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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CP-COMMD2 (FusionGDB2 ID:18894)

Fusion Gene Summary for CP-COMMD2

Fusion gene summary

Fusion gene information	Fusion gene name: CP-COMMD2
	Fusion gene ID: 18894
		Hgene	Tgene
	Gene symbol	CP	COMMD2
	Gene ID	1356	51122
	Gene name	ceruloplasmin	COMM domain containing 2
	Synonyms	CP-2	HSPC042
	Cytomap	3q24-q25.1	3q25.1
	Type of gene	protein-coding	protein-coding
	Description	ceruloplasminceruloplasmin (ferroxidase)	COMM domain-containing protein 2
	Modification date	20200320	20200313
	UniProtAcc	.	Q86X83
	Ensembl transtripts involved in fusion gene	ENST00000264613, ENST00000462336,	ENST00000473414,
Fusion gene scores	* DoF score	6 X 5 X 5=150	4 X 3 X 3=36
	# samples	7	4
	** MAII score	log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CP [Title/Abstract] AND COMMD2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CP(148895627)-COMMD2(149459505), # samples:2
Anticipated loss of major functional domain due to fusion event.	CP-COMMD2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across COMMD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4GH-01A	CP	chr3	148895627	-	COMMD2	chr3	149459505	-
ChimerDB4	STAD	TCGA-HU-A4GH-01A	CP	chr3	148895627	-	COMMD2	chr3	149459505	-
ChimerDB4	STAD	TCGA-HU-A4GH-01A	CP	chr3	148894037	-	COMMD2	chr3	149459505	-

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Fusion Gene ORF analysis for CP-COMMD2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000264613	ENST00000473414	CP	chr3	148895627	-	COMMD2	chr3	149459505	-
intron-3CDS	ENST00000462336	ENST00000473414	CP	chr3	148895627	-	COMMD2	chr3	149459505	-
In-frame	ENST00000264613	ENST00000473414	CP	chr3	148894037	-	COMMD2	chr3	149459505	-
intron-3CDS	ENST00000462336	ENST00000473414	CP	chr3	148894037	-	COMMD2	chr3	149459505	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000264613

chr3

148894037

ENST00000473414

COMMD2

chr3

149459505

6693

3444

212

3454

1080

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264613	ENST00000473414	CP	chr3	148894037	-	COMMD2	chr3	149459505	-	9.83E-05	0.99990165

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Fusion Genomic Features for CP-COMMD2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CP-COMMD2

Go to
FGviewer for the breakpoints of chr3:148894037-chr3:149459505
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	COMMD2 Q86X83
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). {ECO:0000269\|PubMed:15799966, ECO:0000305\|PubMed:21778237}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

