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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CSAD-ZYG11B (FusionGDB2 ID:19651) |
Fusion Gene Summary for CSAD-ZYG11B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CSAD-ZYG11B | Fusion gene ID: 19651 | Hgene | Tgene | Gene symbol | CSAD | ZYG11B | Gene ID | 51380 | 79699 |
| Gene name | cysteine sulfinic acid decarboxylase | zyg-11 family member B, cell cycle regulator | |
| Synonyms | CSD|PCAP | ZYG11 | |
| Cytomap | 12q13.13 | 1p32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cysteine sulfinic acid decarboxylaseP-selectin cytoplasmic tail-associated proteinaspartate 1-decarboxylasecysteine sulfinic acid decarboxylase-related proteincysteine-sulfinate decarboxylasesulfinoalanine decarboxylase | protein zyg-11 homolog Bzyg-11 homolog B | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | Q9Y600 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000267085, ENST00000379843, ENST00000379846, ENST00000444623, ENST00000453446, ENST00000542115, ENST00000491654, | ENST00000443756, ENST00000545132, ENST00000294353, | |
| Fusion gene scores | * DoF score | 8 X 7 X 5=280 | 6 X 12 X 4=288 |
| # samples | 8 | 12 | |
| ** MAII score | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/288*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CSAD [Title/Abstract] AND ZYG11B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CSAD(53553904)-ZYG11B(53222130), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | CSAD-ZYG11B seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CSAD-ZYG11B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across CSAD (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across ZYG11B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-B6-A0IQ-01A | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
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Fusion Gene ORF analysis for CSAD-ZYG11B |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000267085 | ENST00000443756 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| In-frame | ENST00000267085 | ENST00000545132 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| In-frame | ENST00000267085 | ENST00000294353 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| Frame-shift | ENST00000379843 | ENST00000443756 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| Frame-shift | ENST00000379843 | ENST00000545132 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| Frame-shift | ENST00000379843 | ENST00000294353 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| In-frame | ENST00000379846 | ENST00000443756 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| In-frame | ENST00000379846 | ENST00000545132 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| In-frame | ENST00000379846 | ENST00000294353 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| Frame-shift | ENST00000444623 | ENST00000443756 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| Frame-shift | ENST00000444623 | ENST00000545132 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| Frame-shift | ENST00000444623 | ENST00000294353 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| In-frame | ENST00000453446 | ENST00000443756 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| In-frame | ENST00000453446 | ENST00000545132 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| In-frame | ENST00000453446 | ENST00000294353 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| intron-3CDS | ENST00000542115 | ENST00000443756 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| intron-3CDS | ENST00000542115 | ENST00000545132 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| intron-3CDS | ENST00000542115 | ENST00000294353 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| intron-3CDS | ENST00000491654 | ENST00000443756 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| intron-3CDS | ENST00000491654 | ENST00000545132 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| intron-3CDS | ENST00000491654 | ENST00000294353 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000267085 | CSAD | chr12 | 53553904 | - | ENST00000443756 | ZYG11B | chr1 | 53222130 | + | 3576 | 1481 | 1214 | 3475 | 753 |
| ENST00000267085 | CSAD | chr12 | 53553904 | - | ENST00000545132 | ZYG11B | chr1 | 53222130 | + | 3558 | 1481 | 1214 | 3151 | 645 |
| ENST00000267085 | CSAD | chr12 | 53553904 | - | ENST00000294353 | ZYG11B | chr1 | 53222130 | + | 9399 | 1481 | 1214 | 3685 | 823 |
| ENST00000379846 | CSAD | chr12 | 53553904 | - | ENST00000443756 | ZYG11B | chr1 | 53222130 | + | 2924 | 829 | 562 | 2823 | 753 |
| ENST00000379846 | CSAD | chr12 | 53553904 | - | ENST00000545132 | ZYG11B | chr1 | 53222130 | + | 2906 | 829 | 562 | 2499 | 645 |
| ENST00000379846 | CSAD | chr12 | 53553904 | - | ENST00000294353 | ZYG11B | chr1 | 53222130 | + | 8747 | 829 | 562 | 3033 | 823 |
| ENST00000453446 | CSAD | chr12 | 53553904 | - | ENST00000443756 | ZYG11B | chr1 | 53222130 | + | 3553 | 1458 | 1191 | 3452 | 753 |
| ENST00000453446 | CSAD | chr12 | 53553904 | - | ENST00000545132 | ZYG11B | chr1 | 53222130 | + | 3535 | 1458 | 1191 | 3128 | 645 |
| ENST00000453446 | CSAD | chr12 | 53553904 | - | ENST00000294353 | ZYG11B | chr1 | 53222130 | + | 9376 | 1458 | 1191 | 3662 | 823 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000267085 | ENST00000443756 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + | 0.011309915 | 0.9886901 |
| ENST00000267085 | ENST00000545132 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + | 0.010380758 | 0.9896192 |
