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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CLDN12-SPCS3 (FusionGDB2 ID:17060)

Fusion Gene Summary for CLDN12-SPCS3

check button Fusion gene summary
Fusion gene informationFusion gene name: CLDN12-SPCS3
Fusion gene ID: 17060
HgeneTgene
Gene symbol

CLDN12

SPCS3

Gene ID

9069

60559

Gene nameclaudin 12signal peptidase complex subunit 3
Synonyms-PRO3567|SPC22/23|SPC3|YLR066W
Cytomap

7q21.13

4q34.2

Type of geneprotein-codingprotein-coding
Descriptionclaudin-12signal peptidase complex subunit 3SPase 22 kDa subunitSPase 22/23 kDa subunitmicrosomal signal peptidase 22/23 kDa subunitmicrosomal signal peptidase 23 kDa subunitsignal peptidase complex subunit 3 homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000287916, ENST00000535571, 
ENST00000394605, ENST00000478752, 
ENST00000503362, ENST00000507001, 
Fusion gene scores* DoF score7 X 4 X 6=1684 X 2 X 2=16
# samples 74
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CLDN12 [Title/Abstract] AND SPCS3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLDN12(90045268)-SPCS3(177243321), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSPCS3

GO:0006508

proteolysis

27499293


check buttonFusion gene breakpoints across CLDN12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SPCS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-7783-01ACLDN12chr7

90045268

-SPCS3chr4

177243321

+


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Fusion Gene ORF analysis for CLDN12-SPCS3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000287916ENST00000503362CLDN12chr7

90045268

-SPCS3chr4

177243321

+
5CDS-intronENST00000287916ENST00000507001CLDN12chr7

90045268

-SPCS3chr4

177243321

+
In-frameENST00000535571ENST00000503362CLDN12chr7

90045268

-SPCS3chr4

177243321

+
5CDS-intronENST00000535571ENST00000507001CLDN12chr7

90045268

-SPCS3chr4

177243321

+
In-frameENST00000394605ENST00000503362CLDN12chr7

90045268

-SPCS3chr4

177243321

+
5CDS-intronENST00000394605ENST00000507001CLDN12chr7

90045268

-SPCS3chr4

177243321

+
intron-3CDSENST00000478752ENST00000503362CLDN12chr7

90045268

-SPCS3chr4

177243321

+
intron-intronENST00000478752ENST00000507001CLDN12chr7

90045268

-SPCS3chr4

177243321

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000287916CLDN12chr790045268-ENST00000503362SPCS3chr4177243321+788035652781021247
ENST00000535571CLDN12chr790045268-ENST00000503362SPCS3chr4177243321+790235873001043247
ENST00000394605CLDN12chr790045268-ENST00000503362SPCS3chr4177243321+78033488201944247

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000287916ENST00000503362CLDN12chr790045268-SPCS3chr4177243321+0.0067802950.9932197
ENST00000535571ENST00000503362CLDN12chr790045268-SPCS3chr4177243321+0.00660210.99339783
ENST00000394605ENST00000503362CLDN12chr790045268-SPCS3chr4177243321+0.0067900020.99321

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Fusion Genomic Features for CLDN12-SPCS3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CLDN12-SPCS3


