FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CRK-SMG6 (FusionGDB2 ID:19498)

Fusion Gene Summary for CRK-SMG6

check button Fusion gene summary
Fusion gene informationFusion gene name: CRK-SMG6
Fusion gene ID: 19498
HgeneTgene
Gene symbol

CRK

SMG6

Gene ID

1398

23293

Gene nameCRK proto-oncogene, adaptor proteinSMG6 nonsense mediated mRNA decay factor
SynonymsCRKII|p38C17orf31|EST1A|SMG-6|hSMG5/7a
Cytomap

17p13.3

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionadapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like proteintelomerase-binding protein EST1AEST1 telomerase component homolog Aever shorter telomeres 1Asmg-6 homolog, nonsense mediated mRNA decay factortelomerase subunit EST1A
Modification date2020032720200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000398970, ENST00000300574, 
ENST00000574295, ENST00000572145, 
ENST00000544865, ENST00000263073, 
ENST00000354901, ENST00000536871, 
ENST00000573166, 
Fusion gene scores* DoF score15 X 11 X 7=115521 X 16 X 8=2688
# samples 1822
** MAII scorelog2(18/1155*10)=-2.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2688*10)=-3.6109577092541
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRK [Title/Abstract] AND SMG6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCRK(1359171)-SMG6(1964916), # samples:2
Anticipated loss of major functional domain due to fusion event.CRK-SMG6 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CRK-SMG6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRK

GO:0009966

regulation of signal transduction

17515907

HgeneCRK

GO:0032956

regulation of actin cytoskeleton organization

11870224

HgeneCRK

GO:0043087

regulation of GTPase activity

11870224

HgeneCRK

GO:0048013

ephrin receptor signaling pathway

11870224

HgeneCRK

GO:0061045

negative regulation of wound healing

17515907

HgeneCRK

GO:2000146

negative regulation of cell motility

17515907

TgeneSMG6

GO:1904354

negative regulation of telomere capping

12676087


check buttonFusion gene breakpoints across CRK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SMG6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1842-01ACRKchr17

1359171

-SMG6chr17

1964916

-
ChimerDB4OVTCGA-24-1842-01ACRKchr17

1359171

-SMG6chr17

1964916

-


Top

Fusion Gene ORF analysis for CRK-SMG6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000398970ENST00000544865CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000398970ENST00000263073CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000398970ENST00000354901CRKchr17

1359171

-SMG6chr17

1964916

-
Frame-shiftENST00000398970ENST00000536871CRKchr17

1359171

-SMG6chr17

1964916

-
5CDS-5UTRENST00000398970ENST00000573166CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000300574ENST00000544865CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000300574ENST00000263073CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000300574ENST00000354901CRKchr17

1359171

-SMG6chr17

1964916

-
Frame-shiftENST00000300574ENST00000536871CRKchr17

1359171

-SMG6chr17

1964916

-
5CDS-5UTRENST00000300574ENST00000573166CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000574295ENST00000544865CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000574295ENST00000263073CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000574295ENST00000354901CRKchr17

1359171

-SMG6chr17

1964916

-
Frame-shiftENST00000574295ENST00000536871CRKchr17

1359171

-SMG6chr17

1964916

-
5CDS-5UTRENST00000574295ENST00000573166CRKchr17

1359171

-SMG6chr17

1964916

-
intron-3CDSENST00000572145ENST00000544865CRKchr17

1359171

-SMG6chr17

1964916

-
intron-3CDSENST00000572145ENST00000263073CRKchr17

1359171

-SMG6chr17

1964916

-
intron-3CDSENST00000572145ENST00000354901CRKchr17

1359171

-SMG6chr17

1964916

-
intron-3CDSENST00000572145ENST00000536871CRKchr17

1359171

-SMG6chr17

1964916

-
intron-5UTRENST00000572145ENST00000573166CRKchr17

1359171

-SMG6chr17

1964916

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398970CRKchr171359171-ENST00000544865SMG6chr171964916-21313474741013179
ENST00000398970CRKchr171359171-ENST00000263073SMG6chr171964916-21273474741013179
ENST00000398970CRKchr171359171-ENST00000354901SMG6chr171964916-21203474741013179
ENST00000300574CRKchr171359171-ENST00000544865SMG6chr171964916-21663825091048179
ENST00000300574CRKchr171359171-ENST00000263073SMG6chr171964916-21623825091048179
ENST00000300574CRKchr171359171-ENST00000354901SMG6chr171964916-21553825091048179
ENST00000574295CRKchr171359171-ENST00000544865SMG6chr171964916-2057273400939179
ENST00000574295CRKchr171359171-ENST00000263073SMG6chr171964916-2053273400939179
ENST00000574295CRKchr171359171-ENST00000354901SMG6chr171964916-2046273400939179

