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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CHORDC1-NARS2 (FusionGDB2 ID:16630)

Fusion Gene Summary for CHORDC1-NARS2

Fusion gene summary

Fusion gene information	Fusion gene name: CHORDC1-NARS2
	Fusion gene ID: 16630
		Hgene	Tgene
	Gene symbol	CHORDC1	NARS2
	Gene ID	26973	79731
	Gene name	cysteine and histidine rich domain containing 1	asparaginyl-tRNA synthetase 2, mitochondrial
	Synonyms	CHP1	DFNB94\|SLM5\|asnRS
	Cytomap	11q14.3	11q14.1
	Type of gene	protein-coding	protein-coding
	Description	cysteine and histidine-rich domain-containing protein 1CHORD-containing protein 1CHP-1chord domain-containing protein 1cysteine and histidine-rich domain (CHORD) containing 1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein	probable asparagine--tRNA ligase, mitochondrialasparagine tRNA ligase 2, mitochondrial (putative)asparaginyl-tRNA synthetase 2, mitochondrial (putative)deafness, autosomal recessive 94probable asparaginyl-tRNA synthetase, mitochondrial
	Modification date	20200313	20200313
	UniProtAcc	Q9UHD1	Q96I59
	Ensembl transtripts involved in fusion gene	ENST00000320585, ENST00000529987, ENST00000457199, ENST00000529726, ENST00000530765,	ENST00000281038, ENST00000528850,
Fusion gene scores	* DoF score	4 X 4 X 2=32	29 X 15 X 11=4785
	# samples	4	37
	** MAII score	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(37/4785*10)=-3.69292174885708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CHORDC1 [Title/Abstract] AND NARS2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CHORDC1(89951303)-NARS2(78154804), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CHORDC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NARS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-EQ-A4SO-01A	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-

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Fusion Gene ORF analysis for CHORDC1-NARS2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000320585	ENST00000281038	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-
In-frame	ENST00000320585	ENST00000528850	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-
intron-3CDS	ENST00000529987	ENST00000281038	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-
intron-3CDS	ENST00000529987	ENST00000528850	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-
In-frame	ENST00000457199	ENST00000281038	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-
In-frame	ENST00000457199	ENST00000528850	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-
intron-3CDS	ENST00000529726	ENST00000281038	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-
intron-3CDS	ENST00000529726	ENST00000528850	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-
In-frame	ENST00000530765	ENST00000281038	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-
In-frame	ENST00000530765	ENST00000528850	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000320585	CHORDC1	chr11	89951303	-	ENST00000281038	NARS2	chr11	78154804	-	1503	524	0	521	173
ENST00000320585	CHORDC1	chr11	89951303	-	ENST00000528850	NARS2	chr11	78154804	-	1241	524	0	521	173
ENST00000457199	CHORDC1	chr11	89951303	-	ENST00000281038	NARS2	chr11	78154804	-	1198	219	105	488	127
ENST00000457199	CHORDC1	chr11	89951303	-	ENST00000528850	NARS2	chr11	78154804	-	936	219	105	488	127
ENST00000530765	CHORDC1	chr11	89951303	-	ENST00000281038	NARS2	chr11	78154804	-	1216	237	123	506	127
ENST00000530765	CHORDC1	chr11	89951303	-	ENST00000528850	NARS2	chr11	78154804	-	954	237	123	506	127

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000320585	ENST00000281038	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-	0.5159897	0.48401025
ENST00000320585	ENST00000528850	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-	0.41547477	0.5845252
ENST00000457199	ENST00000281038	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-	0.017562494	0.98243743
ENST00000457199	ENST00000528850	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-	0.01788725	0.98211277
ENST00000530765	ENST00000281038	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-	0.017146975	0.982853
ENST00000530765	ENST00000528850	CHORDC1	chr11	89951303	-	NARS2	chr11	78154804	-	0.019616233	0.9803838

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Fusion Genomic Features for CHORDC1-NARS2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHORDC1-NARS2

