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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CLU-CLU (FusionGDB2 ID:17445)

Fusion Gene Summary for CLU-CLU

check button Fusion gene summary
Fusion gene informationFusion gene name: CLU-CLU
Fusion gene ID: 17445
HgeneTgene
Gene symbol

CLU

CLU

Gene ID

1191

1191

Gene nameclusterinclusterin
SynonymsAAG4|APO-J|APOJ|CLI|CLU1|CLU2|KUB1|NA1/NA2|SGP-2|SGP2|SP-40|TRPM-2|TRPM2AAG4|APO-J|APOJ|CLI|CLU1|CLU2|KUB1|NA1/NA2|SGP-2|SGP2|SP-40|TRPM-2|TRPM2
Cytomap

8p21.1

8p21.1

Type of geneprotein-codingprotein-coding
Descriptionclusterinaging-associated protein 4apolipoprotein Jcomplement cytolysis inhibitorcomplement lysis inhibitorcomplement-associated protein SP-40,40epididymis secretory sperm binding proteinku70-binding protein 1sulfated glycoprotein 2testosterone-rclusterinaging-associated protein 4apolipoprotein Jcomplement cytolysis inhibitorcomplement lysis inhibitorcomplement-associated protein SP-40,40epididymis secretory sperm binding proteinku70-binding protein 1sulfated glycoprotein 2testosterone-r
Modification date2020032720200327
UniProtAcc

P10909

Q15846

Ensembl transtripts involved in fusion geneENST00000316403, ENST00000546343, 
ENST00000560366, ENST00000405140, 
ENST00000523500, 		ENST00000316403, 
ENST00000546343, ENST00000560366, 
ENST00000405140, ENST00000523500, 
Fusion gene scores* DoF score38 X 38 X 12=1732823 X 24 X 12=6624
# samples 4930
** MAII scorelog2(49/17328*10)=-5.14417958860576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/6624*10)=-4.46466826700344
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLU [Title/Abstract] AND CLU [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLU(27455762)-CLU(27462623), # samples:1
CLU(27455687)-CLU(27455753), # samples:1
CLU(27457330)-CLU(27456084), # samples:1
CLU(27466459)-CLU(27462611), # samples:1
CLU(27457324)-CLU(27468826), # samples:1
Anticipated loss of major functional domain due to fusion event.CLU-CLU seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CLU-CLU seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLU

GO:0000902

cell morphogenesis

15857407

HgeneCLU

GO:0001774

microglial cell activation

15857407

HgeneCLU

GO:0017038

protein import

24446231

HgeneCLU

GO:0031333

negative regulation of protein complex assembly

22179788|23106396

HgeneCLU

GO:0031334

positive regulation of protein complex assembly

22179788

HgeneCLU

GO:0032760

positive regulation of tumor necrosis factor production

15857407

HgeneCLU

GO:0045429

positive regulation of nitric oxide biosynthetic process

15857407

HgeneCLU

GO:0050821

protein stabilization

11123922|12176985

HgeneCLU

GO:0051131

chaperone-mediated protein complex assembly

17412999

HgeneCLU

GO:0051788

response to misfolded protein

19996109

HgeneCLU

GO:0061077

chaperone-mediated protein folding

11123922

HgeneCLU

GO:0061518

microglial cell proliferation

15857407

HgeneCLU

GO:1900221

regulation of amyloid-beta clearance

24446231

HgeneCLU

GO:1901214

regulation of neuron death

17412999

HgeneCLU

GO:1901216

positive regulation of neuron death

15857407

HgeneCLU

GO:1902430

negative regulation of amyloid-beta formation

12047389|17412999

HgeneCLU

GO:1905907

negative regulation of amyloid fibril formation

22179788

TgeneCLU

GO:0000902

cell morphogenesis

15857407

TgeneCLU

GO:0001774

microglial cell activation

15857407

TgeneCLU

GO:0017038

protein import

24446231

TgeneCLU

GO:0031333

negative regulation of protein complex assembly

22179788|23106396

TgeneCLU

GO:0031334

positive regulation of protein complex assembly

22179788

TgeneCLU

GO:0032760

positive regulation of tumor necrosis factor production

15857407

TgeneCLU

GO:0045429

positive regulation of nitric oxide biosynthetic process

15857407

TgeneCLU

GO:0050821

protein stabilization

11123922|12176985

TgeneCLU

GO:0051131

chaperone-mediated protein complex assembly

17412999

TgeneCLU

GO:0051788

response to misfolded protein

19996109

TgeneCLU

GO:0061077

chaperone-mediated protein folding

11123922

TgeneCLU

GO:0061518

microglial cell proliferation

15857407

TgeneCLU

GO:1900221

regulation of amyloid-beta clearance

24446231

TgeneCLU

GO:1901214

regulation of neuron death

17412999

TgeneCLU

GO:1901216

positive regulation of neuron death

15857407

TgeneCLU

GO:1902430

negative regulation of amyloid-beta formation

12047389|17412999

TgeneCLU

GO:1905907

negative regulation of amyloid fibril formation

22179788


check buttonFusion gene breakpoints across CLU (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CLU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA291054CLUchr8

27455762

+CLUchr8

27462623

-
ChiTaRS5.0N/AAW516531CLUchr8

27455687

+CLUchr8

27455753

-
ChiTaRS5.0N/ABG896922CLUchr8

27457330

+CLUchr8

27456084

-
ChiTaRS5.0N/ABI016129CLUchr8

27466459

-CLUchr8

27462611

+
ChiTaRS5.0N/ABP348657CLUchr8

27457324

-CLUchr8

27468826

-


Top

Fusion Gene ORF analysis for CLU-CLU

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000316403ENST00000316403CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000316403ENST00000546343CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000316403ENST00000560366CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000316403ENST00000405140CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000316403ENST00000523500CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000546343ENST00000316403CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000546343ENST00000546343CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000546343ENST00000560366CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000546343ENST00000405140CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000546343ENST00000523500CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000560366ENST00000316403CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000560366ENST00000546343CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000560366ENST00000560366CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000560366ENST00000405140CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000560366ENST00000523500CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000405140ENST00000316403CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000405140ENST00000546343CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000405140ENST00000560366CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000405140ENST00000405140CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000405140ENST00000523500CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000523500ENST00000316403CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000523500ENST00000546343CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000523500ENST00000560366CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000523500ENST00000405140CLUchr8

27455762

+CLUchr8

27462623

-
intron-3CDSENST00000523500ENST00000523500CLUchr8

27455762

+CLUchr8

27462623

-
intron-3UTRENST00000316403ENST00000316403CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000316403ENST00000546343CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000316403ENST00000560366CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000316403ENST00000405140CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000316403ENST00000523500CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000546343ENST00000316403CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000546343ENST00000546343CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000546343ENST00000560366CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000546343ENST00000405140CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000546343ENST00000523500CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000560366ENST00000316403CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000560366ENST00000546343CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000560366ENST00000560366CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000560366ENST00000405140CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000560366ENST00000523500CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000405140ENST00000316403CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000405140ENST00000546343CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000405140ENST00000560366CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000405140ENST00000405140CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000405140ENST00000523500CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000523500ENST00000316403CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000523500ENST00000546343CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000523500ENST00000560366CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000523500ENST00000405140CLUchr8

27455687

+CLUchr8

27455753

-
intron-3UTRENST00000523500ENST00000523500CLUchr8

27455687

+CLUchr8

27455753

-
intron-3CDSENST00000316403ENST00000316403CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000316403ENST00000546343CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000316403ENST00000560366CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000316403ENST00000405140CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000316403ENST00000523500CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000546343ENST00000316403CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000546343ENST00000546343CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000546343ENST00000560366CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000546343ENST00000405140CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000546343ENST00000523500CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000560366ENST00000316403CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000560366ENST00000546343CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000560366ENST00000560366CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000560366ENST00000405140CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000560366ENST00000523500CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000405140ENST00000316403CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000405140ENST00000546343CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000405140ENST00000560366CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000405140ENST00000405140CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000405140ENST00000523500CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000523500ENST00000316403CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000523500ENST00000546343CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000523500ENST00000560366CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000523500ENST00000405140CLUchr8