| ENST00000267085 | ENST00000294353 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + | 0.000572119 | 0.99942786 |
| ENST00000379846 | ENST00000443756 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + | 0.010191059 | 0.9898089 |
| ENST00000379846 | ENST00000545132 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + | 0.007906449 | 0.9920935 |
| ENST00000379846 | ENST00000294353 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + | 0.000481056 | 0.999519 |
| ENST00000453446 | ENST00000443756 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + | 0.011271232 | 0.98872876 |
| ENST00000453446 | ENST00000545132 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + | 0.009358197 | 0.9906418 |
| ENST00000453446 | ENST00000294353 | CSAD | chr12 | 53553904 | - | ZYG11B | chr1 | 53222130 | + | 0.000567676 | 0.99943227 |
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Fusion Genomic Features for CSAD-ZYG11B |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| CSAD | chr12 | 53553903 | - | ZYG11B | chr1 | 53222129 | + | 8.80E-09 | 1 |
| CSAD | chr12 | 53553903 | - | ZYG11B | chr1 | 53222129 | + | 8.80E-09 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CSAD-ZYG11B |
| Go to FGviewer for the breakpoints of chr12:53553904-chr1:53222130 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CSAD | . |
| FUNCTION: Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate. {ECO:0000250|UniProtKB:Q9DBE0}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ZYG11B | chr12:53553904 | chr1:53222130 | ENST00000294353 | 0 | 14 | 185_208 | 10.0 | 745.0 | Repeat | Note=LRR 1 | |
| Tgene | ZYG11B | chr12:53553904 | chr1:53222130 | ENST00000294353 | 0 | 14 | 216_236 | 10.0 | 745.0 | Repeat | Note=LRR 2 | |
| Tgene | ZYG11B | chr12:53553904 | chr1:53222130 | ENST00000294353 | 0 | 14 | 237_261 | 10.0 | 745.0 | Repeat | Note=LRR 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CSAD-ZYG11B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000267085_ENST00000443756_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(transcript)=3576nt_BP=1481nt GCTTGGGGACGCACGGAGAGGTGCAGCTGGGCCGTCCAGCATCAAACACTAGCCTCCACACGTGGAAAAGACCCTGACTCCCACAGTAGA CTAGTCTTATGGGAGTCCTGGCTCTTGGGCCAGGCTGCATTAGGAAAATGGAAACCAGACTGTCTTCAAATTCTTCTGCCTAGCCTTAGC CATTAGAGAGAGGTCCTGCTAAAGATGGACTGCAAATGCGCTTGATGGAAGGAGATGTCAATTCCACTGAAGTCCTCATTTCTGCTGAGC TACCTGTGCACCCTGCCTCCGGCTCTCCTGAGCAGAGAGATCCTGATGGCTGACTCAGAAGCACTCCCCTCCCTTGCTGGGGACCCAGTG GCTGTGGAAGCCTTGCTCCGGGCCGTGTTTGGGGTTGTTGTGGATGAGGCCATTCAGAAAGGAACCAGTGTCTCCCAGAAGGTCTGTGAG TGGAAGGAGCCTGAGGAGCTGAAGCAGCTGCTGGATTTGGAGCTGCGGAGCCAGGGCGAGTCACAGAAGCAGATCCTGGAGCGGTGTCGG GCTGTGATTCGCTACAGTGTCAAGACTGGTCACCCTCGGTTCTTCAACCAGCTCTTCTCTGGGTTGGATCCCCATGCTCTGGCCGGGCGC