FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CLK3-ZSWIM7 (FusionGDB2 ID:17235)

Fusion Gene Summary for CLK3-ZSWIM7

check button Fusion gene summary
Fusion gene informationFusion gene name: CLK3-ZSWIM7
Fusion gene ID: 17235
HgeneTgene
Gene symbol

CLK3

ZSWIM7

Gene ID

1198

125150

Gene nameCDC like kinase 3zinc finger SWIM-type containing 7
SynonymsPHCLK3|PHCLK3/152SWS1
Cytomap

15q24.1

17p12

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein kinase CLK3zinc finger SWIM domain-containing protein 7SWIM domain-containing and Srs2-interacting protein 1 homologSWIM-type zinc finger domain-containing protein 7
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000564353, ENST00000345005, 
ENST00000395066, ENST00000348245, 
ENST00000352989, 		ENST00000399277, 
ENST00000399280, ENST00000486655, 
ENST00000472495, 
Fusion gene scores* DoF score6 X 6 X 4=1444 X 3 X 4=48
# samples 64
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLK3 [Title/Abstract] AND ZSWIM7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLK3(74917357)-ZSWIM7(15881382), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLK3

GO:0006468

protein phosphorylation

9637771

HgeneCLK3

GO:0043484

regulation of RNA splicing

9637771


check buttonFusion gene breakpoints across CLK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZSWIM7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI859068CLK3chr15

74917357

+ZSWIM7chr17

15881382

-


Top

Fusion Gene ORF analysis for CLK3-ZSWIM7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000564353ENST00000399277CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
intron-5UTRENST00000564353ENST00000399280CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
intron-3UTRENST00000564353ENST00000486655CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
intron-3UTRENST00000564353ENST00000472495CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
In-frameENST00000345005ENST00000399277CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-5UTRENST00000345005ENST00000399280CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-3UTRENST00000345005ENST00000486655CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-3UTRENST00000345005ENST00000472495CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
In-frameENST00000395066ENST00000399277CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-5UTRENST00000395066ENST00000399280CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-3UTRENST00000395066ENST00000486655CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-3UTRENST00000395066ENST00000472495CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
3UTR-3CDSENST00000348245ENST00000399277CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
3UTR-5UTRENST00000348245ENST00000399280CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
3UTR-3UTRENST00000348245ENST00000486655CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
3UTR-3UTRENST00000348245ENST00000472495CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
In-frameENST00000352989ENST00000399277CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-5UTRENST00000352989ENST00000399280CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-3UTRENST00000352989ENST00000486655CLK3chr15

74917357

+ZSWIM7chr17

15881382

-
5CDS-3UTRENST00000352989ENST00000472495CLK3chr15

74917357

+ZSWIM7chr17

15881382

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000345005CLK3chr1574917357+ENST00000399277ZSWIM7chr1715881382-221470522726234
ENST00000395066CLK3chr1574917357+ENST00000399277ZSWIM7chr1715881382-306415552991576425
ENST00000352989CLK3chr1574917357+ENST00000399277ZSWIM7chr1715881382-211560625627200

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000345005ENST00000399277CLK3chr1574917357+ZSWIM7chr1715881382-0.0279264450.97207355
ENST00000395066ENST00000399277CLK3chr1574917357+ZSWIM7chr1715881382-0.14956210.8504379
ENST00000352989ENST00000399277CLK3chr1574917357+ZSWIM7chr1715881382-0.040467170.9595328

Top

Fusion Genomic Features for CLK3-ZSWIM7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CLK3-ZSWIM7


check button Go to

FGviewer for the breakpoints of chr15:74917357-chr17:15881382

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLK3chr15:74917357chr17:15881382ENST00000395066+613167_264364.6666666666667639.0Compositional biasNote=Arg-rich
HgeneCLK3chr15:74917357chr17:15881382ENST00000395066+613310_318364.6666666666667639.0Nucleotide bindingATP
TgeneZSWIM7chr15:74917357chr17:15881382ENST000003992770566_1140141.0Zinc fingerSWIM-type
TgeneZSWIM7chr15:74917357chr17:15881382ENST000004724950666_1140180.66666666666666Zinc fingerSWIM-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLK3chr15:74917357chr17:15881382ENST00000345005+613167_264216.66666666666666491.0Compositional biasNote=Arg-rich
HgeneCLK3chr15:74917357chr17:15881382ENST00000348245+512167_264184.33333333333334225.0Compositional biasNote=Arg-rich
HgeneCLK3chr15:74917357chr17:15881382ENST00000345005+613304_620216.66666666666666491.0DomainProtein kinase
HgeneCLK3chr15:74917357chr17:15881382ENST00000348245+512304_620184.33333333333334225.0DomainProtein kinase
HgeneCLK3chr15:74917357chr17:15881382ENST00000395066+613304_620364.6666666666667639.0DomainProtein kinase
HgeneCLK3chr15:74917357chr17:15881382ENST00000345005+613310_318216.66666666666666491.0Nucleotide bindingATP
HgeneCLK3chr15:74917357chr17:15881382ENST00000348245+512310_318184.33333333333334225.0Nucleotide bindingATP


