FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CREBBP-TRAP1 (FusionGDB2 ID:19394)

Fusion Gene Summary for CREBBP-TRAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CREBBP-TRAP1
Fusion gene ID: 19394
HgeneTgene
Gene symbol

CREBBP

TRAP1

Gene ID

1387

10131

Gene nameCREB binding proteinTNF receptor associated protein 1
SynonymsCBP|KAT3A|MKHK1|RSTS|RSTS1HSP 75|HSP75|HSP90L|TRAP-1
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionCREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBPheat shock protein 75 kDa, mitochondrialTNFR-associated protein 1testicular tissue protein Li 209tumor necrosis factor type 1 receptor-associated protein
Modification date2020032920200313
UniProtAcc

Q92793

.
Ensembl transtripts involved in fusion geneENST00000262367, ENST00000382070, 
ENST00000246957, ENST00000575671, 
ENST00000538171, ENST00000573872, 
Fusion gene scores* DoF score43 X 38 X 17=277787 X 10 X 7=490
# samples 6112
** MAII scorelog2(61/27778*10)=-5.50898967694577
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/490*10)=-2.02974734339405
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CREBBP [Title/Abstract] AND TRAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCREBBP(3929833)-TRAP1(3740986), # samples:5
TRAP1(3740828)-CREBBP(3799684), # samples:1
Anticipated loss of major functional domain due to fusion event.CREBBP-TRAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CREBBP-TRAP1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CREBBP-TRAP1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CREBBP-TRAP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CREBBP-TRAP1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CREBBP-TRAP1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TRAP1-CREBBP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TRAP1-CREBBP seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TRAP1-CREBBP seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
TRAP1-CREBBP seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TRAP1-CREBBP seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TRAP1-CREBBP seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCREBBP

GO:0000122

negative regulation of transcription by RNA polymerase II

21539536

HgeneCREBBP

GO:0006355

regulation of transcription, DNA-templated

12169688

HgeneCREBBP

GO:0006473

protein acetylation

15273251|24207024|24939902|28790157|30540930

HgeneCREBBP

GO:0016573

histone acetylation

11742995

HgeneCREBBP

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

HgeneCREBBP

GO:0034644

cellular response to UV

24939902

HgeneCREBBP

GO:0045893

positive regulation of transcription, DNA-templated

11742995

HgeneCREBBP

GO:1990258

histone glutamine methylation

30540930


check buttonFusion gene breakpoints across CREBBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TRAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GV-A3QI-01ACREBBPchr16

3841982

-TRAP1chr16

3740986

-
ChimerDB4BRCATCGA-AR-A1AR-01ACREBBPchr16

3929833

-TRAP1chr16

3740986

-
ChimerDB4BRCATCGA-B6-A0RE-01ACREBBPchr16

3817721

-TRAP1chr16

3716119

-
ChimerDB4ESCATCGA-LN-A49SCREBBPchr16

3929833

-TRAP1chr16

3739138

-
ChimerDB4HNSCTCGA-CV-6948CREBBPchr16

3860604

-TRAP1chr16

3740986

-
ChimerDB4LUSCTCGA-33-4582CREBBPchr16

3929833

-TRAP1chr16

3740986

-
ChimerDB4OVTCGA-24-2288-01ACREBBPchr16

3929833

-TRAP1chr16

3740986

-
ChimerDB4OVTCGA-31-1959-01ACREBBPchr16

3929833

-TRAP1chr16

3740986

-
ChimerDB4STADTCGA-CG-4441-01ACREBBPchr16

3900298

-TRAP1chr16

3740986

-
ChimerDB4STADTCGA-VQ-A8P3-01ACREBBPchr16

3929833

-TRAP1chr16

3740986

-
ChimerDB4STADTCGA-VQ-A928-01ACREBBPchr16

3841982

-TRAP1chr16

3740986

-
ChimerDB4BLCATCGA-GV-A3QI-01ACREBBPchr16

3841981

-TRAP1chr16

3740985

-


Top

Fusion Gene ORF analysis for CREBBP-TRAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262367ENST00000246957CREBBPchr16

