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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:CRIP2-MTA1 (FusionGDB2 ID:19462) |
Fusion Gene Summary for CRIP2-MTA1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: CRIP2-MTA1 | Fusion gene ID: 19462 | Hgene | Tgene | Gene symbol | CRIP2 | MTA1 | Gene ID | 1397 | 9112 |
Gene name | cysteine rich protein 2 | metastasis associated 1 | |
Synonyms | CRIP|CRP2|ESP1 | - | |
Cytomap | 14q32.33 | 14q32.33 | |
Type of gene | protein-coding | protein-coding | |
Description | cysteine-rich protein 2Cysteine-rich intestinal proteinLIM domain protein ESP1/CRP2 | metastasis-associated protein MTA1metastasis associated gene 1 protein | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | P52943 | Q13330 | |
Ensembl transtripts involved in fusion gene | ENST00000483017, ENST00000329146, ENST00000548989, | ENST00000331320, ENST00000406191, ENST00000405646, ENST00000435036, | |
Fusion gene scores | * DoF score | 8 X 5 X 6=240 | 6 X 9 X 5=270 |
# samples | 8 | 10 | |
** MAII score | log2(8/240*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/270*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CRIP2 [Title/Abstract] AND MTA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CRIP2(105941242)-MTA1(105935804), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MTA1 | GO:0010212 | response to ionizing radiation | 19805145 |
Tgene | MTA1 | GO:1902499 | positive regulation of protein autoubiquitination | 19805145 |
Fusion gene breakpoints across CRIP2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across MTA1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | ACC | TCGA-OR-A5JZ-01A | CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935804 | + |
ChimerDB4 | ACC | TCGA-OR-A5JZ-01A | CRIP2 | chr14 | 105941242 | - | MTA1 | chr14 | 105935804 | + |
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Fusion Gene ORF analysis for CRIP2-MTA1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000483017 | ENST00000331320 | CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935804 | + |
intron-3CDS | ENST00000483017 | ENST00000406191 | CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935804 | + |
intron-3CDS | ENST00000483017 | ENST00000405646 | CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935804 | + |
intron-3CDS | ENST00000483017 | ENST00000435036 | CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935804 | + |
In-frame | ENST00000329146 | ENST00000331320 | CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935804 | + |
In-frame | ENST00000329146 | ENST00000406191 | CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935804 | + |
In-frame | ENST00000329146 | ENST00000405646 | CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935804 | + |
In-frame | ENST00000329146 | ENST00000435036 | CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935804 | + |
intron-3CDS | ENST00000548989 | ENST00000331320 | CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935804 | + |
intron-3CDS | ENST00000548989 | ENST00000406191 | CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935804 | + |
intron-3CDS | ENST00000548989 | ENST00000405646 | CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935804 | + |
intron-3CDS | ENST00000548989 | ENST00000435036 | CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935804 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CRIP2-MTA1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935803 | + | 0.00679125 | 0.9932087 |
CRIP2 | chr14 | 105941242 | + | MTA1 | chr14 | 105935803 | + | 0.00679125 | 0.9932087 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CRIP2-MTA1 |
Go to FGviewer for the breakpoints of chr14:105941242-chr14:105935804 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
CRIP2 | MTA1 |
FUNCTION: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | MTA1 | chr14:105941242 | chr14:105935804 | ENST00000331320 | 17 | 21 | 697_705 | 604.3333333333334 | 716.0 | Compositional bias | Note=Poly-Pro | |
Tgene | MTA1 | chr14:105941242 | chr14:105935804 | ENST00000405646 | 16 | 20 | 697_705 | 587.3333333333334 | 699.0 | Compositional bias | Note=Poly-Pro | |
Tgene | MTA1 | chr14:105941242 | chr14:105935804 | ENST00000331320 | 17 | 21 | 696_705 | 604.3333333333334 | 716.0 | Motif | SH3-binding | |
Tgene | MTA1 | chr14:105941242 | chr14:105935804 | ENST00000405646 | 16 | 20 | 696_705 | 587.3333333333334 | 699.0 | Motif | SH3-binding |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CRIP2 | chr14:105941242 | chr14:105935804 | ENST00000329146 | + | 1 | 8 | 180_194 | 14.333333333333334 | 209.0 | Compositional bias | Note=Gly-rich |
Hgene | CRIP2 | chr14:105941242 | chr14:105935804 | ENST00000329146 | + | 1 | 8 | 63_73 | 14.333333333333334 | 209.0 | Compositional bias | Note=Gly-rich |
Hgene | CRIP2 | chr14:105941242 | chr14:105935804 | ENST00000483017 | + | 1 | 8 | 180_194 | 0 | 283.0 | Compositional bias | Note=Gly-rich |
Hgene | CRIP2 | chr14:105941242 | chr14:105935804 | ENST00000483017 | + | 1 | 8 | 63_73 | 0 | 283.0 | Compositional bias | Note=Gly-rich |
Hgene | CRIP2 | chr14:105941242 | chr14:105935804 | ENST00000329146 | + | 1 | 8 | 126_178 | 14.333333333333334 | 209.0 | Domain | LIM zinc-binding 2 |
Hgene | CRIP2 | chr14:105941242 | chr14:105935804 | ENST00000329146 | + | 1 | 8 | 5_57 | 14.333333333333334 | 209.0 | Domain | LIM zinc-binding 1 |
Hgene | CRIP2 | chr14:105941242 | chr14:105935804 | ENST00000483017 | + | 1 | 8 | 126_178 | 0 | 283.0 | Domain | LIM zinc-binding 2 |
Hgene | CRIP2 | chr14:105941242 | chr14:105935804 | ENST00000483017 | + | 1 | 8 | 5_57 | 0 | 283.0 | Domain | LIM zinc-binding 1 |
Tgene | MTA1 | chr14:105941242 | chr14:105935804 | ENST00000331320 | 17 | 21 | 165_276 | 604.3333333333334 | 716.0 | Domain | ELM2 | |
Tgene | MTA1 | chr14:105941242 | chr14:105935804 | ENST00000331320 | 17 | 21 | 1_164 | 604.3333333333334 | 716.0 | Domain | BAH | |
Tgene | MTA1 | chr14:105941242 | chr14:105935804 | ENST00000331320 | 17 | 21 | 283_335 | 604.3333333333334 | 716.0 | Domain | SANT | |
Tgene | MTA1 | chr14:105941242 | chr14:105935804 | ENST00000405646 | 16 | 20 | 165_276 | 587.3333333333334 | 699.0 | Domain | ELM2 | |
Tgene | MTA1 | chr14:105941242 | chr14:105935804 | ENST00000405646 | 16 | 20 | 1_164 | 587.3333333333334 | 699.0 | Domain | BAH | |
Tgene | MTA1 | chr14:105941242 | chr14:105935804 | ENST00000405646 | 16 | 20 | 283_335 | 587.3333333333334 | 699.0 | Domain | SANT | |
Tgene | MTA1 | chr14:105941242 | chr14:105935804 | ENST00000331320 | 17 | 21 | 545_552 | 604.3333333333334 | 716.0 | Motif | SH3-binding | |
Tgene | MTA1 | chr14:105941242 | chr14:105935804 | ENST00000405646 | 16 | 20 | 545_552 | 587.3333333333334 | 699.0 | Motif | SH3-binding | |
Tgene | MTA1 | chr14:105941242 | chr14:105935804 | ENST00000331320 | 17 | 21 | 393_420 | 604.3333333333334 | 716.0 | Zinc finger | Note=GATA-type%3B atypical | |
Tgene | MTA1 | chr14:105941242 | chr14:105935804 | ENST00000405646 | 16 | 20 | 393_420 | 587.3333333333334 | 699.0 | Zinc finger | Note=GATA-type%3B atypical |
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Fusion Gene Sequence for CRIP2-MTA1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for CRIP2-MTA1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CRIP2-MTA1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CRIP2-MTA1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MTA1 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | MTA1 | C0030567 | Parkinson Disease | 1 | CTD_human |
Tgene | MTA1 | C0269102 | Endometrioma | 1 | CTD_human |