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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CHST11-HSP90B1 (FusionGDB2 ID:16713) |
Fusion Gene Summary for CHST11-HSP90B1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHST11-HSP90B1 | Fusion gene ID: 16713 | Hgene | Tgene | Gene symbol | CHST11 | HSP90B1 | Gene ID | 50515 | 7184 |
| Gene name | carbohydrate sulfotransferase 11 | heat shock protein 90 beta family member 1 | |
| Synonyms | C4ST|C4ST-1|C4ST1|HSA269537|OCBMD | ECGP|GP96|GRP94|HEL-S-125m|HEL35|TRA1 | |
| Cytomap | 12q23.3 | 12q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | carbohydrate sulfotransferase 11C4S-1IgH/CHST11 fusioncarbohydrate (chondroitin 4) sulfotransferase 11chondroitin 4-O-sulfotransferase 1 | endoplasmin94 kDa glucose-regulated proteinendothelial cell (HBMEC) glycoproteinepididymis luminal protein 35epididymis secretory sperm binding protein Li 125mheat shock protein 90 kDa beta member 1heat shock protein 90kDa beta (Grp94), member 1hea | |
| Modification date | 20200313 | 20200320 | |
| UniProtAcc | . | P14625 | |
| Ensembl transtripts involved in fusion gene | ENST00000547956, ENST00000549260, ENST00000303694, ENST00000546689, ENST00000550711, | ENST00000299767, | |
| Fusion gene scores | * DoF score | 13 X 8 X 6=624 | 21 X 21 X 8=3528 |
| # samples | 15 | 25 | |
| ** MAII score | log2(15/624*10)=-2.05658352836637 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(25/3528*10)=-3.81885056089543 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CHST11 [Title/Abstract] AND HSP90B1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CHST11(104995769)-HSP90B1(104333287), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CHST11 | GO:0030206 | chondroitin sulfate biosynthetic process | 11056388 |
| Tgene | HSP90B1 | GO:0001666 | response to hypoxia | 15620698 |
| Tgene | HSP90B1 | GO:0031247 | actin rod assembly | 19000834 |
| Tgene | HSP90B1 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 19000834 |
| Tgene | HSP90B1 | GO:0071318 | cellular response to ATP | 19000834 |
| Fusion gene breakpoints across CHST11 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across HSP90B1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-23-1028-01A | CHST11 | chr12 | 104995769 | + | HSP90B1 | chr12 | 104333287 | + |
| ChimerDB4 | OV | TCGA-23-1028-01A | CHST11 | chr12 | 104995769 | + | HSP90B1 | chr12 | 104333287 | + |
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Fusion Gene ORF analysis for CHST11-HSP90B1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000547956 | ENST00000299767 | CHST11 | chr12 | 104995769 | + | HSP90B1 | chr12 | 104333287 | + |
