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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHKA-GDPD5 (FusionGDB2 ID:16525)

Fusion Gene Summary for CHKA-GDPD5

check button Fusion gene summary
Fusion gene informationFusion gene name: CHKA-GDPD5
Fusion gene ID: 16525
HgeneTgene
Gene symbol

CHKA

GDPD5

Gene ID

1119

81544

Gene namecholine kinase alphaglycerophosphodiester phosphodiesterase domain containing 5
SynonymsCHK|CK|CKI|EKGDE2|PP1665
Cytomap

11q13.2

11q13.4-q13.5

Type of geneprotein-codingprotein-coding
Descriptioncholine kinase alphaCHETK-alphaethanolamine kinaseglycerophosphodiester phosphodiesterase domain-containing protein 5glycerophosphodiester phosphodiesterase 2
Modification date2020031320200313
UniProtAcc

P35790

Q8WTR4

Ensembl transtripts involved in fusion geneENST00000265689, ENST00000533728, 
ENST00000356135, 		ENST00000336898, 
ENST00000376282, ENST00000529095, 
ENST00000526177, ENST00000533784, 
ENST00000529721, ENST00000533805, 
ENST00000443276, 
Fusion gene scores* DoF score12 X 7 X 5=4209 X 7 X 7=441
# samples 1314
** MAII scorelog2(13/420*10)=-1.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/441*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHKA [Title/Abstract] AND GDPD5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHKA(67842184)-GDPD5(75173934), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHKA

GO:0006646

phosphatidylethanolamine biosynthetic process

19915674

HgeneCHKA

GO:0006656

phosphatidylcholine biosynthetic process

19915674


check buttonFusion gene breakpoints across CHKA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GDPD5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-5425-01ACHKAchr11

67842184

-GDPD5chr11

75173934

-


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Fusion Gene ORF analysis for CHKA-GDPD5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265689ENST00000336898CHKAchr11

