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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:COL27A1-CUL9 (FusionGDB2 ID:18274)

Fusion Gene Summary for COL27A1-CUL9

check button Fusion gene summary
Fusion gene informationFusion gene name: COL27A1-CUL9
Fusion gene ID: 18274
HgeneTgene
Gene symbol

COL27A1

CUL9

Gene ID

85301

23113

Gene namecollagen type XXVII alpha 1 chaincullin 9
SynonymsSTLSH7AP1|PARC
Cytomap

9q32

6p21.1

Type of geneprotein-codingprotein-coding
Descriptioncollagen alpha-1(XXVII) chaincollagen, type XXVII, alpha 1cullin-9CUL-9UbcH7-associated protein 1p53-associated parkin-like cytoplasmic proteinparkin-like cytoplasmic p53 binding protein
Modification date2020031320200320
UniProtAcc

Q8IZC6

Q8IWT3

Ensembl transtripts involved in fusion geneENST00000356083, ENST00000477421, 
ENST00000252050, ENST00000354495, 
ENST00000372647, ENST00000502937, 
Fusion gene scores* DoF score12 X 10 X 7=8406 X 6 X 4=144
# samples 126
** MAII scorelog2(12/840*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COL27A1 [Title/Abstract] AND CUL9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCOL27A1(116984547)-CUL9(43190517), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCUL9

GO:0016567

protein ubiquitination

24793696


check buttonFusion gene breakpoints across COL27A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CUL9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-FV-A495-01ACOL27A1chr9

116984547

-CUL9chr6

43190517

+


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Fusion Gene ORF analysis for COL27A1-CUL9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356083ENST00000252050COL27A1chr9

116984547

-CUL9chr6

43190517

+
In-frameENST00000356083ENST00000354495COL27A1chr9

116984547

-CUL9chr6

43190517

+
In-frameENST00000356083ENST00000372647COL27A1chr9

116984547

-CUL9chr6

43190517

+
5CDS-intronENST00000356083ENST00000502937COL27A1chr9

116984547

-CUL9chr6

43190517

+
intron-3CDSENST00000477421ENST00000252050COL27A1chr9

116984547

-CUL9chr6

43190517

+
intron-3CDSENST00000477421ENST00000354495COL27A1chr9

116984547

-CUL9chr6

43190517

+
intron-3CDSENST00000477421ENST00000372647COL27A1chr9

116984547

-CUL9chr6

43190517

+
intron-intronENST00000477421ENST00000502937COL27A1chr9

116984547

-CUL9chr6

43190517

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356083COL27A1chr9116984547-ENST00000252050CUL9chr643190517+352128573913378995
ENST00000356083COL27A1chr9116984547-ENST00000354495CUL9chr643190517+352128573913378995
ENST00000356083COL27A1chr9116984547-ENST00000372647CUL9chr643190517+351928573913378995

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356083ENST00000252050COL27A1chr9116984547-CUL9chr643190517+0.0079956930.99200433
ENST00000356083ENST00000354495COL27A1chr9116984547-CUL9chr643190517+0.0079956930.99200433
ENST00000356083ENST00000372647COL27A1chr9116984547-CUL9chr643190517+0.0080520840.99194795

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Fusion Genomic Features for COL27A1-CUL9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for COL27A1-CUL9