Go to
FGviewer for the breakpoints of chr11:89951303-chr11:78154804
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CHORDC1 Q9UHD1	NARS2 Q96I59
FUNCTION: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755). {ECO:0000269\|PubMed:20230755, ECO:0000269\|PubMed:32053105}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHORDC1

chr11:89951303

chr11:78154804

ENST00000320585

157_216

38.0

333.0

Domain

CHORD 2

Hgene

CHORDC1

chr11:89951303

chr11:78154804

ENST00000320585

227_316

38.0

333.0

Domain

Hgene

CHORDC1

chr11:89951303

chr11:78154804

ENST00000320585

5_64

38.0

333.0

Domain

CHORD 1

Hgene

CHORDC1

chr11:89951303

chr11:78154804

ENST00000457199

157_216

38.0

314.0

Domain

CHORD 2

Hgene

CHORDC1

chr11:89951303

chr11:78154804

ENST00000457199

227_316

38.0

314.0

Domain

Hgene

CHORDC1

chr11:89951303

chr11:78154804

ENST00000457199

5_64

38.0

314.0

Domain

CHORD 1

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Fusion Gene Sequence for CHORDC1-NARS2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000320585_ENST00000281038_TCGA-EQ-A4SO-01A_CHORDC1_chr11_89951303_-_NARS2_chr11_78154804_length(transcript)=1503nt_BP=524nt
ATGAGAGGGCGGGGCGGCCACTTTGCTGCAGGAGATACCCAAAGCCAGTTAGCACTGAGGAAGTCAGAAGAGAATTGTCAGTCTCTCGGA
CACCTTCATTTTCTGCCCCGGAAATTTCTCCTCCGCTGTTGTCTGGGCTCCACTTCCGACCCCCAGTTGCTACCAGCTGTAGTCCGACCT
ATCGTGGCCCGGGCTAGTGCCAGCCTCCCGCCGCTACCTCCGCCTCGTCCCTTCTCCTCTGCGCCTGCGCGACCGGAAAATTCGCGAAGG
TTCCTGAAACGCAACGGATCGTTTCCGGAAGCCGGTAGCCGCCTCAGTCGTCAGACCGGTGCTAGCGACACGGGAGTGGCAAACGCATCC
TCTTGCCGTTCCCGGTGTTTGGGCCTTGCCTGTGACGGTGGGAAAAGAAAATGGCCTTGCTGTGCTACAACCGGGGCTGCGGTCAGCGCT
TCGATCCTGAGACCAATTCCGACGATGCTTGCACATACCACCCAGGTGTTCCGGTCTTTCACGATGCATTAAAGGTTGCTGCTGTTGATC
TTCTGGTTCCTGGAGTTGGGGAACTCTTTGGAGGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCCAGATCGGGAC
TTACAGAAGTCTACCAATGGTATCTGGACCTTCGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTGAACGCTACCTGC
AGTGCATCTTGGGTGTTGACAATATCAAAGATGTTATCCCTTTCCCAAGGTTTCCTCATTCATGCCTTTTATAGCTGGAAGATTGGTTAA
GGAAAAGCACCCCCCATGGCAGAGACACTGCACATGATTGTGCATACAGCAGAATGCATGTTTGGATTTTAGAAATGCAGATTTCAATAT
GTAATTGTTGTGCCATAAGATATCATAGAAAAAATATAAGTGGTTGTGATTTTCTTAGAAAGTTGAGGGTATTTCACGTAAGGATGAGCT
CCCGCAAGAAGAGGTACTTATAGCAAGGGGACTCTCAAATCCATTACCTCAATTAAGAAATGAAGAAATTGAATTAGTCTCAAAGTTTCT
TTTAAACTCTAAAACAGAATGAGATAATGTATTTTACGTTGTCTATAATCATTAAATCACTCCCTGTGTAATTTGTGAGAACCATCTAGT
AGCTCGAAATAAAATAATGTTGCATCTTTTCTCCCTTGCCATATACTTTGTGATAAATCCTTATCTCATTTTCAGTACTTCATTAAACAT
TGCAGAAAAAAATATTCCTTAAGGTCTTAATTGATTTAAAGAAGTAGCTATTCTGAATTGAAATCTCCTTTCATTGAACTGGATGAAAAA
ATCATGTTTAATAACTGTTGCTTTTCAATTTTCAAAGCTGTTGAGATATTACATTAAGTATTTCAACTCTTTAATCACTGTTGTTATAAT

