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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CPD-MYL4 (FusionGDB2 ID:18946)

Fusion Gene Summary for CPD-MYL4

check button Fusion gene summary
Fusion gene informationFusion gene name: CPD-MYL4
Fusion gene ID: 18946
HgeneTgene
Gene symbol

CPD

MYL4

Gene ID

9455

4635

Gene namehomer scaffold protein 2myosin light chain 4
SynonymsACPD|CPD|DFNA68|HOMER-2|VESL-2ALC1|AMLC|GT1|PRO1957
Cytomap

15q25.2

17q21.32

Type of geneprotein-codingprotein-coding
Descriptionhomer protein homolog 2cupidinhomer homolog 2homer homolog 3homer scaffolding protein 2homer, neuronal immediate early gene, 2myosin light chain 4atrial myosin light chain 1myosin light chain 1, embryonic muscle/atrial isoformmyosin light chain alkali GT-1 isoformmyosin, atrial/fetal muscle, light chainmyosin, light chain 4, alkali; atrial, embryonicmyosin, light polypepti
Modification date2020031320200313
UniProtAcc.

P12829

Ensembl transtripts involved in fusion geneENST00000225719, ENST00000543464, 
ENST00000584051, 		ENST00000572316, 
ENST00000354968, ENST00000393450, 
Fusion gene scores* DoF score26 X 16 X 10=41609 X 5 X 7=315
# samples 2615
** MAII scorelog2(26/4160*10)=-4
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/315*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CPD [Title/Abstract] AND MYL4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCPD(28712254)-MYL4(45286755), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CPD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MYL4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-2111-01ACPDchr17

28712254

+MYL4chr17

45286755

+
ChimerDB4OVTCGA-61-2111CPDchr17

28712254

+MYL4chr17

45286754

+
ChimerDB4OVTCGA-61-2111-01ACPDchr17

28712254

+MYL4chr17

45286755

+
ChimerDB4OVTCGA-61-2111-01ACPDchr17

28712254

+MYL4chr17

45297270

+


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Fusion Gene ORF analysis for CPD-MYL4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000225719ENST00000572316CPDchr17