check button Go to

FGviewer for the breakpoints of chr9:116984547-chr6:43190517

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COL27A1

Q8IZC6

CUL9

Q8IWT3

FUNCTION: Plays a role during the calcification of cartilage and the transition of cartilage to bone. {ECO:0000269|PubMed:17693149}.FUNCTION: Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328). {ECO:0000269|PubMed:12526791, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:24793696}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-1461625_679822.01861.0DomainNote=Collagen-like 1
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-1461688_747822.01861.0DomainNote=Collagen-like 2
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-146171_236822.01861.0DomainNote=Laminin G-like
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-1461748_807822.01861.0DomainNote=Collagen-like 3
TgeneCUL9chr9:116984547chr6:43190517ENST0000025205036412365_23852344.02518.0Coiled coilOntology_term=ECO:0000255
TgeneCUL9chr9:116984547chr6:43190517ENST0000035449534392365_23852234.02408.0Coiled coilOntology_term=ECO:0000255
TgeneCUL9chr9:116984547chr6:43190517ENST0000035449534392236_22652234.02408.0Zinc fingerRING-type 2%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-1461283_1621822.01861.0Compositional biasNote=Pro-rich
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-14611003_1062822.01861.0DomainNote=Collagen-like 7
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-14611066_1125822.01861.0DomainNote=Collagen-like 8
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-14611126_1185822.01861.0DomainNote=Collagen-like 9
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-14611192_1251822.01861.0DomainNote=Collagen-like 10
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-14611258_1317822.01861.0DomainNote=Collagen-like 11
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-14611318_1378822.01861.0DomainNote=Collagen-like 12
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-14611382_1441822.01861.0DomainNote=Collagen-like 13
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-14611442_1501822.01861.0DomainNote=Collagen-like 14
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-14611502_1561822.01861.0DomainNote=Collagen-like 15
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-14611562_1621822.01861.0DomainNote=Collagen-like 16
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-14611660_1860822.01861.0DomainFibrillar collagen NC1
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-1461808_867822.01861.0DomainNote=Collagen-like 4
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-1461871_930822.01861.0DomainNote=Collagen-like 5
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-1461931_990822.01861.0DomainNote=Collagen-like 6
HgeneCOL27A1chr9:116984547chr6:43190517ENST00000356083-1461625_1618822.01861.0RegionNote=Triple-helical region
TgeneCUL9chr9:116984547chr6:43190517ENST0000025205036411649_16912344.02518.0Coiled coilOntology_term=ECO:0000255
TgeneCUL9chr9:116984547chr6:43190517ENST0000035449534391649_16912234.02408.0Coiled coilOntology_term=ECO:0000255
TgeneCUL9chr9:116984547chr6:43190517ENST0000025205036411661_16892344.02518.0Compositional biasNote=Glu-rich
TgeneCUL9chr9:116984547chr6:43190517ENST0000035449534391661_16892234.02408.0Compositional biasNote=Glu-rich
TgeneCUL9chr9:116984547chr6:43190517ENST0000025205036411143_13222344.02518.0DomainDOC
TgeneCUL9chr9:116984547chr6:43190517ENST0000035449534391143_13222234.02408.0DomainDOC
TgeneCUL9chr9:116984547chr6:43190517ENST0000025205036411363_13702344.02518.0Nucleotide bindingATP
TgeneCUL9chr9:116984547chr6:43190517ENST0000035449534391363_13702234.02408.0Nucleotide bindingATP
TgeneCUL9chr9:116984547chr6:43190517ENST0000025205036412066_22832344.02518.0RegionTRIAD supradomain
TgeneCUL9chr9:116984547chr6:43190517ENST0000035449534392066_22832234.02408.0RegionTRIAD supradomain
TgeneCUL9chr9:116984547chr6:43190517ENST0000025205036412070_21202344.02518.0Zinc fingerRING-type 1
TgeneCUL9chr9:116984547chr6:43190517ENST0000025205036412140_22032344.02518.0Zinc fingerIBR-type
TgeneCUL9chr9:116984547chr6:43190517ENST0000025205036412236_22652344.02518.0Zinc fingerRING-type 2%3B atypical
TgeneCUL9chr9:116984547chr6:43190517ENST0000035449534392070_21202234.02408.0Zinc fingerRING-type 1
TgeneCUL9chr9:116984547chr6:43190517ENST0000035449534392140_22032234.02408.0Zinc fingerIBR-type