3841982

-TRAP1chr16

3740986

-
5CDS-intronENST00000262367ENST00000575671CREBBPchr16

3841982

-TRAP1chr16

3740986

-
5CDS-intronENST00000262367ENST00000538171CREBBPchr16

3841982

-TRAP1chr16

3740986

-
5CDS-intronENST00000262367ENST00000573872CREBBPchr16

3841982

-TRAP1chr16

3740986

-
intron-3CDSENST00000382070ENST00000246957CREBBPchr16

3841982

-TRAP1chr16

3740986

-
intron-intronENST00000382070ENST00000575671CREBBPchr16

3841982

-TRAP1chr16

3740986

-
intron-intronENST00000382070ENST00000538171CREBBPchr16

3841982

-TRAP1chr16

3740986

-
intron-intronENST00000382070ENST00000573872CREBBPchr16

3841982

-TRAP1chr16

3740986

-
Frame-shiftENST00000262367ENST00000246957CREBBPchr16

3929833

-TRAP1chr16

3740986

-
5CDS-intronENST00000262367ENST00000575671CREBBPchr16

3929833

-TRAP1chr16

3740986

-
5CDS-intronENST00000262367ENST00000538171CREBBPchr16

3929833

-TRAP1chr16

3740986

-
5CDS-intronENST00000262367ENST00000573872CREBBPchr16

3929833

-TRAP1chr16

3740986

-
Frame-shiftENST00000382070ENST00000246957CREBBPchr16

3929833

-TRAP1chr16

3740986

-
5CDS-intronENST00000382070ENST00000575671CREBBPchr16

3929833

-TRAP1chr16

3740986

-
5CDS-intronENST00000382070ENST00000538171CREBBPchr16

3929833

-TRAP1chr16

3740986

-
5CDS-intronENST00000382070ENST00000573872CREBBPchr16

3929833

-TRAP1chr16

3740986

-
Frame-shiftENST00000262367ENST00000246957CREBBPchr16

3817721

-TRAP1chr16

3716119

-
Frame-shiftENST00000262367ENST00000575671CREBBPchr16

3817721

-TRAP1chr16

3716119

-
Frame-shiftENST00000262367ENST00000538171CREBBPchr16

3817721

-TRAP1chr16

3716119

-
5CDS-5UTRENST00000262367ENST00000573872CREBBPchr16

3817721

-TRAP1chr16

3716119

-
Frame-shiftENST00000382070ENST00000246957CREBBPchr16

3817721

-TRAP1chr16

3716119

-
Frame-shiftENST00000382070ENST00000575671CREBBPchr16

3817721

-TRAP1chr16

3716119

-
Frame-shiftENST00000382070ENST00000538171CREBBPchr16

3817721

-TRAP1chr16

3716119

-
5CDS-5UTRENST00000382070ENST00000573872CREBBPchr16

3817721

-TRAP1chr16

3716119

-
Frame-shiftENST00000262367ENST00000246957CREBBPchr16

3929833

-TRAP1chr16

3739138

-
5CDS-intronENST00000262367ENST00000575671CREBBPchr16

3929833

-TRAP1chr16

3739138

-
5CDS-intronENST00000262367ENST00000538171CREBBPchr16

3929833

-TRAP1chr16

3739138

-
5CDS-intronENST00000262367ENST00000573872CREBBPchr16

3929833

-TRAP1chr16

3739138

-
Frame-shiftENST00000382070ENST00000246957CREBBPchr16

3929833

-TRAP1chr16

3739138

-
5CDS-intronENST00000382070ENST00000575671CREBBPchr16

3929833

-TRAP1chr16

3739138

-
5CDS-intronENST00000382070ENST00000538171CREBBPchr16

3929833

-TRAP1chr16

3739138

-
5CDS-intronENST00000382070ENST00000573872CREBBPchr16

3929833

-TRAP1chr16

3739138

-
Frame-shiftENST00000262367ENST00000246957CREBBPchr16

3860604

-TRAP1chr16

3740986

-
5CDS-intronENST00000262367ENST00000575671CREBBPchr16

3860604

-TRAP1chr16

3740986

-
5CDS-intronENST00000262367ENST00000538171CREBBPchr16

3860604

-TRAP1chr16

3740986

-
5CDS-intronENST00000262367ENST00000573872CREBBPchr16

3860604

-TRAP1chr16

3740986

-
Frame-shiftENST00000382070ENST00000246957CREBBPchr16

3860604

-TRAP1chr16

3740986

-
5CDS-intronENST00000382070ENST00000575671CREBBPchr16

3860604

-TRAP1chr16

3740986

-
5CDS-intronENST00000382070ENST00000538171CREBBPchr16

3860604

-TRAP1chr16

3740986

-
5CDS-intronENST00000382070ENST00000573872CREBBPchr16

3860604

-TRAP1chr16

3740986

-
Frame-shiftENST00000262367ENST00000246957CREBBPchr16

3900298

-TRAP1chr16

3740986

-
5CDS-intronENST00000262367ENST00000575671CREBBPchr16

3900298

-TRAP1chr16

3740986

-
5CDS-intronENST00000262367ENST00000538171CREBBPchr16

3900298

-TRAP1chr16

3740986

-
5CDS-intronENST00000262367ENST00000573872CREBBPchr16

3900298

-TRAP1chr16

3740986

-
Frame-shiftENST00000382070ENST00000246957CREBBPchr16

3900298

-TRAP1chr16

3740986

-
5CDS-intronENST00000382070ENST00000575671CREBBPchr16

3900298

-TRAP1chr16

3740986

-
5CDS-intronENST00000382070ENST00000538171CREBBPchr16

3900298

-TRAP1chr16

3740986

-
5CDS-intronENST00000382070ENST00000573872CREBBPchr16

3900298

-TRAP1chr16

3740986

-
In-frameENST00000262367ENST00000246957CREBBPchr16

3841981

-TRAP1chr16

3740985

-
5CDS-intronENST00000262367ENST00000575671CREBBPchr16

3841981

-TRAP1chr16

3740985

-
5CDS-intronENST00000262367ENST00000538171CREBBPchr16

3841981

-TRAP1chr16

3740985

-
5CDS-intronENST00000262367ENST00000573872CREBBPchr16

3841981

-TRAP1chr16

3740985

-
intron-3CDSENST00000382070ENST00000246957CREBBPchr16

3841981

-TRAP1chr16

3740985

-
intron-intronENST00000382070ENST00000575671CREBBPchr16

3841981

-TRAP1chr16

3740985

-
intron-intronENST00000382070ENST00000538171CREBBPchr16

3841981

-TRAP1chr16

3740985

-
intron-intronENST00000382070ENST00000573872CREBBPchr16

3841981

-TRAP1chr16

3740985

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262367CREBBPchr163841982-ENST00000246957TRAP1chr163740986-4259214060641661186
ENST00000262367CREBBPchr163841981-ENST00000246957TRAP1chr163740985-4259214060641661186

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262367ENST00000246957CREBBPchr163841982-TRAP1chr163740986-0.0080692520.9919308
ENST00000262367ENST00000246957CREBBPchr163841981-TRAP1chr163740985-0.0080692520.9919308

Top

Fusion Genomic Features for CREBBP-TRAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CREBBP-TRAP1


check button Go to

FGviewer for the breakpoints of chr16:3841982-chr16:3740986

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CREBBP

Q92793

.
FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:9707565}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-531347_433443.33333333333332443.0Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-531347_433443.33333333333332443.0Zinc fingerTAZ-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311061_1064443.33333333333332443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311199_1487443.33333333333332443.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311555_1562443.33333333333332443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311943_1948443.33333333333332443.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311967_1970443.33333333333332443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5312081_2085443.33333333333332443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5312199_2216443.33333333333332443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5312245_2248443.33333333333332443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5312297_2300443.33333333333332443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301061_106402405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301199_148702405.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301555_156202405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301943_194802405.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301967_197002405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1302081_208502405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1302199_221602405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1302245_224802405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1302297_230002405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311061_1064443.33333333333332443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311199_1487443.33333333333332443.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311555_1562443.33333333333332443.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311943_1948443.33333333333332443.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311967_1970443.33333333333332443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5312081_2085443.33333333333332443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5312199_2216443.33333333333332443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5312245_2248443.33333333333332443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5312297_2300443.33333333333332443.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301061_106402405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301199_148702405.0Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301555_156202405.0Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301943_194802405.0Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301967_197002405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1302081_208502405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1302199_221602405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1302245_224802405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1302297_230002405.0Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311103_1175443.33333333333332443.0DomainBromo
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311323_1700443.33333333333332443.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-531587_666443.33333333333332443.0DomainKIX
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301103_117502405.0DomainBromo
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301323_170002405.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-130587_66602405.0DomainKIX
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311103_1175443.33333333333332443.0DomainBromo
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311323_1700443.33333333333332443.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-531587_666443.33333333333332443.0DomainKIX
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301103_117502405.0DomainBromo
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301323_170002405.0DomainCBP/p300-type HAT
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-130587_66602405.0DomainKIX
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311434_1436443.33333333333332443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311446_1447443.33333333333332443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301434_143602405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301446_144702405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311434_1436443.33333333333332443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311446_1447443.33333333333332443.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301434_143602405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301446_144702405.0RegionAcetyl-CoA binding
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311701_1744443.33333333333332443.0Zinc fingerZZ-type
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311765_1846443.33333333333332443.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301701_174402405.0Zinc fingerZZ-type
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301765_184602405.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-130347_43302405.0Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311701_1744443.33333333333332443.0Zinc fingerZZ-type
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311765_1846443.33333333333332443.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301701_174402405.0Zinc fingerZZ-type
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301765_184602405.0Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-130347_43302405.0Zinc fingerTAZ-type 1


Top

Fusion Gene Sequence for CREBBP-TRAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000262367_ENST00000246957_TCGA-GV-A3QI-01A_CREBBP_chr16_3841982_-_TRAP1_chr16_3740986_length(transcript)=4259nt_BP=2140nt
TTCTTTTTTTTTTAATTGAGGAATCAACAGCCGCCATCTTGTCGCGGACCCGACCGGGGCTTCGAGCGCGATCTACTCGGCCCCGCCGGT
CCCGGGCCCCACAACCGCCCGCGCACCCCGCTCCGCCCGGCCGGCCCGCTCCGCCCGGCCCTCGGCGCCCGCCCCGGCGGCCCCGCTCGC
CTCTCGGCTCGGCCTCCCGGAGCCCGGCGGCGGCGGCGGCGGCAGCGGCGGCGGCGGCGGCGGAACGGGGGGTGGGGGGGCCGCGGCGGC
GGCGGCGACCCCGCTCGGCGCATTGTTTTTCCTCACGGCGGCGGCGGCGGCGGGCCGCGGGCCGGGAGCGGAGCCCGGAGCCCCCTCGTC
GTCGGGCCGCGAGCGAATTCATTAAGTGGGGCGCGGGGGGGGAGCGAGGCGGCGGCGGCGGCGGCACCATGTTCTCGGGGACTGCCTGAG
CCGCCCGGCCGGGCGCCGTCGCTGCCAGCCGGGCCCGGGGGGGCGGCCGGGCCGCCGGGGCGCCCCCACCGCGGAGTGTCGCGCTCGGGA
GGCGGGCAGGGGATGAGGGGGCCGCGGCCGGCGGCGGCGGCGGCGGCCGGGGGCGGGCGGTGAGCGCTGCGGGGCGCTGTTGCTGTGGCT
GAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCGCTCGCGGCCCGCGCTCGCTCCTCT
CCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGGGGCTGTTTTCGCGAGCAGGTGAAA
ATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTCTCGGCGAATGACAGCACAGATTTT
GGATCATTGTTTGACTTGGAAAATGATCTTCCTGATGAGCTGATACCCAATGGAGGAGAATTAGGCCTTTTAAACAGTGGGAACCTTGTT
CCAGATGCTGCTTCCAAACATAAACAACTGTCGGAGCTTCTACGAGGAGGCAGCGGCTCTAGTATCAACCCAGGAATAGGAAATGTGAGC
GCCAGCAGCCCCGTGCAGCAGGGCCTGGGTGGCCAGGCTCAAGGGCAGCCGAACAGTGCTAACATGGCCAGCCTCAGTGCCATGGGCAAG
AGCCCTCTGAGCCAGGGAGATTCTTCAGCCCCCAGCCTGCCTAAACAGGCAGCCAGCACCTCTGGGCCCACCCCCGCTGCCTCCCAAGCA
CTGAATCCGCAAGCACAAAAGCAAGTGGGGCTGGCGACTAGCAGCCCTGCCACGTCACAGACTGGACCTGGTATCTGCATGAATGCTAAC
TTTAACCAGACCCACCCAGGCCTCCTCAATAGTAACTCTGGCCATAGCTTAATTAATCAGGCTTCACAAGGGCAGGCGCAAGTCATGAAT
GGATCTCTTGGGGCTGCTGGCAGAGGAAGGGGAGCTGGAATGCCGTACCCTACTCCAGCCATGCAGGGCGCCTCGAGCAGCGTGCTGGCT
GAGACCCTAACGCAGGTTTCCCCGCAAATGACTGGTCACGCGGGACTGAACACCGCACAGGCAGGAGGCATGGCCAAGATGGGAATAACT
GGGAACACAAGTCCATTTGGACAGCCCTTTAGTCAAGCTGGAGGGCAGCCAATGGGAGCCACTGGAGTGAACCCCCAGTTAGCCAGCAAA
CAGAGCATGGTCAACAGTTTGCCCACCTTCCCTACAGATATCAAGAATACTTCAGTCACCAACGTGCCAAATATGTCTCAGATGCAAACA
TCAGTGGGAATTGTACCCACACAAGCAATTGCAACAGGCCCCACTGCAGATCCTGAAAAACGCAAACTGATACAGCAGCAGCTGGTTCTA
CTGCTTCATGCTCATAAGTGTCAGAGACGAGAGCAAGCAAACGGAGAGGTTCGGGCCTGCTCGCTCCCGCATTGTCGAACCATGAAAAAC
