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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:COL4A5-RNF128 (FusionGDB2 ID:18389) |
Fusion Gene Summary for COL4A5-RNF128 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COL4A5-RNF128 | Fusion gene ID: 18389 | Hgene | Tgene | Gene symbol | COL4A5 | RNF128 | Gene ID | 1287 | 79589 |
| Gene name | collagen type IV alpha 5 chain | ring finger protein 128 | |
| Synonyms | ASLN|ATS|ATS1|CA54 | GRAIL | |
| Cytomap | Xq22.3 | Xq22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | collagen alpha-5(IV) chaincollagen IV, alpha-5 polypeptidecollagen of basement membrane, alpha-5 chaincollagen, type IV, alpha 5dA149D17.3dA24A23.1 | E3 ubiquitin-protein ligase RNF128RING-type E3 ubiquitin transferase RNF128gene related to anergy in lymphocytes proteinring finger protein 128, E3 ubiquitin protein ligase | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000328300, ENST00000361603, ENST00000477429, | ENST00000324342, ENST00000255499, | |
| Fusion gene scores | * DoF score | 12 X 9 X 6=648 | 8 X 6 X 9=432 |
| # samples | 12 | 10 | |
| ** MAII score | log2(12/648*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: COL4A5 [Title/Abstract] AND RNF128 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | COL4A5(107829977)-RNF128(106016143), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across COL4A5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across RNF128 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-77-A5GH-01A | COL4A5 | chrX | 107829977 | - | RNF128 | chrX | 106016143 | + |
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Fusion Gene ORF analysis for COL4A5-RNF128 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000328300 | ENST00000324342 | COL4A5 | chrX | 107829977 | - | RNF128 | chrX | 106016143 | + |
| In-frame | ENST00000328300 | ENST00000255499 | COL4A5 | chrX | 107829977 | - | RNF128 | chrX | 106016143 | + |
| In-frame | ENST00000361603 | ENST00000324342 | COL4A5 | chrX | 107829977 | - | RNF128 | chrX | 106016143 | + |
| In-frame | ENST00000361603 | ENST00000255499 | COL4A5 | chrX | 107829977 | - | RNF128 | chrX | 106016143 | + |
| intron-3CDS | ENST00000477429 | ENST00000324342 | COL4A5 | chrX | 107829977 | - | RNF128 | chrX | 106016143 | + |
| intron-3CDS | ENST00000477429 | ENST00000255499 | COL4A5 | chrX | 107829977 | - | RNF128 | chrX | 106016143 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000328300 | COL4A5 | chrX | 107829977 | - | ENST00000324342 | RNF128 | chrX | 106016143 | + | 3492 | 1409 | 244 | 2211 | 655 |
| ENST00000328300 | COL4A5 | chrX | 107829977 | - | ENST00000255499 | RNF128 | chrX | 106016143 | + | 3492 | 1409 | 244 | 2211 | 655 |
| ENST00000361603 | COL4A5 | chrX | 107829977 | - | ENST00000324342 | RNF128 | chrX | 106016143 | + | 3492 | 1409 | 244 | 2211 | 655 |
| ENST00000361603 | COL4A5 | chrX | 107829977 | - | ENST00000255499 | RNF128 | chrX | 106016143 | + | 3492 | 1409 | 244 | 2211 | 655 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000328300 | ENST00000324342 | COL4A5 | chrX | 107829977 | - | RNF128 | chrX | 106016143 | + | 0.000150361 | 0.99984956 |