67842184

-GDPD5chr11

75173934

-
5CDS-intronENST00000265689ENST00000376282CHKAchr11

67842184

-GDPD5chr11

75173934

-
5CDS-intronENST00000265689ENST00000529095CHKAchr11

67842184

-GDPD5chr11

75173934

-
5CDS-intronENST00000265689ENST00000526177CHKAchr11

67842184

-GDPD5chr11

75173934

-
5CDS-intronENST00000265689ENST00000533784CHKAchr11

67842184

-GDPD5chr11

75173934

-
5CDS-intronENST00000265689ENST00000529721CHKAchr11

67842184

-GDPD5chr11

75173934

-
5CDS-intronENST00000265689ENST00000533805CHKAchr11

67842184

-GDPD5chr11

75173934

-
5CDS-intronENST00000265689ENST00000443276CHKAchr11

67842184

-GDPD5chr11

75173934

-
intron-3CDSENST00000533728ENST00000336898CHKAchr11

67842184

-GDPD5chr11

75173934

-
intron-intronENST00000533728ENST00000376282CHKAchr11

67842184

-GDPD5chr11

75173934

-
intron-intronENST00000533728ENST00000529095CHKAchr11

67842184

-GDPD5chr11

75173934

-
intron-intronENST00000533728ENST00000526177CHKAchr11

67842184

-GDPD5chr11

75173934

-
intron-intronENST00000533728ENST00000533784CHKAchr11

67842184

-GDPD5chr11

75173934

-
intron-intronENST00000533728ENST00000529721CHKAchr11

67842184

-GDPD5chr11

75173934

-
intron-intronENST00000533728ENST00000533805CHKAchr11

67842184

-GDPD5chr11

75173934

-
intron-intronENST00000533728ENST00000443276CHKAchr11

67842184

-GDPD5chr11

75173934

-
In-frameENST00000356135ENST00000336898CHKAchr11

67842184

-GDPD5chr11

75173934

-
5CDS-intronENST00000356135ENST00000376282CHKAchr11

67842184

-GDPD5chr11

75173934

-
5CDS-intronENST00000356135ENST00000529095CHKAchr11

67842184

-GDPD5chr11

75173934

-
5CDS-intronENST00000356135ENST00000526177CHKAchr11

67842184

-GDPD5chr11

75173934

-
5CDS-intronENST00000356135ENST00000533784CHKAchr11

67842184

-GDPD5chr11

75173934

-
5CDS-intronENST00000356135ENST00000529721CHKAchr11

67842184

-GDPD5chr11

75173934

-
5CDS-intronENST00000356135ENST00000533805CHKAchr11

67842184

-GDPD5chr11

75173934

-
5CDS-intronENST00000356135ENST00000443276CHKAchr11

67842184

-GDPD5chr11

75173934

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265689CHKAchr1167842184-ENST00000336898GDPD5chr1175173934-3225657182357779
ENST00000356135CHKAchr1167842184-ENST00000336898GDPD5chr1175173934-34118432102543777

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265689ENST00000336898CHKAchr1167842184-GDPD5chr1175173934-0.0329453760.9670546
ENST00000356135ENST00000336898CHKAchr1167842184-GDPD5chr1175173934-0.0392651930.96073484

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Fusion Genomic Features for CHKA-GDPD5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHKA-GDPD5


check button Go to

FGviewer for the breakpoints of chr11:67842184-chr11:75173934

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHKA

P35790

GDPD5

Q8WTR4

FUNCTION: Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. {ECO:0000269|PubMed:19915674}.FUNCTION: Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (By similarity). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (By similarity). {ECO:0000250|UniProtKB:Q3KTM2, ECO:0000250|UniProtKB:Q640M6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHKAchr11:67842184chr11:75173934ENST00000265689-41250_85210.0458.0Compositional biasNote=Pro-rich
HgeneCHKAchr11:67842184chr11:75173934ENST00000356135-31150_85192.0440.0Compositional biasNote=Pro-rich
HgeneCHKAchr11:67842184chr11:75173934ENST00000265689-412117_123210.0458.0Nucleotide bindingNote=ATP
HgeneCHKAchr11:67842184chr11:75173934ENST00000265689-412207_213210.0458.0Nucleotide bindingNote=ATP
HgeneCHKAchr11:67842184chr11:75173934ENST00000356135-311117_123192.0440.0Nucleotide bindingNote=ATP
HgeneCHKAchr11:67842184chr11:75173934ENST00000265689-412119_121210.0458.0RegionNote=Substrate binding
HgeneCHKAchr11:67842184chr11:75173934ENST00000356135-311119_121192.0440.0RegionNote=Substrate binding
TgeneGDPD5chr11:67842184chr11:75173934ENST00000336898217228_48539.0606.0DomainNote=GP-PDE
TgeneGDPD5chr11:67842184chr11:75173934ENST00000376282013228_4850487.0DomainNote=GP-PDE
TgeneGDPD5chr11:67842184chr11:75173934ENST00000526177013228_4850468.0DomainNote=GP-PDE
TgeneGDPD5chr11:67842184chr11:75173934ENST00000529721318228_48539.0606.0DomainNote=GP-PDE
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533784012228_4850487.0DomainNote=GP-PDE
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533805012228_4850361.0DomainNote=GP-PDE
TgeneGDPD5chr11:67842184chr11:75173934ENST00000336898217111_12539.0606.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST00000336898217147_16039.0606.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000336898217182_19239.0606.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST00000336898217214_49639.0606.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000336898217518_60539.0606.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST0000033689821764_8939.0606.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000376282013111_1250487.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST00000376282013147_1600487.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000376282013182_1920487.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST000003762820131_420487.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST00000376282013214_4960487.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000376282013518_6050487.