GTTTTGAATCACATGACGCATTGTCAGGCTGGGAAAGCCTGCCAAGTTGCCCATTGTGCATCTTCACGACAAATCATCTCTCATTGGAAG
AACTGCACACGACATGACTGTCCTGTTTGCCTCCCTTTGAAAAATGCCAGTGACAAGCGAAACCAACAAAGAAAACCAATTCTGTGTCCT
CGGAGGACCACAGCCCAGTTGGGCCCCAGGCGAAACCCAGCCTGGAGCTTGCAGGCAGGACGACTGTTCAGCACGCAGACCGCCGAGGAC
AAGGAGGAACCCCTGCACTCGATTATCAGCAGCACAGAGAGCGTGCAGGGTTCCACTTCCAAACATGAGTTCCAGGCCGAGACAAAGAAG
CTTTTGGACATTGTTGCCCGGTCCCTGTACTCAGAAAAAGAGGTGTTTATACGGGAGCTGATCTCCAATGCCAGCGATGCCTTGGAAAAA
CTGCGTCACAAACTGGTGTCTGACGGCCAAGCACTGCCAGAAATGGAGATTCACTTGCAGACCAATGCCGAGAAAGGCACCATCACCATC
CAGGATACTGGTATCGGGATGACACAGGAAGAGCTGGTGTCCAACCTGGGGACGATTGCCAGATCGGGGTCAAAGGCCTTCCTGGATGCT
CTGCAGAACCAGGCTGAGGCCAGCAGCAAGATCATCGGCCAGTTTGGAGTGGGTTTCTACTCAGCTTTCATGGTGGCTGACAGAGTGGAG
GTCTATTCCCGCTCGGCAGCCCCGGGGAGCCTGGGTTACCAGTGGCTTTCAGATGGTTCTGGAGTGTTTGAAATCGCCGAAGCTTCGGGA
GTTAGAACCGGGACAAAAATCATCATCCACCTGAAATCCGACTGCAAGGAGTTTTCCAGCGAGGCCCGGGTGCGAGATGTGGTAACGAAG
TACAGCAACTTCGTCAGCTTCCCCTTGTACTTGAATGGAAGGCGGATGAACACCTTGCAGGCCATCTGGATGATGGACCCCAAGGATGTC
CGTGAGTGGCAACATGAGGAGTTCTACCGCTACGTCGCGCAGGCTCACGACAAGCCCCGCTACACCCTGCACTATAAGACGGACGCACCG
CTCAACATCCGCAGCATCTTCTACGTGCCCGACATGAAACCGTCCATGTTTGATGTGAGCCGGGAGCTGGGCTCCAGCGTTGCACTGTAC
AGCCGCAAAGTCCTCATCCAGACCAAGGCCACGGACATCCTGCCCAAGTGGCTGCGCTTCATCCGAGGTGTGGTGGACAGTGAGGACATT
CCCCTGAACCTCAGCCGGGAGCTGCTGCAGGAGAGCGCACTCATCAGGAAACTCCGGGACGTTTTACAGCAGAGGCTGATCAAATTCTTC
ATTGACCAGAGTAAAAAAGATGCTGAGAAGTATGCAAAGTTTTTTGAAGATTACGGCCTGTTCATGCGGGAGGGCATTGTGACCGCCACC
GAGCAGGAGGTCAAGGAGGACATAGCAAAGCTGCTGCGCTACGAGTCCTCGGCGCTGCCCTCCGGGCAGCTAACCAGCCTCTCAGAATAC
GCCAGCCGCATGCGGGCCGGCACCCGCAACATCTACTACCTGTGCGCCCCCAACCGTCACCTGGCAGAGCACTCACCCTACTATGAGGCC
ATGAAGAAGAAAGACACAGAGGTTCTCTTCTGCTTTGAGCAGTTTGATGAGCTCACCCTGCTGCACCTTCGTGAGTTTGACAAGAAGAAG
CTGATCTCTGTGGAGACGGACATAGTCGTGGATCACTACAAGGAGGAGAAGTTTGAGGACAGGTCCCCAGCCGCCGAGTGCCTATCAGAG
AAGGAGACGGAGGAGCTCATGGCCTGGATGAGAAATGTGCTGGGGTCGCGTGTCACCAACGTGAAGGTGACCCTCCGACTGGACACCCAC
CCTGCCATGGTCACCGTGCTGGAGATGGGGGCTGCCCGCCACTTCCTGCGCATGCAGCAGCTGGCCAAGACCCAGGAGGAGCGCGCACAG
CTCCTGCAGCCCACGCTGGAGATCAACCCCAGGCACGCGCTCATCAAGAAGCTGAATCAGCTGCGCGCAAGCGAGCCTGGCCTGGCTCAG
CTGCTGGTGGATCAGATATACGAGAACGCCATGATTGCTGCTGGACTTGTTGACGACCCTAGGGCCATGGTGGGCCGCTTGAATGAGCTG
CTTGTCAAGGCCCTGGAGCGACACTGACAGCCAGGGGGCCAGAAGGACTGACACCACAGATGACAGCCCCACCTCCTTGAGCTTTATTTA

>In-frame_ENST00000262367_ENST00000246957_TCGA-GV-A3QI-01A_CREBBP_chr16_3841982_-_TRAP1_chr16_3740986_length(amino acids)=1186AA_start in transcript=606_stop in transcript=4166
MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATG
VNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSL
PHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQRKPILCPRRTTAQLGPRRNPAWSLQAGRL
FSTQTAEDKEEPLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRHKLVSDGQALPEMEIHLQTN
AEKGTITIQDTGIGMTQEELVSNLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGV
FEIAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYT
LHYKTDAPLNIRSIFYVPDMKPSMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVL
QQRLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESSALPSGQLTSLSEYASRMRAGTRNIYYLCAPNRHLA
EHSPYYEAMKKKDTEVLFCFEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVK
VTLRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHALIKKLNQLRASEPGLAQLLVDQIYENAMIAAGLVDDPRA

--------------------------------------------------------------
>In-frame_ENST00000262367_ENST00000246957_TCGA-GV-A3QI-01A_CREBBP_chr16_3841981_-_TRAP1_chr16_3740985_length(transcript)=4259nt_BP=2140nt
TTCTTTTTTTTTTAATTGAGGAATCAACAGCCGCCATCTTGTCGCGGACCCGACCGGGGCTTCGAGCGCGATCTACTCGGCCCCGCCGGT
CCCGGGCCCCACAACCGCCCGCGCACCCCGCTCCGCCCGGCCGGCCCGCTCCGCCCGGCCCTCGGCGCCCGCCCCGGCGGCCCCGCTCGC
CTCTCGGCTCGGCCTCCCGGAGCCCGGCGGCGGCGGCGGCGGCAGCGGCGGCGGCGGCGGCGGAACGGGGGGTGGGGGGGCCGCGGCGGC
GGCGGCGACCCCGCTCGGCGCATTGTTTTTCCTCACGGCGGCGGCGGCGGCGGGCCGCGGGCCGGGAGCGGAGCCCGGAGCCCCCTCGTC
GTCGGGCCGCGAGCGAATTCATTAAGTGGGGCGCGGGGGGGGAGCGAGGCGGCGGCGGCGGCGGCACCATGTTCTCGGGGACTGCCTGAG
CCGCCCGGCCGGGCGCCGTCGCTGCCAGCCGGGCCCGGGGGGGCGGCCGGGCCGCCGGGGCGCCCCCACCGCGGAGTGTCGCGCTCGGGA
GGCGGGCAGGGGATGAGGGGGCCGCGGCCGGCGGCGGCGGCGGCGGCCGGGGGCGGGCGGTGAGCGCTGCGGGGCGCTGTTGCTGTGGCT
GAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCGCTCGCGGCCCGCGCTCGCTCCTCT
CCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGGGGCTGTTTTCGCGAGCAGGTGAAA
ATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTCTCGGCGAATGACAGCACAGATTTT
GGATCATTGTTTGACTTGGAAAATGATCTTCCTGATGAGCTGATACCCAATGGAGGAGAATTAGGCCTTTTAAACAGTGGGAACCTTGTT
CCAGATGCTGCTTCCAAACATAAACAACTGTCGGAGCTTCTACGAGGAGGCAGCGGCTCTAGTATCAACCCAGGAATAGGAAATGTGAGC
GCCAGCAGCCCCGTGCAGCAGGGCCTGGGTGGCCAGGCTCAAGGGCAGCCGAACAGTGCTAACATGGCCAGCCTCAGTGCCATGGGCAAG
AGCCCTCTGAGCCAGGGAGATTCTTCAGCCCCCAGCCTGCCTAAACAGGCAGCCAGCACCTCTGGGCCCACCCCCGCTGCCTCCCAAGCA
CTGAATCCGCAAGCACAAAAGCAAGTGGGGCTGGCGACTAGCAGCCCTGCCACGTCACAGACTGGACCTGGTATCTGCATGAATGCTAAC
TTTAACCAGACCCACCCAGGCCTCCTCAATAGTAACTCTGGCCATAGCTTAATTAATCAGGCTTCACAAGGGCAGGCGCAAGTCATGAAT
GGATCTCTTGGGGCTGCTGGCAGAGGAAGGGGAGCTGGAATGCCGTACCCTACTCCAGCCATGCAGGGCGCCTCGAGCAGCGTGCTGGCT
