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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CNP-DNAJC7 (FusionGDB2 ID:17822)

Fusion Gene Summary for CNP-DNAJC7

check button Fusion gene summary
Fusion gene informationFusion gene name: CNP-DNAJC7
Fusion gene ID: 17822
HgeneTgene
Gene symbol

CNP

DNAJC7

Gene ID

4880

7266

Gene namenatriuretic peptide CDnaJ heat shock protein family (Hsp40) member C7
SynonymsCNP|CNP2DJ11|DJC7|TPR2|TTC2
Cytomap

2q37.1

17q21.2

Type of geneprotein-codingprotein-coding
DescriptionC-type natriuretic peptidenatriuretic peptide precursor type CdnaJ homolog subfamily C member 7DnaJ (Hsp40) homolog, subfamily C, member 7TPR repeat protein 2tetratricopeptide repeat domain 2tetratricopeptide repeat protein 2
Modification date2020031320200313
UniProtAcc.

Q99615

Ensembl transtripts involved in fusion geneENST00000393892, ENST00000472031, 
ENST00000591072, ENST00000592446, 
ENST00000393888, 		ENST00000457167, 
ENST00000426588, ENST00000316603, 
ENST00000589547, 
Fusion gene scores* DoF score5 X 6 X 4=1209 X 8 X 7=504
# samples 712
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/504*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CNP [Title/Abstract] AND DNAJC7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCNP(40125765)-DNAJC7(40139928), # samples:1
CNP(40129341)-DNAJC7(40133873), # samples:1
Anticipated loss of major functional domain due to fusion event.CNP-DNAJC7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CNP-DNAJC7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCNP

GO:0006182

cGMP biosynthetic process

1672777

HgeneCNP

GO:0006457

protein folding

16870210

HgeneCNP

GO:0007168

receptor guanylyl cyclase signaling pathway

1672777

HgeneCNP

GO:0051447

negative regulation of meiotic cell cycle

20947764

HgeneCNP

GO:1900194

negative regulation of oocyte maturation

20947764

TgeneDNAJC7

GO:0051085

chaperone cofactor-dependent protein refolding

12853476|18620420


check buttonFusion gene breakpoints across CNP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DNAJC7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4OSCNPchr17

40125765

+DNAJC7chr17

40139928

-
ChiTaRS5.0N/ABF593721CNPchr17

40129341

+DNAJC7chr17

40133873

+


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Fusion Gene ORF analysis for CNP-DNAJC7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000393892ENST00000457167CNPchr17