| ENST00000328300 | ENST00000255499 | COL4A5 | chrX | 107829977 | - | RNF128 | chrX | 106016143 | + | 0.000150361 | 0.99984956 |
| ENST00000361603 | ENST00000324342 | COL4A5 | chrX | 107829977 | - | RNF128 | chrX | 106016143 | + | 0.000150361 | 0.99984956 |
| ENST00000361603 | ENST00000255499 | COL4A5 | chrX | 107829977 | - | RNF128 | chrX | 106016143 | + | 0.000150361 | 0.99984956 |
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Fusion Genomic Features for COL4A5-RNF128 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for COL4A5-RNF128 |
| Go to FGviewer for the breakpoints of chrX:107829977-chrX:106016143 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | COL4A5 | chrX:107829977 | chrX:106016143 | ENST00000328300 | - | 19 | 53 | 27_41 | 388.3333333333333 | 1692.0 | Region | Note=Nonhelical region (NC2) |
| Hgene | COL4A5 | chrX:107829977 | chrX:106016143 | ENST00000361603 | - | 19 | 51 | 27_41 | 388.3333333333333 | 1686.0 | Region | Note=Nonhelical region (NC2) |
| Tgene | RNF128 | chrX:107829977 | chrX:106016143 | ENST00000255499 | 0 | 7 | 208_228 | 161.33333333333334 | 429.0 | Transmembrane | Helical | |
| Tgene | RNF128 | chrX:107829977 | chrX:106016143 | ENST00000324342 | 0 | 7 | 208_228 | 135.33333333333334 | 403.0 | Transmembrane | Helical | |
| Tgene | RNF128 | chrX:107829977 | chrX:106016143 | ENST00000255499 | 0 | 7 | 277_318 | 161.33333333333334 | 429.0 | Zinc finger | RING-type%3B atypical | |
| Tgene | RNF128 | chrX:107829977 | chrX:106016143 | ENST00000324342 | 0 | 7 | 277_318 | 135.33333333333334 | 403.0 | Zinc finger | RING-type%3B atypical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | COL4A5 | chrX:107829977 | chrX:106016143 | ENST00000328300 | - | 19 | 53 | 1461_1685 | 388.3333333333333 | 1692.0 | Domain | Collagen IV NC1 |
| Hgene | COL4A5 | chrX:107829977 | chrX:106016143 | ENST00000361603 | - | 19 | 51 | 1461_1685 | 388.3333333333333 | 1686.0 | Domain | Collagen IV NC1 |
| Hgene | COL4A5 | chrX:107829977 | chrX:106016143 | ENST00000328300 | - | 19 | 53 | 42_1456 | 388.3333333333333 | 1692.0 | Region | Note=Triple-helical region |
| Hgene | COL4A5 | chrX:107829977 | chrX:106016143 | ENST00000361603 | - | 19 | 51 | 42_1456 | 388.3333333333333 | 1686.0 | Region | Note=Triple-helical region |
| Tgene | RNF128 | chrX:107829977 | chrX:106016143 | ENST00000255499 | 0 | 7 | 75_183 | 161.33333333333334 | 429.0 | Domain | Note=PA | |
| Tgene | RNF128 | chrX:107829977 | chrX:106016143 | ENST00000324342 | 0 | 7 | 75_183 | 135.33333333333334 | 403.0 | Domain | Note=PA |
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Fusion Gene Sequence for COL4A5-RNF128 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000328300_ENST00000324342_TCGA-77-A5GH-01A_COL4A5_chrX_107829977_-_RNF128_chrX_106016143_length(transcript)=3492nt_BP=1409nt AGAAGGGAAAAGTTCTCCTGAGAGACCGGCTTTGGGGAGGGGAGGGGGGAAGGAAGAGTAGCTCCTTCTTCTTCTTCTTTTTTTTTTCTT CCACTCTTAAAAAGCTTCTTTCTCTTCACCCAAGCCTCACTGTCCCTCTCCGGCTCTAGCTCTCTCCATATAAACCCTCAAGATTATGTC AATTGGTTAGAGCCAGCCGGGAATTTCGTGCGGGTGCTGAAGGAGCTGCGGGAGCCGGAGAAGAATGAAACTGCGTGGAGTCAGCCTGGC