FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CRK-GTF2I (FusionGDB2 ID:19492)

Fusion Gene Summary for CRK-GTF2I

check button Fusion gene summary
Fusion gene informationFusion gene name: CRK-GTF2I
Fusion gene ID: 19492
HgeneTgene
Gene symbol

CRK

GTF2I

Gene ID

1398

2969

Gene nameCRK proto-oncogene, adaptor proteingeneral transcription factor IIi
SynonymsCRKII|p38BAP135|BTKAP1|DIWS|GTFII-I|IB291|SPIN|TFII-I|WBS|WBSCR6
Cytomap

17p13.3

7q11.23

Type of geneprotein-codingprotein-coding
Descriptionadapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like proteingeneral transcription factor II-IBTK-associated protein, 135kDBruton tyrosine kinase-associated protein 135SRF-Phox1-interacting proteinWilliams-Beuren syndrome chromosome region 6
Modification date2020032720200313
UniProtAcc.

Q6EKJ0

Ensembl transtripts involved in fusion geneENST00000398970, ENST00000300574, 
ENST00000574295, ENST00000572145, 
ENST00000324896, ENST00000353920, 
ENST00000346152, ENST00000416070, 
ENST00000443166, ENST00000438130, 
Fusion gene scores* DoF score15 X 11 X 7=115521 X 20 X 13=5460
# samples 1825
** MAII scorelog2(18/1155*10)=-2.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/5460*10)=-4.44890095114513
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRK [Title/Abstract] AND GTF2I [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCRK(1359171)-GTF2I(74113291), # samples:2
Anticipated loss of major functional domain due to fusion event.CRK-GTF2I seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
CRK-GTF2I seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CRK-GTF2I seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRK

GO:0009966

regulation of signal transduction

17515907

HgeneCRK

GO:0032956

regulation of actin cytoskeleton organization

11870224

HgeneCRK

GO:0043087

regulation of GTPase activity

11870224

HgeneCRK

GO:0048013

ephrin receptor signaling pathway

11870224

HgeneCRK

GO:0061045

negative regulation of wound healing

17515907

HgeneCRK

GO:2000146

negative regulation of cell motility

17515907

TgeneGTF2I

GO:0016525

negative regulation of angiogenesis

19242469


check buttonFusion gene breakpoints across CRK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GTF2I (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-BC-A10T-01ACRKchr17

1359171

-GTF2Ichr7

74113291

+
ChimerDB4LIHCTCGA-BC-A10T-01ACRKchr17

1359171

-GTF2Ichr7

74113291

+


Top

Fusion Gene ORF analysis for CRK-GTF2I

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000398970ENST00000324896CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shiftENST00000398970ENST00000353920CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shiftENST00000398970ENST00000346152CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shiftENST00000398970ENST00000416070CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shiftENST00000398970ENST00000443166CRKchr17

1359171

-GTF2Ichr7

74113291

+
5CDS-intronENST00000398970ENST00000438130CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shiftENST00000300574ENST00000324896CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shiftENST00000300574ENST00000353920CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shiftENST00000300574ENST00000346152CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shiftENST00000300574ENST00000416070CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shiftENST00000300574ENST00000443166CRKchr17

1359171

-GTF2Ichr7

74113291

+
5CDS-intronENST00000300574ENST00000438130CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shiftENST00000574295ENST00000324896CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shiftENST00000574295ENST00000353920CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shiftENST00000574295ENST00000346152CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shiftENST00000574295ENST00000416070CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shiftENST00000574295ENST00000443166CRKchr17

1359171

-GTF2Ichr7

74113291

+
5CDS-intronENST00000574295ENST00000438130CRKchr17

1359171

-GTF2Ichr7

74113291

+
intron-3CDSENST00000572145ENST00000324896CRKchr17

1359171

-GTF2Ichr7

74113291

+
intron-3CDSENST00000572145ENST00000353920CRKchr17

1359171

-GTF2Ichr7

74113291

+
intron-3CDSENST00000572145ENST00000346152CRKchr17

1359171

-GTF2Ichr7

74113291

+
intron-3CDSENST00000572145ENST00000416070CRKchr17

1359171

-GTF2Ichr7

74113291

+
intron-3CDSENST00000572145ENST00000443166CRKchr17

1359171

-GTF2Ichr7

74113291

+
intron-intronENST00000572145ENST00000438130CRKchr17

1359171

-GTF2Ichr7

74113291

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for CRK-GTF2I


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CRKchr171359170-GTF2Ichr774113290+1.27E-141
CRKchr171359170-GTF2Ichr774113290+1.27E-141

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CRK-GTF2I


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GTF2I

Q6EKJ0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for CRK-GTF2I


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CRK-GTF2I


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CRK-GTF2I


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CRK-GTF2I


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRKC0151744Myocardial Ischemia1CTD_human
TgeneGTF2IC0004238Atrial Fibrillation2CTD_human
TgeneGTF2IC0175702Williams Syndrome2CTD_human
TgeneGTF2IC0235480Paroxysmal atrial fibrillation2CTD_human
TgeneGTF2IC2585653Persistent atrial fibrillation2CTD_human
TgeneGTF2IC3468561familial atrial fibrillation2CTD_human
TgeneGTF2IC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneGTF2IC0026998Acute Myeloid Leukemia, M11CTD_human
TgeneGTF2IC0086981Sicca Syndrome1CTD_human
TgeneGTF2IC1266101Thymic epithelial tumor1CTD_human
TgeneGTF2IC1510586Autism Spectrum Disorders1CTD_human
TgeneGTF2IC1527336Sjogren's Syndrome1CTD_human
TgeneGTF2IC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human