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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CMIP-UBE2G1 (FusionGDB2 ID:17558)

Fusion Gene Summary for CMIP-UBE2G1

check button Fusion gene summary
Fusion gene informationFusion gene name: CMIP-UBE2G1
Fusion gene ID: 17558
HgeneTgene
Gene symbol

CMIP

UBE2G1

Gene ID

80790

7326

Gene namec-Maf inducing proteinubiquitin conjugating enzyme E2 G1
SynonymsTCMIPE217K|UBC7|UBE2G
Cytomap

16q23.2-q23.3

17p13.2

Type of geneprotein-codingprotein-coding
DescriptionC-Maf-inducing proteintc-Mipubiquitin-conjugating enzyme E2 G1E2 ubiquitin-conjugating enzyme G1ubiquitin carrier protein G1ubiquitin conjugating enzyme E2G 1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)ub
Modification date2020031320200313
UniProtAcc

Q8IY22

.
Ensembl transtripts involved in fusion geneENST00000537098, ENST00000539778, 
ENST00000566513, ENST00000398040, 
ENST00000396981, ENST00000572484, 
Fusion gene scores* DoF score23 X 18 X 9=372614 X 8 X 8=896
# samples 2815
** MAII scorelog2(28/3726*10)=-3.73412894199667
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/896*10)=-2.57853623156172
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CMIP [Title/Abstract] AND UBE2G1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCMIP(81479146)-UBE2G1(4210418), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBE2G1

GO:0070534

protein K63-linked ubiquitination

20061386

TgeneUBE2G1

GO:0070936

protein K48-linked ubiquitination

14593114|20061386


check buttonFusion gene breakpoints across CMIP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across UBE2G1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-QL-A97D-01ACMIPchr16

81479146

+UBE2G1chr17

4210418

-
ChimerDB4COADTCGA-QL-A97DCMIPchr16

81479146

+UBE2G1chr17

4210418

-
ChimerDB4COADTCGA-QL-A97D-01ACMIPchr16

81479146

+UBE2G1chr17

4210418

-
ChimerDB4COADTCGA-QL-A97D-01ACMIPchr16

81479146

-UBE2G1chr17

4210418

-


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Fusion Gene ORF analysis for CMIP-UBE2G1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000537098ENST00000396981CMIPchr16

81479146

+UBE2G1chr17

4210418

-
5CDS-5UTRENST00000537098ENST00000572484CMIPchr16

81479146

+UBE2G1chr17

4210418

-
intron-3CDSENST00000539778ENST00000396981CMIPchr16

81479146

+UBE2G1chr17

4210418

-
intron-5UTRENST00000539778ENST00000572484CMIPchr16

81479146

+UBE2G1chr17

4210418

-
intron-3CDSENST00000566513ENST00000396981CMIPchr16

81479146

+UBE2G1chr17

4210418

-
intron-5UTRENST00000566513ENST00000572484CMIPchr16

81479146

+UBE2G1chr17

4210418

-
intron-3CDSENST00000398040ENST00000396981CMIPchr16

81479146

+UBE2G1chr17

4210418

-
intron-5UTRENST00000398040ENST00000572484CMIPchr16

81479146

+UBE2G1chr17

4210418

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000537098CMIPchr1681479146+ENST00000396981UBE2G1chr174210418-4134372188838216

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000537098ENST00000396981CMIPchr1681479146+UBE2G1chr174210418-0.309580060.69042