Top

Fusion Gene Sequence for CLK3-ZSWIM7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000345005_ENST00000399277_BI859068_CLK3_chr15_74917357_+_ZSWIM7_chr17_15881382_length(transcript)=2214nt_BP=705nt
GGGGCACTGGTACCTCCAGGACCTGGAGTGTACTGGAAGAAATGGTGCAGTCCAGATGCATCACTGTAAGCGATACCGCTCCCCTGAACC
AGACCCGTACCTGAGCTACCGATGGAAGAGGAGGAGGTCCTACAGTCGGGAACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCC
TCCCCCACGAAGATCTCGGTCCAGAAGCCATGACCGCCTGCCCTACCAGAGGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTG
TGAAGAGCGGAGCCCATCCTTTGGAGAGGACTACTATGGACCTTCACGTTCTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCG
GACCCGCAAGCATGCCCACCACTGCCACAAACGCCGCACCAGGTCTTGTAGCAGCGCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAG
CAGCCGGAGTGTGGAAGATGACAAGGAGGGTCACCTGGTGTGCCGGATCGGCGATTGGCTCCAAGAGCGATATGAGATTGTGGGGAACCT
GGGTGAAGGCACCTTTGGCAAGGTGGTGGAGTGCTTGGACCATGCCAGAGGGAAGTCTCAGGTTGCCCTGAAGATCATCCGCAACGTGGG
CAAGTACCGGGAGGCTGCCCGGCTAGAAATCAACGTGCTCAAAAAAATCAAGGAGAAGGACAAAGAAAACAAGTTGGAGAAGAAACAAGA
AGCATAAAAGGTACAGATTGAGCATCATTCTTTCAAAATAGAATCCTGTCAAGAAATGCATTGAAAGCGTCATGATTCACATGGAAAAGA
GGTGAAATGGATCTTCAGACACTTCATGTTACTGTCCCTTTTCCCTCCAGGACTGCAGGAGGTGCTGTGGGTTGGAGCCGTGGGCTGTGG
AGGGTTTGTGTATGATGAGAAGCCCTGTACAGTCTTGTCAAGAAATACCCTGAGCCAGTCTCTGAGACGCTTCGGTAAAAAATGTCCCTG
GATGGAATCAAGATTTTAAATTCAAATAAAGCCTAATATCATGTTGTGTCCACATTATTTAGTCTTTTTTTTTTTCTTTTGAGATGGAGT
CTCACTTTGTCGCCCAGGCTGGGGTGCAGTGGCGTGATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCA
GCCTCCCGAGTAGCTGGGACTACAGGTACCCGCCACCATGCCCGGCTAAATTTTTGTATTTTTTTTTTAGTAGAGATGGGGTTTCACCGT
GTTAGCCAGGATGGTCTCCATCTCCTGACCTAGTGGTCTGCCCGCCTCGACCTCCCAAAGTGCTGGAATTACATGCATGAGCCACTGCGC
CTGACCCTATTTAGTCTTAAGTAACTAACTGAATTACTAGTAATTTTTAAAAGGTTGGAATGGTGGGCCAAACAGTAAGATGAAGTTTCG
ACGAGTAGGTCAGTTCTTTTCCTTGGGTCCAGGAAACTATTGAGCAGCAACAGAAGATCAGAGCAGAGATGTGGCTAAACAGTAGCAGGT
ATGAAAAGACTTAGAGGTTCTGGTTTCTGTAAGCTTCAAATATCTGTGATGCTTGTGCCAAAACAGCTTAAGTAGACTGTATTGTTTGAG
AGTTAGTATCGAGAACAAGGGAAGAACTGGTTTCACTCTGCACTTCTGATCTTTACAACAGGGCAATTGAAGGAACAGACTAAAAATCGT
GTCCTGGAAGGAAACTACAGGTACTACCAGGGATTTTCAGTCTGAAGAAGAAAAGACAAAATAGATGACAGAAGGAGTATTAGAAGGGAG
AGCGATGAGACTCAGTTGGACACCGAGAGAGCAAAGAAGCAATAATACGTGAAGATGAAAATGAAATCAATTTCAGCATAAGAAGACAAG
AACTTATGGTAAAGCTGCCCACAGCCAGAAGAGGATCCTAGAAGGACAGGAATTCCCTGTCTGCAGCATTTCATAAGCATGTAATATTGT
TGCAGGGATACTGCAGAAGGAGTTGAAGCAGTGGACAGACAGATGATATAGGTGATTTTACAGCCTAAGAAAGCCCTGTGCTTGTGCCCC
CAAAACATGAGGTGCTAGTGAATGAATGCTGGGGGAAAGCCCAGGGCCTAGGTGTTGCAATGTTCTGTGGTTGGCAGATGCTTTTTGTTT

