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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:AAK1-NOP58 (FusionGDB2 ID:193)

Fusion Gene Summary for AAK1-NOP58

Fusion gene summary

Fusion gene information	Fusion gene name: AAK1-NOP58
	Fusion gene ID: 193
		Hgene	Tgene
	Gene symbol	AAK1	NOP58
	Gene ID	112268437	51602
	Gene name	uncharacterized protein FLJ45252	NOP58 ribonucleoprotein
	Synonyms	AAK1	HSPC120\|NOP5\|NOP5/NOP58
	Cytomap	-	2q33.1
	Type of gene	protein-coding	protein-coding
	Description	uncharacterized protein FLJ45252alternative protein AAK1	nucleolar protein 58NOP58 ribonucleoprotein homolognucleolar protein 5nucleolar protein NOP5/NOP58
	Modification date	20200303	20200313
	UniProtAcc	Q2M2I8	Q9Y2X3
	Ensembl transtripts involved in fusion gene	ENST00000409068, ENST00000409085, ENST00000406297, ENST00000470281,	ENST00000264279, ENST00000467734,
Fusion gene scores	* DoF score	19 X 13 X 11=2717	6 X 7 X 3=126
	# samples	22	6
	** MAII score	log2(22/2717*10)=-3.62643913669732 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/126*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: AAK1 [Title/Abstract] AND NOP58 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AAK1(69732700)-NOP58(203160396), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across AAK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NOP58 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-LN-A4A8	AAK1	chr2	69732700	-	NOP58	chr2	203160396	+
ChimerDB4	ESCA	TCGA-LN-A4A8	AAK1	chr2	69732700	-	NOP58	chr2	203160396	+

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Fusion Gene ORF analysis for AAK1-NOP58

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000409068	ENST00000264279	AAK1	chr2	69732700	-	NOP58	chr2	203160396	+
intron-intron	ENST00000409068	ENST00000467734	AAK1	chr2	69732700	-	NOP58	chr2	203160396	+
In-frame	ENST00000409085	ENST00000264279	AAK1	chr2	69732700	-	NOP58	chr2	203160396	+
5CDS-intron	ENST00000409085	ENST00000467734	AAK1	chr2	69732700	-	NOP58	chr2	203160396	+
In-frame	ENST00000406297	ENST00000264279	AAK1	chr2	69732700	-	NOP58	chr2	203160396	+
5CDS-intron	ENST00000406297	ENST00000467734	AAK1	chr2	69732700	-	NOP58	chr2	203160396	+
intron-3CDS	ENST00000470281	ENST00000264279	AAK1	chr2	69732700	-	NOP58	chr2	203160396	+
intron-intron	ENST00000470281	ENST00000467734	AAK1	chr2	69732700	-	NOP58	chr2	203160396	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000409085

AAK1

chr2

69732700

ENST00000264279

NOP58

chr2

203160396

3559

2646

278

3328

1016

ENST00000406297

AAK1

chr2

69732700

ENST00000264279

NOP58

chr2

203160396

3559

2646

278

3328

1016

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000409085	ENST00000264279	AAK1	chr2	69732700	-	NOP58	chr2	203160396	+	0.005306801	0.9946932
ENST00000406297	ENST00000264279	AAK1	chr2	69732700	-	NOP58	chr2	203160396	+	0.005306801	0.9946932

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Fusion Genomic Features for AAK1-NOP58

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
AAK1	chr2	69732700	-	NOP58	chr2	203160396	+	1.73E-08	1
AAK1	chr2	69732700	-	NOP58	chr2	203160396	+	1.73E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for AAK1-NOP58

Go to
FGviewer for the breakpoints of chr2:69732700-chr2:203160396
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
AAK1 Q2M2I8	NOP58 Q9Y2X3
FUNCTION: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis (PubMed:17494869, PubMed:11877457, PubMed:11877461, PubMed:12952931, PubMed:14617351, PubMed:25653444). Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1 (PubMed:17494869). Preferentially, may phosphorylate substrates on threonine residues (PubMed:11877457, PubMed:18657069). Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes (PubMed:12952931). Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes (PubMed:18657069). Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity (PubMed:21464124). {ECO:0000269\|PubMed:11877457, ECO:0000269\|PubMed:11877461, ECO:0000269\|PubMed:12952931, ECO:0000269\|PubMed:14617351, ECO:0000269\|PubMed:17494869, ECO:0000269\|PubMed:18657069, ECO:0000269\|PubMed:21464124, ECO:0000269\|PubMed:25653444}.; FUNCTION: (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue. {ECO:0000269\|PubMed:25653444, ECO:0000305\|PubMed:31136173}.	FUNCTION: Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. {ECO:0000250, ECO:0000269\|PubMed:15574333, ECO:0000269\|PubMed:17636026, ECO:0000269\|PubMed:19620283}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AAK1