>In-frame_ENST00000320585_ENST00000281038_TCGA-EQ-A4SO-01A_CHORDC1_chr11_89951303_-_NARS2_chr11_78154804_length(amino acids)=173AA_start in transcript=0_stop in transcript=521
MRGRGGHFAAGDTQSQLALRKSEENCQSLGHLHFLPRKFLLRCCLGSTSDPQLLPAVVRPIVARASASLPPLPPPRPFSSAPARPENSRR

--------------------------------------------------------------
>In-frame_ENST00000320585_ENST00000528850_TCGA-EQ-A4SO-01A_CHORDC1_chr11_89951303_-_NARS2_chr11_78154804_length(transcript)=1241nt_BP=524nt
ATGAGAGGGCGGGGCGGCCACTTTGCTGCAGGAGATACCCAAAGCCAGTTAGCACTGAGGAAGTCAGAAGAGAATTGTCAGTCTCTCGGA
CACCTTCATTTTCTGCCCCGGAAATTTCTCCTCCGCTGTTGTCTGGGCTCCACTTCCGACCCCCAGTTGCTACCAGCTGTAGTCCGACCT
ATCGTGGCCCGGGCTAGTGCCAGCCTCCCGCCGCTACCTCCGCCTCGTCCCTTCTCCTCTGCGCCTGCGCGACCGGAAAATTCGCGAAGG
TTCCTGAAACGCAACGGATCGTTTCCGGAAGCCGGTAGCCGCCTCAGTCGTCAGACCGGTGCTAGCGACACGGGAGTGGCAAACGCATCC
TCTTGCCGTTCCCGGTGTTTGGGCCTTGCCTGTGACGGTGGGAAAAGAAAATGGCCTTGCTGTGCTACAACCGGGGCTGCGGTCAGCGCT
TCGATCCTGAGACCAATTCCGACGATGCTTGCACATACCACCCAGGTGTTCCGGTCTTTCACGATGCATTAAAGGTTGCTGCTGTTGATC
TTCTGGTTCCTGGAGTTGGGGAACTCTTTGGAGGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCCAGATCGGGAC
TTACAGAAGTCTACCAATGGTATCTGGACCTTCGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTGAACGCTACCTGC
AGTGCATCTTGGGTGTTGACAATATCAAAGATGTTATCCCTTTCCCAAGGTTTCCTCATTCATGCCTTTTATAGCTGGAAGATTGGTTAA
GGAAAAGCACCCCCCATGGCAGAGACACTGCACATGATTGTGCATACAGCAGAATGCATGTTTGGATTTTAGAAATGCAGATTTCAATAT
GTAATTGTTGTGCCATAAGATATCATAGAAAAAATATAAGTGGTTGTGATTTTCTTAGAAAGTTGAGGGTATTTCACGTAAGGATGAGCT
CCCGCAAGAAGAGGTACTTATAGCAAGGGGACTCTCAAATCCATTACCTCAATTAAGAAATGAAGAAATTGAATTAGTCTCAAAGTTTCT
TTTAAACTCTAAAACAGAATGAGATAATGTATTTTACGTTGTCTATAATCATTAAATCACTCCCTGTGTAATTTGTGAGAACCATCTAGT

>In-frame_ENST00000320585_ENST00000528850_TCGA-EQ-A4SO-01A_CHORDC1_chr11_89951303_-_NARS2_chr11_78154804_length(amino acids)=173AA_start in transcript=0_stop in transcript=521
MRGRGGHFAAGDTQSQLALRKSEENCQSLGHLHFLPRKFLLRCCLGSTSDPQLLPAVVRPIVARASASLPPLPPPRPFSSAPARPENSRR