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Fusion Genomic Features for CMIP-UBE2G1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CMIP-UBE2G1


check button Go to

FGviewer for the breakpoints of chr16:81479146-chr17:4210418

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CMIP

Q8IY22

.
FUNCTION: Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. {ECO:0000269|PubMed:12939343, ECO:0000269|PubMed:15128042}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCMIPchr16:81479146chr17:4210418ENST00000398040+11954_1630621.0DomainNote=PH
HgeneCMIPchr16:81479146chr17:4210418ENST00000537098+12154_163100.0774.0DomainNote=PH
HgeneCMIPchr16:81479146chr17:4210418ENST00000539778+12154_1630680.0DomainNote=PH
HgeneCMIPchr16:81479146chr17:4210418ENST00000398040+119663_6860621.0RepeatNote=LRR 1
HgeneCMIPchr16:81479146chr17:4210418ENST00000398040+119687_7070621.0RepeatNote=LRR 2
HgeneCMIPchr16:81479146chr17:4210418ENST00000398040+119712_7320621.0RepeatNote=LRR 3
HgeneCMIPchr16:81479146chr17:4210418ENST00000398040+119736_7560621.0RepeatNote=LRR 4
HgeneCMIPchr16:81479146chr17:4210418ENST00000537098+121663_686100.0774.0RepeatNote=LRR 1
HgeneCMIPchr16:81479146chr17:4210418ENST00000537098+121687_707100.0774.0RepeatNote=LRR 2
HgeneCMIPchr16:81479146chr17:4210418ENST00000537098+121712_732100.0774.0RepeatNote=LRR 3
HgeneCMIPchr16:81479146chr17:4210418ENST00000537098+121736_756100.0774.0RepeatNote=LRR 4
HgeneCMIPchr16:81479146chr17:4210418ENST00000539778+121663_6860680.0RepeatNote=LRR 1
HgeneCMIPchr16:81479146chr17:4210418ENST00000539778+121687_7070680.0RepeatNote=LRR 2
HgeneCMIPchr16:81479146chr17:4210418ENST00000539778+121712_7320680.0RepeatNote=LRR 3
HgeneCMIPchr16:81479146chr17:4210418ENST00000539778+121736_7560680.0RepeatNote=LRR 4
TgeneUBE2G1chr16:81479146chr17:4210418ENST00000396981065_16615.3333333333333341193.3333333333333DomainUBC core


