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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHST9-AQP4 (FusionGDB2 ID:16745)

Fusion Gene Summary for CHST9-AQP4

check button Fusion gene summary
Fusion gene informationFusion gene name: CHST9-AQP4
Fusion gene ID: 16745
HgeneTgene
Gene symbol

CHST9

AQP4

Gene ID

83539

361

Gene namecarbohydrate sulfotransferase 9aquaporin 4
SynonymsGALNAC4ST-2|GalNAc4ST2MIWC|WCH4
Cytomap

18q11.2

18q11.2

Type of geneprotein-codingprotein-coding
Descriptioncarbohydrate sulfotransferase 9GalNAc-4-sulfotransferase 2N-acetylgalactosamine 4-O-sulfotransferase 2carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9galNAc-4-O-sulfotransferase 2aquaporin-4aquaporin type4mercurial-insensitive water channel
Modification date2020031320200329
UniProtAcc

Q7L1S5

P55087

Ensembl transtripts involved in fusion geneENST00000284224, ENST00000581714, 
ENST00000580774, 		ENST00000383168, 
ENST00000581374, ENST00000440832, 
ENST00000583022, 
Fusion gene scores* DoF score6 X 5 X 4=1205 X 3 X 4=60
# samples 76
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/60*10)=0
Context

PubMed: CHST9 [Title/Abstract] AND AQP4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHST9(24604080)-AQP4(24442560), # samples:2
Anticipated loss of major functional domain due to fusion event.CHST9-AQP4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CHST9-AQP4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHST9

GO:0006790

sulfur compound metabolic process

11445554

TgeneAQP4

GO:0006833

water transport

8601457|19383790

TgeneAQP4

GO:0051289

protein homotetramerization

19383790

TgeneAQP4

GO:0071346

cellular response to interferon-gamma

17645239


check buttonFusion gene breakpoints across CHST9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across AQP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BH-A0DG-11ACHST9chr18

24524292

-AQP4chr18

24442560

-
ChimerDB4Non-CancerTCGA-BH-A18U-11ACHST9chr18

24604080

-AQP4chr18

24442560

-
ChimerDB4Non-CancerTCGA-91-6828-11ACHST9chr18

24604080

-AQP4chr18

24442560

-


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Fusion Gene ORF analysis for CHST9-AQP4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000284224ENST00000383168CHST9chr18

24524292

-AQP4chr18

24442560

-
5CDS-5UTRENST00000284224ENST00000581374CHST9chr18

24524292

-AQP4chr18

24442560

-
5CDS-5UTRENST00000284224ENST00000440832CHST9chr18

24524292

-AQP4chr18

24442560

-
5CDS-intronENST00000284224ENST00000583022CHST9chr18

24524292

-AQP4chr18

24442560

-
Frame-shiftENST00000581714ENST00000383168CHST9chr18

24524292

-AQP4chr18

24442560

-
5CDS-5UTRENST00000581714ENST00000581374CHST9chr18

24524292

-AQP4chr18

24442560

-
5CDS-5UTRENST00000581714ENST00000440832CHST9chr18

24524292

-AQP4chr18

24442560

-
5CDS-intronENST00000581714ENST00000583022CHST9chr18

24524292

-AQP4chr18

24442560

-
intron-3CDSENST00000580774ENST00000383168CHST9chr18

24524292

-AQP4chr18

24442560

-
intron-5UTRENST00000580774ENST00000581374CHST9chr18

24524292

-AQP4chr18

24442560

-
intron-5UTRENST00000580774ENST00000440832CHST9chr18

24524292

-AQP4chr18

24442560

-
intron-intronENST00000580774ENST00000583022CHST9chr18

24524292

-AQP4chr18

24442560

-
In-frameENST00000284224ENST00000383168CHST9chr18

24604080

-AQP4chr18

24442560

-
5CDS-5UTRENST00000284224ENST00000581374CHST9chr18

24604080

-AQP4chr18

24442560

-
5CDS-5UTRENST00000284224ENST00000440832CHST9chr18

24604080

-AQP4chr18

24442560

-
5CDS-intronENST00000284224ENST00000583022CHST9chr18

24604080

-AQP4chr18

24442560

-
Frame-shiftENST00000581714ENST00000383168CHST9chr18

24604080

-AQP4chr18

24442560

-
5CDS-5UTRENST00000581714ENST00000581374CHST9chr18

24604080

-AQP4chr18

24442560

-
5CDS-5UTRENST00000581714ENST00000440832CHST9chr18

24604080

-AQP4chr18

24442560

-
5CDS-intronENST00000581714ENST00000583022CHST9chr18

24604080

-AQP4chr18

24442560

-
In-frameENST00000580774ENST00000383168CHST9chr18

24604080

-AQP4chr18

24442560

-
5CDS-5UTRENST00000580774ENST00000581374CHST9chr18

24604080

-AQP4chr18

24442560

-
5CDS-5UTRENST00000580774ENST00000440832CHST9chr18

24604080

-AQP4chr18

24442560

-
5CDS-intronENST00000580774ENST00000583022CHST9chr18

24604080

-AQP4chr18

24442560

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000284224CHST9chr1824604080-ENST00000383168AQP4chr1824442560-55934804391419326
ENST00000580774CHST9chr1824604080-ENST00000383168AQP4chr1824442560-55744614201400326