check button Go to

FGviewer for the breakpoints of chr7:90045268-chr4:177243321

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLDN12chr7:90045268chr4:177243321ENST00000287916-33109_1351092.6666666666667245.0Topological domainCytoplasmic
HgeneCLDN12chr7:90045268chr4:177243321ENST00000287916-33157_1741092.6666666666667245.0Topological domainExtracellular
HgeneCLDN12chr7:90045268chr4:177243321ENST00000287916-33196_2441092.6666666666667245.0Topological domainCytoplasmic
HgeneCLDN12chr7:90045268chr4:177243321ENST00000287916-331_101092.6666666666667245.0Topological domainCytoplasmic
HgeneCLDN12chr7:90045268chr4:177243321ENST00000287916-3332_871092.6666666666667245.0Topological domainExtracellular
HgeneCLDN12chr7:90045268chr4:177243321ENST00000394605-33109_1351092.6666666666667245.0Topological domainCytoplasmic
HgeneCLDN12chr7:90045268chr4:177243321ENST00000394605-33157_1741092.6666666666667245.0Topological domainExtracellular
HgeneCLDN12chr7:90045268chr4:177243321ENST00000394605-33196_2441092.6666666666667245.0Topological domainCytoplasmic
HgeneCLDN12chr7:90045268chr4:177243321ENST00000394605-331_101092.6666666666667245.0Topological domainCytoplasmic
HgeneCLDN12chr7:90045268chr4:177243321ENST00000394605-3332_871092.6666666666667245.0Topological domainExtracellular
HgeneCLDN12chr7:90045268chr4:177243321ENST00000535571-22109_1351092.6666666666667245.0Topological domainCytoplasmic
HgeneCLDN12chr7:90045268chr4:177243321ENST00000535571-22157_1741092.6666666666667245.0Topological domainExtracellular
HgeneCLDN12chr7:90045268chr4:177243321ENST00000535571-22196_2441092.6666666666667245.0Topological domainCytoplasmic
HgeneCLDN12chr7:90045268chr4:177243321ENST00000535571-221_101092.6666666666667245.0Topological domainCytoplasmic
HgeneCLDN12chr7:90045268chr4:177243321ENST00000535571-2232_871092.6666666666667245.0Topological domainExtracellular
HgeneCLDN12chr7:90045268chr4:177243321ENST00000287916-3311_311092.6666666666667245.0TransmembraneHelical
HgeneCLDN12chr7:90045268chr4:177243321ENST00000287916-33136_1561092.6666666666667245.0TransmembraneHelical
HgeneCLDN12chr7:90045268chr4:177243321ENST00000287916-33175_1951092.6666666666667245.0TransmembraneHelical
HgeneCLDN12chr7:90045268chr4:177243321ENST00000287916-3388_1081092.6666666666667245.0TransmembraneHelical
HgeneCLDN12chr7:90045268chr4:177243321ENST00000394605-3311_311092.6666666666667245.0TransmembraneHelical
HgeneCLDN12chr7:90045268chr4:177243321ENST00000394605-33136_1561092.6666666666667245.0TransmembraneHelical
HgeneCLDN12chr7:90045268chr4:177243321ENST00000394605-33175_1951092.6666666666667245.0TransmembraneHelical
HgeneCLDN12chr7:90045268chr4:177243321ENST00000394605-3388_1081092.6666666666667245.0TransmembraneHelical
HgeneCLDN12chr7:90045268chr4:177243321ENST00000535571-2211_311092.6666666666667245.0TransmembraneHelical
HgeneCLDN12chr7:90045268chr4:177243321ENST00000535571-22136_1561092.6666666666667245.0TransmembraneHelical
HgeneCLDN12chr7:90045268chr4:177243321ENST00000535571-22175_1951092.6666666666667245.0TransmembraneHelical
HgeneCLDN12chr7:90045268chr4:177243321ENST00000535571-2288_1081092.6666666666667245.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPCS3chr7:90045268chr4:177243321ENST00000503362051_1147.666666666666664181.0Topological domainCytoplasmic
TgeneSPCS3chr7:90045268chr4:177243321ENST000005033620533_18047.666666666666664181.0Topological domainLumenal
TgeneSPCS3chr7:90045268chr4:177243321ENST000005033620512_3247.666666666666664181.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for CLDN12-SPCS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000287916_ENST00000503362_TCGA-EJ-7783-01A_CLDN12_chr7_90045268_-_SPCS3_chr4_177243321_length(transcript)=7880nt_BP=3565nt
GCCATCCAGGGCATTGCCGTTCAGGGCCACGGGAAAACCTGACTGCGCTCCCAGAAGCCTCCGGTGTACCTCGCTGGGAACGCACTTCCT
GGGACGCTGAGAGGGAGACGCTCCAAGAGGCTCCTCAGTGTGGGCGAGTAAAATGCCCTGCGTGTGAGAAGCAGGCTCAGATTATTGCTA
