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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CNN2-SSU72 (FusionGDB2 ID:17695)

Fusion Gene Summary for CNN2-SSU72

check button Fusion gene summary
Fusion gene informationFusion gene name: CNN2-SSU72
Fusion gene ID: 17695
HgeneTgene
Gene symbol

CNN2

SSU72

Gene ID

1265

29101

Gene namecalponin 2SSU72 homolog, RNA polymerase II CTD phosphatase
Synonyms-HSPC182|PNAS-120
Cytomap

19p13.3

1p36.33

Type of geneprotein-codingprotein-coding
Descriptioncalponin-2calponin H2, smooth muscleneutral calponinRNA polymerase II subunit A C-terminal domain phosphatase SSU72CTD phosphatase SSU72
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263097, ENST00000606983, 
ENST00000348419, ENST00000565096, 
ENST00000562958, 		ENST00000291386, 
ENST00000359060, 
Fusion gene scores* DoF score9 X 8 X 6=43214 X 7 X 10=980
# samples 917
** MAII scorelog2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/980*10)=-2.52724700286487
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNN2 [Title/Abstract] AND SSU72 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCNN2(1032695)-SSU72(1500298), # samples:1
Anticipated loss of major functional domain due to fusion event.CNN2-SSU72 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CNN2-SSU72 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNN2

GO:0032970

regulation of actin filament-based process

16236705

HgeneCNN2

GO:0071260

cellular response to mechanical stimulus

16236705

TgeneSSU72

GO:0070940

dephosphorylation of RNA polymerase II C-terminal domain

20861839


check buttonFusion gene breakpoints across CNN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SSU72 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADB278470CNN2chr19

1032695

+SSU72chr1

1500298

-


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Fusion Gene ORF analysis for CNN2-SSU72

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000263097ENST00000291386CNN2chr19

1032695

+SSU72chr1

1500298

-
In-frameENST00000263097ENST00000359060CNN2chr19

1032695

+SSU72chr1

1500298

-
3UTR-3CDSENST00000606983ENST00000291386CNN2chr19

1032695

+SSU72chr1

1500298

-
3UTR-3CDSENST00000606983ENST00000359060CNN2chr19

1032695

+SSU72chr1

1500298

-
Frame-shiftENST00000348419ENST00000291386CNN2chr19

1032695

+SSU72chr1

1500298

-
In-frameENST00000348419ENST00000359060CNN2chr19

1032695

+SSU72chr1

1500298

-
intron-3CDSENST00000565096ENST00000291386CNN2chr19

1032695

+SSU72chr1

1500298

-
intron-3CDSENST00000565096ENST00000359060CNN2chr19

1032695

+SSU72chr1

1500298

-
Frame-shiftENST00000562958ENST00000291386CNN2chr19

1032695

+SSU72chr1

1500298

-
In-frameENST00000562958ENST00000359060CNN2chr19

1032695

+SSU72chr1

1500298

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263097CNN2chr191032695+ENST00000359060SSU72chr11500298-3325753234839201
ENST00000348419CNN2chr191032695+ENST00000359060SSU72chr11500298-301344151527158
ENST00000562958CNN2chr191032695+ENST00000359060SSU72chr11500298-299542333509158

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263097ENST00000359060CNN2chr191032695+SSU72chr11500298-0.0153485490.98465145
ENST00000348419ENST00000359060CNN2chr191032695+SSU72chr11500298-0.0154091060.9845909
ENST00000562958ENST00000359060CNN2chr191032695+SSU72chr11500298-0.0116020150.988398

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Fusion Genomic Features for CNN2-SSU72


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CNN2-SSU72


check button Go to

FGviewer for the breakpoints of chr19:1032695-chr1:1500298

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNN2chr19:1032695chr1:1500298ENST00000263097+4728_132130.0310.0DomainCalponin-homology (CH)
HgeneCNN2chr19:1032695chr1:1500298ENST00000348419+4628_132130.0271.0DomainCalponin-homology (CH)
TgeneSSU72chr19:1032695chr1:1500298ENST0000029138605160_18626.666666666666668195.0Coiled coilOntology_term=ECO:0000255
TgeneSSU72chr19:1032695chr1:1500298ENST0000035906002160_18626.666666666666668154.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNN2chr19:1032695chr1:1500298ENST00000263097+47166_191130.0310.0RepeatNote=Calponin-like 1
HgeneCNN2chr19:1032695chr1:1500298ENST00000263097+47206_231130.0310.0RepeatNote=Calponin-like 2
HgeneCNN2chr19:1032695chr1:1500298ENST00000263097+47245_269130.0310.0RepeatNote=Calponin-like 3
HgeneCNN2chr19:1032695chr1:1500298ENST00000348419+46166_191130.0271.0RepeatNote=Calponin-like 1
HgeneCNN2chr19:1032695chr1:1500298ENST00000348419+46206_231130.0271.0RepeatNote=Calponin-like 2
HgeneCNN2chr19:1032695chr1:1500298ENST00000348419+46245_269130.0271.0RepeatNote=Calponin-like 3