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000284224ENST00000383168CHST9chr1824604080-AQP4chr1824442560-0.0003312410.9996687
ENST00000580774ENST00000383168CHST9chr1824604080-AQP4chr1824442560-0.0003329840.99966705

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Fusion Genomic Features for CHST9-AQP4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHST9-AQP4


check button Go to

FGviewer for the breakpoints of chr18:24604080-chr18:24442560

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHST9

Q7L1S5

AQP4

P55087

FUNCTION: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.FUNCTION: Forms a water-specific channel (PubMed:7559426, PubMed:8601457, PubMed:19383790). Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity). {ECO:0000250|UniProtKB:P55088, ECO:0000269|PubMed:19383790, ECO:0000269|PubMed:7559426, ECO:0000269|PubMed:8601457}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHST9chr18:24604080chr18:24442560ENST00000284224-461_1267.33333333333333444.0Topological domainCytoplasmic
HgeneCHST9chr18:24604080chr18:24442560ENST00000580774-451_1267.3333333333333375.0Topological domainCytoplasmic
HgeneCHST9chr18:24604080chr18:24442560ENST00000581714-351_1267.33333333333333444.0Topological domainCytoplasmic
HgeneCHST9chr18:24604080chr18:24442560ENST00000284224-4613_3367.33333333333333444.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCHST9chr18:24604080chr18:24442560ENST00000580774-4513_3367.3333333333333375.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCHST9chr18:24604080chr18:24442560ENST00000581714-3513_3367.33333333333333444.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneAQP4chr18:24604080chr18:24442560ENST0000038316805209_22210.666666666666666324.0IntramembraneDiscontinuously helical
TgeneAQP4chr18:24604080chr18:24442560ENST000003831680594_10110.666666666666666324.0IntramembraneDiscontinuously helical
TgeneAQP4chr18:24604080chr18:24442560ENST0000044083205209_2220302.0IntramembraneDiscontinuously helical
TgeneAQP4chr18:24604080chr18:24442560ENST000004408320594_1010302.0IntramembraneDiscontinuously helical
TgeneAQP4chr18:24604080chr18:24442560ENST0000058137404209_2220302.0IntramembraneDiscontinuously helical
TgeneAQP4chr18:24604080chr18:24442560ENST000005813740494_1010302.0IntramembraneDiscontinuously helical
TgeneAQP4chr18:24604080chr18:24442560ENST0000038316805213_21510.666666666666666324.0MotifNPA 2
TgeneAQP4chr18:24604080chr18:24442560ENST000003831680597_9910.666666666666666324.0MotifNPA 1
TgeneAQP4chr18:24604080chr18:24442560ENST0000044083205213_2150302.0MotifNPA 2
TgeneAQP4chr18:24604080chr18:24442560ENST000004408320597_990302.0MotifNPA 1
TgeneAQP4chr18:24604080chr18:24442560ENST0000058137404213_2150302.0MotifNPA 2
TgeneAQP4chr18:24604080chr18:24442560ENST000005813740497_990302.0MotifNPA 1
TgeneAQP4chr18:24604080chr18:24442560ENST0000038316805102_11510.666666666666666324.0Topological domainCytoplasmic
TgeneAQP4chr18:24604080chr18:24442560ENST0000038316805137_15510.666666666666666324.0Topological domainExtracellular
TgeneAQP4chr18:24604080chr18:24442560ENST0000038316805177_18410.666666666666666324.0Topological domainCytoplasmic
TgeneAQP4chr18:24604080chr18:24442560ENST0000038316805206_20810.666666666666666324.0Topological domainExtracellular
TgeneAQP4chr18:24604080chr18:24442560ENST0000038316805223_23110.666666666666666324.0Topological domainExtracellular
TgeneAQP4chr18:24604080chr18:24442560ENST0000038316805253_32310.666666666666666324.0Topological domainCytoplasmic
TgeneAQP4chr18:24604080chr18:24442560ENST000003831680558_6910.666666666666666324.0Topological domainExtracellular
TgeneAQP4chr18:24604080chr18:24442560ENST000003831680590_9310.666666666666666324.0Topological domainCytoplasmic
TgeneAQP4chr18:24604080chr18:24442560ENST0000044083205102_1150302.0Topological domainCytoplasmic
TgeneAQP4chr18:24604080chr18:24442560ENST0000044083205137_1550302.0Topological domainExtracellular
TgeneAQP4chr18:24604080chr18:24442560ENST0000044083205177_1840302.0Topological domainCytoplasmic
TgeneAQP4chr18:24604080chr18:24442560ENST00000440832051_360302.0Topological domainCytoplasmic