chr3:148894037

chr3:149459505

ENST00000264613

209_357

1060.3333333333333

1066.0

Domain

Note=Plastocyanin-like 2

Hgene

chr3:148894037

chr3:149459505

ENST00000264613

20_200

1060.3333333333333

1066.0

Domain

Note=Plastocyanin-like 1

Hgene

chr3:148894037

chr3:149459505

ENST00000264613

20_357

1060.3333333333333

1066.0

Domain

Note=F5/8 type A 1

Hgene

chr3:148894037

chr3:149459505

ENST00000264613

370_560

1060.3333333333333

1066.0

Domain

Note=Plastocyanin-like 3

Hgene

chr3:148894037

chr3:149459505

ENST00000264613

370_718

1060.3333333333333

1066.0

Domain

Note=F5/8 type A 2

Hgene

chr3:148894037

chr3:149459505

ENST00000264613

570_718

1060.3333333333333

1066.0

Domain

Note=Plastocyanin-like 4

Hgene

chr3:148894037

chr3:149459505

ENST00000264613

730_1061

1060.3333333333333

1066.0

Domain

Note=F5/8 type A 3

Hgene

chr3:148894037

chr3:149459505

ENST00000264613

730_900

1060.3333333333333

1066.0

Domain

Note=Plastocyanin-like 5

Hgene

chr3:148894037

chr3:149459505

ENST00000264613

908_1061

1060.3333333333333

1066.0

Domain

Note=Plastocyanin-like 6

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

COMMD2

chr3:148894037

chr3:149459505

ENST00000473414

123_190

134.0

200.0

Domain

COMM

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Fusion Gene Sequence for CP-COMMD2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000264613_ENST00000473414_TCGA-HU-A4GH-01A_CP_chr3_148894037_-_COMMD2_chr3_149459505_length(transcript)=6693nt_BP=3444nt
AGAGTTATGCACACCCTAATGCCTCCAACAATAACTGTTGACTTTTTATTTTCAGTCAGAGAAGCCTGGCAACCAAGAACTGTTTTTTTG
GTGGTTTACGAGAACTTAACTGAATTGGAAAATATTTGCTTTAATGAAACAATTTACTCTTGTGCAACACTAAATTGTGTCAATCAAGCA
AATAAGGAAGAAAGTCTTATTTATAAAATTGCCTGCTCCTGATTTTACTTCATTTCTTCTCAGGCTCCAAGAAGGGGAAAAAAATGAAGA
TTTTGATACTTGGTATTTTTCTGTTTTTATGTAGTACCCCAGCCTGGGCGAAAGAAAAGCATTATTACATTGGAATTATTGAAACGACTT
GGGATTATGCCTCTGACCATGGGGAAAAGAAACTTATTTCTGTTGACACGGAACATTCCAATATCTATCTTCAAAATGGCCCAGATAGAA
TTGGGAGACTATATAAGAAGGCCCTTTATCTTCAGTACACAGATGAAACCTTTAGGACAACTATAGAAAAACCGGTCTGGCTTGGGTTTT
TAGGCCCTATTATCAAAGCTGAAACTGGAGATAAAGTTTATGTACACTTAAAAAACCTTGCCTCTAGGCCCTACACCTTTCATTCACATG
GAATAACTTACTATAAGGAACATGAGGGGGCCATCTACCCTGATAACACCACAGATTTTCAAAGAGCAGATGACAAAGTATATCCAGGAG
AGCAGTATACATACATGTTGCTTGCCACTGAAGAACAAAGTCCTGGGGAAGGAGATGGCAATTGTGTGACTAGGATTTACCATTCCCACA
TTGATGCTCCAAAAGATATTGCCTCAGGACTCATCGGACCTTTAATAATCTGTAAAAAAGATTCTCTAGATAAAGAAAAAGAAAAACATA
TTGACCGAGAATTTGTGGTGATGTTTTCTGTGGTGGATGAAAATTTCAGCTGGTACCTAGAAGACAACATTAAAACCTACTGCTCAGAAC
CAGAGAAAGTTGACAAAGACAACGAAGACTTCCAGGAGAGTAACAGAATGTATTCTGTGAATGGATACACTTTTGGAAGTCTCCCAGGAC
TCTCCATGTGTGCTGAAGACAGAGTAAAATGGTACCTTTTTGGTATGGGTAATGAAGTTGATGTGCACGCAGCTTTCTTTCACGGGCAAG
CACTGACTAACAAGAACTACCGTATTGACACAATCAACCTCTTTCCTGCTACCCTGTTTGATGCTTATATGGTGGCCCAGAACCCTGGAG
AATGGATGCTCAGCTGTCAGAATCTAAACCATCTGAAAGCCGGTTTGCAAGCCTTTTTCCAGGTCCAGGAGTGTAACAAGTCTTCATCAA
AGGATAATATCCGTGGGAAGCATGTTAGACACTACTACATTGCCGCTGAGGAAATCATCTGGAACTATGCTCCCTCTGGTATAGACATCT
TCACTAAAGAAAACTTAACAGCACCTGGAAGTGACTCAGCGGTGTTTTTTGAACAAGGTACCACAAGAATTGGAGGCTCTTATAAAAAGC
TGGTTTATCGTGAGTACACAGATGCCTCCTTCACAAATCGAAAGGAGAGAGGCCCTGAAGAAGAGCATCTTGGCATCCTGGGTCCTGTCA
TTTGGGCAGAGGTGGGAGACACCATCAGAGTAACCTTCCATAACAAAGGAGCATATCCCCTCAGTATTGAGCCGATTGGGGTGAGATTCA
ATAAGAACAACGAGGGCACATACTATTCCCCAAATTACAACCCCCAGAGCAGAAGTGTGCCTCCTTCAGCCTCCCATGTGGCACCCACAG
AAACATTCACCTATGAATGGACTGTCCCCAAAGAAGTAGGACCCACTAATGCAGATCCTGTGTGTCTAGCTAAGATGTATTATTCTGCTG
TGGAACCCACTAAAGATATATTCACTGGGCTTATTGGGCCAATGAAAATATGCAAGAAAGGAAGTTTACATGCAAATGGGAGACAGAAAG
ATGTAGACAAGGAATTCTATTTGTTTCCTACAGTATTTGATGAGAATGAGAGTTTACTCCTGGAAGATAATATTAGAATGTTTACAACTG
CACCTGATCAGGTGGATAAGGAAGATGAAGACTTTCAGGAATCTAATAAAATGCACTCCATGAATGGATTCATGTATGGGAATCAGCCGG
GTCTCACTATGTGCAAAGGAGATTCGGTCGTGTGGTACTTATTCAGCGCCGGAAATGAGGCCGATGTACATGGAATATACTTTTCAGGAA
ACACATATCTGTGGAGAGGAGAACGGAGAGACACAGCAAACCTCTTCCCTCAAACAAGTCTTACGCTCCACATGTGGCCTGACACAGAGG
GGACTTTTAATGTTGAATGCCTTACAACTGATCATTACACAGGCGGCATGAAGCAAAAATATACTGTGAACCAATGCAGGCGGCAGTCTG
AGGATTCCACCTTCTACCTGGGAGAGAGGACATACTATATCGCAGCAGTGGAGGTGGAATGGGATTATTCCCCACAAAGGGAGTGGGAAA