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST0000037628201364_890487.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000526177013111_1250468.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST00000526177013147_1600468.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000526177013182_1920468.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST000005261770131_420468.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST00000526177013214_4960468.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000526177013518_6050468.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST0000052617701364_890468.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000529721318111_12539.0606.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST00000529721318147_16039.0606.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000529721318182_19239.0606.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST00000529721318214_49639.0606.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000529721318518_60539.0606.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST0000052972131864_8939.0606.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533784012111_1250487.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533784012147_1600487.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533784012182_1920487.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST000005337840121_420487.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533784012214_4960487.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533784012518_6050487.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST0000053378401264_890487.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533805012111_1250361.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533805012147_1600361.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533805012182_1920361.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST000005338050121_420361.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533805012214_4960361.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533805012518_6050361.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST0000053380501264_890361.0Topological domainExtracellular
TgeneGDPD5chr11:67842184chr11:75173934ENST00000336898217126_14639.0606.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000336898217161_18139.0606.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000336898217193_21339.0606.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST0000033689821743_6339.0606.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000336898217497_51739.0606.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST0000033689821790_11039.0606.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000376282013126_1460487.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000376282013161_1810487.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000376282013193_2130487.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST0000037628201343_630487.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000376282013497_5170487.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST0000037628201390_1100487.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000526177013126_1460468.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000526177013161_1810468.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000526177013193_2130468.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST0000052617701343_630468.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000526177013497_5170468.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST0000052617701390_1100468.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000529721318126_14639.0606.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000529721318161_18139.0606.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000529721318193_21339.0606.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST0000052972131843_6339.0606.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000529721318497_51739.0606.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST0000052972131890_11039.0606.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533784012126_1460487.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533784012161_1810487.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533784012193_2130487.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST0000053378401243_630487.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533784012497_5170487.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST0000053378401290_1100487.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533805012126_1460361.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533805012161_1810361.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533805012193_2130361.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST0000053380501243_630361.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST00000533805012497_5170361.0TransmembraneHelical
TgeneGDPD5chr11:67842184chr11:75173934ENST0000053380501290_1100361.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHKAchr11:67842184chr11:75173934ENST00000356135-311207_213192.0440.0Nucleotide bindingNote=ATP
TgeneGDPD5chr11:67842184chr11:75173934ENST000003368982171_4239.0606.0Topological domainCytoplasmic
TgeneGDPD5chr11:67842184chr11:75173934ENST000005297213181_4239.0606.0Topological domainCytoplasmic