TgeneAQP4chr18:24604080chr18:24442560ENST0000044083205206_2080302.0Topological domainExtracellular
TgeneAQP4chr18:24604080chr18:24442560ENST0000044083205223_2310302.0Topological domainExtracellular
TgeneAQP4chr18:24604080chr18:24442560ENST0000044083205253_3230302.0Topological domainCytoplasmic
TgeneAQP4chr18:24604080chr18:24442560ENST000004408320558_690302.0Topological domainExtracellular
TgeneAQP4chr18:24604080chr18:24442560ENST000004408320590_930302.0Topological domainCytoplasmic
TgeneAQP4chr18:24604080chr18:24442560ENST0000058137404102_1150302.0Topological domainCytoplasmic
TgeneAQP4chr18:24604080chr18:24442560ENST0000058137404137_1550302.0Topological domainExtracellular
TgeneAQP4chr18:24604080chr18:24442560ENST0000058137404177_1840302.0Topological domainCytoplasmic
TgeneAQP4chr18:24604080chr18:24442560ENST00000581374041_360302.0Topological domainCytoplasmic
TgeneAQP4chr18:24604080chr18:24442560ENST0000058137404206_2080302.0Topological domainExtracellular
TgeneAQP4chr18:24604080chr18:24442560ENST0000058137404223_2310302.0Topological domainExtracellular
TgeneAQP4chr18:24604080chr18:24442560ENST0000058137404253_3230302.0Topological domainCytoplasmic
TgeneAQP4chr18:24604080chr18:24442560ENST000005813740458_690302.0Topological domainExtracellular
TgeneAQP4chr18:24604080chr18:24442560ENST000005813740490_930302.0Topological domainCytoplasmic
TgeneAQP4chr18:24604080chr18:24442560ENST0000038316805116_13610.666666666666666324.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST0000038316805156_17610.666666666666666324.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST0000038316805185_20510.666666666666666324.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST0000038316805232_25210.666666666666666324.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST000003831680537_5710.666666666666666324.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST000003831680570_8910.666666666666666324.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST0000044083205116_1360302.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST0000044083205156_1760302.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST0000044083205185_2050302.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST0000044083205232_2520302.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST000004408320537_570302.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST000004408320570_890302.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST0000058137404116_1360302.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST0000058137404156_1760302.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST0000058137404185_2050302.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST0000058137404232_2520302.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST000005813740437_570302.0TransmembraneHelical
TgeneAQP4chr18:24604080chr18:24442560ENST000005813740470_890302.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHST9chr18:24604080chr18:24442560ENST00000284224-46220_22667.33333333333333444.0Nucleotide bindingPAPS
HgeneCHST9chr18:24604080chr18:24442560ENST00000284224-46280_28867.33333333333333444.0Nucleotide bindingPAPS
HgeneCHST9chr18:24604080chr18:24442560ENST00000580774-45220_22667.3333333333333375.0Nucleotide bindingPAPS
HgeneCHST9chr18:24604080chr18:24442560ENST00000580774-45280_28867.3333333333333375.0Nucleotide bindingPAPS
HgeneCHST9chr18:24604080chr18:24442560ENST00000581714-35220_22667.33333333333333444.0Nucleotide bindingPAPS
HgeneCHST9chr18:24604080chr18:24442560ENST00000581714-35280_28867.33333333333333444.0Nucleotide bindingPAPS
HgeneCHST9chr18:24604080chr18:24442560ENST00000284224-4634_44367.33333333333333444.0Topological domainLumenal
HgeneCHST9chr18:24604080chr18:24442560ENST00000580774-4534_44367.3333333333333375.0Topological domainLumenal
HgeneCHST9chr18:24604080chr18:24442560ENST00000581714-3534_44367.33333333333333444.0Topological domainLumenal
TgeneAQP4chr18:24604080chr18:24442560ENST00000383168051_3610.666666666666666324.0Topological domainCytoplasmic