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Fusion Gene Sequence for CMIP-UBE2G1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000537098_ENST00000396981_TCGA-QL-A97D-01A_CMIP_chr16_81479146_+_UBE2G1_chr17_4210418_length(transcript)=4134nt_BP=372nt
GGGGGCCCCGCCGCCCCAGCAGCCCAGGACAGCCCCCTCTCCCCGCCCCCAGCCCCCTCCCCCGGCGCGGCCATGGATGTGACCAGCAGC
TCGGGCGGCGGCGGCGACCCCCGGCAGATCGAGGAGACCAAGCCGCTGCTGGGGGGCGACGTGTCGGCCCCCGAAGGCACGAAGATGGGC
GCCGTGCCCTGCCGCCGGGCTCTTCTGCTTTGCAACGGGATGAGGTACAAACTGCTGCAGGAGGGCGACATTCAGGTCTGTGTCATCCGG
CACCCGCGGACCTTTCTCAGCAAGATCCTCACCTCGAAATTCCTGAGGCGCTGGGAGCCGCACCACCTAACGCTGGCCGACAACAGCCTG
GCGTCCGCCACGAACTCAACAAAAATCCAGTGGAAGGCTTTTCTGCAGGTTTAATAGATGACAATGATCTCTACCGATGGGAAGTCCTTA
TTATTGGCCCTCCAGATACACTTTATGAAGGTGGTGTTTTTAAGGCTCATCTTACTTTCCCAAAAGATTATCCCCTCCGACCTCCTAAAA
TGAAATTCATTACAGAAATCTGGCACCCAAATGTTGATAAAAATGGTGATGTGTGCATTTCTATTCTTCATGAGCCTGGGGAAGATAAGT
ATGGTTATGAAAAGCCAGAGGAACGCTGGCTCCCTATCCACACTGTGGAAACCATCATGATTAGTGTCATTTCTATGCTGGCAGACCCTA
ATGGAGACTCACCTGCTAATGTTGATGCTGCGAAAGAATGGAGGGAAGATAGAAATGGAGAATTTAAAAGAAAAGTTGCCCGCTGTGTAA
GAAAAAGCCAAGAGACTGCTTTTGAGTGACATTTATTTAGCAGCTAGTAACTTCACTTATTTCAGGGTCTCCAATTGAGAAACATGGCAC
TGTTTTTCCTGCACTCTACCCACCTATTGCTGGACTTCTGTTGTACAAGTTGGCAAACACTGGCTGGAACTGGGCTGCAATAAAACATGC
CAGTTATCAATGCTGACAAGAGCCTAACAAGTGCCAACTTACAGATGATTACGCATTTTGAATTCTAATGAACTGTTTTAACCTTCAGGA
AGAATTGTAAAGACCTGTACATAGCACAACATGATCCGGATAATATATATACTGTTCATGTACATCCACAAATACACCTTGTACCAAATA
ATGCTTTCTTGTAGTAGAATAAGAATCGTGTAAATTCTAAGAGATTTTAGCAGGTTTTCTTTCCTATTCATTGTTTCTTATCAGTTTAAA
AGGATTCCTTTAAGCATGTCAGATGAAAAGCAATTAGGATTAAAAGTTTCCATTTAATTTCCCTTAAACCCTTGAGGCTTCATTAAACTC
TTTTCACTTACTAAACTTTTGTATCTTCTTTGTTTTGACACACTCCCCTTTGCTTTTATCTCTTACCTGCCAGAATGTTCTCAAATGATT
TAGTTCAAATACTGAAATACTTAATGAGCAATTACTTGATTTTTAATGATGACTTCGAAGGAGTCATCACTAGGTGCTTTGTCCTTTTTG
TATTCTAGTTGCACCCACCTCTTGGATTGGATATAGCAATAACATTTATTGGCCGTTGTGAGCTCTTGATCCCAGTCATTACCCCTGAGA
ACTAAAAATAGATGGTTCTTAATTCAACTTACTGAAAATTTCCCCAAACAATAGCAAATCTGACTTTTCCCTCTTCAGTTGCCTGGTATT
AAGGTTGGATAAATGAAGCATGCACAGCTACAGGCTTTCTACTTAACTTCTGGGTTTGCTATTACAAATCCTATTTACTCTCATACCCTT
CTCCTTAGTCCTTCATATTTCTCTGCCTCTATTCTTCTATACTGCAGATTTTTCTCACCTATTGTACAAAGAAATTGCGATGTATATTTT
CATGTAATTTGATTTTGGAATTCTGTCACCTTATGTAGTGAGTTCTTCCAAAATATAATTTTTTTTCAATAATTGTCAAGTTGTTGGCTT
TTATTGTATTGAATGAAGGCTATAATACTGAGTGCCAGAGAAGTGGTTTAGGAAAATCTCAGGTTGATTCCTTATGCAAATGAACTTTTA
ATACTTGAAAATCACATGGCCATGGCAGTATATGTATTTGGTTCTATCTAGATTCTTCTGTGAATCTAAAAGCATTACAGGGGTAAATGC
TTTGCTATTTGACGTATAGATCCCGTCACTAACAATAGTACACTTGGATGTGATTAATGTTTGAGCTTCAATATATTTCATATCATACAG
