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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHKA-SLC5A12 (FusionGDB2 ID:16534)

Fusion Gene Summary for CHKA-SLC5A12

check button Fusion gene summary
Fusion gene informationFusion gene name: CHKA-SLC5A12
Fusion gene ID: 16534
HgeneTgene
Gene symbol

CHKA

SLC5A12

Gene ID

1119

159963

Gene namecholine kinase alphasolute carrier family 5 member 12
SynonymsCHK|CK|CKI|EKSMCT2
Cytomap

11q13.2

11p14.2

Type of geneprotein-codingprotein-coding
Descriptioncholine kinase alphaCHETK-alphaethanolamine kinasesodium-coupled monocarboxylate transporter 2electroneutral sodium monocarboxylate cotransporterlow-affinity sodium-lactate cotransportersodium-iodide related cotransportersolute carrier family 5 (sodium/glucose cotransporter), member 12solute carrier
Modification date2020031320200313
UniProtAcc

P35790

.
Ensembl transtripts involved in fusion geneENST00000265689, ENST00000533728, 
ENST00000356135, 		ENST00000396005, 
ENST00000280467, 
Fusion gene scores* DoF score12 X 7 X 5=4202 X 1 X 1=2
# samples 132
** MAII scorelog2(13/420*10)=-1.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context

PubMed: CHKA [Title/Abstract] AND SLC5A12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHKA(67864486)-SLC5A12(26734253), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHKA

GO:0006646

phosphatidylethanolamine biosynthetic process

19915674

HgeneCHKA

GO:0006656

phosphatidylcholine biosynthetic process

19915674


check buttonFusion gene breakpoints across CHKA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC5A12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A1HK-01ACHKAchr11

67864486

-SLC5A12chr11

26734253

-


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Fusion Gene ORF analysis for CHKA-SLC5A12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265689ENST00000396005CHKAchr11

67864486

-SLC5A12chr11

26734253

-
In-frameENST00000265689ENST00000280467CHKAchr11

67864486

-SLC5A12chr11

26734253

-
intron-3CDSENST00000533728ENST00000396005CHKAchr11

67864486

-SLC5A12chr11

26734253

-
intron-3CDSENST00000533728ENST00000280467CHKAchr11

67864486

-SLC5A12chr11

26734253

-
In-frameENST00000356135ENST00000396005CHKAchr11

67864486

-SLC5A12chr11

26734253

-
In-frameENST00000356135ENST00000280467CHKAchr11

67864486

-SLC5A12chr11

26734253

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265689CHKAchr1167864486-ENST00000396005SLC5A12chr1126734253-6090489182006662
ENST00000265689CHKAchr1167864486-ENST00000280467SLC5A12chr1126734253-2134489181340440
ENST00000356135CHKAchr1167864486-ENST00000396005SLC5A12chr1126734253-63307292102246678
ENST00000356135CHKAchr1167864486-ENST00000280467SLC5A12chr1126734253-23747292101580456

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265689ENST00000396005CHKAchr1167864486-SLC5A12chr1126734253-0.0037444460.9962555
ENST00000265689ENST00000280467CHKAchr1167864486-SLC5A12chr1126734253-0.0246291890.97537076
ENST00000356135ENST00000396005CHKAchr1167864486-SLC5A12chr1126734253-0.0039944520.9960056
ENST00000356135ENST00000280467CHKAchr1167864486-SLC5A12chr1126734253-0.0370963440.9629037

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Fusion Genomic Features for CHKA-SLC5A12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHKA-SLC5A12


check button Go to

FGviewer for the breakpoints of chr11:67864486-chr11:26734253

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHKA

P35790

.
FUNCTION: Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. {ECO:0000269|PubMed:19915674}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHKAchr11:67864486chr11:26734253ENST00000265689-21250_85154.0458.0Compositional biasNote=Pro-rich
HgeneCHKAchr11:67864486chr11:26734253ENST00000356135-21150_85154.0440.0Compositional biasNote=Pro-rich
HgeneCHKAchr11:67864486chr11:26734253ENST00000265689-212117_123154.0458.0Nucleotide bindingNote=ATP
HgeneCHKAchr11:67864486chr11:26734253ENST00000356135-211117_123154.0440.0Nucleotide bindingNote=ATP
HgeneCHKAchr11:67864486chr11:26734253ENST00000265689-212119_121154.0458.0RegionNote=Substrate binding
HgeneCHKAchr11:67864486chr11:26734253ENST00000356135-211119_121154.0440.0RegionNote=Substrate binding
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709150_157113.0397.0Topological domainExtracellular
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709179_180113.0397.0Topological domainCytoplasmic
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709202_235113.0397.0Topological domainExtracellular
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709257_275113.0397.0Topological domainCytoplasmic
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709297_321113.0397.0Topological domainExtracellular
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709343_385113.0397.0Topological domainCytoplasmic
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709407_411113.0397.0Topological domainExtracellular
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709433_437113.0397.0Topological domainCytoplasmic
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709459_504113.0397.0Topological domainExtracellular
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709526_618113.0397.0Topological domainCytoplasmic
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015150_157113.0619.0Topological domainExtracellular
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015179_180113.0619.0Topological domainCytoplasmic
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015202_235113.0619.0Topological domainExtracellular
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015257_275113.0619.0Topological domainCytoplasmic
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015297_321113.0619.0Topological domainExtracellular
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015343_385113.0619.0Topological domainCytoplasmic
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015407_411113.0619.0Topological domainExtracellular
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015433_437113.0619.0Topological domainCytoplasmic
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015459_504113.0619.0Topological domainExtracellular
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015526_618113.0619.0Topological domainCytoplasmic
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709129_149113.0397.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709158_178113.0397.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709181_201113.0397.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709236_256113.0397.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709276_296113.0397.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709322_342113.0397.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709386_406113.0397.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709412_432113.0397.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709438_458113.0397.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709505_525113.0397.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015129_149113.0619.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015158_178113.0619.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015181_201113.0619.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015236_256113.0619.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015276_296113.0619.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015322_342113.0619.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015386_406113.0619.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015412_432113.0619.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015438_458113.0619.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015505_525113.0619.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHKAchr11:67864486chr11:26734253ENST00000265689-212207_213154.0458.0Nucleotide bindingNote=ATP
HgeneCHKAchr11:67864486chr11:26734253ENST00000356135-211207_213154.0440.0Nucleotide bindingNote=ATP
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000028046709104_128113.0397.0Topological domainCytoplasmic
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000280467091_9113.0397.0Topological domainExtracellular
TgeneSLC5A12chr11:67864486chr11:26734253ENST000002804670931_47113.0397.0Topological domainCytoplasmic
TgeneSLC5A12chr11:67864486chr11:26734253ENST000002804670969_82113.0397.0Topological domainExtracellular
TgeneSLC5A12chr11:67864486chr11:26734253ENST00000396005015104_128113.0619.0Topological domainCytoplasmic
TgeneSLC5A12chr11:67864486chr11:26734253ENST000003960050151_9113.0619.0Topological domainExtracellular
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000039600501531_47113.0619.0Topological domainCytoplasmic
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000039600501569_82113.0619.0Topological domainExtracellular
TgeneSLC5A12chr11:67864486chr11:26734253ENST000002804670910_30113.0397.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST000002804670948_68113.0397.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST000002804670983_103113.0397.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000039600501510_30113.0619.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000039600501548_68113.0619.0TransmembraneHelical
TgeneSLC5A12chr11:67864486chr11:26734253ENST0000039600501583_103113.0619.0TransmembraneHelical