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Fusion Gene Sequence for CHST9-AQP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000284224_ENST00000383168_TCGA-BH-A18U-11A_CHST9_chr18_24604080_-_AQP4_chr18_24442560_length(transcript)=5593nt_BP=480nt
GTCAGGGCCAGGGTGAGCGCCCGACTCCGAGCTGTCCCCGCTCCCGGCGCGGCGCTCCGCTCTCAGCCACCTCACGGCTGCCAGGAGTGC
GCGGGAGTTTGCCCCGGAGCGCGGGGAAGTTTCCTCCGAAGCTGCGCTCCTGGAACAGCAGCACCTGCAAGCGCCCGGCAGCGGCCCGCG
AGGTTACTTTATGGAATTGGGCTCTTAGAGAACAAGAAAAGACTGAAGTTTTACGGGAAAACAAATCATGTGGTCTTCAGATTCTGAAAT
AAGGAGAAATGCAGCCATCTGAAATGGTCATGAACCCCAAACAAGTCTTCCTCTCTGTGCTGATATTTGGAGTAGCTGGGCTACTCCTCT
TCATGTATTTGCAAGTCTGGATTGAAGAACAACATACAGGGAGAGTGGAGAAGAGAAGAGAACAAAAAGTAACTTCAGGATGGGGACCAG
TGAAGTACTTGCGGCCTGTACCCAGAATCATAAGTGTGGACCTTTGTGTACCAGAGAGAACATCATGGTGGCTTTCAAAGGGGTCTGGAC
TCAAGCTTTCTGGAAAGCAGTCACAGCGGAATTTCTGGCCATGCTTATTTTTGTTCTCCTCAGCCTGGGATCCACCATCAACTGGGGTGG
AACAGAAAAGCCTTTACCGGTCGACATGGTTCTCATCTCCCTTTGCTTTGGACTCAGCATTGCAACCATGGTGCAGTGCTTTGGCCATAT
CAGCGGTGGCCACATCAACCCTGCAGTGACTGTGGCCATGGTGTGCACCAGGAAGATCAGCATCGCCAAGTCTGTCTTCTACATCGCAGC
CCAGTGCCTGGGGGCCATCATTGGAGCAGGAATCCTCTATCTGGTCACACCTCCCAGTGTGGTGGGAGGCCTGGGAGTCACCATGGTTCA
TGGAAATCTTACCGCTGGTCATGGTCTCCTGGTTGAGTTGATAATCACATTTCAATTGGTGTTTACTATCTTTGCCAGCTGTGATTCCAA
ACGGACTGATGTCACTGGCTCAATAGCTTTAGCAATTGGATTTTCTGTTGCAATTGGACATTTATTTGCAATCAATTATACTGGTGCCAG
CATGAATCCCGCCCGATCCTTTGGACCTGCAGTTATCATGGGAAATTGGGAAAACCATTGGATATATTGGGTTGGGCCCATCATAGGAGC
TGTCCTCGCTGGTGGCCTTTATGAGTATGTCTTCTGTCCAGATGTTGAATTCAAACGTCGTTTTAAAGAAGCCTTCAGCAAAGCTGCCCA
GCAAACAAAAGGAAGCTACATGGAGGTGGAGGACAACAGGAGTCAGGTAGAGACGGATGACCTGATTCTAAAACCTGGAGTGGTGCATGT
GATTGACGTTGACCGGGGAGAGGAGAAGAAGGGGAAAGACCAATCTGGAGAGGTATTGTCTTCAGTATGACTAGAAGATCGCACTGAAAG
CAGACAAGACTCCTTAGAACTGTCCTCAGATTTCCTTCCACCCATTAAGGAAACAGATTTGTTATAAATTAGAAATGTGCAGGTTTGTTG
TTTCATGTCATATTACTCAGTCTAAACAATAAATATTTCATAATTTACAAAGGAGGAACGGAAGAAACCTATTGTGAATTCCAAATCTAA
AAAAAGAAATATTTTTAAAATGTTCTTAAGCAAATATATACCTATTTTATCTAGTTACCTTTCATTAACAACCAATTTTAACCGTGTGTC
AAGATTTGGTTAAGTCTTGCCTGACAGAACTCAAAGACACGTCTATCAGCTTATTCCTTCTCTACTGGAATATTGGTATAGTCAATTCTT
ATTTGAATATTTATTCTATTAAACTGAGTTTAACAATGGCAAAATACAGTATGTCACAGTCATGCACATTCAAGAGAGAAAATATAACAA
GTTCTTTTATGAGCAATCCCTTATGCATAGACTACCTTGGCAAAAGAGCATTAGCAAGTGTCACTGCTCATCAGTTACTTCCTTCCATTT
ATATCACAAATACCCAAGTTTCAATTCTAACTTCATTTCATGGTATTTCTTCCTCCTCAATGCCCAAGGTAATGTGGGACTAAAGCCCAG
AAATTTGAAAAGAATATTCAGAAATCCTTCCCAAATCATAAGGGCACCTATTGAGATTCAAGACAAGCAGACTCGTAAAATCTTGTAGAG
GCAGAGGCAAAGTTATCATCATACAAAAATCACAAACAAAAAGGAGATCTGTATTCGGGTATCAAACGGTTGATCTGTTTTCAGTGCACA
CCCTCAAATGCACCACACCAGTTTTACGATCTAAGCTTTTAACCCCTTTACCACTTTGCTTATTTTTAAAAAATTTATTGGCAAAACTGG
GGATTTTGTTTGTAACTTTGGTTATCTATATTTAAACATTAGCTGAGACATATTTTTGATAACAAGAACTTAGCTAGTTGAGTCCTGGCT
TTTTGTTGATTATTAAGCTGTGTTCACTCTAGAAGGTGTAAAGGCCCTGTCCCAATCTCTGCTCTCTCACTTCTCGTGACATTTGTTGAT
AATCTTTACTGCAAGTGTAATGATATTTGAGTGAATTAAAATGCATGACAGACAAGGTACAACATGGTTGCAGAATAAAAGGGTGAGGAC
ATCAGATCACTCTGTATTCAAAGCTTACTAGACGAACAATCTTTCATTTCTGGATATATTGTAGCTAACCCAACACATTTTTAAACTATT