27457330

+CLUchr8

27456084

-
intron-3CDSENST00000523500ENST00000523500CLUchr8

27457330

+CLUchr8

27456084

-
Frame-shiftENST00000316403ENST00000316403CLUchr8

27466459

-CLUchr8

27462611

+
Frame-shiftENST00000316403ENST00000546343CLUchr8

27466459

-CLUchr8

27462611

+
Frame-shiftENST00000316403ENST00000560366CLUchr8

27466459

-CLUchr8

27462611

+
Frame-shiftENST00000316403ENST00000405140CLUchr8

27466459

-CLUchr8

27462611

+
Frame-shiftENST00000316403ENST00000523500CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000546343ENST00000316403CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000546343ENST00000546343CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000546343ENST00000560366CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000546343ENST00000405140CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000546343ENST00000523500CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000560366ENST00000316403CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000560366ENST00000546343CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000560366ENST00000560366CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000560366ENST00000405140CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000560366ENST00000523500CLUchr8

27466459

-CLUchr8

27462611

+
Frame-shiftENST00000405140ENST00000316403CLUchr8

27466459

-CLUchr8

27462611

+
Frame-shiftENST00000405140ENST00000546343CLUchr8

27466459

-CLUchr8

27462611

+
Frame-shiftENST00000405140ENST00000560366CLUchr8

27466459

-CLUchr8

27462611

+
Frame-shiftENST00000405140ENST00000405140CLUchr8

27466459

-CLUchr8

27462611

+
Frame-shiftENST00000405140ENST00000523500CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000523500ENST00000316403CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000523500ENST00000546343CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000523500ENST00000560366CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000523500ENST00000405140CLUchr8