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Fusion Gene Sequence for CHKA-SLC5A12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000265689_ENST00000396005_TCGA-C8-A1HK-01A_CHKA_chr11_67864486_-_SLC5A12_chr11_26734253_length(transcript)=6090nt_BP=489nt
CCGCGCCTCCTCGGCCGCCTGTCGGGCATGAAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTGAGC
TGCGGTAGCGGCAGCGCGGCCCCGGCGCCCGGCGTGGGGCAGCAGCGCGACGCCGCCAGCGACCTCGAGTCCAAGCAGCTGGGCGGCCAA
CAGCCGCCGCTCGCGCTGCCCCCTCCGCCGCCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAG
CAGCCGGAGCCCCGGACGCGGCGCAGGGCCTATCTGTGGTGCAAGGAGTTCCTGCCCGGCGCCTGGCGGGGCCTCCGCGAGGACGAGTTC
CACATCAGTGTCATCAGAGGCGGCCTTAGCAACATGCTGTTCCAGTGCTCCCTACCTGACACCACAGCCACCCTTGGTGATGAGCCTCGG
AAAGTGCTCCTGCGGCTGTATGGAGCGATTTTGCAGATGTACTTACAACTACGATTCAACAAACCAGTTCGCTATGCTGCCACGGTCATC
TACATTGTACAGACGATTCTCTACACAGGAGTGGTGGTGTATGCTCCTGCCCTGGCACTCAATCAAGTGACTGGGTTTGATCTCTGGGGC
TCTGTGTTTGCAACAGGAATTGTTTGCACATTCTACTGTACCCTGGGAGGATTAAAAGCAGTGGTGTGGACAGATGCATTTCAGATGGTT
GTCATGATTGTGGGCTTCTTAACGGTTCTCATTCAAGGATCAACTCATGCTGGGGGATTCCACAATGTATTAGAGCAATCAACAAATGGA
TCTCGACTACATATATTTGACTTTGATGTAGATCCTCTCAGGCGACACACTTTTTGGACTATCACAGTGGGAGGAACTTTTACTTGGCTC
GGAATCTATGGGGTCAATCAATCAACTATTCAGCGATGCATCTCTTGCAAAACAGAAAAGCATGCTAAGCTTGCCTTGTATTTTAACTTG
CTGGGTCTCTGGATCATTCTGGTGTGTGCTGTCTTCTCTGGCTTAATCATGTACTCTCACTTTAAAGACTGTGACCCTTGGACTTCTGGC
ATCATCTCAGCACCAGACCAGCTGATGCCGTACTTTGTCATGGAGATATTTGCCACAATGCCAGGACTGCCAGGACTTTTTGTGGCTTGT
GCCTTCAGTGGAACTCTGAGCACCGTGGCTTCCAGCATCAATGCCTTGGCAACAGTGACCTTTGAGGATTTTGTCAAGAGCTGTTTTCCT
CATCTCTCCGACAAGCTGAGCACCTGGATCAGTAAAGGCTTATGTCTCTTATTTGGCGTGATGTGTACCTCTATGGCTGTGGCTGCATCT
GTCATGGGAGGTGTTGTGCAGGCTTCCCTCAGCATTCACGGCATGTGTGGAGGACCAATGCTGGGCTTATTCTCCCTGGGAATCGTGTTC
CCTTTTGTGAATTGGAAGGGTGCACTAGGAGGTCTTCTTACTGGAATCACCTTGTCATTTTGGGTGGCCATTGGGGCCTTCATTTACCCT
GCACCAGCCTCTAAGACATGGCCTTTGCCTCTGTCAACAGACCAATGTATCAAATCAAATGTGACAGCAACAGGGCCTCCAGTACTATCC
AGCAGACCTGGAATAGCTGATACCTGGTACTCGATCTCCTACCTTTACTACAGTGCAGTGGGCTGCTTAGGATGCATTGTTGCTGGAGTA
ATCATCAGCCTCATAACAGGTCGCCAAAGAGGTGAGGATATTCAACCACTGTTAATTAGACCAGTTTGTAATTTATTTTGCTTTTGGTCT
AAGAAGTACAAAACACTATGCTGGTGTGGAGTTCAGCATGACAGTGGGACAGAGCAGGAAAACCTTGAGAATGGCAGTGCCCGGAAACAG
GGGGCTGAATCTGTCTTACAGAACGGACTCAGAAGAGAAAGCCTGGTACATGTTCCAGGCTATGATCCTAAGGACAAAAGCTACAACAAT
ATGGCATTTGAGACTACCCATTTCTAAGGCAATACCTGTATGAATGCACACACACACGTGCAATACACACACACACACACAAACTCCACA
TACTTCTTGCCTACTTGTTAGTAGATATGTATAGTTGCCATTGCTAGAAGACAGGGATGTCTGGTGCCTATTTCTACTTATTTATAACTA
CATGCAAAATGACTGTCTCTCGGGATATTCTTTGAAAGACTCCAACTTTCACAGAGAAAAACCAACCTGCTCCAAATGCCCTTGACTACT
TCCTTCTTGAATAAATTAGGGCTGGATTTCATTACCATTCAAGAAAGCGAAGTCTTTTTGCTTGGTGTCATATTAAACTTCAGGTTTTTC
GTTTTAGTAGTTTTTTAACCATCAAAATATCTTGGAGTTTAGAGGCAGAACGGGAAACAGAAATATGCATATTTAACACTTTCCTGCCAC
GAGGGATAAAATAGAGGAATGACATCCACCCCTGACCTCATACCTGACATACATGTAGATATATTTTATGCCACCCATCTCCCATCCTGT
AGCTACAATTGGCATACAACTACTATTAACCTCCCTTCACCACCACTGTCAGGTCCTCTTCCAGTCATTCCAGTCATTAGCTGTCCTGAC
CAAACATTAAAAAAAAAATTCAGCTAAATACAGAAGAAGATGGTATGTCTGGCTAGTGGGAGTGATTATAACTAAAAACTTTGCTCCTTT
TGTGCTGTCCATGCAGTATGTCTTCTTCCTTTCTATCACTTTACAATGAAAAATTGCCTCAGAGCTCAATAAGAAGTCTAGAGCCTTTTT
CCAGGGCTAAGGAAAGAGAAAAGGAATGTCCTATAGAAGGTTGTTAGGATAGAATTTGGTAAAAGAACGTTGCAAATATTGTAACAGACC