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Fusion Gene Sequence for CHKA-GDPD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000265689_ENST00000336898_TCGA-05-5425-01A_CHKA_chr11_67842184_-_GDPD5_chr11_75173934_length(transcript)=3225nt_BP=657nt
CCGCGCCTCCTCGGCCGCCTGTCGGGCATGAAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTGAGC
TGCGGTAGCGGCAGCGCGGCCCCGGCGCCCGGCGTGGGGCAGCAGCGCGACGCCGCCAGCGACCTCGAGTCCAAGCAGCTGGGCGGCCAA
CAGCCGCCGCTCGCGCTGCCCCCTCCGCCGCCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAG
CAGCCGGAGCCCCGGACGCGGCGCAGGGCCTATCTGTGGTGCAAGGAGTTCCTGCCCGGCGCCTGGCGGGGCCTCCGCGAGGACGAGTTC
CACATCAGTGTCATCAGAGGCGGCCTTAGCAACATGCTGTTCCAGTGCTCCCTACCTGACACCACAGCCACCCTTGGTGATGAGCCTCGG
AAAGTGCTCCTGCGGCTGTATGGAGCGATTTTGCAGATGAGGTCCTGTAATAAAGAGGGATCCGAACAAGCTCAGAAAGAAAATGAATTT
CAAGGGGCTGAGGCCATGGTTCTGGAGAGCGTTATGTTTGCCATTCTCGCAGAGAGGTCACTTGGGCCAAAACTCTATGGCATCTTTCCC
CAAGGCCGACTGGAGCAGTTCATCCCGTGGGAGCGCCTCTGGTTCCTGCTCCTCACCTTCACCTTTGGCCTCACGCTCACCTGGCTTTAC
TTCTGGTGGGAAGTCCACAATGACTATGATGAATTCAACTGGTACCTCTACAACCGCATGGGCTACTGGAGCGACTGGCCCGTACCCATC
CTTGTGACCACAGCTGCTGCCTTCGCATACATCGCTGGCCTCCTGGTCCTGGCACTATGTCACATTGCCGTGGGGCAGCAGATGAACCTG
CACTGGCTGCACAAGATCGGGCTGGTGGTCATCCTGGCTTCCACGGTGGTGGCCATGTCGGCCGTGGCCCAGCTGTGGGAGGACGAGTGG
GAGGTGCTGCTGATCTCCCTGCAGGGCACAGCGCCATTCCTGCATGTGGGGGCTGTGGCAGCAGTCACCATGCTCTCCTGGATCGTGGCA
GGACAGTTCGCCCGCGCAGAGCGGACCTCCTCCCAGGTGACCATTCTCTGTACCTTCTTCACCGTGGTGTTTGCCCTCTACCTGGCCCCT
CTCACCATCTCCTCTCCCTGCATCATGGAGAAGAAAGACCTCGGCCCCAAGCCTGCTCTCATTGGCCACCGCGGGGCCCCCATGCTGGCT
CCAGAGCACACGCTCATGTCCTTCCGGAAGGCCCTCGAGCAGAAGCTGTACGGGCTCCAGGCTGACATTACCATCAGCCTGGACGGCGTG
CCCTTCCTCATGCATGACACCACCCTGCGGCGCACCACCAACGTGGAGGAGGAGTTCCCGGAGCTGGCCCGCAGGCCTGCCTCCATGCTT
AACTGGACCACCCTGCAGAGACTCAACGCTGGCCAGTGGTTCCTGAAGACTGACCCCTTCTGGACAGCCAGCTCCCTGTCACCCTCCGAC
CACAGAGAGGCCCAGAACCAGTCCATCTGCAGCCTGGCAGAGCTCCTGGAGCTGGCCAAGGGCAATGCCACACTGCTGCTCAACCTGCGT
GACCCGCCCCGGGAGCACCCCTACCGCAGCAGTTTTATCAACGTGACTCTGGAGGCCGTGCTGCACTCCGGCTTCCCCCAGCACCAGGTC
ATGTGGCTGCCTAGCAGGCAGAGGCCCCTGGTGCGGAAGGTGGCTCCCGGCTTCCAACAGACATCAGGCTCCAAGGAGGCAGTCGCCAGC
CTGCGGAGAGGCCACATCCAGCGGCTGAACCTGCGCTACACTCAGGTGTCCCGCCAGGAGCTCAGGGACTACGCGTCCTGGAACCTGAGT
GTGAACCTCTACACAGTCAACGCACCGTGGCTCTTCTCCCTGCTGTGGTGTGCGGGGGTCCCATCCGTCACCTCTGACAACTCCCACGCC
CTGTCCCAGGTGCCTTCCCCCCTCTGGATCATGCCCCCGGACGAGTACTGTCTCATGTGGGTCACTGCCGACCTGGTCTCCTTCACCCTC
ATCGTGGGCATCTTCGTGCTCCAGAAGTGGCGCCTGGGTGGCATACGGAGCTACAACCCTGAGCAGATCATGCTGAGTGCTGCGGTGCGC
CGGACCAGCCGGGACGTCAGCATCATGAAGGAGAAGCTTATTTTCTCAGAGATCAGCGATGGTGTAGAGGTCTCCGATGTGCTCTCCGTA
TGTTCAGACAACAGTTATGACACATATGCCAACAGCACCGCCACCCCTGTGGGCCCCCGAGGGGGTGGCAGCCACACCAAGACCCTCATA
GAGCGGAGTGGGCGTTAGCTGAAGACATGTCTGTCCCACCTGTACCTGACACAGAAGCTGGGGAGCCTAGGAGAGCTGGTGGAAGTGTGT
CTGAACTCGGAGTGCTCTGGGAGCGGGCTCCACAGCCTCCTTGTGGGCTCCAGCCCCTTGTCAGCCGCAGCCTCTCTTGAGGGGGACTCC
CTGTCTCCTGAGGCCCAGCTGGGCCAGGACTCCATCCTTTCAGATGCCCCTGCAGGCCTGGGGCTCCTTCTGGGAAGTATGGGGCCTAGG
GCTTGGTCCCCCTCTTCTGAGGCCCTCTCCTGTATCCCGACCTGGAAGCTTTGATGGGTCATGGGCCATGCCATACCCCCTGTGGCAATG
GAGTGTGTGGATGCTCACCTGTGCCATCTGTCCTCCTGTCTGTGCCAGGAGGCACCTGAGTTCTCTGCTGTTATCCTGCCCCAAGGGCCT
GGGCCGAGCCTCTACCTGAAGCAACTCTGCTCTTCCTGTCAGTCTCAAAGCACAAGGAGGTTCAGCCCAGGAGGAAGCCAGCTGCAATGT
GGAGACACGTCCTCCTCCCCAACCCACCTCATGCCACCGCCAACCCCCTGCCCCAGGAGCGGGCCTGAGCCACGTCCTCTAGGAGCAGCT
GGAGATGGCCAAAAGAGTGAGCTCAGGACTACTGGATCCCATGCCCAGGTGTCCAGCAGACCTCAAGGCAGAAGGGTCACCTAACCCAGG
AGTCCACAGACTGATGTGACCTCAGGTTCCCACATCAGTGGCCACAGGGCAGGGCCCACCTGGTAGAAGTGTTCTGGATATGGCCAGGGT