| In-frame | ENST00000549260 | ENST00000299767 | CHST11 | chr12 | 104995769 | + | HSP90B1 | chr12 | 104333287 | + |
| In-frame | ENST00000303694 | ENST00000299767 | CHST11 | chr12 | 104995769 | + | HSP90B1 | chr12 | 104333287 | + |
| In-frame | ENST00000546689 | ENST00000299767 | CHST11 | chr12 | 104995769 | + | HSP90B1 | chr12 | 104333287 | + |
| intron-3CDS | ENST00000550711 | ENST00000299767 | CHST11 | chr12 | 104995769 | + | HSP90B1 | chr12 | 104333287 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000547956 | CHST11 | chr12 | 104995769 | + | ENST00000299767 | HSP90B1 | chr12 | 104333287 | + | 2551 | 850 | 814 | 2286 | 490 |
| ENST00000549260 | CHST11 | chr12 | 104995769 | + | ENST00000299767 | HSP90B1 | chr12 | 104333287 | + | 2331 | 630 | 12 | 2066 | 684 |
| ENST00000303694 | CHST11 | chr12 | 104995769 | + | ENST00000299767 | HSP90B1 | chr12 | 104333287 | + | 2344 | 643 | 10 | 2079 | 689 |
| ENST00000546689 | CHST11 | chr12 | 104995769 | + | ENST00000299767 | HSP90B1 | chr12 | 104333287 | + | 2371 | 670 | 700 | 2106 | 468 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000547956 | ENST00000299767 | CHST11 | chr12 | 104995769 | + | HSP90B1 | chr12 | 104333287 | + | 0.000506149 | 0.99949384 |
| ENST00000549260 | ENST00000299767 | CHST11 | chr12 | 104995769 | + | HSP90B1 | chr12 | 104333287 | + | 0.001145799 | 0.99885416 |
| ENST00000303694 | ENST00000299767 | CHST11 | chr12 | 104995769 | + | HSP90B1 | chr12 | 104333287 | + | 0.001691926 | 0.99830806 |
| ENST00000546689 | ENST00000299767 | CHST11 | chr12 | 104995769 | + | HSP90B1 | chr12 | 104333287 | + | 0.000510725 | 0.9994893 |
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Fusion Genomic Features for CHST11-HSP90B1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| CHST11 | chr12 | 104995769 | + | HSP90B1 | chr12 | 104333286 | + | 0.00099587 | 0.9990042 |
| CHST11 | chr12 | 104995769 | + | HSP90B1 | chr12 | 104333286 | + | 0.00099587 | 0.9990042 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CHST11-HSP90B1 |
| Go to FGviewer for the breakpoints of chr12:104995769-chr12:104333287 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | HSP90B1 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). Has ATPase activity (By similarity). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000250|UniProtKB:P08113, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:32272059}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CHST11 | chr12:104995769 | chr12:104333287 | ENST00000303694 | + | 2 | 3 | 1_16 | 68.0 | 353.0 | Topological domain | Cytoplasmic |