28712254

+MYL4chr17

45286755

+
5CDS-5UTRENST00000225719ENST00000354968CPDchr17

28712254

+MYL4chr17

45286755

+
5CDS-5UTRENST00000225719ENST00000393450CPDchr17

28712254

+MYL4chr17

45286755

+
5CDS-5UTRENST00000543464ENST00000572316CPDchr17

28712254

+MYL4chr17

45286755

+
5CDS-5UTRENST00000543464ENST00000354968CPDchr17

28712254

+MYL4chr17

45286755

+
5CDS-5UTRENST00000543464ENST00000393450CPDchr17

28712254

+MYL4chr17

45286755

+
intron-5UTRENST00000584051ENST00000572316CPDchr17

28712254

+MYL4chr17

45286755

+
intron-5UTRENST00000584051ENST00000354968CPDchr17

28712254

+MYL4chr17

45286755

+
intron-5UTRENST00000584051ENST00000393450CPDchr17

28712254

+MYL4chr17

45286755

+
5CDS-5UTRENST00000225719ENST00000572316CPDchr17

28712254

+MYL4chr17

45286754

+
5CDS-5UTRENST00000225719ENST00000354968CPDchr17

28712254

+MYL4chr17

45286754

+
5CDS-5UTRENST00000225719ENST00000393450CPDchr17

28712254

+MYL4chr17

45286754

+
5CDS-5UTRENST00000543464ENST00000572316CPDchr17

28712254

+MYL4chr17

45286754

+
5CDS-5UTRENST00000543464ENST00000354968CPDchr17

28712254

+MYL4chr17

45286754

+
5CDS-5UTRENST00000543464ENST00000393450CPDchr17

28712254

+MYL4chr17

45286754

+
intron-5UTRENST00000584051ENST00000572316CPDchr17

28712254

+MYL4chr17

45286754

+
intron-5UTRENST00000584051ENST00000354968CPDchr17

28712254

+MYL4chr17

45286754

+
intron-5UTRENST00000584051ENST00000393450CPDchr17

28712254

+MYL4chr17

45286754

+
In-frameENST00000225719ENST00000572316CPDchr17

28712254

+MYL4chr17

45297270

+
In-frameENST00000225719ENST00000354968CPDchr17

28712254

+MYL4chr17

45297270

+
In-frameENST00000225719ENST00000393450CPDchr17

28712254

+MYL4chr17

45297270

+
In-frameENST00000543464ENST00000572316CPDchr17

28712254

+MYL4chr17

45297270

+
In-frameENST00000543464ENST00000354968CPDchr17

28712254

+MYL4chr17

45297270

+
In-frameENST00000543464ENST00000393450CPDchr17

28712254

+MYL4chr17

45297270

+
intron-3CDSENST00000584051ENST00000572316CPDchr17

28712254

+MYL4chr17

45297270

+
intron-3CDSENST00000584051ENST00000354968CPDchr17

28712254

+MYL4chr17

45297270

+
intron-3CDSENST00000584051ENST00000393450CPDchr17

28712254

+MYL4chr17

45297270

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000225719CPDchr1728712254+ENST00000572316MYL4chr1745297270+16661070761500474
ENST00000225719CPDchr1728712254+ENST00000354968MYL4chr1745297270+16861070761500474
ENST00000225719CPDchr1728712254+ENST00000393450MYL4chr1745297270+16871070761500474
ENST00000543464CPDchr1728712254+ENST00000572316MYL4chr1745297270+12516554021085227
ENST00000543464CPDchr1728712254+ENST00000354968MYL4chr1745297270+12716554021085227
ENST00000543464CPDchr1728712254+ENST00000393450MYL4chr1745297270+12726554021085227

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000225719ENST00000572316CPDchr1728712254+MYL4chr1745297270+0.0056385070.9943615
ENST00000225719ENST00000354968CPDchr1728712254+MYL4chr1745297270+0.0059612690.9940387
ENST00000225719ENST00000393450CPDchr1728712254+MYL4chr1745297270+0.0060070520.993993
ENST00000543464ENST00000572316CPDchr1728712254+MYL4chr1745297270+0.0013539850.9986461
ENST00000543464ENST00000354968CPDchr1728712254+MYL4chr1745297270+0.0015248950.99847513
ENST00000543464ENST00000393450CPDchr1728712254+MYL4chr1745297270+0.001523580.99847645

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Fusion Genomic Features for CPD-MYL4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CPDchr1728712254+MYL4chr1745297269+3.24E-070.99999964
CPDchr1728712254+MYL4chr1745286754+8.55E-080.9999999
CPDchr1728712254+MYL4chr1745286754+8.55E-080.9999999
CPDchr1728712254+MYL4chr1745297269+3.24E-070.99999964
CPDchr1728712254+MYL4chr1745286754+8.55E-080.9999999
CPDchr1728712254+MYL4chr1745286754+8.55E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CPD-MYL4