ATTATCACTGAGAGCCTCAACACCAGCCAGTACACATATGAAATCGCCCCCGTGTTTGTGCTCATGGAAGAGGAGGTGCTGAGGAAACTG CGGGCCCTGGTGGGCTGGAGCTCTGGGGACGGAATCTTCTGCCCTGGTGGCTCCATCTCCAACATGTATGCTGTAAATCTGGCCCGCTAT CAGCGCTACCCGGATTGCAAGCAGAGGGGCCTCCGCACACTGCCGCCCCTGGCCCTATTCACATCGAAGGAGTGTCACTACTCCATCCAG AAGGGAGCTGCGTTTCTGGGACTTGGCACCGACAGTGTCCGAGTGGTCAAGGCTGATGAGAGAGGGAAAATGGTCCCCGAGGATCTGGAG AGGCAGATTGGTATGGCCGAGGCTGAGGGTGCTGTGCCGTTCCTGGTCAGTGCCACCTCTGGCACCACTGTGCTAGGGGCCTTTGACCCC CTGGAGGCAATTGCTGATGTGTGCCAGCGTCATGGGCTATGGCTGCATGTGGATGCTGCCTGGGGTGGGAGCGTCCTGCTGTCACAGACA CACAGGCATCTCCTGGATGGGATCCAGAGGGCTGACTCTGTGGCCTGGAATCCCCACAAGCTCCTCGCAGCAGGCCTGCAATGCTCTGCA CTTCTTCTCCAGGATACCTCGAACCTGCTCAAGCGCTGCCATGGGTCCCAGGCCAGCTACCTTTTCCAGCAGGACAAGTTCTACGATGTG GCTCTGGACACGGGAGACAAGGTGGTGCAGTGTGGCCGCCGTGTGGACTGTCTGAAGCTGTGGCTCATGTGGAAGGCACAGGGCGATCAA GGGCTGGAGCGGCGCATCGACCAGGCCTTTGTCCTTGCCCGGAGGAGGCGTCTCCCTATTCCTTACTTGATATCTGCTTGAATTTCTTGA CTACTCACCTTGAGAAGTTCTGTTCAGCCAGACAAGATGGAACATTGTGTCTGCAGGAACCTGGAGTATTCCCACAGGAGGTGGCTGATC GACTGCTTCGGACCATGGCTTTTCATGGTCTATTGAATGATGGAACTGTGGGTATTTTTAGGGGCAACCAGATGCGCTTAAAGCGAGCCT GCATTCGCAAAGCAAAGATCTCTGCTGTTGCTTTCCGGAAAGCTTTCTGCCACCACAAGTTAGTGGAACTTGATGCCACAGGTGTGAATG CTGATATCACGATTACAGACATTATCAGTGGGCTTGGCAGTAACAAATGGATCCAGCAGAATCTCCAGTGCCTGGTGCTGAATTCATTAA CTCTCTCCCTCGAGGATCCTTACGAGCGCTGCTTCAGCCGGCTTTCTGGCCTTCGAGCTTTAAGCATCACGAATGTTCTCTTTTACAATG AAGACCTGGCTGAAGTTGCCTCATTGCCAAGATTAGAGAGCTTGGATATTTCTAACACCTCAATCACAGACATCACTGCTCTACTGGCCT GCAAAGACCGACTCAAGTCTCTAACCATGCACCACTTGAAATGTTTAAAAATGACAACTACCCAGATACTGGATGTAGTTCGGGAACTCA AACATCTGAATCATCTTGATATCTCAGATGATAAACAGTTTACATCAGACATAGCTCTTCGCTTACTAGAACAAAAAGACATCCTACCTA ACCTTGTTTCTCTGGATGTTTCTGGGAGAAAGCACGTGACAGATAAAGCCGTTGAAGCCTTTATACAACAACGTCCAAGCATGCAATTTG TAGGTTTGCTGGCTACTGATGCTGGTTACTCTGAATTCCTCACAGGCGAAGGACATTTGAAGGTGTCTGGGGAAGCCAATGAAACTCAGA TTGCAGAAGCACTGAAGCGTTACAGTGAACGGGCATTCTTTGTTCGGGAAGCTCTATTTCATCTTTTTAGTCTGACTCATGTGATGGAAA AAACAAAGCCAGAAATTTTAAAGCTTGTGGTTACTGGGATGAGAAACCACCCTATGAATTTGCCAGTGCAACTGGCTGCAAGCGCCTGTG TATTTAACTTAACCAAGCAGGATCTTGCTGCAGGGATGCCTGTCCGACTCCTGGCTGATGTGACCCATTTGCTGCTCAAAGCCATGGAAC ATTTTCCCAATCACCAGCAGTTACAGAAGAATTGCCTCCTTTCACTTTGCAGTGACCGGATCCTTCAAGATGTTCCATTTAACAGGTTTG AAGCAGCCAAGCTTGTCATGCAGTGGCTTTGCAACCATGAGGATCAAAACATGCAAAGGATGGCAGTTGCTATCATTTCTATCCTGGCTG CCAAGCTTTCTACAGAACAAACTGCACAGCTTGGTACTGAGCTCTTCATTGTCAGGAACAATATAGCTGAAGTACAAGAATTACATTCTG AATTAATGTGGAAAGATTTTATAGACCACATCAGTAGTCTCCTACACAGTGTGGAAGTGGAAGTCAGTTACTTTGCAGCTGGAATTATTG CCCATTTAATATCCAGAGGTGAACAAGCTTGGACATTGAGTCGTAGCCAGAGGAATTCTCTGCTGGATGATTTGCATTCAGCTATTTTGA AATGGCCAACTCCAGAGTGTGAGATGGTAGCATACAGGTCCTTTAATCCATTTTTCCCATTACTTGGCTGTTTCACAACACCAGGAGTTC AGCTATGGGCAGTTTGGGCCATGCAACATGTCTGCAGCAAGAATCCTTCAAGGTATTGCAGCATGCTGATTGAAGAAGGAGGATTGCAGC ATTTATACAACATCAAAGATCATGAACATACTGATCCCCATGTCCAACAGATTGCTGTGGCCATTCTGGATAGCTTAGAAAAACACATTG