TGCCGGCTTGTTCTTACTGGCCCTGAGTCTTTGGGGGCAGCCTGCAGAGGCTGCGGCTTGCTATGGGTGTTCTCCAGGATCAAAGTGTGA CTGCAGTGGCATAAAAGGGGAAAAGGGAGAGAGAGGGTTTCCAGGTTTGGAAGGACACCCAGGATTGCCTGGATTTCCAGGTCCAGAAGG GCCTCCGGGGCCTCGGGGACAAAAGGGTGATGATGGAATTCCAGGGCCACCAGGACCAAAAGGAATCAGAGGTCCTCCTGGACTTCCTGG ATTTCCAGGGACACCAGGTCTTCCTGGAATGCCAGGCCACGATGGGGCCCCAGGACCTCAAGGTATTCCCGGATGCAATGGAACCAAGGG AGAACGTGGATTTCCAGGCAGTCCCGGTTTTCCTGGTTTACAGGGTCCTCCAGGACCCCCTGGGATCCCAGGTATGAAGGGTGAACCAGG TAGTATAATTATGTCATCACTGCCAGGACCAAAGGGTAATCCAGGATATCCAGGTCCTCCTGGAATACAAGGCCTACCTGGTCCCACTGG TATACCAGGGCCAATTGGTCCCCCAGGACCACCAGGTTTGATGGGCCCTCCTGGTCCACCAGGACTTCCAGGACCTAAGGGGAATATGGG CTTAAATTTCCAGGGACCCAAAGGTGAAAAAGGTGAGCAAGGTCTTCAGGGCCCACCTGGGCCACCTGGGCAGATCAGTGAACAGAAAAG ACCAATTGATGTAGAGTTTCAGAAAGGAGATCAGGGACTTCCTGGTGACCGAGGGCCTCCTGGACCTCCAGGGATACGTGGTCCTCCAGG TCCCCCAGGTGGTGAGAAAGGTGAGAAGGGTGAGCAAGGAGAGCCAGGCAAAAGAGGTAAACCAGGCAAAGATGGAGAAAATGGCCAACC AGGAATTCCTGGTTTGCCTGGTGATCCTGGTTACCCTGGTGAACCCGGAAGGGATGGTGAAAAGGGCCAAAAAGGTGACACTGGCCCACC TGGACCTCCTGGACTTGTAATTCCTAGACCTGGGACTGGTATAACTATAGGAGAAAAAGGAAACATTGGGTTGCCTGGGTTGCCTGGAGA AAAAGGAGAGCGAGGATTTCCTGGAATACAGGGTCCACCTGGCCTTCCTGGACCTCCAGGTGCAGTAGACATTGTTGCAATCATGATCGG CAATCTGAAAGGCACAAAAATTCTGCAATCTATTCAAAGAGGCATACAAGTGACAATGGTCATAGAAGTAGGGAAAAAACATGGCCCTTG GGTGAATCACTATTCAATTTTTTTCGTTTCTGTGTCCTTTTTTATTATTACGGCGGCAACTGTGGGCTATTTTATCTTTTATTCTGCTCG AAGGCTACGGAATGCAAGAGCTCAAAGCAGGAAGCAGAGGCAATTAAAGGCAGATGCTAAAAAAGCTATTGGAAGGCTTCAACTACGCAC ACTGAAACAAGGAGACAAGGAAATTGGCCCTGATGGAGATAGTTGTGCTGTGTGCATTGAATTGTATAAACCAAATGATTTGGTACGCAT CTTAACGTGCAACCATATTTTCCATAAGACATGTGTTGACCCATGGCTGTTAGAACACAGGACTTGCCCCATGTGCAAATGTGACATACT CAAAGCTTTGGGAATTGAGGTGGATGTTGAAGATGGATCAGTGTCTTTACAAGTCCCTGTATCCAATGAAATATCTAATAGTGCCTCCTC CCATGAAGAGGATAATCGCAGCGAGACCGCATCATCTGGATATGCTTCAGTACAGGGAACAGATGAACCGCCTCTGGAGGAACACGTGCA GTCAACAAATGAAAGTCTACAGCTGGTAAACCATGAAGCAAATTCTGTGGCAGTGGATGTTATTCCTCATGTTGACAACCCAACCTTTGA AGAAGACGAAACTCCTAATCAAGAGACTGCTGTTCGAGAAATTAAATCTTAAAATCTGTGTAAATAGAAAACTTGAACCATTAGTAATAA CAGAACTGCCAATCAGGGCCTAGTTTCTATTAATAAATTGGATAAATTTAATAAAATAAGAGTGATACTGAAAGTGCTCAGATGACTAAT ATTATGCTATAGTTAAATGGCTTAAAATATTTAACCTGTTAACTTTTTTCCACAAACTCATTATAATATTTTTCATAGGCAAGTTTCCTC TCAGTAGTGATAACAACATTTTTAGACATTCAAAACTGTCTTCAAGAAGTCACGTTTTTCATTTATAACAATTTTCTTATAAAAACATGT TGCTTTTAAAATGTGGAGTAGCTGTAATCACTTTATTTTATGATAGTATCTTAATGAAAAATACTACTTCTTTAGCTTGGGCTACATGTG TCAGGGTTTTTCTCCAGGTGCTTATATTGATCTGGAATTGTAATGTAAAAAGCAATGCAAACTTAGGCGAGTACTTCTTGAAATGTCTAT TTAAGCTGCTTTAAGTTAATAGAAAAGATTAAAGCAAAATATTCATTTTTACTTTTTCTTATTTTTAAAATTAGGCTGAATGTACTTCAT GTGATTTGTCAACCATAGTTTATCAGAGATTATGGACTTAATTGATTGGTATATTAGTGACATCAACTTGACACAAGATTAGACAAAAAA TTCCTTACAAAAATACTGTGTAACTATTTCTCAAACTTGTGGGATTTTTCAAAAGCTCAGTATATGAATCATCATACTGTTTGAAATTGC TAATGACAGAGTAAGTAACACTAATATTGGTCATTGATCTTCGTTCATGAATTAGTCTACAGAAAAAAAATGTTCTGTAAAATTAGTCTG TTGAAAATGTTTTCCAAACAATGTTACTTTGAAAATTGAGTTTATGTTTGACCTAAATGGGCTAAAATTACATTAGATAAACTAAAATTC TGTCCGTGTAACTATAAATTTTGTGAATGCATTTTCCTGGTGTTTGAAAAAGAAGGGGGGGAGAATTCCAGGTGCCTTAATATAAAGTTT GAAGCTTCATCCACCAAAGTTAAATAGAGCTATTTAAAAATGCACTTTATTTGTACTCTGTGTGGCTTTTGTTTTAGAATTTTGTTCAAA