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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CPD-AATF (FusionGDB2 ID:18934)

Fusion Gene Summary for CPD-AATF

check button Fusion gene summary
Fusion gene informationFusion gene name: CPD-AATF
Fusion gene ID: 18934
HgeneTgene
Gene symbol

CPD

AATF

Gene ID

9455

26574

Gene namehomer scaffold protein 2apoptosis antagonizing transcription factor
SynonymsACPD|CPD|DFNA68|HOMER-2|VESL-2BFR2|CHE-1|CHE1|DED
Cytomap

15q25.2

17q12

Type of geneprotein-codingprotein-coding
Descriptionhomer protein homolog 2cupidinhomer homolog 2homer homolog 3homer scaffolding protein 2homer, neuronal immediate early gene, 2protein AATFrb-binding protein Che-1
Modification date2020031320200313
UniProtAcc.

Q9NY61

Ensembl transtripts involved in fusion geneENST00000225719, ENST00000543464, 
ENST00000584051, 		ENST00000225402, 
ENST00000590321, 
Fusion gene scores* DoF score26 X 16 X 10=416026 X 13 X 11=3718
# samples 2628
** MAII scorelog2(26/4160*10)=-4
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/3718*10)=-3.73102803797452
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CPD [Title/Abstract] AND AATF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCPD(28748001)-AATF(35376304), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAATF

GO:0032929

negative regulation of superoxide anion generation

15207272

TgeneAATF

GO:0045944

positive regulation of transcription by RNA polymerase II

18049476

TgeneAATF

GO:2000378

negative regulation of reactive oxygen species metabolic process

15207272


check buttonFusion gene breakpoints across CPD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across AATF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A1FW-01ACPDchr17

28748001

+AATFchr17

35376304

+
ChimerDB4BRCATCGA-A2-A1FWCPDchr17

28748001

+AATFchr17

35376303

+
ChimerDB4BRCATCGA-A2-A1FW-01ACPDchr17

28748001

+AATFchr17

35376304

+
ChimerDB4BRCATCGA-A2-A1FW-01ACPDchr17

28748001

-AATFchr17

35376304

+
ChimerDB4BRCATCGA-A2-A1FW-01ACPDchr17

28748000

+AATFchr17

35376303

+


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Fusion Gene ORF analysis for CPD-AATF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000225719ENST00000225402CPDchr17