ATAGGAGATTTCATCAGCAATAGGATTCTTCTTTGGAGAAAATACATTGTCCATAAGACTTGTACTCTGCTCATTCAACTCATGTGAGCA
AGCTCAACTCACTCCACCTGGGTTAGGTAACAGAAGTGGAGAACTTCATAGTTCGTGTCTAGAAAATAATGTTTAAAGTTCTGGAGAATG
AGGGTATTGCAGATTAAAAGGCGAGTTGACAAATGAAGGAGCAGTGAAAGATTTTTGGAAGAAGTGAAGAAGTGAAATTCTGAAAAGGTA
AAAGAAAGAACCAGTATGTCACAGGGGCCAAGTCAGAGGACAGATAATAAGAAACAAAGTTGTATCTGAGAGTCATATATTAGGACAGGT
GTCAGATATTTATTTTGGTGGCCAGATAAAAGCAAAAGGCCTAGAAACAGTGTGTTAGCAAAGTAAGAAGAAATGGTCCAAATAGGCAAG
GATAAGGAAATCCAAAGGTTGTCTTTAAATATTTCTCAAAAGAGAAAGCCTTGAAAGAAGCATACAATAGAGAAAAAATAAATTACCAGT
ATTTATTATTAGAAAAGATAGAAAGACAGACAAATCAGTGGAGGAATTAAAACAGAGAAACTGGAGTTTATAAAACAGAGCCCAATCCTT
GCCTTCTCTCCCTCCACTCAAATAGAAAAGGAGAATGGAGAAAGAGAAAGAAGGTATTAGGCTACAGTTTATAAGAGAGATGAGAAAAAA
ATACATTTGGGAATAGAGGGAAAGGGTCAAAAGGGGTCACATTTGGAGAAATATCTGAAAATGAGAAGGAGCAGAATTTTTGGAAACATT
TTTTAAAGTCTGGCAACGCTAATTAAGCTGTTGATCTAAGGATTTGCAAATTGAGAGGTGCAATTATTTTCCAAATGATTTGTGACACTC
TTATTAATTAGAATATATATTTTGTGAATATTGAAATCTGAGCCAAAACTAGTTAGCTTTATTAATATCTTAGGGAAAGAAGAGAGAAAG
AAAGAGGGAGGGAGAGAGAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAAGAAGAAAGAAAGAAAGAAAAAGACAGGAAGAGGAAGAG
AGAGACAGAAAGAATAAAAAAACAGCAATTCTGAGGATGAGAATAAATTAATGGTAGGTATTACATATGCATATACATATATATATCTGT
ACACATATATATGTAAATATGATTTGGAATACATCAGGATTGTGAACTTCCACTTGGGATAGCATAAAAGCAAAATATACCATACAATTT
TTCATTTTACTCACAAATTTTACTCACAAATTCTCCTAAAGACATTTCACTAGGTCAGTACATTTCCGAGAAAGTTTTAAAAACGTTTCT
TCTTTTATAGTCCCTAATTATCTTACCTGGAGTGTTATCAAAATGTCATACAACTGGAAAATGCAATTATTATTATAAAAATATCTCTGC
CTTCTCTTGTGTAATGAAATTTATGGCATTAGGAGATGACATTTCAAGAGATTTTAGAGGTCAATGTAGAGACTCCCCCCATTCTTCTTA
ATTGAACAAACATGCATAAATCTAGGGTTTCAGGTAGAGAGCAGATGGGAATCTACAGGAAACTGTCTTCCATAGTGTATGAAAACCGTG
TTTGTTGTGTGGTGAAGCAAAAGGAAACTATGAAGCGCACAGTCAATAGATTCAGCTAGTGAGTCCCAGCACTCCTTTCAGGCCCTCACT
AGGATTAGCAGCCCAGAGTCATGCCAAGGCCACTGGTGCAGTACAAAGACAGTTCAGTGACAAGTTCCATCCATACCATGGAAGAGGGTT
AAACTTGTGGCTGTTTTTGCCACAGCATGACCAGAGACATTCTCAATAAATGGCACTAGGAATGATGAGTTTTAGAGGGGCCTAAAATGT
TCCAAACTTGATACTCACCACTGTACCTTTAAAGCACAACCACAGATATTGGTAAAAATGGAACAGAATTACCTCAATACCTCTTTAACT
CATTCTGTATGAATTCATTTTGATGACAGACATTTTTTGTCACCATTTGGAATAAGAACTACAACAGCTTATGATTGAGGTGAGGAACTG
CAGTCAAATGGCTTAGGTTCAAACACGAGTTCTGACACAAATCTAGGTAATTTTGGGCAATATTTTAAAATCTTAGTTTATTCACCAATT
AATAGGAGTAAAAATTACCCCTACTTAATAGAATTATTATGAAGATTTATATAAGTAAATCATATAAAGTGCTTAGCACAGTGTGACTGG
CCCACATGGAACATTTAATACTTGGTCTGCAGTATATGAAGAAAATGGTGTACATGTTAACTTAAATGGTTTCATTATTTCTCTTCAGGA
TTTTTAAGATGTGGGATCAGAATATATGTTACTATTTTGAGAATTAGAAATAATAAGAAAAACAGAATGTATACATTAAAAGTCATGCCT
AAATTTCCAAAGAGTAGTTTTTTTAATGCCAGAGTTTAAATAAAATATTATTTTCCAGAGAGTAACTTTTCTAAAGGTCCTAAATTCTGA
AAAGAGAGAAAACTACTGTTATAAACAAGTTTATTACTAAAAGATGCAATTCATTACTATGATTTATTATTATTTTGTACATGTAAACCT
TGATAAATAAACAGCATCTCAACCCAAGTTTATTACTCATTGCACAGTTCAAAGCAACTATGACTCTCAAAATAGCAACAGAAGGTGGGG
AGGGTCTTTTCCCTTTGTTTATATAGTATTTGCTAAAAATGAACTTTACTATTTTGTGGCTTTATAGGGTTACACCATTTCATTCTAAAG
AGAAACAAAAAGTAAACCATTGGCCATGTGGCTTTCAAACAGTATTTCAAAGAGAATATTACTGAAATATTTTTGTGCTGTTACAGTCTT
AATCAAACATTATTACAAAGATCAGATACGGAAAAAATAGAGGAGTCTCCCCTTAATTGTTCCCTTTGAAATAAATTGTTTTAAATTATT
ACAGAAGTTATAGCTGTATGTACATGCACATTTGTATATTTACAAGTCTCATGTACTTAATCTCAATATTGCAAATTAGCTAGGTTTACT
ATAGAGTTAACTGCTTTTATCTAGCATTTATAATCTTGTAGTATAACCTATTTTCAAATAACTAAAATTTAATTGATGTCATCAATGGTA