| Hgene | CHST11 | chr12:104995769 | chr12:104333287 | ENST00000549260 | + | 2 | 3 | 1_16 | 63.0 | 348.0 | Topological domain | Cytoplasmic |
| Hgene | CHST11 | chr12:104995769 | chr12:104333287 | ENST00000303694 | + | 2 | 3 | 17_37 | 68.0 | 353.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | CHST11 | chr12:104995769 | chr12:104333287 | ENST00000549260 | + | 2 | 3 | 17_37 | 63.0 | 348.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | HSP90B1 | chr12:104995769 | chr12:104333287 | ENST00000299767 | 6 | 18 | 800_803 | 325.0 | 804.0 | Motif | Note=Prevents secretion from ER |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CHST11 | chr12:104995769 | chr12:104333287 | ENST00000303694 | + | 2 | 3 | 124_130 | 68.0 | 353.0 | Nucleotide binding | PAPS |
| Hgene | CHST11 | chr12:104995769 | chr12:104333287 | ENST00000303694 | + | 2 | 3 | 186_194 | 68.0 | 353.0 | Nucleotide binding | PAPS |
| Hgene | CHST11 | chr12:104995769 | chr12:104333287 | ENST00000549260 | + | 2 | 3 | 124_130 | 63.0 | 348.0 | Nucleotide binding | PAPS |
| Hgene | CHST11 | chr12:104995769 | chr12:104333287 | ENST00000549260 | + | 2 | 3 | 186_194 | 63.0 | 348.0 | Nucleotide binding | PAPS |
| Hgene | CHST11 | chr12:104995769 | chr12:104333287 | ENST00000303694 | + | 2 | 3 | 38_352 | 68.0 | 353.0 | Topological domain | Lumenal |
| Hgene | CHST11 | chr12:104995769 | chr12:104333287 | ENST00000549260 | + | 2 | 3 | 38_352 | 63.0 | 348.0 | Topological domain | Lumenal |
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Fusion Gene Sequence for CHST11-HSP90B1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000547956_ENST00000299767_TCGA-23-1028-01A_CHST11_chr12_104995769_+_HSP90B1_chr12_104333287_length(transcript)=2551nt_BP=850nt GGAATATATAGATCGTTGGAGCGCAATGAAGTAGCCTTTGGAGAGAAGGGAGAGGGCCCGTCGGACAGCCACAGCGGCCAGCGCAGCGGC AGCGGCGGCGGCACCACCATCACCGCTCGCACCCCAGCCGCCCGGCCCGCGACCAGGCAGCGGCGGCCGCCGGCGGGATCGGAGGAGGCG GCGGAGCGGCGAGGAGGAGGAGCAGGAGCGCGCAGCCAGCGGGTCCACGCATCTCAGCACTTCCAGACCAACTCCGGCACCTTCCACACC CCTGCCCGGGCTGGGGGCTCCGAGAGCGGCCGCGAAGCGACTCCGATCCTCCCTCTGAGCCTTGCTCAGCTCTGCCCCGCGCCTCCCGGG CTCCGGTCCGCGCGGCGGGGTCCCTGCTCCTGCGCCCCGGGCGCGCTTCCCGGACACCCCGGTCCCCGCAGCCAGGACAAAGCCATGAAG CCAGCGCTGCTGGAAGTGATGAGGATGAACAGAATCTGCCGGATGGTGCTGGCCACTTGCTTGGGATCCTTTATCCTGGTCATCTTCTAT TTCCAAAGTATGTTGCACCCAGGTAAGCTTCAAGCACTCTGTCAGCATGTGAATTTTTTTTTTTTGTAGGTATGGATACTAAAAACTCTA AAATTGTGGTCTTTGGGGGATTTAAAACTTCCTTTCACAGCCTGGCATTTTACCTTCAGTGGTTGCTTTCTCCGTCACCCTTTTTCTATG