check button Go to

FGviewer for the breakpoints of chr17:28712254-chr17:45297270

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MYL4

P12829

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Regulatory light chain of myosin. Does not bind calcium.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPDchr17:28712254chr17:45297270ENST00000225719+221162_164331.33333333333331381.0MotifCell attachment site
TgeneMYL4chr17:28712254chr17:45297270ENST0000035496828130_16554.333333333333336223.33333333333334DomainEF-hand 2
TgeneMYL4chr17:28712254chr17:45297270ENST0000039345017130_16554.333333333333336185.0DomainEF-hand 2
TgeneMYL4chr17:28712254chr17:45297270ENST0000057231628130_16554.333333333333336229.0DomainEF-hand 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPDchr17:28712254chr17:45297270ENST00000543464+221162_16484.333333333333331134.0MotifCell attachment site
HgeneCPDchr17:28712254chr17:45297270ENST00000225719+22132_493331.33333333333331381.0RegionNote=Carboxypeptidase-like 1
HgeneCPDchr17:28712254chr17:45297270ENST00000225719+221494_897331.33333333333331381.0RegionNote=Carboxypeptidase-like 2
HgeneCPDchr17:28712254chr17:45297270ENST00000225719+221898_1299331.33333333333331381.0RegionNote=Carboxypeptidase-like 3
HgeneCPDchr17:28712254chr17:45297270ENST00000543464+22132_49384.333333333333331134.0RegionNote=Carboxypeptidase-like 1
HgeneCPDchr17:28712254chr17:45297270ENST00000543464+221494_89784.333333333333331134.0RegionNote=Carboxypeptidase-like 2
HgeneCPDchr17:28712254chr17:45297270ENST00000543464+221898_129984.333333333333331134.0RegionNote=Carboxypeptidase-like 3
HgeneCPDchr17:28712254chr17:45297270ENST00000225719+2211321_1380331.33333333333331381.0Topological domainCytoplasmic
HgeneCPDchr17:28712254chr17:45297270ENST00000225719+22132_1299331.33333333333331381.0Topological domainExtracellular
HgeneCPDchr17:28712254chr17:45297270ENST00000543464+2211321_138084.333333333333331134.0Topological domainCytoplasmic
HgeneCPDchr17:28712254chr17:45297270ENST00000543464+22132_129984.333333333333331134.0Topological domainExtracellular
HgeneCPDchr17:28712254chr17:45297270ENST00000225719+2211300_1320331.33333333333331381.0TransmembraneHelical
HgeneCPDchr17:28712254chr17:45297270ENST00000543464+2211300_132084.333333333333331134.0TransmembraneHelical
TgeneMYL4chr17:28712254chr17:45297270ENST000003549682851_8854.333333333333336223.33333333333334DomainEF-hand 1
TgeneMYL4chr17:28712254chr17:45297270ENST000003934501751_8854.333333333333336185.0DomainEF-hand 1
TgeneMYL4chr17:28712254chr17:45297270ENST000005723162851_8854.333333333333336229.0DomainEF-hand 1


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Fusion Gene Sequence for CPD-MYL4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000225719_ENST00000572316_TCGA-61-2111-01A_CPD_chr17_28712254_+_MYL4_chr17_45297270_length(transcript)=1666nt_BP=1070nt
GGGGATCCGGCGGGCCCCCGCCGCCCGGAGCGCTGAGCCGCGGGAGCGGAGCCGGGGTTAGCGGCGCTGCTGGAAGATGGCGAGCGGCCG
GGACGAGCGGCCGCCTTGGCGGCTAGGGCGGCTCCTGTTGCTCATGTGCCTGCTGCTGCTGGGGAGCTCGGCCCGGGCGGCTCACATCAA
GAAGGCGGAGGCGACTACCACAACTACGAGCGCGGGCGCCGAGGCGGCCGAGGGCCAGTTCGACCGCTACTACCACGAAGAGGAGTTGGA
GTCGGCGCTGAGGGAGGCGGCGGCCGCGGGCCTCCCCGGCCTGGCCCGCCTCTTTAGCATCGGCCGCTCGGTGGAAGGCCGGCCGCTGTG
GGTGCTTCGCCTCACCGCCGGCCTGGGGTCGCTAATCCCTGAGGGCGACGCGGGGCCTGACGCTGCCGGGCCCGACGCTGCGGGGCCGCT
GCTGCCCGGCCGGCCCCAGGTGAAGCTGGTGGGCAACATGCATGGCGACGAGACCGTGTCGCGCCAGGTGTTGATCTACTTGGCCCGCGA
GCTGGCGGCCGGCTACCGCCGCGGGGACCCGCGCCTGGTCCGCCTGCTCAACACCACCGACGTGTACCTGCTGCCCAGCCTCAACCCCGA
TGGCTTCGAGCGTGCCCGCGAGGGCGACTGTGGCTTCGGCGACGGCGGCCCGTCCGGGGCCAGCGGCCGCGACAATAGTCGCGGCCGCGA
CCTCAACCGAAGCTTTCCCGACCAGTTTAGCACCGGCGAACCCCCCGCCCTGGACGAGGTGCCCGAGGTGCGCGCCCTCATCGAGTGGAT
CCGCAGGAACAAGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCAAGCTATCCTTTTGATGATTCTCCAGAACATAAGGC
CACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCCATAATGAAAACTGG
TGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAACGGCGCACATTGGTATGATGTGGAAGAGTTCAAAGA
GGCCTTTTCATTGTTTGACCGGACCCCGACTGGAGAGATGAAGATCACCTACGGCCAGTGCGGGGATGTACTGCGGGCCCTGGGCCAGAA
CCCTACCAATGCCGAGGTGCTGCGTGTGCTGGGCAAGCCCAAGCCTGAAGAGATGAATGTCAAGATGCTGGACTTTGAGACGTTCTTGCC
CATCCTGCAGCACATTTCCCGCAACAAGGAGCAGGGCACCTATGAGGACTTCGTGGAGGGCCTGCGTGTCTTTGACAAGGAGAGCAATGG
CACGGTCATGGGTGCTGAGCTTCGGCACGTCCTTGCCACCCTGGGAGAGAAGATGACTGAGGCTGAAGTGGAGCAGCTGTTAGCTGGGCA
AGAGGATGCCAATGGCTGCATCAATTATGAAGCCTTTGTCAAGCACATCATGTCAGGGTGAAGCAGAGTCTTCCAGGTGCCTGGCCCTTG
GCTTTAGCCATACCAGGGTGAGTTAAAGAGAGGCCCCGGCTGGGTGAGCTGAGATGGAGTCCTCGACTTATCACCACACCACTGCCCCAA

>In-frame_ENST00000225719_ENST00000572316_TCGA-61-2111-01A_CPD_chr17_28712254_+_MYL4_chr17_45297270_length(amino acids)=474AA_start in transcript=76_stop in transcript=1500
MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVE
GRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLP
SLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDS
PEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEEFKEAFSLFDRTPTGEMKITYGQCGDVLR
ALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQ

--------------------------------------------------------------
>In-frame_ENST00000225719_ENST00000354968_TCGA-61-2111-01A_CPD_chr17_28712254_+_MYL4_chr17_45297270_length(transcript)=1686nt_BP=1070nt
GGGGATCCGGCGGGCCCCCGCCGCCCGGAGCGCTGAGCCGCGGGAGCGGAGCCGGGGTTAGCGGCGCTGCTGGAAGATGGCGAGCGGCCG
GGACGAGCGGCCGCCTTGGCGGCTAGGGCGGCTCCTGTTGCTCATGTGCCTGCTGCTGCTGGGGAGCTCGGCCCGGGCGGCTCACATCAA
GAAGGCGGAGGCGACTACCACAACTACGAGCGCGGGCGCCGAGGCGGCCGAGGGCCAGTTCGACCGCTACTACCACGAAGAGGAGTTGGA
GTCGGCGCTGAGGGAGGCGGCGGCCGCGGGCCTCCCCGGCCTGGCCCGCCTCTTTAGCATCGGCCGCTCGGTGGAAGGCCGGCCGCTGTG
GGTGCTTCGCCTCACCGCCGGCCTGGGGTCGCTAATCCCTGAGGGCGACGCGGGGCCTGACGCTGCCGGGCCCGACGCTGCGGGGCCGCT
GCTGCCCGGCCGGCCCCAGGTGAAGCTGGTGGGCAACATGCATGGCGACGAGACCGTGTCGCGCCAGGTGTTGATCTACTTGGCCCGCGA
GCTGGCGGCCGGCTACCGCCGCGGGGACCCGCGCCTGGTCCGCCTGCTCAACACCACCGACGTGTACCTGCTGCCCAGCCTCAACCCCGA
TGGCTTCGAGCGTGCCCGCGAGGGCGACTGTGGCTTCGGCGACGGCGGCCCGTCCGGGGCCAGCGGCCGCGACAATAGTCGCGGCCGCGA
CCTCAACCGAAGCTTTCCCGACCAGTTTAGCACCGGCGAACCCCCCGCCCTGGACGAGGTGCCCGAGGTGCGCGCCCTCATCGAGTGGAT
CCGCAGGAACAAGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCAAGCTATCCTTTTGATGATTCTCCAGAACATAAGGC
CACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCCATAATGAAAACTGG
TGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAACGGCGCACATTGGTATGATGTGGAAGAGTTCAAAGA
GGCCTTTTCATTGTTTGACCGGACCCCGACTGGAGAGATGAAGATCACCTACGGCCAGTGCGGGGATGTACTGCGGGCCCTGGGCCAGAA
CCCTACCAATGCCGAGGTGCTGCGTGTGCTGGGCAAGCCCAAGCCTGAAGAGATGAATGTCAAGATGCTGGACTTTGAGACGTTCTTGCC
CATCCTGCAGCACATTTCCCGCAACAAGGAGCAGGGCACCTATGAGGACTTCGTGGAGGGCCTGCGTGTCTTTGACAAGGAGAGCAATGG
CACGGTCATGGGTGCTGAGCTTCGGCACGTCCTTGCCACCCTGGGAGAGAAGATGACTGAGGCTGAAGTGGAGCAGCTGTTAGCTGGGCA
AGAGGATGCCAATGGCTGCATCAATTATGAAGCCTTTGTCAAGCACATCATGTCAGGGTGAAGCAGAGTCTTCCAGGTGCCTGGCCCTTG
GCTTTAGCCATACCAGGGTGAGTTAAAGAGAGGCCCCGGCTGGGTGAGCTGAGATGGAGTCCTCGACTTATCACCACACCACTGCCCCAA

>In-frame_ENST00000225719_ENST00000354968_TCGA-61-2111-01A_CPD_chr17_28712254_+_MYL4_chr17_45297270_length(amino acids)=474AA_start in transcript=76_stop in transcript=1500
MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVE
GRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLP
SLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDS
PEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEEFKEAFSLFDRTPTGEMKITYGQCGDVLR
ALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQ

--------------------------------------------------------------
>In-frame_ENST00000225719_ENST00000393450_TCGA-61-2111-01A_CPD_chr17_28712254_+_MYL4_chr17_45297270_length(transcript)=1687nt_BP=1070nt
GGGGATCCGGCGGGCCCCCGCCGCCCGGAGCGCTGAGCCGCGGGAGCGGAGCCGGGGTTAGCGGCGCTGCTGGAAGATGGCGAGCGGCCG
GGACGAGCGGCCGCCTTGGCGGCTAGGGCGGCTCCTGTTGCTCATGTGCCTGCTGCTGCTGGGGAGCTCGGCCCGGGCGGCTCACATCAA
GAAGGCGGAGGCGACTACCACAACTACGAGCGCGGGCGCCGAGGCGGCCGAGGGCCAGTTCGACCGCTACTACCACGAAGAGGAGTTGGA
GTCGGCGCTGAGGGAGGCGGCGGCCGCGGGCCTCCCCGGCCTGGCCCGCCTCTTTAGCATCGGCCGCTCGGTGGAAGGCCGGCCGCTGTG
GGTGCTTCGCCTCACCGCCGGCCTGGGGTCGCTAATCCCTGAGGGCGACGCGGGGCCTGACGCTGCCGGGCCCGACGCTGCGGGGCCGCT
GCTGCCCGGCCGGCCCCAGGTGAAGCTGGTGGGCAACATGCATGGCGACGAGACCGTGTCGCGCCAGGTGTTGATCTACTTGGCCCGCGA
GCTGGCGGCCGGCTACCGCCGCGGGGACCCGCGCCTGGTCCGCCTGCTCAACACCACCGACGTGTACCTGCTGCCCAGCCTCAACCCCGA
TGGCTTCGAGCGTGCCCGCGAGGGCGACTGTGGCTTCGGCGACGGCGGCCCGTCCGGGGCCAGCGGCCGCGACAATAGTCGCGGCCGCGA
CCTCAACCGAAGCTTTCCCGACCAGTTTAGCACCGGCGAACCCCCCGCCCTGGACGAGGTGCCCGAGGTGCGCGCCCTCATCGAGTGGAT
CCGCAGGAACAAGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCAAGCTATCCTTTTGATGATTCTCCAGAACATAAGGC
CACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCCATAATGAAAACTGG
TGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAACGGCGCACATTGGTATGATGTGGAAGAGTTCAAAGA
GGCCTTTTCATTGTTTGACCGGACCCCGACTGGAGAGATGAAGATCACCTACGGCCAGTGCGGGGATGTACTGCGGGCCCTGGGCCAGAA
CCCTACCAATGCCGAGGTGCTGCGTGTGCTGGGCAAGCCCAAGCCTGAAGAGATGAATGTCAAGATGCTGGACTTTGAGACGTTCTTGCC
CATCCTGCAGCACATTTCCCGCAACAAGGAGCAGGGCACCTATGAGGACTTCGTGGAGGGCCTGCGTGTCTTTGACAAGGAGAGCAATGG
CACGGTCATGGGTGCTGAGCTTCGGCACGTCCTTGCCACCCTGGGAGAGAAGATGACTGAGGCTGAAGTGGAGCAGCTGTTAGCTGGGCA
AGAGGATGCCAATGGCTGCATCAATTATGAAGCCTTTGTCAAGCACATCATGTCAGGGTGAAGCAGAGTCTTCCAGGTGCCTGGCCCTTG
GCTTTAGCCATACCAGGGTGAGTTAAAGAGAGGCCCCGGCTGGGTGAGCTGAGATGGAGTCCTCGACTTATCACCACACCACTGCCCCAA

>In-frame_ENST00000225719_ENST00000393450_TCGA-61-2111-01A_CPD_chr17_28712254_+_MYL4_chr17_45297270_length(amino acids)=474AA_start in transcript=76_stop in transcript=1500
MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVE
GRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLP
SLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDS
PEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEEFKEAFSLFDRTPTGEMKITYGQCGDVLR
ALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQ

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>In-frame_ENST00000543464_ENST00000572316_TCGA-61-2111-01A_CPD_chr17_28712254_+_MYL4_chr17_45297270_length(transcript)=1251nt_BP=655nt
AGTGTGGCTGGGACTTAGAATTAGGCAATCTGATTCCCGATAGTCCTCTTAGCCACGGAGGGACACTGGAGCCCAAAAATGGCAGATGAT
ATTCCCAGGATCTTCCCCTTGCCTATTTGACAGAAGCTGATTTTTCTCCAATTTTTACCTCTGACTCAGCTTAAGAAGATATGGACTTAG
CTGGAGAACTTGCACAGATCTGTGAGCCGCTTCATTTTAGACTCTGAAGGGTTTGTGATGTCATTTGTGCACCTTATTAGCCTGGGCAGA
ATGGCTAATGGTCACACTTCTAATACACACTTTAAGTGTTATTAAGCATTGCATGAGGTTTAAAAAATTACAAAGTAGAAGAAGGAGGAC
CTCAAGAAATTAGTATAAAACAAGAGAATGTTATAAATATTTATGAGGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCA
AGCTATCCTTTTGATGATTCTCCAGAACATAAGGCCACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAA
GCTTATGCTTCAAACCACCCCATAATGAAAACTGGTGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAAC
GGCGCACATTGGTATGATGTGGAAGAGTTCAAAGAGGCCTTTTCATTGTTTGACCGGACCCCGACTGGAGAGATGAAGATCACCTACGGC
CAGTGCGGGGATGTACTGCGGGCCCTGGGCCAGAACCCTACCAATGCCGAGGTGCTGCGTGTGCTGGGCAAGCCCAAGCCTGAAGAGATG
AATGTCAAGATGCTGGACTTTGAGACGTTCTTGCCCATCCTGCAGCACATTTCCCGCAACAAGGAGCAGGGCACCTATGAGGACTTCGTG
GAGGGCCTGCGTGTCTTTGACAAGGAGAGCAATGGCACGGTCATGGGTGCTGAGCTTCGGCACGTCCTTGCCACCCTGGGAGAGAAGATG
ACTGAGGCTGAAGTGGAGCAGCTGTTAGCTGGGCAAGAGGATGCCAATGGCTGCATCAATTATGAAGCCTTTGTCAAGCACATCATGTCA
GGGTGAAGCAGAGTCTTCCAGGTGCCTGGCCCTTGGCTTTAGCCATACCAGGGTGAGTTAAAGAGAGGCCCCGGCTGGGTGAGCTGAGAT

>In-frame_ENST00000543464_ENST00000572316_TCGA-61-2111-01A_CPD_chr17_28712254_+_MYL4_chr17_45297270_length(amino acids)=227AA_start in transcript=402_stop in transcript=1085
MRFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEEFKEAF
SLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTV

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>In-frame_ENST00000543464_ENST00000354968_TCGA-61-2111-01A_CPD_chr17_28712254_+_MYL4_chr17_45297270_length(transcript)=1271nt_BP=655nt
AGTGTGGCTGGGACTTAGAATTAGGCAATCTGATTCCCGATAGTCCTCTTAGCCACGGAGGGACACTGGAGCCCAAAAATGGCAGATGAT
ATTCCCAGGATCTTCCCCTTGCCTATTTGACAGAAGCTGATTTTTCTCCAATTTTTACCTCTGACTCAGCTTAAGAAGATATGGACTTAG
CTGGAGAACTTGCACAGATCTGTGAGCCGCTTCATTTTAGACTCTGAAGGGTTTGTGATGTCATTTGTGCACCTTATTAGCCTGGGCAGA
ATGGCTAATGGTCACACTTCTAATACACACTTTAAGTGTTATTAAGCATTGCATGAGGTTTAAAAAATTACAAAGTAGAAGAAGGAGGAC
CTCAAGAAATTAGTATAAAACAAGAGAATGTTATAAATATTTATGAGGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCA
AGCTATCCTTTTGATGATTCTCCAGAACATAAGGCCACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAA
GCTTATGCTTCAAACCACCCCATAATGAAAACTGGTGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAAC
GGCGCACATTGGTATGATGTGGAAGAGTTCAAAGAGGCCTTTTCATTGTTTGACCGGACCCCGACTGGAGAGATGAAGATCACCTACGGC
CAGTGCGGGGATGTACTGCGGGCCCTGGGCCAGAACCCTACCAATGCCGAGGTGCTGCGTGTGCTGGGCAAGCCCAAGCCTGAAGAGATG
AATGTCAAGATGCTGGACTTTGAGACGTTCTTGCCCATCCTGCAGCACATTTCCCGCAACAAGGAGCAGGGCACCTATGAGGACTTCGTG
GAGGGCCTGCGTGTCTTTGACAAGGAGAGCAATGGCACGGTCATGGGTGCTGAGCTTCGGCACGTCCTTGCCACCCTGGGAGAGAAGATG
ACTGAGGCTGAAGTGGAGCAGCTGTTAGCTGGGCAAGAGGATGCCAATGGCTGCATCAATTATGAAGCCTTTGTCAAGCACATCATGTCA
GGGTGAAGCAGAGTCTTCCAGGTGCCTGGCCCTTGGCTTTAGCCATACCAGGGTGAGTTAAAGAGAGGCCCCGGCTGGGTGAGCTGAGAT
GGAGTCCTCGACTTATCACCACACCACTGCCCCAAGGACCTTACAGGCCCTCCCTGTTAATAAACAGCTCTAACACGGCCAGGCTGGGCT

>In-frame_ENST00000543464_ENST00000354968_TCGA-61-2111-01A_CPD_chr17_28712254_+_MYL4_chr17_45297270_length(amino acids)=227AA_start in transcript=402_stop in transcript=1085
MRFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEEFKEAF
SLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTV

--------------------------------------------------------------
>In-frame_ENST00000543464_ENST00000393450_TCGA-61-2111-01A_CPD_chr17_28712254_+_MYL4_chr17_45297270_length(transcript)=1272nt_BP=655nt
AGTGTGGCTGGGACTTAGAATTAGGCAATCTGATTCCCGATAGTCCTCTTAGCCACGGAGGGACACTGGAGCCCAAAAATGGCAGATGAT
ATTCCCAGGATCTTCCCCTTGCCTATTTGACAGAAGCTGATTTTTCTCCAATTTTTACCTCTGACTCAGCTTAAGAAGATATGGACTTAG
CTGGAGAACTTGCACAGATCTGTGAGCCGCTTCATTTTAGACTCTGAAGGGTTTGTGATGTCATTTGTGCACCTTATTAGCCTGGGCAGA
ATGGCTAATGGTCACACTTCTAATACACACTTTAAGTGTTATTAAGCATTGCATGAGGTTTAAAAAATTACAAAGTAGAAGAAGGAGGAC
CTCAAGAAATTAGTATAAAACAAGAGAATGTTATAAATATTTATGAGGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCA
AGCTATCCTTTTGATGATTCTCCAGAACATAAGGCCACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAA
GCTTATGCTTCAAACCACCCCATAATGAAAACTGGTGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAAC
GGCGCACATTGGTATGATGTGGAAGAGTTCAAAGAGGCCTTTTCATTGTTTGACCGGACCCCGACTGGAGAGATGAAGATCACCTACGGC
CAGTGCGGGGATGTACTGCGGGCCCTGGGCCAGAACCCTACCAATGCCGAGGTGCTGCGTGTGCTGGGCAAGCCCAAGCCTGAAGAGATG
AATGTCAAGATGCTGGACTTTGAGACGTTCTTGCCCATCCTGCAGCACATTTCCCGCAACAAGGAGCAGGGCACCTATGAGGACTTCGTG
GAGGGCCTGCGTGTCTTTGACAAGGAGAGCAATGGCACGGTCATGGGTGCTGAGCTTCGGCACGTCCTTGCCACCCTGGGAGAGAAGATG
ACTGAGGCTGAAGTGGAGCAGCTGTTAGCTGGGCAAGAGGATGCCAATGGCTGCATCAATTATGAAGCCTTTGTCAAGCACATCATGTCA
GGGTGAAGCAGAGTCTTCCAGGTGCCTGGCCCTTGGCTTTAGCCATACCAGGGTGAGTTAAAGAGAGGCCCCGGCTGGGTGAGCTGAGAT
GGAGTCCTCGACTTATCACCACACCACTGCCCCAAGGACCTTACAGGCCCTCCCTGTTAATAAACAGCTCTAACACGGCCAGGCTGGGCT

>In-frame_ENST00000543464_ENST00000393450_TCGA-61-2111-01A_CPD_chr17_28712254_+_MYL4_chr17_45297270_length(amino acids)=227AA_start in transcript=402_stop in transcript=1085
MRFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEEFKEAF
SLFDRTPTGEMKITYGQCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDKESNGTV

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Fusion Gene PPI Analysis for CPD-MYL4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CPD-MYL4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CPD-MYL4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMYL4C0007194Hypertrophic Cardiomyopathy1CTD_human
TgeneMYL4C1843687ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)1ORPHANET
TgeneMYL4C4310636ATRIAL FIBRILLATION, FAMILIAL, 181CTD_human;UNIPROT
TgeneMYL4C4551472Hypertrophic obstructive cardiomyopathy1CTD_human