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Fusion Gene Sequence for CNN2-SSU72


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000263097_ENST00000359060_DB278470_CNN2_chr19_1032695_+_SSU72_chr1_1500298_length(transcript)=3325nt_BP=753nt
GAAAGAGTGAGAGCCGCCCACGAGCTCTGAGCAGAGAGCCCGCAGGAGTGCCACGTCCCGGCGGCCTCGGCCCCTCCCTGCCTCAGTTTC
CCGTGGCATCAAAGGGGGCGAGGGGCCCCTCCAGGCCTCTGGTGACGGGGGTGCTGTGCCCAGGCGGGGGTCCGGGGGCGACCGAGGGGG
CTCAGGAAGTCCGCGGCCGCAGGAATTCGGCGCCTCCAGGCCTTATAAGGACATTTGCGCTCCGGGCCAATCAGCGGCGGGGGCGTGGCG
CGCGGAGCCCGGCGCGTCCCAACCCCGCGCCAGCCCGGCGGTCCCGTCCCGTCCCGTCCTGTGCGGCCCCGTCCCGCCGCCCGCCCGCCA
GCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGGCTGTCGGCCGAGGTCAAGAACCGGCTCCTGTCCAAATATGACCCCCAG
AAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGCCTCTCCATCGGCCCCGACTTCCAGAAGGGCCTGAAGGATGGAACTATC
TTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCCAAGATCAACCGCTCCATGCAGAACTGGCACCAGCTAGAAAACCTGTCC
AACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTGGACCTGTTCGAGGCCAACGACCTGTTTGAGAGTGGGAACATGACGCAG
GTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCAAACGGGGATTCAGCGTCCGATCCTTTGGAACAGGGACTCACGTGAAGCTTCCAGG
ACCAGCTCCCGACAAGCCCAATGTTTATGATTTCAAAACCACATATGACCAGATGTACAATGATCTTCTTAGGAAAGACAAAGAACTGTA
TCCCAGCGGGTTGCCCTTTAAAAACCCCCCGTGTGGTCCTCCCTGGAAGGTGTTACGTGTGGCTCGGGCACAGGAGGCGTGTCACCCTGT
GCAGTGCACACACTGGCTCCTCTGTCTTTGCGAGAGCTTGGTTTCTATTCCTGGTGCACGTCGGATCGTCCACGGGTTAGTTCCAGTGCC
ACCCATGGCAGTAGGCGTGGTGAGGCGCACAGACACGGTGTGGGGTTCACCCTGACGTGGTTCAGCAGAGGGTCGTGACATAGCGTAGAC
CAGGGATGCTTAGGTGAGGAGGTGGAACCCACAAAATCCCATTGCTTTTCACACTGCAGGGCTGCCCCGTTATTTCCTTTGCAGGTTGGT
GTGCGTGCGTGTGTGCGTGCGTGCCTGATACACATGGAGCCGGGCTGCTTCACACATCTGGTGAGGTCGTTAGAAGGTCAGATAAAGAAG
AGGGCGGAGCTTGCTAACCAAGCTGTTAGAAGAAATAATGGGAGAGAACATTCCTTCATTTCAGGAGGACACAGAGCAGGCTAGGTCTGC