CTCTGTATTCAGATCTTCATGTGTCTCTTCTAAGCTGAATAAAGCTGTTTTGGAACTGTCAGGTACCTCAAAGCTCTGACTGACAGTACT
CCACAAGCTTGCCTGCCATGGGCTGTCGGGATGTCCACGCAGCCACAGTCCTTTCCTTCCTGTGTGGAATCGCCTCAGTAGCAGGCCTCT
TTGCAGGGACTCTGCTTCCCAACTGGAGAAAATTACGATTGATCACATTCAACAGAAACGAGAAGAACCTGACTGTTTACACAGGCCTGT
GGGTGAAATGTGCCCGGTATGACGGGAGCAGTGACTGCCTGATGTACGACACTACTTGGTACTCATCAGTTGACCAGCTGGACCTGCGTG
TCCTCCAGTTTGCCCTACCCCTCAGCATGCTGATCGCCATGGGTGCCCTGCTGCTCTGCCTGATTGGAATGTGCAACACTGCCTTCAGGT
CCTCGGTGCCCAACATCAAACTGGCCAAGTGTCTGGTCAATAGTGCAGGTTGCCACCTGGTGGCTGGGCTGCTATTTTTCCTGGCAGGTA
CTGTGAGCCTCTCCCCATCTATCTGGGTCATCTTTTATAACATCCATCTGAACAAGAAGTTTGAGCCAGTCTTTTCATTTGACTATGCAG
TGTATGTCACTATTGCTAGTGCTGGGGGCCTGTTTATGACTTCCCTTATACTATTTATTTGGTATTGTACATGCAAATCTTTGCCTTCTC
CTTTCTGGCAACCATTGTACTCCCATCCACCCAGTATGCATACTTACTCACAGCCCTATTCAGCACGCTCTCGCCTCTCTGCCATTGAAA
TTGACATTCCAGTAGTTTCACACACCACTTAATGGGGAAATAGTTAATTGTTAAAGAAAACTTCTTGTAGCCTCACATTCCCCTTGTGCA
AAGAGCTCTTTTGGACCTACATACATTTTCCTTTGTTTTTGACCAATCAATGAAGCCAAATTTATATGTCCTAGTAGAATGAAGTGCTGC
TAGTTTTTATGAGAAGTATATTATATTAAATGTGAATTTTTTAAATTTTGCTTCTTATACTGGAAGGAATTTTAGCCTTCATATTGATAT
CTAATTAATTATTTAAGTGGAAGAGGCCTGCATCACAATTGAGGTAATGTAGAGCAACATGTTAAAGAATGATGGTTAGCAGAAGCTGTT
GTATACAATCTTCATGAAAATTTCAGTGTGTATTTTTCTTTTTCTATAATACCTTTAACTGCAAAGAAAAGGCAGTTTCAAATATAAGAA
ATTTATTTCAGGTAAGGGTAATATTTTAATAGTAGTCAATAATCTAGCTTAAGGCTGTAACTCTTCTATCGGGGCTAATTGTATGAATAG
GTGTCAGTATGTTGAAGATTACTTTCTTTTGTGACTTTCTTCTACCTCATGCCACTGTTTAAAAGTAAAACGTATTTTAACGATGTTAGA
ATAAGACTACCATTCTAAATATCACCTACTTATGAATAACATGTAATAATTTTTAACATTAATGATTCCATAAATTGTATTATTGGGATT
AGAATGTGCTTTATGACAGGTTAGTGTTTCCTCTGAGGCAGAAAACTCTTTTTTGGAGATATCTTCCATCAAGCAGTACTCGTGCCCATA
TACAATCTCTTAGTGGCTAGGAGAAATAAATAAAAGGGCCATAATGGTTTGTTCTCTTTCAGACATAATTTAGTAGGGGACAAGAAGTCT
GTTCTTCAGTGAGTACACTAGAGATTTACTCTGGTGACTGCCTTTTGAGTTATGGGTGAAGTAAGGTATGGCTTTACCATAACCTTGATT
CATTCACCCTTGATTCATTTCTCGCCCCCGTCACTGATTATTTCCTTGAGCATATATCTCTGCCTAACACTTTAGTAGGTGCTATAGAGG
ATACATGAAAAGTATGAGATCTGGTTCCATCCAGTAAGACATTTTAATAGAGAAGATCAAAATGTTACCTGGCAGTTGGGGAATAATCTG
ACTTCGTTGGCAGTTGGCCTTAACTTCTTAATCATTGATCCAGGAATATTTCAACCAGAGACACAACTTTCTGGCAGACAGACAAATTGT
ACAACACCAACAATATCCTGGACCTTGAAATTCTGTTTACTTCAGTCCATTGTATCCTTTAAGGCACCTGTGCTAGCCTAGATTTTGTAA
TAACACTGATTTATGAGAATGGACAAAAGTGGTAGGGAAATTGTTCCCTCTCCACTTCTGAAAGTATGATGATGTATTAAGGATGGAGGA
GTTATTAAAAATGTCTCTTCTGATGAGGTAACAATTAGATGAAACCATGTTAAAGCTGAGATGAACACTTAGAAATTCAGGGATATTGGG
TCTTTAGCCTTATGAATTTGAGCTGCTTATTTAATTGGTGTAATTTACTACATATTAGTACTATATTCGTAAGGATTTTTTATTAACCAT
TACAGATTTTACAAACAGCTAGTTATATGGTAAACAGATTATTATGCCTTTTTGCAATTCTGAATATGATTCTAGTATTTGTGTAGATGT
ATTTGGTACTTTTTCCCCTAATTCCAACACTAGTTTATATATATAGCGAATAAATCTAGTTGTATAAATTTTTAAATGCCGTCAGTAGAA
AGCACACAAGGTTATGATTTTTTTAATTACTGGCTTCTGATTTCTTTCACTTCTGATCCTTTTCCTTTTTCTCAGATGTAGCTGAGTCTT
GATCATTTTAAGACAACGATGGGTAGAATTTTGAGATTAATGTTAATTTTCCCTTTTTGTTAATTTCAGTCCCCTCTCACTATGCTTTTG
TCCAGAAGGATCAAGAATTCTACCATCCCTTGGGTCTTTGTGTATAAACAATGTTAAATAAAGGTAGACTCAGTCTTTAAGATATTAGAC
AGTTTTTTTAGTCCATGGGATTGTAAATATAAACATTAACTTTCCTATAAGAATATTTTGGCTTTGTAATCTATAGCCTCAAATTGGTAT
TTATTATGGATTCACTAGACAAACAGCTGTTTCCTTATTGTCTTTTTTCTTTAGTGTTTCTGATTTGCTATCAGTAGCTGTTTTTAAAGC
CGTCCAAGGAAAATAATTATTTACAGTTTTTGAAGTCACTTTTGAGCCCTCATCAAGCTCTCATTGTGATGGGAGGGATACCTTTTTGTT
GTTAAAAGCCTATTATTGTTAAAGGCCTTTTATGGAAACCAACTTGGAAAACAACCTTAAATGTGGATGTATCAGATTTGGTTTATCCAG
CCATGGGAGAGAAAACAAACCTAAGTTTACTTTACTTGTACATATACACTACAATGGATAGTATATTTGCTGTAAACTACAATGTAAAAC
CTCAATAAAAGTGCGCTGTACTTCTTAATGTTTATTAAAAGATGTATTTTTACAAAAAAAATGTAGAAGATTTCACTGGACCTAGAGAAA
GAAGTGATCTGGGATTTATCACATTTGATATAACTGCTGATCTAGAGAATATATTTGATTGGAATGTTAAGCAGTTGTTTCTTTATTTAT
CAGCAGAATATTCAACAAAAAATAATGCTCTGAACCAAGTTGTCCTATGGGACAAGATTGTTTTGAGAGGTGATAATCCGAAGCTGCTGC
TGAAAGATATGAAAACAAAATATTTTTTCTTTGACGATGGAAATGGTCTCAAGGGAAACAGGAATGTCACTTTGACCCTGTCTTGGAACG
TCGTACCAAATGCTGGAATTCTACCTCTTGTGACAGGATCAGGACACGTATCTGTCCCATTTCCAGATACATATGAAATAACGAAGAGTT
ATTAAATTATTCTGAATTTGAAACAACATATTTTTATACTTAATGAATTGTATCTCATTAATCTCTTCCCTTACATCTTCATGTATTGTT