TTATAGCAGAATTTAGGCAAAAATAAAACAGACATGTATTTTTGTTTGCTGAATGGATGAAACCATTGCATTCTTGTACACTGATTTGAA >In-frame_ENST00000328300_ENST00000324342_TCGA-77-A5GH-01A_COL4A5_chrX_107829977_-_RNF128_chrX_106016143_length(amino acids)=655AA_start in transcript=244_stop in transcript=2211 MKLRGVSLAAGLFLLALSLWGQPAEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHPGLPGFPGPEGPPGPRGQKGDDGIPGPPGPKG IRGPPGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYPGPPG IQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPG PPGIRGPPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRDGEKGQKGDTGPPGPPGLVIPRPGTGITIGEKGN IGLPGLPGEKGERGFPGIQGPPGLPGPPGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATV GYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRT CPMCKCDILKALGIEVDVEDGSVSLQVPVSNEISNSASSHEEDNRSETASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEANSVAVDVI -------------------------------------------------------------- >In-frame_ENST00000328300_ENST00000255499_TCGA-77-A5GH-01A_COL4A5_chrX_107829977_-_RNF128_chrX_106016143_length(transcript)=3492nt_BP=1409nt AGAAGGGAAAAGTTCTCCTGAGAGACCGGCTTTGGGGAGGGGAGGGGGGAAGGAAGAGTAGCTCCTTCTTCTTCTTCTTTTTTTTTTCTT CCACTCTTAAAAAGCTTCTTTCTCTTCACCCAAGCCTCACTGTCCCTCTCCGGCTCTAGCTCTCTCCATATAAACCCTCAAGATTATGTC AATTGGTTAGAGCCAGCCGGGAATTTCGTGCGGGTGCTGAAGGAGCTGCGGGAGCCGGAGAAGAATGAAACTGCGTGGAGTCAGCCTGGC TGCCGGCTTGTTCTTACTGGCCCTGAGTCTTTGGGGGCAGCCTGCAGAGGCTGCGGCTTGCTATGGGTGTTCTCCAGGATCAAAGTGTGA CTGCAGTGGCATAAAAGGGGAAAAGGGAGAGAGAGGGTTTCCAGGTTTGGAAGGACACCCAGGATTGCCTGGATTTCCAGGTCCAGAAGG GCCTCCGGGGCCTCGGGGACAAAAGGGTGATGATGGAATTCCAGGGCCACCAGGACCAAAAGGAATCAGAGGTCCTCCTGGACTTCCTGG ATTTCCAGGGACACCAGGTCTTCCTGGAATGCCAGGCCACGATGGGGCCCCAGGACCTCAAGGTATTCCCGGATGCAATGGAACCAAGGG AGAACGTGGATTTCCAGGCAGTCCCGGTTTTCCTGGTTTACAGGGTCCTCCAGGACCCCCTGGGATCCCAGGTATGAAGGGTGAACCAGG TAGTATAATTATGTCATCACTGCCAGGACCAAAGGGTAATCCAGGATATCCAGGTCCTCCTGGAATACAAGGCCTACCTGGTCCCACTGG TATACCAGGGCCAATTGGTCCCCCAGGACCACCAGGTTTGATGGGCCCTCCTGGTCCACCAGGACTTCCAGGACCTAAGGGGAATATGGG CTTAAATTTCCAGGGACCCAAAGGTGAAAAAGGTGAGCAAGGTCTTCAGGGCCCACCTGGGCCACCTGGGCAGATCAGTGAACAGAAAAG ACCAATTGATGTAGAGTTTCAGAAAGGAGATCAGGGACTTCCTGGTGACCGAGGGCCTCCTGGACCTCCAGGGATACGTGGTCCTCCAGG TCCCCCAGGTGGTGAGAAAGGTGAGAAGGGTGAGCAAGGAGAGCCAGGCAAAAGAGGTAAACCAGGCAAAGATGGAGAAAATGGCCAACC AGGAATTCCTGGTTTGCCTGGTGATCCTGGTTACCCTGGTGAACCCGGAAGGGATGGTGAAAAGGGCCAAAAAGGTGACACTGGCCCACC TGGACCTCCTGGACTTGTAATTCCTAGACCTGGGACTGGTATAACTATAGGAGAAAAAGGAAACATTGGGTTGCCTGGGTTGCCTGGAGA AAAAGGAGAGCGAGGATTTCCTGGAATACAGGGTCCACCTGGCCTTCCTGGACCTCCAGGTGCAGTAGACATTGTTGCAATCATGATCGG CAATCTGAAAGGCACAAAAATTCTGCAATCTATTCAAAGAGGCATACAAGTGACAATGGTCATAGAAGTAGGGAAAAAACATGGCCCTTG GGTGAATCACTATTCAATTTTTTTCGTTTCTGTGTCCTTTTTTATTATTACGGCGGCAACTGTGGGCTATTTTATCTTTTATTCTGCTCG AAGGCTACGGAATGCAAGAGCTCAAAGCAGGAAGCAGAGGCAATTAAAGGCAGATGCTAAAAAAGCTATTGGAAGGCTTCAACTACGCAC ACTGAAACAAGGAGACAAGGAAATTGGCCCTGATGGAGATAGTTGTGCTGTGTGCATTGAATTGTATAAACCAAATGATTTGGTACGCAT CTTAACGTGCAACCATATTTTCCATAAGACATGTGTTGACCCATGGCTGTTAGAACACAGGACTTGCCCCATGTGCAAATGTGACATACT CAAAGCTTTGGGAATTGAGGTGGATGTTGAAGATGGATCAGTGTCTTTACAAGTCCCTGTATCCAATGAAATATCTAATAGTGCCTCCTC CCATGAAGAGGATAATCGCAGCGAGACCGCATCATCTGGATATGCTTCAGTACAGGGAACAGATGAACCGCCTCTGGAGGAACACGTGCA