CGCGAAGACTCCTATAGAGAGAAGAGTATTCTTAAACTAGATTCTGATGGACGCAACACCAGTTGCATAATGGTTATGACAATCAGTGCC
CGGGTTTTTGACCAGGCATTTCATGGTCACCCCCACGCTAATGGAAAGTTTCTGGATCTTATTTTGTTATAGTGAGTGATTTGTAGTTTT
CAGAACGGAGGCCAGGCCAAACGTATTCCAAATGAAAAGAGAATAGGTGTCAAATGCTAAACCTTTTATCTTCGTGTTGGCACTGTTGCC
ATCCCCGCCCTCTCCCGACATCCCCGCCCTTGACCAGCATCTCTGGCCTTGCCCAGCATTGTCTATGTATTGGCACTCTTGCCATCCCCG
CCCTTTCCCAGCAGAGTCTCACTGTGTCACCCCGGCTGGAGTGCAGTGGCGAGATCTTGGCTCACTGCAGACTCACTGCAACATCCACCT
CCCGGGTTCCAGTGATTCTCCTGCTTCAGCCTCCTGGGTAGCTGGGATTACAGGCACGCGCCACCACACCTGGCTAATTTTTGTATTTTT
AGTAGTCACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTAAACTCCTGACTTCAGGTGATCCACCCTCCTCGTCCTCCCAAAGTGCTGG
GATTACAGGCGTGAGCCACCATGCTCAGCCCTACTCTTGTATTTTTTTTTTTTTTTTTTTTTGAGATGGAGTCAGAGTCTCACCCTGTTG
CCCAAGGTGGAGTGTAGCGGCTTGATCTCAGCTCACTGCAACCTCCCCCTCCCAAGTTCAAGCGATTCTCTGCCTCAGCCTCCCGAATAG
CTGGGATTACAGGCATCCGCTGTCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGGTTTCACCATCTTGACCAAACTGGTCTT
GAACTCTTGACCTCGTGATCCAGCTGCCTCGGCCTCTCAGAGTGTTGGGATTACAGGCGTGAGCCACCATGCCTGGCCTCTTGGAATATT
TAATAAGCTAAAAAATTCTTATACACAGGTAGATTAATTAGGTAGCCAGGAGTGGCCCCTGAAAGTATGTCTGGCAAAACCTAGAACTGC
ATCCTAGCCATCACTGTACCTTCTGCCCTCCCTGCTGTCTCCTCTGCCAGTTACAGTTAAAAGGTTGTGGGTGAGGACGCTGGGCAGAGT
CCCAGGCGTCTGCTGTCAGCTCCCCAGCCCGGCCTGCCTGCCGAGCCATCTGGGCGTCCCACGGTGGAGAGTGTGGTGCTTGTGACGCGG
TGGTGCTGGGAGCCATCCTGGTGGCAGATGTGGGCTCTCACTGCAAGTCAGTGTAAGTCCCCAGGGACTGTCAGCAGCACGTCCTGCTGC
CCCTCTCTCTGCAGAAGCCCTGGTAACCTGCGTTTGGAAAAATCTCTAAGGATTTCTGAGGAGCTGTCAGGCCATGTCCTTGTCCACCCT
GTGTGGGGCACGGCTTCGACATGGCTCTGCTCCCGTCGTGGGCTGAGAAGGAGCAGGTGGGGCTGTGCCTTGGAAAGGAGGCCCTCCCGA
CATGCCTTTGTGCGAGGTCCCTGTCCATGCTGTCTCCATCCCGGAGCCTTACGGCGATGGGTGGCCACAGAGCCTATTCCAAGAGTCTGG
TTTAGGGCTGGGTCTTCCCATCTTCACCTCTGAGTCTTAGGCGATGCGTGACCACGCAGCCCCTTCCAGGAGTCTGGTTTAGGGCTGGGT
CTTCCCATCTTCACCTCTGAGTCTTAGGCGGTGCATGACCACGCAGCCCCTTCCCGGAGTCTGGTTTAGGGCTGCGTGCTCAAGAGTCTG