TTTGTTACTGACTCACTTACTTGTCAAAATAATTGGTTTTTCTGTCCTGCTTTGCCTTTTGTCACTAGAATGTTCTCCAGAAACCCCAGT
TTCTGTCATCTTAACTGTCTAGTCTAGCCGTTAACTTAGACAAAGAAGTGCAAATGTCAATTTCACTAAACAAAAGCTATTAGAAGTAAA
GCAGAAACCTATCACTGCAAGGAGTGACTTGTAAATAACTGATGATCAAGGGCTGTCTTCTCTCAAGCATGGTTCCAACTCTGTGTCACT
TTTTAGCGTTAATGGCAGTTGTGTGTCTGTGGCAGTGAGATAATGGACCACTATTAAACCTGATTCTCTTCGGTGCTAGGAAAGAGTGAT
GTGTGAGATTCCCAGAGAGTCGTCACACCAGTGTTATGCCTGGGAGTGCCACTGGCATACCGCAGGTGCCTAAATCCCAGGCCCCTTTCT
CAGGGGGCGTGGCCACACCACACACTGCGCCAGTGACACATAGTTACTTCCTGGCTGGGACGGCACCTATAGAAACTAGGGTACAAATCT
CCCAAAGATGGTTTGCACCGTCATTTCAAATGTTTGCACAATATACCACTTAGAGGCTTAAAATCAGGGTGGTTCAGTTCAAAAGGTAAT
ATCAACCGTCAGCAAACATGTCAGTTTAAAAATAAGTTCGGTTAACAAGGAAGTGTTAAGCAGATTTTTTGAATACACTTACAATATACT
GGCTTATAATCATTTTTATTCTGCCATATGGTTTATTTCATATACACTCACTTTTACACTCACTTCCAATTATAGCATTCAATAAGTTAC
GGTTAAAGAAAAGTGAATGGTGTTTTTGTAATTTGTTTTCTAGTAGCTAGCAGAGAGCCTGGCACATAGTATGTATTCAAAACAAGTGTG
TTAATTAATAAAAATATATAAATCTCATTTGAGATTTAAGAATATAAATAATTTTCTTTTAATCTTTATTTTGCTCAATATTTAATAGGA
AGTATGATTTCAAGGACTACTAAAGGAAGGCAATATACATGTGAAAACCATAAAATACATTTTTTGCATTCTACTATTTTTAGGGGCATG
AAATGAATGAAAGCTTTAGCACTTTTTTGCCCCTACATATGAGACAACATATTTTGTATTTCACTCAAGGCTCTGCCAGTAAAAAGTAAT
GAAATTGTACCTTTCTAATGACATCTATGCAGCAGGGGTCTATCGCCTTGTGGATGGCACCAAATTATCCAAGTGTATTAGGAGACTGGG
GCTTTTTTCTTTAATCCCTTCTTATTAATGAAGTGCATAGTGCTGCTCCCAGGAGACCACTGCTGACAGATACACAGAGAAGAGATCAGA
GAGGAAAAACTGGGAAGACATAAATGAATTATACCCAGCCATGAAACAATGCCAACTGTCTCTTCCCTAAGGAAGAGTACAAGTACCCTA
AAATTGAAAGGTGGTCCCTACACTGAAAACGCACATAGTTTGTCAAAAGTGTACAAAAGGGAAAGAGTCTTATTTTAAGCTTTCAGGCTT
TCTTAAAAACTTGGGGACCAGAATTTCAATGTATGTTTCCATTGTTGAAGATAACATTTTCTTCAAAGAGCCTTAACCTTTTGTACTGGA
AGGAAATATTTTCTGGACTTAAGTAGTTGCCTAAATTTAAGATTCCTACACTTTATTTCTGCCATTGATGCTTTTCCTAAACCCTTATAC
TATCTTTTTATTATCTGAGCCTTTTCCTAATGCAGCTCATAGGTGCTAGCTAGAGCTGCTGCTCAGTATTGAAGACTTTACAAGGAGATT
AGAAATCTTTGGAAAACATATGTGATGAAATTGAGCTATATGATTTATCAGAGATCTGATTCCAAAGAGCACAGAATACTGTTCTCAGAC
CATGAAACCAGACAACACATGTATTGGTTTAAACTCGATAATGACAGGAAAATTCCAAACTAGAGCAGTAAATTCAAATGGTAAGATGAA
TCCTAGAAGGCCTCTGATTGCAGCATGTTGACACCAACCTCACGTTACGAACAATTCACAGAGAATTTGCCTTTGTGGCAACTGAAGATG
GAAGTCTGGGGGGCACAGACAACCTTATCAAACAATATAAAAGCCAATATAAATTCTCATAAGCACTATAGAATTTGCAAATTCAGAACA
TTTTATACCTAAAAGTAATTCTGTCTTTCCTAAAGTGTTTTTAACATGAAAATTAGTAGGAAGATGTGGTTACTATTTGGAAAGTGTAAT
GTAACAAAACTCTCTTTTGTTACCACAAATTTTGTGAGTTTAGTACTCTACAGATTGCCCCATAAGAGCAGTAGCTTTTGAAACTCATAA
TTCTCTGAAATAAATGAAAGACATTTAATTCAAGGATCAAAAATTGTGGCCATCTTTGCAAATGACTACCTATAGCCTGTGAAAATACAT
TTCAAAAAATGTTATGTGCAATGAACACTAAATTTAAGAGCAGTTACAGTGTGACTCACTCATGTTTAAAAAAAATCGAAGAGCTAAAAA
ATACGTCTAATTTATGTAACCCATTGGAATGTATTTCTAGGTTCTCTTCAGGATTAATTAAATAAACATGCAATTTATGAAAACATATAA
ACAATTATTTATCACTTTTATGACCCAAATCACAATAAAATTGTCATTTAGGATAAACTGGGGAGAATAGACTGAACATATGGTTATATT
CACAGTTATTTATTAACTTAAATGTTATTCCAACATTAGAGCTAATGTTAAAAAGATTTAAACTGTAACGTCTAATATTTGGAATAATAT
ATTAAAGTATTAGCACTGTGGTTGATTTTCTTGAATTATGTTGCATCTTGTACTACTAAGCTTGTGAAAATAAACATTTGGATGTTTTAA

