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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CLTC-IGFBP7 (FusionGDB2 ID:17414) |
Fusion Gene Summary for CLTC-IGFBP7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLTC-IGFBP7 | Fusion gene ID: 17414 | Hgene | Tgene | Gene symbol | CLTC | IGFBP7 | Gene ID | 1213 | 3490 |
| Gene name | clathrin heavy chain | insulin like growth factor binding protein 7 | |
| Synonyms | CHC|CHC17|CLH-17|CLTCL2|Hc|MRD56 | AGM|FSTL2|IBP-7|IGFBP-7|IGFBP-7v|IGFBPRP1|MAC25|PSF|RAMSVPS|TAF | |
| Cytomap | 17q23.1 | 4q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | clathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2 | insulin-like growth factor-binding protein 7IGF-binding protein 7IGFBP-rP1PGI2-stimulating factorangiomodulinprostacyclin-stimulating factortumor-derived adhesion factor | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q00610 | Q16270 | |
| Ensembl transtripts involved in fusion gene | ENST00000393043, ENST00000269122, ENST00000579456, ENST00000579815, | ENST00000295666, ENST00000537922, ENST00000512512, | |
| Fusion gene scores | * DoF score | 27 X 40 X 17=18360 | 9 X 8 X 4=288 |
| # samples | 84 | 9 | |
| ** MAII score | log2(84/18360*10)=-4.45003292063505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CLTC [Title/Abstract] AND IGFBP7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CLTC(57697534)-IGFBP7(57899477), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CLTC | GO:1900126 | negative regulation of hyaluronan biosynthetic process | 24251095 |
| Tgene | IGFBP7 | GO:0007155 | cell adhesion | 8117260 |
| Fusion gene breakpoints across CLTC (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across IGFBP7 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | 61N | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - |
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Fusion Gene ORF analysis for CLTC-IGFBP7 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000393043 | ENST00000295666 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - |
| In-frame | ENST00000393043 | ENST00000537922 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - |
| 5CDS-5UTR | ENST00000393043 | ENST00000512512 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - |
| In-frame | ENST00000269122 | ENST00000295666 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - |
| In-frame | ENST00000269122 | ENST00000537922 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - |
| 5CDS-5UTR | ENST00000269122 | ENST00000512512 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - |
| In-frame | ENST00000579456 | ENST00000295666 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - |
| In-frame | ENST00000579456 | ENST00000537922 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - |
| 5CDS-5UTR | ENST00000579456 | ENST00000512512 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - |
| intron-3CDS | ENST00000579815 | ENST00000295666 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - |
| intron-3CDS | ENST00000579815 | ENST00000537922 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - |
| intron-5UTR | ENST00000579815 | ENST00000512512 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000393043 | CLTC | chr17 | 57697534 | + | ENST00000295666 | IGFBP7 | chr4 | 57899477 | - | 1124 | 316 | 514 | 35 | 159 |
| ENST00000393043 | CLTC | chr17 | 57697534 | + | ENST00000537922 | IGFBP7 | chr4 | 57899477 | - | 948 | 316 | 514 | 35 | 159 |
| ENST00000269122 | CLTC | chr17 | 57697534 | + | ENST00000295666 | IGFBP7 | chr4 | 57899477 | - | 1124 | 316 | 514 | 35 | 159 |
| ENST00000269122 | CLTC | chr17 | 57697534 | + | ENST00000537922 | IGFBP7 | chr4 | 57899477 | - | 948 | 316 | 514 | 35 | 159 |
| ENST00000579456 | CLTC | chr17 | 57697534 | + | ENST00000295666 | IGFBP7 | chr4 | 57899477 | - | 1050 | 242 | 440 | 0 | 147 |
| ENST00000579456 | CLTC | chr17 | 57697534 | + | ENST00000537922 | IGFBP7 | chr4 | 57899477 | - | 874 | 242 | 440 | 0 | 147 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000393043 | ENST00000295666 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - | 0.06983841 | 0.93016154 |
| ENST00000393043 | ENST00000537922 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - | 0.065351166 | 0.9346489 |
| ENST00000269122 | ENST00000295666 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - | 0.06983841 | 0.93016154 |
| ENST00000269122 | ENST00000537922 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - | 0.065351166 | 0.9346489 |
| ENST00000579456 | ENST00000295666 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - | 0.094448656 | 0.9055513 |
| ENST00000579456 | ENST00000537922 | CLTC | chr17 | 57697534 | + | IGFBP7 | chr4 | 57899477 | - | 0.036367647 | 0.9636323 |
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Fusion Genomic Features for CLTC-IGFBP7 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CLTC-IGFBP7 |
| Go to FGviewer for the breakpoints of chr17:57697534-chr4:57899477 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLTC | IGFBP7 |
| FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}. | FUNCTION: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. {ECO:0000269|PubMed:8117260, ECO:0000269|PubMed:8939990}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 108_149 | 14.0 | 1676.0 | Region | Note=WD40-like repeat 3 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 1213_1522 | 14.0 | 1676.0 | Region | Involved in binding clathrin light chain |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 150_195 | 14.0 | 1676.0 | Region | Note=WD40-like repeat 4 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 1550_1675 | 14.0 | 1676.0 | Region | Trimerization |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 196_257 | 14.0 | 1676.0 | Region | Note=WD40-like repeat 5 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 24_67 | 14.0 | 1676.0 | Region | Note=WD40-like repeat 1 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 258_301 | 14.0 | 1676.0 | Region | Note=WD40-like repeat 6 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 2_479 | 14.0 | 1676.0 | Region | Note=Globular terminal domain |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 302_330 | 14.0 | 1676.0 | Region | Note=WD40-like repeat 7 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 449_465 | 14.0 | 1676.0 | Region | Binding site for the uncoating ATPase%2C involved in lattice disassembly |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 480_523 | 14.0 | 1676.0 | Region | Note=Flexible linker |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 524_1675 | 14.0 | 1676.0 | Region | Note=Heavy chain arm |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 524_634 | 14.0 | 1676.0 | Region | Note=Distal segment |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 639_1675 | 14.0 | 1676.0 | Region | Note=Proximal segment |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 68_107 | 14.0 | 1676.0 | Region | Note=WD40-like repeat 2 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 108_149 | 14.0 | 1640.0 | Region | Note=WD40-like repeat 3 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 1213_1522 | 14.0 | 1640.0 | Region | Involved in binding clathrin light chain |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 150_195 | 14.0 | 1640.0 | Region | Note=WD40-like repeat 4 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 1550_1675 | 14.0 | 1640.0 | Region | Trimerization |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 196_257 | 14.0 | 1640.0 | Region | Note=WD40-like repeat 5 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 24_67 | 14.0 | 1640.0 | Region | Note=WD40-like repeat 1 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 258_301 | 14.0 | 1640.0 | Region | Note=WD40-like repeat 6 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 2_479 | 14.0 | 1640.0 | Region | Note=Globular terminal domain |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 302_330 | 14.0 | 1640.0 | Region | Note=WD40-like repeat 7 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 449_465 | 14.0 | 1640.0 | Region | Binding site for the uncoating ATPase%2C involved in lattice disassembly |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 480_523 | 14.0 | 1640.0 | Region | Note=Flexible linker |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 524_1675 | 14.0 | 1640.0 | Region | Note=Heavy chain arm |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 524_634 | 14.0 | 1640.0 | Region | Note=Distal segment |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 639_1675 | 14.0 | 1640.0 | Region | Note=Proximal segment |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 68_107 | 14.0 | 1640.0 | Region | Note=WD40-like repeat 2 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 1128_1269 | 14.0 | 1676.0 | Repeat | CHCR 5 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 1274_1420 | 14.0 | 1676.0 | Repeat | CHCR 6 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 1423_1566 | 14.0 | 1676.0 | Repeat | CHCR 7 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 537_683 | 14.0 | 1676.0 | Repeat | CHCR 1 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 686_828 | 14.0 | 1676.0 | Repeat | CHCR 2 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 833_972 | 14.0 | 1676.0 | Repeat | CHCR 3 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000269122 | + | 1 | 32 | 979_1124 | 14.0 | 1676.0 | Repeat | CHCR 4 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 1128_1269 | 14.0 | 1640.0 | Repeat | CHCR 5 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 1274_1420 | 14.0 | 1640.0 | Repeat | CHCR 6 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 1423_1566 | 14.0 | 1640.0 | Repeat | CHCR 7 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 537_683 | 14.0 | 1640.0 | Repeat | CHCR 1 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 686_828 | 14.0 | 1640.0 | Repeat | CHCR 2 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 833_972 | 14.0 | 1640.0 | Repeat | CHCR 3 |
| Hgene | CLTC | chr17:57697534 | chr4:57899477 | ENST00000393043 | + | 1 | 31 | 979_1124 | 14.0 | 1640.0 | Repeat | CHCR 4 |
| Tgene | IGFBP7 | chr17:57697534 | chr4:57899477 | ENST00000295666 | 1 | 5 | 105_158 | 195.0 | 283.0 | Domain | Kazal-like | |
| Tgene | IGFBP7 | chr17:57697534 | chr4:57899477 | ENST00000295666 | 1 | 5 | 160_264 | 195.0 | 283.0 | Domain | Note=Ig-like C2-type | |
| Tgene | IGFBP7 | chr17:57697534 | chr4:57899477 | ENST00000295666 | 1 | 5 | 28_106 | 195.0 | 283.0 | Domain | IGFBP N-terminal | |
| Tgene | IGFBP7 | chr17:57697534 | chr4:57899477 | ENST00000537922 | 1 | 4 | 105_158 | 195.0 | 280.0 | Domain | Kazal-like | |
| Tgene | IGFBP7 | chr17:57697534 | chr4:57899477 | ENST00000537922 | 1 | 4 | 160_264 | 195.0 | 280.0 | Domain | Note=Ig-like C2-type | |
| Tgene | IGFBP7 | chr17:57697534 | chr4:57899477 | ENST00000537922 | 1 | 4 | 28_106 | 195.0 | 280.0 | Domain | IGFBP N-terminal |
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Fusion Gene Sequence for CLTC-IGFBP7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000393043_ENST00000295666_61N_CLTC_chr17_57697534_+_IGFBP7_chr4_57899477_length(transcript)=1124nt_BP=316nt GGCGGAGTTCTGTCGCCGGGATCCTTCCGCTGGGCTCAGCCGTTTCCGGAGTCTGCGCTGCGCCCGGTTCCGCCATTGCGGCTCTCCTGG CCCCTGGAGCCTCCGCCCCCGACCCGAGCTCTTTCGTCTGCCTGCCAGTTTCCTGCGTCCCCGGAGAGGATCCTGCTGAGCCCAGCCTCC CCCCTCCCCTTCTCCTCCTCTCCCTTGGAGAGCCCGGGCAGCCACTGCCCCGCAGCCCCAGTGACAGGAGGAGACCATAACCCCCGACAG CGCCATGGCCCAGATTCTGCCAATTCGTTTTCAGGAGCATCTCCAGGTAAAAAGGGGTCACTATGGAGTTCAAAGGACAGAACTCCTGCC TGGTGACCGGGACAACCTGGCCATTCAGACCCGGGGTGGCCCAGAAAAGCATGAAGTAACTGGCTGGGTGCTGGTATCTCCTCTAAGTAA GGAAGATGCTGGAGAATATGAGTGCCATGCATCCAATTCCCAAGGACAGGCTTCAGCATCAGCAAAAATTACAGTGGTTGATGCCTTACA TGAAATACCAGTGAAAAAAGGTGAAGGTGCCGAGCTATAAACCTCCAGAATATTATTAGTCTGCATGGTTAAAAGTAGTCATGGATAACT ACATTACCTGTTCTTGCCTAATAAGTTTCTTTTAATCCAATCCACTAACACTTTAGTTATATTCACTGGTTTTACACAGAGAAATACAAA ATAAAGATCACACATCAAGACTATCTACAAAAATTTATTATATATTTACAGAAGAAAAGCATGCATATCATTAAACAAATAAAATACTTT TTATCACAACACAGTACATATTTGTCATTTTTAAAAAGCCACACAATAGAAACAAGACACCAAGATATTTAATTATCTTGTTGACTCCTG TAAAATAGCTAAACACTCATCATTCGCGGTGCAATACTCATAGACATAAGTTCCTGAAACAATAGTTTGCATGCGTAAGGCATTCGCACC AAAGAAATCTGAAAAGAAAAAACAAATGGTAATTAGCAGAATTGTATTGAAGTGACCCCACTTCTCTACCCCAGAAAAAGACAAAGATCT >In-frame_ENST00000393043_ENST00000295666_61N_CLTC_chr17_57697534_+_IGFBP7_chr4_57899477_length(amino acids)=159AA_start in transcript=514_stop in transcript=35 MLMLKPVLGNWMHGTHILQHLPYLEEIPAPSQLLHAFLGHPGSEWPGCPGHQAGVLSFELHSDPFLPGDAPENELAESGPWRCRGLWSPP -------------------------------------------------------------- >In-frame_ENST00000393043_ENST00000537922_61N_CLTC_chr17_57697534_+_IGFBP7_chr4_57899477_length(transcript)=948nt_BP=316nt GGCGGAGTTCTGTCGCCGGGATCCTTCCGCTGGGCTCAGCCGTTTCCGGAGTCTGCGCTGCGCCCGGTTCCGCCATTGCGGCTCTCCTGG CCCCTGGAGCCTCCGCCCCCGACCCGAGCTCTTTCGTCTGCCTGCCAGTTTCCTGCGTCCCCGGAGAGGATCCTGCTGAGCCCAGCCTCC CCCCTCCCCTTCTCCTCCTCTCCCTTGGAGAGCCCGGGCAGCCACTGCCCCGCAGCCCCAGTGACAGGAGGAGACCATAACCCCCGACAG CGCCATGGCCCAGATTCTGCCAATTCGTTTTCAGGAGCATCTCCAGGTAAAAAGGGGTCACTATGGAGTTCAAAGGACAGAACTCCTGCC TGGTGACCGGGACAACCTGGCCATTCAGACCCGGGGTGGCCCAGAAAAGCATGAAGTAACTGGCTGGGTGCTGGTATCTCCTCTAAGTAA GGAAGATGCTGGAGAATATGAGTGCCATGCATCCAATTCCCAAGGACAGGCTTCAGCATCAGCAAAAATTACAGTGGTTGATGCCTTACA TGAAATACCAGTGAAAAAAGGTACACAATAAATCTCACAGCCATTTAAAAATGACTAGTACATTTGCTTTAAAAAGAACAGAACTAAGTA TGAAAGTATCAGACGTAGCTATTGATGAAATTCTGTAGTTAGCAACCCATAAGGGCATTAAGTATGCCATTAAAATGTACAGCATGAGAC TCCAAAAGATTATCTGGATGGGTGACTGAACATCGTTATTATGACTTAGATGCTTTTACCTTATCTAACATGTAAGAGTCAAAATCAAAC TTGCCTGGAATGGCTTCTATTTCCCATAGCTTTCTACCTATCTACTTGGCATTTTCCCTTTGTGTTGTGACTATTAAATTCCTATTTAAA >In-frame_ENST00000393043_ENST00000537922_61N_CLTC_chr17_57697534_+_IGFBP7_chr4_57899477_length(amino acids)=159AA_start in transcript=514_stop in transcript=35 MLMLKPVLGNWMHGTHILQHLPYLEEIPAPSQLLHAFLGHPGSEWPGCPGHQAGVLSFELHSDPFLPGDAPENELAESGPWRCRGLWSPP -------------------------------------------------------------- >In-frame_ENST00000269122_ENST00000295666_61N_CLTC_chr17_57697534_+_IGFBP7_chr4_57899477_length(transcript)=1124nt_BP=316nt GGCGGAGTTCTGTCGCCGGGATCCTTCCGCTGGGCTCAGCCGTTTCCGGAGTCTGCGCTGCGCCCGGTTCCGCCATTGCGGCTCTCCTGG CCCCTGGAGCCTCCGCCCCCGACCCGAGCTCTTTCGTCTGCCTGCCAGTTTCCTGCGTCCCCGGAGAGGATCCTGCTGAGCCCAGCCTCC CCCCTCCCCTTCTCCTCCTCTCCCTTGGAGAGCCCGGGCAGCCACTGCCCCGCAGCCCCAGTGACAGGAGGAGACCATAACCCCCGACAG CGCCATGGCCCAGATTCTGCCAATTCGTTTTCAGGAGCATCTCCAGGTAAAAAGGGGTCACTATGGAGTTCAAAGGACAGAACTCCTGCC TGGTGACCGGGACAACCTGGCCATTCAGACCCGGGGTGGCCCAGAAAAGCATGAAGTAACTGGCTGGGTGCTGGTATCTCCTCTAAGTAA GGAAGATGCTGGAGAATATGAGTGCCATGCATCCAATTCCCAAGGACAGGCTTCAGCATCAGCAAAAATTACAGTGGTTGATGCCTTACA TGAAATACCAGTGAAAAAAGGTGAAGGTGCCGAGCTATAAACCTCCAGAATATTATTAGTCTGCATGGTTAAAAGTAGTCATGGATAACT ACATTACCTGTTCTTGCCTAATAAGTTTCTTTTAATCCAATCCACTAACACTTTAGTTATATTCACTGGTTTTACACAGAGAAATACAAA ATAAAGATCACACATCAAGACTATCTACAAAAATTTATTATATATTTACAGAAGAAAAGCATGCATATCATTAAACAAATAAAATACTTT TTATCACAACACAGTACATATTTGTCATTTTTAAAAAGCCACACAATAGAAACAAGACACCAAGATATTTAATTATCTTGTTGACTCCTG TAAAATAGCTAAACACTCATCATTCGCGGTGCAATACTCATAGACATAAGTTCCTGAAACAATAGTTTGCATGCGTAAGGCATTCGCACC AAAGAAATCTGAAAAGAAAAAACAAATGGTAATTAGCAGAATTGTATTGAAGTGACCCCACTTCTCTACCCCAGAAAAAGACAAAGATCT >In-frame_ENST00000269122_ENST00000295666_61N_CLTC_chr17_57697534_+_IGFBP7_chr4_57899477_length(amino acids)=159AA_start in transcript=514_stop in transcript=35 MLMLKPVLGNWMHGTHILQHLPYLEEIPAPSQLLHAFLGHPGSEWPGCPGHQAGVLSFELHSDPFLPGDAPENELAESGPWRCRGLWSPP -------------------------------------------------------------- >In-frame_ENST00000269122_ENST00000537922_61N_CLTC_chr17_57697534_+_IGFBP7_chr4_57899477_length(transcript)=948nt_BP=316nt GGCGGAGTTCTGTCGCCGGGATCCTTCCGCTGGGCTCAGCCGTTTCCGGAGTCTGCGCTGCGCCCGGTTCCGCCATTGCGGCTCTCCTGG CCCCTGGAGCCTCCGCCCCCGACCCGAGCTCTTTCGTCTGCCTGCCAGTTTCCTGCGTCCCCGGAGAGGATCCTGCTGAGCCCAGCCTCC CCCCTCCCCTTCTCCTCCTCTCCCTTGGAGAGCCCGGGCAGCCACTGCCCCGCAGCCCCAGTGACAGGAGGAGACCATAACCCCCGACAG CGCCATGGCCCAGATTCTGCCAATTCGTTTTCAGGAGCATCTCCAGGTAAAAAGGGGTCACTATGGAGTTCAAAGGACAGAACTCCTGCC TGGTGACCGGGACAACCTGGCCATTCAGACCCGGGGTGGCCCAGAAAAGCATGAAGTAACTGGCTGGGTGCTGGTATCTCCTCTAAGTAA GGAAGATGCTGGAGAATATGAGTGCCATGCATCCAATTCCCAAGGACAGGCTTCAGCATCAGCAAAAATTACAGTGGTTGATGCCTTACA TGAAATACCAGTGAAAAAAGGTACACAATAAATCTCACAGCCATTTAAAAATGACTAGTACATTTGCTTTAAAAAGAACAGAACTAAGTA TGAAAGTATCAGACGTAGCTATTGATGAAATTCTGTAGTTAGCAACCCATAAGGGCATTAAGTATGCCATTAAAATGTACAGCATGAGAC TCCAAAAGATTATCTGGATGGGTGACTGAACATCGTTATTATGACTTAGATGCTTTTACCTTATCTAACATGTAAGAGTCAAAATCAAAC TTGCCTGGAATGGCTTCTATTTCCCATAGCTTTCTACCTATCTACTTGGCATTTTCCCTTTGTGTTGTGACTATTAAATTCCTATTTAAA >In-frame_ENST00000269122_ENST00000537922_61N_CLTC_chr17_57697534_+_IGFBP7_chr4_57899477_length(amino acids)=159AA_start in transcript=514_stop in transcript=35 MLMLKPVLGNWMHGTHILQHLPYLEEIPAPSQLLHAFLGHPGSEWPGCPGHQAGVLSFELHSDPFLPGDAPENELAESGPWRCRGLWSPP -------------------------------------------------------------- >In-frame_ENST00000579456_ENST00000295666_61N_CLTC_chr17_57697534_+_IGFBP7_chr4_57899477_length(transcript)=1050nt_BP=242nt ATTGCGGCTCTCCTGGCCCCTGGAGCCTCCGCCCCCGACCCGAGCTCTTTCGTCTGCCTGCCAGTTTCCTGCGTCCCCGGAGAGGATCCT GCTGAGCCCAGCCTCCCCCCTCCCCTTCTCCTCCTCTCCCTTGGAGAGCCCGGGCAGCCACTGCCCCGCAGCCCCAGTGACAGGAGGAGA CCATAACCCCCGACAGCGCCATGGCCCAGATTCTGCCAATTCGTTTTCAGGAGCATCTCCAGGTAAAAAGGGGTCACTATGGAGTTCAAA GGACAGAACTCCTGCCTGGTGACCGGGACAACCTGGCCATTCAGACCCGGGGTGGCCCAGAAAAGCATGAAGTAACTGGCTGGGTGCTGG TATCTCCTCTAAGTAAGGAAGATGCTGGAGAATATGAGTGCCATGCATCCAATTCCCAAGGACAGGCTTCAGCATCAGCAAAAATTACAG TGGTTGATGCCTTACATGAAATACCAGTGAAAAAAGGTGAAGGTGCCGAGCTATAAACCTCCAGAATATTATTAGTCTGCATGGTTAAAA GTAGTCATGGATAACTACATTACCTGTTCTTGCCTAATAAGTTTCTTTTAATCCAATCCACTAACACTTTAGTTATATTCACTGGTTTTA CACAGAGAAATACAAAATAAAGATCACACATCAAGACTATCTACAAAAATTTATTATATATTTACAGAAGAAAAGCATGCATATCATTAA ACAAATAAAATACTTTTTATCACAACACAGTACATATTTGTCATTTTTAAAAAGCCACACAATAGAAACAAGACACCAAGATATTTAATT ATCTTGTTGACTCCTGTAAAATAGCTAAACACTCATCATTCGCGGTGCAATACTCATAGACATAAGTTCCTGAAACAATAGTTTGCATGC GTAAGGCATTCGCACCAAAGAAATCTGAAAAGAAAAAACAAATGGTAATTAGCAGAATTGTATTGAAGTGACCCCACTTCTCTACCCCAG >In-frame_ENST00000579456_ENST00000295666_61N_CLTC_chr17_57697534_+_IGFBP7_chr4_57899477_length(amino acids)=147AA_start in transcript=440_stop in transcript=0 MLMLKPVLGNWMHGTHILQHLPYLEEIPAPSQLLHAFLGHPGSEWPGCPGHQAGVLSFELHSDPFLPGDAPENELAESGPWRCRGLWSPP -------------------------------------------------------------- >In-frame_ENST00000579456_ENST00000537922_61N_CLTC_chr17_57697534_+_IGFBP7_chr4_57899477_length(transcript)=874nt_BP=242nt ATTGCGGCTCTCCTGGCCCCTGGAGCCTCCGCCCCCGACCCGAGCTCTTTCGTCTGCCTGCCAGTTTCCTGCGTCCCCGGAGAGGATCCT GCTGAGCCCAGCCTCCCCCCTCCCCTTCTCCTCCTCTCCCTTGGAGAGCCCGGGCAGCCACTGCCCCGCAGCCCCAGTGACAGGAGGAGA CCATAACCCCCGACAGCGCCATGGCCCAGATTCTGCCAATTCGTTTTCAGGAGCATCTCCAGGTAAAAAGGGGTCACTATGGAGTTCAAA GGACAGAACTCCTGCCTGGTGACCGGGACAACCTGGCCATTCAGACCCGGGGTGGCCCAGAAAAGCATGAAGTAACTGGCTGGGTGCTGG TATCTCCTCTAAGTAAGGAAGATGCTGGAGAATATGAGTGCCATGCATCCAATTCCCAAGGACAGGCTTCAGCATCAGCAAAAATTACAG TGGTTGATGCCTTACATGAAATACCAGTGAAAAAAGGTACACAATAAATCTCACAGCCATTTAAAAATGACTAGTACATTTGCTTTAAAA AGAACAGAACTAAGTATGAAAGTATCAGACGTAGCTATTGATGAAATTCTGTAGTTAGCAACCCATAAGGGCATTAAGTATGCCATTAAA ATGTACAGCATGAGACTCCAAAAGATTATCTGGATGGGTGACTGAACATCGTTATTATGACTTAGATGCTTTTACCTTATCTAACATGTA AGAGTCAAAATCAAACTTGCCTGGAATGGCTTCTATTTCCCATAGCTTTCTACCTATCTACTTGGCATTTTCCCTTTGTGTTGTGACTAT >In-frame_ENST00000579456_ENST00000537922_61N_CLTC_chr17_57697534_+_IGFBP7_chr4_57899477_length(amino acids)=147AA_start in transcript=440_stop in transcript=0 MLMLKPVLGNWMHGTHILQHLPYLEEIPAPSQLLHAFLGHPGSEWPGCPGHQAGVLSFELHSDPFLPGDAPENELAESGPWRCRGLWSPP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CLTC-IGFBP7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CLTC-IGFBP7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | IGFBP7 | Q16270 | DB00071 | Insulin pork | Biotech | Approved | |
| Tgene | IGFBP7 | Q16270 | DB00071 | Insulin pork | Biotech | Approved | |
| Tgene | IGFBP7 | Q16270 | DB00071 | Insulin pork | Biotech | Approved |
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Related Diseases for CLTC-IGFBP7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CLTC | C4518356 | MiT family translocation renal cell carcinoma | 2 | ORPHANET |
| Hgene | CLTC | C4693389 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 56 | 2 | GENOMICS_ENGLAND;UNIPROT |
| Hgene | CLTC | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
| Hgene | CLTC | C0334121 | Inflammatory Myofibroblastic Tumor | 1 | ORPHANET |
| Tgene | IGFBP7 | C3280205 | RETINAL ARTERIAL MACROANEURYSM WITH SUPRAVALVULAR PULMONIC STENOSIS | 2 | GENOMICS_ENGLAND;ORPHANET |
| Tgene | IGFBP7 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
| Tgene | IGFBP7 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | IGFBP7 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
| Tgene | IGFBP7 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | IGFBP7 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | IGFBP7 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| Tgene | IGFBP7 | C0678222 | Breast Carcinoma | 1 | CTD_human |
| Tgene | IGFBP7 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
| Tgene | IGFBP7 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | IGFBP7 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
| Tgene | IGFBP7 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
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