>In-frame_ENST00000265689_ENST00000396005_TCGA-C8-A1HK-01A_CHKA_chr11_67864486_-_SLC5A12_chr11_26734253_length(amino acids)=662AA_start in transcript=18_stop in transcript=2006
MSGMKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRT
RRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMYLQLRFNKPVRYAATVIYIVQTI
LYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGFHNVLEQSTNGSRLHIF
DFDVDPLRRHTFWTITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHFKDCDPWTSGIISAPD
QLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVKSCFPHLSDKLSTWISKGLCLLFGVMCTSMAVAASVMGGVV
QASLSIHGMCGGPMLGLFSLGIVFPFVNWKGALGGLLTGITLSFWVAIGAFIYPAPASKTWPLPLSTDQCIKSNVTATGPPVLSSRPGIA
DTWYSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPLLIRPVCNLFCFWSKKYKTLCWCGVQHDSGTEQENLENGSARKQGAESVL

--------------------------------------------------------------
>In-frame_ENST00000265689_ENST00000280467_TCGA-C8-A1HK-01A_CHKA_chr11_67864486_-_SLC5A12_chr11_26734253_length(transcript)=2134nt_BP=489nt
CCGCGCCTCCTCGGCCGCCTGTCGGGCATGAAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTGAGC
TGCGGTAGCGGCAGCGCGGCCCCGGCGCCCGGCGTGGGGCAGCAGCGCGACGCCGCCAGCGACCTCGAGTCCAAGCAGCTGGGCGGCCAA
CAGCCGCCGCTCGCGCTGCCCCCTCCGCCGCCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAG
CAGCCGGAGCCCCGGACGCGGCGCAGGGCCTATCTGTGGTGCAAGGAGTTCCTGCCCGGCGCCTGGCGGGGCCTCCGCGAGGACGAGTTC
CACATCAGTGTCATCAGAGGCGGCCTTAGCAACATGCTGTTCCAGTGCTCCCTACCTGACACCACAGCCACCCTTGGTGATGAGCCTCGG
AAAGTGCTCCTGCGGCTGTATGGAGCGATTTTGCAGATGTACTTACAACTACGATTCAACAAACCAGTTCGCTATGCTGCCACGGTCATC
TACATTGTACAGACGATTCTCTACACAGGAGTGGTGGTGTATGCTCCTGCCCTGGCACTCAATCAAGTGACTGGGTTTGATCTCTGGGGC
TCTGTGTTTGCAACAGGAATTGTTTGCACATTCTACTGTACCCTGGGAGGATTAAAAGCAGTGGTGTGGACAGATGCATTTCAGATGGTT
GTCATGATTGTGGGCTTCTTAACGGTTCTCATTCAAGGATCAACTCATGCTGGGGGATTCCACAATGTATTAGAGCAATCAACAAATGGA
TCTCGACTACATATATTTGACTTTGATGTAGATCCTCTCAGGCGACACACTTTTTGGACTATCACAGTGGGAGGAACTTTTACTTGGCTC
GGAATCTATGGGGTCAATCAATCAACTATTCAGCGATGCATCTCTTGCAAAACAGAAAAGCATGCTAAGCTTGCCTTGTATTTTAACTTG
CTGGGTCTCTGGATCATTCTGGTGTGTGCTGTCTTCTCTGGCTTAATCATGTACTCTCACTTTAAAGACTGTGACCCTTGGACTTCTGGC
ATCATCTCAGCACCAGACCAGCTGATGCCGTACTTTGTCATGGAGATATTTGCCACAATGCCAGGACTGCCAGGACTTTTTGTGGCTTGT
GCCTTCAGTGGAACTCTGAGCACCGTGGCTTCCAGCATCAATGCCTTGGCAACAGTGACCTTTGAGGATTTTGTCAAGAGCTGTTTTCCT
CATCTCTCCGACAAGCTGAGCACCTGGATCAGTAAAGGCTTATGTAGGTACAGCTGGTGGACTTTCTATTCCATATCATGAAATGTACAT
GTGGTAGATGTCAAAATCCTGCATGTGCTATTCAGGACACACTTATAAACACAAATGCACTGTGAGATATGTGAAGAATCCCACACATAG
ATTCTTACACTTCCAAAGATCCAGCAGGGTATCAGGAAAGAATGACTAGCTAGTTTACCTTAACTGCCTTTATTTTCAGATACTCTTCTA
TACTTACCCTACACTCTAGACGAGGCTTATCCAACCCACGGCCTGTGGGCCGCATACGGCCCAGGATGGCTTTGAATGCAGCCCAACACA
AATTCGTAAACTTTCTTAAAACATTCTGGAATTTTTTTGTAATTTTTTAAATCTTAGCAGCTATCATTAGTGTTTGTGTATTTTATGTGT
ACTCCAAGGCAACTCCTTCTTTCAACGTGGCCCAGGGAGGCCAAAAGATTGGACACCCCTGCAAACTAATCACATCAATCTCTCTTGATT
ACACTGTGTGATGGTCATATTAGTCTCTCTACATGGGAAGATGTTGTGCTTACTATGGCCAGTCACTTTGACAAAGAAAAGCCAAATTCT
TTTCTAAAGAATTGTTCCTTATTACCAAACTCCCAGTAACCCCCTCAAAGAATAATTGCCCCTTGCTTAATCATGCAATTGCATATTATG
TTTATACTCACTTCAGCACTTATCAGAGATAATTGCAGTTTCACAAGGTTTACTTTTTAAAGTATAAACAAATTATGTATTTACTTACTA