>In-frame_ENST00000284224_ENST00000383168_TCGA-BH-A18U-11A_CHST9_chr18_24604080_-_AQP4_chr18_24442560_length(amino acids)=326AA_start in transcript=439_stop in transcript=1419
MGTSEVLAACTQNHKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQC
FGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFAS
CDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFS

--------------------------------------------------------------
>In-frame_ENST00000580774_ENST00000383168_TCGA-BH-A18U-11A_CHST9_chr18_24604080_-_AQP4_chr18_24442560_length(transcript)=5574nt_BP=461nt
CCCGACTCCGAGCTGTCCCCGCTCCCGGCGCGGCGCTCCGCTCTCAGCCACCTCACGGCTGCCAGGAGTGCGCGGGAGTTTGCCCCGGAG
CGCGGGGAAGTTTCCTCCGAAGCTGCGCTCCTGGAACAGCAGCACCTGCAAGCGCCCGGCAGCGGCCCGCGAGGTTACTTTATGGAATTG
GGCTCTTAGAGAACAAGAAAAGACTGAAGTTTTACGGGAAAACAAATCATGTGGTCTTCAGATTCTGAAATAAGGAGAAATGCAGCCATC
TGAAATGGTCATGAACCCCAAACAAGTCTTCCTCTCTGTGCTGATATTTGGAGTAGCTGGGCTACTCCTCTTCATGTATTTGCAAGTCTG
GATTGAAGAACAACATACAGGGAGAGTGGAGAAGAGAAGAGAACAAAAAGTAACTTCAGGATGGGGACCAGTGAAGTACTTGCGGCCTGT
ACCCAGAATCATAAGTGTGGACCTTTGTGTACCAGAGAGAACATCATGGTGGCTTTCAAAGGGGTCTGGACTCAAGCTTTCTGGAAAGCA
GTCACAGCGGAATTTCTGGCCATGCTTATTTTTGTTCTCCTCAGCCTGGGATCCACCATCAACTGGGGTGGAACAGAAAAGCCTTTACCG
GTCGACATGGTTCTCATCTCCCTTTGCTTTGGACTCAGCATTGCAACCATGGTGCAGTGCTTTGGCCATATCAGCGGTGGCCACATCAAC
CCTGCAGTGACTGTGGCCATGGTGTGCACCAGGAAGATCAGCATCGCCAAGTCTGTCTTCTACATCGCAGCCCAGTGCCTGGGGGCCATC
ATTGGAGCAGGAATCCTCTATCTGGTCACACCTCCCAGTGTGGTGGGAGGCCTGGGAGTCACCATGGTTCATGGAAATCTTACCGCTGGT
CATGGTCTCCTGGTTGAGTTGATAATCACATTTCAATTGGTGTTTACTATCTTTGCCAGCTGTGATTCCAAACGGACTGATGTCACTGGC
TCAATAGCTTTAGCAATTGGATTTTCTGTTGCAATTGGACATTTATTTGCAATCAATTATACTGGTGCCAGCATGAATCCCGCCCGATCC
TTTGGACCTGCAGTTATCATGGGAAATTGGGAAAACCATTGGATATATTGGGTTGGGCCCATCATAGGAGCTGTCCTCGCTGGTGGCCTT
TATGAGTATGTCTTCTGTCCAGATGTTGAATTCAAACGTCGTTTTAAAGAAGCCTTCAGCAAAGCTGCCCAGCAAACAAAAGGAAGCTAC
ATGGAGGTGGAGGACAACAGGAGTCAGGTAGAGACGGATGACCTGATTCTAAAACCTGGAGTGGTGCATGTGATTGACGTTGACCGGGGA
GAGGAGAAGAAGGGGAAAGACCAATCTGGAGAGGTATTGTCTTCAGTATGACTAGAAGATCGCACTGAAAGCAGACAAGACTCCTTAGAA
CTGTCCTCAGATTTCCTTCCACCCATTAAGGAAACAGATTTGTTATAAATTAGAAATGTGCAGGTTTGTTGTTTCATGTCATATTACTCA
GTCTAAACAATAAATATTTCATAATTTACAAAGGAGGAACGGAAGAAACCTATTGTGAATTCCAAATCTAAAAAAAGAAATATTTTTAAA
ATGTTCTTAAGCAAATATATACCTATTTTATCTAGTTACCTTTCATTAACAACCAATTTTAACCGTGTGTCAAGATTTGGTTAAGTCTTG
CCTGACAGAACTCAAAGACACGTCTATCAGCTTATTCCTTCTCTACTGGAATATTGGTATAGTCAATTCTTATTTGAATATTTATTCTAT
TAAACTGAGTTTAACAATGGCAAAATACAGTATGTCACAGTCATGCACATTCAAGAGAGAAAATATAACAAGTTCTTTTATGAGCAATCC
CTTATGCATAGACTACCTTGGCAAAAGAGCATTAGCAAGTGTCACTGCTCATCAGTTACTTCCTTCCATTTATATCACAAATACCCAAGT
TTCAATTCTAACTTCATTTCATGGTATTTCTTCCTCCTCAATGCCCAAGGTAATGTGGGACTAAAGCCCAGAAATTTGAAAAGAATATTC
AGAAATCCTTCCCAAATCATAAGGGCACCTATTGAGATTCAAGACAAGCAGACTCGTAAAATCTTGTAGAGGCAGAGGCAAAGTTATCAT
CATACAAAAATCACAAACAAAAAGGAGATCTGTATTCGGGTATCAAACGGTTGATCTGTTTTCAGTGCACACCCTCAAATGCACCACACC
AGTTTTACGATCTAAGCTTTTAACCCCTTTACCACTTTGCTTATTTTTAAAAAATTTATTGGCAAAACTGGGGATTTTGTTTGTAACTTT
GGTTATCTATATTTAAACATTAGCTGAGACATATTTTTGATAACAAGAACTTAGCTAGTTGAGTCCTGGCTTTTTGTTGATTATTAAGCT