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398970ENST00000544865CRKchr171359171-SMG6chr171964916-0.72034120.27965882
ENST00000398970ENST00000263073CRKchr171359171-SMG6chr171964916-0.71205620.2879438
ENST00000398970ENST00000354901CRKchr171359171-SMG6chr171964916-0.7088430.291157
ENST00000300574ENST00000544865CRKchr171359171-SMG6chr171964916-0.752048550.2479515
ENST00000300574ENST00000263073CRKchr171359171-SMG6chr171964916-0.7428530.257147
ENST00000300574ENST00000354901CRKchr171359171-SMG6chr171964916-0.7535190.246481
ENST00000574295ENST00000544865CRKchr171359171-SMG6chr171964916-0.83015110.16984893
ENST00000574295ENST00000263073CRKchr171359171-SMG6chr171964916-0.82409780.1759022
ENST00000574295ENST00000354901CRKchr171359171-SMG6chr171964916-0.82347860.17652148

Top

Fusion Genomic Features for CRK-SMG6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CRK-SMG6


check button Go to

FGviewer for the breakpoints of chr17:1359171-chr17:1964916

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSMG6chr17:1359171chr17:1964916ENST0000035490110121197_1239468.3333333333333512.0Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST000003549011012567_625468.3333333333333512.0Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST000005368719111197_1239468.3333333333333512.0Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST00000536871911567_625468.3333333333333512.0Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST0000035490110121246_1397468.3333333333333512.0DomainNote=PINc
TgeneSMG6chr17:1359171chr17:1964916ENST000005368719111246_1397468.3333333333333512.0DomainNote=PINc

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCRKchr17:1359171chr17:1964916ENST00000300574-13132_19280.33333333333333305.0DomainSH3 1
HgeneCRKchr17:1359171chr17:1964916ENST00000300574-1313_11880.33333333333333305.0DomainSH2
HgeneCRKchr17:1359171chr17:1964916ENST00000300574-13235_29680.33333333333333305.0DomainSH3 2
HgeneCRKchr17:1359171chr17:1964916ENST00000398970-13132_19280.33333333333333205.0DomainSH3 1
HgeneCRKchr17:1359171chr17:1964916ENST00000398970-1313_11880.33333333333333205.0DomainSH2
HgeneCRKchr17:1359171chr17:1964916ENST00000398970-13235_29680.33333333333333205.0DomainSH3 2
TgeneSMG6chr17:1359171chr17:1964916ENST0000026307317191197_12391376.33333333333331420.0Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST000002630731719163_1931376.33333333333331420.0Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST000002630731719567_6251376.33333333333331420.0Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST000003549011012163_193468.3333333333333512.0Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST00000536871911163_193468.3333333333333512.0Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST0000054486517191197_12391345.33333333333331389.0Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST000005448651719163_1931345.33333333333331389.0Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST000005448651719567_6251345.33333333333331389.0Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST0000026307317191246_13971376.33333333333331420.0DomainNote=PINc
TgeneSMG6chr17:1359171chr17:1964916ENST0000054486517191246_13971345.33333333333331389.0DomainNote=PINc


Top

Fusion Gene Sequence for CRK-SMG6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000398970_ENST00000544865_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(transcript)=2131nt_BP=347nt
GCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCCGGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTT
AGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGC
GCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTC
GCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCG
GCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGC
CTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAGT
GTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGCCACGGCCATGCTGTGG
GGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGCT
GGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGAG
GGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGCAGTGAAATCACAGTTC
CCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCTC
CCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCCCACCTCTTCTACCATC
CACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCGT
GGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGCC
TTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCAG
AATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCGGTTCCTCGTCATAGGG
GTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGTG
CTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCTC
ACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCTTCCTTACCAAGAATGA
GTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAATCTTAATGGGACCAGTG
GGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGCC
AGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGAG
TACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAGACCCAGCTCTCCTTTC

>In-frame_ENST00000398970_ENST00000544865_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(amino acids)=179AA_start in transcript=474_stop in transcript=1013
MREPHWGPPPVEPFLKGHQAPSVARKMPTCLSHQSTQTINHPLPTHATAMLWGTCSSQSPSQGSGGSCWDPPGLPGFSREVAGYSNSSWA

--------------------------------------------------------------
>In-frame_ENST00000398970_ENST00000263073_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(transcript)=2127nt_BP=347nt
GCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCCGGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTT
AGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGC
GCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTC
GCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCG
GCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGC
CTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAGT
GTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGCCACGGCCATGCTGTGG
GGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGCT
GGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGAG
GGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGCAGTGAAATCACAGTTC
CCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCTC
CCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCCCACCTCTTCTACCATC
CACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCGT
GGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGCC
TTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCAG
AATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCGGTTCCTCGTCATAGGG
GTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGTG
CTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCTC
ACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCTTCCTTACCAAGAATGA
GTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAATCTTAATGGGACCAGTG
GGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGCC
AGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGAG
TACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAGACCCAGCTCTCCTTTC

>In-frame_ENST00000398970_ENST00000263073_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(amino acids)=179AA_start in transcript=474_stop in transcript=1013
MREPHWGPPPVEPFLKGHQAPSVARKMPTCLSHQSTQTINHPLPTHATAMLWGTCSSQSPSQGSGGSCWDPPGLPGFSREVAGYSNSSWA

--------------------------------------------------------------
>In-frame_ENST00000398970_ENST00000354901_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(transcript)=2120nt_BP=347nt
GCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCCGGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTT
AGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGC
GCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTC
GCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCG
GCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGC
CTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAGT
GTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGCCACGGCCATGCTGTGG
GGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGCT
GGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGAG
GGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGCAGTGAAATCACAGTTC
CCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCTC
CCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCCCACCTCTTCTACCATC
CACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCGT
GGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGCC
TTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCAG
AATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCGGTTCCTCGTCATAGGG
GTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGTG
CTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCTC
ACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCTTCCTTACCAAGAATGA
GTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAATCTTAATGGGACCAGTG
GGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGCC
AGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGAG
TACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAGACCCAGCTCTCCTTTC

>In-frame_ENST00000398970_ENST00000354901_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(amino acids)=179AA_start in transcript=474_stop in transcript=1013
MREPHWGPPPVEPFLKGHQAPSVARKMPTCLSHQSTQTINHPLPTHATAMLWGTCSSQSPSQGSGGSCWDPPGLPGFSREVAGYSNSSWA

--------------------------------------------------------------
>In-frame_ENST00000300574_ENST00000544865_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(transcript)=2166nt_BP=382nt
GGGGGAGGCCCGCGGCTGCCGCCGCCATTTCGGGCGCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCC
GGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGG
TACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGC
CCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCG
TCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCG
CTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCG
TGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAGTGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACC
ATCCTCTTCCAACCCACGCCACGGCCATGCTGTGGGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACC
CTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGCTGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTT
TCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGAGGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTT
CTGAGTTTCCGTCAGATGCAGTGAAATCACAGTTCCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTC
AGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCTCCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCT
AACAGCAGCCCTGGGCCCCCACCTCTTCTACCATCCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAAC
CTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCGTGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGG
GTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGCCTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCC
CTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCAGAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCC
CCTTCATTTCTTCACCGCGGTTCCTCGTCATAGGGGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGT
CTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGTGCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGG
CACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCTCACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTG
GTACCTCAGTGGGGAGGCTTCCTTACCAAGAATGAGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTC
GGTGGAGCCAGGGGCAAATCTTAATGGGACCAGTGGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGC
GCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGCCAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAG
TCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGAGTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGA
CTGGGTGGTCGGGAGGGAGACCCAGCTCTCCTTTCTGTCCCGTTTGCAGCACTGGTTTTGTTTCCTTAATAAATTTTTAGTTATGAAACA

