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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CRHR1-KRT16 (FusionGDB2 ID:19434)

Fusion Gene Summary for CRHR1-KRT16

check button Fusion gene summary
Fusion gene informationFusion gene name: CRHR1-KRT16
Fusion gene ID: 19434
HgeneTgene
Gene symbol

CRHR1

KRT16

Gene ID

1394

3868

Gene namecorticotropin releasing hormone receptor 1keratin 16
SynonymsCRF-R|CRF-R-1|CRF-R1|CRF1|CRFR-1|CRFR1|CRH-R-1|CRH-R1|CRHR|CRHR1LCK16|FNEPPK|K16|K1CP|KRT16A|NEPPK|PC1
Cytomap

17q21.31

17q21.2

Type of geneprotein-codingprotein-coding
Descriptioncorticotropin-releasing factor receptor 1CRH receptor 1corticotropin-releasing factor type 1 receptorseven transmembrane helix receptorkeratin, type I cytoskeletal 16cytokeratin 16focal non-epidermolytic palmoplantar keratodermakeratin 16, type I
Modification date2020031320200313
UniProtAcc

P34998

P08779

Ensembl transtripts involved in fusion geneENST00000293493, ENST00000339069, 
ENST00000314537, ENST00000352855, 
ENST00000577353, ENST00000398285, 
ENST00000548791, ENST00000551817, 
ENST00000550606, ENST00000552724, 
ENST00000547258, ENST00000551221, 
ENST00000301653, 
Fusion gene scores* DoF score13 X 3 X 7=2739 X 13 X 3=351
# samples 1611
** MAII scorelog2(16/273*10)=-0.77082904603249
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/351*10)=-1.6739675067799
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRHR1 [Title/Abstract] AND KRT16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCRHR1(43699407)-KRT16(39768976), # samples:1
CRHR1(43699407)-KRT16(39768538), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRHR1

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

18292205

HgeneCRHR1

GO:0071376

cellular response to corticotropin-releasing hormone stimulus

18292205

HgeneCRHR1

GO:1901386

negative regulation of voltage-gated calcium channel activity

18292205

TgeneKRT16

GO:0007568

aging

21916889

TgeneKRT16

GO:0030336

negative regulation of cell migration

20403371

TgeneKRT16

GO:0042633

hair cycle

21916889


check buttonFusion gene breakpoints across CRHR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KRT16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BB-A5HUCRHR1chr17

43699407

+KRT16chr17

39768976

-
ChimerDB4HNSCTCGA-BB-A5HUCRHR1chr17

43699407

+KRT16chr17

39768538

-


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Fusion Gene ORF analysis for CRHR1-KRT16

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000293493ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768976

-
5UTR-5UTRENST00000339069ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768976

-
intron-5UTRENST00000314537ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768976

-
intron-5UTRENST00000352855ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768976

-
intron-5UTRENST00000577353ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768976

-
intron-5UTRENST00000398285ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768976

-
intron-5UTRENST00000548791ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768976

-
intron-5UTRENST00000551817ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768976

-
intron-5UTRENST00000550606ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768976

-
intron-5UTRENST00000552724ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768976

-
intron-5UTRENST00000547258ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768976

-
intron-5UTRENST00000551221ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768976

-
5UTR-3CDSENST00000293493ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768538

-
5UTR-3CDSENST00000339069ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768538

-
intron-3CDSENST00000314537ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768538

-
intron-3CDSENST00000352855ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768538

-
intron-3CDSENST00000577353ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768538

-
intron-3CDSENST00000398285ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768538

-
intron-3CDSENST00000548791ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768538

-
intron-3CDSENST00000551817ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768538

-
intron-3CDSENST00000550606ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768538

-
intron-3CDSENST00000552724ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768538

-
intron-3CDSENST00000547258ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768538