TAGCATCTCTGAAAAATCTAGCAGGGGATGTTTAGAATTAGAGAAATGCCTAGGTTTAGTGCTAAGCATTCAGACCTGCCCAGGGTTTGA ACTCCTGAGATTAACAGTCTCAAGTTCGAGCAATGGGACTGTTGAAAAAACTGTCTGGGACTGGGAACTTATGAATGATATCAAACCAAT ATGGCAGAGACCATCAAAAGAAGTAGAAGAAGATGAATACAAAGCTTTCTACAAATCATTTTCAAAGGAAAGTGATGACCCCATGGCTTA TATTCACTTTACTGCTGAAGGGGAAGTTACCTTCAAATCAATTTTATTTGTACCCACATCTGCTCCACGTGGTCTGTTTGACGAATATGG ATCTAAAAAGAGCGATTACATTAAGCTCTATGTGCGCCGTGTATTCATCACAGACGACTTCCATGATATGATGCCTAAATACCTCAATTT TGTCAAGGGTGTGGTGGACTCAGATGATCTCCCCTTGAATGTTTCCCGCGAGACTCTTCAGCAACATAAACTGCTTAAGGTGATTAGGAA GAAGCTTGTTCGTAAAACGCTGGACATGATCAAGAAGATTGCTGATGATAAATACAATGATACTTTTTGGAAAGAATTTGGTACCAACAT CAAGCTTGGTGTGATTGAAGACCACTCGAATCGAACACGTCTTGCTAAACTTCTTAGGTTCCAGTCTTCTCATCATCCAACTGACATTAC TAGCCTAGACCAGTATGTGGAAAGAATGAAGGAAAAACAAGACAAAATCTACTTCATGGCTGGGTCCAGCAGAAAAGAGGCTGAATCTTC TCCATTTGTTGAGCGACTTCTGAAAAAGGGCTATGAAGTTATTTACCTCACAGAACCTGTGGATGAATACTGTATTCAGGCCCTTCCCGA ATTTGATGGGAAGAGGTTCCAGAATGTTGCCAAGGAAGGAGTGAAGTTCGATGAAAGTGAGAAAACTAAGGAGAGTCGTGAAGCAGTTGA GAAAGAATTTGAGCCTCTGCTGAATTGGATGAAAGATAAAGCCCTTAAGGACAAGATTGAAAAGGCTGTGGTGTCTCAGCGCCTGACAGA ATCTCCGTGTGCTTTGGTGGCCAGCCAGTACGGATGGTCTGGCAACATGGAGAGAATCATGAAAGCACAAGCGTACCAAACGGGCAAGGA CATCTCTACAAATTACTATGCGAGTCAGAAGAAAACATTTGAAATTAATCCCAGACACCCGCTGATCAGAGACATGCTTCGACGAATTAA GGAAGATGAAGATGATAAAACAGTTTTGGATCTTGCTGTGGTTTTGTTTGAAACAGCAACGCTTCGGTCAGGGTATCTTTTACCAGACAC TAAAGCATATGGAGATAGAATAGAAAGAATGCTTCGCCTCAGTTTGAACATTGACCCTGATGCAAAGGTGGAAGAAGAGCCCGAAGAAGA ACCTGAAGAGACAGCAGAAGACACAACAGAAGACACAGAGCAAGACGAAGATGAAGAAATGGATGTGGGAACAGATGAAGAAGAAGAAAC AGCAAAGGAATCTACAGCTGAAAAAGATGAATTGTAAATTATACTCTCACCATTTGGATCCTGTGTGGAGAGGGAATGTGAAATTTACAT CATTTCTTTTTGGGAGAGACTTGTTTTGGATGCCCCCTAATCCCCTTCTCCCCTGCACTGTAAAATGTGGGATTATGGGTCACAGGAAAA AGTGGGTTTTTTAGTTGAATTTTTTTTAACATTCCTCATGAATGTAAATTTGTACTATTTAACTGACTATTCTTGATGTAAAATCTTGTC >In-frame_ENST00000547956_ENST00000299767_TCGA-23-1028-01A_CHST11_chr12_104995769_+_HSP90B1_chr12_104333287_length(amino acids)=490AA_start in transcript=814_stop in transcript=2286 MRLTVSSSSNGTVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGS KKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIK LGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEF DGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDI STNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEP -------------------------------------------------------------- >In-frame_ENST00000549260_ENST00000299767_TCGA-23-1028-01A_CHST11_chr12_104995769_+_HSP90B1_chr12_104333287_length(transcript)=2331nt_BP=630nt ATATATAGATCGTTGGAGCGCAATGAAGTAGCCTTTGGAGAGAAGGGAGAGGGCCCGTCGGACAGCCACAGCGGCCAGCGCAGCGGCAGC