>In-frame_ENST00000265689_ENST00000336898_TCGA-05-5425-01A_CHKA_chr11_67842184_-_GDPD5_chr11_75173934_length(amino acids)=779AA_start in transcript=18_stop in transcript=2357
MSGMKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRT
RRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAM
VLESVMFAILAERSLGPKLYGIFPQGRLEQFIPWERLWFLLLTFTFGLTLTWLYFWWEVHNDYDEFNWYLYNRMGYWSDWPVPILVTTAA
AFAYIAGLLVLALCHIAVGQQMNLHWLHKIGLVVILASTVVAMSAVAQLWEDEWEVLLISLQGTAPFLHVGAVAAVTMLSWIVAGQFARA
ERTSSQVTILCTFFTVVFALYLAPLTISSPCIMEKKDLGPKPALIGHRGAPMLAPEHTLMSFRKALEQKLYGLQADITISLDGVPFLMHD
TTLRRTTNVEEEFPELARRPASMLNWTTLQRLNAGQWFLKTDPFWTASSLSPSDHREAQNQSICSLAELLELAKGNATLLLNLRDPPREH
PYRSSFINVTLEAVLHSGFPQHQVMWLPSRQRPLVRKVAPGFQQTSGSKEAVASLRRGHIQRLNLRYTQVSRQELRDYASWNLSVNLYTV
NAPWLFSLLWCAGVPSVTSDNSHALSQVPSPLWIMPPDEYCLMWVTADLVSFTLIVGIFVLQKWRLGGIRSYNPEQIMLSAAVRRTSRDV