-
intron-3CDSENST00000551221ENST00000301653CRHR1chr17

43699407

+KRT16chr17

39768538

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CRHR1-KRT16


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CRHR1-KRT16


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRHR1

P34998

KRT16

P08779

FUNCTION: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. {ECO:0000269|PubMed:18292205, ECO:0000269|PubMed:18801728, ECO:0000269|PubMed:23576434, ECO:0000269|PubMed:23863939}.FUNCTION: Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. {ECO:0000250|UniProtKB:Q9Z2K1}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CRHR1-KRT16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CRHR1-KRT16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CRHR1-KRT16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCRHR1P34998DB09067Corticorelin ovine triflutateLigandSmall moleculeApproved
HgeneCRHR1P34998DB09067Corticorelin ovine triflutateLigandSmall moleculeApproved
HgeneCRHR1P34998DB09067Corticorelin ovine triflutateLigandSmall moleculeApproved
HgeneCRHR1P34998DB09067Corticorelin ovine triflutateLigandSmall moleculeApproved
TgeneKRT16P08779DB01593ZincSmall moleculeApproved|Investigational
TgeneKRT16P08779DB01593ZincSmall moleculeApproved|Investigational
TgeneKRT16P08779DB14487Zinc acetateSmall moleculeApproved|Investigational
TgeneKRT16P08779DB14487Zinc acetateSmall moleculeApproved|Investigational

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Related Diseases for CRHR1-KRT16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRHR1C0001973Alcoholic Intoxication, Chronic5PSYGENET
HgeneCRHR1C0011570Mental Depression5PSYGENET
HgeneCRHR1C0011581Depressive disorder5PSYGENET
HgeneCRHR1C0041696Unipolar Depression5PSYGENET
HgeneCRHR1C0525045Mood Disorders5PSYGENET
HgeneCRHR1C1269683Major Depressive Disorder5CTD_human;PSYGENET
HgeneCRHR1C0005586Bipolar Disorder4PSYGENET
HgeneCRHR1C0003469Anxiety Disorders2CTD_human
HgeneCRHR1C0376280Anxiety States, Neurotic2CTD_human
HgeneCRHR1C1279420Anxiety neurosis (finding)2CTD_human
HgeneCRHR1C0003123Anorexia1CTD_human
HgeneCRHR1C0006142Malignant neoplasm of breast1CTD_human
HgeneCRHR1C0009171Cocaine Abuse1CTD_human
HgeneCRHR1C0011574Involutional Depression1CTD_human
HgeneCRHR1C0011616Contact Dermatitis1CTD_human
HgeneCRHR1C0020429Hyperalgesia1CTD_human
HgeneCRHR1C0029410Osteoarthritis of hip1CTD_human
HgeneCRHR1C0030201Pain, Postoperative1CTD_human
HgeneCRHR1C0033975Psychotic Disorders1PSYGENET
HgeneCRHR1C0162351Contact hypersensitivity1CTD_human
HgeneCRHR1C0178417Anhedonia1PSYGENET
HgeneCRHR1C0236736Cocaine-Related Disorders1CTD_human
HgeneCRHR1C0349204Nonorganic psychosis1PSYGENET
HgeneCRHR1C0458247Allodynia1CTD_human
HgeneCRHR1C0600427Cocaine Dependence1CTD_human
HgeneCRHR1C0678222Breast Carcinoma1CTD_human
HgeneCRHR1C0751211Hyperalgesia, Primary1CTD_human
HgeneCRHR1C0751212Hyperalgesia, Secondary1CTD_human
HgeneCRHR1C0751213Tactile Allodynia1CTD_human
HgeneCRHR1C0751214Hyperalgesia, Thermal1CTD_human
HgeneCRHR1C0751217Hyperkinesia, Generalized1CTD_human
HgeneCRHR1C1257931Mammary Neoplasms, Human1CTD_human
HgeneCRHR1C1458155Mammary Neoplasms1CTD_human
HgeneCRHR1C1571983Involutional paraphrenia1CTD_human
HgeneCRHR1C1571984Psychosis, Involutional1CTD_human
HgeneCRHR1C2936719Mechanical Allodynia1CTD_human
HgeneCRHR1C3887506Hyperkinesia1CTD_human
HgeneCRHR1C4704874Mammary Carcinoma, Human1CTD_human
TgeneKRT16C1706595Pachyonychia Congenita, Jadassohn Lewandowsky Type12CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneKRT16C4552049PALMOPLANTAR KERATODERMA, NONEPIDERMOLYTIC, FOCAL 13CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneKRT16C0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneKRT16C0005695Bladder Neoplasm1CTD_human
TgeneKRT16C0343110Epidermolytic palmoplantar keratoderma of Vorner1ORPHANET
TgeneKRT16C1721006Keratoderma, Palmoplantar, Epidermolytic1ORPHANET
TgeneKRT16C2931735Epidermolytic palmoplantar keratoderma Vorner type1ORPHANET