GGTTTGTTTTTTGGTTTTGGGTTTTTTTTTTTTTTTTTTTGGTATAAGAACTAACATCAAAAGGCCTGTTTAAAGGGAAAGGTTAATGGG
CTACTTAATATTATGAACAAAACAAAAAAACAAGGCTGCCACAGTGGAATATTATCTTACAAGAATAAGAACTACATAAAACAGATTTGT
AAAAAATACATATTTGAAGTATTCCCTGTATTTCCATTATTCTTTATGGAATATAAAGTAAGCATGAAAGGTAGTTAAAACTTTCAGGTG
CCTGTAGAGTCATAATAACTGTATTTTATGCCTTGCATTCACGCAAATTCACATTGGATGTGATTTAAAAGTAGACATTCTCTTTTTCCT
CTTTTAGGATATGTTTGATTACTGGAAAATTAATATGGTTATTTGTTAGAAGTCTGGTTTATAAAAAAGCCAAAAGTGATGGAATTTATT
CCATTTGTCTTAGGAAGGCCCATAATACTTGTTTTTCTTACATGTGACTAGCAACTTTCTCCACTTAAAGACTAAATACCTCTTTATATG
ATGTAAATTATTCTAATTCATTTTAAAATCTTTTAGGTCAGCAAAATGTGTGTCTTCAGTGCTTTCTCTAAAAACGTTCCTTTATAGCTT
TGTACTTTTTTTTTTAGCGTTGCCATTGAAAGTTAAAATGTTTGCATGGTTTACCCTCTGAGTTATGTTTCTTCTAGTGAGCATGCCTGC
TGTCACTAAGTGAATTATTTACTACTTTTTGTAGGTCTATATTTTAATAATTATTGGGATAATAATAATTGTGGTATGCTTTCCATTTAC
AAACCACTCATATACTTTAGTGTATGTCATCCTCAATAATCTAATGAGGTAAGTAGTATAAGTGTTAGCTCTTTGCAGATAAGAAACTGA
AACCCAGAAGTTTATTGAATTGCTTCATTGTTACCTAGCCAGCAAGGAGTGGAATTAAAACTTGAACTCAGATCTTCTAATTTTCTGAGC
TCATCCTTTCTCTTATACCTCAGATTGCAGACTAATCAAATTTTACTTAAAACCTTCCTGATATTTTTGTTACCCTGGACACCCTTTCTA
TTCTAGAAAAGGTTTCCCATTTTATATGGAAGTGACTAATTTTCAAGCTGCCAACAACTTATATCGAGGTAATATTTTATTCTCTGAATA
AATTCATTTCACTTATATTAAAAGCATAAGGAAATCTACATGTATGTAAAAATAACTTAGAAATTCAGTACATAATACATGATTGAATAC
ATGATCGTATTTAACATGTTTTTTTTTTCTGCAGTGGACAAATAAACATCCTCAAAGTAGCAACTGCAAATCAGTTACCCTTAGAAAAGC
AAGACCAAACACTGTAGTTACACTATTAGCAGTGACCAAAAAGGGCTAATATTTTCTAAGAATAGTTTAAATTACAGACATTTGTTATAT
TTACCTTATGTGAAATACATCACTATTTAATTACATTAATTTTAACATCTGTTGTGTGGAGTTGTATAGTTCATGCAAAAGCCTGTGGGT
ATGGGTTTTTCAAACCAGCAGAAAGGTCAAAGGTACCTGAATGCTAAACTGCCTGGCTCCCAGCTTTTTCATTAAACTTTTCAGGGTCTT
GGTTTCTTTATCTGTAAAATGACAGAGTTGGACCAGTTAACTTTAATGGCCATCCTTTTACACCACACAAGTTGATAAAATTTATCTGTT
CAGCAAAGAGATTGAACAAAAAAGCACGTTAGTAATATGAAGACAGGAAAACGAATGAAAGTCTAACACATAACTCATATTGATTTACTT
TATTTCTGTTAGATTTTACACTCTGAAAATTTCACCTCATTTAGTTTGTACAAATACTAGACATGGAAACTTAAAATGTGCAGGTGTCAA
AGCTTAAAAATCAGGTGTGTCCTCTTTAAAGGCATGTGCGATAAGCCTGCAGTCTTAACCAGACCTGGTACCAGTTTAACAGTTCATGAT
ACTTCTGTGATGAGTGGATCTGTTAGTCTGGTAGAGATTAATGTTGAAATTTACTTGAATTACAGTTATTTGACAAGCCCACTTTTTTTG
GAGTTTGGTGAGGAAGATAAGTAAAAATGCCCAACTAGTACAATGTGGAGAAAGTTTTCTGTTTGCTTGACTAAGGGAAATTGCTCAGAA
AAAGAATGCTCCAACATGGGAATAAGGACCTTCAGTCTCAGGAACTCATTTTTGGGTGCAGTTTCTACATTTAAAAAATTGACTTGTGTT
CAGTTTGATAACCAGTTCATTTGCTTTAGTCTCAGTGTTTTAAAGAAGTCTCATAATGTTCTACAAAGACACAAAGCTTCAGGCTTATAC
AAAACTGAGTATGATTAGAAATACCTGAGCCCAGAAATGATTCTGAGAAAAGAGAATAATTTGAAGACACTTATTTAAAAGTAATTATGG
TTAGAAATGAATTAATTTAAAAATGTGTTCACATATCCCTTTCTCTAACAGTTTAACCTAGACAAACATCTGTATCAGTATTTTTTTATT
CCCCTGATTGATTACATTTGGTTTCTTTATTCTGAAAGGAAAATAACAAAAACTTCAGAAATTCCTAAGGGTGTAATAAGAAAGTGGGTT
TTGAGTTTCCTTTCCTGGAATTATTTTACAGTTCTTTGGTGGGTCTCGTCAGCCAATTCATAGCTGGGCTTTAAGATTATCATCTTAGAG
ATGATAGATGGGCTTTTTAAAGATTTCATCTTAGAGATGAAAAGCTGGGCTTTTTCTCTAAGATGATAATCTTAAAGCCCAGCTATTAAT
TGATAATGAACATTTTTCACTATTTTTTTTTCTATCTGAAGCTTAGAGATCTAGAGCTTTGGATCTTTCGGGTATATGTCAATGGAGGTA
TTATTTTATAATACTTTGCATTGACATGAAGTGGGTTCATGGGGGAAAACCATGAGCTGTGAACATTGGTAGCAAACAAGCATATATTCA
TTTCAAAACTTTCCTTGCTTTTAGCAGAGAGAAGCCTGTATATGTTACATGTGTGACTTTCAGTAGTTTAAAGAGATGTTTCAAAAAATT
GTTGCATGTTTTTGATGCAATTTGGGAAATTGTTTACTTCACAATGTAGTCATTCATAAAAAAATTCATGAAAATACTGAACATATGTTT
GAGGATTTTTCTTTTCCTTTTTAAATTTTTTTATTTTTTCTGAGACGGAGATCTGCTCTTACGCCCAGGCTAGAGTGAAGTGGCGCGATC
TTGGCTTACTGCAACCTCCACCCCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGATTACAGGCGCCCGCCACCAC
GTCCGGCTAATTTTTGTATTTTCAGTAGAGACGGGGTTTTGCTATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAAGTGATCCACCT
GCCTCGGCCTCCCAAAGTGTTAGGATAACAGGTGTGAGCCACCGTGCCCGGCTGAAGATTTTTCTTAATTGCAATAAATATTCAGCATTT
TTTCTAATGAAAATGAATTTTGTTTACCAGTAAAAGTATGCATTTTAAAAGACTTTCAGATTTATGCTTTTTACGTGAAGCTGCTAAACT
AAAAGTAAATGGAAGAAACCAAGTCTAGTAGGTTTTTTCTTTTTTTTTGTGGGGGTGGGATGGGGGAGGTTAGTTACACTTAAAATATCT
TCTCCAGAGACTGTATGCTCCTATACTAGACTGTAAGCTCTTTGAGGGCAGTCTGTCAGATTTATCTTTGTATCTTCCCCAGCGCCTAGT