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Fusion Gene Sequence for COL27A1-CUL9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000356083_ENST00000252050_TCGA-FV-A495-01A_COL27A1_chr9_116984547_-_CUL9_chr6_43190517_length(transcript)=3521nt_BP=2857nt
CGGCGGGGAGGCAGCTTCCACCGCCCTCCGCGCGCCCTCACCCGGCCTTGCTCTGCCTCCGGGGACCGCCAGCAGCCCGCCTCCAAAAGT
TTGATCATCTCTCTCTCTCTTTTTCTTGCTTCTTCTTCCTTTTTGGTGGAAGCAGAAAAGGACCGAGGCAGGGGCGAGCGCGGCGCCCGG
ACTCCTGGGACCATGGGCCTGGCGCGGGCGCCCGCGGGGCCCCAGCCGCGCTGCCTGCCTGCTCGGGCGCCCCTGGGCGCGGGGCTGCGC
TGGGGGCGCGGGGGCCGCGCGCTCTAAGCCGGCCTGGCGCGGCGGGGCGGGGGGCTGGCGGCCCCATGGGGCGCGCCCACACTTGCCCCC
CGGGCTCGGGAGCATGAAGTAGGGGCCTGCCATGGGAGCGGGATCGGCGCGGGGGGCCCGAGGCACAGCGGCGGCGGCGGCGGCGCGCGG
GGGGGGGTTTCTCTTCTCCTGGATCTTAGTCTCGTTTGCCTGTCACCTGGCCTCCACCCAAGGAGCTCCTGAAGATGTGGACATCCTCCA
GCGGCTGGGCCTCAGCTGGACGAAGGCCGGGAGCCCTGCACCCCCGGGAGTCATTCCTTTCCAGTCGGGCTTCATCTTTACGCAGCGGGC
CCGGCTCCAGGCTCCCACGGGCACCGTCATTCCTGCCGCCTTGGGCACAGAGCTGGCACTGGTGCTGAGCCTCTGCTCCCACCGGGTGAA
CCATGCCTTCCTCTTCGCTGTCCGCAGCCAGAAACGCAAGCTGCAGCTGGGCCTGCAGTTCCTCCCCGGCAAGACGGTCGTCCACCTCGG
GTCCCGGCGCTCAGTGGCCTTCGACCTCGACATGCACGACGGGCGCTGGCACCACCTGGCCCTCGAGCTCCGAGGCCGCACAGTCACTCT
GGTGACTGCCTGCGGGCAGCGCCGGGTGCCTGTCCTGCTGCCTTTCCACAGGGACCCTGCACTCGACCCTGGGGGCTCCTTCCTCTTTGG
GAAGATGAACCCGCATGCAGTCCAGTTTGAAGGTGCTCTCTGCCAGTTCAGTATCTACCCTGTGACGCAGGTCGCTCACAATTACTGTAC
CCACCTGAGGAAGCAGTGTGGACAGGCTGACACGTACCAGTCCCCACTGGGACCTCTCTTCTCCCAAGACTCTGGCAGACCTTTTACCTT
CCAGTCCGACCTCGCCCTGCTAGGCCTGGAGAACTTGACCACTGCCACACCAGCCCTGGGGTCACTGCCAGCAGGCAGGGGACCCAGGGG
GACTGTGGCACCCGCCACGCCCACCAAGCCCCAAAGGACTAGCCCCACAAACCCTCACCAGCATATGGCGGTGGGAGGCCCAGCCCAAAC
CCCGCTGCTACCTGCCAAGCTGTCAGCCAGTAACGCACTTGATCCCATGCTCCCAGCCTCTGTTGGCGGCTCTACCAGAACGCCTCGCCC
TGCGGCCGCTCAACCATCACAGAAGATCACAGCCACCAAAATCCCCAAAAGCCTCCCTACCAAGCCTTCGGCCCCTTCTACTTCAATTGT
GCCCATCAAAAGCCCCCATCCTACCCAGAAAACAGCTCCATCTTCATTTACAAAGTCAGCCCTACCCACTCAGAAGCAAGTGCCACCTAC
TTCCCGTCCAGTTCCTGCCAGAGTCTCCCGTCCCGCAGAGAAGCCCATCCAGAGGAACCCGGGAATGCCCAGGCCCCCACCGCCCAGCAC
CCGGCCCCTACCTCCTACCACCAGCTCCTCTAAAAAACCCATTCCCACACTAGCTCGGACTGAGGCCAAGATAACCAGCCATGCCAGTAA
GCCGGCCTCTGCCCGCACCAGCACCCACAAACCTCCCCCATTTACTGCTTTATCCTCATCTCCTGCCCCTACTCCTGGTTCTACCAGGAG
TACTCGGCCACCAGCCACGATGGTACCTCCAACTTCGGGCACCAGCACTCCCAGAACAGCACCTGCCGTCCCCACTCCTGGCTCAGCTCC
CACTGGAAGCAAGAAGCCCATTGGATCGGAAGCCTCAAAGAAAGCCGGACCCAAGAGCAGCCCCCGGAAGCCTGTCCCCCTCAGACCTGG
GAAGGCAGCCAGGGATGTCCCCTTGAGCGATCTGACAACCAGGCCTAGCCCCAGACAGCCCCAGCCCAGTCAGCAGACCACCCCGGCCCT
GGTATTGGCCCCGGCGCAATTCCTGTCCTCCAGCCCCCGGCCCACGAGCAGTGGCTATTCGATCTTCCACCTGGCAGGATCTACGCCTTT
CCCTCTGCTGATGGGGCCTCCGGGACCCAAGGGAGACTGTGGCTTGCCGGGTCCCCCTGGGCTACCTGGGCTACCTGGAATCCCTGGTGC
ACGTGGGCCTCGGGGTCCTCCTGGGCCTTATGGAAATCCAGGTCTCCCCGGCCCTCCTGGAGCCAAAGGACAGAAAGGGGACCCAGGGCT
CTCACCAGGAAAGGCCCACGATGGGGCAAAGGGTGACATGGGCTTGCCTGGGCTCTCCGGGAATCCAGGACCTCCGGGACGAAAGGGACA
CAAGGGCTATCCTGGACCGGCAGGGCACCCCGGAGAACAGGGGCAGCCAGGACCTGAGGGCAGCCCAGGGGCCAAAGGTTACCCTGGCAG
GCAGGGGTTACCTGGACCGGTAGGAGATCCCGGCCCCAAAGGCAGCAGGGGCTACATTGGGCTCCCAGGGCTCTTCGGCCTGCCAGGGTC
TGATGGAGAACGAGGCCTGCCTGGCGTTCCTGGCAAGAGGGGCAAGATGGGTATGCCGGGGTTTCCTGGAGTCTTTGGGGAAAGAGGCCC
TCCTGGACTGGATGGAAATCCTGGAGAACTGGGCCTGCCAGGCCCCCCTGGAGTCCCCGGCCTCATTGTGCTGGCCTACGCCTGCGTGTA
CAGCTTCTACAGCCAGGACGCAGAGTACATGGATGTGGTGGAGCAGCAGACAGAGAACCTGGAGCTGCACACCAATGCCCTGCAGATCCT
CCTGGAGGAAACCCTGCTGCGGTGCAGAGACCTGGCCTCCTCCCTGCGCCTCCTGCGGGCCGACTGCCTCAGCACGGGCATGGAGCTGCT
CCGGCGGATCCAGGAGAGGCTGCTTGCCATCCTGCAGCATTCTGCCCAGGATTTCCGGGTTGGTCTTCAGAGTCCATCAGTAGAGGCCTG
GGAGGCAAAAGGACCCAACATGCCTGGCAGTCAGCCCCAGGCCTCCTCAGGGCCAGAGGCAGAAGAGGAGGAGGAAGACGATGAGGATGA
TGTGCCCGAGTGGCAGCAGGATGAGTTTGATGAGGAGCTGGACAATGACAGCTTCTCCTACGATGAGTCTGAGAACCTGGACCAAGAGAC
TTTCTTCTTTGGTGATGAGGAAGAGGATGAAGATGAGGCCTATGACTGAGGGGGCAGATGCAGGAAACACCTAGAGCAGCCCCAGAGTCA
CGGGGCTGAGGGGGCGGGAGCTGCCCCTGTCATAGGGAGGGGGATTCCCAGCGTCTGTAGTGCTTCCTGTTTGCTGAATAAAGGTCTCTT