GTGTTCACTCTAGAAGGTGTAAAGGCCCTGTCCCAATCTCTGCTCTCTCACTTCTCGTGACATTTGTTGATAATCTTTACTGCAAGTGTA
ATGATATTTGAGTGAATTAAAATGCATGACAGACAAGGTACAACATGGTTGCAGAATAAAAGGGTGAGGACATCAGATCACTCTGTATTC
AAAGCTTACTAGACGAACAATCTTTCATTTCTGGATATATTGTAGCTAACCCAACACATTTTTAAACTATTTTTGTTACTGACTCACTTA
CTTGTCAAAATAATTGGTTTTTCTGTCCTGCTTTGCCTTTTGTCACTAGAATGTTCTCCAGAAACCCCAGTTTCTGTCATCTTAACTGTC
TAGTCTAGCCGTTAACTTAGACAAAGAAGTGCAAATGTCAATTTCACTAAACAAAAGCTATTAGAAGTAAAGCAGAAACCTATCACTGCA
AGGAGTGACTTGTAAATAACTGATGATCAAGGGCTGTCTTCTCTCAAGCATGGTTCCAACTCTGTGTCACTTTTTAGCGTTAATGGCAGT
TGTGTGTCTGTGGCAGTGAGATAATGGACCACTATTAAACCTGATTCTCTTCGGTGCTAGGAAAGAGTGATGTGTGAGATTCCCAGAGAG
TCGTCACACCAGTGTTATGCCTGGGAGTGCCACTGGCATACCGCAGGTGCCTAAATCCCAGGCCCCTTTCTCAGGGGGCGTGGCCACACC
ACACACTGCGCCAGTGACACATAGTTACTTCCTGGCTGGGACGGCACCTATAGAAACTAGGGTACAAATCTCCCAAAGATGGTTTGCACC
GTCATTTCAAATGTTTGCACAATATACCACTTAGAGGCTTAAAATCAGGGTGGTTCAGTTCAAAAGGTAATATCAACCGTCAGCAAACAT
GTCAGTTTAAAAATAAGTTCGGTTAACAAGGAAGTGTTAAGCAGATTTTTTGAATACACTTACAATATACTGGCTTATAATCATTTTTAT
TCTGCCATATGGTTTATTTCATATACACTCACTTTTACACTCACTTCCAATTATAGCATTCAATAAGTTACGGTTAAAGAAAAGTGAATG
GTGTTTTTGTAATTTGTTTTCTAGTAGCTAGCAGAGAGCCTGGCACATAGTATGTATTCAAAACAAGTGTGTTAATTAATAAAAATATAT
AAATCTCATTTGAGATTTAAGAATATAAATAATTTTCTTTTAATCTTTATTTTGCTCAATATTTAATAGGAAGTATGATTTCAAGGACTA
CTAAAGGAAGGCAATATACATGTGAAAACCATAAAATACATTTTTTGCATTCTACTATTTTTAGGGGCATGAAATGAATGAAAGCTTTAG
CACTTTTTTGCCCCTACATATGAGACAACATATTTTGTATTTCACTCAAGGCTCTGCCAGTAAAAAGTAATGAAATTGTACCTTTCTAAT
GACATCTATGCAGCAGGGGTCTATCGCCTTGTGGATGGCACCAAATTATCCAAGTGTATTAGGAGACTGGGGCTTTTTTCTTTAATCCCT
TCTTATTAATGAAGTGCATAGTGCTGCTCCCAGGAGACCACTGCTGACAGATACACAGAGAAGAGATCAGAGAGGAAAAACTGGGAAGAC
ATAAATGAATTATACCCAGCCATGAAACAATGCCAACTGTCTCTTCCCTAAGGAAGAGTACAAGTACCCTAAAATTGAAAGGTGGTCCCT
ACACTGAAAACGCACATAGTTTGTCAAAAGTGTACAAAAGGGAAAGAGTCTTATTTTAAGCTTTCAGGCTTTCTTAAAAACTTGGGGACC
AGAATTTCAATGTATGTTTCCATTGTTGAAGATAACATTTTCTTCAAAGAGCCTTAACCTTTTGTACTGGAAGGAAATATTTTCTGGACT
TAAGTAGTTGCCTAAATTTAAGATTCCTACACTTTATTTCTGCCATTGATGCTTTTCCTAAACCCTTATACTATCTTTTTATTATCTGAG
CCTTTTCCTAATGCAGCTCATAGGTGCTAGCTAGAGCTGCTGCTCAGTATTGAAGACTTTACAAGGAGATTAGAAATCTTTGGAAAACAT
ATGTGATGAAATTGAGCTATATGATTTATCAGAGATCTGATTCCAAAGAGCACAGAATACTGTTCTCAGACCATGAAACCAGACAACACA
TGTATTGGTTTAAACTCGATAATGACAGGAAAATTCCAAACTAGAGCAGTAAATTCAAATGGTAAGATGAATCCTAGAAGGCCTCTGATT
GCAGCATGTTGACACCAACCTCACGTTACGAACAATTCACAGAGAATTTGCCTTTGTGGCAACTGAAGATGGAAGTCTGGGGGGCACAGA
CAACCTTATCAAACAATATAAAAGCCAATATAAATTCTCATAAGCACTATAGAATTTGCAAATTCAGAACATTTTATACCTAAAAGTAAT
TCTGTCTTTCCTAAAGTGTTTTTAACATGAAAATTAGTAGGAAGATGTGGTTACTATTTGGAAAGTGTAATGTAACAAAACTCTCTTTTG
TTACCACAAATTTTGTGAGTTTAGTACTCTACAGATTGCCCCATAAGAGCAGTAGCTTTTGAAACTCATAATTCTCTGAAATAAATGAAA
GACATTTAATTCAAGGATCAAAAATTGTGGCCATCTTTGCAAATGACTACCTATAGCCTGTGAAAATACATTTCAAAAAATGTTATGTGC
AATGAACACTAAATTTAAGAGCAGTTACAGTGTGACTCACTCATGTTTAAAAAAAATCGAAGAGCTAAAAAATACGTCTAATTTATGTAA
CCCATTGGAATGTATTTCTAGGTTCTCTTCAGGATTAATTAAATAAACATGCAATTTATGAAAACATATAAACAATTATTTATCACTTTT
ATGACCCAAATCACAATAAAATTGTCATTTAGGATAAACTGGGGAGAATAGACTGAACATATGGTTATATTCACAGTTATTTATTAACTT
AAATGTTATTCCAACATTAGAGCTAATGTTAAAAAGATTTAAACTGTAACGTCTAATATTTGGAATAATATATTAAAGTATTAGCACTGT