>In-frame_ENST00000265689_ENST00000280467_TCGA-C8-A1HK-01A_CHKA_chr11_67864486_-_SLC5A12_chr11_26734253_length(amino acids)=440AA_start in transcript=18_stop in transcript=1340
MSGMKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRT
RRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMYLQLRFNKPVRYAATVIYIVQTI
LYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGFHNVLEQSTNGSRLHIF
DFDVDPLRRHTFWTITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHFKDCDPWTSGIISAPD

--------------------------------------------------------------
>In-frame_ENST00000356135_ENST00000396005_TCGA-C8-A1HK-01A_CHKA_chr11_67864486_-_SLC5A12_chr11_26734253_length(transcript)=6330nt_BP=729nt
GTGGCGAGCGCGAGGGCGGGCTGTGACGCGGCCGGCGCTCCTCGTGCGGCGGCGGCAGAGGAGCGAGTGCAGCGGCCAGCAGCACATCCC
CGCTCCACAGTCGCCGCAGTCGCCGCAGCCGCCGCCGCCGCCCCGCGCGCCCAACCGCCGCGGCCCCCTGCCCCGCCGGCCTGCCAGTGA
GAGAGCGGCGAGGGGGCGCCCGGCCGGACTCTGAGCCTAGTCCTCTCGCGCTGCGGCCGCCCGCGCCTCCTCGGCCGCCTGTCGGGCATG
AAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTGAGCTGCGGTAGCGGCAGCGCGGCCCCGGCGCCC
GGCGTGGGGCAGCAGCGCGACGCCGCCAGCGACCTCGAGTCCAAGCAGCTGGGCGGCCAACAGCCGCCGCTCGCGCTGCCCCCTCCGCCG
CCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAGCAGCCGGAGCCCCGGACGCGGCGCAGGGCC
TATCTGTGGTGCAAGGAGTTCCTGCCCGGCGCCTGGCGGGGCCTCCGCGAGGACGAGTTCCACATCAGTGTCATCAGAGGCGGCCTTAGC
AACATGCTGTTCCAGTGCTCCCTACCTGACACCACAGCCACCCTTGGTGATGAGCCTCGGAAAGTGCTCCTGCGGCTGTATGGAGCGATT
TTGCAGATGTACTTACAACTACGATTCAACAAACCAGTTCGCTATGCTGCCACGGTCATCTACATTGTACAGACGATTCTCTACACAGGA
GTGGTGGTGTATGCTCCTGCCCTGGCACTCAATCAAGTGACTGGGTTTGATCTCTGGGGCTCTGTGTTTGCAACAGGAATTGTTTGCACA
TTCTACTGTACCCTGGGAGGATTAAAAGCAGTGGTGTGGACAGATGCATTTCAGATGGTTGTCATGATTGTGGGCTTCTTAACGGTTCTC
ATTCAAGGATCAACTCATGCTGGGGGATTCCACAATGTATTAGAGCAATCAACAAATGGATCTCGACTACATATATTTGACTTTGATGTA
GATCCTCTCAGGCGACACACTTTTTGGACTATCACAGTGGGAGGAACTTTTACTTGGCTCGGAATCTATGGGGTCAATCAATCAACTATT
CAGCGATGCATCTCTTGCAAAACAGAAAAGCATGCTAAGCTTGCCTTGTATTTTAACTTGCTGGGTCTCTGGATCATTCTGGTGTGTGCT
GTCTTCTCTGGCTTAATCATGTACTCTCACTTTAAAGACTGTGACCCTTGGACTTCTGGCATCATCTCAGCACCAGACCAGCTGATGCCG
TACTTTGTCATGGAGATATTTGCCACAATGCCAGGACTGCCAGGACTTTTTGTGGCTTGTGCCTTCAGTGGAACTCTGAGCACCGTGGCT
TCCAGCATCAATGCCTTGGCAACAGTGACCTTTGAGGATTTTGTCAAGAGCTGTTTTCCTCATCTCTCCGACAAGCTGAGCACCTGGATC
AGTAAAGGCTTATGTCTCTTATTTGGCGTGATGTGTACCTCTATGGCTGTGGCTGCATCTGTCATGGGAGGTGTTGTGCAGGCTTCCCTC