>In-frame_ENST00000356083_ENST00000252050_TCGA-FV-A495-01A_COL27A1_chr9_116984547_-_CUL9_chr6_43190517_length(amino acids)=995AA_start in transcript=391_stop in transcript=3378
MGAGSARGARGTAAAAAARGGGFLFSWILVSFACHLASTQGAPEDVDILQRLGLSWTKAGSPAPPGVIPFQSGFIFTQRARLQAPTGTVI
PAALGTELALVLSLCSHRVNHAFLFAVRSQKRKLQLGLQFLPGKTVVHLGSRRSVAFDLDMHDGRWHHLALELRGRTVTLVTACGQRRVP
VLLPFHRDPALDPGGSFLFGKMNPHAVQFEGALCQFSIYPVTQVAHNYCTHLRKQCGQADTYQSPLGPLFSQDSGRPFTFQSDLALLGLE
NLTTATPALGSLPAGRGPRGTVAPATPTKPQRTSPTNPHQHMAVGGPAQTPLLPAKLSASNALDPMLPASVGGSTRTPRPAAAQPSQKIT
ATKIPKSLPTKPSAPSTSIVPIKSPHPTQKTAPSSFTKSALPTQKQVPPTSRPVPARVSRPAEKPIQRNPGMPRPPPPSTRPLPPTTSSS
KKPIPTLARTEAKITSHASKPASARTSTHKPPPFTALSSSPAPTPGSTRSTRPPATMVPPTSGTSTPRTAPAVPTPGSAPTGSKKPIGSE
ASKKAGPKSSPRKPVPLRPGKAARDVPLSDLTTRPSPRQPQPSQQTTPALVLAPAQFLSSSPRPTSSGYSIFHLAGSTPFPLLMGPPGPK
GDCGLPGPPGLPGLPGIPGARGPRGPPGPYGNPGLPGPPGAKGQKGDPGLSPGKAHDGAKGDMGLPGLSGNPGPPGRKGHKGYPGPAGHP
GEQGQPGPEGSPGAKGYPGRQGLPGPVGDPGPKGSRGYIGLPGLFGLPGSDGERGLPGVPGKRGKMGMPGFPGVFGERGPPGLDGNPGEL
GLPGPPGVPGLIVLAYACVYSFYSQDAEYMDVVEQQTENLELHTNALQILLEETLLRCRDLASSLRLLRADCLSTGMELLRRIQERLLAI
LQHSAQDFRVGLQSPSVEAWEAKGPNMPGSQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQETFFFGDEEEDE

--------------------------------------------------------------
>In-frame_ENST00000356083_ENST00000354495_TCGA-FV-A495-01A_COL27A1_chr9_116984547_-_CUL9_chr6_43190517_length(transcript)=3521nt_BP=2857nt
CGGCGGGGAGGCAGCTTCCACCGCCCTCCGCGCGCCCTCACCCGGCCTTGCTCTGCCTCCGGGGACCGCCAGCAGCCCGCCTCCAAAAGT
TTGATCATCTCTCTCTCTCTTTTTCTTGCTTCTTCTTCCTTTTTGGTGGAAGCAGAAAAGGACCGAGGCAGGGGCGAGCGCGGCGCCCGG
ACTCCTGGGACCATGGGCCTGGCGCGGGCGCCCGCGGGGCCCCAGCCGCGCTGCCTGCCTGCTCGGGCGCCCCTGGGCGCGGGGCTGCGC
TGGGGGCGCGGGGGCCGCGCGCTCTAAGCCGGCCTGGCGCGGCGGGGCGGGGGGCTGGCGGCCCCATGGGGCGCGCCCACACTTGCCCCC
CGGGCTCGGGAGCATGAAGTAGGGGCCTGCCATGGGAGCGGGATCGGCGCGGGGGGCCCGAGGCACAGCGGCGGCGGCGGCGGCGCGCGG
GGGGGGGTTTCTCTTCTCCTGGATCTTAGTCTCGTTTGCCTGTCACCTGGCCTCCACCCAAGGAGCTCCTGAAGATGTGGACATCCTCCA
GCGGCTGGGCCTCAGCTGGACGAAGGCCGGGAGCCCTGCACCCCCGGGAGTCATTCCTTTCCAGTCGGGCTTCATCTTTACGCAGCGGGC
CCGGCTCCAGGCTCCCACGGGCACCGTCATTCCTGCCGCCTTGGGCACAGAGCTGGCACTGGTGCTGAGCCTCTGCTCCCACCGGGTGAA
CCATGCCTTCCTCTTCGCTGTCCGCAGCCAGAAACGCAAGCTGCAGCTGGGCCTGCAGTTCCTCCCCGGCAAGACGGTCGTCCACCTCGG
GTCCCGGCGCTCAGTGGCCTTCGACCTCGACATGCACGACGGGCGCTGGCACCACCTGGCCCTCGAGCTCCGAGGCCGCACAGTCACTCT
GGTGACTGCCTGCGGGCAGCGCCGGGTGCCTGTCCTGCTGCCTTTCCACAGGGACCCTGCACTCGACCCTGGGGGCTCCTTCCTCTTTGG
GAAGATGAACCCGCATGCAGTCCAGTTTGAAGGTGCTCTCTGCCAGTTCAGTATCTACCCTGTGACGCAGGTCGCTCACAATTACTGTAC
CCACCTGAGGAAGCAGTGTGGACAGGCTGACACGTACCAGTCCCCACTGGGACCTCTCTTCTCCCAAGACTCTGGCAGACCTTTTACCTT
CCAGTCCGACCTCGCCCTGCTAGGCCTGGAGAACTTGACCACTGCCACACCAGCCCTGGGGTCACTGCCAGCAGGCAGGGGACCCAGGGG
GACTGTGGCACCCGCCACGCCCACCAAGCCCCAAAGGACTAGCCCCACAAACCCTCACCAGCATATGGCGGTGGGAGGCCCAGCCCAAAC
CCCGCTGCTACCTGCCAAGCTGTCAGCCAGTAACGCACTTGATCCCATGCTCCCAGCCTCTGTTGGCGGCTCTACCAGAACGCCTCGCCC
TGCGGCCGCTCAACCATCACAGAAGATCACAGCCACCAAAATCCCCAAAAGCCTCCCTACCAAGCCTTCGGCCCCTTCTACTTCAATTGT
GCCCATCAAAAGCCCCCATCCTACCCAGAAAACAGCTCCATCTTCATTTACAAAGTCAGCCCTACCCACTCAGAAGCAAGTGCCACCTAC
TTCCCGTCCAGTTCCTGCCAGAGTCTCCCGTCCCGCAGAGAAGCCCATCCAGAGGAACCCGGGAATGCCCAGGCCCCCACCGCCCAGCAC
CCGGCCCCTACCTCCTACCACCAGCTCCTCTAAAAAACCCATTCCCACACTAGCTCGGACTGAGGCCAAGATAACCAGCCATGCCAGTAA
GCCGGCCTCTGCCCGCACCAGCACCCACAAACCTCCCCCATTTACTGCTTTATCCTCATCTCCTGCCCCTACTCCTGGTTCTACCAGGAG
TACTCGGCCACCAGCCACGATGGTACCTCCAACTTCGGGCACCAGCACTCCCAGAACAGCACCTGCCGTCCCCACTCCTGGCTCAGCTCC
CACTGGAAGCAAGAAGCCCATTGGATCGGAAGCCTCAAAGAAAGCCGGACCCAAGAGCAGCCCCCGGAAGCCTGTCCCCCTCAGACCTGG
GAAGGCAGCCAGGGATGTCCCCTTGAGCGATCTGACAACCAGGCCTAGCCCCAGACAGCCCCAGCCCAGTCAGCAGACCACCCCGGCCCT
GGTATTGGCCCCGGCGCAATTCCTGTCCTCCAGCCCCCGGCCCACGAGCAGTGGCTATTCGATCTTCCACCTGGCAGGATCTACGCCTTT
CCCTCTGCTGATGGGGCCTCCGGGACCCAAGGGAGACTGTGGCTTGCCGGGTCCCCCTGGGCTACCTGGGCTACCTGGAATCCCTGGTGC
ACGTGGGCCTCGGGGTCCTCCTGGGCCTTATGGAAATCCAGGTCTCCCCGGCCCTCCTGGAGCCAAAGGACAGAAAGGGGACCCAGGGCT
CTCACCAGGAAAGGCCCACGATGGGGCAAAGGGTGACATGGGCTTGCCTGGGCTCTCCGGGAATCCAGGACCTCCGGGACGAAAGGGACA
CAAGGGCTATCCTGGACCGGCAGGGCACCCCGGAGAACAGGGGCAGCCAGGACCTGAGGGCAGCCCAGGGGCCAAAGGTTACCCTGGCAG
GCAGGGGTTACCTGGACCGGTAGGAGATCCCGGCCCCAAAGGCAGCAGGGGCTACATTGGGCTCCCAGGGCTCTTCGGCCTGCCAGGGTC
TGATGGAGAACGAGGCCTGCCTGGCGTTCCTGGCAAGAGGGGCAAGATGGGTATGCCGGGGTTTCCTGGAGTCTTTGGGGAAAGAGGCCC
TCCTGGACTGGATGGAAATCCTGGAGAACTGGGCCTGCCAGGCCCCCCTGGAGTCCCCGGCCTCATTGTGCTGGCCTACGCCTGCGTGTA
CAGCTTCTACAGCCAGGACGCAGAGTACATGGATGTGGTGGAGCAGCAGACAGAGAACCTGGAGCTGCACACCAATGCCCTGCAGATCCT
CCTGGAGGAAACCCTGCTGCGGTGCAGAGACCTGGCCTCCTCCCTGCGCCTCCTGCGGGCCGACTGCCTCAGCACGGGCATGGAGCTGCT
CCGGCGGATCCAGGAGAGGCTGCTTGCCATCCTGCAGCATTCTGCCCAGGATTTCCGGGTTGGTCTTCAGAGTCCATCAGTAGAGGCCTG
GGAGGCAAAAGGACCCAACATGCCTGGCAGTCAGCCCCAGGCCTCCTCAGGGCCAGAGGCAGAAGAGGAGGAGGAAGACGATGAGGATGA
TGTGCCCGAGTGGCAGCAGGATGAGTTTGATGAGGAGCTGGACAATGACAGCTTCTCCTACGATGAGTCTGAGAACCTGGACCAAGAGAC
TTTCTTCTTTGGTGATGAGGAAGAGGATGAAGATGAGGCCTATGACTGAGGGGGCAGATGCAGGAAACACCTAGAGCAGCCCCAGAGTCA
CGGGGCTGAGGGGGCGGGAGCTGCCCCTGTCATAGGGAGGGGGATTCCCAGCGTCTGTAGTGCTTCCTGTTTGCTGAATAAAGGTCTCTT