TGCGCCATGGGAGGCCACCTCCCTGTAAAAAACAGCCCCAAGCCAGACTAAATTGATAGCCATAAGTATTGGATAGTTGAATCACAGGAA >In-frame_ENST00000267085_ENST00000443756_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(amino acids)=753AA_start in transcript=1214_stop in transcript=3475 MESPQAPRSRPAMLCTSSPGYLEPAQALPWVPGQLPFPAGQVLRCGSGHGRQGGAVWPPCGLSEAVAHVEGTGRSRAGAAHRPGLCPCPE EASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLRTMAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKA FCHHKLVELDATGVNADITITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLAEVASLPRLESL DISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTD KAVEAFIQQRPSMQFVGLLATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFSLTHVMEKTKPEILKLVVTGMR NHPMNLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHED QNMQRMAVAIISILAAKLSTEQTAQLGTELFIVRNNIAEVQELHSELMWKDFIDHISSLLHSVEVEVSYFAAGIIAHLISRGEQAWTLSR SQRNSLLDDLHSAILKWPTPECEMVAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNPSRYCSMLIEEGGLQHLYNIKDHEHTDPHV -------------------------------------------------------------- >In-frame_ENST00000267085_ENST00000545132_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(transcript)=3558nt_BP=1481nt GCTTGGGGACGCACGGAGAGGTGCAGCTGGGCCGTCCAGCATCAAACACTAGCCTCCACACGTGGAAAAGACCCTGACTCCCACAGTAGA CTAGTCTTATGGGAGTCCTGGCTCTTGGGCCAGGCTGCATTAGGAAAATGGAAACCAGACTGTCTTCAAATTCTTCTGCCTAGCCTTAGC CATTAGAGAGAGGTCCTGCTAAAGATGGACTGCAAATGCGCTTGATGGAAGGAGATGTCAATTCCACTGAAGTCCTCATTTCTGCTGAGC TACCTGTGCACCCTGCCTCCGGCTCTCCTGAGCAGAGAGATCCTGATGGCTGACTCAGAAGCACTCCCCTCCCTTGCTGGGGACCCAGTG GCTGTGGAAGCCTTGCTCCGGGCCGTGTTTGGGGTTGTTGTGGATGAGGCCATTCAGAAAGGAACCAGTGTCTCCCAGAAGGTCTGTGAG TGGAAGGAGCCTGAGGAGCTGAAGCAGCTGCTGGATTTGGAGCTGCGGAGCCAGGGCGAGTCACAGAAGCAGATCCTGGAGCGGTGTCGG GCTGTGATTCGCTACAGTGTCAAGACTGGTCACCCTCGGTTCTTCAACCAGCTCTTCTCTGGGTTGGATCCCCATGCTCTGGCCGGGCGC ATTATCACTGAGAGCCTCAACACCAGCCAGTACACATATGAAATCGCCCCCGTGTTTGTGCTCATGGAAGAGGAGGTGCTGAGGAAACTG CGGGCCCTGGTGGGCTGGAGCTCTGGGGACGGAATCTTCTGCCCTGGTGGCTCCATCTCCAACATGTATGCTGTAAATCTGGCCCGCTAT CAGCGCTACCCGGATTGCAAGCAGAGGGGCCTCCGCACACTGCCGCCCCTGGCCCTATTCACATCGAAGGAGTGTCACTACTCCATCCAG AAGGGAGCTGCGTTTCTGGGACTTGGCACCGACAGTGTCCGAGTGGTCAAGGCTGATGAGAGAGGGAAAATGGTCCCCGAGGATCTGGAG AGGCAGATTGGTATGGCCGAGGCTGAGGGTGCTGTGCCGTTCCTGGTCAGTGCCACCTCTGGCACCACTGTGCTAGGGGCCTTTGACCCC CTGGAGGCAATTGCTGATGTGTGCCAGCGTCATGGGCTATGGCTGCATGTGGATGCTGCCTGGGGTGGGAGCGTCCTGCTGTCACAGACA CACAGGCATCTCCTGGATGGGATCCAGAGGGCTGACTCTGTGGCCTGGAATCCCCACAAGCTCCTCGCAGCAGGCCTGCAATGCTCTGCA CTTCTTCTCCAGGATACCTCGAACCTGCTCAAGCGCTGCCATGGGTCCCAGGCCAGCTACCTTTTCCAGCAGGACAAGTTCTACGATGTG GCTCTGGACACGGGAGACAAGGTGGTGCAGTGTGGCCGCCGTGTGGACTGTCTGAAGCTGTGGCTCATGTGGAAGGCACAGGGCGATCAA GGGCTGGAGCGGCGCATCGACCAGGCCTTTGTCCTTGCCCGGAGGAGGCGTCTCCCTATTCCTTACTTGATATCTGCTTGAATTTCTTGA CTACTCACCTTGAGAAGTTCTGTTCAGCCAGACAAGATGGAACATTGTGTCTGCAGGAACCTGGAGTATTCCCACAGGAGGTGGCTGATC