AGCATTCACGGCATGTGTGGAGGACCAATGCTGGGCTTATTCTCCCTGGGAATCGTGTTCCCTTTTGTGAATTGGAAGGGTGCACTAGGA
GGTCTTCTTACTGGAATCACCTTGTCATTTTGGGTGGCCATTGGGGCCTTCATTTACCCTGCACCAGCCTCTAAGACATGGCCTTTGCCT
CTGTCAACAGACCAATGTATCAAATCAAATGTGACAGCAACAGGGCCTCCAGTACTATCCAGCAGACCTGGAATAGCTGATACCTGGTAC
TCGATCTCCTACCTTTACTACAGTGCAGTGGGCTGCTTAGGATGCATTGTTGCTGGAGTAATCATCAGCCTCATAACAGGTCGCCAAAGA
GGTGAGGATATTCAACCACTGTTAATTAGACCAGTTTGTAATTTATTTTGCTTTTGGTCTAAGAAGTACAAAACACTATGCTGGTGTGGA
GTTCAGCATGACAGTGGGACAGAGCAGGAAAACCTTGAGAATGGCAGTGCCCGGAAACAGGGGGCTGAATCTGTCTTACAGAACGGACTC
AGAAGAGAAAGCCTGGTACATGTTCCAGGCTATGATCCTAAGGACAAAAGCTACAACAATATGGCATTTGAGACTACCCATTTCTAAGGC
AATACCTGTATGAATGCACACACACACGTGCAATACACACACACACACACAAACTCCACATACTTCTTGCCTACTTGTTAGTAGATATGT
ATAGTTGCCATTGCTAGAAGACAGGGATGTCTGGTGCCTATTTCTACTTATTTATAACTACATGCAAAATGACTGTCTCTCGGGATATTC
TTTGAAAGACTCCAACTTTCACAGAGAAAAACCAACCTGCTCCAAATGCCCTTGACTACTTCCTTCTTGAATAAATTAGGGCTGGATTTC
ATTACCATTCAAGAAAGCGAAGTCTTTTTGCTTGGTGTCATATTAAACTTCAGGTTTTTCGTTTTAGTAGTTTTTTAACCATCAAAATAT
CTTGGAGTTTAGAGGCAGAACGGGAAACAGAAATATGCATATTTAACACTTTCCTGCCACGAGGGATAAAATAGAGGAATGACATCCACC
CCTGACCTCATACCTGACATACATGTAGATATATTTTATGCCACCCATCTCCCATCCTGTAGCTACAATTGGCATACAACTACTATTAAC
CTCCCTTCACCACCACTGTCAGGTCCTCTTCCAGTCATTCCAGTCATTAGCTGTCCTGACCAAACATTAAAAAAAAAATTCAGCTAAATA
CAGAAGAAGATGGTATGTCTGGCTAGTGGGAGTGATTATAACTAAAAACTTTGCTCCTTTTGTGCTGTCCATGCAGTATGTCTTCTTCCT
TTCTATCACTTTACAATGAAAAATTGCCTCAGAGCTCAATAAGAAGTCTAGAGCCTTTTTCCAGGGCTAAGGAAAGAGAAAAGGAATGTC
CTATAGAAGGTTGTTAGGATAGAATTTGGTAAAAGAACGTTGCAAATATTGTAACAGACCATAGGAGATTTCATCAGCAATAGGATTCTT
CTTTGGAGAAAATACATTGTCCATAAGACTTGTACTCTGCTCATTCAACTCATGTGAGCAAGCTCAACTCACTCCACCTGGGTTAGGTAA
CAGAAGTGGAGAACTTCATAGTTCGTGTCTAGAAAATAATGTTTAAAGTTCTGGAGAATGAGGGTATTGCAGATTAAAAGGCGAGTTGAC
AAATGAAGGAGCAGTGAAAGATTTTTGGAAGAAGTGAAGAAGTGAAATTCTGAAAAGGTAAAAGAAAGAACCAGTATGTCACAGGGGCCA
AGTCAGAGGACAGATAATAAGAAACAAAGTTGTATCTGAGAGTCATATATTAGGACAGGTGTCAGATATTTATTTTGGTGGCCAGATAAA
AGCAAAAGGCCTAGAAACAGTGTGTTAGCAAAGTAAGAAGAAATGGTCCAAATAGGCAAGGATAAGGAAATCCAAAGGTTGTCTTTAAAT
ATTTCTCAAAAGAGAAAGCCTTGAAAGAAGCATACAATAGAGAAAAAATAAATTACCAGTATTTATTATTAGAAAAGATAGAAAGACAGA
CAAATCAGTGGAGGAATTAAAACAGAGAAACTGGAGTTTATAAAACAGAGCCCAATCCTTGCCTTCTCTCCCTCCACTCAAATAGAAAAG
GAGAATGGAGAAAGAGAAAGAAGGTATTAGGCTACAGTTTATAAGAGAGATGAGAAAAAAATACATTTGGGAATAGAGGGAAAGGGTCAA
AAGGGGTCACATTTGGAGAAATATCTGAAAATGAGAAGGAGCAGAATTTTTGGAAACATTTTTTAAAGTCTGGCAACGCTAATTAAGCTG