GTCAACAAATGAAAGTCTACAGCTGGTAAACCATGAAGCAAATTCTGTGGCAGTGGATGTTATTCCTCATGTTGACAACCCAACCTTTGA AGAAGACGAAACTCCTAATCAAGAGACTGCTGTTCGAGAAATTAAATCTTAAAATCTGTGTAAATAGAAAACTTGAACCATTAGTAATAA CAGAACTGCCAATCAGGGCCTAGTTTCTATTAATAAATTGGATAAATTTAATAAAATAAGAGTGATACTGAAAGTGCTCAGATGACTAAT ATTATGCTATAGTTAAATGGCTTAAAATATTTAACCTGTTAACTTTTTTCCACAAACTCATTATAATATTTTTCATAGGCAAGTTTCCTC TCAGTAGTGATAACAACATTTTTAGACATTCAAAACTGTCTTCAAGAAGTCACGTTTTTCATTTATAACAATTTTCTTATAAAAACATGT TGCTTTTAAAATGTGGAGTAGCTGTAATCACTTTATTTTATGATAGTATCTTAATGAAAAATACTACTTCTTTAGCTTGGGCTACATGTG TCAGGGTTTTTCTCCAGGTGCTTATATTGATCTGGAATTGTAATGTAAAAAGCAATGCAAACTTAGGCGAGTACTTCTTGAAATGTCTAT TTAAGCTGCTTTAAGTTAATAGAAAAGATTAAAGCAAAATATTCATTTTTACTTTTTCTTATTTTTAAAATTAGGCTGAATGTACTTCAT GTGATTTGTCAACCATAGTTTATCAGAGATTATGGACTTAATTGATTGGTATATTAGTGACATCAACTTGACACAAGATTAGACAAAAAA TTCCTTACAAAAATACTGTGTAACTATTTCTCAAACTTGTGGGATTTTTCAAAAGCTCAGTATATGAATCATCATACTGTTTGAAATTGC TAATGACAGAGTAAGTAACACTAATATTGGTCATTGATCTTCGTTCATGAATTAGTCTACAGAAAAAAAATGTTCTGTAAAATTAGTCTG TTGAAAATGTTTTCCAAACAATGTTACTTTGAAAATTGAGTTTATGTTTGACCTAAATGGGCTAAAATTACATTAGATAAACTAAAATTC TGTCCGTGTAACTATAAATTTTGTGAATGCATTTTCCTGGTGTTTGAAAAAGAAGGGGGGGAGAATTCCAGGTGCCTTAATATAAAGTTT GAAGCTTCATCCACCAAAGTTAAATAGAGCTATTTAAAAATGCACTTTATTTGTACTCTGTGTGGCTTTTGTTTTAGAATTTTGTTCAAA TTATAGCAGAATTTAGGCAAAAATAAAACAGACATGTATTTTTGTTTGCTGAATGGATGAAACCATTGCATTCTTGTACACTGATTTGAA >In-frame_ENST00000328300_ENST00000255499_TCGA-77-A5GH-01A_COL4A5_chrX_107829977_-_RNF128_chrX_106016143_length(amino acids)=655AA_start in transcript=244_stop in transcript=2211 MKLRGVSLAAGLFLLALSLWGQPAEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHPGLPGFPGPEGPPGPRGQKGDDGIPGPPGPKG IRGPPGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYPGPPG IQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPG PPGIRGPPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRDGEKGQKGDTGPPGPPGLVIPRPGTGITIGEKGN IGLPGLPGEKGERGFPGIQGPPGLPGPPGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATV GYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRT CPMCKCDILKALGIEVDVEDGSVSLQVPVSNEISNSASSHEEDNRSETASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEANSVAVDVI -------------------------------------------------------------- >In-frame_ENST00000361603_ENST00000324342_TCGA-77-A5GH-01A_COL4A5_chrX_107829977_-_RNF128_chrX_106016143_length(transcript)=3492nt_BP=1409nt AGAAGGGAAAAGTTCTCCTGAGAGACCGGCTTTGGGGAGGGGAGGGGGGAAGGAAGAGTAGCTCCTTCTTCTTCTTCTTTTTTTTTTCTT CCACTCTTAAAAAGCTTCTTTCTCTTCACCCAAGCCTCACTGTCCCTCTCCGGCTCTAGCTCTCTCCATATAAACCCTCAAGATTATGTC AATTGGTTAGAGCCAGCCGGGAATTTCGTGCGGGTGCTGAAGGAGCTGCGGGAGCCGGAGAAGAATGAAACTGCGTGGAGTCAGCCTGGC TGCCGGCTTGTTCTTACTGGCCCTGAGTCTTTGGGGGCAGCCTGCAGAGGCTGCGGCTTGCTATGGGTGTTCTCCAGGATCAAAGTGTGA CTGCAGTGGCATAAAAGGGGAAAAGGGAGAGAGAGGGTTTCCAGGTTTGGAAGGACACCCAGGATTGCCTGGATTTCCAGGTCCAGAAGG GCCTCCGGGGCCTCGGGGACAAAAGGGTGATGATGGAATTCCAGGGCCACCAGGACCAAAAGGAATCAGAGGTCCTCCTGGACTTCCTGG ATTTCCAGGGACACCAGGTCTTCCTGGAATGCCAGGCCACGATGGGGCCCCAGGACCTCAAGGTATTCCCGGATGCAATGGAACCAAGGG AGAACGTGGATTTCCAGGCAGTCCCGGTTTTCCTGGTTTACAGGGTCCTCCAGGACCCCCTGGGATCCCAGGTATGAAGGGTGAACCAGG