GGCGGCGGCACCACCATCACCGCTCGCACCCCAGCCGCCCGGCCCGCGACCAGGCAGCGGCGGCCGCCGGCGGGATCGGAGGAGGCGGCG GAGCGGCGAGGAGGAGGAGCAGGAGCGCGCAGCCAGCGGGTCCACGCATCTCAGCACTTCCAGACCAACTCCGGCACCTTCCACACCCCT GCCCGGGCTGGGGGCTCCGAGAGCGGCCGCGAAGCGACTCCGATCCTCCCTCTGAGCCTTGCTCAGCTCTGCCCCGCGCCTCCCGGGCTC CGGTCCGCGCGGCGGGGTCCCTGCTCCTGCGCCCCGGGCGCGCTTCCCGGACACCCCGGTCCCCGCAGCCAGGACAAAGCCATGAAGCCA GCGCTGCTGGAAGTGATGAGGATGAACAGAATCTGCCGGATGGTGCTGGCCACTTGCTTGGGATCCTTTATCCTGGTCATCTTCTATTTC CAAATCATGCGGAGGAATCCCTTTGGTGTGGACATCTGCTGCCGGAAGGGGTCCCGAAGCCCCCTGCAGGAACTCTACAACCCAATCCAG GTTGAAAAAACTGTCTGGGACTGGGAACTTATGAATGATATCAAACCAATATGGCAGAGACCATCAAAAGAAGTAGAAGAAGATGAATAC AAAGCTTTCTACAAATCATTTTCAAAGGAAAGTGATGACCCCATGGCTTATATTCACTTTACTGCTGAAGGGGAAGTTACCTTCAAATCA ATTTTATTTGTACCCACATCTGCTCCACGTGGTCTGTTTGACGAATATGGATCTAAAAAGAGCGATTACATTAAGCTCTATGTGCGCCGT GTATTCATCACAGACGACTTCCATGATATGATGCCTAAATACCTCAATTTTGTCAAGGGTGTGGTGGACTCAGATGATCTCCCCTTGAAT GTTTCCCGCGAGACTCTTCAGCAACATAAACTGCTTAAGGTGATTAGGAAGAAGCTTGTTCGTAAAACGCTGGACATGATCAAGAAGATT GCTGATGATAAATACAATGATACTTTTTGGAAAGAATTTGGTACCAACATCAAGCTTGGTGTGATTGAAGACCACTCGAATCGAACACGT CTTGCTAAACTTCTTAGGTTCCAGTCTTCTCATCATCCAACTGACATTACTAGCCTAGACCAGTATGTGGAAAGAATGAAGGAAAAACAA GACAAAATCTACTTCATGGCTGGGTCCAGCAGAAAAGAGGCTGAATCTTCTCCATTTGTTGAGCGACTTCTGAAAAAGGGCTATGAAGTT ATTTACCTCACAGAACCTGTGGATGAATACTGTATTCAGGCCCTTCCCGAATTTGATGGGAAGAGGTTCCAGAATGTTGCCAAGGAAGGA GTGAAGTTCGATGAAAGTGAGAAAACTAAGGAGAGTCGTGAAGCAGTTGAGAAAGAATTTGAGCCTCTGCTGAATTGGATGAAAGATAAA GCCCTTAAGGACAAGATTGAAAAGGCTGTGGTGTCTCAGCGCCTGACAGAATCTCCGTGTGCTTTGGTGGCCAGCCAGTACGGATGGTCT GGCAACATGGAGAGAATCATGAAAGCACAAGCGTACCAAACGGGCAAGGACATCTCTACAAATTACTATGCGAGTCAGAAGAAAACATTT GAAATTAATCCCAGACACCCGCTGATCAGAGACATGCTTCGACGAATTAAGGAAGATGAAGATGATAAAACAGTTTTGGATCTTGCTGTG GTTTTGTTTGAAACAGCAACGCTTCGGTCAGGGTATCTTTTACCAGACACTAAAGCATATGGAGATAGAATAGAAAGAATGCTTCGCCTC AGTTTGAACATTGACCCTGATGCAAAGGTGGAAGAAGAGCCCGAAGAAGAACCTGAAGAGACAGCAGAAGACACAACAGAAGACACAGAG CAAGACGAAGATGAAGAAATGGATGTGGGAACAGATGAAGAAGAAGAAACAGCAAAGGAATCTACAGCTGAAAAAGATGAATTGTAAATT ATACTCTCACCATTTGGATCCTGTGTGGAGAGGGAATGTGAAATTTACATCATTTCTTTTTGGGAGAGACTTGTTTTGGATGCCCCCTAA TCCCCTTCTCCCCTGCACTGTAAAATGTGGGATTATGGGTCACAGGAAAAAGTGGGTTTTTTAGTTGAATTTTTTTTAACATTCCTCATG >In-frame_ENST00000549260_ENST00000299767_TCGA-23-1028-01A_CHST11_chr12_104995769_+_HSP90B1_chr12_104333287_length(amino acids)=684AA_start in transcript=12_stop in transcript=2066 MERNEVAFGEKGEGPSDSHSGQRSGSGGGTTITARTPAARPATRQRRPPAGSEEAAERRGGGAGARSQRVHASQHFQTNSGTFHTPARAG GSESGREATPILPLSLAQLCPAPPGLRSARRGPCSCAPGALPGHPGPRSQDKAMKPALLEVMRMNRICRMVLATCLGSFILVIFYFQIMR