TTGATCTAAGGATTTGCAAATTGAGAGGTGCAATTATTTTCCAAATGATTTGTGACACTCTTATTAATTAGAATATATATTTTGTGAATA
TTGAAATCTGAGCCAAAACTAGTTAGCTTTATTAATATCTTAGGGAAAGAAGAGAGAAAGAAAGAGGGAGGGAGAGAGAGAAAGAAAGAA
AGAAAGAAAGAAAGAAAGAAAAGAAGAAAGAAAGAAAGAAAAAGACAGGAAGAGGAAGAGAGAGACAGAAAGAATAAAAAAACAGCAATT
CTGAGGATGAGAATAAATTAATGGTAGGTATTACATATGCATATACATATATATATCTGTACACATATATATGTAAATATGATTTGGAAT
ACATCAGGATTGTGAACTTCCACTTGGGATAGCATAAAAGCAAAATATACCATACAATTTTTCATTTTACTCACAAATTTTACTCACAAA
TTCTCCTAAAGACATTTCACTAGGTCAGTACATTTCCGAGAAAGTTTTAAAAACGTTTCTTCTTTTATAGTCCCTAATTATCTTACCTGG
AGTGTTATCAAAATGTCATACAACTGGAAAATGCAATTATTATTATAAAAATATCTCTGCCTTCTCTTGTGTAATGAAATTTATGGCATT
AGGAGATGACATTTCAAGAGATTTTAGAGGTCAATGTAGAGACTCCCCCCATTCTTCTTAATTGAACAAACATGCATAAATCTAGGGTTT
CAGGTAGAGAGCAGATGGGAATCTACAGGAAACTGTCTTCCATAGTGTATGAAAACCGTGTTTGTTGTGTGGTGAAGCAAAAGGAAACTA
TGAAGCGCACAGTCAATAGATTCAGCTAGTGAGTCCCAGCACTCCTTTCAGGCCCTCACTAGGATTAGCAGCCCAGAGTCATGCCAAGGC
CACTGGTGCAGTACAAAGACAGTTCAGTGACAAGTTCCATCCATACCATGGAAGAGGGTTAAACTTGTGGCTGTTTTTGCCACAGCATGA
CCAGAGACATTCTCAATAAATGGCACTAGGAATGATGAGTTTTAGAGGGGCCTAAAATGTTCCAAACTTGATACTCACCACTGTACCTTT
AAAGCACAACCACAGATATTGGTAAAAATGGAACAGAATTACCTCAATACCTCTTTAACTCATTCTGTATGAATTCATTTTGATGACAGA
CATTTTTTGTCACCATTTGGAATAAGAACTACAACAGCTTATGATTGAGGTGAGGAACTGCAGTCAAATGGCTTAGGTTCAAACACGAGT
TCTGACACAAATCTAGGTAATTTTGGGCAATATTTTAAAATCTTAGTTTATTCACCAATTAATAGGAGTAAAAATTACCCCTACTTAATA
GAATTATTATGAAGATTTATATAAGTAAATCATATAAAGTGCTTAGCACAGTGTGACTGGCCCACATGGAACATTTAATACTTGGTCTGC
AGTATATGAAGAAAATGGTGTACATGTTAACTTAAATGGTTTCATTATTTCTCTTCAGGATTTTTAAGATGTGGGATCAGAATATATGTT
ACTATTTTGAGAATTAGAAATAATAAGAAAAACAGAATGTATACATTAAAAGTCATGCCTAAATTTCCAAAGAGTAGTTTTTTTAATGCC
AGAGTTTAAATAAAATATTATTTTCCAGAGAGTAACTTTTCTAAAGGTCCTAAATTCTGAAAAGAGAGAAAACTACTGTTATAAACAAGT
TTATTACTAAAAGATGCAATTCATTACTATGATTTATTATTATTTTGTACATGTAAACCTTGATAAATAAACAGCATCTCAACCCAAGTT
TATTACTCATTGCACAGTTCAAAGCAACTATGACTCTCAAAATAGCAACAGAAGGTGGGGAGGGTCTTTTCCCTTTGTTTATATAGTATT
TGCTAAAAATGAACTTTACTATTTTGTGGCTTTATAGGGTTACACCATTTCATTCTAAAGAGAAACAAAAAGTAAACCATTGGCCATGTG
GCTTTCAAACAGTATTTCAAAGAGAATATTACTGAAATATTTTTGTGCTGTTACAGTCTTAATCAAACATTATTACAAAGATCAGATACG
GAAAAAATAGAGGAGTCTCCCCTTAATTGTTCCCTTTGAAATAAATTGTTTTAAATTATTACAGAAGTTATAGCTGTATGTACATGCACA
TTTGTATATTTACAAGTCTCATGTACTTAATCTCAATATTGCAAATTAGCTAGGTTTACTATAGAGTTAACTGCTTTTATCTAGCATTTA
TAATCTTGTAGTATAACCTATTTTCAAATAACTAAAATTTAATTGATGTCATCAATGGTACACATGAAAATGATACAAATTTATAAACTA