27466459

-CLUchr8

27462611

+
In-frameENST00000523500ENST00000523500CLUchr8

27466459

-CLUchr8

27462611

+
intron-intronENST00000316403ENST00000316403CLUchr8

27457324

-CLUchr8

27468826

-
intron-intronENST00000316403ENST00000546343CLUchr8

27457324

-CLUchr8

27468826

-
intron-intronENST00000316403ENST00000560366CLUchr8

27457324

-CLUchr8

27468826

-
intron-5UTRENST00000316403ENST00000405140CLUchr8

27457324

-CLUchr8

27468826

-
intron-5UTRENST00000316403ENST00000523500CLUchr8

27457324

-CLUchr8

27468826

-
intron-intronENST00000546343ENST00000316403CLUchr8

27457324

-CLUchr8

27468826

-
intron-intronENST00000546343ENST00000546343CLUchr8

27457324

-CLUchr8

27468826

-
intron-intronENST00000546343ENST00000560366CLUchr8

27457324

-CLUchr8

27468826

-
intron-5UTRENST00000546343ENST00000405140CLUchr8

27457324

-CLUchr8

27468826

-
intron-5UTRENST00000546343ENST00000523500CLUchr8

27457324

-CLUchr8

27468826

-
intron-intronENST00000560366ENST00000316403CLUchr8

27457324

-CLUchr8

27468826

-
intron-intronENST00000560366ENST00000546343CLUchr8

27457324

-CLUchr8

27468826

-
intron-intronENST00000560366ENST00000560366CLUchr8

27457324

-CLUchr8

27468826

-
intron-5UTRENST00000560366ENST00000405140CLUchr8

27457324

-CLUchr8

27468826

-
intron-5UTRENST00000560366ENST00000523500CLUchr8

27457324

-CLUchr8

27468826

-
intron-intronENST00000405140ENST00000316403CLUchr8

27457324

-CLUchr8

27468826

-
intron-intronENST00000405140ENST00000546343CLUchr8

27457324

-CLUchr8

27468826

-
intron-intronENST00000405140ENST00000560366CLUchr8

27457324

-CLUchr8

27468826

-
intron-5UTRENST00000405140ENST00000405140CLUchr8

27457324

-CLUchr8

27468826

-
intron-5UTRENST00000405140ENST00000523500CLUchr8

27457324

-CLUchr8

27468826

-
intron-intronENST00000523500ENST00000316403CLUchr8

27457324

-CLUchr8

27468826

-
intron-intronENST00000523500ENST00000546343CLUchr8

27457324

-CLUchr8

27468826

-
intron-intronENST00000523500ENST00000560366CLUchr8

27457324

-CLUchr8

27468826

-
intron-5UTRENST00000523500ENST00000405140CLUchr8

27457324

-CLUchr8

27468826

-
intron-5UTRENST00000523500ENST00000523500CLUchr8

27457324

-CLUchr8

27468826

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for CLU-CLU


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CLU-CLU


check button Go to

FGviewer for the breakpoints of chr8:27466459-chr8:27462611

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLU

P10909

CLU

Q15846

FUNCTION: [Isoform 1]: Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed:11123922, PubMed:19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed:11123922, PubMed:12176985, PubMed:17260971, PubMed:19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed:12047389, PubMed:17412999, PubMed:17407782). Does not require ATP (PubMed:11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed:11123922). Does not refold proteins by itself (PubMed:11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed:21505792). Protects cells against apoptosis and against cytolysis by complement (PubMed:2780565). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed:20068069). Modulates NF-kappa-B transcriptional activity (PubMed:12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed:16113678, PubMed:17689225). Plays a role in the regulation of cell proliferation (PubMed:19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed:22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity). {ECO:0000250|UniProtKB:P05371, ECO:0000250|UniProtKB:Q06890, ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:12047389, ECO:0000269|PubMed:12176985, ECO:0000269|PubMed:12882985, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17407782, ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:17689225, ECO:0000269|PubMed:19137541, ECO:0000269|PubMed:19535339, ECO:0000269|PubMed:19996109, ECO:0000269|PubMed:20068069, ECO:0000269|PubMed:21505792, ECO:0000269|PubMed:22689054, ECO:0000269|PubMed:24073260, ECO:0000269|PubMed:2780565}.; FUNCTION: [Isoform 6]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. {ECO:0000269|PubMed:24073260}.; FUNCTION: [Isoform 4]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed:24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed:21567405). {ECO:0000269|PubMed:21567405, ECO:0000269|PubMed:24073260}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLUchr8:27466459chr8:27462611ENST00000316403-3978_8182.0450.0MotifNuclear localization signal
HgeneCLUchr8:27466459chr8:27462611ENST00000405140-3978_8182.0450.0MotifNuclear localization signal
HgeneCLUchr8:27466459chr8:27462611ENST00000523500-2878_8182.0450.0MotifNuclear localization signal
HgeneCLUchr8:27466459chr8:27462611ENST00000546343-3978_8193.0461.0MotifNuclear localization signal
HgeneCLUchr8:27466459chr8:27462611ENST00000560366-3978_81134.0502.0MotifNuclear localization signal
TgeneCLUchr8:27466459chr8:27462611ENST0000031640309443_4470450.0MotifNuclear localization signal
TgeneCLUchr8:27466459chr8:27462611ENST000003164030978_810450.0MotifNuclear localization signal
TgeneCLUchr8:27466459chr8:27462611ENST0000040514009443_4470450.0MotifNuclear localization signal
TgeneCLUchr8:27466459chr8:27462611ENST000004051400978_810450.0MotifNuclear localization signal
TgeneCLUchr8:27466459chr8:27462611ENST0000052350008443_4470450.0MotifNuclear localization signal
TgeneCLUchr8:27466459chr8:27462611ENST000005235000878_810450.0MotifNuclear localization signal
TgeneCLUchr8:27466459chr8:27462611ENST0000054634309443_4470461.0MotifNuclear localization signal
TgeneCLUchr8:27466459chr8:27462611ENST000005463430978_810461.0MotifNuclear localization signal
TgeneCLUchr8:27466459chr8:27462611ENST0000056036609443_4470502.0MotifNuclear localization signal
TgeneCLUchr8:27466459chr8:27462611ENST000005603660978_810502.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLUchr8:27466459chr8:27462611ENST00000316403-39443_44782.0450.0MotifNuclear localization signal
HgeneCLUchr8:27466459chr8:27462611ENST00000405140-39443_44782.0450.0MotifNuclear localization signal
HgeneCLUchr8:27466459chr8:27462611ENST00000523500-28443_44782.0450.0MotifNuclear localization signal
HgeneCLUchr8:27466459chr8:27462611ENST00000546343-39443_44793.0461.0MotifNuclear localization signal
HgeneCLUchr8:27466459chr8:27462611ENST00000560366-39443_447134.0502.0MotifNuclear localization signal