RNPFGVDICCRKGSRSPLQELYNPIQVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFV PTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDK YNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLT EPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNME RIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNI -------------------------------------------------------------- >In-frame_ENST00000303694_ENST00000299767_TCGA-23-1028-01A_CHST11_chr12_104995769_+_HSP90B1_chr12_104333287_length(transcript)=2344nt_BP=643nt ATATAGATCGTTGGAGCGCAATGAAGTAGCCTTTGGAGAGAAGGGAGAGGGCCCGTCGGACAGCCACAGCGGCCAGCGCAGCGGCAGCGG CGGCGGCACCACCATCACCGCTCGCACCCCAGCCGCCCGGCCCGCGACCAGGCAGCGGCGGCCGCCGGCGGGATCGGAGGAGGCGGCGGA GCGGCGAGGAGGAGGAGCAGGAGCGCGCAGCCAGCGGGTCCACGCATCTCAGCACTTCCAGACCAACTCCGGCACCTTCCACACCCCTGC CCGGGCTGGGGGCTCCGAGAGCGGCCGCGAAGCGACTCCGATCCTCCCTCTGAGCCTTGCTCAGCTCTGCCCCGCGCCTCCCGGGCTCCG GTCCGCGCGGCGGGGTCCCTGCTCCTGCGCCCCGGGCGCGCTTCCCGGACACCCCGGTCCCCGCAGCCAGGACAAAGCCATGAAGCCAGC GCTGCTGGAAGTGATGAGGATGAACAGAATCTGCCGGATGGTGCTGGCCACTTGCTTGGGATCCTTTATCCTGGTCATCTTCTATTTCCA AAGTATGTTGCACCCAGTCATGCGGAGGAATCCCTTTGGTGTGGACATCTGCTGCCGGAAGGGGTCCCGAAGCCCCCTGCAGGAACTCTA CAACCCAATCCAGGTTGAAAAAACTGTCTGGGACTGGGAACTTATGAATGATATCAAACCAATATGGCAGAGACCATCAAAAGAAGTAGA AGAAGATGAATACAAAGCTTTCTACAAATCATTTTCAAAGGAAAGTGATGACCCCATGGCTTATATTCACTTTACTGCTGAAGGGGAAGT TACCTTCAAATCAATTTTATTTGTACCCACATCTGCTCCACGTGGTCTGTTTGACGAATATGGATCTAAAAAGAGCGATTACATTAAGCT CTATGTGCGCCGTGTATTCATCACAGACGACTTCCATGATATGATGCCTAAATACCTCAATTTTGTCAAGGGTGTGGTGGACTCAGATGA TCTCCCCTTGAATGTTTCCCGCGAGACTCTTCAGCAACATAAACTGCTTAAGGTGATTAGGAAGAAGCTTGTTCGTAAAACGCTGGACAT GATCAAGAAGATTGCTGATGATAAATACAATGATACTTTTTGGAAAGAATTTGGTACCAACATCAAGCTTGGTGTGATTGAAGACCACTC GAATCGAACACGTCTTGCTAAACTTCTTAGGTTCCAGTCTTCTCATCATCCAACTGACATTACTAGCCTAGACCAGTATGTGGAAAGAAT GAAGGAAAAACAAGACAAAATCTACTTCATGGCTGGGTCCAGCAGAAAAGAGGCTGAATCTTCTCCATTTGTTGAGCGACTTCTGAAAAA GGGCTATGAAGTTATTTACCTCACAGAACCTGTGGATGAATACTGTATTCAGGCCCTTCCCGAATTTGATGGGAAGAGGTTCCAGAATGT TGCCAAGGAAGGAGTGAAGTTCGATGAAAGTGAGAAAACTAAGGAGAGTCGTGAAGCAGTTGAGAAAGAATTTGAGCCTCTGCTGAATTG GATGAAAGATAAAGCCCTTAAGGACAAGATTGAAAAGGCTGTGGTGTCTCAGCGCCTGACAGAATCTCCGTGTGCTTTGGTGGCCAGCCA GTACGGATGGTCTGGCAACATGGAGAGAATCATGAAAGCACAAGCGTACCAAACGGGCAAGGACATCTCTACAAATTACTATGCGAGTCA GAAGAAAACATTTGAAATTAATCCCAGACACCCGCTGATCAGAGACATGCTTCGACGAATTAAGGAAGATGAAGATGATAAAACAGTTTT GGATCTTGCTGTGGTTTTGTTTGAAACAGCAACGCTTCGGTCAGGGTATCTTTTACCAGACACTAAAGCATATGGAGATAGAATAGAAAG AATGCTTCGCCTCAGTTTGAACATTGACCCTGATGCAAAGGTGGAAGAAGAGCCCGAAGAAGAACCTGAAGAGACAGCAGAAGACACAAC AGAAGACACAGAGCAAGACGAAGATGAAGAAATGGATGTGGGAACAGATGAAGAAGAAGAAACAGCAAAGGAATCTACAGCTGAAAAAGA