--------------------------------------------------------------
>In-frame_ENST00000356135_ENST00000336898_TCGA-05-5425-01A_CHKA_chr11_67842184_-_GDPD5_chr11_75173934_length(transcript)=3411nt_BP=843nt
GTGGCGAGCGCGAGGGCGGGCTGTGACGCGGCCGGCGCTCCTCGTGCGGCGGCGGCAGAGGAGCGAGTGCAGCGGCCAGCAGCACATCCC
CGCTCCACAGTCGCCGCAGTCGCCGCAGCCGCCGCCGCCGCCCCGCGCGCCCAACCGCCGCGGCCCCCTGCCCCGCCGGCCTGCCAGTGA
GAGAGCGGCGAGGGGGCGCCCGGCCGGACTCTGAGCCTAGTCCTCTCGCGCTGCGGCCGCCCGCGCCTCCTCGGCCGCCTGTCGGGCATG
AAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTGAGCTGCGGTAGCGGCAGCGCGGCCCCGGCGCCC
GGCGTGGGGCAGCAGCGCGACGCCGCCAGCGACCTCGAGTCCAAGCAGCTGGGCGGCCAACAGCCGCCGCTCGCGCTGCCCCCTCCGCCG
CCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAGCAGCCGGAGCCCCGGACGCGGCGCAGGGCC
TATCTGTGGTGCAAGGAGTTCCTGCCCGGCGCCTGGCGGGGCCTCCGCGAGGACGAGTTCCACATCAGTGTCATCAGAGGCGGCCTTAGC
AACATGCTGTTCCAGTGCTCCCTACCTGACACCACAGCCACCCTTGGTGATGAGCCTCGGAAAGTGCTCCTGCGGCTGTATGGAGCGATT
TTGCAGATGGGGGCTGAGGCCATGGTTCTGGAGAGCGTTATGTTTGCCATTCTCGCAGAGAGGTCACTTGGGCCAAAACTCTATGGCATC
TTTCCCCAAGGCCGACTGGAGCAGTTCATCCCGTGGGAGCGCCTCTGGTTCCTGCTCCTCACCTTCACCTTTGGCCTCACGCTCACCTGG
CTTTACTTCTGGTGGGAAGTCCACAATGACTATGATGAATTCAACTGGTACCTCTACAACCGCATGGGCTACTGGAGCGACTGGCCCGTA
CCCATCCTTGTGACCACAGCTGCTGCCTTCGCATACATCGCTGGCCTCCTGGTCCTGGCACTATGTCACATTGCCGTGGGGCAGCAGATG
AACCTGCACTGGCTGCACAAGATCGGGCTGGTGGTCATCCTGGCTTCCACGGTGGTGGCCATGTCGGCCGTGGCCCAGCTGTGGGAGGAC
GAGTGGGAGGTGCTGCTGATCTCCCTGCAGGGCACAGCGCCATTCCTGCATGTGGGGGCTGTGGCAGCAGTCACCATGCTCTCCTGGATC
GTGGCAGGACAGTTCGCCCGCGCAGAGCGGACCTCCTCCCAGGTGACCATTCTCTGTACCTTCTTCACCGTGGTGTTTGCCCTCTACCTG
GCCCCTCTCACCATCTCCTCTCCCTGCATCATGGAGAAGAAAGACCTCGGCCCCAAGCCTGCTCTCATTGGCCACCGCGGGGCCCCCATG
CTGGCTCCAGAGCACACGCTCATGTCCTTCCGGAAGGCCCTCGAGCAGAAGCTGTACGGGCTCCAGGCTGACATTACCATCAGCCTGGAC
GGCGTGCCCTTCCTCATGCATGACACCACCCTGCGGCGCACCACCAACGTGGAGGAGGAGTTCCCGGAGCTGGCCCGCAGGCCTGCCTCC
ATGCTTAACTGGACCACCCTGCAGAGACTCAACGCTGGCCAGTGGTTCCTGAAGACTGACCCCTTCTGGACAGCCAGCTCCCTGTCACCC
TCCGACCACAGAGAGGCCCAGAACCAGTCCATCTGCAGCCTGGCAGAGCTCCTGGAGCTGGCCAAGGGCAATGCCACACTGCTGCTCAAC
CTGCGTGACCCGCCCCGGGAGCACCCCTACCGCAGCAGTTTTATCAACGTGACTCTGGAGGCCGTGCTGCACTCCGGCTTCCCCCAGCAC
CAGGTCATGTGGCTGCCTAGCAGGCAGAGGCCCCTGGTGCGGAAGGTGGCTCCCGGCTTCCAACAGACATCAGGCTCCAAGGAGGCAGTC
GCCAGCCTGCGGAGAGGCCACATCCAGCGGCTGAACCTGCGCTACACTCAGGTGTCCCGCCAGGAGCTCAGGGACTACGCGTCCTGGAAC
CTGAGTGTGAACCTCTACACAGTCAACGCACCGTGGCTCTTCTCCCTGCTGTGGTGTGCGGGGGTCCCATCCGTCACCTCTGACAACTCC
CACGCCCTGTCCCAGGTGCCTTCCCCCCTCTGGATCATGCCCCCGGACGAGTACTGTCTCATGTGGGTCACTGCCGACCTGGTCTCCTTC
ACCCTCATCGTGGGCATCTTCGTGCTCCAGAAGTGGCGCCTGGGTGGCATACGGAGCTACAACCCTGAGCAGATCATGCTGAGTGCTGCG
GTGCGCCGGACCAGCCGGGACGTCAGCATCATGAAGGAGAAGCTTATTTTCTCAGAGATCAGCGATGGTGTAGAGGTCTCCGATGTGCTC
TCCGTATGTTCAGACAACAGTTATGACACATATGCCAACAGCACCGCCACCCCTGTGGGCCCCCGAGGGGGTGGCAGCCACACCAAGACC
CTCATAGAGCGGAGTGGGCGTTAGCTGAAGACATGTCTGTCCCACCTGTACCTGACACAGAAGCTGGGGAGCCTAGGAGAGCTGGTGGAA
GTGTGTCTGAACTCGGAGTGCTCTGGGAGCGGGCTCCACAGCCTCCTTGTGGGCTCCAGCCCCTTGTCAGCCGCAGCCTCTCTTGAGGGG
GACTCCCTGTCTCCTGAGGCCCAGCTGGGCCAGGACTCCATCCTTTCAGATGCCCCTGCAGGCCTGGGGCTCCTTCTGGGAAGTATGGGG
CCTAGGGCTTGGTCCCCCTCTTCTGAGGCCCTCTCCTGTATCCCGACCTGGAAGCTTTGATGGGTCATGGGCCATGCCATACCCCCTGTG
GCAATGGAGTGTGTGGATGCTCACCTGTGCCATCTGTCCTCCTGTCTGTGCCAGGAGGCACCTGAGTTCTCTGCTGTTATCCTGCCCCAA
GGGCCTGGGCCGAGCCTCTACCTGAAGCAACTCTGCTCTTCCTGTCAGTCTCAAAGCACAAGGAGGTTCAGCCCAGGAGGAAGCCAGCTG
CAATGTGGAGACACGTCCTCCTCCCCAACCCACCTCATGCCACCGCCAACCCCCTGCCCCAGGAGCGGGCCTGAGCCACGTCCTCTAGGA
GCAGCTGGAGATGGCCAAAAGAGTGAGCTCAGGACTACTGGATCCCATGCCCAGGTGTCCAGCAGACCTCAAGGCAGAAGGGTCACCTAA
CCCAGGAGTCCACAGACTGATGTGACCTCAGGTTCCCACATCAGTGGCCACAGGGCAGGGCCCACCTGGTAGAAGTGTTCTGGATATGGC