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Fusion Gene Sequence for CLU-CLU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CLU-CLU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CLU-CLU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCLUP10909DB14548Zinc sulfate, unspecified formInducerSmall moleculeApproved|Experimental
HgeneCLUP10909DB14548Zinc sulfate, unspecified formInducerSmall moleculeApproved|Experimental
HgeneCLUP10909DB14548Zinc sulfate, unspecified formInducerSmall moleculeApproved|Experimental
HgeneCLUP10909DB14548Zinc sulfate, unspecified formInducerSmall moleculeApproved|Experimental
HgeneCLUP10909DB14548Zinc sulfate, unspecified formInducerSmall moleculeApproved|Experimental
HgeneCLUP10909DB01593ZincSmall moleculeApproved|Investigational
HgeneCLUP10909DB01593ZincSmall moleculeApproved|Investigational
HgeneCLUP10909DB01593ZincSmall moleculeApproved|Investigational
HgeneCLUP10909DB01593ZincSmall moleculeApproved|Investigational
HgeneCLUP10909DB01593ZincSmall moleculeApproved|Investigational
HgeneCLUP10909DB09130CopperSmall moleculeApproved|Investigational
HgeneCLUP10909DB09130CopperSmall moleculeApproved|Investigational
HgeneCLUP10909DB09130CopperSmall moleculeApproved|Investigational
HgeneCLUP10909DB09130CopperSmall moleculeApproved|Investigational
HgeneCLUP10909DB09130CopperSmall moleculeApproved|Investigational
HgeneCLUP10909DB14487Zinc acetateSmall moleculeApproved|Investigational
HgeneCLUP10909DB14487Zinc acetateSmall moleculeApproved|Investigational
HgeneCLUP10909DB14487Zinc acetateSmall moleculeApproved|Investigational
HgeneCLUP10909DB14487Zinc acetateSmall moleculeApproved|Investigational
HgeneCLUP10909DB14487Zinc acetateSmall moleculeApproved|Investigational
HgeneCLUP10909DB14533Zinc chlorideInducerSmall moleculeApproved|Investigational
HgeneCLUP10909DB14533Zinc chlorideInducerSmall moleculeApproved|Investigational
HgeneCLUP10909DB14533Zinc chlorideInducerSmall moleculeApproved|Investigational
HgeneCLUP10909DB14533Zinc chlorideInducerSmall moleculeApproved|Investigational
HgeneCLUP10909DB14533Zinc chlorideInducerSmall moleculeApproved|Investigational