AGGAGCTGCATCATTTACAAGAGCAGAATGTTTCAAATGCATTTTTAGATAAGGGAGAGTTTTACATAGGCTCAAAGTACAAGAAAGTTG
TGTATCGGCAGTATACTGATAGCACATTCCGTGTTCCAGTGGAGAGAAAAGCTGAAGAAGAACATCTGGGAATTCTAGGTCCACAACTTC
ATGCAGATGTTGGAGACAAAGTCAAAATTATCTTTAAAAACATGGCCACAAGGCCCTACTCAATACATGCCCATGGGGTACAAACAGAGA
GTTCTACAGTTACTCCAACATTACCAGGTGAAACTCTCACTTACGTATGGAAAATCCCAGAAAGATCTGGAGCTGGAACAGAGGATTCTG
CTTGTATTCCATGGGCTTATTATTCAACTGTGGATCAAGTTAAGGACCTCTACAGTGGATTAATTGGCCCCCTGATTGTTTGTCGAAGAC
CTTACTTGAAAGTATTCAATCCCAGAAGGAAACTGGAATTTGCCCTTCTGTTTCTAGTTTTTGATGAGAATGAATCTTGGTACTTAGATG
ACAACATCAAAACATACTCTGATCACCCCGAGAAAGTAAACAAAGATGATGAGGAATTCATAGAAAGCAATAAAATGCATGCTATTAATG
GAAGAATGTTTGGAAACCTACAAGGCCTCACAATGCACGTGGGAGATGAAGTCAACTGGTATCTGATGGGAATGGGCAATGAAATAGACT
TACACACTGTACATTTTCACGGCCATAGCTTCCAATACAAGCACAGGGGAGTTTATAGTTCTGATGTCTTTGACATTTTCCCTGGAACAT
ACCAAACCCTAGAAATGTTTCCAAGAACACCTGGAATTTGGTTACTCCACTGCCATGTGACCGACCACATTCATGCTGGAATGGAAACCA
CTTACACCGTTCTACAAAATGAAGCTTGCAAGTAGAAGTCTCAGGCAACAGATTAAACCAGCAGTGACTATAAAGCTACACCTTAATCAA
AATGGAGATCACAACACCAAAGTTCTGCAGACAGACCCAGCCACCCTGCTCCATTTGGTTCAACAACTGGAACAAGCATTGGAAGAGATG
AAGACAAATCACTGTAGGAGAGTTGTTCGCAACATCAAGTAGTACCAGTTTTAAGGTTTTAATTCATTTGAATCACTTATGAATTGATGA
TATACAGCAATTACTTTTCAAAATTAATTTTTTATTAATTCATGATGATAAATACATAGTATTCCTCAGTATCTATTCCAAGATACTGAG
GTCATAATCAGAAGCTAAGCTGGGTGCAGTGGCTCATGCCAGTTATCCCAGCACTTTGGGAGGCCGAGGTGGGCAAATCATGAGGTCAGG
AGATTGAGACCTTCCTGGCTAACATGGTGAAACCCCATCTCTACTAAAAATATAAAAAATTAGCCAGGTGTGGTGGCACGCATCTATCAG
AGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTC
CAGCCTGGGTGACAGAGTGAGACTCCATCTCAAAAATAATAATAATAATAATAAAGTAAAAATAAAAATAAAAAAGTAATCAGAAGCTAA
AGTAAAGTTCCTTTCCTGGTGCTAACTGTGGTCTTCTTGACACATTAAGATGTATTTTGTATTTTAAGAGTCTCATGCTCTACCGTTGGA
ACTAGCCAGATGGCCATTATTTTGTATTTTAAATACATAAATAGGATTGAATCAACTAGAAATGAATCTATATGTTCTGTATATATGAAT
GACTATCTTGTTTTTGCTACTTCTTTTGACTGCTTAATTTTATTATTTTCATCTTTATTGATCAAATTTGAAAATAAAATTCACAATGTA
ATACTACTACTATGCAGAATTTTCTAAACAGTTCAGTATTTTTGACTTTTAAAAACACCCCACAGTGTTAATAGCCACAGAATATTGAAC
ATCAATAGGATTTTTAATGCTATATTGTTATAGGCAGTTTATTCATTTTTCTTTGTATATGAAGATGATAAGTATCATATTGCCTAAGTT
TGAGTGATCATGGTTAATTAATTGGCTTAAATAGTACTCAAATTTGTGTGGTCGTATATTGTATTTTATCAAGGACTAATTCTTCCACCA
TACCCAAAGCATCTAGGAGACACTCTGTCATTTACATTTACAAATAATGGATGCAGAGAAATATAATCAATTCTTGATTGTCCTGGATAC
AAATTATAGTCACTTTTTATAATTTGAATAAACTATGATGAGGGAAGGAAGGCCATGTTTATTACATTATAGGCAACTATCCCTTCTCAA
AACATAACTTGATTTATGTTTTGTTTTATTTTTTAGTAGGGAACCAAAAGCTTTTGGTCTGAAAAACTCAGGTGCTGATTTGTCAGGTCA
GCCTGAGAGAGTGCAGAGATACTGAGGTCAGCTTAGGGAGAAGAATTGTATGGAAGGGTGGAAATGAGGGTTCAGTCTTAACTATGTGTC
CAAGACCTTATCCTGAGAGTCTTCATGGAATAATCTAGAAAGGGCTGTAGAAGCAATCAAACTCTAAACTGCGCTCTAGACTTTGTCAAT
ACTTTGCTTCGTAAGAATTAGGGATTTTCATATCAGAGTGATACCATGTTGCAATCTCTTTAGAGAAGAGAGAGCCTAGCAGGGAATAGG
CTAGTGGAAGAAAAACATACTTGAGATGGTTACCCATTGGTCCCTGCAGGCATCTGGGCCACCCTTTTCCTGTAGGTATATATTCTGCCG
TTGTGAAACAACTATATTATTAGATGTCAGCAAACTATAATCAGAAATAATTTTTAATTATAGTGGCAACTTGATTAATGAAGCTCTCAT
ATACAACCTCACAAACAAAAAGAAACTTTATTACGTGAAATAGTAGCATATGTCATTGGGTTTAAAAGCAACATGCCTGCAAAACATATG
ATAAAAAATACCTCTGTAAGGGTTTTTATTTGTCCACCTTCGATGGAAGGTAAACATGGCTGATCCCAGCCAAGATGAAACAATAGCCCT
TTGTCTCCTCAGAACAACCTATCTCCAACTCTTTGTCCACTGTTCTTACCCCAATTAAAACAAGAAAGCATGTGCTAATCCTTTTTTAAT
TTTTATCAACCTGCCTTGGCCTCCTTTCACTGTACTCCATTATTCCTTCTGTGATGTTCTACCTTCTTCACCTTTTGAGACCAGGGTGAG
TTGGGAGCAGTTTGCCTACCTTCTTTTAGAATCTGGGGCTTATCTTTTAGTACAAGCCATTGAATAAGCCTCTTCCTTTTTTTTGCTCAA
ACATTCCACATCCTTGTGGATTCCCCTGCATTGTTTGTTTTATATAACATTTGATATTTGTTGTAGCTTGTATATGAACATAATTTTCTT
TAGAGGTAGTCACTGTTCTCTCCAGTATGACCCAGGTTTCTTGACTCTGAGTAATGCACCTTCTATAACTATCTAAATTTCTATTGAAGC
TTTTTGGATTATGAGTATGCTGACTTTTCACGATTGGCTGGTGCATGTTTAGACTTAAATGTCATATCCTTCATGTCTCAAAGCCAAAAT
AGTAACATCTCATCTCAGAACAGAGCTGTGACCACATGCCAATATATGTGTCACAAAGTCTACATATGTTACATTCCTTGGAAGTCTCCT
TAAATGTTTCACAAAATGTCAACAAGCTTGTTTTGTTATTGATATTTCCGAGATTGGGCACATTTAAGACAGTAAACGGGAAAGGTGGTG
AAGATGCTATAAGAAGATGCTGTATCTTGAGAATTGAAAAATGAGAATCTGACATGGTTTGAAAAATCATGAAGGGTATATATAAAGGAT
GCATGTGTAGGAGCCATTAAAATTCATAACAGTATGTGCCCCTTCAGCGTTTTAATCTTATGAAGTGGTTAAGAGATAAGTCTTCGGAGT
TGGACAAAAGGATTTGAATTTAGGTTCTGTGGATTATTATGGGTCCTTGATAAATTCTCAAAGCCTTTTTTTTTGTTCATCTCTAAAATA
GGAATATAGGATTACCTACCACATTGACTCGTAAGGACTATATGAGACCATGTATATAGAATGTTTAACATAGTACCAGGCTTTACAAAG