40125765

+DNAJC7chr17

40139928

-
In-frameENST00000393892ENST00000426588CNPchr17

40125765

+DNAJC7chr17

40139928

-
In-frameENST00000393892ENST00000316603CNPchr17

40125765

+DNAJC7chr17

40139928

-
5CDS-intronENST00000393892ENST00000589547CNPchr17

40125765

+DNAJC7chr17

40139928

-
3UTR-3CDSENST00000472031ENST00000457167CNPchr17

40125765

+DNAJC7chr17

40139928

-
3UTR-3CDSENST00000472031ENST00000426588CNPchr17

40125765

+DNAJC7chr17

40139928

-
3UTR-3CDSENST00000472031ENST00000316603CNPchr17

40125765

+DNAJC7chr17

40139928

-
3UTR-intronENST00000472031ENST00000589547CNPchr17

40125765

+DNAJC7chr17

40139928

-
Frame-shiftENST00000591072ENST00000457167CNPchr17

40125765

+DNAJC7chr17

40139928

-
Frame-shiftENST00000591072ENST00000426588CNPchr17

40125765

+DNAJC7chr17

40139928

-
Frame-shiftENST00000591072ENST00000316603CNPchr17

40125765

+DNAJC7chr17

40139928

-
5CDS-intronENST00000591072ENST00000589547CNPchr17

40125765

+DNAJC7chr17

40139928

-
intron-3CDSENST00000592446ENST00000457167CNPchr17

40125765

+DNAJC7chr17

40139928

-
intron-3CDSENST00000592446ENST00000426588CNPchr17

40125765

+DNAJC7chr17

40139928

-
intron-3CDSENST00000592446ENST00000316603CNPchr17

40125765

+DNAJC7chr17

40139928

-
intron-intronENST00000592446ENST00000589547CNPchr17

40125765

+DNAJC7chr17

40139928

-
Frame-shiftENST00000393888ENST00000457167CNPchr17

40125765

+DNAJC7chr17

40139928

-
Frame-shiftENST00000393888ENST00000426588CNPchr17

40125765

+DNAJC7chr17

40139928

-
Frame-shiftENST00000393888ENST00000316603CNPchr17

40125765

+DNAJC7chr17

40139928

-
5CDS-intronENST00000393888ENST00000589547CNPchr17

40125765

+DNAJC7chr17

40139928

-
3UTR-intronENST00000393892ENST00000457167CNPchr17

40129341

+DNAJC7chr17

40133873

+
3UTR-intronENST00000393892ENST00000426588CNPchr17

40129341

+DNAJC7chr17

40133873

+
3UTR-intronENST00000393892ENST00000316603CNPchr17

40129341

+DNAJC7chr17

40133873

+
3UTR-intronENST00000393892ENST00000589547CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000472031ENST00000457167CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000472031ENST00000426588CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000472031ENST00000316603CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000472031ENST00000589547CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000591072ENST00000457167CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000591072ENST00000426588CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000591072ENST00000316603CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000591072ENST00000589547CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000592446ENST00000457167CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000592446ENST00000426588CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000592446ENST00000316603CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000592446ENST00000589547CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000393888ENST00000457167CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000393888ENST00000426588CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000393888ENST00000316603CNPchr17

40129341

+DNAJC7chr17

40133873

+
intron-intronENST00000393888ENST00000589547CNPchr17

40129341

+DNAJC7chr17

40133873

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CNP-DNAJC7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CNP-DNAJC7


check button Go to

FGviewer for the breakpoints of chr17:40125765-chr17:40139928

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DNAJC7

Q99615

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). {ECO:0000250, ECO:0000269|PubMed:12853476, ECO:0000269|PubMed:18620420}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000316603613381_451250.0439.0DomainJ
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000426588714381_451250.0439.0DomainJ
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000457167714381_451306.0495.0DomainJ
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000316603613256_289250.0439.0RepeatNote=TPR 7
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000316603613294_327250.0439.0RepeatNote=TPR 8
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000316603613328_361250.0439.0RepeatNote=TPR 9
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000426588714256_289250.0439.0RepeatNote=TPR 7
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000426588714294_327250.0439.0RepeatNote=TPR 8
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000426588714328_361250.0439.0RepeatNote=TPR 9
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000457167714328_361306.0495.0RepeatNote=TPR 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000316603613142_175250.0439.0RepeatNote=TPR 4
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000316603613177_209250.0439.0RepeatNote=TPR 5
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000316603613210_243250.0439.0RepeatNote=TPR 6
TgeneDNAJC7chr17:40125765chr17:40139928ENST0000031660361328_61250.0439.0RepeatNote=TPR 1
TgeneDNAJC7chr17:40125765chr17:40139928ENST0000031660361362_95250.0439.0RepeatNote=TPR 2
TgeneDNAJC7chr17:40125765chr17:40139928ENST0000031660361396_129250.0439.0RepeatNote=TPR 3
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000426588714142_175250.0439.0RepeatNote=TPR 4
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000426588714177_209250.0439.0RepeatNote=TPR 5
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000426588714210_243250.0439.0RepeatNote=TPR 6
TgeneDNAJC7chr17:40125765chr17:40139928ENST0000042658871428_61250.0439.0RepeatNote=TPR 1
TgeneDNAJC7chr17:40125765chr17:40139928ENST0000042658871462_95250.0439.0RepeatNote=TPR 2
TgeneDNAJC7chr17:40125765chr17:40139928ENST0000042658871496_129250.0439.0RepeatNote=TPR 3
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000457167714142_175306.0495.0RepeatNote=TPR 4
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000457167714177_209306.0495.0RepeatNote=TPR 5
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000457167714210_243306.0495.0RepeatNote=TPR 6
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000457167714256_289306.0495.0RepeatNote=TPR 7
TgeneDNAJC7chr17:40125765chr17:40139928ENST0000045716771428_61306.0495.0RepeatNote=TPR 1
TgeneDNAJC7chr17:40125765chr17:40139928ENST00000457167714294_327306.0495.0RepeatNote=TPR 8
TgeneDNAJC7chr17:40125765chr17:40139928ENST0000045716771462_95306.0495.0RepeatNote=TPR 2
TgeneDNAJC7chr17:40125765chr17:40139928ENST0000045716771496_129306.0495.0RepeatNote=TPR 3


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Fusion Gene Sequence for CNP-DNAJC7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CNP-DNAJC7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CNP-DNAJC7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CNP-DNAJC7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCNPC0036341Schizophrenia5PSYGENET
HgeneCNPC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCNPC0041696Unipolar Depression1PSYGENET
HgeneCNPC1269683Major Depressive Disorder1PSYGENET
TgeneDNAJC7C0019693HIV Infections1CTD_human
TgeneDNAJC7C4505456HIV Coinfection1CTD_human