>In-frame_ENST00000287916_ENST00000503362_TCGA-EJ-7783-01A_CLDN12_chr7_90045268_-_SPCS3_chr4_177243321_length(amino acids)=247AA_start in transcript=278_stop in transcript=1021
MPAMGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYDGSSDCLMYDTTWYSSVDQLDLRVLQ
FALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPVFSFDYAVYV

--------------------------------------------------------------
>In-frame_ENST00000535571_ENST00000503362_TCGA-EJ-7783-01A_CLDN12_chr7_90045268_-_SPCS3_chr4_177243321_length(transcript)=7902nt_BP=3587nt
ATTGCCGTTCAGGGCCACGGGAAAACCTGACTGCGCTCCCAGAAGCCTCCGGTGTACCTCGCTGGGAACGCACTTCCTGGGACGCTGAGA
GGGAGACGCTCCAAGAGGCTCCTCAGTGTGGGCGAGTAAAATGCCCTGCGTGTGAGAAGCAGGTAGGTGTGGTCAAGATGTTCCGATTTC
TGGGTCTTTTGCATAAGTAACTGAGGATTTTATGTAAAATGGCTAAATCCAGGAGAATCAGGAGCGTTGGAAAACGCTGACCACATCTGC
CCCTAGTCTGACTGACAGTACTCCACAAGCTTGCCTGCCATGGGCTGTCGGGATGTCCACGCAGCCACAGTCCTTTCCTTCCTGTGTGGA
ATCGCCTCAGTAGCAGGCCTCTTTGCAGGGACTCTGCTTCCCAACTGGAGAAAATTACGATTGATCACATTCAACAGAAACGAGAAGAAC
CTGACTGTTTACACAGGCCTGTGGGTGAAATGTGCCCGGTATGACGGGAGCAGTGACTGCCTGATGTACGACACTACTTGGTACTCATCA
GTTGACCAGCTGGACCTGCGTGTCCTCCAGTTTGCCCTACCCCTCAGCATGCTGATCGCCATGGGTGCCCTGCTGCTCTGCCTGATTGGA
ATGTGCAACACTGCCTTCAGGTCCTCGGTGCCCAACATCAAACTGGCCAAGTGTCTGGTCAATAGTGCAGGTTGCCACCTGGTGGCTGGG
CTGCTATTTTTCCTGGCAGGTACTGTGAGCCTCTCCCCATCTATCTGGGTCATCTTTTATAACATCCATCTGAACAAGAAGTTTGAGCCA
GTCTTTTCATTTGACTATGCAGTGTATGTCACTATTGCTAGTGCTGGGGGCCTGTTTATGACTTCCCTTATACTATTTATTTGGTATTGT
ACATGCAAATCTTTGCCTTCTCCTTTCTGGCAACCATTGTACTCCCATCCACCCAGTATGCATACTTACTCACAGCCCTATTCAGCACGC
TCTCGCCTCTCTGCCATTGAAATTGACATTCCAGTAGTTTCACACACCACTTAATGGGGAAATAGTTAATTGTTAAAGAAAACTTCTTGT
AGCCTCACATTCCCCTTGTGCAAAGAGCTCTTTTGGACCTACATACATTTTCCTTTGTTTTTGACCAATCAATGAAGCCAAATTTATATG
TCCTAGTAGAATGAAGTGCTGCTAGTTTTTATGAGAAGTATATTATATTAAATGTGAATTTTTTAAATTTTGCTTCTTATACTGGAAGGA
ATTTTAGCCTTCATATTGATATCTAATTAATTATTTAAGTGGAAGAGGCCTGCATCACAATTGAGGTAATGTAGAGCAACATGTTAAAGA
ATGATGGTTAGCAGAAGCTGTTGTATACAATCTTCATGAAAATTTCAGTGTGTATTTTTCTTTTTCTATAATACCTTTAACTGCAAAGAA
AAGGCAGTTTCAAATATAAGAAATTTATTTCAGGTAAGGGTAATATTTTAATAGTAGTCAATAATCTAGCTTAAGGCTGTAACTCTTCTA
TCGGGGCTAATTGTATGAATAGGTGTCAGTATGTTGAAGATTACTTTCTTTTGTGACTTTCTTCTACCTCATGCCACTGTTTAAAAGTAA
AACGTATTTTAACGATGTTAGAATAAGACTACCATTCTAAATATCACCTACTTATGAATAACATGTAATAATTTTTAACATTAATGATTC
CATAAATTGTATTATTGGGATTAGAATGTGCTTTATGACAGGTTAGTGTTTCCTCTGAGGCAGAAAACTCTTTTTTGGAGATATCTTCCA
TCAAGCAGTACTCGTGCCCATATACAATCTCTTAGTGGCTAGGAGAAATAAATAAAAGGGCCATAATGGTTTGTTCTCTTTCAGACATAA
TTTAGTAGGGGACAAGAAGTCTGTTCTTCAGTGAGTACACTAGAGATTTACTCTGGTGACTGCCTTTTGAGTTATGGGTGAAGTAAGGTA
TGGCTTTACCATAACCTTGATTCATTCACCCTTGATTCATTTCTCGCCCCCGTCACTGATTATTTCCTTGAGCATATATCTCTGCCTAAC
ACTTTAGTAGGTGCTATAGAGGATACATGAAAAGTATGAGATCTGGTTCCATCCAGTAAGACATTTTAATAGAGAAGATCAAAATGTTAC
CTGGCAGTTGGGGAATAATCTGACTTCGTTGGCAGTTGGCCTTAACTTCTTAATCATTGATCCAGGAATATTTCAACCAGAGACACAACT
TTCTGGCAGACAGACAAATTGTACAACACCAACAATATCCTGGACCTTGAAATTCTGTTTACTTCAGTCCATTGTATCCTTTAAGGCACC
TGTGCTAGCCTAGATTTTGTAATAACACTGATTTATGAGAATGGACAAAAGTGGTAGGGAAATTGTTCCCTCTCCACTTCTGAAAGTATG
ATGATGTATTAAGGATGGAGGAGTTATTAAAAATGTCTCTTCTGATGAGGTAACAATTAGATGAAACCATGTTAAAGCTGAGATGAACAC
TTAGAAATTCAGGGATATTGGGTCTTTAGCCTTATGAATTTGAGCTGCTTATTTAATTGGTGTAATTTACTACATATTAGTACTATATTC
GTAAGGATTTTTTATTAACCATTACAGATTTTACAAACAGCTAGTTATATGGTAAACAGATTATTATGCCTTTTTGCAATTCTGAATATG
ATTCTAGTATTTGTGTAGATGTATTTGGTACTTTTTCCCCTAATTCCAACACTAGTTTATATATATAGCGAATAAATCTAGTTGTATAAA
TTTTTAAATGCCGTCAGTAGAAAGCACACAAGGTTATGATTTTTTTAATTACTGGCTTCTGATTTCTTTCACTTCTGATCCTTTTCCTTT
TTCTCAGATGTAGCTGAGTCTTGATCATTTTAAGACAACGATGGGTAGAATTTTGAGATTAATGTTAATTTTCCCTTTTTGTTAATTTCA
GTCCCCTCTCACTATGCTTTTGTCCAGAAGGATCAAGAATTCTACCATCCCTTGGGTCTTTGTGTATAAACAATGTTAAATAAAGGTAGA
CTCAGTCTTTAAGATATTAGACAGTTTTTTTAGTCCATGGGATTGTAAATATAAACATTAACTTTCCTATAAGAATATTTTGGCTTTGTA
ATCTATAGCCTCAAATTGGTATTTATTATGGATTCACTAGACAAACAGCTGTTTCCTTATTGTCTTTTTTCTTTAGTGTTTCTGATTTGC
TATCAGTAGCTGTTTTTAAAGCCGTCCAAGGAAAATAATTATTTACAGTTTTTGAAGTCACTTTTGAGCCCTCATCAAGCTCTCATTGTG
ATGGGAGGGATACCTTTTTGTTGTTAAAAGCCTATTATTGTTAAAGGCCTTTTATGGAAACCAACTTGGAAAACAACCTTAAATGTGGAT
GTATCAGATTTGGTTTATCCAGCCATGGGAGAGAAAACAAACCTAAGTTTACTTTACTTGTACATATACACTACAATGGATAGTATATTT
GCTGTAAACTACAATGTAAAACCTCAATAAAAGTGCGCTGTACTTCTTAATGTTTATTAAAAGATGTATTTTTACAAAAAAAATGTAGAA
GATTTCACTGGACCTAGAGAAAGAAGTGATCTGGGATTTATCACATTTGATATAACTGCTGATCTAGAGAATATATTTGATTGGAATGTT