28748001

+AATFchr17

35376304

+
5CDS-intronENST00000225719ENST00000590321CPDchr17

28748001

+AATFchr17

35376304

+
In-frameENST00000543464ENST00000225402CPDchr17

28748001

+AATFchr17

35376304

+
5CDS-intronENST00000543464ENST00000590321CPDchr17

28748001

+AATFchr17

35376304

+
intron-3CDSENST00000584051ENST00000225402CPDchr17

28748001

+AATFchr17

35376304

+
intron-intronENST00000584051ENST00000590321CPDchr17

28748001

+AATFchr17

35376304

+
In-frameENST00000225719ENST00000225402CPDchr17

28748001

+AATFchr17

35376303

+
5CDS-intronENST00000225719ENST00000590321CPDchr17

28748001

+AATFchr17

35376303

+
In-frameENST00000543464ENST00000225402CPDchr17

28748001

+AATFchr17

35376303

+
5CDS-intronENST00000543464ENST00000590321CPDchr17

28748001

+AATFchr17

35376303

+
intron-3CDSENST00000584051ENST00000225402CPDchr17

28748001

+AATFchr17

35376303

+
intron-intronENST00000584051ENST00000590321CPDchr17

28748001

+AATFchr17

35376303

+
In-frameENST00000225719ENST00000225402CPDchr17

28748000

+AATFchr17

35376303

+
5CDS-intronENST00000225719ENST00000590321CPDchr17

28748000

+AATFchr17

35376303

+
In-frameENST00000543464ENST00000225402CPDchr17

28748000

+AATFchr17

35376303

+
5CDS-intronENST00000543464ENST00000590321CPDchr17

28748000

+AATFchr17

35376303

+
intron-3CDSENST00000584051ENST00000225402CPDchr17

28748000

+AATFchr17

35376303

+
intron-intronENST00000584051ENST00000590321CPDchr17

28748000

+AATFchr17

35376303

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000225719CPDchr1728748001+ENST00000225402AATFchr1735376304+17051213761497473
ENST00000543464CPDchr1728748001+ENST00000225402AATFchr1735376304+12907984021082226
ENST00000225719CPDchr1728748001+ENST00000225402AATFchr1735376303+17051213761497473
ENST00000543464CPDchr1728748001+ENST00000225402AATFchr1735376303+12907984021082226
ENST00000225719CPDchr1728748000+ENST00000225402AATFchr1735376303+17051213761497473
ENST00000543464CPDchr1728748000+ENST00000225402AATFchr1735376303+12907984021082226

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000225719ENST00000225402CPDchr1728748001+AATFchr1735376304+0.0071604960.99283946
ENST00000543464ENST00000225402CPDchr1728748001+AATFchr1735376304+0.0013606430.9986394
ENST00000225719ENST00000225402CPDchr1728748001+AATFchr1735376303+0.0071604960.99283946
ENST00000543464ENST00000225402CPDchr1728748001+AATFchr1735376303+0.0013606430.9986394
ENST00000225719ENST00000225402CPDchr1728748000+AATFchr1735376303+0.0071604960.99283946
ENST00000543464ENST00000225402CPDchr1728748000+AATFchr1735376303+0.0013606430.9986394

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Fusion Genomic Features for CPD-AATF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CPDchr1728748001+AATFchr1735376303+7.96E-080.9999999
CPDchr1728748001+AATFchr1735376303+7.96E-080.9999999
CPDchr1728748001+AATFchr1735376303+7.96E-080.9999999
CPDchr1728748001+AATFchr1735376303+7.96E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CPD-AATF


check button Go to

FGviewer for the breakpoints of chr17:28748001-chr17:35376304

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AATF

Q9NY61

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. {ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090, ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPDchr17:28748000chr17:35376303ENST00000225719+321162_164379.01381.0MotifCell attachment site
HgeneCPDchr17:28748001chr17:35376303ENST00000225719+321162_164379.01381.0MotifCell attachment site
HgeneCPDchr17:28748001chr17:35376304ENST00000225719+321162_164379.01381.0MotifCell attachment site

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPDchr17:28748000chr17:35376303ENST00000543464+321162_164132.01134.0MotifCell attachment site
HgeneCPDchr17:28748001chr17:35376303ENST00000543464+321162_164132.01134.0MotifCell attachment site
HgeneCPDchr17:28748001chr17:35376304ENST00000543464+321162_164132.01134.0MotifCell attachment site
HgeneCPDchr17:28748000chr17:35376303ENST00000225719+32132_493379.01381.0RegionNote=Carboxypeptidase-like 1
HgeneCPDchr17:28748000chr17:35376303ENST00000225719+321494_897379.01381.0RegionNote=Carboxypeptidase-like 2
HgeneCPDchr17:28748000chr17:35376303ENST00000225719+321898_1299379.01381.0RegionNote=Carboxypeptidase-like 3
HgeneCPDchr17:28748000chr17:35376303ENST00000543464+32132_493132.01134.0RegionNote=Carboxypeptidase-like 1
HgeneCPDchr17:28748000chr17:35376303ENST00000543464+321494_897132.01134.0RegionNote=Carboxypeptidase-like 2
HgeneCPDchr17:28748000chr17:35376303ENST00000543464+321898_1299132.01134.0RegionNote=Carboxypeptidase-like 3
HgeneCPDchr17:28748001chr17:35376303ENST00000225719+32132_493379.01381.0RegionNote=Carboxypeptidase-like 1
HgeneCPDchr17:28748001chr17:35376303ENST00000225719+321494_897379.01381.0RegionNote=Carboxypeptidase-like 2
HgeneCPDchr17:28748001chr17:35376303ENST00000225719+321898_1299379.01381.0RegionNote=Carboxypeptidase-like 3
HgeneCPDchr17:28748001chr17:35376303ENST00000543464+32132_493132.01134.0RegionNote=Carboxypeptidase-like 1
HgeneCPDchr17:28748001chr17:35376303ENST00000543464+321494_897132.01134.0RegionNote=Carboxypeptidase-like 2
HgeneCPDchr17:28748001chr17:35376303ENST00000543464+321898_1299132.01134.0RegionNote=Carboxypeptidase-like 3
HgeneCPDchr17:28748001chr17:35376304ENST00000225719+32132_493379.01381.0RegionNote=Carboxypeptidase-like 1
HgeneCPDchr17:28748001chr17:35376304ENST00000225719+321494_897379.01381.0RegionNote=Carboxypeptidase-like 2
HgeneCPDchr17:28748001chr17:35376304ENST00000225719+321898_1299379.01381.0RegionNote=Carboxypeptidase-like 3
HgeneCPDchr17:28748001chr17:35376304ENST00000543464+32132_493132.01134.0RegionNote=Carboxypeptidase-like 1
HgeneCPDchr17:28748001chr17:35376304ENST00000543464+321494_897132.01134.0RegionNote=Carboxypeptidase-like 2
HgeneCPDchr17:28748001chr17:35376304ENST00000543464+321898_1299132.01134.0RegionNote=Carboxypeptidase-like 3
HgeneCPDchr17:28748000chr17:35376303ENST00000225719+3211321_1380379.01381.0Topological domainCytoplasmic
HgeneCPDchr17:28748000chr17:35376303ENST00000225719+32132_1299379.01381.0Topological domainExtracellular
HgeneCPDchr17:28748000chr17:35376303ENST00000543464+3211321_1380132.01134.0Topological domainCytoplasmic
HgeneCPDchr17:28748000chr17:35376303ENST00000543464+32132_1299132.01134.0Topological domainExtracellular
HgeneCPDchr17:28748001chr17:35376303ENST00000225719+3211321_1380379.01381.0Topological domainCytoplasmic
HgeneCPDchr17:28748001chr17:35376303ENST00000225719+32132_1299379.01381.0Topological domainExtracellular
HgeneCPDchr17:28748001chr17:35376303ENST00000543464+3211321_1380132.01134.0Topological domainCytoplasmic
HgeneCPDchr17:28748001chr17:35376303ENST00000543464+32132_1299132.01134.0Topological domainExtracellular
HgeneCPDchr17:28748001chr17:35376304ENST00000225719+3211321_1380379.01381.0Topological domainCytoplasmic
HgeneCPDchr17:28748001chr17:35376304ENST00000225719+32132_1299379.01381.0Topological domainExtracellular
HgeneCPDchr17:28748001chr17:35376304ENST00000543464+3211321_1380132.01134.0Topological domainCytoplasmic
HgeneCPDchr17:28748001chr17:35376304ENST00000543464+32132_1299132.01134.0Topological domainExtracellular
HgeneCPDchr17:28748000chr17:35376303ENST00000225719+3211300_1320379.01381.0TransmembraneHelical
HgeneCPDchr17:28748000chr17:35376303ENST00000543464+3211300_1320132.01134.0TransmembraneHelical
HgeneCPDchr17:28748001chr17:35376303ENST00000225719+3211300_1320379.01381.0TransmembraneHelical
HgeneCPDchr17:28748001chr17:35376303ENST00000543464+3211300_1320132.01134.0TransmembraneHelical
HgeneCPDchr17:28748001chr17:35376304ENST00000225719+3211300_1320379.01381.0TransmembraneHelical
HgeneCPDchr17:28748001chr17:35376304ENST00000543464+3211300_1320132.01134.0TransmembraneHelical
TgeneAATFchr17:28748000chr17:35376303ENST0000022540271296_195466.0561.0Compositional biasNote=Glu-rich
TgeneAATFchr17:28748001chr17:35376303ENST0000022540271296_195466.0561.0Compositional biasNote=Glu-rich
TgeneAATFchr17:28748001chr17:35376304ENST0000022540271296_195466.0561.0Compositional biasNote=Glu-rich
TgeneAATFchr17:28748000chr17:35376303ENST00000225402712273_315466.0561.0RegionNote=POLR2J binding
TgeneAATFchr17:28748000chr17:35376303ENST00000225402712316_372466.0561.0RegionNote=RB1 binding
TgeneAATFchr17:28748000chr17:35376303ENST00000225402712373_472466.0561.0RegionNote=RB1 and SP1 binding
TgeneAATFchr17:28748001chr17:35376303ENST00000225402712273_315466.0561.0RegionNote=POLR2J binding
TgeneAATFchr17:28748001chr17:35376303ENST00000225402712316_372466.0561.0RegionNote=RB1 binding
TgeneAATFchr17:28748001chr17:35376303ENST00000225402712373_472466.0561.0RegionNote=RB1 and SP1 binding
TgeneAATFchr17:28748001chr17:35376304ENST00000225402712273_315466.0561.0RegionNote=POLR2J binding
TgeneAATFchr17:28748001chr17:35376304ENST00000225402712316_372466.0561.0RegionNote=RB1 binding
TgeneAATFchr17:28748001chr17:35376304ENST00000225402712373_472466.0561.0RegionNote=RB1 and SP1 binding


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Fusion Gene Sequence for CPD-AATF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000225719_ENST00000225402_TCGA-A2-A1FW-01A_CPD_chr17_28748001_+_AATF_chr17_35376304_length(transcript)=1705nt_BP=1213nt
GGGGATCCGGCGGGCCCCCGCCGCCCGGAGCGCTGAGCCGCGGGAGCGGAGCCGGGGTTAGCGGCGCTGCTGGAAGATGGCGAGCGGCCG
GGACGAGCGGCCGCCTTGGCGGCTAGGGCGGCTCCTGTTGCTCATGTGCCTGCTGCTGCTGGGGAGCTCGGCCCGGGCGGCTCACATCAA
GAAGGCGGAGGCGACTACCACAACTACGAGCGCGGGCGCCGAGGCGGCCGAGGGCCAGTTCGACCGCTACTACCACGAAGAGGAGTTGGA
GTCGGCGCTGAGGGAGGCGGCGGCCGCGGGCCTCCCCGGCCTGGCCCGCCTCTTTAGCATCGGCCGCTCGGTGGAAGGCCGGCCGCTGTG
GGTGCTTCGCCTCACCGCCGGCCTGGGGTCGCTAATCCCTGAGGGCGACGCGGGGCCTGACGCTGCCGGGCCCGACGCTGCGGGGCCGCT
GCTGCCCGGCCGGCCCCAGGTGAAGCTGGTGGGCAACATGCATGGCGACGAGACCGTGTCGCGCCAGGTGTTGATCTACTTGGCCCGCGA
GCTGGCGGCCGGCTACCGCCGCGGGGACCCGCGCCTGGTCCGCCTGCTCAACACCACCGACGTGTACCTGCTGCCCAGCCTCAACCCCGA
TGGCTTCGAGCGTGCCCGCGAGGGCGACTGTGGCTTCGGCGACGGCGGCCCGTCCGGGGCCAGCGGCCGCGACAATAGTCGCGGCCGCGA
CCTCAACCGAAGCTTTCCCGACCAGTTTAGCACCGGCGAACCCCCCGCCCTGGACGAGGTGCCCGAGGTGCGCGCCCTCATCGAGTGGAT
CCGCAGGAACAAGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCAAGCTATCCTTTTGATGATTCTCCAGAACATAAGGC
CACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCCATAATGAAAACTGG
TGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAACGGCGCACATTGGTATGATGTGGAAGGTGGTATGCA
AGATTACAATTATGTGTGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGTTGCAAGTACCCACCTGCTTCACAGCTTCGACAGGA
ATGGGAGAACAATCGTGAGTCTTTGATCACATTGATTGAAAAGCTCCTTCGAGAACTCATAGAACGGAAGACCAGCTCCTTGGATCCCAA
CGATCAGGTGGCCATGGGAAGGCAGTGGCTTGCAATCCAGAAGTTACGAAGCAAAATCCACAAAAAAGTAGATAGGAAAGCCAGCAAAGG
CAGGAAACTTCGGTTTCATGTCCTTAGCAAGCTACTGAGTTTCATGGCACCTATTGACCATACTACAATGAATGATGATGCCAGGACAGA
ACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGACGAAGGCCACGGGGATTGACATCGCCCACCTCCGACACCCAGTGGGCGCCT
TGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGTGACTTTATGGGGCTGAGCTAGTAGGGAAGCCCCTGGAAAGATGCTGCGTTC

>In-frame_ENST00000225719_ENST00000225402_TCGA-A2-A1FW-01A_CPD_chr17_28748001_+_AATF_chr17_35376304_length(amino acids)=473AA_start in transcript=76_stop in transcript=1497
MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVE
GRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLP
SLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDS
PEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPAS
QLRQEWENNRESLITLIEKLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTTMND

--------------------------------------------------------------
>In-frame_ENST00000543464_ENST00000225402_TCGA-A2-A1FW-01A_CPD_chr17_28748001_+_AATF_chr17_35376304_length(transcript)=1290nt_BP=798nt
AGTGTGGCTGGGACTTAGAATTAGGCAATCTGATTCCCGATAGTCCTCTTAGCCACGGAGGGACACTGGAGCCCAAAAATGGCAGATGAT
ATTCCCAGGATCTTCCCCTTGCCTATTTGACAGAAGCTGATTTTTCTCCAATTTTTACCTCTGACTCAGCTTAAGAAGATATGGACTTAG
CTGGAGAACTTGCACAGATCTGTGAGCCGCTTCATTTTAGACTCTGAAGGGTTTGTGATGTCATTTGTGCACCTTATTAGCCTGGGCAGA
ATGGCTAATGGTCACACTTCTAATACACACTTTAAGTGTTATTAAGCATTGCATGAGGTTTAAAAAATTACAAAGTAGAAGAAGGAGGAC
CTCAAGAAATTAGTATAAAACAAGAGAATGTTATAAATATTTATGAGGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCA
AGCTATCCTTTTGATGATTCTCCAGAACATAAGGCCACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAA
GCTTATGCTTCAAACCACCCCATAATGAAAACTGGTGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAAC
GGCGCACATTGGTATGATGTGGAAGGTGGTATGCAAGATTACAATTATGTGTGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGT
TGCAAGTACCCACCTGCTTCACAGCTTCGACAGGAATGGGAGAACAATCGTGAGTCTTTGATCACATTGATTGAAAAGCTCCTTCGAGAA
CTCATAGAACGGAAGACCAGCTCCTTGGATCCCAACGATCAGGTGGCCATGGGAAGGCAGTGGCTTGCAATCCAGAAGTTACGAAGCAAA
ATCCACAAAAAAGTAGATAGGAAAGCCAGCAAAGGCAGGAAACTTCGGTTTCATGTCCTTAGCAAGCTACTGAGTTTCATGGCACCTATT
GACCATACTACAATGAATGATGATGCCAGGACAGAACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGACGAAGGCCACGGGGAT
TGACATCGCCCACCTCCGACACCCAGTGGGCGCCTTGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGTGACTTTATGGGGCTGA
GCTAGTAGGGAAGCCCCTGGAAAGATGCTGCGTTCCGAACCTGTGCCTAATACACGCAAGGGCGCTGTCCCGCCCAACCCCGCCTTTAAA

>In-frame_ENST00000543464_ENST00000225402_TCGA-A2-A1FW-01A_CPD_chr17_28748001_+_AATF_chr17_35376304_length(amino acids)=226AA_start in transcript=402_stop in transcript=1082
MRFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDY
NYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRKASKGRK

--------------------------------------------------------------
>In-frame_ENST00000225719_ENST00000225402_TCGA-A2-A1FW_CPD_chr17_28748001_+_AATF_chr17_35376303_length(transcript)=1705nt_BP=1213nt
GGGGATCCGGCGGGCCCCCGCCGCCCGGAGCGCTGAGCCGCGGGAGCGGAGCCGGGGTTAGCGGCGCTGCTGGAAGATGGCGAGCGGCCG
GGACGAGCGGCCGCCTTGGCGGCTAGGGCGGCTCCTGTTGCTCATGTGCCTGCTGCTGCTGGGGAGCTCGGCCCGGGCGGCTCACATCAA
GAAGGCGGAGGCGACTACCACAACTACGAGCGCGGGCGCCGAGGCGGCCGAGGGCCAGTTCGACCGCTACTACCACGAAGAGGAGTTGGA
GTCGGCGCTGAGGGAGGCGGCGGCCGCGGGCCTCCCCGGCCTGGCCCGCCTCTTTAGCATCGGCCGCTCGGTGGAAGGCCGGCCGCTGTG
GGTGCTTCGCCTCACCGCCGGCCTGGGGTCGCTAATCCCTGAGGGCGACGCGGGGCCTGACGCTGCCGGGCCCGACGCTGCGGGGCCGCT
GCTGCCCGGCCGGCCCCAGGTGAAGCTGGTGGGCAACATGCATGGCGACGAGACCGTGTCGCGCCAGGTGTTGATCTACTTGGCCCGCGA
GCTGGCGGCCGGCTACCGCCGCGGGGACCCGCGCCTGGTCCGCCTGCTCAACACCACCGACGTGTACCTGCTGCCCAGCCTCAACCCCGA
TGGCTTCGAGCGTGCCCGCGAGGGCGACTGTGGCTTCGGCGACGGCGGCCCGTCCGGGGCCAGCGGCCGCGACAATAGTCGCGGCCGCGA
CCTCAACCGAAGCTTTCCCGACCAGTTTAGCACCGGCGAACCCCCCGCCCTGGACGAGGTGCCCGAGGTGCGCGCCCTCATCGAGTGGAT
CCGCAGGAACAAGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCAAGCTATCCTTTTGATGATTCTCCAGAACATAAGGC
CACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCCATAATGAAAACTGG
TGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAACGGCGCACATTGGTATGATGTGGAAGGTGGTATGCA
AGATTACAATTATGTGTGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGTTGCAAGTACCCACCTGCTTCACAGCTTCGACAGGA
ATGGGAGAACAATCGTGAGTCTTTGATCACATTGATTGAAAAGCTCCTTCGAGAACTCATAGAACGGAAGACCAGCTCCTTGGATCCCAA
CGATCAGGTGGCCATGGGAAGGCAGTGGCTTGCAATCCAGAAGTTACGAAGCAAAATCCACAAAAAAGTAGATAGGAAAGCCAGCAAAGG
CAGGAAACTTCGGTTTCATGTCCTTAGCAAGCTACTGAGTTTCATGGCACCTATTGACCATACTACAATGAATGATGATGCCAGGACAGA
ACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGACGAAGGCCACGGGGATTGACATCGCCCACCTCCGACACCCAGTGGGCGCCT
TGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGTGACTTTATGGGGCTGAGCTAGTAGGGAAGCCCCTGGAAAGATGCTGCGTTC

>In-frame_ENST00000225719_ENST00000225402_TCGA-A2-A1FW_CPD_chr17_28748001_+_AATF_chr17_35376303_length(amino acids)=473AA_start in transcript=76_stop in transcript=1497
MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVE
GRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLP
SLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDS
PEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPAS
QLRQEWENNRESLITLIEKLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTTMND

--------------------------------------------------------------
>In-frame_ENST00000543464_ENST00000225402_TCGA-A2-A1FW_CPD_chr17_28748001_+_AATF_chr17_35376303_length(transcript)=1290nt_BP=798nt
AGTGTGGCTGGGACTTAGAATTAGGCAATCTGATTCCCGATAGTCCTCTTAGCCACGGAGGGACACTGGAGCCCAAAAATGGCAGATGAT
ATTCCCAGGATCTTCCCCTTGCCTATTTGACAGAAGCTGATTTTTCTCCAATTTTTACCTCTGACTCAGCTTAAGAAGATATGGACTTAG
CTGGAGAACTTGCACAGATCTGTGAGCCGCTTCATTTTAGACTCTGAAGGGTTTGTGATGTCATTTGTGCACCTTATTAGCCTGGGCAGA
ATGGCTAATGGTCACACTTCTAATACACACTTTAAGTGTTATTAAGCATTGCATGAGGTTTAAAAAATTACAAAGTAGAAGAAGGAGGAC
CTCAAGAAATTAGTATAAAACAAGAGAATGTTATAAATATTTATGAGGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCA
AGCTATCCTTTTGATGATTCTCCAGAACATAAGGCCACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAA
GCTTATGCTTCAAACCACCCCATAATGAAAACTGGTGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAAC
GGCGCACATTGGTATGATGTGGAAGGTGGTATGCAAGATTACAATTATGTGTGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGT
TGCAAGTACCCACCTGCTTCACAGCTTCGACAGGAATGGGAGAACAATCGTGAGTCTTTGATCACATTGATTGAAAAGCTCCTTCGAGAA
CTCATAGAACGGAAGACCAGCTCCTTGGATCCCAACGATCAGGTGGCCATGGGAAGGCAGTGGCTTGCAATCCAGAAGTTACGAAGCAAA
ATCCACAAAAAAGTAGATAGGAAAGCCAGCAAAGGCAGGAAACTTCGGTTTCATGTCCTTAGCAAGCTACTGAGTTTCATGGCACCTATT
GACCATACTACAATGAATGATGATGCCAGGACAGAACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGACGAAGGCCACGGGGAT
TGACATCGCCCACCTCCGACACCCAGTGGGCGCCTTGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGTGACTTTATGGGGCTGA
GCTAGTAGGGAAGCCCCTGGAAAGATGCTGCGTTCCGAACCTGTGCCTAATACACGCAAGGGCGCTGTCCCGCCCAACCCCGCCTTTAAA