>In-frame_ENST00000345005_ENST00000399277_BI859068_CLK3_chr15_74917357_+_ZSWIM7_chr17_15881382_length(amino acids)=234AA_start in transcript=22_stop in transcript=726
MECTGRNGAVQMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSF
GEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGK

--------------------------------------------------------------
>In-frame_ENST00000395066_ENST00000399277_BI859068_CLK3_chr15_74917357_+_ZSWIM7_chr17_15881382_length(transcript)=3064nt_BP=1555nt
AGTTTTCTCATCTGGAAAGTGGGGCCTCGTAATCCTGTCCGACCCGGCGCGGGACAGTAGGTGTCAGGGATTTTGGTGACCCCACGCTCG
AGGCCTCTGCAAAAGGGGGCTGTCCAGTGGCCCAGAGACGCAGCCGGCGGGGCTTTTGTCTAGCGGGGGAGTCTTAACTGAGAGGCCACG
CAGGCCGGCAGGAAGCCGCTCCACAGGAGGGGGCTCAAGGAGAGGGGATCTCCTCCCTCCAGACTCCGGCCCCGCCAGAGTAGCTCTAGG
GTATCTTCCCAGAAACTGCCCCGCACGCACTGGCGAGCTGGGAGCGCCACCACGGCTTTCAAAAAACCCGCACACACCAAGATAATAATG
TGTCGTTCGCTCGTTTCGCGCAAGCGGAGTCGCGTCCGCCTTCCCGAGCTCCGGCACACAGACCTCAGGCCGCTCTCGCGCTCTCCGGGG
CCCCGAGAACAATGCCCGTCCTCTCCGCGCGCAGGAGGGAGTTGGCGGACCACGCGGGGTCGGGGCGACGGAGCGGGCCCAGCCCCACGG
CCAGGTCGGGGCCCCACCTCTCGGCTCTGAGAGCCCAGCCGGCCCGGGCCGCGCACCTGTCAGGTCGGGGGACCTACGTGCGCCGCGACA
CGGCGGGAGGCGGGCCGGGCCAGGCTCGTCCCCTCGGCCCTCCCGGAACTAGTCTCCTAGGCCGCGGCGCCCGCCGGAGCGGAGAGGGCT
GGTGCCCCGGAGCCTTCGAGTCGGGGGCTAGAGCGGCCAGGCCTCCGAGCCGGGTCGAGCCGAGGCTGGCGACGGCTGCGTCACGCGAGG
GGGCGGGGCTGCCACGGGCGGAGGTCGCAGCCGGAAGCGGAAGAGGCGCTCGGAGCGGGGAGTGGGGCCTAGCTGCAGCCGGAGCCTGGG
AGACGATGCATCACTGTAAGCGATACCGCTCCCCTGAACCAGACCCGTACCTGAGCTACCGATGGAAGAGGAGGAGGTCCTACAGTCGGG
AACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCCTCCCCCACGAAGATCTCGGTCCAGAAGCCATGACCGCCTGCCCTACCAGA
GGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTGTGAAGAGCGGAGCCCATCCTTTGGAGAGGACTACTATGGACCTTCACGTT
CTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCGGACCCGCAAGCATGCCCACCACTGCCACAAACGCCGCACCAGGTCTTGTA
GCAGCGCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAGCAGCCGGAGTGTGGAAGATGACAAGGAGGGTCACCTGGTGTGCCGGATCG
GCGATTGGCTCCAAGAGCGATATGAGATTGTGGGGAACCTGGGTGAAGGCACCTTTGGCAAGGTGGTGGAGTGCTTGGACCATGCCAGAG
GGAAGTCTCAGGTTGCCCTGAAGATCATCCGCAACGTGGGCAAGTACCGGGAGGCTGCCCGGCTAGAAATCAACGTGCTCAAAAAAATCA
AGGAGAAGGACAAAGAAAACAAGTTGGAGAAGAAACAAGAAGCATAAAAGGTACAGATTGAGCATCATTCTTTCAAAATAGAATCCTGTC
AAGAAATGCATTGAAAGCGTCATGATTCACATGGAAAAGAGGTGAAATGGATCTTCAGACACTTCATGTTACTGTCCCTTTTCCCTCCAG
GACTGCAGGAGGTGCTGTGGGTTGGAGCCGTGGGCTGTGGAGGGTTTGTGTATGATGAGAAGCCCTGTACAGTCTTGTCAAGAAATACCC
TGAGCCAGTCTCTGAGACGCTTCGGTAAAAAATGTCCCTGGATGGAATCAAGATTTTAAATTCAAATAAAGCCTAATATCATGTTGTGTC
CACATTATTTAGTCTTTTTTTTTTTCTTTTGAGATGGAGTCTCACTTTGTCGCCCAGGCTGGGGTGCAGTGGCGTGATCTCAGCTCACTG
CAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTACCCGCCACCATGCCCGGCTAAA
TTTTTGTATTTTTTTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCCATCTCCTGACCTAGTGGTCTGCCCGCCTCGA
CCTCCCAAAGTGCTGGAATTACATGCATGAGCCACTGCGCCTGACCCTATTTAGTCTTAAGTAACTAACTGAATTACTAGTAATTTTTAA
AAGGTTGGAATGGTGGGCCAAACAGTAAGATGAAGTTTCGACGAGTAGGTCAGTTCTTTTCCTTGGGTCCAGGAAACTATTGAGCAGCAA
CAGAAGATCAGAGCAGAGATGTGGCTAAACAGTAGCAGGTATGAAAAGACTTAGAGGTTCTGGTTTCTGTAAGCTTCAAATATCTGTGAT
GCTTGTGCCAAAACAGCTTAAGTAGACTGTATTGTTTGAGAGTTAGTATCGAGAACAAGGGAAGAACTGGTTTCACTCTGCACTTCTGAT
CTTTACAACAGGGCAATTGAAGGAACAGACTAAAAATCGTGTCCTGGAAGGAAACTACAGGTACTACCAGGGATTTTCAGTCTGAAGAAG
AAAAGACAAAATAGATGACAGAAGGAGTATTAGAAGGGAGAGCGATGAGACTCAGTTGGACACCGAGAGAGCAAAGAAGCAATAATACGT
GAAGATGAAAATGAAATCAATTTCAGCATAAGAAGACAAGAACTTATGGTAAAGCTGCCCACAGCCAGAAGAGGATCCTAGAAGGACAGG
AATTCCCTGTCTGCAGCATTTCATAAGCATGTAATATTGTTGCAGGGATACTGCAGAAGGAGTTGAAGCAGTGGACAGACAGATGATATA
GGTGATTTTACAGCCTAAGAAAGCCCTGTGCTTGTGCCCCCAAAACATGAGGTGCTAGTGAATGAATGCTGGGGGAAAGCCCAGGGCCTA
GGTGTTGCAATGTTCTGTGGTTGGCAGATGCTTTTTGTTTTGTTAAAAAGTGCAACAGATAAAATTTATCAATACTTTTCTGCTACTCAG

>In-frame_ENST00000395066_ENST00000399277_BI859068_CLK3_chr15_74917357_+_ZSWIM7_chr17_15881382_length(amino acids)=425AA_start in transcript=299_stop in transcript=1576
MASWERHHGFQKTRTHQDNNVSFARFAQAESRPPSRAPAHRPQAALALSGAPRTMPVLSARRRELADHAGSGRRSGPSPTARSGPHLSAL
RAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVA
AGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSD
TYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEI

--------------------------------------------------------------
>In-frame_ENST00000352989_ENST00000399277_BI859068_CLK3_chr15_74917357_+_ZSWIM7_chr17_15881382_length(transcript)=2115nt_BP=606nt
AGCTGCAGCCGGAGCCTGGGAGACGATGCATCACTGTAAGCGATACCGCTCCCCTGAACCAGACCCGTACCTGAGCTACCGATGGAAGAG
GAGGAGGTCCTACAGTCGGGAACATGAAGGGAGACTGCGATACCCGTCCCGAAGGGAGCCTCCCCCACGAAGATCTCGGTCCAGAAGCCA
TGACCGCCTGCCCTACCAGAGGAGGTACCGGGAGCGCCGTGACAGCGATACATACCGGTGTGAAGAGCGGAGCCCATCCTTTGGAGAGGA
CTACTATGGACCTTCACGTTCTCGTCATCGTCGGCGATCGCGGGAGAGGGGGCCATACCGGACCCGCAAGCATGCCCACCACTGCCACAA
ACGCCGCACCAGGTCTTGTAGCAGCGCCTCCTCGAGAAGCCAACAGAGCAGTAAGCGCAGCAGCCGGAGTGTGGAAGATGACAAGGAGGG
TCACCTGGTGTGCCGGATCGGCGATTGGCTCCAAGAGCGATGGAAGTCTCAGGTTGCCCTGAAGATCATCCGCAACGTGGGCAAGTACCG
GGAGGCTGCCCGGCTAGAAATCAACGTGCTCAAAAAAATCAAGGAGAAGGACAAAGAAAACAAGTTGGAGAAGAAACAAGAAGCATAAAA
GGTACAGATTGAGCATCATTCTTTCAAAATAGAATCCTGTCAAGAAATGCATTGAAAGCGTCATGATTCACATGGAAAAGAGGTGAAATG
GATCTTCAGACACTTCATGTTACTGTCCCTTTTCCCTCCAGGACTGCAGGAGGTGCTGTGGGTTGGAGCCGTGGGCTGTGGAGGGTTTGT
GTATGATGAGAAGCCCTGTACAGTCTTGTCAAGAAATACCCTGAGCCAGTCTCTGAGACGCTTCGGTAAAAAATGTCCCTGGATGGAATC
AAGATTTTAAATTCAAATAAAGCCTAATATCATGTTGTGTCCACATTATTTAGTCTTTTTTTTTTTCTTTTGAGATGGAGTCTCACTTTG
TCGCCCAGGCTGGGGTGCAGTGGCGTGATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGA
GTAGCTGGGACTACAGGTACCCGCCACCATGCCCGGCTAAATTTTTGTATTTTTTTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAG
GATGGTCTCCATCTCCTGACCTAGTGGTCTGCCCGCCTCGACCTCCCAAAGTGCTGGAATTACATGCATGAGCCACTGCGCCTGACCCTA
TTTAGTCTTAAGTAACTAACTGAATTACTAGTAATTTTTAAAAGGTTGGAATGGTGGGCCAAACAGTAAGATGAAGTTTCGACGAGTAGG
TCAGTTCTTTTCCTTGGGTCCAGGAAACTATTGAGCAGCAACAGAAGATCAGAGCAGAGATGTGGCTAAACAGTAGCAGGTATGAAAAGA
CTTAGAGGTTCTGGTTTCTGTAAGCTTCAAATATCTGTGATGCTTGTGCCAAAACAGCTTAAGTAGACTGTATTGTTTGAGAGTTAGTAT
CGAGAACAAGGGAAGAACTGGTTTCACTCTGCACTTCTGATCTTTACAACAGGGCAATTGAAGGAACAGACTAAAAATCGTGTCCTGGAA
GGAAACTACAGGTACTACCAGGGATTTTCAGTCTGAAGAAGAAAAGACAAAATAGATGACAGAAGGAGTATTAGAAGGGAGAGCGATGAG
ACTCAGTTGGACACCGAGAGAGCAAAGAAGCAATAATACGTGAAGATGAAAATGAAATCAATTTCAGCATAAGAAGACAAGAACTTATGG
TAAAGCTGCCCACAGCCAGAAGAGGATCCTAGAAGGACAGGAATTCCCTGTCTGCAGCATTTCATAAGCATGTAATATTGTTGCAGGGAT
ACTGCAGAAGGAGTTGAAGCAGTGGACAGACAGATGATATAGGTGATTTTACAGCCTAAGAAAGCCCTGTGCTTGTGCCCCCAAAACATG
AGGTGCTAGTGAATGAATGCTGGGGGAAAGCCCAGGGCCTAGGTGTTGCAATGTTCTGTGGTTGGCAGATGCTTTTTGTTTTGTTAAAAA

>In-frame_ENST00000352989_ENST00000399277_BI859068_CLK3_chr15_74917357_+_ZSWIM7_chr17_15881382_length(amino acids)=200AA_start in transcript=25_stop in transcript=627
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSR
HRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERWKSQVALKIIRNVGKYREAARLEIN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CLK3-ZSWIM7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CLK3-ZSWIM7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CLK3-ZSWIM7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource