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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CPM-NUP107 (FusionGDB2 ID:19012)

Fusion Gene Summary for CPM-NUP107

check button Fusion gene summary
Fusion gene informationFusion gene name: CPM-NUP107
Fusion gene ID: 19012
HgeneTgene
Gene symbol

CPM

NUP107

Gene ID

1368

57122

Gene namecarboxypeptidase Mnucleoporin 107
Synonyms-NPHS11|NUP84|ODG6|ODG6; GAMOS7
Cytomap

12q15

12q15

Type of geneprotein-codingprotein-coding
Descriptioncarboxypeptidase Mrenal carboxypeptidaseurinary carboxypeptidase Bnuclear pore complex protein Nup107nucleoporin 107kDa
Modification date2020031320200313
UniProtAcc.

P57740

Ensembl transtripts involved in fusion geneENST00000546373, ENST00000551568, 
ENST00000338356, ENST00000549691, 
ENST00000229179, ENST00000378905, 
ENST00000539906, ENST00000401003, 
Fusion gene scores* DoF score15 X 8 X 7=84027 X 22 X 9=5346
# samples 1737
** MAII scorelog2(17/840*10)=-2.30485458152842
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(37/5346*10)=-3.85286266172677
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CPM [Title/Abstract] AND NUP107 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCPM(69326458)-NUP107(69135593), # samples:1
CPM(69326458)-NUP107(69084411), # samples:1
NUP107(69115932)-CPM(69279669), # samples:1
Anticipated loss of major functional domain due to fusion event.CPM-NUP107 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CPM-NUP107 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NUP107-CPM seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NUP107-CPM seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNUP107

GO:0006406

mRNA export from nucleus

11684705


check buttonFusion gene breakpoints across CPM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NUP107 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0174-01ACPMchr12

69326458

-NUP107chr12

69135593

+
ChimerDB4GBMTCGA-06-0686-01ACPMchr12

69326458

-NUP107chr12

69084411

+


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Fusion Gene ORF analysis for CPM-NUP107

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000546373ENST00000229179CPMchr12