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Related Diseases for CLU-CLU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLUC0022660Kidney Failure, Acute6CTD_human
HgeneCLUC1565662Acute Kidney Insufficiency6CTD_human
HgeneCLUC2609414Acute kidney injury6CTD_human
HgeneCLUC0002395Alzheimer's Disease3CTD_human
HgeneCLUC0011265Presenile dementia3CTD_human
HgeneCLUC0022658Kidney Diseases3CTD_human
HgeneCLUC0276496Familial Alzheimer Disease (FAD)3CTD_human
HgeneCLUC0494463Alzheimer Disease, Late Onset3CTD_human
HgeneCLUC0546126Acute Confusional Senile Dementia3CTD_human
HgeneCLUC0750900Alzheimer's Disease, Focal Onset3CTD_human
HgeneCLUC0750901Alzheimer Disease, Early Onset3CTD_human
HgeneCLUC0013221Drug toxicity2CTD_human
HgeneCLUC0029408Degenerative polyarthritis2CTD_human
HgeneCLUC0041755Adverse reaction to drug2CTD_human
HgeneCLUC0086743Osteoarthrosis Deformans2CTD_human
HgeneCLUC0019193Hepatitis, Toxic1CTD_human
HgeneCLUC0022333Jacksonian Seizure1CTD_human
HgeneCLUC0024141Lupus Erythematosus, Systemic1CTD_human
HgeneCLUC0025202melanoma1CTD_human
HgeneCLUC0027686Pathologic Neovascularization1CTD_human
HgeneCLUC0033578Prostatic Neoplasms1CTD_human
HgeneCLUC0036341Schizophrenia1PSYGENET
HgeneCLUC0036572Seizures1CTD_human
HgeneCLUC0087031Juvenile-Onset Still Disease1CTD_human
HgeneCLUC0149958Complex partial seizures1CTD_human
HgeneCLUC0234533Generalized seizures1CTD_human
HgeneCLUC0234535Clonic Seizures1CTD_human
HgeneCLUC0234985Mental deterioration1CTD_human
HgeneCLUC0242380Libman-Sacks Disease1CTD_human
HgeneCLUC0270824Visual seizure1CTD_human
HgeneCLUC0270844Tonic Seizures1CTD_human
HgeneCLUC0270846Epileptic drop attack1CTD_human
HgeneCLUC0333641Atrophic1CTD_human
HgeneCLUC0338656Impaired cognition1CTD_human
HgeneCLUC0376358Malignant neoplasm of prostate1CTD_human
HgeneCLUC0422850Seizures, Somatosensory1CTD_human
HgeneCLUC0422852Seizures, Auditory1CTD_human
HgeneCLUC0422853Olfactory seizure1CTD_human
HgeneCLUC0422854Gustatory seizure1CTD_human
HgeneCLUC0422855Vertiginous seizure1CTD_human
HgeneCLUC0494475Tonic - clonic seizures1CTD_human
HgeneCLUC0751056Non-epileptic convulsion1CTD_human
HgeneCLUC0751110Single Seizure1CTD_human
HgeneCLUC0751123Atonic Absence Seizures1CTD_human
HgeneCLUC0751494Convulsive Seizures1CTD_human
HgeneCLUC0751495Seizures, Focal1CTD_human
HgeneCLUC0751496Seizures, Sensory1CTD_human
HgeneCLUC0860207Drug-Induced Liver Disease1CTD_human
HgeneCLUC1262760Hepatitis, Drug-Induced1CTD_human
HgeneCLUC1270972Mild cognitive disorder1CTD_human
HgeneCLUC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneCLUC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
HgeneCLUC3495559Juvenile arthritis1CTD_human
HgeneCLUC3495874Nonepileptic Seizures1CTD_human
HgeneCLUC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneCLUC3714758Juvenile psoriatic arthritis1CTD_human
HgeneCLUC4048158Convulsions1CTD_human
HgeneCLUC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneCLUC4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneCLUC4316903Absence Seizures1CTD_human
HgeneCLUC4317109Epileptic Seizures1CTD_human
HgeneCLUC4317123Myoclonic Seizures1CTD_human
HgeneCLUC4505436Generalized Absence Seizures1CTD_human
HgeneCLUC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human
HgeneCLUC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneCLUC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneCLUC0022660Kidney Failure, Acute6CTD_human
TgeneCLUC1565662Acute Kidney Insufficiency6CTD_human
TgeneCLUC2609414Acute kidney injury6CTD_human
TgeneCLUC0002395Alzheimer's Disease3CTD_human
TgeneCLUC0011265Presenile dementia3CTD_human
TgeneCLUC0022658Kidney Diseases3CTD_human
TgeneCLUC0276496Familial Alzheimer Disease (FAD)3CTD_human
TgeneCLUC0494463Alzheimer Disease, Late Onset3CTD_human
TgeneCLUC0546126Acute Confusional Senile Dementia3CTD_human
TgeneCLUC0750900Alzheimer's Disease, Focal Onset3CTD_human
TgeneCLUC0750901Alzheimer Disease, Early Onset3CTD_human
TgeneCLUC0013221Drug toxicity2CTD_human
TgeneCLUC0029408Degenerative polyarthritis2CTD_human
TgeneCLUC0041755Adverse reaction to drug2CTD_human
TgeneCLUC0086743Osteoarthrosis Deformans2CTD_human
TgeneCLUC0019193Hepatitis, Toxic1CTD_human
TgeneCLUC0022333Jacksonian Seizure1CTD_human
TgeneCLUC0024141Lupus Erythematosus, Systemic1CTD_human
TgeneCLUC0025202melanoma1CTD_human
TgeneCLUC0027686Pathologic Neovascularization1CTD_human
TgeneCLUC0033578Prostatic Neoplasms1CTD_human
TgeneCLUC0036341Schizophrenia1PSYGENET
TgeneCLUC0036572Seizures1CTD_human
TgeneCLUC0087031Juvenile-Onset Still Disease1CTD_human
TgeneCLUC0149958Complex partial seizures1CTD_human
TgeneCLUC0234533Generalized seizures1CTD_human
TgeneCLUC0234535Clonic Seizures1CTD_human
TgeneCLUC0234985Mental deterioration1CTD_human
TgeneCLUC0242380Libman-Sacks Disease1CTD_human
TgeneCLUC0270824Visual seizure1CTD_human
TgeneCLUC0270844Tonic Seizures1CTD_human
TgeneCLUC0270846Epileptic drop attack1CTD_human
TgeneCLUC0333641Atrophic1CTD_human
TgeneCLUC0338656Impaired cognition1CTD_human
TgeneCLUC0376358Malignant neoplasm of prostate1CTD_human
TgeneCLUC0422850Seizures, Somatosensory1CTD_human
TgeneCLUC0422852Seizures, Auditory1CTD_human
TgeneCLUC0422853Olfactory seizure1CTD_human
TgeneCLUC0422854Gustatory seizure1CTD_human
TgeneCLUC0422855Vertiginous seizure1CTD_human
TgeneCLUC0494475Tonic - clonic seizures1CTD_human
TgeneCLUC0751056Non-epileptic convulsion1CTD_human
TgeneCLUC0751110Single Seizure1CTD_human
TgeneCLUC0751123Atonic Absence Seizures1CTD_human
TgeneCLUC0751494Convulsive Seizures1CTD_human
TgeneCLUC0751495Seizures, Focal1CTD_human
TgeneCLUC0751496Seizures, Sensory1CTD_human
TgeneCLUC0860207Drug-Induced Liver Disease1CTD_human
TgeneCLUC1262760Hepatitis, Drug-Induced1CTD_human
TgeneCLUC1270972Mild cognitive disorder1CTD_human
TgeneCLUC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneCLUC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneCLUC3495559Juvenile arthritis1CTD_human
TgeneCLUC3495874Nonepileptic Seizures1CTD_human
TgeneCLUC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneCLUC3714758Juvenile psoriatic arthritis1CTD_human
TgeneCLUC4048158Convulsions1CTD_human
TgeneCLUC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneCLUC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneCLUC4316903Absence Seizures1CTD_human
TgeneCLUC4317109Epileptic Seizures1CTD_human
TgeneCLUC4317123Myoclonic Seizures1CTD_human
TgeneCLUC4505436Generalized Absence Seizures1CTD_human
TgeneCLUC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human
TgeneCLUC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneCLUC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human