TGAATTGTAAATTATACTCTCACCATTTGGATCCTGTGTGGAGAGGGAATGTGAAATTTACATCATTTCTTTTTGGGAGAGACTTGTTTT GGATGCCCCCTAATCCCCTTCTCCCCTGCACTGTAAAATGTGGGATTATGGGTCACAGGAAAAAGTGGGTTTTTTAGTTGAATTTTTTTT AACATTCCTCATGAATGTAAATTTGTACTATTTAACTGACTATTCTTGATGTAAAATCTTGTCATGTGTATAAAAATAAAAAAGATCCCA >In-frame_ENST00000303694_ENST00000299767_TCGA-23-1028-01A_CHST11_chr12_104995769_+_HSP90B1_chr12_104333287_length(amino acids)=689AA_start in transcript=10_stop in transcript=2079 MERNEVAFGEKGEGPSDSHSGQRSGSGGGTTITARTPAARPATRQRRPPAGSEEAAERRGGGAGARSQRVHASQHFQTNSGTFHTPARAG GSESGREATPILPLSLAQLCPAPPGLRSARRGPCSCAPGALPGHPGPRSQDKAMKPALLEVMRMNRICRMVLATCLGSFILVIFYFQSML HPVMRRNPFGVDICCRKGSRSPLQELYNPIQVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFK SILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKK IADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYE VIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGW SGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLR -------------------------------------------------------------- >In-frame_ENST00000546689_ENST00000299767_TCGA-23-1028-01A_CHST11_chr12_104995769_+_HSP90B1_chr12_104333287_length(transcript)=2371nt_BP=670nt GCCTTTGGAGAGAAGGGAGAGGGCCCGTCGGACAGCCACAGCGGCCAGCGCAGCGGCAGCGGCGGCGGCACCACCATCACCGCTCGCACC CCAGCCGCCCGGCCCGCGACCAGGCAGCGGCGGCCGCCGGCGGGATCGGAGGAGGCGGCGGAGCGGCGAGGAGGAGGAGCAGGAGCGCGC AGCCAGCGGGTCCACGCATCTCAGCACTTCCAGACCAACTCCGGCACCTTCCACACCCCTGCCCGGGCTGGGGGCTCCGAGAGCGGCCGC GAAGCGACTCCGATCCTCCCTCTGAGCCTTGCTCAGCTCTGCCCCGCGCCTCCCGGGCTCCGGTCCGCGCGGCGGGGTCCCTGCTCCTGC GCCCCGGGCGCGCTTCCCGGACACCCCGGTCCCCGCAGCCAGGACAAAGCCATGAAGCCAGCGCTGCTGGAAGTGATGAGGATGAACAGA ATCTGCCGGATGGTGCTGGCCACTTGCTTGGGATCCTTTATCCTGGTCATCTTCTATTTCCAAAGTAAGCTTCAAGCACTCTGTCAGCAT GTGAATTTTTTTTTTTTGTAGGTATGGATACTAAAAACTCTAAAATTGTGGTCTTTGGGGGATTTAAAACTTCCTTTCACAGCCTGGCAT TTTACCTTCAGTGGTTGCTTTCTCCGTCACCCTTTTTCTAGTTGAAAAAACTGTCTGGGACTGGGAACTTATGAATGATATCAAACCAAT ATGGCAGAGACCATCAAAAGAAGTAGAAGAAGATGAATACAAAGCTTTCTACAAATCATTTTCAAAGGAAAGTGATGACCCCATGGCTTA TATTCACTTTACTGCTGAAGGGGAAGTTACCTTCAAATCAATTTTATTTGTACCCACATCTGCTCCACGTGGTCTGTTTGACGAATATGG ATCTAAAAAGAGCGATTACATTAAGCTCTATGTGCGCCGTGTATTCATCACAGACGACTTCCATGATATGATGCCTAAATACCTCAATTT TGTCAAGGGTGTGGTGGACTCAGATGATCTCCCCTTGAATGTTTCCCGCGAGACTCTTCAGCAACATAAACTGCTTAAGGTGATTAGGAA GAAGCTTGTTCGTAAAACGCTGGACATGATCAAGAAGATTGCTGATGATAAATACAATGATACTTTTTGGAAAGAATTTGGTACCAACAT CAAGCTTGGTGTGATTGAAGACCACTCGAATCGAACACGTCTTGCTAAACTTCTTAGGTTCCAGTCTTCTCATCATCCAACTGACATTAC TAGCCTAGACCAGTATGTGGAAAGAATGAAGGAAAAACAAGACAAAATCTACTTCATGGCTGGGTCCAGCAGAAAAGAGGCTGAATCTTC