AAGCAGTTGTTTCTTTATTTATCAGCAGAATATTCAACAAAAAATAATGCTCTGAACCAAGTTGTCCTATGGGACAAGATTGTTTTGAGA
GGTGATAATCCGAAGCTGCTGCTGAAAGATATGAAAACAAAATATTTTTTCTTTGACGATGGAAATGGTCTCAAGGGAAACAGGAATGTC
ACTTTGACCCTGTCTTGGAACGTCGTACCAAATGCTGGAATTCTACCTCTTGTGACAGGATCAGGACACGTATCTGTCCCATTTCCAGAT
ACATATGAAATAACGAAGAGTTATTAAATTATTCTGAATTTGAAACAACATATTTTTATACTTAATGAATTGTATCTCATTAATCTCTTC
CCTTACATCTTCATGTATTGTTGGTTTGTTTTTTGGTTTTGGGTTTTTTTTTTTTTTTTTTTGGTATAAGAACTAACATCAAAAGGCCTG
TTTAAAGGGAAAGGTTAATGGGCTACTTAATATTATGAACAAAACAAAAAAACAAGGCTGCCACAGTGGAATATTATCTTACAAGAATAA
GAACTACATAAAACAGATTTGTAAAAAATACATATTTGAAGTATTCCCTGTATTTCCATTATTCTTTATGGAATATAAAGTAAGCATGAA
AGGTAGTTAAAACTTTCAGGTGCCTGTAGAGTCATAATAACTGTATTTTATGCCTTGCATTCACGCAAATTCACATTGGATGTGATTTAA
AAGTAGACATTCTCTTTTTCCTCTTTTAGGATATGTTTGATTACTGGAAAATTAATATGGTTATTTGTTAGAAGTCTGGTTTATAAAAAA
GCCAAAAGTGATGGAATTTATTCCATTTGTCTTAGGAAGGCCCATAATACTTGTTTTTCTTACATGTGACTAGCAACTTTCTCCACTTAA
AGACTAAATACCTCTTTATATGATGTAAATTATTCTAATTCATTTTAAAATCTTTTAGGTCAGCAAAATGTGTGTCTTCAGTGCTTTCTC
TAAAAACGTTCCTTTATAGCTTTGTACTTTTTTTTTTAGCGTTGCCATTGAAAGTTAAAATGTTTGCATGGTTTACCCTCTGAGTTATGT
TTCTTCTAGTGAGCATGCCTGCTGTCACTAAGTGAATTATTTACTACTTTTTGTAGGTCTATATTTTAATAATTATTGGGATAATAATAA
TTGTGGTATGCTTTCCATTTACAAACCACTCATATACTTTAGTGTATGTCATCCTCAATAATCTAATGAGGTAAGTAGTATAAGTGTTAG
CTCTTTGCAGATAAGAAACTGAAACCCAGAAGTTTATTGAATTGCTTCATTGTTACCTAGCCAGCAAGGAGTGGAATTAAAACTTGAACT
CAGATCTTCTAATTTTCTGAGCTCATCCTTTCTCTTATACCTCAGATTGCAGACTAATCAAATTTTACTTAAAACCTTCCTGATATTTTT
GTTACCCTGGACACCCTTTCTATTCTAGAAAAGGTTTCCCATTTTATATGGAAGTGACTAATTTTCAAGCTGCCAACAACTTATATCGAG
GTAATATTTTATTCTCTGAATAAATTCATTTCACTTATATTAAAAGCATAAGGAAATCTACATGTATGTAAAAATAACTTAGAAATTCAG
TACATAATACATGATTGAATACATGATCGTATTTAACATGTTTTTTTTTTCTGCAGTGGACAAATAAACATCCTCAAAGTAGCAACTGCA
AATCAGTTACCCTTAGAAAAGCAAGACCAAACACTGTAGTTACACTATTAGCAGTGACCAAAAAGGGCTAATATTTTCTAAGAATAGTTT
AAATTACAGACATTTGTTATATTTACCTTATGTGAAATACATCACTATTTAATTACATTAATTTTAACATCTGTTGTGTGGAGTTGTATA
GTTCATGCAAAAGCCTGTGGGTATGGGTTTTTCAAACCAGCAGAAAGGTCAAAGGTACCTGAATGCTAAACTGCCTGGCTCCCAGCTTTT
TCATTAAACTTTTCAGGGTCTTGGTTTCTTTATCTGTAAAATGACAGAGTTGGACCAGTTAACTTTAATGGCCATCCTTTTACACCACAC
AAGTTGATAAAATTTATCTGTTCAGCAAAGAGATTGAACAAAAAAGCACGTTAGTAATATGAAGACAGGAAAACGAATGAAAGTCTAACA
CATAACTCATATTGATTTACTTTATTTCTGTTAGATTTTACACTCTGAAAATTTCACCTCATTTAGTTTGTACAAATACTAGACATGGAA
ACTTAAAATGTGCAGGTGTCAAAGCTTAAAAATCAGGTGTGTCCTCTTTAAAGGCATGTGCGATAAGCCTGCAGTCTTAACCAGACCTGG
TACCAGTTTAACAGTTCATGATACTTCTGTGATGAGTGGATCTGTTAGTCTGGTAGAGATTAATGTTGAAATTTACTTGAATTACAGTTA
TTTGACAAGCCCACTTTTTTTGGAGTTTGGTGAGGAAGATAAGTAAAAATGCCCAACTAGTACAATGTGGAGAAAGTTTTCTGTTTGCTT
GACTAAGGGAAATTGCTCAGAAAAAGAATGCTCCAACATGGGAATAAGGACCTTCAGTCTCAGGAACTCATTTTTGGGTGCAGTTTCTAC
ATTTAAAAAATTGACTTGTGTTCAGTTTGATAACCAGTTCATTTGCTTTAGTCTCAGTGTTTTAAAGAAGTCTCATAATGTTCTACAAAG
ACACAAAGCTTCAGGCTTATACAAAACTGAGTATGATTAGAAATACCTGAGCCCAGAAATGATTCTGAGAAAAGAGAATAATTTGAAGAC
ACTTATTTAAAAGTAATTATGGTTAGAAATGAATTAATTTAAAAATGTGTTCACATATCCCTTTCTCTAACAGTTTAACCTAGACAAACA
TCTGTATCAGTATTTTTTTATTCCCCTGATTGATTACATTTGGTTTCTTTATTCTGAAAGGAAAATAACAAAAACTTCAGAAATTCCTAA
GGGTGTAATAAGAAAGTGGGTTTTGAGTTTCCTTTCCTGGAATTATTTTACAGTTCTTTGGTGGGTCTCGTCAGCCAATTCATAGCTGGG
CTTTAAGATTATCATCTTAGAGATGATAGATGGGCTTTTTAAAGATTTCATCTTAGAGATGAAAAGCTGGGCTTTTTCTCTAAGATGATA
ATCTTAAAGCCCAGCTATTAATTGATAATGAACATTTTTCACTATTTTTTTTTCTATCTGAAGCTTAGAGATCTAGAGCTTTGGATCTTT
CGGGTATATGTCAATGGAGGTATTATTTTATAATACTTTGCATTGACATGAAGTGGGTTCATGGGGGAAAACCATGAGCTGTGAACATTG
GTAGCAAACAAGCATATATTCATTTCAAAACTTTCCTTGCTTTTAGCAGAGAGAAGCCTGTATATGTTACATGTGTGACTTTCAGTAGTT
TAAAGAGATGTTTCAAAAAATTGTTGCATGTTTTTGATGCAATTTGGGAAATTGTTTACTTCACAATGTAGTCATTCATAAAAAAATTCA
TGAAAATACTGAACATATGTTTGAGGATTTTTCTTTTCCTTTTTAAATTTTTTTATTTTTTCTGAGACGGAGATCTGCTCTTACGCCCAG
GCTAGAGTGAAGTGGCGCGATCTTGGCTTACTGCAACCTCCACCCCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGG
GATTACAGGCGCCCGCCACCACGTCCGGCTAATTTTTGTATTTTCAGTAGAGACGGGGTTTTGCTATGTTGGCCAGGCTGGTCTCAAACT
CCTGACCTCAAGTGATCCACCTGCCTCGGCCTCCCAAAGTGTTAGGATAACAGGTGTGAGCCACCGTGCCCGGCTGAAGATTTTTCTTAA
TTGCAATAAATATTCAGCATTTTTTCTAATGAAAATGAATTTTGTTTACCAGTAAAAGTATGCATTTTAAAAGACTTTCAGATTTATGCT
TTTTACGTGAAGCTGCTAAACTAAAAGTAAATGGAAGAAACCAAGTCTAGTAGGTTTTTTCTTTTTTTTTGTGGGGGTGGGATGGGGGAG
GTTAGTTACACTTAAAATATCTTCTCCAGAGACTGTATGCTCCTATACTAGACTGTAAGCTCTTTGAGGGCAGTCTGTCAGATTTATCTT