chr2:69732700

chr2:203160396

ENST00000406297

12_42

756.3333333333334

864.0

Compositional bias

Note=Gly-rich

Hgene

AAK1

chr2:69732700

chr2:203160396

ENST00000406297

397_614

756.3333333333334

864.0

Compositional bias

Note=Gln-rich

Hgene

AAK1

chr2:69732700

chr2:203160396

ENST00000406297

658_663

756.3333333333334

864.0

Compositional bias

Note=Poly-Ala

Hgene

AAK1

chr2:69732700

chr2:203160396

ENST00000409085

12_42

756.3333333333334

962.0

Compositional bias

Note=Gly-rich

Hgene

AAK1

chr2:69732700

chr2:203160396

ENST00000409085

397_614

756.3333333333334

962.0

Compositional bias

Note=Gln-rich

Hgene

AAK1

chr2:69732700

chr2:203160396

ENST00000409085

658_663

756.3333333333334

962.0

Compositional bias

Note=Poly-Ala

Hgene

AAK1

chr2:69732700

chr2:203160396

ENST00000406297

46_315

756.3333333333334

864.0

Domain

Protein kinase

Hgene

AAK1

chr2:69732700

chr2:203160396

ENST00000409085

46_315

756.3333333333334

962.0

Domain

Protein kinase

Hgene

AAK1

chr2:69732700

chr2:203160396

ENST00000406297

52_60

756.3333333333334

864.0

Nucleotide binding

ATP

Hgene

AAK1

chr2:69732700

chr2:203160396

ENST00000409085

52_60

756.3333333333334

962.0

Nucleotide binding

ATP

Tgene

NOP58

chr2:69732700

chr2:203160396

ENST00000264279

441_524

302.3333333333333

530.0

Compositional bias

Note=Lys-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AAK1

chr2:69732700

chr2:203160396

ENST00000406297

823_960

756.3333333333334

864.0

Region

Clathrin-binding domain (CBD)

Hgene

AAK1

chr2:69732700

chr2:203160396

ENST00000409085

823_960

756.3333333333334

962.0

Region

Clathrin-binding domain (CBD)

Tgene

NOP58

chr2:69732700

chr2:203160396

ENST00000264279

282_400

302.3333333333333

530.0

Domain

Nop

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Fusion Gene Sequence for AAK1-NOP58