>In-frame_ENST00000356135_ENST00000396005_TCGA-C8-A1HK-01A_CHKA_chr11_67864486_-_SLC5A12_chr11_26734253_length(amino acids)=678AA_start in transcript=210_stop in transcript=2246
MSLVLSRCGRPRLLGRLSGMKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQ
PPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMYLQLRFN
KPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGF
HNVLEQSTNGSRLHIFDFDVDPLRRHTFWTITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSH
FKDCDPWTSGIISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVKSCFPHLSDKLSTWISKGLCLLFGV
MCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVFPFVNWKGALGGLLTGITLSFWVAIGAFIYPAPASKTWPLPLSTDQCIKSN
VTATGPPVLSSRPGIADTWYSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPLLIRPVCNLFCFWSKKYKTLCWCGVQHDSGTEQE

--------------------------------------------------------------
>In-frame_ENST00000356135_ENST00000280467_TCGA-C8-A1HK-01A_CHKA_chr11_67864486_-_SLC5A12_chr11_26734253_length(transcript)=2374nt_BP=729nt
GTGGCGAGCGCGAGGGCGGGCTGTGACGCGGCCGGCGCTCCTCGTGCGGCGGCGGCAGAGGAGCGAGTGCAGCGGCCAGCAGCACATCCC
CGCTCCACAGTCGCCGCAGTCGCCGCAGCCGCCGCCGCCGCCCCGCGCGCCCAACCGCCGCGGCCCCCTGCCCCGCCGGCCTGCCAGTGA
GAGAGCGGCGAGGGGGCGCCCGGCCGGACTCTGAGCCTAGTCCTCTCGCGCTGCGGCCGCCCGCGCCTCCTCGGCCGCCTGTCGGGCATG
AAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTGAGCTGCGGTAGCGGCAGCGCGGCCCCGGCGCCC
GGCGTGGGGCAGCAGCGCGACGCCGCCAGCGACCTCGAGTCCAAGCAGCTGGGCGGCCAACAGCCGCCGCTCGCGCTGCCCCCTCCGCCG
CCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAGCAGCCGGAGCCCCGGACGCGGCGCAGGGCC
TATCTGTGGTGCAAGGAGTTCCTGCCCGGCGCCTGGCGGGGCCTCCGCGAGGACGAGTTCCACATCAGTGTCATCAGAGGCGGCCTTAGC
AACATGCTGTTCCAGTGCTCCCTACCTGACACCACAGCCACCCTTGGTGATGAGCCTCGGAAAGTGCTCCTGCGGCTGTATGGAGCGATT
TTGCAGATGTACTTACAACTACGATTCAACAAACCAGTTCGCTATGCTGCCACGGTCATCTACATTGTACAGACGATTCTCTACACAGGA
GTGGTGGTGTATGCTCCTGCCCTGGCACTCAATCAAGTGACTGGGTTTGATCTCTGGGGCTCTGTGTTTGCAACAGGAATTGTTTGCACA
TTCTACTGTACCCTGGGAGGATTAAAAGCAGTGGTGTGGACAGATGCATTTCAGATGGTTGTCATGATTGTGGGCTTCTTAACGGTTCTC
ATTCAAGGATCAACTCATGCTGGGGGATTCCACAATGTATTAGAGCAATCAACAAATGGATCTCGACTACATATATTTGACTTTGATGTA
GATCCTCTCAGGCGACACACTTTTTGGACTATCACAGTGGGAGGAACTTTTACTTGGCTCGGAATCTATGGGGTCAATCAATCAACTATT
CAGCGATGCATCTCTTGCAAAACAGAAAAGCATGCTAAGCTTGCCTTGTATTTTAACTTGCTGGGTCTCTGGATCATTCTGGTGTGTGCT
GTCTTCTCTGGCTTAATCATGTACTCTCACTTTAAAGACTGTGACCCTTGGACTTCTGGCATCATCTCAGCACCAGACCAGCTGATGCCG
TACTTTGTCATGGAGATATTTGCCACAATGCCAGGACTGCCAGGACTTTTTGTGGCTTGTGCCTTCAGTGGAACTCTGAGCACCGTGGCT
TCCAGCATCAATGCCTTGGCAACAGTGACCTTTGAGGATTTTGTCAAGAGCTGTTTTCCTCATCTCTCCGACAAGCTGAGCACCTGGATC
AGTAAAGGCTTATGTAGGTACAGCTGGTGGACTTTCTATTCCATATCATGAAATGTACATGTGGTAGATGTCAAAATCCTGCATGTGCTA
TTCAGGACACACTTATAAACACAAATGCACTGTGAGATATGTGAAGAATCCCACACATAGATTCTTACACTTCCAAAGATCCAGCAGGGT
ATCAGGAAAGAATGACTAGCTAGTTTACCTTAACTGCCTTTATTTTCAGATACTCTTCTATACTTACCCTACACTCTAGACGAGGCTTAT
CCAACCCACGGCCTGTGGGCCGCATACGGCCCAGGATGGCTTTGAATGCAGCCCAACACAAATTCGTAAACTTTCTTAAAACATTCTGGA
ATTTTTTTGTAATTTTTTAAATCTTAGCAGCTATCATTAGTGTTTGTGTATTTTATGTGTACTCCAAGGCAACTCCTTCTTTCAACGTGG
CCCAGGGAGGCCAAAAGATTGGACACCCCTGCAAACTAATCACATCAATCTCTCTTGATTACACTGTGTGATGGTCATATTAGTCTCTCT
ACATGGGAAGATGTTGTGCTTACTATGGCCAGTCACTTTGACAAAGAAAAGCCAAATTCTTTTCTAAAGAATTGTTCCTTATTACCAAAC
TCCCAGTAACCCCCTCAAAGAATAATTGCCCCTTGCTTAATCATGCAATTGCATATTATGTTTATACTCACTTCAGCACTTATCAGAGAT
AATTGCAGTTTCACAAGGTTTACTTTTTAAAGTATAAACAAATTATGTATTTACTTACTAATAGAAAATATAGGTAATTTGGGGAAATTT

>In-frame_ENST00000356135_ENST00000280467_TCGA-C8-A1HK-01A_CHKA_chr11_67864486_-_SLC5A12_chr11_26734253_length(amino acids)=456AA_start in transcript=210_stop in transcript=1580
MSLVLSRCGRPRLLGRLSGMKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQ
PPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMYLQLRFN
KPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGF
HNVLEQSTNGSRLHIFDFDVDPLRRHTFWTITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSH
FKDCDPWTSGIISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVKSCFPHLSDKLSTWISKGLCRYSWW

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHKA-SLC5A12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHKA-SLC5A12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHKA-SLC5A12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHKAC0038219Status Dysraphicus1CTD_human
HgeneCHKAC0080178Spina Bifida1CTD_human
HgeneCHKAC0266508Rachischisis1CTD_human