TCCATTTGTTGAGCGACTTCTGAAAAAGGGCTATGAAGTTATTTACCTCACAGAACCTGTGGATGAATACTGTATTCAGGCCCTTCCCGA ATTTGATGGGAAGAGGTTCCAGAATGTTGCCAAGGAAGGAGTGAAGTTCGATGAAAGTGAGAAAACTAAGGAGAGTCGTGAAGCAGTTGA GAAAGAATTTGAGCCTCTGCTGAATTGGATGAAAGATAAAGCCCTTAAGGACAAGATTGAAAAGGCTGTGGTGTCTCAGCGCCTGACAGA ATCTCCGTGTGCTTTGGTGGCCAGCCAGTACGGATGGTCTGGCAACATGGAGAGAATCATGAAAGCACAAGCGTACCAAACGGGCAAGGA CATCTCTACAAATTACTATGCGAGTCAGAAGAAAACATTTGAAATTAATCCCAGACACCCGCTGATCAGAGACATGCTTCGACGAATTAA GGAAGATGAAGATGATAAAACAGTTTTGGATCTTGCTGTGGTTTTGTTTGAAACAGCAACGCTTCGGTCAGGGTATCTTTTACCAGACAC TAAAGCATATGGAGATAGAATAGAAAGAATGCTTCGCCTCAGTTTGAACATTGACCCTGATGCAAAGGTGGAAGAAGAGCCCGAAGAAGA ACCTGAAGAGACAGCAGAAGACACAACAGAAGACACAGAGCAAGACGAAGATGAAGAAATGGATGTGGGAACAGATGAAGAAGAAGAAAC AGCAAAGGAATCTACAGCTGAAAAAGATGAATTGTAAATTATACTCTCACCATTTGGATCCTGTGTGGAGAGGGAATGTGAAATTTACAT CATTTCTTTTTGGGAGAGACTTGTTTTGGATGCCCCCTAATCCCCTTCTCCCCTGCACTGTAAAATGTGGGATTATGGGTCACAGGAAAA AGTGGGTTTTTTAGTTGAATTTTTTTTAACATTCCTCATGAATGTAAATTTGTACTATTTAACTGACTATTCTTGATGTAAAATCTTGTC >In-frame_ENST00000546689_ENST00000299767_TCGA-23-1028-01A_CHST11_chr12_104995769_+_HSP90B1_chr12_104333287_length(amino acids)=468AA_start in transcript=700_stop in transcript=2106 MNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDM MPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSS HHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTK ESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIR DMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CHST11-HSP90B1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CHST11-HSP90B1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | HSP90B1 | P14625 | DB00615 | Rifabutin | Other/unknown | Small molecule | Approved|Investigational |
| Tgene | HSP90B1 | P14625 | DB00615 | Rifabutin | Other/unknown | Small molecule | Approved|Investigational |
| Tgene | HSP90B1 | P14625 | DB00615 | Rifabutin | Other/unknown | Small molecule | Approved|Investigational |
| Tgene | HSP90B1 | P14625 | DB09130 | Copper | Small molecule | Approved|Investigational | |
| Tgene | HSP90B1 | P14625 | DB09130 | Copper | Small molecule | Approved|Investigational | |
| Tgene | HSP90B1 | P14625 | DB09130 | Copper | Small molecule | Approved|Investigational |
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Related Diseases for CHST11-HSP90B1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | HSP90B1 | C0005586 | Bipolar Disorder | 3 | PSYGENET |
| Tgene | HSP90B1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | HSP90B1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
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