>In-frame_ENST00000543464_ENST00000225402_TCGA-A2-A1FW_CPD_chr17_28748001_+_AATF_chr17_35376303_length(amino acids)=226AA_start in transcript=402_stop in transcript=1082
MRFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDY
NYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRKASKGRK

--------------------------------------------------------------
>In-frame_ENST00000225719_ENST00000225402_TCGA-A2-A1FW-01A_CPD_chr17_28748000_+_AATF_chr17_35376303_length(transcript)=1705nt_BP=1213nt
GGGGATCCGGCGGGCCCCCGCCGCCCGGAGCGCTGAGCCGCGGGAGCGGAGCCGGGGTTAGCGGCGCTGCTGGAAGATGGCGAGCGGCCG
GGACGAGCGGCCGCCTTGGCGGCTAGGGCGGCTCCTGTTGCTCATGTGCCTGCTGCTGCTGGGGAGCTCGGCCCGGGCGGCTCACATCAA
GAAGGCGGAGGCGACTACCACAACTACGAGCGCGGGCGCCGAGGCGGCCGAGGGCCAGTTCGACCGCTACTACCACGAAGAGGAGTTGGA
GTCGGCGCTGAGGGAGGCGGCGGCCGCGGGCCTCCCCGGCCTGGCCCGCCTCTTTAGCATCGGCCGCTCGGTGGAAGGCCGGCCGCTGTG
GGTGCTTCGCCTCACCGCCGGCCTGGGGTCGCTAATCCCTGAGGGCGACGCGGGGCCTGACGCTGCCGGGCCCGACGCTGCGGGGCCGCT
GCTGCCCGGCCGGCCCCAGGTGAAGCTGGTGGGCAACATGCATGGCGACGAGACCGTGTCGCGCCAGGTGTTGATCTACTTGGCCCGCGA
GCTGGCGGCCGGCTACCGCCGCGGGGACCCGCGCCTGGTCCGCCTGCTCAACACCACCGACGTGTACCTGCTGCCCAGCCTCAACCCCGA
TGGCTTCGAGCGTGCCCGCGAGGGCGACTGTGGCTTCGGCGACGGCGGCCCGTCCGGGGCCAGCGGCCGCGACAATAGTCGCGGCCGCGA
CCTCAACCGAAGCTTTCCCGACCAGTTTAGCACCGGCGAACCCCCCGCCCTGGACGAGGTGCCCGAGGTGCGCGCCCTCATCGAGTGGAT
CCGCAGGAACAAGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCAAGCTATCCTTTTGATGATTCTCCAGAACATAAGGC
CACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCCATAATGAAAACTGG
TGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAACGGCGCACATTGGTATGATGTGGAAGGTGGTATGCA
AGATTACAATTATGTGTGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGTTGCAAGTACCCACCTGCTTCACAGCTTCGACAGGA
ATGGGAGAACAATCGTGAGTCTTTGATCACATTGATTGAAAAGCTCCTTCGAGAACTCATAGAACGGAAGACCAGCTCCTTGGATCCCAA
CGATCAGGTGGCCATGGGAAGGCAGTGGCTTGCAATCCAGAAGTTACGAAGCAAAATCCACAAAAAAGTAGATAGGAAAGCCAGCAAAGG
CAGGAAACTTCGGTTTCATGTCCTTAGCAAGCTACTGAGTTTCATGGCACCTATTGACCATACTACAATGAATGATGATGCCAGGACAGA
ACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGACGAAGGCCACGGGGATTGACATCGCCCACCTCCGACACCCAGTGGGCGCCT
TGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGTGACTTTATGGGGCTGAGCTAGTAGGGAAGCCCCTGGAAAGATGCTGCGTTC