>In-frame_ENST00000300574_ENST00000544865_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(amino acids)=179AA_start in transcript=509_stop in transcript=1048
MREPHWGPPPVEPFLKGHQAPSVARKMPTCLSHQSTQTINHPLPTHATAMLWGTCSSQSPSQGSGGSCWDPPGLPGFSREVAGYSNSSWA

--------------------------------------------------------------
>In-frame_ENST00000300574_ENST00000263073_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(transcript)=2162nt_BP=382nt
GGGGGAGGCCCGCGGCTGCCGCCGCCATTTCGGGCGCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCC
GGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGG
TACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGC
CCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCG
TCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCG
CTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCG
TGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAGTGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACC
ATCCTCTTCCAACCCACGCCACGGCCATGCTGTGGGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACC
CTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGCTGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTT
TCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGAGGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTT
CTGAGTTTCCGTCAGATGCAGTGAAATCACAGTTCCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTC
AGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCTCCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCT
AACAGCAGCCCTGGGCCCCCACCTCTTCTACCATCCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAAC
CTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCGTGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGG
GTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGCCTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCC
CTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCAGAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCC
CCTTCATTTCTTCACCGCGGTTCCTCGTCATAGGGGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGT
CTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGTGCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGG
CACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCTCACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTG
GTACCTCAGTGGGGAGGCTTCCTTACCAAGAATGAGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTC
GGTGGAGCCAGGGGCAAATCTTAATGGGACCAGTGGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGC
GCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGCCAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAG
TCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGAGTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGA
CTGGGTGGTCGGGAGGGAGACCCAGCTCTCCTTTCTGTCCCGTTTGCAGCACTGGTTTTGTTTCCTTAATAAATTTTTAGTTATGAAACA

>In-frame_ENST00000300574_ENST00000263073_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(amino acids)=179AA_start in transcript=509_stop in transcript=1048
MREPHWGPPPVEPFLKGHQAPSVARKMPTCLSHQSTQTINHPLPTHATAMLWGTCSSQSPSQGSGGSCWDPPGLPGFSREVAGYSNSSWA

--------------------------------------------------------------
>In-frame_ENST00000300574_ENST00000354901_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(transcript)=2155nt_BP=382nt
GGGGGAGGCCCGCGGCTGCCGCCGCCATTTCGGGCGCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCC
GGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGG
TACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGC
CCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCG
TCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCG
CTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCG
TGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAGTGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACC
ATCCTCTTCCAACCCACGCCACGGCCATGCTGTGGGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACC
CTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGCTGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTT
TCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGAGGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTT
CTGAGTTTCCGTCAGATGCAGTGAAATCACAGTTCCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTC
AGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCTCCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCT
AACAGCAGCCCTGGGCCCCCACCTCTTCTACCATCCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAAC
CTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCGTGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGG
GTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGCCTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCC
CTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCAGAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCC
CCTTCATTTCTTCACCGCGGTTCCTCGTCATAGGGGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGT
CTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGTGCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGG
CACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCTCACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTG
GTACCTCAGTGGGGAGGCTTCCTTACCAAGAATGAGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTC
GGTGGAGCCAGGGGCAAATCTTAATGGGACCAGTGGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGC
GCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGCCAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAG
TCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGAGTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGA

>In-frame_ENST00000300574_ENST00000354901_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(amino acids)=179AA_start in transcript=509_stop in transcript=1048
MREPHWGPPPVEPFLKGHQAPSVARKMPTCLSHQSTQTINHPLPTHATAMLWGTCSSQSPSQGSGGSCWDPPGLPGFSREVAGYSNSSWA

--------------------------------------------------------------
>In-frame_ENST00000574295_ENST00000544865_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(transcript)=2057nt_BP=273nt
CGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTC
GGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCA
GCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGC
CCGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTG
TACGGGACATCCCAGCCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGG
CCACCAGGCGCCCAGTGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGC
CACGGCCATGCTGTGGGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATT
TAGCAGGGAGGTGGCTGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCAT
TCCAAGGCTGAGGGAGGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGC
AGTGAAATCACAGTTCCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGT
GTGTGTCCCCAGTCTCCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCC
CACCTCTTCTACCATCCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCG
CCAGTTGCGTCCCCGTGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCC
TCTCTCCTCACTGGCCTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCG
CCTACCCTCCCTCCAGAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCG
GTTCCTCGTCATAGGGGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCC
ACCCTCGGCTCCTGTGCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGT
TTCTAGCTTTGCCCTCACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCT
TCCTTACCAAGAATGAGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAAT
CTTAATGGGACCAGTGGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGA
GGCCCAGGACTATGCCAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAG
ACTGGGCTCTTTGGAGTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAG

>In-frame_ENST00000574295_ENST00000544865_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(amino acids)=179AA_start in transcript=400_stop in transcript=939
MREPHWGPPPVEPFLKGHQAPSVARKMPTCLSHQSTQTINHPLPTHATAMLWGTCSSQSPSQGSGGSCWDPPGLPGFSREVAGYSNSSWA

--------------------------------------------------------------
>In-frame_ENST00000574295_ENST00000263073_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(transcript)=2053nt_BP=273nt
CGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTC
GGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCA
GCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGC
CCGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTG
TACGGGACATCCCAGCCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGG
CCACCAGGCGCCCAGTGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGC
CACGGCCATGCTGTGGGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATT
TAGCAGGGAGGTGGCTGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCAT
TCCAAGGCTGAGGGAGGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGC
AGTGAAATCACAGTTCCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGT
GTGTGTCCCCAGTCTCCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCC
CACCTCTTCTACCATCCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCG
CCAGTTGCGTCCCCGTGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCC
TCTCTCCTCACTGGCCTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCG
CCTACCCTCCCTCCAGAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCG
GTTCCTCGTCATAGGGGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCC
ACCCTCGGCTCCTGTGCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGT
TTCTAGCTTTGCCCTCACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCT
TCCTTACCAAGAATGAGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAAT
CTTAATGGGACCAGTGGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGA
GGCCCAGGACTATGCCAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAG
ACTGGGCTCTTTGGAGTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAG

>In-frame_ENST00000574295_ENST00000263073_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(amino acids)=179AA_start in transcript=400_stop in transcript=939
MREPHWGPPPVEPFLKGHQAPSVARKMPTCLSHQSTQTINHPLPTHATAMLWGTCSSQSPSQGSGGSCWDPPGLPGFSREVAGYSNSSWA

--------------------------------------------------------------
>In-frame_ENST00000574295_ENST00000354901_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(transcript)=2046nt_BP=273nt
CGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTC
GGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCA
GCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGC
CCGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTG
TACGGGACATCCCAGCCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGG
CCACCAGGCGCCCAGTGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGC
CACGGCCATGCTGTGGGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATT
TAGCAGGGAGGTGGCTGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCAT
TCCAAGGCTGAGGGAGGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGC
AGTGAAATCACAGTTCCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGT
GTGTGTCCCCAGTCTCCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCC
CACCTCTTCTACCATCCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCG
CCAGTTGCGTCCCCGTGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCC
TCTCTCCTCACTGGCCTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCG
CCTACCCTCCCTCCAGAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCG
GTTCCTCGTCATAGGGGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCC
ACCCTCGGCTCCTGTGCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGT
TTCTAGCTTTGCCCTCACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCT
TCCTTACCAAGAATGAGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAAT
CTTAATGGGACCAGTGGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGA
GGCCCAGGACTATGCCAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAG
ACTGGGCTCTTTGGAGTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAG

>In-frame_ENST00000574295_ENST00000354901_TCGA-24-1842-01A_CRK_chr17_1359171_-_SMG6_chr17_1964916_length(amino acids)=179AA_start in transcript=400_stop in transcript=939
MREPHWGPPPVEPFLKGHQAPSVARKMPTCLSHQSTQTINHPLPTHATAMLWGTCSSQSPSQGSGGSCWDPPGLPGFSREVAGYSNSSWA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CRK-SMG6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSMG6chr17:1359171chr17:1964916ENST000002630731719114_5031376.33333333333331420.0telomeric DNA
TgeneSMG6chr17:1359171chr17:1964916ENST000003549011012114_503468.3333333333333512.0telomeric DNA
TgeneSMG6chr17:1359171chr17:1964916ENST00000536871911114_503468.3333333333333512.0telomeric DNA
TgeneSMG6chr17:1359171chr17:1964916ENST000005448651719114_5031345.33333333333331389.0telomeric DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CRK-SMG6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CRK-SMG6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRKC0151744Myocardial Ischemia1CTD_human