--------------------------------------------------------------
>In-frame_ENST00000457199_ENST00000281038_TCGA-EQ-A4SO-01A_CHORDC1_chr11_89951303_-_NARS2_chr11_78154804_length(transcript)=1198nt_BP=219nt
TAGCCGCCTCAGTCGTCAGACCGGTGCTAGCGACACGGGAGTGGCAAACGCATCCTCTTGCCGTTCCCGGTGTTTGGGCCTTGCCTGTGA
CGGTGGGAAAAGAAAATGGCCTTGCTGTGCTACAACCGGGGCTGCGGTCAGCGCTTCGATCCTGAGACCAATTCCGACGATGCTTGCACA
TACCACCCAGGTGTTCCGGTCTTTCACGATGCATTAAAGGTTGCTGCTGTTGATCTTCTGGTTCCTGGAGTTGGGGAACTCTTTGGAGGA
GGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCCAGATCGGGACTTACAGAAGTCTACCAATGGTATCTGGACCTTCGT
CGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTGAACGCTACCTGCAGTGCATCTTGGGTGTTGACAATATCAAAGATGTT
ATCCCTTTCCCAAGGTTTCCTCATTCATGCCTTTTATAGCTGGAAGATTGGTTAAGGAAAAGCACCCCCCATGGCAGAGACACTGCACAT
GATTGTGCATACAGCAGAATGCATGTTTGGATTTTAGAAATGCAGATTTCAATATGTAATTGTTGTGCCATAAGATATCATAGAAAAAAT
ATAAGTGGTTGTGATTTTCTTAGAAAGTTGAGGGTATTTCACGTAAGGATGAGCTCCCGCAAGAAGAGGTACTTATAGCAAGGGGACTCT
CAAATCCATTACCTCAATTAAGAAATGAAGAAATTGAATTAGTCTCAAAGTTTCTTTTAAACTCTAAAACAGAATGAGATAATGTATTTT
ACGTTGTCTATAATCATTAAATCACTCCCTGTGTAATTTGTGAGAACCATCTAGTAGCTCGAAATAAAATAATGTTGCATCTTTTCTCCC
TTGCCATATACTTTGTGATAAATCCTTATCTCATTTTCAGTACTTCATTAAACATTGCAGAAAAAAATATTCCTTAAGGTCTTAATTGAT
TTAAAGAAGTAGCTATTCTGAATTGAAATCTCCTTTCATTGAACTGGATGAAAAAATCATGTTTAATAACTGTTGCTTTTCAATTTTCAA
AGCTGTTGAGATATTACATTAAGTATTTCAACTCTTTAATCACTGTTGTTATAATTTGTTTATATTTGATGTTTATAATTTGTCTAATAA

>In-frame_ENST00000457199_ENST00000281038_TCGA-EQ-A4SO-01A_CHORDC1_chr11_89951303_-_NARS2_chr11_78154804_length(amino acids)=127AA_start in transcript=105_stop in transcript=488
MALLCYNRGCGQRFDPETNSDDACTYHPGVPVFHDALKVAAVDLLVPGVGELFGGGLREERYHFLEERLARSGLTEVYQWYLDLRRFGSV

--------------------------------------------------------------
>In-frame_ENST00000457199_ENST00000528850_TCGA-EQ-A4SO-01A_CHORDC1_chr11_89951303_-_NARS2_chr11_78154804_length(transcript)=936nt_BP=219nt
TAGCCGCCTCAGTCGTCAGACCGGTGCTAGCGACACGGGAGTGGCAAACGCATCCTCTTGCCGTTCCCGGTGTTTGGGCCTTGCCTGTGA
CGGTGGGAAAAGAAAATGGCCTTGCTGTGCTACAACCGGGGCTGCGGTCAGCGCTTCGATCCTGAGACCAATTCCGACGATGCTTGCACA
TACCACCCAGGTGTTCCGGTCTTTCACGATGCATTAAAGGTTGCTGCTGTTGATCTTCTGGTTCCTGGAGTTGGGGAACTCTTTGGAGGA
GGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCCAGATCGGGACTTACAGAAGTCTACCAATGGTATCTGGACCTTCGT
CGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTGAACGCTACCTGCAGTGCATCTTGGGTGTTGACAATATCAAAGATGTT
ATCCCTTTCCCAAGGTTTCCTCATTCATGCCTTTTATAGCTGGAAGATTGGTTAAGGAAAAGCACCCCCCATGGCAGAGACACTGCACAT
GATTGTGCATACAGCAGAATGCATGTTTGGATTTTAGAAATGCAGATTTCAATATGTAATTGTTGTGCCATAAGATATCATAGAAAAAAT
ATAAGTGGTTGTGATTTTCTTAGAAAGTTGAGGGTATTTCACGTAAGGATGAGCTCCCGCAAGAAGAGGTACTTATAGCAAGGGGACTCT
CAAATCCATTACCTCAATTAAGAAATGAAGAAATTGAATTAGTCTCAAAGTTTCTTTTAAACTCTAAAACAGAATGAGATAATGTATTTT
ACGTTGTCTATAATCATTAAATCACTCCCTGTGTAATTTGTGAGAACCATCTAGTAGCTCGAAATAAAATAATGTTGCATCTTTTCTCCC