>In-frame_ENST00000356135_ENST00000336898_TCGA-05-5425-01A_CHKA_chr11_67842184_-_GDPD5_chr11_75173934_length(amino acids)=777AA_start in transcript=210_stop in transcript=2543
MSLVLSRCGRPRLLGRLSGMKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQ
PPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMGAEAMVL
ESVMFAILAERSLGPKLYGIFPQGRLEQFIPWERLWFLLLTFTFGLTLTWLYFWWEVHNDYDEFNWYLYNRMGYWSDWPVPILVTTAAAF
AYIAGLLVLALCHIAVGQQMNLHWLHKIGLVVILASTVVAMSAVAQLWEDEWEVLLISLQGTAPFLHVGAVAAVTMLSWIVAGQFARAER
TSSQVTILCTFFTVVFALYLAPLTISSPCIMEKKDLGPKPALIGHRGAPMLAPEHTLMSFRKALEQKLYGLQADITISLDGVPFLMHDTT
LRRTTNVEEEFPELARRPASMLNWTTLQRLNAGQWFLKTDPFWTASSLSPSDHREAQNQSICSLAELLELAKGNATLLLNLRDPPREHPY
RSSFINVTLEAVLHSGFPQHQVMWLPSRQRPLVRKVAPGFQQTSGSKEAVASLRRGHIQRLNLRYTQVSRQELRDYASWNLSVNLYTVNA
PWLFSLLWCAGVPSVTSDNSHALSQVPSPLWIMPPDEYCLMWVTADLVSFTLIVGIFVLQKWRLGGIRSYNPEQIMLSAAVRRTSRDVSI

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Fusion Gene PPI Analysis for CHKA-GDPD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHKA-GDPD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHKA-GDPD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHKAC0038219Status Dysraphicus1CTD_human
HgeneCHKAC0080178Spina Bifida1CTD_human
HgeneCHKAC0266508Rachischisis1CTD_human