>In-frame_ENST00000264613_ENST00000473414_TCGA-HU-A4GH-01A_CP_chr3_148894037_-_COMMD2_chr3_149459505_length(amino acids)=1080AA_start in transcript=212_stop in transcript=3454
MLLILLHFFSGSKKGKKMKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYL
QYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATE
EQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDF
QESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNH
LKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASF
TNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPK
EVGPTNADPVCLAKMYYSAVEPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDED
FQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTD
HYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFR
VPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTV
DQVKDLYSGLIGPLIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLT
MHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEACK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CP-COMMD2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CP-COMMD2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CP-COMMD2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CP	C0878682	Ceruloplasmin deficiency	6	CTD_human;GENOMICS_ENGLAND
Hgene	CP	C0019202	Hepatolenticular Degeneration	3	CTD_human
Hgene	CP	C1527352	Hepatic Form of Wilson Disease	3	CTD_human
Hgene	CP	C2931082	Familial apoceruloplasmin deficiency	3	CTD_human
Hgene	CP	C0022116	Ischemia	2	CTD_human
Hgene	CP	C0023890	Liver Cirrhosis	2	CTD_human
Hgene	CP	C0030567	Parkinson Disease	2	CTD_human
Hgene	CP	C0239946	Fibrosis, Liver	2	CTD_human
Hgene	CP	C0001925	Albuminuria	1	CTD_human
Hgene	CP	C0003865	Arthritis, Adjuvant-Induced	1	CTD_human
Hgene	CP	C0003873	Rheumatoid Arthritis	1	CTD_human
Hgene	CP	C0004134	Ataxia	1	CTD_human
Hgene	CP	C0004352	Autistic Disorder	1	CTD_human
Hgene	CP	C0006111	Brain Diseases	1	CTD_human
Hgene	CP	C0007102	Malignant tumor of colon	1	CTD_human
Hgene	CP	C0009375	Colonic Neoplasms	1	CTD_human
Hgene	CP	C0011849	Diabetes Mellitus	1	CTD_human
Hgene	CP	C0011854	Diabetes Mellitus, Insulin-Dependent	1	CTD_human
Hgene	CP	C0012715	Iron Metabolism Disorders	1	CTD_human
Hgene	CP	C0013221	Drug toxicity	1	CTD_human
Hgene	CP	C0013384	Dyskinetic syndrome	1	CTD_human
Hgene	CP	C0013421	Dystonia	1	GENOMICS_ENGLAND
Hgene	CP	C0018995	Hemochromatosis	1	CTD_human
Hgene	CP	C0019189	Hepatitis, Chronic	1	CTD_human
Hgene	CP	C0019193	Hepatitis, Toxic	1	CTD_human
Hgene	CP	C0019207	Hepatoma, Morris	1	CTD_human
Hgene	CP	C0019208	Hepatoma, Novikoff	1	CTD_human
Hgene	CP	C0022660	Kidney Failure, Acute	1	CTD_human
Hgene	CP	C0022716	Menkes Kinky Hair Syndrome	1	CTD_human
Hgene	CP	C0023904	Liver Neoplasms, Experimental	1	CTD_human
Hgene	CP	C0025202	melanoma	1	CTD_human
Hgene	CP	C0027746	Nerve Degeneration	1	CTD_human
Hgene	CP	C0030246	Pustulosis of Palms and Soles	1	CTD_human
Hgene	CP	C0032914	Pre-Eclampsia	1	CTD_human
Hgene	CP	C0033860	Psoriasis	1	CTD_human
Hgene	CP	C0035304	Retinal Degeneration	1	CTD_human
Hgene	CP	C0036341	Schizophrenia	1	CTD_human
Hgene	CP	C0041755	Adverse reaction to drug	1	CTD_human
Hgene	CP	C0085397	Pasteurellaceae Infections	1	CTD_human
Hgene	CP	C0085584	Encephalopathies	1	CTD_human
Hgene	CP	C0086404	Experimental Hepatoma	1	CTD_human
Hgene	CP	C0149519	Chronic Persistent Hepatitis	1	CTD_human
Hgene	CP	C0152115	Lingual-Facial-Buccal Dyskinesia	1	CTD_human
Hgene	CP	C0205734	Diabetes, Autoimmune	1	CTD_human
Hgene	CP	C0221169	Hemiballismus	1	CTD_human
Hgene	CP	C0232766	Asterixis	1	CTD_human
Hgene	CP	C0240991	Ataxia, Sensory	1	CTD_human
Hgene	CP	C0278161	Ataxia, Motor	1	CTD_human
Hgene	CP	C0282193	Iron Overload	1	CTD_human
Hgene	CP	C0338630	Senile Paranoid Dementia	1	CTD_human
Hgene	CP	C0342302	Brittle diabetes	1	CTD_human
Hgene	CP	C0392514	Hereditary hemochromatosis	1	CTD_human
Hgene	CP	C0427086	Involuntary Movements	1	CTD_human
Hgene	CP	C0427190	Ataxia, Truncal	1	CTD_human
Hgene	CP	C0454606	Oral Dyskinesia	1	CTD_human
Hgene	CP	C0497327	Dementia	1	CTD_human
Hgene	CP	C0520463	Chronic active hepatitis	1	CTD_human
Hgene	CP	C0520966	Abnormal coordination	1	CTD_human
Hgene	CP	C0524611	Cryptogenic Chronic Hepatitis	1	CTD_human
Hgene	CP	C0750937	Ataxia, Appendicular	1	CTD_human
Hgene	CP	C0750940	Tremor, Rubral	1	CTD_human
Hgene	CP	C0751071	Familial Dementia	1	CTD_human
Hgene	CP	C0752196	Ballismus	1	CTD_human
Hgene	CP	C0860207	Drug-Induced Liver Disease	1	CTD_human
Hgene	CP	C0971858	Arthritis, Collagen-Induced	1	CTD_human
Hgene	CP	C0993582	Arthritis, Experimental	1	CTD_human
Hgene	CP	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Hgene	CP	C1565662	Acute Kidney Insufficiency	1	CTD_human
Hgene	CP	C2239176	Liver carcinoma	1	CTD_human
Hgene	CP	C2609414	Acute kidney injury	1	CTD_human
Hgene	CP	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Hgene	CP	C3837958	Diabetes Mellitus, Ketosis-Prone	1	CTD_human
Hgene	CP	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Hgene	CP	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
Hgene	CP	C4554117	Diabetes Mellitus, Sudden-Onset	1	CTD_human