GAGACCCTAACGCAGGTTTCCCCGCAAATGACTGGTCACGCGGGACTGAACACCGCACAGGCAGGAGGCATGGCCAAGATGGGAATAACT
GGGAACACAAGTCCATTTGGACAGCCCTTTAGTCAAGCTGGAGGGCAGCCAATGGGAGCCACTGGAGTGAACCCCCAGTTAGCCAGCAAA
CAGAGCATGGTCAACAGTTTGCCCACCTTCCCTACAGATATCAAGAATACTTCAGTCACCAACGTGCCAAATATGTCTCAGATGCAAACA
TCAGTGGGAATTGTACCCACACAAGCAATTGCAACAGGCCCCACTGCAGATCCTGAAAAACGCAAACTGATACAGCAGCAGCTGGTTCTA
CTGCTTCATGCTCATAAGTGTCAGAGACGAGAGCAAGCAAACGGAGAGGTTCGGGCCTGCTCGCTCCCGCATTGTCGAACCATGAAAAAC
GTTTTGAATCACATGACGCATTGTCAGGCTGGGAAAGCCTGCCAAGTTGCCCATTGTGCATCTTCACGACAAATCATCTCTCATTGGAAG
AACTGCACACGACATGACTGTCCTGTTTGCCTCCCTTTGAAAAATGCCAGTGACAAGCGAAACCAACAAAGAAAACCAATTCTGTGTCCT
CGGAGGACCACAGCCCAGTTGGGCCCCAGGCGAAACCCAGCCTGGAGCTTGCAGGCAGGACGACTGTTCAGCACGCAGACCGCCGAGGAC
AAGGAGGAACCCCTGCACTCGATTATCAGCAGCACAGAGAGCGTGCAGGGTTCCACTTCCAAACATGAGTTCCAGGCCGAGACAAAGAAG
CTTTTGGACATTGTTGCCCGGTCCCTGTACTCAGAAAAAGAGGTGTTTATACGGGAGCTGATCTCCAATGCCAGCGATGCCTTGGAAAAA
CTGCGTCACAAACTGGTGTCTGACGGCCAAGCACTGCCAGAAATGGAGATTCACTTGCAGACCAATGCCGAGAAAGGCACCATCACCATC
CAGGATACTGGTATCGGGATGACACAGGAAGAGCTGGTGTCCAACCTGGGGACGATTGCCAGATCGGGGTCAAAGGCCTTCCTGGATGCT
CTGCAGAACCAGGCTGAGGCCAGCAGCAAGATCATCGGCCAGTTTGGAGTGGGTTTCTACTCAGCTTTCATGGTGGCTGACAGAGTGGAG
GTCTATTCCCGCTCGGCAGCCCCGGGGAGCCTGGGTTACCAGTGGCTTTCAGATGGTTCTGGAGTGTTTGAAATCGCCGAAGCTTCGGGA
GTTAGAACCGGGACAAAAATCATCATCCACCTGAAATCCGACTGCAAGGAGTTTTCCAGCGAGGCCCGGGTGCGAGATGTGGTAACGAAG
TACAGCAACTTCGTCAGCTTCCCCTTGTACTTGAATGGAAGGCGGATGAACACCTTGCAGGCCATCTGGATGATGGACCCCAAGGATGTC
CGTGAGTGGCAACATGAGGAGTTCTACCGCTACGTCGCGCAGGCTCACGACAAGCCCCGCTACACCCTGCACTATAAGACGGACGCACCG
CTCAACATCCGCAGCATCTTCTACGTGCCCGACATGAAACCGTCCATGTTTGATGTGAGCCGGGAGCTGGGCTCCAGCGTTGCACTGTAC
AGCCGCAAAGTCCTCATCCAGACCAAGGCCACGGACATCCTGCCCAAGTGGCTGCGCTTCATCCGAGGTGTGGTGGACAGTGAGGACATT
CCCCTGAACCTCAGCCGGGAGCTGCTGCAGGAGAGCGCACTCATCAGGAAACTCCGGGACGTTTTACAGCAGAGGCTGATCAAATTCTTC
ATTGACCAGAGTAAAAAAGATGCTGAGAAGTATGCAAAGTTTTTTGAAGATTACGGCCTGTTCATGCGGGAGGGCATTGTGACCGCCACC
GAGCAGGAGGTCAAGGAGGACATAGCAAAGCTGCTGCGCTACGAGTCCTCGGCGCTGCCCTCCGGGCAGCTAACCAGCCTCTCAGAATAC
GCCAGCCGCATGCGGGCCGGCACCCGCAACATCTACTACCTGTGCGCCCCCAACCGTCACCTGGCAGAGCACTCACCCTACTATGAGGCC
ATGAAGAAGAAAGACACAGAGGTTCTCTTCTGCTTTGAGCAGTTTGATGAGCTCACCCTGCTGCACCTTCGTGAGTTTGACAAGAAGAAG
CTGATCTCTGTGGAGACGGACATAGTCGTGGATCACTACAAGGAGGAGAAGTTTGAGGACAGGTCCCCAGCCGCCGAGTGCCTATCAGAG
AAGGAGACGGAGGAGCTCATGGCCTGGATGAGAAATGTGCTGGGGTCGCGTGTCACCAACGTGAAGGTGACCCTCCGACTGGACACCCAC
CCTGCCATGGTCACCGTGCTGGAGATGGGGGCTGCCCGCCACTTCCTGCGCATGCAGCAGCTGGCCAAGACCCAGGAGGAGCGCGCACAG
CTCCTGCAGCCCACGCTGGAGATCAACCCCAGGCACGCGCTCATCAAGAAGCTGAATCAGCTGCGCGCAAGCGAGCCTGGCCTGGCTCAG
CTGCTGGTGGATCAGATATACGAGAACGCCATGATTGCTGCTGGACTTGTTGACGACCCTAGGGCCATGGTGGGCCGCTTGAATGAGCTG
CTTGTCAAGGCCCTGGAGCGACACTGACAGCCAGGGGGCCAGAAGGACTGACACCACAGATGACAGCCCCACCTCCTTGAGCTTTATTTA

>In-frame_ENST00000262367_ENST00000246957_TCGA-GV-A3QI-01A_CREBBP_chr16_3841981_-_TRAP1_chr16_3740985_length(amino acids)=1186AA_start in transcript=606_stop in transcript=4166
MRGAVAVAEIWPPPPPPGLRPPSPSAPARPLAARARSSPSQPAGPPTPVRALAGPAARARGCFREQVKMAENLLDGPPNPKRAKLSSPGF
SANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANM
ASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLINQAS
QGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATG
VNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSL
PHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQRKPILCPRRTTAQLGPRRNPAWSLQAGRL
FSTQTAEDKEEPLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRHKLVSDGQALPEMEIHLQTN
AEKGTITIQDTGIGMTQEELVSNLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGV
FEIAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYT
LHYKTDAPLNIRSIFYVPDMKPSMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVL
QQRLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESSALPSGQLTSLSEYASRMRAGTRNIYYLCAPNRHLA
EHSPYYEAMKKKDTEVLFCFEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVK
VTLRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHALIKKLNQLRASEPGLAQLLVDQIYENAMIAAGLVDDPRA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CREBBP-TRAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-531227_410443.33333333333332443.0SRCAP
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-531227_410443.33333333333332443.0SRCAP


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311162_1180443.33333333333332443.0ASF1A
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301162_118002405.0ASF1A
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311162_1180443.33333333333332443.0ASF1A
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301162_118002405.0ASF1A
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311433_1435443.33333333333332443.0histone
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301433_143502405.0histone
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311433_1435443.33333333333332443.0histone
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301433_143502405.0histone
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311124_1170443.33333333333332443.0histone
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301124_117002405.0histone
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311124_1170443.33333333333332443.0histone
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301124_117002405.0histone
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-130227_41002405.0SRCAP
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-130227_41002405.0SRCAP
HgeneCREBBPchr16:3841981chr16:3740985ENST00000262367-5311460_1891443.33333333333332443.0TRERF1
HgeneCREBBPchr16:3841981chr16:3740985ENST00000382070-1301460_189102405.0TRERF1
HgeneCREBBPchr16:3841982chr16:3740986ENST00000262367-5311460_1891443.33333333333332443.0TRERF1
HgeneCREBBPchr16:3841982chr16:3740986ENST00000382070-1301460_189102405.0TRERF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CREBBP-TRAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CREBBP-TRAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCREBBPC4551859RUBINSTEIN-TAYBI SYNDROME 112CLINGEN;GENOMICS_ENGLAND;UNIPROT
HgeneCREBBPC0035934Rubinstein-Taybi Syndrome6CLINGEN;CTD_human
HgeneCREBBPC0033578Prostatic Neoplasms2CTD_human
HgeneCREBBPC0376358Malignant neoplasm of prostate2CTD_human
HgeneCREBBPC4511003Acute myeloid leukemia with t(8;16)(p11;p13) translocation2ORPHANET
HgeneCREBBPC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneCREBBPC0005695Bladder Neoplasm1CTD_human
HgeneCREBBPC0007137Squamous cell carcinoma1CTD_human
HgeneCREBBPC0007138Carcinoma, Transitional Cell1CTD_human
HgeneCREBBPC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneCREBBPC0011573Endogenous depression1PSYGENET
HgeneCREBBPC0024301Lymphoma, Follicular1CTD_human
HgeneCREBBPC0036920Sezary Syndrome1CTD_human
HgeneCREBBPC0079745Lymphoma, Large-Cell, Follicular1CTD_human
HgeneCREBBPC0079758Lymphoma, Mixed-Cell, Follicular1CTD_human
HgeneCREBBPC0079765Lymphoma, Small Cleaved-Cell, Follicular1CTD_human
HgeneCREBBPC0149925Small cell carcinoma of lung1CTD_human
HgeneCREBBPC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneCREBBPC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneCREBBPC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneCREBBPC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
HgeneCREBBPC1956130Lymphoma, Follicular, Grade 11CTD_human
HgeneCREBBPC1956131Lymphoma, Follicular, Grade 31CTD_human
HgeneCREBBPC1956132Lymphoma, Follicular, Grade 21CTD_human
HgeneCREBBPC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human
TgeneTRAP1C0024623Malignant neoplasm of stomach1CTD_human
TgeneTRAP1C0029408Degenerative polyarthritis1CTD_human
TgeneTRAP1C0038356Stomach Neoplasms1CTD_human
TgeneTRAP1C0086743Osteoarthrosis Deformans1CTD_human
TgeneTRAP1C0235874Disease Exacerbation1CTD_human
TgeneTRAP1C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneTRAP1C1968949Cakut1GENOMICS_ENGLAND
TgeneTRAP1C4225671VATER/VACTERL ASSOCIATION1GENOMICS_ENGLAND