69326458

-NUP107chr12

69135593

+
In-frameENST00000546373ENST00000378905CPMchr12

69326458

-NUP107chr12

69135593

+
In-frameENST00000546373ENST00000539906CPMchr12

69326458

-NUP107chr12

69135593

+
5CDS-intronENST00000546373ENST00000401003CPMchr12

69326458

-NUP107chr12

69135593

+
In-frameENST00000551568ENST00000229179CPMchr12

69326458

-NUP107chr12

69135593

+
In-frameENST00000551568ENST00000378905CPMchr12

69326458

-NUP107chr12

69135593

+
In-frameENST00000551568ENST00000539906CPMchr12

69326458

-NUP107chr12

69135593

+
5CDS-intronENST00000551568ENST00000401003CPMchr12

69326458

-NUP107chr12

69135593

+
In-frameENST00000338356ENST00000229179CPMchr12

69326458

-NUP107chr12

69135593

+
In-frameENST00000338356ENST00000378905CPMchr12

69326458

-NUP107chr12

69135593

+
In-frameENST00000338356ENST00000539906CPMchr12

69326458

-NUP107chr12

69135593

+
5CDS-intronENST00000338356ENST00000401003CPMchr12

69326458

-NUP107chr12

69135593

+
intron-3CDSENST00000549691ENST00000229179CPMchr12

69326458

-NUP107chr12

69135593

+
intron-3CDSENST00000549691ENST00000378905CPMchr12

69326458

-NUP107chr12

69135593

+
intron-3CDSENST00000549691ENST00000539906CPMchr12

69326458

-NUP107chr12

69135593

+
intron-intronENST00000549691ENST00000401003CPMchr12

69326458

-NUP107chr12

69135593

+
Frame-shiftENST00000546373ENST00000229179CPMchr12

69326458

-NUP107chr12

69084411

+
5CDS-5UTRENST00000546373ENST00000378905CPMchr12

69326458

-NUP107chr12

69084411

+
5CDS-5UTRENST00000546373ENST00000539906CPMchr12

69326458

-NUP107chr12

69084411

+
5CDS-intronENST00000546373ENST00000401003CPMchr12

69326458

-NUP107chr12

69084411

+
Frame-shiftENST00000551568ENST00000229179CPMchr12

69326458

-NUP107chr12

69084411

+
5CDS-5UTRENST00000551568ENST00000378905CPMchr12

69326458

-NUP107chr12

69084411

+
5CDS-5UTRENST00000551568ENST00000539906CPMchr12

69326458

-NUP107chr12

69084411

+
5CDS-intronENST00000551568ENST00000401003CPMchr12

69326458

-NUP107chr12

69084411

+
Frame-shiftENST00000338356ENST00000229179CPMchr12

69326458

-NUP107chr12

69084411

+
5CDS-5UTRENST00000338356ENST00000378905CPMchr12

69326458

-NUP107chr12

69084411

+
5CDS-5UTRENST00000338356ENST00000539906CPMchr12

69326458

-NUP107chr12

69084411

+
5CDS-intronENST00000338356ENST00000401003CPMchr12

69326458

-NUP107chr12

69084411

+
intron-3CDSENST00000549691ENST00000229179CPMchr12

69326458

-NUP107chr12

69084411

+
intron-5UTRENST00000549691ENST00000378905CPMchr12

69326458

-NUP107chr12

69084411

+
intron-5UTRENST00000549691ENST00000539906CPMchr12

69326458

-NUP107chr12

69084411

+
intron-intronENST00000549691ENST00000401003CPMchr12

69326458

-NUP107chr12

69084411

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000546373CPMchr1269326458-ENST00000229179NUP107chr1269135593+108326429753980
ENST00000546373CPMchr1269326458-ENST00000378905NUP107chr1269135593+76126429753980
ENST00000546373CPMchr1269326458-ENST00000539906NUP107chr1269135593+60926429753980
ENST00000551568CPMchr1269326458-ENST00000229179NUP107chr1269135593+104022125449680
ENST00000551568CPMchr1269326458-ENST00000378905NUP107chr1269135593+71822125449680
ENST00000551568CPMchr1269326458-ENST00000539906NUP107chr1269135593+56622125449680
ENST00000338356CPMchr1269326458-ENST00000229179NUP107chr1269135593+102620724048280
ENST00000338356CPMchr1269326458-ENST00000378905NUP107chr1269135593+70420724048280
ENST00000338356CPMchr1269326458-ENST00000539906NUP107chr1269135593+55220724048280

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000546373ENST00000229179CPMchr1269326458-NUP107chr1269135593+0.276060670.72393936
ENST00000546373ENST00000378905CPMchr1269326458-NUP107chr1269135593+0.249240320.75075966
ENST00000546373ENST00000539906CPMchr1269326458-NUP107chr1269135593+0.139236290.8607637
ENST00000551568ENST00000229179CPMchr1269326458-NUP107chr1269135593+0.33657180.66342825
ENST00000551568ENST00000378905CPMchr1269326458-NUP107chr1269135593+0.33082660.6691734
ENST00000551568ENST00000539906CPMchr1269326458-NUP107chr1269135593+0.195055010.804945
ENST00000338356ENST00000229179CPMchr1269326458-NUP107chr1269135593+0.373252630.6267473
ENST00000338356ENST00000378905CPMchr1269326458-NUP107chr1269135593+0.290510540.7094895
ENST00000338356ENST00000539906CPMchr1269326458-NUP107chr1269135593+0.170202870.8297971

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Fusion Genomic Features for CPM-NUP107


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CPMchr1269326457-NUP107chr1269084410+0.0150680080.984932
CPMchr1269326457-NUP107chr1269135592+2.76E-060.99999726
CPMchr1269326457-NUP107chr1269084410+0.0150680080.984932
CPMchr1269326457-NUP107chr1269135592+2.76E-060.99999726

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CPM-NUP107


check button Go to

FGviewer for the breakpoints of chr12:69326458-chr12:69135593

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NUP107

P57740

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269|PubMed:12552102, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:30179222}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CPM-NUP107


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000546373_ENST00000229179_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(transcript)=1083nt_BP=264nt
GTCTAGATTCTTCTTGGCCTCTCTGAGCAGCATTTCTTCCTTCTGCGTATGGGACAGGACCCTTTCTGGAATGGGGGTCTTATGACCTAC
AATCAAACAAGAACATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGGTAGCTGCGCTGGATTTCAACTACCACCGCCAGG
AAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACTTACACAGTATTGGGAAATCTGTGAAAGGATGCC
AAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCAC
AGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAG
CTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAG
TTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACC
ATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTATCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGC
TTGTTAATAAAACTATATAAAAATTAAAATTTTCTGTTTTTACAAATTCCAGGGTTGTCTCTTTTTCATGTAATAAGAAAATTAAATTTT
CTGTTCTAGTTTTTTCTGTAATCATAAGCATTCTGATATTTTAAAATCATAAAGATGATGGAAAGTAGATTTATTTTTAAGCCAGGTACG
TAATTTTTTATTTATCATAAAATTTAGTATTTTTGAATATTAAAATTAAGAAGATGACTATAACAAGAATTTTTCTAACATAACATGCTA
TTATTATTTTAGTTATTTTGAAGACATTTCTAGTTTAACTTTCATTTAGCAAACTTCCTATCAAAATAAGAGCATATAAAGACTTAGCGT

>In-frame_ENST00000546373_ENST00000229179_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(amino acids)=80AA_start in transcript=297_stop in transcript=539

--------------------------------------------------------------
>In-frame_ENST00000546373_ENST00000378905_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(transcript)=761nt_BP=264nt
GTCTAGATTCTTCTTGGCCTCTCTGAGCAGCATTTCTTCCTTCTGCGTATGGGACAGGACCCTTTCTGGAATGGGGGTCTTATGACCTAC
AATCAAACAAGAACATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGGTAGCTGCGCTGGATTTCAACTACCACCGCCAGG
AAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACTTACACAGTATTGGGAAATCTGTGAAAGGATGCC
AAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCAC
AGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAG
CTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAG
TTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACC
ATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTATCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGC

>In-frame_ENST00000546373_ENST00000378905_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(amino acids)=80AA_start in transcript=297_stop in transcript=539

--------------------------------------------------------------
>In-frame_ENST00000546373_ENST00000539906_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(transcript)=609nt_BP=264nt
GTCTAGATTCTTCTTGGCCTCTCTGAGCAGCATTTCTTCCTTCTGCGTATGGGACAGGACCCTTTCTGGAATGGGGGTCTTATGACCTAC
AATCAAACAAGAACATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGGTAGCTGCGCTGGATTTCAACTACCACCGCCAGG
AAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACTTACACAGTATTGGGAAATCTGTGAAAGGATGCC
AAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCAC
AGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAG
CTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAG

>In-frame_ENST00000546373_ENST00000539906_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(amino acids)=80AA_start in transcript=297_stop in transcript=539

--------------------------------------------------------------
>In-frame_ENST00000551568_ENST00000229179_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(transcript)=1040nt_BP=221nt
ATAACACCCGGCCCCGCCGGGCGGCCGCGGGTGGGTAGAGGTGCGCGCCTGGGACCTGAACATGGACTTCCCGTGCCTCTGGCTAGGGCT
GTTGCTGCCTTTGGTAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAG
TTCTGTCACTCACTTACACAGTATTGGGAAATCTGTGAAAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAA
AGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGG
TATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGC
TCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTT
TTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATT
ATCGTGACACTTTCAACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAAAATTAAAATTTTCTGTTTTTAC
AAATTCCAGGGTTGTCTCTTTTTCATGTAATAAGAAAATTAAATTTTCTGTTCTAGTTTTTTCTGTAATCATAAGCATTCTGATATTTTA
AAATCATAAAGATGATGGAAAGTAGATTTATTTTTAAGCCAGGTACGTAATTTTTTATTTATCATAAAATTTAGTATTTTTGAATATTAA
AATTAAGAAGATGACTATAACAAGAATTTTTCTAACATAACATGCTATTATTATTTTAGTTATTTTGAAGACATTTCTAGTTTAACTTTC

>In-frame_ENST00000551568_ENST00000229179_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(amino acids)=80AA_start in transcript=254_stop in transcript=496

--------------------------------------------------------------
>In-frame_ENST00000551568_ENST00000378905_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(transcript)=718nt_BP=221nt
ATAACACCCGGCCCCGCCGGGCGGCCGCGGGTGGGTAGAGGTGCGCGCCTGGGACCTGAACATGGACTTCCCGTGCCTCTGGCTAGGGCT
GTTGCTGCCTTTGGTAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAG
TTCTGTCACTCACTTACACAGTATTGGGAAATCTGTGAAAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAA
AGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGG
TATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGC
TCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTT
TTTAATAAAATATACTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATT

>In-frame_ENST00000551568_ENST00000378905_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(amino acids)=80AA_start in transcript=254_stop in transcript=496

--------------------------------------------------------------
>In-frame_ENST00000551568_ENST00000539906_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(transcript)=566nt_BP=221nt
ATAACACCCGGCCCCGCCGGGCGGCCGCGGGTGGGTAGAGGTGCGCGCCTGGGACCTGAACATGGACTTCCCGTGCCTCTGGCTAGGGCT
GTTGCTGCCTTTGGTAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAG
TTCTGTCACTCACTTACACAGTATTGGGAAATCTGTGAAAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAA
AGCTTTGTCTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGG
TATCCTCTGAGCGCCACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGC
TCCTAGACCAGGGACTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTT

>In-frame_ENST00000551568_ENST00000539906_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(amino acids)=80AA_start in transcript=254_stop in transcript=496

--------------------------------------------------------------
>In-frame_ENST00000338356_ENST00000229179_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(transcript)=1026nt_BP=207nt
CCCTCATGTGTTCTCAGGTTCTTCTTATTTTTATTCATCTCTAGAACATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGG
TAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACT
TACACAGTATTGGGAAATCTGTGAAAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCA
ATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGC
CACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGGA
CTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAATAAAATATA
CTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTATCGTGACACTTTC
AACATGTAGGGATATCAGCGTTTCTCTGTGTGCTTGTTAATAAAACTATATAAAAATTAAAATTTTCTGTTTTTACAAATTCCAGGGTTG
TCTCTTTTTCATGTAATAAGAAAATTAAATTTTCTGTTCTAGTTTTTTCTGTAATCATAAGCATTCTGATATTTTAAAATCATAAAGATG
ATGGAAAGTAGATTTATTTTTAAGCCAGGTACGTAATTTTTTATTTATCATAAAATTTAGTATTTTTGAATATTAAAATTAAGAAGATGA
CTATAACAAGAATTTTTCTAACATAACATGCTATTATTATTTTAGTTATTTTGAAGACATTTCTAGTTTAACTTTCATTTAGCAAACTTC

>In-frame_ENST00000338356_ENST00000229179_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(amino acids)=80AA_start in transcript=240_stop in transcript=482

--------------------------------------------------------------
>In-frame_ENST00000338356_ENST00000378905_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(transcript)=704nt_BP=207nt
CCCTCATGTGTTCTCAGGTTCTTCTTATTTTTATTCATCTCTAGAACATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGG
TAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACT
TACACAGTATTGGGAAATCTGTGAAAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCA
ATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGC
CACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGGA
CTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAATAAAATATA
CTTGTTATTAGTAATTTTTTCTTTTGCATTACCATGTAAAATTTAGACATTTGAATTTTGTACTTTTCAGAATATTATCGTGACACTTTC

>In-frame_ENST00000338356_ENST00000378905_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(amino acids)=80AA_start in transcript=240_stop in transcript=482

--------------------------------------------------------------
>In-frame_ENST00000338356_ENST00000539906_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(transcript)=552nt_BP=207nt
CCCTCATGTGTTCTCAGGTTCTTCTTATTTTTATTCATCTCTAGAACATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGG
TAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACT
TACACAGTATTGGGAAATCTGTGAAAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTCTTACTGAGAAAGCTTTGTCTGCCA
ATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAATGCCTACAGTTAGCAGATATGGTATCCTCTGAGCGC
CACAAACTGTACCTGGTATTTTCTAAGGAAGAGCTAAGGAAGTTGCTGCAGAAGCTCAGAGAGTCCTCTCTAATGCTCCTAGACCAGGGA
CTTGACCCATTAGGGTATGAAATTCAGTTATAGTTTAATCTTTGTAATCTCACTAATTTTCATGATAAATGAAGTTTTTAATAAAATATA

>In-frame_ENST00000338356_ENST00000539906_TCGA-06-0174-01A_CPM_chr12_69326458_-_NUP107_chr12_69135593_length(amino acids)=80AA_start in transcript=240_stop in transcript=482

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Fusion Gene PPI Analysis for CPM-NUP107


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CPM-NUP107


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CPM-NUP107


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCPMC0014175Endometriosis1CTD_human
HgeneCPMC0037116Silicosis1CTD_human
HgeneCPMC0269102Endometrioma1CTD_human
TgeneNUP107C4225228NEPHROTIC SYNDROME, TYPE 112CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNUP107C0018051Gonadal Dysgenesis1GENOMICS_ENGLAND
TgeneNUP107C0685837Pure Gonadal Dysgenesis, 46, XX1ORPHANET
TgeneNUP107C0795949Galloway Mowat syndrome1ORPHANET
TgeneNUP107C0949595Gonadal Dysgenesis, 46,XX1ORPHANET
TgeneNUP107C1868672NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE1ORPHANET
TgeneNUP107C4748084OVARIAN DYSGENESIS 61UNIPROT