TAGTATAATTATGTCATCACTGCCAGGACCAAAGGGTAATCCAGGATATCCAGGTCCTCCTGGAATACAAGGCCTACCTGGTCCCACTGG TATACCAGGGCCAATTGGTCCCCCAGGACCACCAGGTTTGATGGGCCCTCCTGGTCCACCAGGACTTCCAGGACCTAAGGGGAATATGGG CTTAAATTTCCAGGGACCCAAAGGTGAAAAAGGTGAGCAAGGTCTTCAGGGCCCACCTGGGCCACCTGGGCAGATCAGTGAACAGAAAAG ACCAATTGATGTAGAGTTTCAGAAAGGAGATCAGGGACTTCCTGGTGACCGAGGGCCTCCTGGACCTCCAGGGATACGTGGTCCTCCAGG TCCCCCAGGTGGTGAGAAAGGTGAGAAGGGTGAGCAAGGAGAGCCAGGCAAAAGAGGTAAACCAGGCAAAGATGGAGAAAATGGCCAACC AGGAATTCCTGGTTTGCCTGGTGATCCTGGTTACCCTGGTGAACCCGGAAGGGATGGTGAAAAGGGCCAAAAAGGTGACACTGGCCCACC TGGACCTCCTGGACTTGTAATTCCTAGACCTGGGACTGGTATAACTATAGGAGAAAAAGGAAACATTGGGTTGCCTGGGTTGCCTGGAGA AAAAGGAGAGCGAGGATTTCCTGGAATACAGGGTCCACCTGGCCTTCCTGGACCTCCAGGTGCAGTAGACATTGTTGCAATCATGATCGG CAATCTGAAAGGCACAAAAATTCTGCAATCTATTCAAAGAGGCATACAAGTGACAATGGTCATAGAAGTAGGGAAAAAACATGGCCCTTG GGTGAATCACTATTCAATTTTTTTCGTTTCTGTGTCCTTTTTTATTATTACGGCGGCAACTGTGGGCTATTTTATCTTTTATTCTGCTCG AAGGCTACGGAATGCAAGAGCTCAAAGCAGGAAGCAGAGGCAATTAAAGGCAGATGCTAAAAAAGCTATTGGAAGGCTTCAACTACGCAC ACTGAAACAAGGAGACAAGGAAATTGGCCCTGATGGAGATAGTTGTGCTGTGTGCATTGAATTGTATAAACCAAATGATTTGGTACGCAT CTTAACGTGCAACCATATTTTCCATAAGACATGTGTTGACCCATGGCTGTTAGAACACAGGACTTGCCCCATGTGCAAATGTGACATACT CAAAGCTTTGGGAATTGAGGTGGATGTTGAAGATGGATCAGTGTCTTTACAAGTCCCTGTATCCAATGAAATATCTAATAGTGCCTCCTC CCATGAAGAGGATAATCGCAGCGAGACCGCATCATCTGGATATGCTTCAGTACAGGGAACAGATGAACCGCCTCTGGAGGAACACGTGCA GTCAACAAATGAAAGTCTACAGCTGGTAAACCATGAAGCAAATTCTGTGGCAGTGGATGTTATTCCTCATGTTGACAACCCAACCTTTGA AGAAGACGAAACTCCTAATCAAGAGACTGCTGTTCGAGAAATTAAATCTTAAAATCTGTGTAAATAGAAAACTTGAACCATTAGTAATAA CAGAACTGCCAATCAGGGCCTAGTTTCTATTAATAAATTGGATAAATTTAATAAAATAAGAGTGATACTGAAAGTGCTCAGATGACTAAT ATTATGCTATAGTTAAATGGCTTAAAATATTTAACCTGTTAACTTTTTTCCACAAACTCATTATAATATTTTTCATAGGCAAGTTTCCTC TCAGTAGTGATAACAACATTTTTAGACATTCAAAACTGTCTTCAAGAAGTCACGTTTTTCATTTATAACAATTTTCTTATAAAAACATGT TGCTTTTAAAATGTGGAGTAGCTGTAATCACTTTATTTTATGATAGTATCTTAATGAAAAATACTACTTCTTTAGCTTGGGCTACATGTG TCAGGGTTTTTCTCCAGGTGCTTATATTGATCTGGAATTGTAATGTAAAAAGCAATGCAAACTTAGGCGAGTACTTCTTGAAATGTCTAT TTAAGCTGCTTTAAGTTAATAGAAAAGATTAAAGCAAAATATTCATTTTTACTTTTTCTTATTTTTAAAATTAGGCTGAATGTACTTCAT GTGATTTGTCAACCATAGTTTATCAGAGATTATGGACTTAATTGATTGGTATATTAGTGACATCAACTTGACACAAGATTAGACAAAAAA TTCCTTACAAAAATACTGTGTAACTATTTCTCAAACTTGTGGGATTTTTCAAAAGCTCAGTATATGAATCATCATACTGTTTGAAATTGC TAATGACAGAGTAAGTAACACTAATATTGGTCATTGATCTTCGTTCATGAATTAGTCTACAGAAAAAAAATGTTCTGTAAAATTAGTCTG TTGAAAATGTTTTCCAAACAATGTTACTTTGAAAATTGAGTTTATGTTTGACCTAAATGGGCTAAAATTACATTAGATAAACTAAAATTC TGTCCGTGTAACTATAAATTTTGTGAATGCATTTTCCTGGTGTTTGAAAAAGAAGGGGGGGAGAATTCCAGGTGCCTTAATATAAAGTTT GAAGCTTCATCCACCAAAGTTAAATAGAGCTATTTAAAAATGCACTTTATTTGTACTCTGTGTGGCTTTTGTTTTAGAATTTTGTTCAAA TTATAGCAGAATTTAGGCAAAAATAAAACAGACATGTATTTTTGTTTGCTGAATGGATGAAACCATTGCATTCTTGTACACTGATTTGAA >In-frame_ENST00000361603_ENST00000324342_TCGA-77-A5GH-01A_COL4A5_chrX_107829977_-_RNF128_chrX_106016143_length(amino acids)=655AA_start in transcript=244_stop in transcript=2211 MKLRGVSLAAGLFLLALSLWGQPAEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHPGLPGFPGPEGPPGPRGQKGDDGIPGPPGPKG IRGPPGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYPGPPG IQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPG PPGIRGPPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRDGEKGQKGDTGPPGPPGLVIPRPGTGITIGEKGN IGLPGLPGEKGERGFPGIQGPPGLPGPPGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATV GYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRT CPMCKCDILKALGIEVDVEDGSVSLQVPVSNEISNSASSHEEDNRSETASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEANSVAVDVI -------------------------------------------------------------- >In-frame_ENST00000361603_ENST00000255499_TCGA-77-A5GH-01A_COL4A5_chrX_107829977_-_RNF128_chrX_106016143_length(transcript)=3492nt_BP=1409nt AGAAGGGAAAAGTTCTCCTGAGAGACCGGCTTTGGGGAGGGGAGGGGGGAAGGAAGAGTAGCTCCTTCTTCTTCTTCTTTTTTTTTTCTT CCACTCTTAAAAAGCTTCTTTCTCTTCACCCAAGCCTCACTGTCCCTCTCCGGCTCTAGCTCTCTCCATATAAACCCTCAAGATTATGTC AATTGGTTAGAGCCAGCCGGGAATTTCGTGCGGGTGCTGAAGGAGCTGCGGGAGCCGGAGAAGAATGAAACTGCGTGGAGTCAGCCTGGC TGCCGGCTTGTTCTTACTGGCCCTGAGTCTTTGGGGGCAGCCTGCAGAGGCTGCGGCTTGCTATGGGTGTTCTCCAGGATCAAAGTGTGA CTGCAGTGGCATAAAAGGGGAAAAGGGAGAGAGAGGGTTTCCAGGTTTGGAAGGACACCCAGGATTGCCTGGATTTCCAGGTCCAGAAGG GCCTCCGGGGCCTCGGGGACAAAAGGGTGATGATGGAATTCCAGGGCCACCAGGACCAAAAGGAATCAGAGGTCCTCCTGGACTTCCTGG ATTTCCAGGGACACCAGGTCTTCCTGGAATGCCAGGCCACGATGGGGCCCCAGGACCTCAAGGTATTCCCGGATGCAATGGAACCAAGGG AGAACGTGGATTTCCAGGCAGTCCCGGTTTTCCTGGTTTACAGGGTCCTCCAGGACCCCCTGGGATCCCAGGTATGAAGGGTGAACCAGG TAGTATAATTATGTCATCACTGCCAGGACCAAAGGGTAATCCAGGATATCCAGGTCCTCCTGGAATACAAGGCCTACCTGGTCCCACTGG TATACCAGGGCCAATTGGTCCCCCAGGACCACCAGGTTTGATGGGCCCTCCTGGTCCACCAGGACTTCCAGGACCTAAGGGGAATATGGG CTTAAATTTCCAGGGACCCAAAGGTGAAAAAGGTGAGCAAGGTCTTCAGGGCCCACCTGGGCCACCTGGGCAGATCAGTGAACAGAAAAG ACCAATTGATGTAGAGTTTCAGAAAGGAGATCAGGGACTTCCTGGTGACCGAGGGCCTCCTGGACCTCCAGGGATACGTGGTCCTCCAGG TCCCCCAGGTGGTGAGAAAGGTGAGAAGGGTGAGCAAGGAGAGCCAGGCAAAAGAGGTAAACCAGGCAAAGATGGAGAAAATGGCCAACC AGGAATTCCTGGTTTGCCTGGTGATCCTGGTTACCCTGGTGAACCCGGAAGGGATGGTGAAAAGGGCCAAAAAGGTGACACTGGCCCACC TGGACCTCCTGGACTTGTAATTCCTAGACCTGGGACTGGTATAACTATAGGAGAAAAAGGAAACATTGGGTTGCCTGGGTTGCCTGGAGA AAAAGGAGAGCGAGGATTTCCTGGAATACAGGGTCCACCTGGCCTTCCTGGACCTCCAGGTGCAGTAGACATTGTTGCAATCATGATCGG CAATCTGAAAGGCACAAAAATTCTGCAATCTATTCAAAGAGGCATACAAGTGACAATGGTCATAGAAGTAGGGAAAAAACATGGCCCTTG GGTGAATCACTATTCAATTTTTTTCGTTTCTGTGTCCTTTTTTATTATTACGGCGGCAACTGTGGGCTATTTTATCTTTTATTCTGCTCG AAGGCTACGGAATGCAAGAGCTCAAAGCAGGAAGCAGAGGCAATTAAAGGCAGATGCTAAAAAAGCTATTGGAAGGCTTCAACTACGCAC ACTGAAACAAGGAGACAAGGAAATTGGCCCTGATGGAGATAGTTGTGCTGTGTGCATTGAATTGTATAAACCAAATGATTTGGTACGCAT CTTAACGTGCAACCATATTTTCCATAAGACATGTGTTGACCCATGGCTGTTAGAACACAGGACTTGCCCCATGTGCAAATGTGACATACT CAAAGCTTTGGGAATTGAGGTGGATGTTGAAGATGGATCAGTGTCTTTACAAGTCCCTGTATCCAATGAAATATCTAATAGTGCCTCCTC CCATGAAGAGGATAATCGCAGCGAGACCGCATCATCTGGATATGCTTCAGTACAGGGAACAGATGAACCGCCTCTGGAGGAACACGTGCA GTCAACAAATGAAAGTCTACAGCTGGTAAACCATGAAGCAAATTCTGTGGCAGTGGATGTTATTCCTCATGTTGACAACCCAACCTTTGA AGAAGACGAAACTCCTAATCAAGAGACTGCTGTTCGAGAAATTAAATCTTAAAATCTGTGTAAATAGAAAACTTGAACCATTAGTAATAA CAGAACTGCCAATCAGGGCCTAGTTTCTATTAATAAATTGGATAAATTTAATAAAATAAGAGTGATACTGAAAGTGCTCAGATGACTAAT ATTATGCTATAGTTAAATGGCTTAAAATATTTAACCTGTTAACTTTTTTCCACAAACTCATTATAATATTTTTCATAGGCAAGTTTCCTC TCAGTAGTGATAACAACATTTTTAGACATTCAAAACTGTCTTCAAGAAGTCACGTTTTTCATTTATAACAATTTTCTTATAAAAACATGT TGCTTTTAAAATGTGGAGTAGCTGTAATCACTTTATTTTATGATAGTATCTTAATGAAAAATACTACTTCTTTAGCTTGGGCTACATGTG TCAGGGTTTTTCTCCAGGTGCTTATATTGATCTGGAATTGTAATGTAAAAAGCAATGCAAACTTAGGCGAGTACTTCTTGAAATGTCTAT TTAAGCTGCTTTAAGTTAATAGAAAAGATTAAAGCAAAATATTCATTTTTACTTTTTCTTATTTTTAAAATTAGGCTGAATGTACTTCAT GTGATTTGTCAACCATAGTTTATCAGAGATTATGGACTTAATTGATTGGTATATTAGTGACATCAACTTGACACAAGATTAGACAAAAAA TTCCTTACAAAAATACTGTGTAACTATTTCTCAAACTTGTGGGATTTTTCAAAAGCTCAGTATATGAATCATCATACTGTTTGAAATTGC TAATGACAGAGTAAGTAACACTAATATTGGTCATTGATCTTCGTTCATGAATTAGTCTACAGAAAAAAAATGTTCTGTAAAATTAGTCTG TTGAAAATGTTTTCCAAACAATGTTACTTTGAAAATTGAGTTTATGTTTGACCTAAATGGGCTAAAATTACATTAGATAAACTAAAATTC TGTCCGTGTAACTATAAATTTTGTGAATGCATTTTCCTGGTGTTTGAAAAAGAAGGGGGGGAGAATTCCAGGTGCCTTAATATAAAGTTT GAAGCTTCATCCACCAAAGTTAAATAGAGCTATTTAAAAATGCACTTTATTTGTACTCTGTGTGGCTTTTGTTTTAGAATTTTGTTCAAA TTATAGCAGAATTTAGGCAAAAATAAAACAGACATGTATTTTTGTTTGCTGAATGGATGAAACCATTGCATTCTTGTACACTGATTTGAA >In-frame_ENST00000361603_ENST00000255499_TCGA-77-A5GH-01A_COL4A5_chrX_107829977_-_RNF128_chrX_106016143_length(amino acids)=655AA_start in transcript=244_stop in transcript=2211 MKLRGVSLAAGLFLLALSLWGQPAEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHPGLPGFPGPEGPPGPRGQKGDDGIPGPPGPKG IRGPPGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYPGPPG IQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPG PPGIRGPPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRDGEKGQKGDTGPPGPPGLVIPRPGTGITIGEKGN IGLPGLPGEKGERGFPGIQGPPGLPGPPGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATV GYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRT CPMCKCDILKALGIEVDVEDGSVSLQVPVSNEISNSASSHEEDNRSETASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEANSVAVDVI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for COL4A5-RNF128 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for COL4A5-RNF128 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for COL4A5-RNF128 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | COL4A5 | C4746986 | ALPORT SYNDROME 1, X-LINKED | 24 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | COL4A5 | C1567741 | Alport Syndrome | 12 | CLINGEN;GENOMICS_ENGLAND |
| Hgene | COL4A5 | C0017668 | Focal glomerulosclerosis | 1 | GENOMICS_ENGLAND |
| Hgene | COL4A5 | C0018965 | Hematuria | 1 | GENOMICS_ENGLAND |
| Hgene | COL4A5 | C0033687 | Proteinuria | 1 | GENOMICS_ENGLAND |
| Hgene | COL4A5 | C0086533 | Leiomyoma, Epithelioid | 1 | CTD_human |
| Hgene | COL4A5 | C0241908 | Hematuria, Benign Familial | 1 | GENOMICS_ENGLAND |
| Hgene | COL4A5 | C1384666 | hearing impairment | 1 | GENOMICS_ENGLAND |
| Hgene | COL4A5 | C1567742 | Alport Syndrome, X-Linked | 1 | GENOMICS_ENGLAND |
| Hgene | COL4A5 | C1567743 | Alport Syndrome, Autosomal Dominant | 1 | GENOMICS_ENGLAND |
| Hgene | COL4A5 | C1567744 | Alport Syndrome, Autosomal Recessive | 1 | GENOMICS_ENGLAND |
| Hgene | COL4A5 | C1839884 | Leiomyomatosis, esophageal and vulval, with nephropathy | 1 | ORPHANET |
| Hgene | COL4A5 | C4049702 | Focal Segmental Glomerulosclerosis, Not Otherwise Specified | 1 | GENOMICS_ENGLAND |
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