>In-frame_ENST00000457199_ENST00000528850_TCGA-EQ-A4SO-01A_CHORDC1_chr11_89951303_-_NARS2_chr11_78154804_length(amino acids)=127AA_start in transcript=105_stop in transcript=488
MALLCYNRGCGQRFDPETNSDDACTYHPGVPVFHDALKVAAVDLLVPGVGELFGGGLREERYHFLEERLARSGLTEVYQWYLDLRRFGSV

--------------------------------------------------------------
>In-frame_ENST00000530765_ENST00000281038_TCGA-EQ-A4SO-01A_CHORDC1_chr11_89951303_-_NARS2_chr11_78154804_length(transcript)=1216nt_BP=237nt
ATCGTTTCCGGAAGCCGGTAGCCGCCTCAGTCGTCAGACCGGTGCTAGCGACACGGGAGTGGCAAACGCATCCTCTTGCCGTTCCCGGTG
TTTGGGCCTTGCCTGTGACGGTGGGAAAAGAAAATGGCCTTGCTGTGCTACAACCGGGGCTGCGGTCAGCGCTTCGATCCTGAGACCAAT
TCCGACGATGCTTGCACATACCACCCAGGTGTTCCGGTCTTTCACGATGCATTAAAGGTTGCTGCTGTTGATCTTCTGGTTCCTGGAGTT
GGGGAACTCTTTGGAGGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCCAGATCGGGACTTACAGAAGTCTACCAA
TGGTATCTGGACCTTCGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTGAACGCTACCTGCAGTGCATCTTGGGTGTT
GACAATATCAAAGATGTTATCCCTTTCCCAAGGTTTCCTCATTCATGCCTTTTATAGCTGGAAGATTGGTTAAGGAAAAGCACCCCCCAT
GGCAGAGACACTGCACATGATTGTGCATACAGCAGAATGCATGTTTGGATTTTAGAAATGCAGATTTCAATATGTAATTGTTGTGCCATA
AGATATCATAGAAAAAATATAAGTGGTTGTGATTTTCTTAGAAAGTTGAGGGTATTTCACGTAAGGATGAGCTCCCGCAAGAAGAGGTAC
TTATAGCAAGGGGACTCTCAAATCCATTACCTCAATTAAGAAATGAAGAAATTGAATTAGTCTCAAAGTTTCTTTTAAACTCTAAAACAG
AATGAGATAATGTATTTTACGTTGTCTATAATCATTAAATCACTCCCTGTGTAATTTGTGAGAACCATCTAGTAGCTCGAAATAAAATAA
TGTTGCATCTTTTCTCCCTTGCCATATACTTTGTGATAAATCCTTATCTCATTTTCAGTACTTCATTAAACATTGCAGAAAAAAATATTC
CTTAAGGTCTTAATTGATTTAAAGAAGTAGCTATTCTGAATTGAAATCTCCTTTCATTGAACTGGATGAAAAAATCATGTTTAATAACTG
TTGCTTTTCAATTTTCAAAGCTGTTGAGATATTACATTAAGTATTTCAACTCTTTAATCACTGTTGTTATAATTTGTTTATATTTGATGT

>In-frame_ENST00000530765_ENST00000281038_TCGA-EQ-A4SO-01A_CHORDC1_chr11_89951303_-_NARS2_chr11_78154804_length(amino acids)=127AA_start in transcript=123_stop in transcript=506
MALLCYNRGCGQRFDPETNSDDACTYHPGVPVFHDALKVAAVDLLVPGVGELFGGGLREERYHFLEERLARSGLTEVYQWYLDLRRFGSV

--------------------------------------------------------------
>In-frame_ENST00000530765_ENST00000528850_TCGA-EQ-A4SO-01A_CHORDC1_chr11_89951303_-_NARS2_chr11_78154804_length(transcript)=954nt_BP=237nt
ATCGTTTCCGGAAGCCGGTAGCCGCCTCAGTCGTCAGACCGGTGCTAGCGACACGGGAGTGGCAAACGCATCCTCTTGCCGTTCCCGGTG
TTTGGGCCTTGCCTGTGACGGTGGGAAAAGAAAATGGCCTTGCTGTGCTACAACCGGGGCTGCGGTCAGCGCTTCGATCCTGAGACCAAT
TCCGACGATGCTTGCACATACCACCCAGGTGTTCCGGTCTTTCACGATGCATTAAAGGTTGCTGCTGTTGATCTTCTGGTTCCTGGAGTT
GGGGAACTCTTTGGAGGAGGCCTCAGAGAAGAACGATACCATTTCTTAGAGGAGCGCTTAGCCAGATCGGGACTTACAGAAGTCTACCAA
TGGTATCTGGACCTTCGTCGATTTGGATCTGTGCCACATGGAGGTTTTGGGATGGGATTTGAACGCTACCTGCAGTGCATCTTGGGTGTT
GACAATATCAAAGATGTTATCCCTTTCCCAAGGTTTCCTCATTCATGCCTTTTATAGCTGGAAGATTGGTTAAGGAAAAGCACCCCCCAT
GGCAGAGACACTGCACATGATTGTGCATACAGCAGAATGCATGTTTGGATTTTAGAAATGCAGATTTCAATATGTAATTGTTGTGCCATA
AGATATCATAGAAAAAATATAAGTGGTTGTGATTTTCTTAGAAAGTTGAGGGTATTTCACGTAAGGATGAGCTCCCGCAAGAAGAGGTAC
TTATAGCAAGGGGACTCTCAAATCCATTACCTCAATTAAGAAATGAAGAAATTGAATTAGTCTCAAAGTTTCTTTTAAACTCTAAAACAG
AATGAGATAATGTATTTTACGTTGTCTATAATCATTAAATCACTCCCTGTGTAATTTGTGAGAACCATCTAGTAGCTCGAAATAAAATAA

>In-frame_ENST00000530765_ENST00000528850_TCGA-EQ-A4SO-01A_CHORDC1_chr11_89951303_-_NARS2_chr11_78154804_length(amino acids)=127AA_start in transcript=123_stop in transcript=506
MALLCYNRGCGQRFDPETNSDDACTYHPGVPVFHDALKVAAVDLLVPGVGELFGGGLREERYHFLEERLARSGLTEVYQWYLDLRRFGSV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHORDC1-NARS2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CHORDC1	chr11:89951303	chr11:78154804	ENST00000320585	-	2	11	65_316	38.0	333.0	HSP90AA1 and HSP90AB1
Hgene	CHORDC1	chr11:89951303	chr11:78154804	ENST00000457199	-	2	10	65_316	38.0	314.0	HSP90AA1 and HSP90AB1
Hgene	CHORDC1	chr11:89951303	chr11:78154804	ENST00000320585	-	2	11	2_77	38.0	333.0	PPP5C
Hgene	CHORDC1	chr11:89951303	chr11:78154804	ENST00000457199	-	2	10	2_77	38.0	314.0	PPP5C

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CHORDC1-NARS2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	NARS2	Q96I59	DB00174	Asparagine		Small molecule	Approved\|Investigational\|Nutraceutical

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Related Diseases for CHORDC1-NARS2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	NARS2	C4015643	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 24	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	NARS2	C0023264	Leigh Disease	2	CLINGEN
Tgene	NARS2	C1838951	LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY	2	CLINGEN
Tgene	NARS2	C1850597	Leigh Syndrome Due To Mitochondrial Complex II Deficiency	2	CLINGEN
Tgene	NARS2	C1850598	Leigh Syndrome due to Mitochondrial Complex III Deficiency	2	CLINGEN
Tgene	NARS2	C1850599	Leigh Syndrome due to Mitochondrial Complex IV Deficiency	2	CLINGEN
Tgene	NARS2	C1850600	Leigh Syndrome due to Mitochondrial Complex V Deficiency	2	CLINGEN
Tgene	NARS2	C2931891	Necrotizing encephalopathy, infantile subacute, of Leigh	2	CLINGEN
Tgene	NARS2	C0036572	Seizures	1	GENOMICS_ENGLAND
Tgene	NARS2	C3711374	Nonsyndromic Deafness	1	CLINGEN