>In-frame_ENST00000356083_ENST00000354495_TCGA-FV-A495-01A_COL27A1_chr9_116984547_-_CUL9_chr6_43190517_length(amino acids)=995AA_start in transcript=391_stop in transcript=3378
MGAGSARGARGTAAAAAARGGGFLFSWILVSFACHLASTQGAPEDVDILQRLGLSWTKAGSPAPPGVIPFQSGFIFTQRARLQAPTGTVI
PAALGTELALVLSLCSHRVNHAFLFAVRSQKRKLQLGLQFLPGKTVVHLGSRRSVAFDLDMHDGRWHHLALELRGRTVTLVTACGQRRVP
VLLPFHRDPALDPGGSFLFGKMNPHAVQFEGALCQFSIYPVTQVAHNYCTHLRKQCGQADTYQSPLGPLFSQDSGRPFTFQSDLALLGLE
NLTTATPALGSLPAGRGPRGTVAPATPTKPQRTSPTNPHQHMAVGGPAQTPLLPAKLSASNALDPMLPASVGGSTRTPRPAAAQPSQKIT
ATKIPKSLPTKPSAPSTSIVPIKSPHPTQKTAPSSFTKSALPTQKQVPPTSRPVPARVSRPAEKPIQRNPGMPRPPPPSTRPLPPTTSSS
KKPIPTLARTEAKITSHASKPASARTSTHKPPPFTALSSSPAPTPGSTRSTRPPATMVPPTSGTSTPRTAPAVPTPGSAPTGSKKPIGSE
ASKKAGPKSSPRKPVPLRPGKAARDVPLSDLTTRPSPRQPQPSQQTTPALVLAPAQFLSSSPRPTSSGYSIFHLAGSTPFPLLMGPPGPK
GDCGLPGPPGLPGLPGIPGARGPRGPPGPYGNPGLPGPPGAKGQKGDPGLSPGKAHDGAKGDMGLPGLSGNPGPPGRKGHKGYPGPAGHP
GEQGQPGPEGSPGAKGYPGRQGLPGPVGDPGPKGSRGYIGLPGLFGLPGSDGERGLPGVPGKRGKMGMPGFPGVFGERGPPGLDGNPGEL
GLPGPPGVPGLIVLAYACVYSFYSQDAEYMDVVEQQTENLELHTNALQILLEETLLRCRDLASSLRLLRADCLSTGMELLRRIQERLLAI
LQHSAQDFRVGLQSPSVEAWEAKGPNMPGSQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQETFFFGDEEEDE

--------------------------------------------------------------
>In-frame_ENST00000356083_ENST00000372647_TCGA-FV-A495-01A_COL27A1_chr9_116984547_-_CUL9_chr6_43190517_length(transcript)=3519nt_BP=2857nt
CGGCGGGGAGGCAGCTTCCACCGCCCTCCGCGCGCCCTCACCCGGCCTTGCTCTGCCTCCGGGGACCGCCAGCAGCCCGCCTCCAAAAGT
TTGATCATCTCTCTCTCTCTTTTTCTTGCTTCTTCTTCCTTTTTGGTGGAAGCAGAAAAGGACCGAGGCAGGGGCGAGCGCGGCGCCCGG
ACTCCTGGGACCATGGGCCTGGCGCGGGCGCCCGCGGGGCCCCAGCCGCGCTGCCTGCCTGCTCGGGCGCCCCTGGGCGCGGGGCTGCGC
TGGGGGCGCGGGGGCCGCGCGCTCTAAGCCGGCCTGGCGCGGCGGGGCGGGGGGCTGGCGGCCCCATGGGGCGCGCCCACACTTGCCCCC
CGGGCTCGGGAGCATGAAGTAGGGGCCTGCCATGGGAGCGGGATCGGCGCGGGGGGCCCGAGGCACAGCGGCGGCGGCGGCGGCGCGCGG
GGGGGGGTTTCTCTTCTCCTGGATCTTAGTCTCGTTTGCCTGTCACCTGGCCTCCACCCAAGGAGCTCCTGAAGATGTGGACATCCTCCA
GCGGCTGGGCCTCAGCTGGACGAAGGCCGGGAGCCCTGCACCCCCGGGAGTCATTCCTTTCCAGTCGGGCTTCATCTTTACGCAGCGGGC
CCGGCTCCAGGCTCCCACGGGCACCGTCATTCCTGCCGCCTTGGGCACAGAGCTGGCACTGGTGCTGAGCCTCTGCTCCCACCGGGTGAA
CCATGCCTTCCTCTTCGCTGTCCGCAGCCAGAAACGCAAGCTGCAGCTGGGCCTGCAGTTCCTCCCCGGCAAGACGGTCGTCCACCTCGG
GTCCCGGCGCTCAGTGGCCTTCGACCTCGACATGCACGACGGGCGCTGGCACCACCTGGCCCTCGAGCTCCGAGGCCGCACAGTCACTCT
GGTGACTGCCTGCGGGCAGCGCCGGGTGCCTGTCCTGCTGCCTTTCCACAGGGACCCTGCACTCGACCCTGGGGGCTCCTTCCTCTTTGG
GAAGATGAACCCGCATGCAGTCCAGTTTGAAGGTGCTCTCTGCCAGTTCAGTATCTACCCTGTGACGCAGGTCGCTCACAATTACTGTAC
CCACCTGAGGAAGCAGTGTGGACAGGCTGACACGTACCAGTCCCCACTGGGACCTCTCTTCTCCCAAGACTCTGGCAGACCTTTTACCTT
CCAGTCCGACCTCGCCCTGCTAGGCCTGGAGAACTTGACCACTGCCACACCAGCCCTGGGGTCACTGCCAGCAGGCAGGGGACCCAGGGG
GACTGTGGCACCCGCCACGCCCACCAAGCCCCAAAGGACTAGCCCCACAAACCCTCACCAGCATATGGCGGTGGGAGGCCCAGCCCAAAC
CCCGCTGCTACCTGCCAAGCTGTCAGCCAGTAACGCACTTGATCCCATGCTCCCAGCCTCTGTTGGCGGCTCTACCAGAACGCCTCGCCC
TGCGGCCGCTCAACCATCACAGAAGATCACAGCCACCAAAATCCCCAAAAGCCTCCCTACCAAGCCTTCGGCCCCTTCTACTTCAATTGT
GCCCATCAAAAGCCCCCATCCTACCCAGAAAACAGCTCCATCTTCATTTACAAAGTCAGCCCTACCCACTCAGAAGCAAGTGCCACCTAC
TTCCCGTCCAGTTCCTGCCAGAGTCTCCCGTCCCGCAGAGAAGCCCATCCAGAGGAACCCGGGAATGCCCAGGCCCCCACCGCCCAGCAC
CCGGCCCCTACCTCCTACCACCAGCTCCTCTAAAAAACCCATTCCCACACTAGCTCGGACTGAGGCCAAGATAACCAGCCATGCCAGTAA
GCCGGCCTCTGCCCGCACCAGCACCCACAAACCTCCCCCATTTACTGCTTTATCCTCATCTCCTGCCCCTACTCCTGGTTCTACCAGGAG
TACTCGGCCACCAGCCACGATGGTACCTCCAACTTCGGGCACCAGCACTCCCAGAACAGCACCTGCCGTCCCCACTCCTGGCTCAGCTCC
CACTGGAAGCAAGAAGCCCATTGGATCGGAAGCCTCAAAGAAAGCCGGACCCAAGAGCAGCCCCCGGAAGCCTGTCCCCCTCAGACCTGG
GAAGGCAGCCAGGGATGTCCCCTTGAGCGATCTGACAACCAGGCCTAGCCCCAGACAGCCCCAGCCCAGTCAGCAGACCACCCCGGCCCT
GGTATTGGCCCCGGCGCAATTCCTGTCCTCCAGCCCCCGGCCCACGAGCAGTGGCTATTCGATCTTCCACCTGGCAGGATCTACGCCTTT
CCCTCTGCTGATGGGGCCTCCGGGACCCAAGGGAGACTGTGGCTTGCCGGGTCCCCCTGGGCTACCTGGGCTACCTGGAATCCCTGGTGC
ACGTGGGCCTCGGGGTCCTCCTGGGCCTTATGGAAATCCAGGTCTCCCCGGCCCTCCTGGAGCCAAAGGACAGAAAGGGGACCCAGGGCT
CTCACCAGGAAAGGCCCACGATGGGGCAAAGGGTGACATGGGCTTGCCTGGGCTCTCCGGGAATCCAGGACCTCCGGGACGAAAGGGACA
CAAGGGCTATCCTGGACCGGCAGGGCACCCCGGAGAACAGGGGCAGCCAGGACCTGAGGGCAGCCCAGGGGCCAAAGGTTACCCTGGCAG
GCAGGGGTTACCTGGACCGGTAGGAGATCCCGGCCCCAAAGGCAGCAGGGGCTACATTGGGCTCCCAGGGCTCTTCGGCCTGCCAGGGTC
TGATGGAGAACGAGGCCTGCCTGGCGTTCCTGGCAAGAGGGGCAAGATGGGTATGCCGGGGTTTCCTGGAGTCTTTGGGGAAAGAGGCCC
TCCTGGACTGGATGGAAATCCTGGAGAACTGGGCCTGCCAGGCCCCCCTGGAGTCCCCGGCCTCATTGTGCTGGCCTACGCCTGCGTGTA
CAGCTTCTACAGCCAGGACGCAGAGTACATGGATGTGGTGGAGCAGCAGACAGAGAACCTGGAGCTGCACACCAATGCCCTGCAGATCCT
CCTGGAGGAAACCCTGCTGCGGTGCAGAGACCTGGCCTCCTCCCTGCGCCTCCTGCGGGCCGACTGCCTCAGCACGGGCATGGAGCTGCT
CCGGCGGATCCAGGAGAGGCTGCTTGCCATCCTGCAGCATTCTGCCCAGGATTTCCGGGTTGGTCTTCAGAGTCCATCAGTAGAGGCCTG
GGAGGCAAAAGGACCCAACATGCCTGGCAGTCAGCCCCAGGCCTCCTCAGGGCCAGAGGCAGAAGAGGAGGAGGAAGACGATGAGGATGA
TGTGCCCGAGTGGCAGCAGGATGAGTTTGATGAGGAGCTGGACAATGACAGCTTCTCCTACGATGAGTCTGAGAACCTGGACCAAGAGAC
TTTCTTCTTTGGTGATGAGGAAGAGGATGAAGATGAGGCCTATGACTGAGGGGGCAGATGCAGGAAACACCTAGAGCAGCCCCAGAGTCA
CGGGGCTGAGGGGGCGGGAGCTGCCCCTGTCATAGGGAGGGGGATTCCCAGCGTCTGTAGTGCTTCCTGTTTGCTGAATAAAGGTCTCTT