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000409085_ENST00000264279_TCGA-LN-A4A8_AAK1_chr2_69732700_-_NOP58_chr2_203160396_length(transcript)=3559nt_BP=2646nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCC
AGGTGTGCAAGAGAGAAATCCAGATAATGAGGGATCTTTCAGGGCACAAGAATATTGTGGGTTACATTGATTCTAGTATCAACAACGTGA
GTAGCGGTGATGTATGGGAAGTGCTCATTCTGATGGACTTTTGTAGAGGTGGCCAGGTGGTAAACCTGATGAACCAGCGCCTGCAAACAG
GCTTTACAGAGAATGAAGTGCTCCAGATATTTTGTGATACCTGTGAAGCTGTTGCCCGCCTGCATCAGTGCAAAACTCCTATTATCCACC
GGGACCTGAAGGTTGAAAACATCCTCTTGCATGACCGAGGCCACTATGTCCTGTGTGACTTTGGAAGCGCCACCAACAAATTCCAGAATC
CACAAACTGAGGGAGTCAATGCAGTAGAAGATGAGATTAAGAAATACACAACGCTGTCCTATCGAGCACCAGAAATGGTCAACCTGTACA
GTGGCAAAATCATCACTACGAAGGCAGACATTTGGGCTCTTGGATGTTTGTTGTATAAATTATGCTACTTCACTTTGCCATTTGGGGAAA
GTCAGGTGGCAATTTGTGATGGAAACTTCACAATTCCTGATAATTCTCGATATTCTCAAGACATGCACTGCCTAATTAGGTATATGTTGG
AACCAGACCCTGACAAAAGGCCGGATATTTACCAGGTGTCCTACTTCTCATTTAAGCTACTCAAGAAAGAGTGCCCAATTCCAAATGTAC
AGAACTCTCCCATTCCTGCAAAGCTTCCTGAACCAGTGAAAGCCAGTGAGGCAGCTGCAAAAAAGACCCAGCCAAAGGCCAGACTGACAG
ATCCCATTCCCACCACAGAGACTTCAATTGCACCCCGCCAGAGGCCTAAAGCTGGGCAGACTCAGCCGAACCCAGGAATCCTTCCCATCC
AGCCAGCGCTGACACCCCGGAAGAGGGCCACTGTTCAGCCCCCACCTCAGGCTGCAGGATCCAGCAATCAGCCTGGCCTTTTAGCCAGTG
TTCCCCAACCAAAACCCCAAGCCCCACCCAGCCAGCCTCTGCCGCAAACTCAGGCCAAGCAGCCACAGGCTCCTCCCACTCCACAGCAGA
CGCCTTCTACTCAGGCCCAGGGTCTGCCCGCTCAGGCCCAGGCCACACCCCAGCACCAGCAGCAACTCTTCCTCAAGCAGCAACAGCAGC
AGCAACAGCCACCGCCAGCACAGCAGCAGCCGGCAGGCACGTTTTACCAGCAGCAGCAGGCCCAGACTCAGCAGTTTCAGGCAGTACATC
CAGCAACCCAGAAACCAGCAATTGCTCAGTTCCCTGTGGTGTCCCAAGGAGGCTCTCAACAGCAGCTAATGCAGAATTTCTACCAGCAGC
AGCAGCAGCAGCAACAACAACAGCAACAGCAACAGCTGGCCACAGCCCTGCATCAACAACAGCTGATGACTCAGCAGGCTGCCTTGCAGC
AAAAGCCCACTATGGCAGCAGGACAGCAGCCCCAGCCACAGCCAGCTGCAGCCCCACAGCCAGCCCCTGCCCAGGAGCCAGCGATTCAAG
CCCCAGTAAGACAACAGCCAAAGGTTCAGACAACCCCACCTCCTGCCGTCCAGGGGCAGAAAGTTGGATCTCTCACTCCACCCTCATCCC
CCAAAACCCAACGTGCTGGGCACAGGCGTATTCTCAGTGACGTAACCCACAGTGCAGTCTTTGGGGTCCCTGCCAGCAAATCAACCCAGC
TGCTCCAGGCAGCTGCAGCTGAGGCCAGTCTCAATAAGTCCAAGTCTGCAACCACCACTCCATCAGGCTCTCCTCGGACCTCTCAACAAA
ACGTTTATAATCCTTCAGAAGGGTCTACGTGGAATCCCTTTGATGACGATAATTTCTCCAAACTCACAGCTGAAGAACTGCTAAACAAGG
ACTTTGCCAAGCTTGGGGAAGGCAAACATCCCGAGAAGCTTGGAGGCTCAGCTGAGAGTTTGATCCCAGGCTTTCAATCAACCCAAGGTG
ATGCTTTTGCTACGACCTCATTTTCTGCTGGAACTGGTTCTCTTTTAAATTTGGCCAAGCATGCAGCTTCTACCGTTCAGATTCTTGGAG
CTGAAAAGGCACTTTTCAGAGCCCTCAAATCTAGACGGGATACCCCTAAGTATGGTCTCATTTATCATGCTTCACTCGTGGGCCAGACAA
GTCCCAAACACAAAGGAAAGATTTCTCGAATGCTGGCAGCCAAAACCGTTTTGGCTATCCGTTATGATGCTTTTGGTGAGGATTCAAGTT
CTGCAATGGGAGTTGAGAACAGAGCCAAATTAGAGGCCAGGTTGAGAACTTTGGAAGACAGAGGGATAAGAAAAATAAGTGGAACAGGAA
AAGCATTAGCAAAAACAGAAAAATATGAACACAAAAGTGAAGTGAAGACTTACGATCCTTCTGGTGACTCCACACTTCCAACCTGTTCTA
AAAAACGCAAAATAGAACAGGTAGATAAAGAGGATGAAATTACTGAAAAGAAAGCCAAAAAAGCCAAGATTAAAGTTAAAGTTGAAGAAG
AGGAAGAAGAAAAAGTGGCAGAAGAAGAAGAAACATCTGTGAAGAAGAAGAAGAAAAGGGGTAAAAAGAAACACATTAAGGAAGAACCAC
TTTCTGAGGAAGAACCATGTACCAGCACAGCAATTGCTAGTCCAGAGAAAAAGAAGAAAAAGAAAAAAAAGAGAGAGAACGAGGATTAAC
AGAAAGGAATTACGATTATATCACCCGGACACACATCATGCTTAAGATTCAACTGGGAGCATACCAGGGATGCTCTCTAACGTAATCAAG
GGAAGGTTCAGTAAGACAAAGTGATTTATCATCTATAACTTCAAACCTATTTGTCTTGACATCAACTCTGTTAACCTTATGTCATCATTT

>In-frame_ENST00000409085_ENST00000264279_TCGA-LN-A4A8_AAK1_chr2_69732700_-_NOP58_chr2_203160396_length(amino acids)=1016AA_start in transcript=278_stop in transcript=3328
MRRNPWISFLKKKKKKKKSRNHRYFALLLPIRKMKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGF
AIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFT
ENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGK
IITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNS
PIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQ
PKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPAT
QKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPV
RQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVY
NPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTGSLLNLAKHAASTVQILGAEK
ALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKAL
AKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSE

--------------------------------------------------------------
>In-frame_ENST00000406297_ENST00000264279_TCGA-LN-A4A8_AAK1_chr2_69732700_-_NOP58_chr2_203160396_length(transcript)=3559nt_BP=2646nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCC
AGGTGTGCAAGAGAGAAATCCAGATAATGAGGGATCTTTCAGGGCACAAGAATATTGTGGGTTACATTGATTCTAGTATCAACAACGTGA
GTAGCGGTGATGTATGGGAAGTGCTCATTCTGATGGACTTTTGTAGAGGTGGCCAGGTGGTAAACCTGATGAACCAGCGCCTGCAAACAG
GCTTTACAGAGAATGAAGTGCTCCAGATATTTTGTGATACCTGTGAAGCTGTTGCCCGCCTGCATCAGTGCAAAACTCCTATTATCCACC
GGGACCTGAAGGTTGAAAACATCCTCTTGCATGACCGAGGCCACTATGTCCTGTGTGACTTTGGAAGCGCCACCAACAAATTCCAGAATC
CACAAACTGAGGGAGTCAATGCAGTAGAAGATGAGATTAAGAAATACACAACGCTGTCCTATCGAGCACCAGAAATGGTCAACCTGTACA
GTGGCAAAATCATCACTACGAAGGCAGACATTTGGGCTCTTGGATGTTTGTTGTATAAATTATGCTACTTCACTTTGCCATTTGGGGAAA
GTCAGGTGGCAATTTGTGATGGAAACTTCACAATTCCTGATAATTCTCGATATTCTCAAGACATGCACTGCCTAATTAGGTATATGTTGG
AACCAGACCCTGACAAAAGGCCGGATATTTACCAGGTGTCCTACTTCTCATTTAAGCTACTCAAGAAAGAGTGCCCAATTCCAAATGTAC
AGAACTCTCCCATTCCTGCAAAGCTTCCTGAACCAGTGAAAGCCAGTGAGGCAGCTGCAAAAAAGACCCAGCCAAAGGCCAGACTGACAG
ATCCCATTCCCACCACAGAGACTTCAATTGCACCCCGCCAGAGGCCTAAAGCTGGGCAGACTCAGCCGAACCCAGGAATCCTTCCCATCC
AGCCAGCGCTGACACCCCGGAAGAGGGCCACTGTTCAGCCCCCACCTCAGGCTGCAGGATCCAGCAATCAGCCTGGCCTTTTAGCCAGTG
TTCCCCAACCAAAACCCCAAGCCCCACCCAGCCAGCCTCTGCCGCAAACTCAGGCCAAGCAGCCACAGGCTCCTCCCACTCCACAGCAGA
CGCCTTCTACTCAGGCCCAGGGTCTGCCCGCTCAGGCCCAGGCCACACCCCAGCACCAGCAGCAACTCTTCCTCAAGCAGCAACAGCAGC
AGCAACAGCCACCGCCAGCACAGCAGCAGCCGGCAGGCACGTTTTACCAGCAGCAGCAGGCCCAGACTCAGCAGTTTCAGGCAGTACATC
CAGCAACCCAGAAACCAGCAATTGCTCAGTTCCCTGTGGTGTCCCAAGGAGGCTCTCAACAGCAGCTAATGCAGAATTTCTACCAGCAGC
AGCAGCAGCAGCAACAACAACAGCAACAGCAACAGCTGGCCACAGCCCTGCATCAACAACAGCTGATGACTCAGCAGGCTGCCTTGCAGC
AAAAGCCCACTATGGCAGCAGGACAGCAGCCCCAGCCACAGCCAGCTGCAGCCCCACAGCCAGCCCCTGCCCAGGAGCCAGCGATTCAAG
CCCCAGTAAGACAACAGCCAAAGGTTCAGACAACCCCACCTCCTGCCGTCCAGGGGCAGAAAGTTGGATCTCTCACTCCACCCTCATCCC
CCAAAACCCAACGTGCTGGGCACAGGCGTATTCTCAGTGACGTAACCCACAGTGCAGTCTTTGGGGTCCCTGCCAGCAAATCAACCCAGC
TGCTCCAGGCAGCTGCAGCTGAGGCCAGTCTCAATAAGTCCAAGTCTGCAACCACCACTCCATCAGGCTCTCCTCGGACCTCTCAACAAA
ACGTTTATAATCCTTCAGAAGGGTCTACGTGGAATCCCTTTGATGACGATAATTTCTCCAAACTCACAGCTGAAGAACTGCTAAACAAGG
ACTTTGCCAAGCTTGGGGAAGGCAAACATCCCGAGAAGCTTGGAGGCTCAGCTGAGAGTTTGATCCCAGGCTTTCAATCAACCCAAGGTG
ATGCTTTTGCTACGACCTCATTTTCTGCTGGAACTGGTTCTCTTTTAAATTTGGCCAAGCATGCAGCTTCTACCGTTCAGATTCTTGGAG
CTGAAAAGGCACTTTTCAGAGCCCTCAAATCTAGACGGGATACCCCTAAGTATGGTCTCATTTATCATGCTTCACTCGTGGGCCAGACAA
GTCCCAAACACAAAGGAAAGATTTCTCGAATGCTGGCAGCCAAAACCGTTTTGGCTATCCGTTATGATGCTTTTGGTGAGGATTCAAGTT
CTGCAATGGGAGTTGAGAACAGAGCCAAATTAGAGGCCAGGTTGAGAACTTTGGAAGACAGAGGGATAAGAAAAATAAGTGGAACAGGAA
AAGCATTAGCAAAAACAGAAAAATATGAACACAAAAGTGAAGTGAAGACTTACGATCCTTCTGGTGACTCCACACTTCCAACCTGTTCTA
AAAAACGCAAAATAGAACAGGTAGATAAAGAGGATGAAATTACTGAAAAGAAAGCCAAAAAAGCCAAGATTAAAGTTAAAGTTGAAGAAG
AGGAAGAAGAAAAAGTGGCAGAAGAAGAAGAAACATCTGTGAAGAAGAAGAAGAAAAGGGGTAAAAAGAAACACATTAAGGAAGAACCAC
TTTCTGAGGAAGAACCATGTACCAGCACAGCAATTGCTAGTCCAGAGAAAAAGAAGAAAAAGAAAAAAAAGAGAGAGAACGAGGATTAAC
AGAAAGGAATTACGATTATATCACCCGGACACACATCATGCTTAAGATTCAACTGGGAGCATACCAGGGATGCTCTCTAACGTAATCAAG
GGAAGGTTCAGTAAGACAAAGTGATTTATCATCTATAACTTCAAACCTATTTGTCTTGACATCAACTCTGTTAACCTTATGTCATCATTT

>In-frame_ENST00000406297_ENST00000264279_TCGA-LN-A4A8_AAK1_chr2_69732700_-_NOP58_chr2_203160396_length(amino acids)=1016AA_start in transcript=278_stop in transcript=3328
MRRNPWISFLKKKKKKKKSRNHRYFALLLPIRKMKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGF
AIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFT
ENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGK
IITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNS
PIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQ
PKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPAT
QKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPV
RQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVY
NPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTGSLLNLAKHAASTVQILGAEK
ALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKAL
AKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSE

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Fusion Gene PPI Analysis for AAK1-NOP58

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for AAK1-NOP58

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	AAK1	Q2M2I8	DB12010	Fostamatinib	Inhibitor	Small molecule	Approved\|Investigational
Hgene	AAK1	Q2M2I8	DB12010	Fostamatinib	Inhibitor	Small molecule	Approved\|Investigational

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Related Diseases for AAK1-NOP58

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	NOP58	C0152013	Adenocarcinoma of lung (disorder)	1	CTD_human