>In-frame_ENST00000263097_ENST00000359060_DB278470_CNN2_chr19_1032695_+_SSU72_chr1_1500298_length(amino acids)=201AA_start in transcript=234_stop in transcript=839
MRSGPISGGGVARGARRVPTPRQPGGPVPSRPVRPRPAARPPAMSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIG
PDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQVQVSLLALAGKQTGIQRP

--------------------------------------------------------------
>In-frame_ENST00000348419_ENST00000359060_DB278470_CNN2_chr19_1032695_+_SSU72_chr1_1500298_length(transcript)=3013nt_BP=441nt
CCCGTCCCGTCCCGTCCTGTGCGGCCCCGTCCCGCCGCCCGCCCGCCAGCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGG
CTGTCGGCCGAGGTCAAGAACCGGCTCCTGTCCAAATATGACCCCCAGAAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGC
CTCTCCATCGGCCCCGACTTCCAGAAGGGCCTGAAGGATGGAACTATCTTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCC
AAGATCAACCGCTCCATGCAGAACTGGCACCAGCTAGAAAACCTGTCCAACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTG
GACCTGTTCGAGGCCAACGACCTGTTTGAGAGTGGGAACATGACGCAGGTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCAAACGGGG
ATTCAGCGTCCGATCCTTTGGAACAGGGACTCACGTGAAGCTTCCAGGACCAGCTCCCGACAAGCCCAATGTTTATGATTTCAAAACCAC
ATATGACCAGATGTACAATGATCTTCTTAGGAAAGACAAAGAACTGTATCCCAGCGGGTTGCCCTTTAAAAACCCCCCGTGTGGTCCTCC
CTGGAAGGTGTTACGTGTGGCTCGGGCACAGGAGGCGTGTCACCCTGTGCAGTGCACACACTGGCTCCTCTGTCTTTGCGAGAGCTTGGT
TTCTATTCCTGGTGCACGTCGGATCGTCCACGGGTTAGTTCCAGTGCCACCCATGGCAGTAGGCGTGGTGAGGCGCACAGACACGGTGTG
GGGTTCACCCTGACGTGGTTCAGCAGAGGGTCGTGACATAGCGTAGACCAGGGATGCTTAGGTGAGGAGGTGGAACCCACAAAATCCCAT
TGCTTTTCACACTGCAGGGCTGCCCCGTTATTTCCTTTGCAGGTTGGTGTGCGTGCGTGTGTGCGTGCGTGCCTGATACACATGGAGCCG
GGCTGCTTCACACATCTGGTGAGGTCGTTAGAAGGTCAGATAAAGAAGAGGGCGGAGCTTGCTAACCAAGCTGTTAGAAGAAATAATGGG
AGAGAACATTCCTTCATTTCAGGAGGACACAGAGCAGGCTAGGTCTGCCGCGAAGACTCCTATAGAGAGAAGAGTATTCTTAAACTAGAT
TCTGATGGACGCAACACCAGTTGCATAATGGTTATGACAATCAGTGCCCGGGTTTTTGACCAGGCATTTCATGGTCACCCCCACGCTAAT
GGAAAGTTTCTGGATCTTATTTTGTTATAGTGAGTGATTTGTAGTTTTCAGAACGGAGGCCAGGCCAAACGTATTCCAAATGAAAAGAGA
ATAGGTGTCAAATGCTAAACCTTTTATCTTCGTGTTGGCACTGTTGCCATCCCCGCCCTCTCCCGACATCCCCGCCCTTGACCAGCATCT
CTGGCCTTGCCCAGCATTGTCTATGTATTGGCACTCTTGCCATCCCCGCCCTTTCCCAGCAGAGTCTCACTGTGTCACCCCGGCTGGAGT
GCAGTGGCGAGATCTTGGCTCACTGCAGACTCACTGCAACATCCACCTCCCGGGTTCCAGTGATTCTCCTGCTTCAGCCTCCTGGGTAGC
TGGGATTACAGGCACGCGCCACCACACCTGGCTAATTTTTGTATTTTTAGTAGTCACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTAA
ACTCCTGACTTCAGGTGATCCACCCTCCTCGTCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCTCAGCCCTACTCTTGTAT
TTTTTTTTTTTTTTTTTTTTGAGATGGAGTCAGAGTCTCACCCTGTTGCCCAAGGTGGAGTGTAGCGGCTTGATCTCAGCTCACTGCAAC
CTCCCCCTCCCAAGTTCAAGCGATTCTCTGCCTCAGCCTCCCGAATAGCTGGGATTACAGGCATCCGCTGTCATGCCTGGCTAATTTTTG
TATTTTTAGTAGAGACGGGGGTTTCACCATCTTGACCAAACTGGTCTTGAACTCTTGACCTCGTGATCCAGCTGCCTCGGCCTCTCAGAG
TGTTGGGATTACAGGCGTGAGCCACCATGCCTGGCCTCTTGGAATATTTAATAAGCTAAAAAATTCTTATACACAGGTAGATTAATTAGG
TAGCCAGGAGTGGCCCCTGAAAGTATGTCTGGCAAAACCTAGAACTGCATCCTAGCCATCACTGTACCTTCTGCCCTCCCTGCTGTCTCC
TCTGCCAGTTACAGTTAAAAGGTTGTGGGTGAGGACGCTGGGCAGAGTCCCAGGCGTCTGCTGTCAGCTCCCCAGCCCGGCCTGCCTGCC
GAGCCATCTGGGCGTCCCACGGTGGAGAGTGTGGTGCTTGTGACGCGGTGGTGCTGGGAGCCATCCTGGTGGCAGATGTGGGCTCTCACT
GCAAGTCAGTGTAAGTCCCCAGGGACTGTCAGCAGCACGTCCTGCTGCCCCTCTCTCTGCAGAAGCCCTGGTAACCTGCGTTTGGAAAAA
TCTCTAAGGATTTCTGAGGAGCTGTCAGGCCATGTCCTTGTCCACCCTGTGTGGGGCACGGCTTCGACATGGCTCTGCTCCCGTCGTGGG
CTGAGAAGGAGCAGGTGGGGCTGTGCCTTGGAAAGGAGGCCCTCCCGACATGCCTTTGTGCGAGGTCCCTGTCCATGCTGTCTCCATCCC
GGAGCCTTACGGCGATGGGTGGCCACAGAGCCTATTCCAAGAGTCTGGTTTAGGGCTGGGTCTTCCCATCTTCACCTCTGAGTCTTAGGC
GATGCGTGACCACGCAGCCCCTTCCAGGAGTCTGGTTTAGGGCTGGGTCTTCCCATCTTCACCTCTGAGTCTTAGGCGGTGCATGACCAC
GCAGCCCCTTCCCGGAGTCTGGTTTAGGGCTGCGTGCTCAAGAGTCTGGTTTGGGGCTGGGTCTTCCCATCGCCCTGGAGGAGGCTTTTG

>In-frame_ENST00000348419_ENST00000359060_DB278470_CNN2_chr19_1032695_+_SSU72_chr1_1500298_length(amino acids)=158AA_start in transcript=51_stop in transcript=527
MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSN

--------------------------------------------------------------
>In-frame_ENST00000562958_ENST00000359060_DB278470_CNN2_chr19_1032695_+_SSU72_chr1_1500298_length(transcript)=2995nt_BP=423nt
GTGCGGCCCCGTCCCGCCGCCCGCCCGCCAGCCATGAGCTCCACGCAGTTCAACAAGGGCCCCTCGTACGGGCTGTCGGCCGAGGTCAAG
AACCGGCTCCTGTCCAAATATGACCCCCAGAAGGAGGCAGAGCTCCGCACCTGGATCGAGGGACTCACCGGCCTCTCCATCGGCCCCGAC
TTCCAGAAGGGCCTGAAGGATGGAACTATCTTATGCACACTCATGAACAAGCTACAGCCGGGCTCCGTCCCCAAGATCAACCGCTCCATG
CAGAACTGGCACCAGCTAGAAAACCTGTCCAACTTCATCAAGGCCATGGTCAGCTACGGCATGAACCCTGTGGACCTGTTCGAGGCCAAC
GACCTGTTTGAGAGTGGGAACATGACGCAGGTGCAGGTGTCTCTTCTCGCCCTGGCGGGGAAGCAAACGGGGATTCAGCGTCCGATCCTT
TGGAACAGGGACTCACGTGAAGCTTCCAGGACCAGCTCCCGACAAGCCCAATGTTTATGATTTCAAAACCACATATGACCAGATGTACAA
TGATCTTCTTAGGAAAGACAAAGAACTGTATCCCAGCGGGTTGCCCTTTAAAAACCCCCCGTGTGGTCCTCCCTGGAAGGTGTTACGTGT
GGCTCGGGCACAGGAGGCGTGTCACCCTGTGCAGTGCACACACTGGCTCCTCTGTCTTTGCGAGAGCTTGGTTTCTATTCCTGGTGCACG
TCGGATCGTCCACGGGTTAGTTCCAGTGCCACCCATGGCAGTAGGCGTGGTGAGGCGCACAGACACGGTGTGGGGTTCACCCTGACGTGG
TTCAGCAGAGGGTCGTGACATAGCGTAGACCAGGGATGCTTAGGTGAGGAGGTGGAACCCACAAAATCCCATTGCTTTTCACACTGCAGG
GCTGCCCCGTTATTTCCTTTGCAGGTTGGTGTGCGTGCGTGTGTGCGTGCGTGCCTGATACACATGGAGCCGGGCTGCTTCACACATCTG
GTGAGGTCGTTAGAAGGTCAGATAAAGAAGAGGGCGGAGCTTGCTAACCAAGCTGTTAGAAGAAATAATGGGAGAGAACATTCCTTCATT
TCAGGAGGACACAGAGCAGGCTAGGTCTGCCGCGAAGACTCCTATAGAGAGAAGAGTATTCTTAAACTAGATTCTGATGGACGCAACACC
AGTTGCATAATGGTTATGACAATCAGTGCCCGGGTTTTTGACCAGGCATTTCATGGTCACCCCCACGCTAATGGAAAGTTTCTGGATCTT
ATTTTGTTATAGTGAGTGATTTGTAGTTTTCAGAACGGAGGCCAGGCCAAACGTATTCCAAATGAAAAGAGAATAGGTGTCAAATGCTAA
ACCTTTTATCTTCGTGTTGGCACTGTTGCCATCCCCGCCCTCTCCCGACATCCCCGCCCTTGACCAGCATCTCTGGCCTTGCCCAGCATT
GTCTATGTATTGGCACTCTTGCCATCCCCGCCCTTTCCCAGCAGAGTCTCACTGTGTCACCCCGGCTGGAGTGCAGTGGCGAGATCTTGG
CTCACTGCAGACTCACTGCAACATCCACCTCCCGGGTTCCAGTGATTCTCCTGCTTCAGCCTCCTGGGTAGCTGGGATTACAGGCACGCG
CCACCACACCTGGCTAATTTTTGTATTTTTAGTAGTCACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTAAACTCCTGACTTCAGGTGA
TCCACCCTCCTCGTCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCTCAGCCCTACTCTTGTATTTTTTTTTTTTTTTTTTT
TTGAGATGGAGTCAGAGTCTCACCCTGTTGCCCAAGGTGGAGTGTAGCGGCTTGATCTCAGCTCACTGCAACCTCCCCCTCCCAAGTTCA
AGCGATTCTCTGCCTCAGCCTCCCGAATAGCTGGGATTACAGGCATCCGCTGTCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGG
GGGTTTCACCATCTTGACCAAACTGGTCTTGAACTCTTGACCTCGTGATCCAGCTGCCTCGGCCTCTCAGAGTGTTGGGATTACAGGCGT
GAGCCACCATGCCTGGCCTCTTGGAATATTTAATAAGCTAAAAAATTCTTATACACAGGTAGATTAATTAGGTAGCCAGGAGTGGCCCCT
GAAAGTATGTCTGGCAAAACCTAGAACTGCATCCTAGCCATCACTGTACCTTCTGCCCTCCCTGCTGTCTCCTCTGCCAGTTACAGTTAA
AAGGTTGTGGGTGAGGACGCTGGGCAGAGTCCCAGGCGTCTGCTGTCAGCTCCCCAGCCCGGCCTGCCTGCCGAGCCATCTGGGCGTCCC
ACGGTGGAGAGTGTGGTGCTTGTGACGCGGTGGTGCTGGGAGCCATCCTGGTGGCAGATGTGGGCTCTCACTGCAAGTCAGTGTAAGTCC
CCAGGGACTGTCAGCAGCACGTCCTGCTGCCCCTCTCTCTGCAGAAGCCCTGGTAACCTGCGTTTGGAAAAATCTCTAAGGATTTCTGAG
GAGCTGTCAGGCCATGTCCTTGTCCACCCTGTGTGGGGCACGGCTTCGACATGGCTCTGCTCCCGTCGTGGGCTGAGAAGGAGCAGGTGG
GGCTGTGCCTTGGAAAGGAGGCCCTCCCGACATGCCTTTGTGCGAGGTCCCTGTCCATGCTGTCTCCATCCCGGAGCCTTACGGCGATGG
GTGGCCACAGAGCCTATTCCAAGAGTCTGGTTTAGGGCTGGGTCTTCCCATCTTCACCTCTGAGTCTTAGGCGATGCGTGACCACGCAGC
CCCTTCCAGGAGTCTGGTTTAGGGCTGGGTCTTCCCATCTTCACCTCTGAGTCTTAGGCGGTGCATGACCACGCAGCCCCTTCCCGGAGT
CTGGTTTAGGGCTGCGTGCTCAAGAGTCTGGTTTGGGGCTGGGTCTTCCCATCGCCCTGGAGGAGGCTTTTGTCTCATCTCATGATTCAC

>In-frame_ENST00000562958_ENST00000359060_DB278470_CNN2_chr19_1032695_+_SSU72_chr1_1500298_length(amino acids)=158AA_start in transcript=33_stop in transcript=509
MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSN

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Fusion Gene PPI Analysis for CNN2-SSU72


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CNN2-SSU72


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CNN2-SSU72


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCNN2C0007134Renal Cell Carcinoma1CTD_human
HgeneCNN2C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneCNN2C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneCNN2C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneCNN2C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneCNN2C1306837Papillary Renal Cell Carcinoma1CTD_human