>In-frame_ENST00000356083_ENST00000372647_TCGA-FV-A495-01A_COL27A1_chr9_116984547_-_CUL9_chr6_43190517_length(amino acids)=995AA_start in transcript=391_stop in transcript=3378
MGAGSARGARGTAAAAAARGGGFLFSWILVSFACHLASTQGAPEDVDILQRLGLSWTKAGSPAPPGVIPFQSGFIFTQRARLQAPTGTVI
PAALGTELALVLSLCSHRVNHAFLFAVRSQKRKLQLGLQFLPGKTVVHLGSRRSVAFDLDMHDGRWHHLALELRGRTVTLVTACGQRRVP
VLLPFHRDPALDPGGSFLFGKMNPHAVQFEGALCQFSIYPVTQVAHNYCTHLRKQCGQADTYQSPLGPLFSQDSGRPFTFQSDLALLGLE
NLTTATPALGSLPAGRGPRGTVAPATPTKPQRTSPTNPHQHMAVGGPAQTPLLPAKLSASNALDPMLPASVGGSTRTPRPAAAQPSQKIT
ATKIPKSLPTKPSAPSTSIVPIKSPHPTQKTAPSSFTKSALPTQKQVPPTSRPVPARVSRPAEKPIQRNPGMPRPPPPSTRPLPPTTSSS
KKPIPTLARTEAKITSHASKPASARTSTHKPPPFTALSSSPAPTPGSTRSTRPPATMVPPTSGTSTPRTAPAVPTPGSAPTGSKKPIGSE
ASKKAGPKSSPRKPVPLRPGKAARDVPLSDLTTRPSPRQPQPSQQTTPALVLAPAQFLSSSPRPTSSGYSIFHLAGSTPFPLLMGPPGPK
GDCGLPGPPGLPGLPGIPGARGPRGPPGPYGNPGLPGPPGAKGQKGDPGLSPGKAHDGAKGDMGLPGLSGNPGPPGRKGHKGYPGPAGHP
GEQGQPGPEGSPGAKGYPGRQGLPGPVGDPGPKGSRGYIGLPGLFGLPGSDGERGLPGVPGKRGKMGMPGFPGVFGERGPPGLDGNPGEL
GLPGPPGVPGLIVLAYACVYSFYSQDAEYMDVVEQQTENLELHTNALQILLEETLLRCRDLASSLRLLRADCLSTGMELLRRIQERLLAI
LQHSAQDFRVGLQSPSVEAWEAKGPNMPGSQPQASSGPEAEEEEEDDEDDVPEWQQDEFDEELDNDSFSYDESENLDQETFFFGDEEEDE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for COL27A1-CUL9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for COL27A1-CUL9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for COL27A1-CUL9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOL27A1C3554594STEEL SYNDROME1ORPHANET;UNIPROT