>In-frame_ENST00000535571_ENST00000503362_TCGA-EJ-7783-01A_CLDN12_chr7_90045268_-_SPCS3_chr4_177243321_length(amino acids)=247AA_start in transcript=300_stop in transcript=1043
MPAMGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYDGSSDCLMYDTTWYSSVDQLDLRVLQ
FALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPVFSFDYAVYV

--------------------------------------------------------------
>In-frame_ENST00000394605_ENST00000503362_TCGA-EJ-7783-01A_CLDN12_chr7_90045268_-_SPCS3_chr4_177243321_length(transcript)=7803nt_BP=3488nt
GCACTTCCTGGGACGCTGAGAGGGAGACGCTCCAAGAGGCTCCTCAGTGTGGGCGAGTAAAATGCCCTGCGTGTGAGAAGCAGGCTCAGA
TTATTGCTACTCTGTATTCAGATCTTCATGTGTCTCTTCTAAGCTGAATAAAGCTGTTTTGGAACTGTCAGGTACCTCAAAGCGTAATCT
GACTGACAGTACTCCACAAGCTTGCCTGCCATGGGCTGTCGGGATGTCCACGCAGCCACAGTCCTTTCCTTCCTGTGTGGAATCGCCTCA
GTAGCAGGCCTCTTTGCAGGGACTCTGCTTCCCAACTGGAGAAAATTACGATTGATCACATTCAACAGAAACGAGAAGAACCTGACTGTT
TACACAGGCCTGTGGGTGAAATGTGCCCGGTATGACGGGAGCAGTGACTGCCTGATGTACGACACTACTTGGTACTCATCAGTTGACCAG
CTGGACCTGCGTGTCCTCCAGTTTGCCCTACCCCTCAGCATGCTGATCGCCATGGGTGCCCTGCTGCTCTGCCTGATTGGAATGTGCAAC
ACTGCCTTCAGGTCCTCGGTGCCCAACATCAAACTGGCCAAGTGTCTGGTCAATAGTGCAGGTTGCCACCTGGTGGCTGGGCTGCTATTT
TTCCTGGCAGGTACTGTGAGCCTCTCCCCATCTATCTGGGTCATCTTTTATAACATCCATCTGAACAAGAAGTTTGAGCCAGTCTTTTCA
TTTGACTATGCAGTGTATGTCACTATTGCTAGTGCTGGGGGCCTGTTTATGACTTCCCTTATACTATTTATTTGGTATTGTACATGCAAA
TCTTTGCCTTCTCCTTTCTGGCAACCATTGTACTCCCATCCACCCAGTATGCATACTTACTCACAGCCCTATTCAGCACGCTCTCGCCTC
TCTGCCATTGAAATTGACATTCCAGTAGTTTCACACACCACTTAATGGGGAAATAGTTAATTGTTAAAGAAAACTTCTTGTAGCCTCACA
TTCCCCTTGTGCAAAGAGCTCTTTTGGACCTACATACATTTTCCTTTGTTTTTGACCAATCAATGAAGCCAAATTTATATGTCCTAGTAG
AATGAAGTGCTGCTAGTTTTTATGAGAAGTATATTATATTAAATGTGAATTTTTTAAATTTTGCTTCTTATACTGGAAGGAATTTTAGCC
TTCATATTGATATCTAATTAATTATTTAAGTGGAAGAGGCCTGCATCACAATTGAGGTAATGTAGAGCAACATGTTAAAGAATGATGGTT
AGCAGAAGCTGTTGTATACAATCTTCATGAAAATTTCAGTGTGTATTTTTCTTTTTCTATAATACCTTTAACTGCAAAGAAAAGGCAGTT
TCAAATATAAGAAATTTATTTCAGGTAAGGGTAATATTTTAATAGTAGTCAATAATCTAGCTTAAGGCTGTAACTCTTCTATCGGGGCTA
ATTGTATGAATAGGTGTCAGTATGTTGAAGATTACTTTCTTTTGTGACTTTCTTCTACCTCATGCCACTGTTTAAAAGTAAAACGTATTT
TAACGATGTTAGAATAAGACTACCATTCTAAATATCACCTACTTATGAATAACATGTAATAATTTTTAACATTAATGATTCCATAAATTG
TATTATTGGGATTAGAATGTGCTTTATGACAGGTTAGTGTTTCCTCTGAGGCAGAAAACTCTTTTTTGGAGATATCTTCCATCAAGCAGT
ACTCGTGCCCATATACAATCTCTTAGTGGCTAGGAGAAATAAATAAAAGGGCCATAATGGTTTGTTCTCTTTCAGACATAATTTAGTAGG
GGACAAGAAGTCTGTTCTTCAGTGAGTACACTAGAGATTTACTCTGGTGACTGCCTTTTGAGTTATGGGTGAAGTAAGGTATGGCTTTAC
CATAACCTTGATTCATTCACCCTTGATTCATTTCTCGCCCCCGTCACTGATTATTTCCTTGAGCATATATCTCTGCCTAACACTTTAGTA
GGTGCTATAGAGGATACATGAAAAGTATGAGATCTGGTTCCATCCAGTAAGACATTTTAATAGAGAAGATCAAAATGTTACCTGGCAGTT
GGGGAATAATCTGACTTCGTTGGCAGTTGGCCTTAACTTCTTAATCATTGATCCAGGAATATTTCAACCAGAGACACAACTTTCTGGCAG
ACAGACAAATTGTACAACACCAACAATATCCTGGACCTTGAAATTCTGTTTACTTCAGTCCATTGTATCCTTTAAGGCACCTGTGCTAGC
CTAGATTTTGTAATAACACTGATTTATGAGAATGGACAAAAGTGGTAGGGAAATTGTTCCCTCTCCACTTCTGAAAGTATGATGATGTAT
TAAGGATGGAGGAGTTATTAAAAATGTCTCTTCTGATGAGGTAACAATTAGATGAAACCATGTTAAAGCTGAGATGAACACTTAGAAATT
CAGGGATATTGGGTCTTTAGCCTTATGAATTTGAGCTGCTTATTTAATTGGTGTAATTTACTACATATTAGTACTATATTCGTAAGGATT
TTTTATTAACCATTACAGATTTTACAAACAGCTAGTTATATGGTAAACAGATTATTATGCCTTTTTGCAATTCTGAATATGATTCTAGTA
TTTGTGTAGATGTATTTGGTACTTTTTCCCCTAATTCCAACACTAGTTTATATATATAGCGAATAAATCTAGTTGTATAAATTTTTAAAT
GCCGTCAGTAGAAAGCACACAAGGTTATGATTTTTTTAATTACTGGCTTCTGATTTCTTTCACTTCTGATCCTTTTCCTTTTTCTCAGAT
GTAGCTGAGTCTTGATCATTTTAAGACAACGATGGGTAGAATTTTGAGATTAATGTTAATTTTCCCTTTTTGTTAATTTCAGTCCCCTCT
CACTATGCTTTTGTCCAGAAGGATCAAGAATTCTACCATCCCTTGGGTCTTTGTGTATAAACAATGTTAAATAAAGGTAGACTCAGTCTT
TAAGATATTAGACAGTTTTTTTAGTCCATGGGATTGTAAATATAAACATTAACTTTCCTATAAGAATATTTTGGCTTTGTAATCTATAGC
CTCAAATTGGTATTTATTATGGATTCACTAGACAAACAGCTGTTTCCTTATTGTCTTTTTTCTTTAGTGTTTCTGATTTGCTATCAGTAG
CTGTTTTTAAAGCCGTCCAAGGAAAATAATTATTTACAGTTTTTGAAGTCACTTTTGAGCCCTCATCAAGCTCTCATTGTGATGGGAGGG
ATACCTTTTTGTTGTTAAAAGCCTATTATTGTTAAAGGCCTTTTATGGAAACCAACTTGGAAAACAACCTTAAATGTGGATGTATCAGAT
TTGGTTTATCCAGCCATGGGAGAGAAAACAAACCTAAGTTTACTTTACTTGTACATATACACTACAATGGATAGTATATTTGCTGTAAAC
TACAATGTAAAACCTCAATAAAAGTGCGCTGTACTTCTTAATGTTTATTAAAAGATGTATTTTTACAAAAAAAATGTAGAAGATTTCACT
GGACCTAGAGAAAGAAGTGATCTGGGATTTATCACATTTGATATAACTGCTGATCTAGAGAATATATTTGATTGGAATGTTAAGCAGTTG
TTTCTTTATTTATCAGCAGAATATTCAACAAAAAATAATGCTCTGAACCAAGTTGTCCTATGGGACAAGATTGTTTTGAGAGGTGATAAT
CCGAAGCTGCTGCTGAAAGATATGAAAACAAAATATTTTTTCTTTGACGATGGAAATGGTCTCAAGGGAAACAGGAATGTCACTTTGACC
CTGTCTTGGAACGTCGTACCAAATGCTGGAATTCTACCTCTTGTGACAGGATCAGGACACGTATCTGTCCCATTTCCAGATACATATGAA
ATAACGAAGAGTTATTAAATTATTCTGAATTTGAAACAACATATTTTTATACTTAATGAATTGTATCTCATTAATCTCTTCCCTTACATC
TTCATGTATTGTTGGTTTGTTTTTTGGTTTTGGGTTTTTTTTTTTTTTTTTTTGGTATAAGAACTAACATCAAAAGGCCTGTTTAAAGGG
AAAGGTTAATGGGCTACTTAATATTATGAACAAAACAAAAAAACAAGGCTGCCACAGTGGAATATTATCTTACAAGAATAAGAACTACAT
AAAACAGATTTGTAAAAAATACATATTTGAAGTATTCCCTGTATTTCCATTATTCTTTATGGAATATAAAGTAAGCATGAAAGGTAGTTA
AAACTTTCAGGTGCCTGTAGAGTCATAATAACTGTATTTTATGCCTTGCATTCACGCAAATTCACATTGGATGTGATTTAAAAGTAGACA
TTCTCTTTTTCCTCTTTTAGGATATGTTTGATTACTGGAAAATTAATATGGTTATTTGTTAGAAGTCTGGTTTATAAAAAAGCCAAAAGT
GATGGAATTTATTCCATTTGTCTTAGGAAGGCCCATAATACTTGTTTTTCTTACATGTGACTAGCAACTTTCTCCACTTAAAGACTAAAT
ACCTCTTTATATGATGTAAATTATTCTAATTCATTTTAAAATCTTTTAGGTCAGCAAAATGTGTGTCTTCAGTGCTTTCTCTAAAAACGT
TCCTTTATAGCTTTGTACTTTTTTTTTTAGCGTTGCCATTGAAAGTTAAAATGTTTGCATGGTTTACCCTCTGAGTTATGTTTCTTCTAG
TGAGCATGCCTGCTGTCACTAAGTGAATTATTTACTACTTTTTGTAGGTCTATATTTTAATAATTATTGGGATAATAATAATTGTGGTAT
GCTTTCCATTTACAAACCACTCATATACTTTAGTGTATGTCATCCTCAATAATCTAATGAGGTAAGTAGTATAAGTGTTAGCTCTTTGCA
GATAAGAAACTGAAACCCAGAAGTTTATTGAATTGCTTCATTGTTACCTAGCCAGCAAGGAGTGGAATTAAAACTTGAACTCAGATCTTC
TAATTTTCTGAGCTCATCCTTTCTCTTATACCTCAGATTGCAGACTAATCAAATTTTACTTAAAACCTTCCTGATATTTTTGTTACCCTG
GACACCCTTTCTATTCTAGAAAAGGTTTCCCATTTTATATGGAAGTGACTAATTTTCAAGCTGCCAACAACTTATATCGAGGTAATATTT
TATTCTCTGAATAAATTCATTTCACTTATATTAAAAGCATAAGGAAATCTACATGTATGTAAAAATAACTTAGAAATTCAGTACATAATA
CATGATTGAATACATGATCGTATTTAACATGTTTTTTTTTTCTGCAGTGGACAAATAAACATCCTCAAAGTAGCAACTGCAAATCAGTTA
CCCTTAGAAAAGCAAGACCAAACACTGTAGTTACACTATTAGCAGTGACCAAAAAGGGCTAATATTTTCTAAGAATAGTTTAAATTACAG
ACATTTGTTATATTTACCTTATGTGAAATACATCACTATTTAATTACATTAATTTTAACATCTGTTGTGTGGAGTTGTATAGTTCATGCA
AAAGCCTGTGGGTATGGGTTTTTCAAACCAGCAGAAAGGTCAAAGGTACCTGAATGCTAAACTGCCTGGCTCCCAGCTTTTTCATTAAAC
TTTTCAGGGTCTTGGTTTCTTTATCTGTAAAATGACAGAGTTGGACCAGTTAACTTTAATGGCCATCCTTTTACACCACACAAGTTGATA
AAATTTATCTGTTCAGCAAAGAGATTGAACAAAAAAGCACGTTAGTAATATGAAGACAGGAAAACGAATGAAAGTCTAACACATAACTCA
TATTGATTTACTTTATTTCTGTTAGATTTTACACTCTGAAAATTTCACCTCATTTAGTTTGTACAAATACTAGACATGGAAACTTAAAAT
GTGCAGGTGTCAAAGCTTAAAAATCAGGTGTGTCCTCTTTAAAGGCATGTGCGATAAGCCTGCAGTCTTAACCAGACCTGGTACCAGTTT
AACAGTTCATGATACTTCTGTGATGAGTGGATCTGTTAGTCTGGTAGAGATTAATGTTGAAATTTACTTGAATTACAGTTATTTGACAAG
CCCACTTTTTTTGGAGTTTGGTGAGGAAGATAAGTAAAAATGCCCAACTAGTACAATGTGGAGAAAGTTTTCTGTTTGCTTGACTAAGGG
AAATTGCTCAGAAAAAGAATGCTCCAACATGGGAATAAGGACCTTCAGTCTCAGGAACTCATTTTTGGGTGCAGTTTCTACATTTAAAAA
ATTGACTTGTGTTCAGTTTGATAACCAGTTCATTTGCTTTAGTCTCAGTGTTTTAAAGAAGTCTCATAATGTTCTACAAAGACACAAAGC
TTCAGGCTTATACAAAACTGAGTATGATTAGAAATACCTGAGCCCAGAAATGATTCTGAGAAAAGAGAATAATTTGAAGACACTTATTTA
AAAGTAATTATGGTTAGAAATGAATTAATTTAAAAATGTGTTCACATATCCCTTTCTCTAACAGTTTAACCTAGACAAACATCTGTATCA
GTATTTTTTTATTCCCCTGATTGATTACATTTGGTTTCTTTATTCTGAAAGGAAAATAACAAAAACTTCAGAAATTCCTAAGGGTGTAAT
AAGAAAGTGGGTTTTGAGTTTCCTTTCCTGGAATTATTTTACAGTTCTTTGGTGGGTCTCGTCAGCCAATTCATAGCTGGGCTTTAAGAT
TATCATCTTAGAGATGATAGATGGGCTTTTTAAAGATTTCATCTTAGAGATGAAAAGCTGGGCTTTTTCTCTAAGATGATAATCTTAAAG
CCCAGCTATTAATTGATAATGAACATTTTTCACTATTTTTTTTTCTATCTGAAGCTTAGAGATCTAGAGCTTTGGATCTTTCGGGTATAT
GTCAATGGAGGTATTATTTTATAATACTTTGCATTGACATGAAGTGGGTTCATGGGGGAAAACCATGAGCTGTGAACATTGGTAGCAAAC
AAGCATATATTCATTTCAAAACTTTCCTTGCTTTTAGCAGAGAGAAGCCTGTATATGTTACATGTGTGACTTTCAGTAGTTTAAAGAGAT
GTTTCAAAAAATTGTTGCATGTTTTTGATGCAATTTGGGAAATTGTTTACTTCACAATGTAGTCATTCATAAAAAAATTCATGAAAATAC
TGAACATATGTTTGAGGATTTTTCTTTTCCTTTTTAAATTTTTTTATTTTTTCTGAGACGGAGATCTGCTCTTACGCCCAGGCTAGAGTG
AAGTGGCGCGATCTTGGCTTACTGCAACCTCCACCCCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAGCTGGGATTACAGG
CGCCCGCCACCACGTCCGGCTAATTTTTGTATTTTCAGTAGAGACGGGGTTTTGCTATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTC
AAGTGATCCACCTGCCTCGGCCTCCCAAAGTGTTAGGATAACAGGTGTGAGCCACCGTGCCCGGCTGAAGATTTTTCTTAATTGCAATAA
ATATTCAGCATTTTTTCTAATGAAAATGAATTTTGTTTACCAGTAAAAGTATGCATTTTAAAAGACTTTCAGATTTATGCTTTTTACGTG
AAGCTGCTAAACTAAAAGTAAATGGAAGAAACCAAGTCTAGTAGGTTTTTTCTTTTTTTTTGTGGGGGTGGGATGGGGGAGGTTAGTTAC
ACTTAAAATATCTTCTCCAGAGACTGTATGCTCCTATACTAGACTGTAAGCTCTTTGAGGGCAGTCTGTCAGATTTATCTTTGTATCTTC

>In-frame_ENST00000394605_ENST00000503362_TCGA-EJ-7783-01A_CLDN12_chr7_90045268_-_SPCS3_chr4_177243321_length(amino acids)=247AA_start in transcript=201_stop in transcript=944
MPAMGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYDGSSDCLMYDTTWYSSVDQLDLRVLQ
FALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPVFSFDYAVYV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CLDN12-SPCS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CLDN12-SPCS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CLDN12-SPCS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource