FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CLTC-RPS6KB1 (FusionGDB2 ID:17423)

Fusion Gene Summary for CLTC-RPS6KB1

check button Fusion gene summary
Fusion gene informationFusion gene name: CLTC-RPS6KB1
Fusion gene ID: 17423
HgeneTgene
Gene symbol

CLTC

RPS6KB1

Gene ID

1213

6198

Gene nameclathrin heavy chainribosomal protein S6 kinase B1
SynonymsCHC|CHC17|CLH-17|CLTCL2|Hc|MRD56PS6K|S6K|S6K-beta-1|S6K1|STK14A|p70 S6KA|p70(S6K)-alpha|p70-S6K|p70-alpha
Cytomap

17q23.1

17q23.1

Type of geneprotein-codingprotein-coding
Descriptionclathrin heavy chain 1clathrin heavy chain on chromosome 17clathrin, heavy polypeptide (Hc)clathrin, heavy polypeptide-like 2ribosomal protein S6 kinase beta-1p70 S6 kinase, alpharibosomal protein S6 kinase Iribosomal protein S6 kinase, 70kDa, polypeptide 1serine/threonine kinase 14 alphaserine/threonine-protein kinase 14A
Modification date2020031320200313
UniProtAcc

Q00610

.
Ensembl transtripts involved in fusion geneENST00000393043, ENST00000269122, 
ENST00000579456, ENST00000579815, 
ENST00000443572, ENST00000406116, 
ENST00000225577, ENST00000393021, 
ENST00000587061, 
Fusion gene scores* DoF score27 X 40 X 17=1836010 X 6 X 7=420
# samples 8412
** MAII scorelog2(84/18360*10)=-4.45003292063505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/420*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLTC [Title/Abstract] AND RPS6KB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLTC(57746301)-RPS6KB1(57987923), # samples:1
RPS6KB1(57970686)-CLTC(57762417), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLTC

GO:1900126

negative regulation of hyaluronan biosynthetic process

24251095

TgeneRPS6KB1

GO:0031667

response to nutrient levels

29750193

TgeneRPS6KB1

GO:0031929

TOR signaling

12150926

TgeneRPS6KB1

GO:0071363

cellular response to growth factor stimulus

17936702


check buttonFusion gene breakpoints across CLTC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RPS6KB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A62V-01ACLTCchr17

57746301

+RPS6KB1chr17

57987923

+


Top

Fusion Gene ORF analysis for CLTC-RPS6KB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000393043ENST00000443572CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
In-frameENST00000393043ENST00000406116CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
In-frameENST00000393043ENST00000225577CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
5CDS-5UTRENST00000393043ENST00000393021CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
5CDS-intronENST00000393043ENST00000587061CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
In-frameENST00000269122ENST00000443572CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
In-frameENST00000269122ENST00000406116CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
In-frameENST00000269122ENST00000225577CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
5CDS-5UTRENST00000269122ENST00000393021CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
5CDS-intronENST00000269122ENST00000587061CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
intron-3CDSENST00000579456ENST00000443572CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
intron-3CDSENST00000579456ENST00000406116CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
intron-3CDSENST00000579456ENST00000225577CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
intron-5UTRENST00000579456ENST00000393021CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
intron-intronENST00000579456ENST00000587061CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
intron-3CDSENST00000579815ENST00000443572CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
intron-3CDSENST00000579815ENST00000406116CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
intron-3CDSENST00000579815ENST00000225577CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
intron-5UTRENST00000579815ENST00000393021CLTCchr17

57746301

+RPS6KB1chr17

57987923

+
intron-intronENST00000579815ENST00000587061CLTCchr17

57746301

+RPS6KB1chr17

57987923

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393043CLTCchr1757746301+ENST00000443572RPS6KB1chr1757987923+4283256627439331219
ENST00000393043CLTCchr1757746301+ENST00000406116RPS6KB1chr1757987923+4367256627437801168
ENST00000393043CLTCchr1757746301+ENST00000225577RPS6KB1chr1757987923+7779256627440021242
ENST00000269122CLTCchr1757746301+ENST00000443572RPS6KB1chr1757987923+4283256627439331219
ENST00000269122CLTCchr1757746301+ENST00000406116RPS6KB1chr1757987923+4367256627437801168
ENST00000269122CLTCchr1757746301+ENST00000225577RPS6KB1chr1757987923+7779256627440021242

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393043ENST00000443572CLTCchr1757746301+RPS6KB1chr1757987923+0.0004470810.9995529
ENST00000393043ENST00000406116CLTCchr1757746301+RPS6KB1chr1757987923+0.0002848330.99971515
ENST00000393043ENST00000225577CLTCchr1757746301+RPS6KB1chr1757987923+8.58E-050.9999143
ENST00000269122ENST00000443572CLTCchr1757746301+RPS6KB1chr1757987923+0.0004470810.9995529
ENST00000269122ENST00000406116CLTCchr1757746301+RPS6KB1chr1757987923+0.0002848330.99971515
ENST00000269122ENST00000225577CLTCchr1757746301+RPS6KB1chr1757987923+8.58E-050.9999143

Top

Fusion Genomic Features for CLTC-RPS6KB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CLTCchr1757746301+RPS6KB1chr1757987922+2.88E-111
CLTCchr1757746301+RPS6KB1chr1757987922+2.88E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CLTC-RPS6KB1


check button Go to

FGviewer for the breakpoints of chr17:57746301-chr17:57987923

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLTC

Q00610

.
FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). {ECO:0000269|PubMed:15858577, ECO:0000269|PubMed:16968737, ECO:0000269|PubMed:20639872, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+1432108_149764.01676.0RegionNote=WD40-like repeat 3
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+1432150_195764.01676.0RegionNote=WD40-like repeat 4
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+1432196_257764.01676.0RegionNote=WD40-like repeat 5
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+143224_67764.01676.0RegionNote=WD40-like repeat 1
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+1432258_301764.01676.0RegionNote=WD40-like repeat 6
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+14322_479764.01676.0RegionNote=Globular terminal domain
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+1432302_330764.01676.0RegionNote=WD40-like repeat 7
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+1432449_465764.01676.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+1432480_523764.01676.0RegionNote=Flexible linker
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+1432524_634764.01676.0RegionNote=Distal segment
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+143268_107764.01676.0RegionNote=WD40-like repeat 2
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+1431108_149764.01640.0RegionNote=WD40-like repeat 3
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+1431150_195764.01640.0RegionNote=WD40-like repeat 4
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+1431196_257764.01640.0RegionNote=WD40-like repeat 5
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+143124_67764.01640.0RegionNote=WD40-like repeat 1
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+1431258_301764.01640.0RegionNote=WD40-like repeat 6
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+14312_479764.01640.0RegionNote=Globular terminal domain
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+1431302_330764.01640.0RegionNote=WD40-like repeat 7
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+1431449_465764.01640.0RegionBinding site for the uncoating ATPase%2C involved in lattice disassembly
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+1431480_523764.01640.0RegionNote=Flexible linker
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+1431524_634764.01640.0RegionNote=Distal segment
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+143168_107764.01640.0RegionNote=WD40-like repeat 2
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+1432537_683764.01676.0RepeatCHCR 1
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+1431537_683764.01640.0RepeatCHCR 1
TgeneRPS6KB1chr17:57746301chr17:57987923ENST00000225577015353_42347.0526.0DomainAGC-kinase C-terminal
TgeneRPS6KB1chr17:57746301chr17:57987923ENST0000022557701591_35247.0526.0DomainProtein kinase
TgeneRPS6KB1chr17:57746301chr17:57987923ENST0000022557701597_10547.0526.0Nucleotide bindingATP
TgeneRPS6KB1chr17:57746301chr17:57987923ENST00000225577015424_52547.0526.0RegionNote=Autoinhibitory domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+14321213_1522764.01676.0RegionInvolved in binding clathrin light chain
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+14321550_1675764.01676.0RegionTrimerization
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+1432524_1675764.01676.0RegionNote=Heavy chain arm
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+1432639_1675764.01676.0RegionNote=Proximal segment
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+14311213_1522764.01640.0RegionInvolved in binding clathrin light chain
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+14311550_1675764.01640.0RegionTrimerization
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+1431524_1675764.01640.0RegionNote=Heavy chain arm
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+1431639_1675764.01640.0RegionNote=Proximal segment
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+14321128_1269764.01676.0RepeatCHCR 5
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+14321274_1420764.01676.0RepeatCHCR 6
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+14321423_1566764.01676.0RepeatCHCR 7
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+1432686_828764.01676.0RepeatCHCR 2
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+1432833_972764.01676.0RepeatCHCR 3
HgeneCLTCchr17:57746301chr17:57987923ENST00000269122+1432979_1124764.01676.0RepeatCHCR 4
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+14311128_1269764.01640.0RepeatCHCR 5
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+14311274_1420764.01640.0RepeatCHCR 6
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+14311423_1566764.01640.0RepeatCHCR 7
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+1431686_828764.01640.0RepeatCHCR 2
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+1431833_972764.01640.0RepeatCHCR 3
HgeneCLTCchr17:57746301chr17:57987923ENST00000393043+1431979_1124764.01640.0RepeatCHCR 4
TgeneRPS6KB1chr17:57746301chr17:57987923ENST0000022557701528_3247.0526.0MotifNote=TOS motif


Top

Fusion Gene Sequence for CLTC-RPS6KB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000393043_ENST00000443572_TCGA-AC-A62V-01A_CLTC_chr17_57746301_+_RPS6KB1_chr17_57987923_length(transcript)=4283nt_BP=2566nt
GGCGGAGTTCTGTCGCCGGGATCCTTCCGCTGGGCTCAGCCGTTTCCGGAGTCTGCGCTGCGCCCGGTTCCGCCATTGCGGCTCTCCTGG
CCCCTGGAGCCTCCGCCCCCGACCCGAGCTCTTTCGTCTGCCTGCCAGTTTCCTGCGTCCCCGGAGAGGATCCTGCTGAGCCCAGCCTCC
CCCCTCCCCTTCTCCTCCTCTCCCTTGGAGAGCCCGGGCAGCCACTGCCCCGCAGCCCCAGTGACAGGAGGAGACCATAACCCCCGACAG
CGCCATGGCCCAGATTCTGCCAATTCGTTTTCAGGAGCATCTCCAGCTCCAGAACCTGGGTATCAACCCAGCAAACATTGGCTTCAGTAC
CCTGACTATGGAGTCTGACAAATTCATCTGCATTAGAGAAAAAGTAGGAGAGCAGGCCCAGGTGGTAATCATTGATATGAATGACCCAAG
TAATCCAATTCGAAGACCAATTTCAGCAGACAGCGCCATCATGAATCCAGCTAGCAAAGTAATTGCACTGAAAGCTGGGAAAACTCTTCA
GATTTTTAACATTGAAATGAAAAGTAAAATGAAGGCTCATACCATGACTGATGATGTCACCTTTTGGAAATGGATCTCTTTGAATACGGT
TGCTCTTGTTACGGATAATGCAGTTTATCACTGGAGTATGGAAGGAGAGTCTCAGCCAGTGAAAATGTTTGATCGCCATTCTAGCCTTGC
AGGGTGCCAGATTATCAATTACCGTACAGATGCAAAACAAAAGTGGTTACTTCTGACTGGTATATCTGCACAGCAAAATCGTGTGGTGGG
AGCTATGCAGCTATATTCTGTAGATAGGAAAGTGTCTCAGCCCATTGAAGGACATGCAGCTAGCTTTGCACAGTTTAAGATGGAAGGAAA
TGCAGAAGAATCAACGTTATTTTGTTTTGCAGTTCGGGGCCAAGCTGGAGGGAAGTTACATATTATTGAAGTTGGCACACCACCTACAGG
GAACCAGCCCTTTCCAAAGAAGGCAGTGGATGTCTTCTTTCCTCCAGAAGCACAAAATGATTTTCCTGTTGCAATGCAGATCAGTGAAAA
GCATGATGTGGTGTTCTTGATAACCAAGTATGGTTATATCCACCTCTATGATCTTGAGACTGGTACCTGCATCTACATGAATAGAATCAG
TGGAGAAACAATTTTTGTTACTGCACCTCATGAAGCCACAGCTGGAATAATTGGAGTAAACAGAAAGGGACAAGTTCTGTCAGTGTGTGT
GGAAGAAGAAAACATAATTCCTTACATCACCAATGTTCTACAAAATCCTGATTTGGCTCTGAGAATGGCTGTACGTAATAACTTAGCCGG
TGCTGAAGAACTCTTTGCCCGGAAATTTAATGCTCTTTTTGCCCAGGGAAATTACTCGGAGGCAGCAAAGGTGGCTGCTAATGCACCAAA
GGGAATTCTTCGTACTCCAGACACTATCCGTCGGTTCCAGAGTGTCCCAGCCCAGCCAGGTCAAACTTCTCCTCTACTTCAGTACTTTGG
TATCCTTTTGGACCAGGGACAGCTCAACAAATACGAATCCTTAGAGCTTTGTAGGCCTGTACTTCAGCAAGGGCGAAAACAGCTTTTGGA
GAAATGGTTAAAAGAAGATAAGCTGGAATGTTCTGAAGAACTGGGTGATCTTGTGAAATCTGTGGACCCTACATTGGCACTTAGTGTGTA
CCTAAGGGCTAACGTCCCAAATAAAGTCATTCAGTGCTTTGCAGAAACAGGTCAAGTCCAAAAGATTGTTTTATATGCTAAAAAAGTTGG
ATACACTCCAGATTGGATATTTCTGCTGAGAAATGTAATGCGAATCAGTCCAGATCAGGGACAGCAGTTTGCCCAAATGTTAGTTCAAGA
TGAAGAGCCTCTTGCTGACATCACACAGATTGTAGATGTCTTTATGGAATACAATCTAATTCAGCAGTGTACTGCATTCTTGCTTGATGC
TCTGAAGAATAATCGCCCATCTGAAGGTCCTTTACAGACGCGGTTACTTGAGATGAACCTTATGCATGCGCCTCAAGTTGCAGATGCTAT
TCTAGGCAATCAGATGTTCACACATTATGACCGGGCTCATATTGCTCAACTGTGTGAAAAGGCTGGCCTACTGCAGCGTGCATTAGAACA
TTTCACTGATTTATATGATATAAAACGTGCAGTGGTTCACACCCATCTTCTTAACCCTGAGTGGTTAGTCAACTACTTTGGTTCCTTATC
AGTAGAAGACTCCCTAGAATGTCTCAGAGCCATGCTGTCTGCCAACATCCGTCAGAATCTGCAGATTTGTGTTCAGGTGGCTTCTAAATA
TCATGAACAACTGTCAACTCAGTCTCTGATTGAACTTTTTGAATCTTTCAAGAGTTTTGAAGGTCTCTTTTATTTTCTGGGATCCATTGT
TAACTTTAGCCAGGACCCAGATGTGCACTTTAAATATATTCAGGCAGCTTGCAAGACTGGGCAAATCAAAGAAGTAGAAAGAATCTGTAG
AGAAAGCAACTGCTACGATCCTGAGCGAGTCAAGAATTTTCTTAAGGGTCAGTTAAATGAAAGCATGGACCATGGGGGAGTTGGACCATA
TGAACTTGGCATGGAACATTGTGAGAAATTTGAAATCTCAGAAACTAGTGTGAACAGAGGGCCAGAAAAAATCAGACCAGAATGTTTTGA
GCTACTTCGGGTACTTGGTAAAGGGGGCTATGGAAAGGCAATGATAGTAAGAAATGCTAAAGATACAGCTCATACAAAAGCAGAACGGAA
TATTCTGGAGGAAGTAAAGCATCCCTTCATCGTGGATTTAATTTATGCCTTTCAGACTGGTGGAAAACTCTACCTCATCCTTGAGTATCT
CAGTGGAGGAGAACTATTTATGCAGTTAGAAAGAGAGGGAATATTTATGGAAGACACTGCCTGCTTTTACTTGGCAGAAATCTCCATGGC
TTTGGGGCATTTACATCAAAAGGGGATCATCTACAGAGACCTGAAGCCGGAGAATATCATGCTTAATCACCAAGGTCATGTGAAACTAAC
AGACTTTGGACTATGCAAAGAATCTATTCATGATGGAACAGTCACACACACATTTTGTGGAACAATAGAATACATGGCCCCTGAAATCTT
GATGAGAAGTGGCCACAATCGTGCTGTGGATTGGTGGAGTTTGGGAGCATTAATGTATGACATGCTGACTGGAGCACCCCCATTCACTGG
GGAGAATAGAAAGAAAACAATTGACAAAATCCTCAAATGTAAACTCAATTTGCCTCCCTACCTCACACAAGAAGCCAGAGATCTGCTTAA
AAAGCTGCTGAAAAGAAATGCTGCTTCTCGTCTGGGAGCTGGTCCTGGGGACGCTGGAGAAGTTCAAGCTCATCCATTCTTTAGACACAT
TAACTGGGAAGAACTTCTGGCTCGAAAGGTGGAGCCCCCCTTTAAACCTCTGTTGCAATCTGAAGAGGATGTAAGTCAGTTTGATTCCAA
GTTTACACGTCAGACACCTGTCGACAGCCCAGATGACTCAACTCTCAGTGAAAGTGCCAATCAGGTCTTTCTGGGTTTTACATATGTGGC
TCCATCTGTACTTGAAAGTGTGAAAGAAAAGTTTTCCTTTGAACCAAAAATCCGATCACCTCGAAGATTTATTGGCAGCCCACGAACACC
TGTCAGCCCAGTCAAATTTTCTCCTGGGGATTTCTGGGGAAGAGGTGCTTCGGCCAGCACAGCAAATCCTCAGACACCTGTGGAATACCC
AATGGAAACAAGTGGCATAGAGCAGATGGATGTGACAATGAGTGGGGAAGCATCGGCACCACTTCCAATACGACAGCCGAACTCTGGGCC
ATACAAAAAACAAGCTTTTCCCATGATCTCCAAACGGCCAGAGCACCTGCGTATGAATCTATGACAGAGCAATGCTTTTAATGAATTTAA
GGCAAAAAAGGTGGAGAGGGAGATGTGTGAGCATCCTGCAAGGTGAAACGACTCAAAATGACAGTTTCAGAGAGTCAATGTCATTACATA
GAACACTTCAGACACAGGAAAAATAAACGTGGATTTTAAAAAATCAATCAATGGTGCAAAAAAAAACTTAAAGCAAAATAGTATTGCTGA
ACTCTTAGGCACATCAATTAATTGATTCCTCGCGACATCTTCTCAACCTTATCAAGGATTTTCATGTTGATGACTCGAAACTGACAGTAT

>In-frame_ENST00000393043_ENST00000443572_TCGA-AC-A62V-01A_CLTC_chr17_57746301_+_RPS6KB1_chr17_57987923_length(amino acids)=1219AA_start in transcript=274_stop in transcript=3933
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFEL
LRVLGKGGYGKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMAL
GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGE
NRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKF
TRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPM

--------------------------------------------------------------
>In-frame_ENST00000393043_ENST00000406116_TCGA-AC-A62V-01A_CLTC_chr17_57746301_+_RPS6KB1_chr17_57987923_length(transcript)=4367nt_BP=2566nt
GGCGGAGTTCTGTCGCCGGGATCCTTCCGCTGGGCTCAGCCGTTTCCGGAGTCTGCGCTGCGCCCGGTTCCGCCATTGCGGCTCTCCTGG
CCCCTGGAGCCTCCGCCCCCGACCCGAGCTCTTTCGTCTGCCTGCCAGTTTCCTGCGTCCCCGGAGAGGATCCTGCTGAGCCCAGCCTCC
CCCCTCCCCTTCTCCTCCTCTCCCTTGGAGAGCCCGGGCAGCCACTGCCCCGCAGCCCCAGTGACAGGAGGAGACCATAACCCCCGACAG
CGCCATGGCCCAGATTCTGCCAATTCGTTTTCAGGAGCATCTCCAGCTCCAGAACCTGGGTATCAACCCAGCAAACATTGGCTTCAGTAC
CCTGACTATGGAGTCTGACAAATTCATCTGCATTAGAGAAAAAGTAGGAGAGCAGGCCCAGGTGGTAATCATTGATATGAATGACCCAAG
TAATCCAATTCGAAGACCAATTTCAGCAGACAGCGCCATCATGAATCCAGCTAGCAAAGTAATTGCACTGAAAGCTGGGAAAACTCTTCA
GATTTTTAACATTGAAATGAAAAGTAAAATGAAGGCTCATACCATGACTGATGATGTCACCTTTTGGAAATGGATCTCTTTGAATACGGT
TGCTCTTGTTACGGATAATGCAGTTTATCACTGGAGTATGGAAGGAGAGTCTCAGCCAGTGAAAATGTTTGATCGCCATTCTAGCCTTGC
AGGGTGCCAGATTATCAATTACCGTACAGATGCAAAACAAAAGTGGTTACTTCTGACTGGTATATCTGCACAGCAAAATCGTGTGGTGGG
AGCTATGCAGCTATATTCTGTAGATAGGAAAGTGTCTCAGCCCATTGAAGGACATGCAGCTAGCTTTGCACAGTTTAAGATGGAAGGAAA
TGCAGAAGAATCAACGTTATTTTGTTTTGCAGTTCGGGGCCAAGCTGGAGGGAAGTTACATATTATTGAAGTTGGCACACCACCTACAGG
GAACCAGCCCTTTCCAAAGAAGGCAGTGGATGTCTTCTTTCCTCCAGAAGCACAAAATGATTTTCCTGTTGCAATGCAGATCAGTGAAAA
GCATGATGTGGTGTTCTTGATAACCAAGTATGGTTATATCCACCTCTATGATCTTGAGACTGGTACCTGCATCTACATGAATAGAATCAG
TGGAGAAACAATTTTTGTTACTGCACCTCATGAAGCCACAGCTGGAATAATTGGAGTAAACAGAAAGGGACAAGTTCTGTCAGTGTGTGT
GGAAGAAGAAAACATAATTCCTTACATCACCAATGTTCTACAAAATCCTGATTTGGCTCTGAGAATGGCTGTACGTAATAACTTAGCCGG
TGCTGAAGAACTCTTTGCCCGGAAATTTAATGCTCTTTTTGCCCAGGGAAATTACTCGGAGGCAGCAAAGGTGGCTGCTAATGCACCAAA
GGGAATTCTTCGTACTCCAGACACTATCCGTCGGTTCCAGAGTGTCCCAGCCCAGCCAGGTCAAACTTCTCCTCTACTTCAGTACTTTGG
TATCCTTTTGGACCAGGGACAGCTCAACAAATACGAATCCTTAGAGCTTTGTAGGCCTGTACTTCAGCAAGGGCGAAAACAGCTTTTGGA
GAAATGGTTAAAAGAAGATAAGCTGGAATGTTCTGAAGAACTGGGTGATCTTGTGAAATCTGTGGACCCTACATTGGCACTTAGTGTGTA
CCTAAGGGCTAACGTCCCAAATAAAGTCATTCAGTGCTTTGCAGAAACAGGTCAAGTCCAAAAGATTGTTTTATATGCTAAAAAAGTTGG
ATACACTCCAGATTGGATATTTCTGCTGAGAAATGTAATGCGAATCAGTCCAGATCAGGGACAGCAGTTTGCCCAAATGTTAGTTCAAGA
TGAAGAGCCTCTTGCTGACATCACACAGATTGTAGATGTCTTTATGGAATACAATCTAATTCAGCAGTGTACTGCATTCTTGCTTGATGC
TCTGAAGAATAATCGCCCATCTGAAGGTCCTTTACAGACGCGGTTACTTGAGATGAACCTTATGCATGCGCCTCAAGTTGCAGATGCTAT
TCTAGGCAATCAGATGTTCACACATTATGACCGGGCTCATATTGCTCAACTGTGTGAAAAGGCTGGCCTACTGCAGCGTGCATTAGAACA
TTTCACTGATTTATATGATATAAAACGTGCAGTGGTTCACACCCATCTTCTTAACCCTGAGTGGTTAGTCAACTACTTTGGTTCCTTATC
AGTAGAAGACTCCCTAGAATGTCTCAGAGCCATGCTGTCTGCCAACATCCGTCAGAATCTGCAGATTTGTGTTCAGGTGGCTTCTAAATA
TCATGAACAACTGTCAACTCAGTCTCTGATTGAACTTTTTGAATCTTTCAAGAGTTTTGAAGGTCTCTTTTATTTTCTGGGATCCATTGT
TAACTTTAGCCAGGACCCAGATGTGCACTTTAAATATATTCAGGCAGCTTGCAAGACTGGGCAAATCAAAGAAGTAGAAAGAATCTGTAG
AGAAAGCAACTGCTACGATCCTGAGCGAGTCAAGAATTTTCTTAAGGGTCAGTTAAATGAAAGCATGGACCATGGGGGAGTTGGACCATA
TGAACTTGGCATGGAACATTGTGAGAAATTTGAAATCTCAGAAACTAGTGTGAACAGAGGGCCAGAAAAAATCAGACCAGAATGTTTTGA
GCTACTTCGGGTACTTGGTAAAGGGGGCTATGGAAAGGTTTTTCAAGTACGAAAAGTAACAGGAGCAAATACTGGGAAAATATTTGCCAT
GAAGGTGCTTAAAAAGGCAATGATAGTAAGAAATGCTAAAGATACAGCTCATACAAAAGCAGAACGGAATATTCTGGAGGAAGTAAAGCA
TCCCTTCATCGTGGATTTAATTTATGCCTTTCAGACTGGTGGAAAACTCTACCTCATCCTTGAGTATCTCAGTGGAGGAGAACTATTTAT
GCAGTTAGAAAGAGAGGGAATATTTATGGAAGACACTGCCTGCTTTTACTTGGCAGAAATCTCCATGGCTTTGGGGCATTTACATCAAAA
GGGGATCATCTACAGAGACCTGAAGCCGGAGAATATCATGCTTAATCACCAAGGTCATGTGAAACTAACAGACTTTGGACTATGCAAAGA
ATCTATTCATGATGGAACAGTCACACACACATTTTGTGGAACAATAGAATACATGGCCCCTGAAATCTTGATGAGAAGTGGCCACAATCG
TGCTGTGGATTGGTGGAGTTTGGGAGCATTAATGTATGACATGCTGACTGGAGCACCCCCATTCACTGGGGAGAATAGAAAGAAAACAAT
TGACAAAATCCTCAAATGTAAACTCAATTTGCCTCCCTACCTCACACAAGAAGCCAGAGATCTGCTTAAAAAGCTGCTGAAAAGAAATGC
TGCTTCTCGTCTGGGAGCTGGTCCTGGGGACGCTGGAGAAGTTCAAGCTCATCCATTCTTTAGACACATTAACTGGGAAGAACTTCTGGC
TCGAAAGGTGGAGCCCCCCTTTAAACCTCTGTTGCAATCTGAAGAGGATGTAAGTCAGTTTGATTCCAAGTTTACACGTCAGACACCTGT
CGACAGCCCAGATGACTCAACTCTCAGTGAAAGTGCCAATCAGGTCTTTCTGGGTTTTACATATGTGGCTCCATCTGTACTTGAAAGTGT
GAAAGAAAAGTTTTCCTTTGAACCAAAAATCCGATCACCTCGAAGATTTATTGGCAGCCCACGAACACCTGTCAGTACTGCTATGTGCTA
AGCTTAACTGGAAGCCTTGGAATGGGCATAAGTTGTATGTCCTACATTTCATCATTGTCCCGGGCCTGCATTGCACTGGAAAAAAAAATC
GCCACCTGTTCTTACACCAGTATTTGGTTCAAGACACCAAATGTCTTCAGCCCATGGCTGAAGAACAACAGAAGAGAGTCAGGATAAAAA
ATACATACTGTGGTCGGCAAGGTGAGGGAGATAGGGATATCCAGGGGAAGAGGGTGTTGCTGTGGCCCACTCTCTGTCTAATCTCTTTAC
AGCAAATTGGTAAGATTTTCAGTTTTACTTCTTTCTACTGTTTCTGCTGTCTACCTTCCTTATATTTTTTTCCTCAACAGTTTTAAAAAG
AAAAAAAGGTCTATTTTTTTTTCTCCTATACTTGGGCTACATTTTTTGATTGTAAAAATATTTGATGGCCTTTTGATGAATGTCTTCCAC
AGTAAAGAAAACTTAGTGGCTTAATTTAGGAAACATGTTAACAGGACACTATGTTTTTGAAATTGTAACAAAATCTACATAAATGATTTA

>In-frame_ENST00000393043_ENST00000406116_TCGA-AC-A62V-01A_CLTC_chr17_57746301_+_RPS6KB1_chr17_57987923_length(amino acids)=1168AA_start in transcript=274_stop in transcript=3780
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFEL
LRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQ
LEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRA
VDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLAR

--------------------------------------------------------------
>In-frame_ENST00000393043_ENST00000225577_TCGA-AC-A62V-01A_CLTC_chr17_57746301_+_RPS6KB1_chr17_57987923_length(transcript)=7779nt_BP=2566nt
GGCGGAGTTCTGTCGCCGGGATCCTTCCGCTGGGCTCAGCCGTTTCCGGAGTCTGCGCTGCGCCCGGTTCCGCCATTGCGGCTCTCCTGG
CCCCTGGAGCCTCCGCCCCCGACCCGAGCTCTTTCGTCTGCCTGCCAGTTTCCTGCGTCCCCGGAGAGGATCCTGCTGAGCCCAGCCTCC
CCCCTCCCCTTCTCCTCCTCTCCCTTGGAGAGCCCGGGCAGCCACTGCCCCGCAGCCCCAGTGACAGGAGGAGACCATAACCCCCGACAG
CGCCATGGCCCAGATTCTGCCAATTCGTTTTCAGGAGCATCTCCAGCTCCAGAACCTGGGTATCAACCCAGCAAACATTGGCTTCAGTAC
CCTGACTATGGAGTCTGACAAATTCATCTGCATTAGAGAAAAAGTAGGAGAGCAGGCCCAGGTGGTAATCATTGATATGAATGACCCAAG
TAATCCAATTCGAAGACCAATTTCAGCAGACAGCGCCATCATGAATCCAGCTAGCAAAGTAATTGCACTGAAAGCTGGGAAAACTCTTCA
GATTTTTAACATTGAAATGAAAAGTAAAATGAAGGCTCATACCATGACTGATGATGTCACCTTTTGGAAATGGATCTCTTTGAATACGGT
TGCTCTTGTTACGGATAATGCAGTTTATCACTGGAGTATGGAAGGAGAGTCTCAGCCAGTGAAAATGTTTGATCGCCATTCTAGCCTTGC
AGGGTGCCAGATTATCAATTACCGTACAGATGCAAAACAAAAGTGGTTACTTCTGACTGGTATATCTGCACAGCAAAATCGTGTGGTGGG
AGCTATGCAGCTATATTCTGTAGATAGGAAAGTGTCTCAGCCCATTGAAGGACATGCAGCTAGCTTTGCACAGTTTAAGATGGAAGGAAA
TGCAGAAGAATCAACGTTATTTTGTTTTGCAGTTCGGGGCCAAGCTGGAGGGAAGTTACATATTATTGAAGTTGGCACACCACCTACAGG
GAACCAGCCCTTTCCAAAGAAGGCAGTGGATGTCTTCTTTCCTCCAGAAGCACAAAATGATTTTCCTGTTGCAATGCAGATCAGTGAAAA
GCATGATGTGGTGTTCTTGATAACCAAGTATGGTTATATCCACCTCTATGATCTTGAGACTGGTACCTGCATCTACATGAATAGAATCAG
TGGAGAAACAATTTTTGTTACTGCACCTCATGAAGCCACAGCTGGAATAATTGGAGTAAACAGAAAGGGACAAGTTCTGTCAGTGTGTGT
GGAAGAAGAAAACATAATTCCTTACATCACCAATGTTCTACAAAATCCTGATTTGGCTCTGAGAATGGCTGTACGTAATAACTTAGCCGG
TGCTGAAGAACTCTTTGCCCGGAAATTTAATGCTCTTTTTGCCCAGGGAAATTACTCGGAGGCAGCAAAGGTGGCTGCTAATGCACCAAA
GGGAATTCTTCGTACTCCAGACACTATCCGTCGGTTCCAGAGTGTCCCAGCCCAGCCAGGTCAAACTTCTCCTCTACTTCAGTACTTTGG
TATCCTTTTGGACCAGGGACAGCTCAACAAATACGAATCCTTAGAGCTTTGTAGGCCTGTACTTCAGCAAGGGCGAAAACAGCTTTTGGA
GAAATGGTTAAAAGAAGATAAGCTGGAATGTTCTGAAGAACTGGGTGATCTTGTGAAATCTGTGGACCCTACATTGGCACTTAGTGTGTA
CCTAAGGGCTAACGTCCCAAATAAAGTCATTCAGTGCTTTGCAGAAACAGGTCAAGTCCAAAAGATTGTTTTATATGCTAAAAAAGTTGG
ATACACTCCAGATTGGATATTTCTGCTGAGAAATGTAATGCGAATCAGTCCAGATCAGGGACAGCAGTTTGCCCAAATGTTAGTTCAAGA
TGAAGAGCCTCTTGCTGACATCACACAGATTGTAGATGTCTTTATGGAATACAATCTAATTCAGCAGTGTACTGCATTCTTGCTTGATGC
TCTGAAGAATAATCGCCCATCTGAAGGTCCTTTACAGACGCGGTTACTTGAGATGAACCTTATGCATGCGCCTCAAGTTGCAGATGCTAT
TCTAGGCAATCAGATGTTCACACATTATGACCGGGCTCATATTGCTCAACTGTGTGAAAAGGCTGGCCTACTGCAGCGTGCATTAGAACA
TTTCACTGATTTATATGATATAAAACGTGCAGTGGTTCACACCCATCTTCTTAACCCTGAGTGGTTAGTCAACTACTTTGGTTCCTTATC
AGTAGAAGACTCCCTAGAATGTCTCAGAGCCATGCTGTCTGCCAACATCCGTCAGAATCTGCAGATTTGTGTTCAGGTGGCTTCTAAATA
TCATGAACAACTGTCAACTCAGTCTCTGATTGAACTTTTTGAATCTTTCAAGAGTTTTGAAGGTCTCTTTTATTTTCTGGGATCCATTGT
TAACTTTAGCCAGGACCCAGATGTGCACTTTAAATATATTCAGGCAGCTTGCAAGACTGGGCAAATCAAAGAAGTAGAAAGAATCTGTAG
AGAAAGCAACTGCTACGATCCTGAGCGAGTCAAGAATTTTCTTAAGGGTCAGTTAAATGAAAGCATGGACCATGGGGGAGTTGGACCATA
TGAACTTGGCATGGAACATTGTGAGAAATTTGAAATCTCAGAAACTAGTGTGAACAGAGGGCCAGAAAAAATCAGACCAGAATGTTTTGA
GCTACTTCGGGTACTTGGTAAAGGGGGCTATGGAAAGGTTTTTCAAGTACGAAAAGTAACAGGAGCAAATACTGGGAAAATATTTGCCAT
GAAGGTGCTTAAAAAGGCAATGATAGTAAGAAATGCTAAAGATACAGCTCATACAAAAGCAGAACGGAATATTCTGGAGGAAGTAAAGCA
TCCCTTCATCGTGGATTTAATTTATGCCTTTCAGACTGGTGGAAAACTCTACCTCATCCTTGAGTATCTCAGTGGAGGAGAACTATTTAT
GCAGTTAGAAAGAGAGGGAATATTTATGGAAGACACTGCCTGCTTTTACTTGGCAGAAATCTCCATGGCTTTGGGGCATTTACATCAAAA
GGGGATCATCTACAGAGACCTGAAGCCGGAGAATATCATGCTTAATCACCAAGGTCATGTGAAACTAACAGACTTTGGACTATGCAAAGA
ATCTATTCATGATGGAACAGTCACACACACATTTTGTGGAACAATAGAATACATGGCCCCTGAAATCTTGATGAGAAGTGGCCACAATCG
TGCTGTGGATTGGTGGAGTTTGGGAGCATTAATGTATGACATGCTGACTGGAGCACCCCCATTCACTGGGGAGAATAGAAAGAAAACAAT
TGACAAAATCCTCAAATGTAAACTCAATTTGCCTCCCTACCTCACACAAGAAGCCAGAGATCTGCTTAAAAAGCTGCTGAAAAGAAATGC
TGCTTCTCGTCTGGGAGCTGGTCCTGGGGACGCTGGAGAAGTTCAAGCTCATCCATTCTTTAGACACATTAACTGGGAAGAACTTCTGGC
TCGAAAGGTGGAGCCCCCCTTTAAACCTCTGTTGCAATCTGAAGAGGATGTAAGTCAGTTTGATTCCAAGTTTACACGTCAGACACCTGT
CGACAGCCCAGATGACTCAACTCTCAGTGAAAGTGCCAATCAGGTCTTTCTGGGTTTTACATATGTGGCTCCATCTGTACTTGAAAGTGT
GAAAGAAAAGTTTTCCTTTGAACCAAAAATCCGATCACCTCGAAGATTTATTGGCAGCCCACGAACACCTGTCAGCCCAGTCAAATTTTC
TCCTGGGGATTTCTGGGGAAGAGGTGCTTCGGCCAGCACAGCAAATCCTCAGACACCTGTGGAATACCCAATGGAAACAAGTGGCATAGA
GCAGATGGATGTGACAATGAGTGGGGAAGCATCGGCACCACTTCCAATACGACAGCCGAACTCTGGGCCATACAAAAAACAAGCTTTTCC
CATGATCTCCAAACGGCCAGAGCACCTGCGTATGAATCTATGACAGAGCAATGCTTTTAATGAATTTAAGGCAAAAAAGGTGGAGAGGGA
GATGTGTGAGCATCCTGCAAGGTGAAACGACTCAAAATGACAGTTTCAGAGAGTCAATGTCATTACATAGAACACTTCAGACACAGGAAA
AATAAACGTGGATTTTAAAAAATCAATCAATGGTGCAAAAAAAAACTTAAAGCAAAATAGTATTGCTGAACTCTTAGGCACATCAATTAA
TTGATTCCTCGCGACATCTTCTCAACCTTATCAAGGATTTTCATGTTGATGACTCGAAACTGACAGTATTAAGGGTAGGATGTTGCTTCT
GAATCACTGTTGAGTTCTGATTGTGTTGAAGAAGGGTTATCCTTTCATTAGGCAAAGTACAAAATTGCCTATAATACTTGCAACTAAGGA
CAAATTAGCATGCAAGCTTGGTCAAACTTTTTCCAGCAAAATGGAAGCAAAGACAAAAGAAACTTACCAATTGATGTTTTACGTGCAAAC
AACCTGAATCTTTTTTTTATATAAATATATATTTTTCAAATAGATTTTTGATTCAGCTCATTATGAAAAACATCCCAAACTTTAAAATGC
GAAATTATTGGTTGGTGTGAAGAAAGCCAGACAACTTCTGTTTCTTCTCTTGGTGAAATAATAAAATGCAAATGAATCATTGTTAACCAC
AGCTGTGGCTCGTTTGAGGGATTGGGGTGGACCTGGGGTTTATTTTCAGTAACCCAGCTGCAATACCTGTCTGTAATATGAGAAAAAAAA
AATGAATCTATTTAATCATTTCTACTTGCAGTACTGCTATGTGCTAAGCTTAACTGGAAGCCTTGGAATGGGCATAAGTTGTATGTCCTA
CATTTCATCATTGTCCCGGGCCTGCATTGCACTGGAAAAAAAAATCGCCACCTGTTCTTACACCAGTATTTGGTTCAAGACACCAAATGT
CTTCAGCCCATGGCTGAAGAACAACAGAAGAGAGTCAGGATAAAAAATACATACTGTGGTCGGCAAGGTGAGGGAGATAGGGATATCCAG
GGGAAGAGGGTGTTGCTGTGGCCCACTCTCTGTCTAATCTCTTTACAGCAAATTGGTAAGATTTTCAGTTTTACTTCTTTCTACTGTTTC
TGCTGTCTACCTTCCTTATATTTTTTTCCTCAACAGTTTTAAAAAGAAAAAAAGGTCTATTTTTTTTTCTCCTATACTTGGGCTACATTT
TTTGATTGTAAAAATATTTGATGGCCTTTTGATGAATGTCTTCCACAGTAAAGAAAACTTAGTGGCTTAATTTAGGAAACATGTTAACAG
GACACTATGTTTTTGAAATTGTAACAAAATCTACATAAATGATTTACAGGTTAAAAGAATAAAAATAAAGGTAACTTTACCTTTCTTAAA
TATTTCCTGCCTTAAAGAGAGCATTTCCATGACTTTAGCTGGTGAAAGGGTTTAATATCTGCAGAGCTTTATAAAAATATATTTCAGTGC
ATACTGGTATAATAGATGATCATGCAGTTGCAGTTGAGTTGTATCACCTTTTTTGTTTGTCTTTTATAATGTCTTCAGTCTGAGTGTGCA
AAGTCAATTTGTAATATTTTGCAACCCTAGGATTTTTTTAAATAGATGCTGCTTGCTATGTTTTCAAACCTTTTTGAGCCATAGGATCCA
AGCCATAAAATTCTTTATGCATGTTGAATTCAGTCAGAAAAGAGCAAGGCTTTGCTTTTTGAAATTGCAACTCAAATGAGATGGGATGAA
ATCCTATGACAGTAAGCAAAAACAGAACCATGAAAAATGATTGGACATACACCTTTTCAATTGTGGCAATAATTGAAAGAATCGATAAAA
GTTCATCTTTGGACAGAAAGCCTTTAAAAAAAAAATCACTCCCTCTTCCCCCTCCTCCCTTATTGCAGCAGCCTACTGAGAACTTTGACT
GTTGCTGGTAAATTAGAAGCTACAATAATAATTAAGGGCAGAAATTATACTTAAAAAGTGCAGATCCTTGTTCTTTGACAATTTGTGATG
TCTGAAAAAACAGAACCCGAAAAGCTATGGTGATATGTACAGGCATTATTTCAGACTGTAAATGGCTTGTGATACTCTTGATACTTGTTT
TCAAATATGTTTACTAACTGTAGTGTTGACTGCCTGACCAAATTCCAGTGAAACTTATACACCAAAATATTCTTCCTAGGTCCTATTTGC
TAGTAACATGAGCACTGTGATTGGCTGGCTATAACCACCCCAGTTAAACCATTTTCATAATTAGTAGTGCCAGCAATAGTGGCAAACACT
GCAACTTTTCTGCATAAAAAGCATTAATTGCACAGCTACCATCCACACAAATACATAGTTTTTCTGACTTCACATTTATTAAGTGAAATT
TATTTCCCATGCTGTGGAAAGTTTATTGAGAACTTGTTTCATAAATGGATATCCCTACTATGACTGTGAAAACATGTCAAGTGTCACATT
AGTGTCACAGACAGAAAGCACACACCTATGCAATATGGCTTATCTATATTTATTTGTAAAAATCCAAGCATAGTTTAAAATATGATGTCG
ATATTACTAGTCTTGAGTTTCTAAGAGGGTTCTTTATGTTATACCAGGTAAGTGTATAAAAGAGATTAAGTGCTTTTTTTTCATCACTTG
ATTATTTTCTTTAAAATCAGCTATTACAGGATATTTTTTTATTTTATACATGCTGTTTTTTAATTAAAATATAATCACTGAAGTTTACTA
ATTTGATTTTATAAGGTTTGTAGCATTACAGAATAACTAAACTGGGATTTATAAACCAGCTGTGATTAACAATGTAAAGTATTAATTATT
GAACTTTGAACCAGATTTTTAGGAAAATTATGTTCTTTTTCCCCCTTTATGGTCTTAACTAATTTGAATCCTTCAAGAAGGATTTTTCCA
TACTATTTTTTAAGATAGAAGATAATTTGTGGGCAGGGGTGGAGGATGCATGTATGATACTCCATAAATTCAACATTCTTTACTATAGGT
AATGAATGATTATAAACAAGATGCATCTTAGATAGTATTAATATACTGAGCCTTGGATTATATATTTAATATAGGACCTATTTTGAATAT
TCAGTTAATCATATGGTTCCTAGCTTACAAGGGCTAGATCTAAGATTATTCCCATGAGAAATGTTGAATTTATGAAGAATAGATTTTAAG
GCTTTGAAAATGGTTAATTTCTCAAAAACATCAATGTCCAAACATCTACCTTTTTTCATAGGAGTAGACACTAGCAAGCTGGACAAACTA
TCACAAAAGTATTTGTCACACATAACCTGTGGTCTGTTGCTGATTAATACAGTACTTTTTCTTGTGTGATTCTTAACATTATAGCACAAG
TATTATCTCAGTGGATTATCCGGAATAACATCTGAAAGATGGGTTCATCTATGTTTGTGTTTGCTCTTTAAACTATTGTTTCTCCTATCC
CAAGTTCGCTTTGCATCTATCAGTAAATAAAATTCTTCAGCTGCCTTATTAGGAGTGCTATGAGGGTAACACCTGTTCTGCTTTTCATCT
TGTATTTAGTTGACTGTATTATTTGATTTCGGATTGAATGAATGTAAATAGAAATTAAATGCAAATTTGAATGAACATAAATAGAAGTGA
TTTATTTTTTTATTATCTTAAAGATAGGAAGGAATTAGTATACGTATCAGGTGTATAAATGGTTTAAATTTATTTTAACATGTCAGATGT

>In-frame_ENST00000393043_ENST00000225577_TCGA-AC-A62V-01A_CLTC_chr17_57746301_+_RPS6KB1_chr17_57987923_length(amino acids)=1242AA_start in transcript=274_stop in transcript=4002
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFEL
LRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQ
LEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRA
VDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLAR
KVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSP

--------------------------------------------------------------
>In-frame_ENST00000269122_ENST00000443572_TCGA-AC-A62V-01A_CLTC_chr17_57746301_+_RPS6KB1_chr17_57987923_length(transcript)=4283nt_BP=2566nt
GGCGGAGTTCTGTCGCCGGGATCCTTCCGCTGGGCTCAGCCGTTTCCGGAGTCTGCGCTGCGCCCGGTTCCGCCATTGCGGCTCTCCTGG
CCCCTGGAGCCTCCGCCCCCGACCCGAGCTCTTTCGTCTGCCTGCCAGTTTCCTGCGTCCCCGGAGAGGATCCTGCTGAGCCCAGCCTCC
CCCCTCCCCTTCTCCTCCTCTCCCTTGGAGAGCCCGGGCAGCCACTGCCCCGCAGCCCCAGTGACAGGAGGAGACCATAACCCCCGACAG
CGCCATGGCCCAGATTCTGCCAATTCGTTTTCAGGAGCATCTCCAGCTCCAGAACCTGGGTATCAACCCAGCAAACATTGGCTTCAGTAC
CCTGACTATGGAGTCTGACAAATTCATCTGCATTAGAGAAAAAGTAGGAGAGCAGGCCCAGGTGGTAATCATTGATATGAATGACCCAAG
TAATCCAATTCGAAGACCAATTTCAGCAGACAGCGCCATCATGAATCCAGCTAGCAAAGTAATTGCACTGAAAGCTGGGAAAACTCTTCA
GATTTTTAACATTGAAATGAAAAGTAAAATGAAGGCTCATACCATGACTGATGATGTCACCTTTTGGAAATGGATCTCTTTGAATACGGT
TGCTCTTGTTACGGATAATGCAGTTTATCACTGGAGTATGGAAGGAGAGTCTCAGCCAGTGAAAATGTTTGATCGCCATTCTAGCCTTGC
AGGGTGCCAGATTATCAATTACCGTACAGATGCAAAACAAAAGTGGTTACTTCTGACTGGTATATCTGCACAGCAAAATCGTGTGGTGGG
AGCTATGCAGCTATATTCTGTAGATAGGAAAGTGTCTCAGCCCATTGAAGGACATGCAGCTAGCTTTGCACAGTTTAAGATGGAAGGAAA
TGCAGAAGAATCAACGTTATTTTGTTTTGCAGTTCGGGGCCAAGCTGGAGGGAAGTTACATATTATTGAAGTTGGCACACCACCTACAGG
GAACCAGCCCTTTCCAAAGAAGGCAGTGGATGTCTTCTTTCCTCCAGAAGCACAAAATGATTTTCCTGTTGCAATGCAGATCAGTGAAAA
GCATGATGTGGTGTTCTTGATAACCAAGTATGGTTATATCCACCTCTATGATCTTGAGACTGGTACCTGCATCTACATGAATAGAATCAG
TGGAGAAACAATTTTTGTTACTGCACCTCATGAAGCCACAGCTGGAATAATTGGAGTAAACAGAAAGGGACAAGTTCTGTCAGTGTGTGT
GGAAGAAGAAAACATAATTCCTTACATCACCAATGTTCTACAAAATCCTGATTTGGCTCTGAGAATGGCTGTACGTAATAACTTAGCCGG
TGCTGAAGAACTCTTTGCCCGGAAATTTAATGCTCTTTTTGCCCAGGGAAATTACTCGGAGGCAGCAAAGGTGGCTGCTAATGCACCAAA
GGGAATTCTTCGTACTCCAGACACTATCCGTCGGTTCCAGAGTGTCCCAGCCCAGCCAGGTCAAACTTCTCCTCTACTTCAGTACTTTGG
TATCCTTTTGGACCAGGGACAGCTCAACAAATACGAATCCTTAGAGCTTTGTAGGCCTGTACTTCAGCAAGGGCGAAAACAGCTTTTGGA
GAAATGGTTAAAAGAAGATAAGCTGGAATGTTCTGAAGAACTGGGTGATCTTGTGAAATCTGTGGACCCTACATTGGCACTTAGTGTGTA
CCTAAGGGCTAACGTCCCAAATAAAGTCATTCAGTGCTTTGCAGAAACAGGTCAAGTCCAAAAGATTGTTTTATATGCTAAAAAAGTTGG
ATACACTCCAGATTGGATATTTCTGCTGAGAAATGTAATGCGAATCAGTCCAGATCAGGGACAGCAGTTTGCCCAAATGTTAGTTCAAGA
TGAAGAGCCTCTTGCTGACATCACACAGATTGTAGATGTCTTTATGGAATACAATCTAATTCAGCAGTGTACTGCATTCTTGCTTGATGC
TCTGAAGAATAATCGCCCATCTGAAGGTCCTTTACAGACGCGGTTACTTGAGATGAACCTTATGCATGCGCCTCAAGTTGCAGATGCTAT
TCTAGGCAATCAGATGTTCACACATTATGACCGGGCTCATATTGCTCAACTGTGTGAAAAGGCTGGCCTACTGCAGCGTGCATTAGAACA
TTTCACTGATTTATATGATATAAAACGTGCAGTGGTTCACACCCATCTTCTTAACCCTGAGTGGTTAGTCAACTACTTTGGTTCCTTATC
AGTAGAAGACTCCCTAGAATGTCTCAGAGCCATGCTGTCTGCCAACATCCGTCAGAATCTGCAGATTTGTGTTCAGGTGGCTTCTAAATA
TCATGAACAACTGTCAACTCAGTCTCTGATTGAACTTTTTGAATCTTTCAAGAGTTTTGAAGGTCTCTTTTATTTTCTGGGATCCATTGT
TAACTTTAGCCAGGACCCAGATGTGCACTTTAAATATATTCAGGCAGCTTGCAAGACTGGGCAAATCAAAGAAGTAGAAAGAATCTGTAG
AGAAAGCAACTGCTACGATCCTGAGCGAGTCAAGAATTTTCTTAAGGGTCAGTTAAATGAAAGCATGGACCATGGGGGAGTTGGACCATA
TGAACTTGGCATGGAACATTGTGAGAAATTTGAAATCTCAGAAACTAGTGTGAACAGAGGGCCAGAAAAAATCAGACCAGAATGTTTTGA
GCTACTTCGGGTACTTGGTAAAGGGGGCTATGGAAAGGCAATGATAGTAAGAAATGCTAAAGATACAGCTCATACAAAAGCAGAACGGAA
TATTCTGGAGGAAGTAAAGCATCCCTTCATCGTGGATTTAATTTATGCCTTTCAGACTGGTGGAAAACTCTACCTCATCCTTGAGTATCT
CAGTGGAGGAGAACTATTTATGCAGTTAGAAAGAGAGGGAATATTTATGGAAGACACTGCCTGCTTTTACTTGGCAGAAATCTCCATGGC
TTTGGGGCATTTACATCAAAAGGGGATCATCTACAGAGACCTGAAGCCGGAGAATATCATGCTTAATCACCAAGGTCATGTGAAACTAAC
AGACTTTGGACTATGCAAAGAATCTATTCATGATGGAACAGTCACACACACATTTTGTGGAACAATAGAATACATGGCCCCTGAAATCTT
GATGAGAAGTGGCCACAATCGTGCTGTGGATTGGTGGAGTTTGGGAGCATTAATGTATGACATGCTGACTGGAGCACCCCCATTCACTGG
GGAGAATAGAAAGAAAACAATTGACAAAATCCTCAAATGTAAACTCAATTTGCCTCCCTACCTCACACAAGAAGCCAGAGATCTGCTTAA
AAAGCTGCTGAAAAGAAATGCTGCTTCTCGTCTGGGAGCTGGTCCTGGGGACGCTGGAGAAGTTCAAGCTCATCCATTCTTTAGACACAT
TAACTGGGAAGAACTTCTGGCTCGAAAGGTGGAGCCCCCCTTTAAACCTCTGTTGCAATCTGAAGAGGATGTAAGTCAGTTTGATTCCAA
GTTTACACGTCAGACACCTGTCGACAGCCCAGATGACTCAACTCTCAGTGAAAGTGCCAATCAGGTCTTTCTGGGTTTTACATATGTGGC
TCCATCTGTACTTGAAAGTGTGAAAGAAAAGTTTTCCTTTGAACCAAAAATCCGATCACCTCGAAGATTTATTGGCAGCCCACGAACACC
TGTCAGCCCAGTCAAATTTTCTCCTGGGGATTTCTGGGGAAGAGGTGCTTCGGCCAGCACAGCAAATCCTCAGACACCTGTGGAATACCC
AATGGAAACAAGTGGCATAGAGCAGATGGATGTGACAATGAGTGGGGAAGCATCGGCACCACTTCCAATACGACAGCCGAACTCTGGGCC
ATACAAAAAACAAGCTTTTCCCATGATCTCCAAACGGCCAGAGCACCTGCGTATGAATCTATGACAGAGCAATGCTTTTAATGAATTTAA
GGCAAAAAAGGTGGAGAGGGAGATGTGTGAGCATCCTGCAAGGTGAAACGACTCAAAATGACAGTTTCAGAGAGTCAATGTCATTACATA
GAACACTTCAGACACAGGAAAAATAAACGTGGATTTTAAAAAATCAATCAATGGTGCAAAAAAAAACTTAAAGCAAAATAGTATTGCTGA
ACTCTTAGGCACATCAATTAATTGATTCCTCGCGACATCTTCTCAACCTTATCAAGGATTTTCATGTTGATGACTCGAAACTGACAGTAT

>In-frame_ENST00000269122_ENST00000443572_TCGA-AC-A62V-01A_CLTC_chr17_57746301_+_RPS6KB1_chr17_57987923_length(amino acids)=1219AA_start in transcript=274_stop in transcript=3933
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFEL
LRVLGKGGYGKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMAL
GHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGE
NRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKF
TRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPM

--------------------------------------------------------------
>In-frame_ENST00000269122_ENST00000406116_TCGA-AC-A62V-01A_CLTC_chr17_57746301_+_RPS6KB1_chr17_57987923_length(transcript)=4367nt_BP=2566nt
GGCGGAGTTCTGTCGCCGGGATCCTTCCGCTGGGCTCAGCCGTTTCCGGAGTCTGCGCTGCGCCCGGTTCCGCCATTGCGGCTCTCCTGG
CCCCTGGAGCCTCCGCCCCCGACCCGAGCTCTTTCGTCTGCCTGCCAGTTTCCTGCGTCCCCGGAGAGGATCCTGCTGAGCCCAGCCTCC
CCCCTCCCCTTCTCCTCCTCTCCCTTGGAGAGCCCGGGCAGCCACTGCCCCGCAGCCCCAGTGACAGGAGGAGACCATAACCCCCGACAG
CGCCATGGCCCAGATTCTGCCAATTCGTTTTCAGGAGCATCTCCAGCTCCAGAACCTGGGTATCAACCCAGCAAACATTGGCTTCAGTAC
CCTGACTATGGAGTCTGACAAATTCATCTGCATTAGAGAAAAAGTAGGAGAGCAGGCCCAGGTGGTAATCATTGATATGAATGACCCAAG
TAATCCAATTCGAAGACCAATTTCAGCAGACAGCGCCATCATGAATCCAGCTAGCAAAGTAATTGCACTGAAAGCTGGGAAAACTCTTCA
GATTTTTAACATTGAAATGAAAAGTAAAATGAAGGCTCATACCATGACTGATGATGTCACCTTTTGGAAATGGATCTCTTTGAATACGGT
TGCTCTTGTTACGGATAATGCAGTTTATCACTGGAGTATGGAAGGAGAGTCTCAGCCAGTGAAAATGTTTGATCGCCATTCTAGCCTTGC
AGGGTGCCAGATTATCAATTACCGTACAGATGCAAAACAAAAGTGGTTACTTCTGACTGGTATATCTGCACAGCAAAATCGTGTGGTGGG
AGCTATGCAGCTATATTCTGTAGATAGGAAAGTGTCTCAGCCCATTGAAGGACATGCAGCTAGCTTTGCACAGTTTAAGATGGAAGGAAA
TGCAGAAGAATCAACGTTATTTTGTTTTGCAGTTCGGGGCCAAGCTGGAGGGAAGTTACATATTATTGAAGTTGGCACACCACCTACAGG
GAACCAGCCCTTTCCAAAGAAGGCAGTGGATGTCTTCTTTCCTCCAGAAGCACAAAATGATTTTCCTGTTGCAATGCAGATCAGTGAAAA
GCATGATGTGGTGTTCTTGATAACCAAGTATGGTTATATCCACCTCTATGATCTTGAGACTGGTACCTGCATCTACATGAATAGAATCAG
TGGAGAAACAATTTTTGTTACTGCACCTCATGAAGCCACAGCTGGAATAATTGGAGTAAACAGAAAGGGACAAGTTCTGTCAGTGTGTGT
GGAAGAAGAAAACATAATTCCTTACATCACCAATGTTCTACAAAATCCTGATTTGGCTCTGAGAATGGCTGTACGTAATAACTTAGCCGG
TGCTGAAGAACTCTTTGCCCGGAAATTTAATGCTCTTTTTGCCCAGGGAAATTACTCGGAGGCAGCAAAGGTGGCTGCTAATGCACCAAA
GGGAATTCTTCGTACTCCAGACACTATCCGTCGGTTCCAGAGTGTCCCAGCCCAGCCAGGTCAAACTTCTCCTCTACTTCAGTACTTTGG
TATCCTTTTGGACCAGGGACAGCTCAACAAATACGAATCCTTAGAGCTTTGTAGGCCTGTACTTCAGCAAGGGCGAAAACAGCTTTTGGA
GAAATGGTTAAAAGAAGATAAGCTGGAATGTTCTGAAGAACTGGGTGATCTTGTGAAATCTGTGGACCCTACATTGGCACTTAGTGTGTA
CCTAAGGGCTAACGTCCCAAATAAAGTCATTCAGTGCTTTGCAGAAACAGGTCAAGTCCAAAAGATTGTTTTATATGCTAAAAAAGTTGG
ATACACTCCAGATTGGATATTTCTGCTGAGAAATGTAATGCGAATCAGTCCAGATCAGGGACAGCAGTTTGCCCAAATGTTAGTTCAAGA
TGAAGAGCCTCTTGCTGACATCACACAGATTGTAGATGTCTTTATGGAATACAATCTAATTCAGCAGTGTACTGCATTCTTGCTTGATGC
TCTGAAGAATAATCGCCCATCTGAAGGTCCTTTACAGACGCGGTTACTTGAGATGAACCTTATGCATGCGCCTCAAGTTGCAGATGCTAT
TCTAGGCAATCAGATGTTCACACATTATGACCGGGCTCATATTGCTCAACTGTGTGAAAAGGCTGGCCTACTGCAGCGTGCATTAGAACA
TTTCACTGATTTATATGATATAAAACGTGCAGTGGTTCACACCCATCTTCTTAACCCTGAGTGGTTAGTCAACTACTTTGGTTCCTTATC
AGTAGAAGACTCCCTAGAATGTCTCAGAGCCATGCTGTCTGCCAACATCCGTCAGAATCTGCAGATTTGTGTTCAGGTGGCTTCTAAATA
TCATGAACAACTGTCAACTCAGTCTCTGATTGAACTTTTTGAATCTTTCAAGAGTTTTGAAGGTCTCTTTTATTTTCTGGGATCCATTGT
TAACTTTAGCCAGGACCCAGATGTGCACTTTAAATATATTCAGGCAGCTTGCAAGACTGGGCAAATCAAAGAAGTAGAAAGAATCTGTAG
AGAAAGCAACTGCTACGATCCTGAGCGAGTCAAGAATTTTCTTAAGGGTCAGTTAAATGAAAGCATGGACCATGGGGGAGTTGGACCATA
TGAACTTGGCATGGAACATTGTGAGAAATTTGAAATCTCAGAAACTAGTGTGAACAGAGGGCCAGAAAAAATCAGACCAGAATGTTTTGA
GCTACTTCGGGTACTTGGTAAAGGGGGCTATGGAAAGGTTTTTCAAGTACGAAAAGTAACAGGAGCAAATACTGGGAAAATATTTGCCAT
GAAGGTGCTTAAAAAGGCAATGATAGTAAGAAATGCTAAAGATACAGCTCATACAAAAGCAGAACGGAATATTCTGGAGGAAGTAAAGCA
TCCCTTCATCGTGGATTTAATTTATGCCTTTCAGACTGGTGGAAAACTCTACCTCATCCTTGAGTATCTCAGTGGAGGAGAACTATTTAT
GCAGTTAGAAAGAGAGGGAATATTTATGGAAGACACTGCCTGCTTTTACTTGGCAGAAATCTCCATGGCTTTGGGGCATTTACATCAAAA
GGGGATCATCTACAGAGACCTGAAGCCGGAGAATATCATGCTTAATCACCAAGGTCATGTGAAACTAACAGACTTTGGACTATGCAAAGA
ATCTATTCATGATGGAACAGTCACACACACATTTTGTGGAACAATAGAATACATGGCCCCTGAAATCTTGATGAGAAGTGGCCACAATCG
TGCTGTGGATTGGTGGAGTTTGGGAGCATTAATGTATGACATGCTGACTGGAGCACCCCCATTCACTGGGGAGAATAGAAAGAAAACAAT
TGACAAAATCCTCAAATGTAAACTCAATTTGCCTCCCTACCTCACACAAGAAGCCAGAGATCTGCTTAAAAAGCTGCTGAAAAGAAATGC
TGCTTCTCGTCTGGGAGCTGGTCCTGGGGACGCTGGAGAAGTTCAAGCTCATCCATTCTTTAGACACATTAACTGGGAAGAACTTCTGGC
TCGAAAGGTGGAGCCCCCCTTTAAACCTCTGTTGCAATCTGAAGAGGATGTAAGTCAGTTTGATTCCAAGTTTACACGTCAGACACCTGT
CGACAGCCCAGATGACTCAACTCTCAGTGAAAGTGCCAATCAGGTCTTTCTGGGTTTTACATATGTGGCTCCATCTGTACTTGAAAGTGT
GAAAGAAAAGTTTTCCTTTGAACCAAAAATCCGATCACCTCGAAGATTTATTGGCAGCCCACGAACACCTGTCAGTACTGCTATGTGCTA
AGCTTAACTGGAAGCCTTGGAATGGGCATAAGTTGTATGTCCTACATTTCATCATTGTCCCGGGCCTGCATTGCACTGGAAAAAAAAATC
GCCACCTGTTCTTACACCAGTATTTGGTTCAAGACACCAAATGTCTTCAGCCCATGGCTGAAGAACAACAGAAGAGAGTCAGGATAAAAA
ATACATACTGTGGTCGGCAAGGTGAGGGAGATAGGGATATCCAGGGGAAGAGGGTGTTGCTGTGGCCCACTCTCTGTCTAATCTCTTTAC
AGCAAATTGGTAAGATTTTCAGTTTTACTTCTTTCTACTGTTTCTGCTGTCTACCTTCCTTATATTTTTTTCCTCAACAGTTTTAAAAAG
AAAAAAAGGTCTATTTTTTTTTCTCCTATACTTGGGCTACATTTTTTGATTGTAAAAATATTTGATGGCCTTTTGATGAATGTCTTCCAC
AGTAAAGAAAACTTAGTGGCTTAATTTAGGAAACATGTTAACAGGACACTATGTTTTTGAAATTGTAACAAAATCTACATAAATGATTTA

>In-frame_ENST00000269122_ENST00000406116_TCGA-AC-A62V-01A_CLTC_chr17_57746301_+_RPS6KB1_chr17_57987923_length(amino acids)=1168AA_start in transcript=274_stop in transcript=3780
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFEL
LRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQ
LEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRA
VDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLAR

--------------------------------------------------------------
>In-frame_ENST00000269122_ENST00000225577_TCGA-AC-A62V-01A_CLTC_chr17_57746301_+_RPS6KB1_chr17_57987923_length(transcript)=7779nt_BP=2566nt
GGCGGAGTTCTGTCGCCGGGATCCTTCCGCTGGGCTCAGCCGTTTCCGGAGTCTGCGCTGCGCCCGGTTCCGCCATTGCGGCTCTCCTGG
CCCCTGGAGCCTCCGCCCCCGACCCGAGCTCTTTCGTCTGCCTGCCAGTTTCCTGCGTCCCCGGAGAGGATCCTGCTGAGCCCAGCCTCC
CCCCTCCCCTTCTCCTCCTCTCCCTTGGAGAGCCCGGGCAGCCACTGCCCCGCAGCCCCAGTGACAGGAGGAGACCATAACCCCCGACAG
CGCCATGGCCCAGATTCTGCCAATTCGTTTTCAGGAGCATCTCCAGCTCCAGAACCTGGGTATCAACCCAGCAAACATTGGCTTCAGTAC
CCTGACTATGGAGTCTGACAAATTCATCTGCATTAGAGAAAAAGTAGGAGAGCAGGCCCAGGTGGTAATCATTGATATGAATGACCCAAG
TAATCCAATTCGAAGACCAATTTCAGCAGACAGCGCCATCATGAATCCAGCTAGCAAAGTAATTGCACTGAAAGCTGGGAAAACTCTTCA
GATTTTTAACATTGAAATGAAAAGTAAAATGAAGGCTCATACCATGACTGATGATGTCACCTTTTGGAAATGGATCTCTTTGAATACGGT
TGCTCTTGTTACGGATAATGCAGTTTATCACTGGAGTATGGAAGGAGAGTCTCAGCCAGTGAAAATGTTTGATCGCCATTCTAGCCTTGC
AGGGTGCCAGATTATCAATTACCGTACAGATGCAAAACAAAAGTGGTTACTTCTGACTGGTATATCTGCACAGCAAAATCGTGTGGTGGG
AGCTATGCAGCTATATTCTGTAGATAGGAAAGTGTCTCAGCCCATTGAAGGACATGCAGCTAGCTTTGCACAGTTTAAGATGGAAGGAAA
TGCAGAAGAATCAACGTTATTTTGTTTTGCAGTTCGGGGCCAAGCTGGAGGGAAGTTACATATTATTGAAGTTGGCACACCACCTACAGG
GAACCAGCCCTTTCCAAAGAAGGCAGTGGATGTCTTCTTTCCTCCAGAAGCACAAAATGATTTTCCTGTTGCAATGCAGATCAGTGAAAA
GCATGATGTGGTGTTCTTGATAACCAAGTATGGTTATATCCACCTCTATGATCTTGAGACTGGTACCTGCATCTACATGAATAGAATCAG
TGGAGAAACAATTTTTGTTACTGCACCTCATGAAGCCACAGCTGGAATAATTGGAGTAAACAGAAAGGGACAAGTTCTGTCAGTGTGTGT
GGAAGAAGAAAACATAATTCCTTACATCACCAATGTTCTACAAAATCCTGATTTGGCTCTGAGAATGGCTGTACGTAATAACTTAGCCGG
TGCTGAAGAACTCTTTGCCCGGAAATTTAATGCTCTTTTTGCCCAGGGAAATTACTCGGAGGCAGCAAAGGTGGCTGCTAATGCACCAAA
GGGAATTCTTCGTACTCCAGACACTATCCGTCGGTTCCAGAGTGTCCCAGCCCAGCCAGGTCAAACTTCTCCTCTACTTCAGTACTTTGG
TATCCTTTTGGACCAGGGACAGCTCAACAAATACGAATCCTTAGAGCTTTGTAGGCCTGTACTTCAGCAAGGGCGAAAACAGCTTTTGGA
GAAATGGTTAAAAGAAGATAAGCTGGAATGTTCTGAAGAACTGGGTGATCTTGTGAAATCTGTGGACCCTACATTGGCACTTAGTGTGTA
CCTAAGGGCTAACGTCCCAAATAAAGTCATTCAGTGCTTTGCAGAAACAGGTCAAGTCCAAAAGATTGTTTTATATGCTAAAAAAGTTGG
ATACACTCCAGATTGGATATTTCTGCTGAGAAATGTAATGCGAATCAGTCCAGATCAGGGACAGCAGTTTGCCCAAATGTTAGTTCAAGA
TGAAGAGCCTCTTGCTGACATCACACAGATTGTAGATGTCTTTATGGAATACAATCTAATTCAGCAGTGTACTGCATTCTTGCTTGATGC
TCTGAAGAATAATCGCCCATCTGAAGGTCCTTTACAGACGCGGTTACTTGAGATGAACCTTATGCATGCGCCTCAAGTTGCAGATGCTAT
TCTAGGCAATCAGATGTTCACACATTATGACCGGGCTCATATTGCTCAACTGTGTGAAAAGGCTGGCCTACTGCAGCGTGCATTAGAACA
TTTCACTGATTTATATGATATAAAACGTGCAGTGGTTCACACCCATCTTCTTAACCCTGAGTGGTTAGTCAACTACTTTGGTTCCTTATC
AGTAGAAGACTCCCTAGAATGTCTCAGAGCCATGCTGTCTGCCAACATCCGTCAGAATCTGCAGATTTGTGTTCAGGTGGCTTCTAAATA
TCATGAACAACTGTCAACTCAGTCTCTGATTGAACTTTTTGAATCTTTCAAGAGTTTTGAAGGTCTCTTTTATTTTCTGGGATCCATTGT
TAACTTTAGCCAGGACCCAGATGTGCACTTTAAATATATTCAGGCAGCTTGCAAGACTGGGCAAATCAAAGAAGTAGAAAGAATCTGTAG
AGAAAGCAACTGCTACGATCCTGAGCGAGTCAAGAATTTTCTTAAGGGTCAGTTAAATGAAAGCATGGACCATGGGGGAGTTGGACCATA
TGAACTTGGCATGGAACATTGTGAGAAATTTGAAATCTCAGAAACTAGTGTGAACAGAGGGCCAGAAAAAATCAGACCAGAATGTTTTGA
GCTACTTCGGGTACTTGGTAAAGGGGGCTATGGAAAGGTTTTTCAAGTACGAAAAGTAACAGGAGCAAATACTGGGAAAATATTTGCCAT
GAAGGTGCTTAAAAAGGCAATGATAGTAAGAAATGCTAAAGATACAGCTCATACAAAAGCAGAACGGAATATTCTGGAGGAAGTAAAGCA
TCCCTTCATCGTGGATTTAATTTATGCCTTTCAGACTGGTGGAAAACTCTACCTCATCCTTGAGTATCTCAGTGGAGGAGAACTATTTAT
GCAGTTAGAAAGAGAGGGAATATTTATGGAAGACACTGCCTGCTTTTACTTGGCAGAAATCTCCATGGCTTTGGGGCATTTACATCAAAA
GGGGATCATCTACAGAGACCTGAAGCCGGAGAATATCATGCTTAATCACCAAGGTCATGTGAAACTAACAGACTTTGGACTATGCAAAGA
ATCTATTCATGATGGAACAGTCACACACACATTTTGTGGAACAATAGAATACATGGCCCCTGAAATCTTGATGAGAAGTGGCCACAATCG
TGCTGTGGATTGGTGGAGTTTGGGAGCATTAATGTATGACATGCTGACTGGAGCACCCCCATTCACTGGGGAGAATAGAAAGAAAACAAT
TGACAAAATCCTCAAATGTAAACTCAATTTGCCTCCCTACCTCACACAAGAAGCCAGAGATCTGCTTAAAAAGCTGCTGAAAAGAAATGC
TGCTTCTCGTCTGGGAGCTGGTCCTGGGGACGCTGGAGAAGTTCAAGCTCATCCATTCTTTAGACACATTAACTGGGAAGAACTTCTGGC
TCGAAAGGTGGAGCCCCCCTTTAAACCTCTGTTGCAATCTGAAGAGGATGTAAGTCAGTTTGATTCCAAGTTTACACGTCAGACACCTGT
CGACAGCCCAGATGACTCAACTCTCAGTGAAAGTGCCAATCAGGTCTTTCTGGGTTTTACATATGTGGCTCCATCTGTACTTGAAAGTGT
GAAAGAAAAGTTTTCCTTTGAACCAAAAATCCGATCACCTCGAAGATTTATTGGCAGCCCACGAACACCTGTCAGCCCAGTCAAATTTTC
TCCTGGGGATTTCTGGGGAAGAGGTGCTTCGGCCAGCACAGCAAATCCTCAGACACCTGTGGAATACCCAATGGAAACAAGTGGCATAGA
GCAGATGGATGTGACAATGAGTGGGGAAGCATCGGCACCACTTCCAATACGACAGCCGAACTCTGGGCCATACAAAAAACAAGCTTTTCC
CATGATCTCCAAACGGCCAGAGCACCTGCGTATGAATCTATGACAGAGCAATGCTTTTAATGAATTTAAGGCAAAAAAGGTGGAGAGGGA
GATGTGTGAGCATCCTGCAAGGTGAAACGACTCAAAATGACAGTTTCAGAGAGTCAATGTCATTACATAGAACACTTCAGACACAGGAAA
AATAAACGTGGATTTTAAAAAATCAATCAATGGTGCAAAAAAAAACTTAAAGCAAAATAGTATTGCTGAACTCTTAGGCACATCAATTAA
TTGATTCCTCGCGACATCTTCTCAACCTTATCAAGGATTTTCATGTTGATGACTCGAAACTGACAGTATTAAGGGTAGGATGTTGCTTCT
GAATCACTGTTGAGTTCTGATTGTGTTGAAGAAGGGTTATCCTTTCATTAGGCAAAGTACAAAATTGCCTATAATACTTGCAACTAAGGA
CAAATTAGCATGCAAGCTTGGTCAAACTTTTTCCAGCAAAATGGAAGCAAAGACAAAAGAAACTTACCAATTGATGTTTTACGTGCAAAC
AACCTGAATCTTTTTTTTATATAAATATATATTTTTCAAATAGATTTTTGATTCAGCTCATTATGAAAAACATCCCAAACTTTAAAATGC
GAAATTATTGGTTGGTGTGAAGAAAGCCAGACAACTTCTGTTTCTTCTCTTGGTGAAATAATAAAATGCAAATGAATCATTGTTAACCAC
AGCTGTGGCTCGTTTGAGGGATTGGGGTGGACCTGGGGTTTATTTTCAGTAACCCAGCTGCAATACCTGTCTGTAATATGAGAAAAAAAA
AATGAATCTATTTAATCATTTCTACTTGCAGTACTGCTATGTGCTAAGCTTAACTGGAAGCCTTGGAATGGGCATAAGTTGTATGTCCTA
CATTTCATCATTGTCCCGGGCCTGCATTGCACTGGAAAAAAAAATCGCCACCTGTTCTTACACCAGTATTTGGTTCAAGACACCAAATGT
CTTCAGCCCATGGCTGAAGAACAACAGAAGAGAGTCAGGATAAAAAATACATACTGTGGTCGGCAAGGTGAGGGAGATAGGGATATCCAG
GGGAAGAGGGTGTTGCTGTGGCCCACTCTCTGTCTAATCTCTTTACAGCAAATTGGTAAGATTTTCAGTTTTACTTCTTTCTACTGTTTC
TGCTGTCTACCTTCCTTATATTTTTTTCCTCAACAGTTTTAAAAAGAAAAAAAGGTCTATTTTTTTTTCTCCTATACTTGGGCTACATTT
TTTGATTGTAAAAATATTTGATGGCCTTTTGATGAATGTCTTCCACAGTAAAGAAAACTTAGTGGCTTAATTTAGGAAACATGTTAACAG
GACACTATGTTTTTGAAATTGTAACAAAATCTACATAAATGATTTACAGGTTAAAAGAATAAAAATAAAGGTAACTTTACCTTTCTTAAA
TATTTCCTGCCTTAAAGAGAGCATTTCCATGACTTTAGCTGGTGAAAGGGTTTAATATCTGCAGAGCTTTATAAAAATATATTTCAGTGC
ATACTGGTATAATAGATGATCATGCAGTTGCAGTTGAGTTGTATCACCTTTTTTGTTTGTCTTTTATAATGTCTTCAGTCTGAGTGTGCA
AAGTCAATTTGTAATATTTTGCAACCCTAGGATTTTTTTAAATAGATGCTGCTTGCTATGTTTTCAAACCTTTTTGAGCCATAGGATCCA
AGCCATAAAATTCTTTATGCATGTTGAATTCAGTCAGAAAAGAGCAAGGCTTTGCTTTTTGAAATTGCAACTCAAATGAGATGGGATGAA
ATCCTATGACAGTAAGCAAAAACAGAACCATGAAAAATGATTGGACATACACCTTTTCAATTGTGGCAATAATTGAAAGAATCGATAAAA
GTTCATCTTTGGACAGAAAGCCTTTAAAAAAAAAATCACTCCCTCTTCCCCCTCCTCCCTTATTGCAGCAGCCTACTGAGAACTTTGACT
GTTGCTGGTAAATTAGAAGCTACAATAATAATTAAGGGCAGAAATTATACTTAAAAAGTGCAGATCCTTGTTCTTTGACAATTTGTGATG
TCTGAAAAAACAGAACCCGAAAAGCTATGGTGATATGTACAGGCATTATTTCAGACTGTAAATGGCTTGTGATACTCTTGATACTTGTTT
TCAAATATGTTTACTAACTGTAGTGTTGACTGCCTGACCAAATTCCAGTGAAACTTATACACCAAAATATTCTTCCTAGGTCCTATTTGC
TAGTAACATGAGCACTGTGATTGGCTGGCTATAACCACCCCAGTTAAACCATTTTCATAATTAGTAGTGCCAGCAATAGTGGCAAACACT
GCAACTTTTCTGCATAAAAAGCATTAATTGCACAGCTACCATCCACACAAATACATAGTTTTTCTGACTTCACATTTATTAAGTGAAATT
TATTTCCCATGCTGTGGAAAGTTTATTGAGAACTTGTTTCATAAATGGATATCCCTACTATGACTGTGAAAACATGTCAAGTGTCACATT
AGTGTCACAGACAGAAAGCACACACCTATGCAATATGGCTTATCTATATTTATTTGTAAAAATCCAAGCATAGTTTAAAATATGATGTCG
ATATTACTAGTCTTGAGTTTCTAAGAGGGTTCTTTATGTTATACCAGGTAAGTGTATAAAAGAGATTAAGTGCTTTTTTTTCATCACTTG
ATTATTTTCTTTAAAATCAGCTATTACAGGATATTTTTTTATTTTATACATGCTGTTTTTTAATTAAAATATAATCACTGAAGTTTACTA
ATTTGATTTTATAAGGTTTGTAGCATTACAGAATAACTAAACTGGGATTTATAAACCAGCTGTGATTAACAATGTAAAGTATTAATTATT
GAACTTTGAACCAGATTTTTAGGAAAATTATGTTCTTTTTCCCCCTTTATGGTCTTAACTAATTTGAATCCTTCAAGAAGGATTTTTCCA
TACTATTTTTTAAGATAGAAGATAATTTGTGGGCAGGGGTGGAGGATGCATGTATGATACTCCATAAATTCAACATTCTTTACTATAGGT
AATGAATGATTATAAACAAGATGCATCTTAGATAGTATTAATATACTGAGCCTTGGATTATATATTTAATATAGGACCTATTTTGAATAT
TCAGTTAATCATATGGTTCCTAGCTTACAAGGGCTAGATCTAAGATTATTCCCATGAGAAATGTTGAATTTATGAAGAATAGATTTTAAG
GCTTTGAAAATGGTTAATTTCTCAAAAACATCAATGTCCAAACATCTACCTTTTTTCATAGGAGTAGACACTAGCAAGCTGGACAAACTA
TCACAAAAGTATTTGTCACACATAACCTGTGGTCTGTTGCTGATTAATACAGTACTTTTTCTTGTGTGATTCTTAACATTATAGCACAAG
TATTATCTCAGTGGATTATCCGGAATAACATCTGAAAGATGGGTTCATCTATGTTTGTGTTTGCTCTTTAAACTATTGTTTCTCCTATCC
CAAGTTCGCTTTGCATCTATCAGTAAATAAAATTCTTCAGCTGCCTTATTAGGAGTGCTATGAGGGTAACACCTGTTCTGCTTTTCATCT
TGTATTTAGTTGACTGTATTATTTGATTTCGGATTGAATGAATGTAAATAGAAATTAAATGCAAATTTGAATGAACATAAATAGAAGTGA
TTTATTTTTTTATTATCTTAAAGATAGGAAGGAATTAGTATACGTATCAGGTGTATAAATGGTTTAAATTTATTTTAACATGTCAGATGT

>In-frame_ENST00000269122_ENST00000225577_TCGA-AC-A62V-01A_CLTC_chr17_57746301_+_RPS6KB1_chr17_57987923_length(amino acids)=1242AA_start in transcript=274_stop in transcript=4002
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQI
FNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGA
MQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKH
DVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGA
EELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEK
WLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDE
EPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHF
TDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVN
FSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFEL
LRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQ
LEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRA
VDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLAR
KVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CLTC-RPS6KB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CLTC-RPS6KB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CLTC-RPS6KB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLTCC4518356MiT family translocation renal cell carcinoma2ORPHANET
HgeneCLTCC4693389MENTAL RETARDATION, AUTOSOMAL DOMINANT 562GENOMICS_ENGLAND;UNIPROT
HgeneCLTCC0079744Diffuse Large B-Cell Lymphoma1CTD_human
HgeneCLTCC0334121Inflammatory Myofibroblastic Tumor1ORPHANET
TgeneRPS6KB1C0020538Hypertensive disease1CTD_human
TgeneRPS6KB1C0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneRPS6KB1C0149721Left Ventricular Hypertrophy1CTD_human
TgeneRPS6KB1C0333641Atrophic1CTD_human
TgeneRPS6KB1C2931673Ceroid lipofuscinosis, neuronal 1, infantile1CTD_human