - | 13 | 14 | 227_234 | 493.3333333333333 | 276.6666666666667 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382566 | - | 13 | 14 | 302_308 | 493.3333333333333 | 276.6666666666667 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382566 | - | 13 | 14 | 351_352 | 493.3333333333333 | 276.6666666666667 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382578 | - | 12 | 13 | 227_234 | 423.0 | 453.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382578 | - | 12 | 13 | 302_308 | 423.0 | 453.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382578 | - | 12 | 13 | 351_352 | 423.0 | 453.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382580 | - | 15 | 16 | 227_234 | 557.0 | 587.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382580 | - | 15 | 16 | 302_308 | 557.0 | 587.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382580 | - | 15 | 16 | 351_352 | 557.0 | 587.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000402731 | - | 12 | 13 | 227_234 | 485.0 | 515.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000402731 | - | 12 | 13 | 302_308 | 485.0 | 515.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000402731 | - | 12 | 13 | 351_352 | 485.0 | 515.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000403642 | - | 11 | 12 | 227_234 | 423.0 | 453.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000403642 | - | 11 | 12 | 302_308 | 423.0 | 453.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000403642 | - | 11 | 12 | 351_352 | 423.0 | 453.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000404276 | - | 13 | 14 | 227_234 | 514.0 | 544.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000404276 | - | 13 | 14 | 302_308 | 514.0 | 544.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000404276 | - | 13 | 14 | 351_352 | 514.0 | 544.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000405598 | - | 15 | 16 | 227_234 | 514.0 | 544.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000405598 | - | 15 | 16 | 302_308 | 514.0 | 544.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000405598 | - | 15 | 16 | 351_352 | 514.0 | 544.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000544772 | - | 15 | 16 | 227_234 | 293.0 | 323.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000328354 | - | 14 | 15 | 368_394 | 514.0 | 544.0 | Region | Note=T-loop/activation segment |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000348295 | - | 13 | 14 | 368_394 | 485.0 | 515.0 | Region | Note=T-loop/activation segment |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382566 | - | 13 | 14 | 368_394 | 493.3333333333333 | 276.6666666666667 | Region | Note=T-loop/activation segment |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382578 | - | 12 | 13 | 368_394 | 423.0 | 453.0 | Region | Note=T-loop/activation segment |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382580 | - | 15 | 16 | 368_394 | 557.0 | 587.0 | Region | Note=T-loop/activation segment |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000402731 | - | 12 | 13 | 368_394 | 485.0 | 515.0 | Region | Note=T-loop/activation segment |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000403642 | - | 11 | 12 | 368_394 | 423.0 | 453.0 | Region | Note=T-loop/activation segment |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000404276 | - | 13 | 14 | 368_394 | 514.0 | 544.0 | Region | Note=T-loop/activation segment |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000405598 | - | 15 | 16 | 368_394 | 514.0 | 544.0 | Region | Note=T-loop/activation segment |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000382578 | - | 12 | 13 | 220_486 | 423.0 | 453.0 | Domain | Protein kinase |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000403642 | - | 11 | 12 | 220_486 | 423.0 | 453.0 | Domain | Protein kinase |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000544772 | - | 15 | 16 | 220_486 | 293.0 | 323.0 | Domain | Protein kinase |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000544772 | - | 15 | 16 | 302_308 | 293.0 | 323.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000544772 | - | 15 | 16 | 351_352 | 293.0 | 323.0 | Nucleotide binding | Note=ATP |
Hgene | CHEK2 | chr22:29085123 | chr22:29932727 | ENST00000544772 | - | 15 | 16 | 368_394 | 293.0 | 323.0 | Region | Note=T-loop/activation segment |
Tgene | THOC5 | chr22:29085123 | chr22:29932727 | ENST00000397871 | 5 | 20 | 7_10 | 199.66666666666666 | 684.0 | Motif | Nuclear localization signal | |
Tgene | THOC5 | chr22:29085123 | chr22:29932727 | ENST00000397872 | 6 | 21 | 7_10 | 199.66666666666666 | 684.0 | Motif | Nuclear localization signal | |
Tgene | THOC5 | chr22:29085123 | chr22:29932727 | ENST00000397873 | 6 | 21 | 7_10 | 199.66666666666666 | 684.0 | Motif | Nuclear localization signal | |
Tgene | THOC5 | chr22:29085123 | chr22:29932727 | ENST00000490103 | 5 | 20 | 7_10 | 199.66666666666666 | 684.0 | Motif | Nuclear localization signal |
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Fusion Gene Sequence for CHEK2-THOC5 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000544772_ENST00000490103_TCGA-NF-A4WX-01A_CHEK2_chr22_29085123_-_THOC5_chr22_29932727_length(transcript)=6347nt_BP=2316nt CTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTA CCAGTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGG GCCCCATGGGCCGCCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAAC CCCTGTCGGCCAAAACCCCCACACCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCG TGGGGAAAAGCAAAGAGAGCGTCTAACCAGACTAATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGG TTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGGCATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCC GGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGGTTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTG TGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAG CCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGC CAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCT GAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAAT GACAACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGC AAGAAACACTTTCGGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTA AATACAGAGCTTGTAGGGAAAGGAAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGAGAAAATA CTTAAAATCTACTCTCTCAGCTGATTTTCAAAAATACGGCGGGGCGCGGTGGCTCACGTCTTTAATCCCAGCACTTTGGGAGGCCGAGGC TGGCAGATCACCTGAGTTTTTGTCTTTTTTGATCTGACTGTAGATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATG TCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAGGAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGC AAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAAATAGAAATTTTGAAAAAGCTAAATCAT CCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGGGAGAGCTGTTTGACAAA GTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGAAAACGGT ATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCC AAGATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCT GGGTATAACCGTGCTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACT CAAGTGTCACTGAAGGATCAGATCACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTT GTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCACGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAG AGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAGCTCTACCCCAGGTTCTAGCCCAGGCTGGCAGAGAAGTACCGAGAGTG CCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCA GGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCT CTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAA GGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCAC ACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAG TGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCC CATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAA TCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCCCTATTTGTGGGTGCAGAAGCTGGG TGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCACATGGAGACCACCATGAAACT TCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCATTGTGCCAGTTACCAGTGATTGCCA GTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTACATGGAGCTGCACTTCACCAAAGA CATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCGCTGTGGT GTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACAT TCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCG GCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTG TCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCA GACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACTCTTGATATTCTCCAAAGAC ACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTGGAAGGGCAGGTGGGAG CTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAAAGATTCCAATTCTGCAGAG AGATGCTCACCTCTTGTCTACGCACACCCTATTTGTGCTTTGCGGGGTGAGGTCCTCATGATCTTGTATTTATTATCCCAAGTTCCTGCT GTTAAGAGGTGGTAGGAGAAGCCAAAGGCAGCAGAGCACAAAAAGCAAAACTCTTCCCTCCCCACCCGCTCTTCCCATTAGTCCTGTCAG GGTTGCCGATGGACAAATTGTCTCTGATCGTTGGATGTTATAAATGTCTGACAGTGCAGTGCAAACAGAAGACAAACTCAGTTGATCCTT GAACAACTCAGGGGTTAGGGGCACCAACACCCCCTGCCCTGCACAGTTGAAAAATCCGTGTATAACTTTTGACTCCCTAAAAACTTAACT AATAGCCTGCTGTTGACCAGTAGTATGCTATTAGTAGTTACTTACTGCTAACATAGTCAGTACATATTTTCAGTATATATTTTGTATCTT ATACACTGTATTCTTACAATACAGTAAACTAGAGAAAAGAAAATGTTATAAGGAAAGTCACAAGGGGGCCTGAGTGCAGTGGCTCACGTC TGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCGACATGGTGAAACCCTGT CTCTACTAAAAACATGGAAATTAGCCAAGCGTGGTGGCGCATGCCTGTAGTCCCAGTTACTCAGGAGGCTGAGGCAGAATTACTTGAACC CATGAGGCAGAGGTTGCAGTAAGCCAAGATCACGCTCCTGCGCTCCGGCTTGGGCGAGAGTGAGACTCCGTCTCAAAAATAAATAAATAA GAAAGCCATAAGGAAGAAAATATATATCTACTATTAAGTAGAAGTGGATCACCATAAAGGTCTTCACATACTGTCTCAGGGTTGAATAGT CTAAGGAAGAGGAGGGGTTGGTCTTGGTGTCTCAGGGATGGCAGAGGCAGAAAAAGTGGGGGAGGTGGAGGGGGAGGCAGGCACCACTGT TATTTTTATTGAACAAAATCTGTGCAGGGACTCATGACTGTAATCCTAGTACTTTGGAAAGCTAAGGCGGGAGGATCCCTTGAGGCCAGG AGTTCAGGTCCAGCCTGGGCAACGTAGTGAGAGACCCTGTATCTACAAAAAATTTAAAAATCAGCCAGGTGTGGTGGTATGCACCAATAG TCCCAGTTACTCAGAAGGCTGAGGTGGGCGGATGACTGGAGTCCAGGAGTTCAAGGTAGCAGTGAGCTATTCATCGTGCCTGTACTGTAC TCCAGCCTGGGAAACAATGCGAGTCCCTATCTCTAAAAAATTTTAAAAAAAGAAATCTGCATATAATAGACCCACAGAGTCCAAACTATT GTTCAGAGATCAACTGTACTTCACAGAGAGTAATTCTAAGTCTTACAGGATTTCATGGAGATGGCGAGAGTGGTGTTGGAGAATCAATCA CATACAGAGATACAGGACAGTGAGACCAGGTAACATTTGAGGAGAATATTTTTTTTTTATTGAGACAGGGTCTTGCTCTGTTGTCCAGGC TGGAGTGCAGTGGCACGAACACAGCTCACTGCCGCCTCAACCTCTCCTGGGTTCAAGTGATCCTCCTGCCTCAGCCTCCCAAGTAGCTGG GACCACAGGTGTGTGCCACCATTTCTGGCTAATTTTTAAATTTTTTGTAGAGGCGGGATCCCACTATTTTTCCCAGGCTGGTCTCAAACT CCTGGGCTCAAATGATCCTCCCACCTCGGCCTCCCAAAGTGCTAGGATTATAGGCATGAGCCACCACACCCGGCCTGAGTAGAGTCTTTA AGGTAATGACAAAAGTGCCTCAAAATATAATTATTTGATTAAGAGAAGTCTTGGGAAGATAGGTAACAACCTTTAAAATGTTCATAAAAT TACATCCTTTGTAATACTCCTGCAAGTCAAAGTAAAGGATGGCATAGACTATTCTTGGACAGTTTTGTCAAAAAGTGTATCTTGACCCCA CCATCAGTACTCCATTCTTCATTTTAAAAAATAAGATGGGCTGGGCACAGTGGCTTACGCCTTTAATATCAGTACTTTGGGAGGCTGGTG GGCGGATCACCTGAGATCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCA TGGTGGTGCGCGCCTGTAATCCCAGCCACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCCCGAGGCGGAGGTTGCACTGAGCCGAG >In-frame_ENST00000544772_ENST00000490103_TCGA-NF-A4WX-01A_CHEK2_chr22_29085123_-_THOC5_chr22_29932727_length(amino acids)=483AA_start in transcript=2317_stop in transcript=3768 MAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAI EGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVT TAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSAS HMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIVDAGLAGDTNLYYMALIERGT AKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPK -------------------------------------------------------------- >In-frame_ENST00000544772_ENST00000397871_TCGA-NF-A4WX-01A_CHEK2_chr22_29085123_-_THOC5_chr22_29932727_length(transcript)=4058nt_BP=2316nt CTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTA CCAGTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGG GCCCCATGGGCCGCCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAAC CCCTGTCGGCCAAAACCCCCACACCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCG TGGGGAAAAGCAAAGAGAGCGTCTAACCAGACTAATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGG TTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGGCATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCC GGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGGTTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTG TGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAG CCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGC CAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCT GAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAAT GACAACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGC AAGAAACACTTTCGGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTA AATACAGAGCTTGTAGGGAAAGGAAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGAGAAAATA CTTAAAATCTACTCTCTCAGCTGATTTTCAAAAATACGGCGGGGCGCGGTGGCTCACGTCTTTAATCCCAGCACTTTGGGAGGCCGAGGC TGGCAGATCACCTGAGTTTTTGTCTTTTTTGATCTGACTGTAGATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATG TCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAGGAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGC AAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAAATAGAAATTTTGAAAAAGCTAAATCAT CCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGGGAGAGCTGTTTGACAAA GTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGAAAACGGT ATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCC AAGATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCT GGGTATAACCGTGCTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACT CAAGTGTCACTGAAGGATCAGATCACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTT GTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCACGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAG AGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAGCTCTACCCCAGGTTCTAGCCCAGGCTGGCAGAGAAGTACCGAGAGTG CCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCA GGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCT CTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAA GGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCAC ACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAG TGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCC CATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAA TCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCCCTATTTGTGGGTGCAGAAGCTGGG TGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCACATGGAGACCACCATGAAACT TCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCATTGTGCCAGTTACCAGTGATTGCCA GTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTACATGGAGCTGCACTTCACCAAAGA CATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCGCTGTGGT GTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACAT TCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCG GCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTG TCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCA GACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACTCTTGATATTCTCCAAAGAC ACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTGGAAGGGCAGGTGGGAG CTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAAAGATTCCAATTCTGCAGAG >In-frame_ENST00000544772_ENST00000397871_TCGA-NF-A4WX-01A_CHEK2_chr22_29085123_-_THOC5_chr22_29932727_length(amino acids)=483AA_start in transcript=2317_stop in transcript=3768 MAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAI EGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVT TAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSAS HMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIVDAGLAGDTNLYYMALIERGT AKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPK -------------------------------------------------------------- >In-frame_ENST00000544772_ENST00000397872_TCGA-NF-A4WX-01A_CHEK2_chr22_29085123_-_THOC5_chr22_29932727_length(transcript)=4058nt_BP=2316nt CTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTA CCAGTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGG GCCCCATGGGCCGCCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAAC CCCTGTCGGCCAAAACCCCCACACCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCG TGGGGAAAAGCAAAGAGAGCGTCTAACCAGACTAATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGG TTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGGCATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCC GGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGGTTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTG TGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAG CCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGC CAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCT GAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAAT GACAACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGC AAGAAACACTTTCGGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTA AATACAGAGCTTGTAGGGAAAGGAAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGAGAAAATA CTTAAAATCTACTCTCTCAGCTGATTTTCAAAAATACGGCGGGGCGCGGTGGCTCACGTCTTTAATCCCAGCACTTTGGGAGGCCGAGGC TGGCAGATCACCTGAGTTTTTGTCTTTTTTGATCTGACTGTAGATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATG TCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAGGAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGC AAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAAATAGAAATTTTGAAAAAGCTAAATCAT CCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGGGAGAGCTGTTTGACAAA GTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGAAAACGGT ATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCC AAGATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCT GGGTATAACCGTGCTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACT CAAGTGTCACTGAAGGATCAGATCACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTT GTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCACGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAG AGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAGCTCTACCCCAGGTTCTAGCCCAGGCTGGCAGAGAAGTACCGAGAGTG CCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCA GGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCT CTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAA GGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCAC ACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAG TGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCC CATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAA TCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCCCTATTTGTGGGTGCAGAAGCTGGG TGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCACATGGAGACCACCATGAAACT TCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCATTGTGCCAGTTACCAGTGATTGCCA GTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTACATGGAGCTGCACTTCACCAAAGA CATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCGCTGTGGT GTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACAT TCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCG GCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTG TCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCA GACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACTCTTGATATTCTCCAAAGAC ACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTGGAAGGGCAGGTGGGAG CTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAAAGATTCCAATTCTGCAGAG >In-frame_ENST00000544772_ENST00000397872_TCGA-NF-A4WX-01A_CHEK2_chr22_29085123_-_THOC5_chr22_29932727_length(amino acids)=483AA_start in transcript=2317_stop in transcript=3768 MAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAI EGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVT TAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSAS HMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIVDAGLAGDTNLYYMALIERGT AKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPK -------------------------------------------------------------- >In-frame_ENST00000544772_ENST00000397873_TCGA-NF-A4WX-01A_CHEK2_chr22_29085123_-_THOC5_chr22_29932727_length(transcript)=3868nt_BP=2316nt CTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTA CCAGTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGG GCCCCATGGGCCGCCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAAC CCCTGTCGGCCAAAACCCCCACACCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCG TGGGGAAAAGCAAAGAGAGCGTCTAACCAGACTAATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGG TTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGGCATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCC GGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGGTTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTG TGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAG CCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGC CAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCT GAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAAT GACAACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGC AAGAAACACTTTCGGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTA AATACAGAGCTTGTAGGGAAAGGAAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGAGAAAATA CTTAAAATCTACTCTCTCAGCTGATTTTCAAAAATACGGCGGGGCGCGGTGGCTCACGTCTTTAATCCCAGCACTTTGGGAGGCCGAGGC TGGCAGATCACCTGAGTTTTTGTCTTTTTTGATCTGACTGTAGATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATG TCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAGGAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGC AAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAAATAGAAATTTTGAAAAAGCTAAATCAT CCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGGGAGAGCTGTTTGACAAA GTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGAAAACGGT ATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCC AAGATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCT GGGTATAACCGTGCTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACT CAAGTGTCACTGAAGGATCAGATCACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTT GTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCACGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAG AGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAGCTCTACCCCAGGTTCTAGCCCAGGCTGGCAGAGAAGTACCGAGAGTG CCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCA GGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCT CTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAA GGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCAC ACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAG TGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCC CATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAA TCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCCCTATTTGTGGGTGCAGAAGCTGGG TGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCACATGGAGACCACCATGAAACT TCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCATTGTGCCAGTTACCAGTGATTGCCA GTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTACATGGAGCTGCACTTCACCAAAGA CATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCGCTGTGGT GTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACAT TCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCG GCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTG TCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCA >In-frame_ENST00000544772_ENST00000397873_TCGA-NF-A4WX-01A_CHEK2_chr22_29085123_-_THOC5_chr22_29932727_length(amino acids)=483AA_start in transcript=2317_stop in transcript=3768 MAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAI EGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVT TAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSAS HMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIVDAGLAGDTNLYYMALIERGT AKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CHEK2-THOC5 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Tgene | THOC5 | chr22:29085123 | chr22:29932727 | ENST00000397871 | 5 | 20 | 2_144 | 199.66666666666666 | 684.0 | CSF1R | |
Tgene | THOC5 | chr22:29085123 | chr22:29932727 | ENST00000397872 | 6 | 21 | 2_144 | 199.66666666666666 | 684.0 | CSF1R | |
Tgene | THOC5 | chr22:29085123 | chr22:29932727 | ENST00000397873 | 6 | 21 | 2_144 | 199.66666666666666 | 684.0 | CSF1R | |
Tgene | THOC5 | chr22:29085123 | chr22:29932727 | ENST00000490103 | 5 | 20 | 2_144 | 199.66666666666666 | 684.0 | CSF1R | |
Tgene | THOC5 | chr22:29085123 | chr22:29932727 | ENST00000397871 | 5 | 20 | 2_199 | 199.66666666666666 | 684.0 | THOC7 | |
Tgene | THOC5 | chr22:29085123 | chr22:29932727 | ENST00000397872 | 6 | 21 | 2_199 | 199.66666666666666 | 684.0 | THOC7 | |
Tgene | THOC5 | chr22:29085123 | chr22:29932727 | ENST00000397873 | 6 | 21 | 2_199 | 199.66666666666666 | 684.0 | THOC7 | |
Tgene | THOC5 | chr22:29085123 | chr22:29932727 | ENST00000490103 | 5 | 20 | 2_199 | 199.66666666666666 | 684.0 | THOC7 |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CHEK2-THOC5 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CHEK2 | O96017 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | CHEK2 | O96017 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | CHEK2 | O96017 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
Hgene | CHEK2 | O96017 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for CHEK2-THOC5 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CHEK2 | C0009405 | Hereditary Nonpolyposis Colorectal Neoplasms | 12 | CLINGEN |
Hgene | CHEK2 | C1112155 | Hereditary non-polyposis colorectal cancer syndrome | 12 | CLINGEN |
Hgene | CHEK2 | C1333990 | Hereditary Nonpolyposis Colorectal Cancer | 12 | CLINGEN |
Hgene | CHEK2 | C1333991 | Hereditary Non-Polyposis Colon Cancer Type 2 | 12 | CLINGEN |
Hgene | CHEK2 | C2936783 | Colorectal cancer, hereditary nonpolyposis, type 1 | 12 | CLINGEN |
Hgene | CHEK2 | C0346153 | Breast Cancer, Familial | 9 | CLINGEN |
Hgene | CHEK2 | C0006142 | Malignant neoplasm of breast | 7 | CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | CHEK2 | C0678222 | Breast Carcinoma | 4 | CGI;CTD_human |
Hgene | CHEK2 | C1257931 | Mammary Neoplasms, Human | 4 | CTD_human |
Hgene | CHEK2 | C1458155 | Mammary Neoplasms | 4 | CTD_human |
Hgene | CHEK2 | C4704874 | Mammary Carcinoma, Human | 4 | CTD_human |
Hgene | CHEK2 | C0085390 | Li-Fraumeni Syndrome | 3 | CTD_human;ORPHANET |
Hgene | CHEK2 | C1836482 | Li-Fraumeni Syndrome 2 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | CHEK2 | C0009402 | Colorectal Carcinoma | 1 | CTD_human;GENOMICS_ENGLAND |
Hgene | CHEK2 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | CHEK2 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | CHEK2 | C0024302 | Reticulosarcoma | 1 | CTD_human |
Hgene | CHEK2 | C0024304 | Lymphoma, Mixed-Cell | 1 | CTD_human |
Hgene | CHEK2 | C0024305 | Lymphoma, Non-Hodgkin | 1 | CTD_human |
Hgene | CHEK2 | C0024306 | Lymphoma, Undifferentiated | 1 | CTD_human |
Hgene | CHEK2 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
Hgene | CHEK2 | C0027819 | Neuroblastoma | 1 | CTD_human |
Hgene | CHEK2 | C0029463 | Osteosarcoma | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
Hgene | CHEK2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | CHEK2 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | CHEK2 | C0079740 | High Grade Lymphoma (neoplasm) | 1 | CTD_human |
Hgene | CHEK2 | C0079741 | Lymphoma, Intermediate-Grade | 1 | CTD_human |
Hgene | CHEK2 | C0079747 | Low Grade Lymphoma (neoplasm) | 1 | CTD_human |
Hgene | CHEK2 | C0079757 | Diffuse Mixed-Cell Lymphoma | 1 | CTD_human |
Hgene | CHEK2 | C0079770 | Lymphoma, Small Noncleaved-Cell | 1 | CTD_human |
Hgene | CHEK2 | C0206720 | Squamous Cell Neoplasms | 1 | CTD_human |
Hgene | CHEK2 | C0235874 | Disease Exacerbation | 1 | CTD_human |
Hgene | CHEK2 | C0238033 | Carcinoma of Male Breast | 1 | CTD_human |
Hgene | CHEK2 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
Hgene | CHEK2 | C0242788 | Breast Neoplasms, Male | 1 | CTD_human |
Hgene | CHEK2 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | CHEK2 | C0677776 | Hereditary Breast and Ovarian Cancer Syndrome | 1 | ORPHANET |
Hgene | CHEK2 | C0751688 | Malignant Squamous Cell Neoplasm | 1 | CTD_human |
Hgene | CHEK2 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
Hgene | CHEK2 | C2931456 | Prostate cancer, familial | 1 | CTD_human;ORPHANET |
Hgene | CHEK2 | C3714542 | Lymphoma, Diffuse | 1 | CTD_human |
Hgene | CHEK2 | C4721532 | Lymphoma, Non-Hodgkin, Familial | 1 | CTD_human |
Hgene | CHEK2 | C4722327 | PROSTATE CANCER, HEREDITARY, 1 | 1 | CTD_human |