>In-frame_ENST00000580774_ENST00000383168_TCGA-BH-A18U-11A_CHST9_chr18_24604080_-_AQP4_chr18_24442560_length(amino acids)=326AA_start in transcript=420_stop in transcript=1400
MGTSEVLAACTQNHKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQC
FGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFAS
CDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHST9-AQP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHST9-AQP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHST9-AQP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAQP4C0011570Mental Depression2PSYGENET
TgeneAQP4C0027873Neuromyelitis Optica2CTD_human
TgeneAQP4C0036341Schizophrenia2PSYGENET
TgeneAQP4C0338715Drug-induced depressive state2PSYGENET
TgeneAQP4C0004352Autistic Disorder1CTD_human
TgeneAQP4C0011581Depressive disorder1PSYGENET
TgeneAQP4C0038220Status Epilepticus1CTD_human
TgeneAQP4C0038644Sudden infant death syndrome1GENOMICS_ENGLAND
TgeneAQP4C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneAQP4C0270823Petit mal status1CTD_human
TgeneAQP4C0311335Grand Mal Status Epilepticus1CTD_human
TgeneAQP4C0393734Complex Partial Status Epilepticus1CTD_human
TgeneAQP4C0751522Status Epilepticus, Subclinical1CTD_human
TgeneAQP4C0751523Non-Convulsive Status Epilepticus1CTD_human
TgeneAQP4C0751524Simple Partial Status Epilepticus1CTD_human