>In-frame_ENST00000225719_ENST00000225402_TCGA-A2-A1FW-01A_CPD_chr17_28748000_+_AATF_chr17_35376303_length(amino acids)=473AA_start in transcript=76_stop in transcript=1497
MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVE
GRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLP
SLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDS
PEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPAS
QLRQEWENNRESLITLIEKLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTTMND

--------------------------------------------------------------
>In-frame_ENST00000543464_ENST00000225402_TCGA-A2-A1FW-01A_CPD_chr17_28748000_+_AATF_chr17_35376303_length(transcript)=1290nt_BP=798nt
AGTGTGGCTGGGACTTAGAATTAGGCAATCTGATTCCCGATAGTCCTCTTAGCCACGGAGGGACACTGGAGCCCAAAAATGGCAGATGAT
ATTCCCAGGATCTTCCCCTTGCCTATTTGACAGAAGCTGATTTTTCTCCAATTTTTACCTCTGACTCAGCTTAAGAAGATATGGACTTAG
CTGGAGAACTTGCACAGATCTGTGAGCCGCTTCATTTTAGACTCTGAAGGGTTTGTGATGTCATTTGTGCACCTTATTAGCCTGGGCAGA
ATGGCTAATGGTCACACTTCTAATACACACTTTAAGTGTTATTAAGCATTGCATGAGGTTTAAAAAATTACAAAGTAGAAGAAGGAGGAC
CTCAAGAAATTAGTATAAAACAAGAGAATGTTATAAATATTTATGAGGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCA
AGCTATCCTTTTGATGATTCTCCAGAACATAAGGCCACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAA
GCTTATGCTTCAAACCACCCCATAATGAAAACTGGTGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAAC
GGCGCACATTGGTATGATGTGGAAGGTGGTATGCAAGATTACAATTATGTGTGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGT
TGCAAGTACCCACCTGCTTCACAGCTTCGACAGGAATGGGAGAACAATCGTGAGTCTTTGATCACATTGATTGAAAAGCTCCTTCGAGAA
CTCATAGAACGGAAGACCAGCTCCTTGGATCCCAACGATCAGGTGGCCATGGGAAGGCAGTGGCTTGCAATCCAGAAGTTACGAAGCAAA
ATCCACAAAAAAGTAGATAGGAAAGCCAGCAAAGGCAGGAAACTTCGGTTTCATGTCCTTAGCAAGCTACTGAGTTTCATGGCACCTATT
GACCATACTACAATGAATGATGATGCCAGGACAGAACTGTACCGCTCTCTTTTTGGCCAGCTCCACCCTCCCGACGAAGGCCACGGGGAT
TGACATCGCCCACCTCCGACACCCAGTGGGCGCCTTGGCTGGTGCGGCTGCTGGTCCAGATGGAGGAAACCAGTGACTTTATGGGGCTGA
GCTAGTAGGGAAGCCCCTGGAAAGATGCTGCGTTCCGAACCTGTGCCTAATACACGCAAGGGCGCTGTCCCGCCCAACCCCGCCTTTAAA

>In-frame_ENST00000543464_ENST00000225402_TCGA-A2-A1FW-01A_CPD_chr17_28748000_+_AATF_chr17_35376303_length(amino acids)=226AA_start in transcript=402_stop in transcript=1082
MRFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDY
NYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKLLRELIERKTSSLDPNDQVAMGRQWLAIQKLRSKIHKKVDRKASKGRK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CPD-AATF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CPD-AATF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CPD-AATF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource