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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CLK3-CAPN8 (FusionGDB2 ID:17230)

Fusion Gene Summary for CLK3-CAPN8

check button Fusion gene summary
Fusion gene informationFusion gene name: CLK3-CAPN8
Fusion gene ID: 17230
HgeneTgene
Gene symbol

CLK3

CAPN8

Gene ID

1198

388743

Gene nameCDC like kinase 3calpain 8
SynonymsPHCLK3|PHCLK3/152nCL-2
Cytomap

15q24.1

1q41

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein kinase CLK3calpain-8new calpain 2stomach-specific M-type calpain
Modification date2020031320200313
UniProtAcc.

A6NHC0

Ensembl transtripts involved in fusion geneENST00000564353, ENST00000345005, 
ENST00000395066, ENST00000348245, 
ENST00000352989, 		ENST00000366872, 
ENST00000366873, 
Fusion gene scores* DoF score6 X 6 X 4=14412 X 2 X 4=96
# samples 612
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/96*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CLK3 [Title/Abstract] AND CAPN8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLK3(74912566)-CAPN8(223718212), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLK3

GO:0006468

protein phosphorylation

9637771

HgeneCLK3

GO:0043484

regulation of RNA splicing

9637771


check buttonFusion gene breakpoints across CLK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CAPN8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer215NCLK3chr15

74912566

+CAPN8chr1

223718212

-


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Fusion Gene ORF analysis for CLK3-CAPN8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000564353ENST00000366872CLK3chr15

74912566

+CAPN8chr1

223718212

-
intron-intronENST00000564353ENST00000366873CLK3chr15

74912566

+CAPN8chr1

223718212

-
In-frameENST00000345005ENST00000366872CLK3chr15

74912566

+CAPN8chr1

223718212

-
5CDS-intronENST00000345005ENST00000366873CLK3chr15

74912566

+CAPN8chr1

223718212

-
In-frameENST00000395066ENST00000366872CLK3chr15

74912566

+CAPN8chr1

223718212

-
5CDS-intronENST00000395066ENST00000366873CLK3chr15

74912566

+CAPN8chr1

223718212

-
In-frameENST00000348245ENST00000366872CLK3chr15

74912566

+CAPN8chr1

223718212

-
5CDS-intronENST00000348245ENST00000366873CLK3chr15

74912566

+CAPN8chr1

223718212

-
In-frameENST00000352989ENST00000366872CLK3chr15

74912566

+CAPN8chr1

223718212

-
5CDS-intronENST00000352989ENST00000366873CLK3chr15

74912566

+CAPN8chr1

223718212

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000345005CLK3chr1574912566+ENST00000366872CAPN8chr1223718212-91942422702226
ENST00000395066CLK3chr1574912566+ENST00000366872CAPN8chr1223718212-176912742991552417
ENST00000348245CLK3chr1574912566+ENST00000366872CAPN8chr1223718212-88939425672215
ENST00000352989CLK3chr1574912566+ENST00000366872CAPN8chr1223718212-88939425672215

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000345005ENST00000366872CLK3chr1574912566+CAPN8chr1223718212-0.0562308060.9437692
ENST00000395066ENST00000366872CLK3chr1574912566+CAPN8chr1223718212-0.155619430.8443806
ENST00000348245ENST00000366872CLK3chr1574912566+CAPN8chr1223718212-0.0551832730.9448167
ENST00000352989ENST00000366872CLK3chr1574912566+CAPN8chr1223718212-0.0551832730.9448167

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Fusion Genomic Features for CLK3-CAPN8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CLK3-CAPN8


check button Go to

FGviewer for the breakpoints of chr15:74912566-chr1:223718212

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAPN8

A6NHC0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLK3chr15:74912566chr1:223718212ENST00000395066+313167_264271.0639.0Compositional biasNote=Arg-rich
TgeneCAPN8chr15:74912566chr1:223718212ENST000003668721520588_599589.0682.0Calcium binding1
TgeneCAPN8chr15:74912566chr1:223718212ENST000003668721520618_629589.0682.0Calcium binding2
TgeneCAPN8chr15:74912566chr1:223718212ENST000003668721520605_640589.0682.0DomainEF-hand 2
TgeneCAPN8chr15:74912566chr1:223718212ENST000003668721520670_703589.0682.0DomainEF-hand 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLK3chr15:74912566chr1:223718212ENST00000345005+313167_264123.0491.0Compositional biasNote=Arg-rich
HgeneCLK3chr15:74912566chr1:223718212ENST00000348245+312167_264123.0225.0Compositional biasNote=Arg-rich
HgeneCLK3chr15:74912566chr1:223718212ENST00000345005+313304_620123.0491.0DomainProtein kinase
HgeneCLK3chr15:74912566chr1:223718212ENST00000348245+312304_620123.0225.0DomainProtein kinase
HgeneCLK3chr15:74912566chr1:223718212ENST00000395066+313304_620271.0639.0DomainProtein kinase
HgeneCLK3chr15:74912566chr1:223718212ENST00000345005+313310_318123.0491.0Nucleotide bindingATP
HgeneCLK3chr15:74912566chr1:223718212ENST00000348245+312310_318123.0225.0Nucleotide bindingATP
HgeneCLK3chr15:74912566chr1:223718212ENST00000395066+313310_318271.0639.0Nucleotide bindingATP
TgeneCAPN8chr15:74912566chr1:223718212ENST00000366872152045_344589.0682.0DomainCalpain catalytic
TgeneCAPN8chr15:74912566chr1:223718212ENST000003668721520575_610589.0682.0DomainEF-hand 1
TgeneCAPN8chr15:74912566chr1:223718212ENST000003668721520356_379589.0682.0RegionNote=Domain III


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Fusion Gene Sequence for CLK3-CAPN8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000345005_ENST00000366872_215N_CLK3_chr15_74912566_+_CAPN8_chr1_223718212_length(transcript)=919nt_BP=424nt
GGGGCACTGGTACCTCCAGGACCTGGAGTGTACTGGAAGAAATGGTGCAGTCCAGATGCATCACTGTAAGCGATACCGCTCCCCTGAACC
AGACCCGTACCTGAGCTACCGATGGAAGAGGAGGAGGTCCTACAGTCGGGAACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCC
TCCCCCACGAAGATCTCGGTCCAGAAGCCATGACCGCCTGCCCTACCAGAGGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTG
TGAAGAGCGGAGCCCATCCTTTGGAGAGGACTACTATGGACCTTCACGTTCTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCG
GACCCGCAAGCATGCCCACCACTGCCACAAACGCCGCACCAGGTCTTGTAGCAGCGCCTCCTCGGAGATCTATTGGGAAACTGATTATAA
CCACTCGGGCACCATCGATGCCCACGAGATGAGGACAGCCCTCAGGAAGGCAGGTTTCACCCTCAACAGCCAGGTGCAGCAGACCATTGC
CCTGCGGTATGCGTGCAGCAAGCTCGGCATCAACTTTGACAGCTTCGTGGCTTGTATGATCCGCCTGGAGACCCTCTTCAAACTATTCAG
CCTTCTGGACGAAGACAAGGATGGCATGGTTCAGCTCTCTCTGGCCGAGTGGCTGTGCTGCGTGTTGGTCTGACCCGGGGTTTCGGACAT
CAGTGACACTCCCTGCCCCACTGCTTGCTTCTTGTCACCCCTTCTCTACAATTTTGTGAACATTTATGCTCCAGTGGCATTCACTGGTTG
TTCATACCTTTCTTGCCCTGGGTCTATTTCAGCAGCACTGAGCTATGAGCTATGTAAGCCGACCCGGTGGGCCCAGTGGAGGGAAAGCAA

>In-frame_ENST00000345005_ENST00000366872_215N_CLK3_chr15_74912566_+_CAPN8_chr1_223718212_length(amino acids)=226AA_start in transcript=22_stop in transcript=702
MECTGRNGAVQMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSF
GEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSK

--------------------------------------------------------------
>In-frame_ENST00000395066_ENST00000366872_215N_CLK3_chr15_74912566_+_CAPN8_chr1_223718212_length(transcript)=1769nt_BP=1274nt
AGTTTTCTCATCTGGAAAGTGGGGCCTCGTAATCCTGTCCGACCCGGCGCGGGACAGTAGGTGTCAGGGATTTTGGTGACCCCACGCTCG
AGGCCTCTGCAAAAGGGGGCTGTCCAGTGGCCCAGAGACGCAGCCGGCGGGGCTTTTGTCTAGCGGGGGAGTCTTAACTGAGAGGCCACG
CAGGCCGGCAGGAAGCCGCTCCACAGGAGGGGGCTCAAGGAGAGGGGATCTCCTCCCTCCAGACTCCGGCCCCGCCAGAGTAGCTCTAGG
GTATCTTCCCAGAAACTGCCCCGCACGCACTGGCGAGCTGGGAGCGCCACCACGGCTTTCAAAAAACCCGCACACACCAAGATAATAATG
TGTCGTTCGCTCGTTTCGCGCAAGCGGAGTCGCGTCCGCCTTCCCGAGCTCCGGCACACAGACCTCAGGCCGCTCTCGCGCTCTCCGGGG
CCCCGAGAACAATGCCCGTCCTCTCCGCGCGCAGGAGGGAGTTGGCGGACCACGCGGGGTCGGGGCGACGGAGCGGGCCCAGCCCCACGG
CCAGGTCGGGGCCCCACCTCTCGGCTCTGAGAGCCCAGCCGGCCCGGGCCGCGCACCTGTCAGGTCGGGGGACCTACGTGCGCCGCGACA
CGGCGGGAGGCGGGCCGGGCCAGGCTCGTCCCCTCGGCCCTCCCGGAACTAGTCTCCTAGGCCGCGGCGCCCGCCGGAGCGGAGAGGGCT
GGTGCCCCGGAGCCTTCGAGTCGGGGGCTAGAGCGGCCAGGCCTCCGAGCCGGGTCGAGCCGAGGCTGGCGACGGCTGCGTCACGCGAGG
GGGCGGGGCTGCCACGGGCGGAGGTCGCAGCCGGAAGCGGAAGAGGCGCTCGGAGCGGGGAGTGGGGCCTAGCTGCAGCCGGAGCCTGGG
AGACGATGCATCACTGTAAGCGATACCGCTCCCCTGAACCAGACCCGTACCTGAGCTACCGATGGAAGAGGAGGAGGTCCTACAGTCGGG
AACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCCTCCCCCACGAAGATCTCGGTCCAGAAGCCATGACCGCCTGCCCTACCAGA
GGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTGTGAAGAGCGGAGCCCATCCTTTGGAGAGGACTACTATGGACCTTCACGTT
CTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCGGACCCGCAAGCATGCCCACCACTGCCACAAACGCCGCACCAGGTCTTGTA
GCAGCGCCTCCTCGGAGATCTATTGGGAAACTGATTATAACCACTCGGGCACCATCGATGCCCACGAGATGAGGACAGCCCTCAGGAAGG
CAGGTTTCACCCTCAACAGCCAGGTGCAGCAGACCATTGCCCTGCGGTATGCGTGCAGCAAGCTCGGCATCAACTTTGACAGCTTCGTGG
CTTGTATGATCCGCCTGGAGACCCTCTTCAAACTATTCAGCCTTCTGGACGAAGACAAGGATGGCATGGTTCAGCTCTCTCTGGCCGAGT
GGCTGTGCTGCGTGTTGGTCTGACCCGGGGTTTCGGACATCAGTGACACTCCCTGCCCCACTGCTTGCTTCTTGTCACCCCTTCTCTACA
ATTTTGTGAACATTTATGCTCCAGTGGCATTCACTGGTTGTTCATACCTTTCTTGCCCTGGGTCTATTTCAGCAGCACTGAGCTATGAGC

>In-frame_ENST00000395066_ENST00000366872_215N_CLK3_chr15_74912566_+_CAPN8_chr1_223718212_length(amino acids)=417AA_start in transcript=299_stop in transcript=1552
MASWERHHGFQKTRTHQDNNVSFARFAQAESRPPSRAPAHRPQAALALSGAPRTMPVLSARRRELADHAGSGRRSGPSPTARSGPHLSAL
RAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVA
AGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSD
TYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQ

--------------------------------------------------------------
>In-frame_ENST00000348245_ENST00000366872_215N_CLK3_chr15_74912566_+_CAPN8_chr1_223718212_length(transcript)=889nt_BP=394nt
AGCTGCAGCCGGAGCCTGGGAGACGATGCATCACTGTAAGCGATACCGCTCCCCTGAACCAGACCCGTACCTGAGCTACCGATGGAAGAG
GAGGAGGTCCTACAGTCGGGAACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCCTCCCCCACGAAGATCTCGGTCCAGAAGCCA
TGACCGCCTGCCCTACCAGAGGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTGTGAAGAGCGGAGCCCATCCTTTGGAGAGGA
CTACTATGGACCTTCACGTTCTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCGGACCCGCAAGCATGCCCACCACTGCCACAA
ACGCCGCACCAGGTCTTGTAGCAGCGCCTCCTCGGAGATCTATTGGGAAACTGATTATAACCACTCGGGCACCATCGATGCCCACGAGAT
GAGGACAGCCCTCAGGAAGGCAGGTTTCACCCTCAACAGCCAGGTGCAGCAGACCATTGCCCTGCGGTATGCGTGCAGCAAGCTCGGCAT
CAACTTTGACAGCTTCGTGGCTTGTATGATCCGCCTGGAGACCCTCTTCAAACTATTCAGCCTTCTGGACGAAGACAAGGATGGCATGGT
TCAGCTCTCTCTGGCCGAGTGGCTGTGCTGCGTGTTGGTCTGACCCGGGGTTTCGGACATCAGTGACACTCCCTGCCCCACTGCTTGCTT
CTTGTCACCCCTTCTCTACAATTTTGTGAACATTTATGCTCCAGTGGCATTCACTGGTTGTTCATACCTTTCTTGCCCTGGGTCTATTTC

>In-frame_ENST00000348245_ENST00000366872_215N_CLK3_chr15_74912566_+_CAPN8_chr1_223718212_length(amino acids)=215AA_start in transcript=25_stop in transcript=672
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSR
HRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVAC

--------------------------------------------------------------
>In-frame_ENST00000352989_ENST00000366872_215N_CLK3_chr15_74912566_+_CAPN8_chr1_223718212_length(transcript)=889nt_BP=394nt
AGCTGCAGCCGGAGCCTGGGAGACGATGCATCACTGTAAGCGATACCGCTCCCCTGAACCAGACCCGTACCTGAGCTACCGATGGAAGAG
GAGGAGGTCCTACAGTCGGGAACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCCTCCCCCACGAAGATCTCGGTCCAGAAGCCA
TGACCGCCTGCCCTACCAGAGGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTGTGAAGAGCGGAGCCCATCCTTTGGAGAGGA
CTACTATGGACCTTCACGTTCTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCGGACCCGCAAGCATGCCCACCACTGCCACAA
ACGCCGCACCAGGTCTTGTAGCAGCGCCTCCTCGGAGATCTATTGGGAAACTGATTATAACCACTCGGGCACCATCGATGCCCACGAGAT
GAGGACAGCCCTCAGGAAGGCAGGTTTCACCCTCAACAGCCAGGTGCAGCAGACCATTGCCCTGCGGTATGCGTGCAGCAAGCTCGGCAT
CAACTTTGACAGCTTCGTGGCTTGTATGATCCGCCTGGAGACCCTCTTCAAACTATTCAGCCTTCTGGACGAAGACAAGGATGGCATGGT
TCAGCTCTCTCTGGCCGAGTGGCTGTGCTGCGTGTTGGTCTGACCCGGGGTTTCGGACATCAGTGACACTCCCTGCCCCACTGCTTGCTT
CTTGTCACCCCTTCTCTACAATTTTGTGAACATTTATGCTCCAGTGGCATTCACTGGTTGTTCATACCTTTCTTGCCCTGGGTCTATTTC

>In-frame_ENST00000352989_ENST00000366872_215N_CLK3_chr15_74912566_+_CAPN8_chr1_223718212_length(amino acids)=215AA_start in transcript=25_stop in transcript=672
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSR
HRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVAC

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Fusion Gene PPI Analysis for CLK3-CAPN8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CLK3-CAPN8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CLK3-CAPN8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCAPN8C0007570Celiac Disease1CTD_human