TTTTCTAAAACAACTTCAGCAAATGGTAAAATGAACATGTGCAGTGTTAAAGGCAGGCCTTAGGCTCCTTCATGTTTGTTGTGAGGTTGT
GTGTGGGAAGTAGTCTTTGGCTTATAAGGGATAGAACTTGAGACAGTAGCAGATGGGACATGGTGTTTGATTGTGAGAATCAGTGAGAAT
TCGTGCATCTCTGCTCTGTGGGGTTTGGAGAAATGCTTTGGCAGAAGAGTGAAAGAACTCCTGCCAAGAGCCCAGACCTCTACAAACGTT
GTATGTCCTTTTTTAAGCAGAAATAAAATGGTTGAGGATGTAGTCACAGTAGAGAGTGATTTTTTTCTAAGTCCCTGTCCTCTACTCTGA
AGCGTTATAAAAACCTGTAAACATTATACAAACCCACAAACCTTATAGAAACTCGTAAGTGTGTTGTGACTGGAAATTGATTCATTAGAA
CCCAGTTTTCTTTAAGAACTTTGTGACTTGGTTTTTTTTTTCCTTTTCCAAAGACTGTAAAAATAGTTGCCCCAAAATGTCAGCACTGCA
CACCCTCCAGGGACTTGGAATACAATCCTTTTTACTTTTTTTTTTTTTTTTTTAAGAAACTGGGTCTCTCTGTCACCCAGGCTGGAGTGC
AGTGGCAACGATCATAGCTAACTGCAGCTTTGACCTCCTGGGCTCAAGTGATCCTCCTGCCTCAGCCTCCTGAGTAGCTAGGACTACAGG
TGTATGCCACCATGCCTGGCTAATACAAAAAAATTCTTTTAAGAGATGGGATCCCTCCCTTTTAAAATCAGAACTTGTTCACATGGTGGT
TGCTTGTGGCAAAACGGAGTTCAAATTTTGCTCTCCTATTGCTATAATTCTGCTAGCAATCTGTTGAGGTGAAACTTGGGATCTGACTCT
TCAGCAAGCAGCAAATGACCTAGTAACTCAGGGACAACTATTTTTGAACTTTAAGTGCCACTTTAATGCAGTTAGTTTGATAAAACCATG
TGGGTTTTTTTTTTAGGGCTAGCTCTACGGGAGTGGAAGTGAGAGCCAGGCATGAGTGCGTCTCCACATGCTTTTCCACCTGCCCTGAGT
GTGTTACATACTGAAACAGGCCTACATAGATGTTACAACTTCCCTTCCTCTGTCGGAGATGTCATCTGTGCCTTTCTCAGTGTTCATCTG
ATAATGTAAATTTAAATGCCTCTACATTTGATACGAAACCCACATTCAGGTGACACTGAACGAGGTGGCTTTTGTCCCACCAGTGCCTCA
TCAGTGTGAGGCGATTCCTCTCTGCTTTAGGAAAATGATTTTTCCCCCTAAACTTGTGCCAACCATCAACAACATCTCCATAGATCTTAT
GGATTGTAGAACTGTTGGCTGTTTCCTAAATTTATTCCAAGTTCTCGTAGAGGCATATAGATTTCAGTCTGTGCTTGTATGGGATAGATG
ATCTGAGTGGCTTTCTGGCCTCTTTTTTGAGTTTAAAATCCATATGAGGTTGACGTGTCATACTAAGGTAACATGTTTGTGAGGTTATTC
CACTAGTACTGTGATCACGTGGGTGTCAGTATCTTTAACGGCCTTCATTCTTGGTTGTGAGATTTTATTTGATATGCCCACTCACCCTCG
ACGAATCTGCCCGCTTTGGGCTGTGGTGCCTGTGTATCTTTGCCCGTCTGGTCTCCAGTTGGTGGAATTACCTTTTTTGTACTGCCACTT
CTCAGCATCTTTGAAATTTGACATAATGTTGCTTCATTTCAGTTTTTTTAGTTCTGTAATTTGTTGATTGTATTTAACTATGTGAGTTCT

>In-frame_ENST00000537098_ENST00000396981_TCGA-QL-A97D-01A_CMIP_chr16_81479146_+_UBE2G1_chr17_4210418_length(amino acids)=216AA_start in transcript=188_stop in transcript=838
MPPGSSALQRDEVQTAAGGRHSGLCHPAPADLSQQDPHLEIPEALGAAPPNAGRQQPGVRHELNKNPVEGFSAGLIDDNDLYRWEVLIIG
PPDTLYEGGVFKAHLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTVETIMISVISMLADPNGD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CMIP-UBE2G1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CMIP-UBE2G1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CMIP-UBE2G1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCMIPC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human