GACTGCTTCGGACCATGGCTTTTCATGGTCTATTGAATGATGGAACTGTGGGTATTTTTAGGGGCAACCAGATGCGCTTAAAGCGAGCCT GCATTCGCAAAGCAAAGATCTCTGCTGTTGCTTTCCGGAAAGCTTTCTGCCACCACAAGTTAGTGGAACTTGATGCCACAGGTGTGAATG CTGATATCACGATTACAGACATTATCAGTGGGCTTGGCAGTAACAAATGGATCCAGCAGAATCTCCAGTGCCTGGTGCTGAATTCATTAA CTCTCTCCCTCGAGGATCCTTACGAGCGCTGCTTCAGCCGGCTTTCTGGCCTTCGAGCTTTAAGCATCACGAATGTTCTCTTTTACAATG AAGACCTGGCTGAAGTTGCCTCATTGCCAAGATTAGAGAGCTTGGATATTTCTAACACCTCAATCACAGACATCACTGCTCTACTGGCCT GCAAAGACCGACTCAAGTCTCTAACCATGCACCACTTGAAATGTTTAAAAATGACAACTACCCAGATACTGGATGTAGTTCGGGAACTCA AACATCTGAATCATCTTGATATCTCAGATGATAAACAGTTTACATCAGACATAGCTCTTCGCTTACTAGAACAAAAAGACATCCTACCTA ACCTTGTTTCTCTGGATGTTTCTGGGAGAAAGCACGTGACAGATAAAGCCGTTGAAGCCTTTATACAACAACGTCCAAGCATGCAATTTG TAGGTTTGCTGGCTACTGATGCTGGTTACTCTGAATTCCTCACAGGCGAAGGACATTTGAAGGTGTCTGGGGAAGCCAATGAAACTCAGA TTGCAGAAGCACTGAAGCGTTACAGTGAACGGGCATTCTTTGTTCGGGAAGCTCTATTTCATCTTTTTAGTCTGACTCATGTGATGGAAA AAACAAAGCCAGAAATTTTAAAGCTTGTGGTTACTGGGATGAGAAACCACCCTATGAATTTGCCAGTGCAACTGGCTGCAAGCGCCTGTG TATTTAACTTAACCAAGCAGGATCTTGCTGCAGGGATGCCTGTCCGACTCCTGGCTGATGTGACCCATTTGCTGCTCAAAGCCATGGAAC ATTTTCCCAATCACCAGCAGTTACAGAAGAATTGCCTCCTTTCACTTTGCAGTGACCGGATCCTTCAAGATGTTCCATTTAACAGGTTTG AAGCAGCCAAGCTTGTCATGCAGTGGCTTTGCAACCATGAGGATCAAAACATGCAAAGGATGGCAGTTGCTATCATTTCTATCCTGGCTG CCAAGCTTTCTACAGAACAAACTGCACAGCTTGGTACTGAGCTCTTCATTGTCAGGCAACTTCTTCAAATAGTGAAGCAGAAAACCAATC AAAATTCAGTGGACACTACATTGAAATTTACTTTGAGTGCACTTTGGAACCTCACAGATGAATCTCCAACCACTTGTAGACACTTTATTG AAAACCAAGGGTTAGAACTCTTCATGAGGGTTCTAGAGTCTTTCCCAACTGAGTCATCCATTCAGCAGAAAGTTCTAGGACTTTTGGGTT AATATGATTATTTGATACAGAAGTTGGCTCAGGTCATCTGAAACGGAAAGAACAATATAGCTGAAGTACAAGAATTACATTCTGAATTAA TGTGGAAAGATTTTATAGACCACATCAGTAGTCTCCTACACAGTGTGGAAGTGGAAGTCAGTTACTTTGCAGCTGGAATTATTGCCCATT TAATATCCAGAGGTGAACAAGCTTGGACATTGAGTCGTAGCCAGAGGAATTCTCTGCTGGATGATTTGCATTCAGCTATTTTGAAATGGC CAACTCCAGAGTGTGAGATGGTAGCATACAGGTCCTTTAATCCATTTTTCCCATTACTTGGCTGTTTCACAACACCAGGAGTTCAGCTAT >In-frame_ENST00000267085_ENST00000545132_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(amino acids)=645AA_start in transcript=1214_stop in transcript=3151 MESPQAPRSRPAMLCTSSPGYLEPAQALPWVPGQLPFPAGQVLRCGSGHGRQGGAVWPPCGLSEAVAHVEGTGRSRAGAAHRPGLCPCPE EASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLRTMAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKA FCHHKLVELDATGVNADITITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLAEVASLPRLESL DISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTD KAVEAFIQQRPSMQFVGLLATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFSLTHVMEKTKPEILKLVVTGMR NHPMNLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHED QNMQRMAVAIISILAAKLSTEQTAQLGTELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNLTDESPTTCRHFIENQGLELFMRVLESF -------------------------------------------------------------- >In-frame_ENST00000267085_ENST00000294353_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(transcript)=9399nt_BP=1481nt GCTTGGGGACGCACGGAGAGGTGCAGCTGGGCCGTCCAGCATCAAACACTAGCCTCCACACGTGGAAAAGACCCTGACTCCCACAGTAGA CTAGTCTTATGGGAGTCCTGGCTCTTGGGCCAGGCTGCATTAGGAAAATGGAAACCAGACTGTCTTCAAATTCTTCTGCCTAGCCTTAGC CATTAGAGAGAGGTCCTGCTAAAGATGGACTGCAAATGCGCTTGATGGAAGGAGATGTCAATTCCACTGAAGTCCTCATTTCTGCTGAGC TACCTGTGCACCCTGCCTCCGGCTCTCCTGAGCAGAGAGATCCTGATGGCTGACTCAGAAGCACTCCCCTCCCTTGCTGGGGACCCAGTG GCTGTGGAAGCCTTGCTCCGGGCCGTGTTTGGGGTTGTTGTGGATGAGGCCATTCAGAAAGGAACCAGTGTCTCCCAGAAGGTCTGTGAG TGGAAGGAGCCTGAGGAGCTGAAGCAGCTGCTGGATTTGGAGCTGCGGAGCCAGGGCGAGTCACAGAAGCAGATCCTGGAGCGGTGTCGG GCTGTGATTCGCTACAGTGTCAAGACTGGTCACCCTCGGTTCTTCAACCAGCTCTTCTCTGGGTTGGATCCCCATGCTCTGGCCGGGCGC ATTATCACTGAGAGCCTCAACACCAGCCAGTACACATATGAAATCGCCCCCGTGTTTGTGCTCATGGAAGAGGAGGTGCTGAGGAAACTG CGGGCCCTGGTGGGCTGGAGCTCTGGGGACGGAATCTTCTGCCCTGGTGGCTCCATCTCCAACATGTATGCTGTAAATCTGGCCCGCTAT CAGCGCTACCCGGATTGCAAGCAGAGGGGCCTCCGCACACTGCCGCCCCTGGCCCTATTCACATCGAAGGAGTGTCACTACTCCATCCAG AAGGGAGCTGCGTTTCTGGGACTTGGCACCGACAGTGTCCGAGTGGTCAAGGCTGATGAGAGAGGGAAAATGGTCCCCGAGGATCTGGAG AGGCAGATTGGTATGGCCGAGGCTGAGGGTGCTGTGCCGTTCCTGGTCAGTGCCACCTCTGGCACCACTGTGCTAGGGGCCTTTGACCCC CTGGAGGCAATTGCTGATGTGTGCCAGCGTCATGGGCTATGGCTGCATGTGGATGCTGCCTGGGGTGGGAGCGTCCTGCTGTCACAGACA CACAGGCATCTCCTGGATGGGATCCAGAGGGCTGACTCTGTGGCCTGGAATCCCCACAAGCTCCTCGCAGCAGGCCTGCAATGCTCTGCA CTTCTTCTCCAGGATACCTCGAACCTGCTCAAGCGCTGCCATGGGTCCCAGGCCAGCTACCTTTTCCAGCAGGACAAGTTCTACGATGTG GCTCTGGACACGGGAGACAAGGTGGTGCAGTGTGGCCGCCGTGTGGACTGTCTGAAGCTGTGGCTCATGTGGAAGGCACAGGGCGATCAA GGGCTGGAGCGGCGCATCGACCAGGCCTTTGTCCTTGCCCGGAGGAGGCGTCTCCCTATTCCTTACTTGATATCTGCTTGAATTTCTTGA CTACTCACCTTGAGAAGTTCTGTTCAGCCAGACAAGATGGAACATTGTGTCTGCAGGAACCTGGAGTATTCCCACAGGAGGTGGCTGATC GACTGCTTCGGACCATGGCTTTTCATGGTCTATTGAATGATGGAACTGTGGGTATTTTTAGGGGCAACCAGATGCGCTTAAAGCGAGCCT GCATTCGCAAAGCAAAGATCTCTGCTGTTGCTTTCCGGAAAGCTTTCTGCCACCACAAGTTAGTGGAACTTGATGCCACAGGTGTGAATG CTGATATCACGATTACAGACATTATCAGTGGGCTTGGCAGTAACAAATGGATCCAGCAGAATCTCCAGTGCCTGGTGCTGAATTCATTAA CTCTCTCCCTCGAGGATCCTTACGAGCGCTGCTTCAGCCGGCTTTCTGGCCTTCGAGCTTTAAGCATCACGAATGTTCTCTTTTACAATG AAGACCTGGCTGAAGTTGCCTCATTGCCAAGATTAGAGAGCTTGGATATTTCTAACACCTCAATCACAGACATCACTGCTCTACTGGCCT GCAAAGACCGACTCAAGTCTCTAACCATGCACCACTTGAAATGTTTAAAAATGACAACTACCCAGATACTGGATGTAGTTCGGGAACTCA AACATCTGAATCATCTTGATATCTCAGATGATAAACAGTTTACATCAGACATAGCTCTTCGCTTACTAGAACAAAAAGACATCCTACCTA ACCTTGTTTCTCTGGATGTTTCTGGGAGAAAGCACGTGACAGATAAAGCCGTTGAAGCCTTTATACAACAACGTCCAAGCATGCAATTTG TAGGTTTGCTGGCTACTGATGCTGGTTACTCTGAATTCCTCACAGGCGAAGGACATTTGAAGGTGTCTGGGGAAGCCAATGAAACTCAGA TTGCAGAAGCACTGAAGCGTTACAGTGAACGGGCATTCTTTGTTCGGGAAGCTCTATTTCATCTTTTTAGTCTGACTCATGTGATGGAAA AAACAAAGCCAGAAATTTTAAAGCTTGTGGTTACTGGGATGAGAAACCACCCTATGAATTTGCCAGTGCAACTGGCTGCAAGCGCCTGTG TATTTAACTTAACCAAGCAGGATCTTGCTGCAGGGATGCCTGTCCGACTCCTGGCTGATGTGACCCATTTGCTGCTCAAAGCCATGGAAC ATTTTCCCAATCACCAGCAGTTACAGAAGAATTGCCTCCTTTCACTTTGCAGTGACCGGATCCTTCAAGATGTTCCATTTAACAGGTTTG AAGCAGCCAAGCTTGTCATGCAGTGGCTTTGCAACCATGAGGATCAAAACATGCAAAGGATGGCAGTTGCTATCATTTCTATCCTGGCTG CCAAGCTTTCTACAGAACAAACTGCACAGCTTGGTACTGAGCTCTTCATTGTCAGGCAACTTCTTCAAATAGTGAAGCAGAAAACCAATC AAAATTCAGTGGACACTACATTGAAATTTACTTTGAGTGCACTTTGGAACCTCACAGATGAATCTCCAACCACTTGTAGACACTTTATTG AAAACCAAGGGTTAGAACTCTTCATGAGGGTTCTAGAGTCTTTCCCAACTGAGTCATCCATTCAGCAGAAAGTTCTAGGACTTTTGAACA ATATAGCTGAAGTACAAGAATTACATTCTGAATTAATGTGGAAAGATTTTATAGACCACATCAGTAGTCTCCTACACAGTGTGGAAGTGG AAGTCAGTTACTTTGCAGCTGGAATTATTGCCCATTTAATATCCAGAGGTGAACAAGCTTGGACATTGAGTCGTAGCCAGAGGAATTCTC TGCTGGATGATTTGCATTCAGCTATTTTGAAATGGCCAACTCCAGAGTGTGAGATGGTAGCATACAGGTCCTTTAATCCATTTTTCCCAT TACTTGGCTGTTTCACAACACCAGGAGTTCAGCTATGGGCAGTTTGGGCCATGCAACATGTCTGCAGCAAGAATCCTTCAAGGTATTGCA GCATGCTGATTGAAGAAGGAGGATTGCAGCATTTATACAACATCAAAGATCATGAACATACTGATCCCCATGTCCAACAGATTGCTGTGG CCATTCTGGATAGCTTAGAAAAACACATTGTGCGCCATGGGAGGCCACCTCCCTGTAAAAAACAGCCCCAAGCCAGACTAAATTGATAGC CATAAGTATTGGATAGTTGAATCACAGGAATCCTTTTTGTGATTGGTCCATTTGGAATATCTTACCCTCCCTGATGTTTTGGGGGTTTCT ATGACAAGAGTCATAAAATCAGTTTGGGATTGATAATGTGTAGTACTGCCCATGTGAACAGTCTCTAATTTGTCTTGTGATTTTAAACTT ATGAGTCAAGAAGGGTCTCTTCCTTTATCATTGCCTTTTAGGAAATTTTCCACATCTTTCAGTGTTTGAACTTACTTGTGCTTGAGATTC TACAGTTTTATGGTAAAGTTTGCACGAACCCTTAGGCCAGACTTTTCTGATCTCAGAGTCCCTTCCAATCAATTTGCAGCTTCACATAAG CTGTTGACCTGATTTCTGACACTGCTTCAGTTGTAAATTTTATACTGCTTCTGTATAAAATGCCTTTCTTCTCTATCTGTGTATATTTTA TAAGATGTCCTTCTTAGTGTGAAAGAAGGGAAATGTGGATCATCTTGTGGAAGCTAATCACTGGCAGGAGCCTGGATGGCTGGCGGAAAG ATATATGAGAAAGAAAAATTATGAAGGTAGAACAGAGTGTAGGAACTGGGAATTGGTTTCATGGTATAGGTTTTAAAATGAGACAGGCTA CCCTTCGGGAGTCCACCTCTCTTGAGGCGGTGAGCAGAAGCTTGTCCTCCATATTTATACCTAGAAGTGTGGACTGCTGGTTCCTGCACA GACTGCCGGTTATTCACTAGGAATATTTCCCCAAGCACCACAGTATAAAATACTACAGCACTCTGTGTTAAAGACTAACTGTCTACATCT CCATATGTTGTAGTGTTGTGAAAATGTGATTTTAAAAAATTATCGCCAGTTAAAACTGGCTATTCTTTTCCTCTATTTCAAAGTCATTTT TGTTCAGTGGAATAGAGACAGCAACATGGTGTTAACCTCTCAATTAAAATACAATTGACACCAGTAAATTTTGCCATAAAAAGTTAAAAT CTCTTGTTCAAAATATGTGTATCTTCTTAATGTGTTCATGTTAGAGAAAGTGTCCCCATCTCACTGCCAAAAATGAAAGAAAATAATTAA ACTCTTTAAATGATTAAATGTAATGATTCTACTCGCAGTGCATAACAGCACATATTTTTGACAGATTATTTTTTAGGCAATTACCTTTCC TTAAGGTATCTGATACAGTATAGTAAAGAATCACTTATATCAGTAATAGCACTTGAGAGATAGCAAGTCACCAAGAAACTTAATTTTCAT TTAAAATTTTATTTTGTGAATAAGGTCAATCTACAATCCCAGATAACTACATTTTTTTTCATAGATGGCCAGTGTTTTCAACAGAGATTT AAAATGGAATATTAAAATTATAGTGATTATTCAGAAGCATTTTAATTTAGAAAGGAGCTGGTTTGTTAGTTCACTGATGACATTTTTTGA CAAACATTTTATACCATTATCACAATAATCAGACTTGAATTTTTTTTGGAGTTCCTTCATGTGAATGAAAACTGAGTTAAAAGAAAGTAG GCATTTAGGTCTGGATGCAGTGGCTCATGCTTGTAATCCCAGCACTTTGGGAAGCTGAAGCAGGAGGATTGCTTGAGCCCAGAAGTTCAA GACTAGCCTGGGCAACATAGTGAGACTCGGTCTCTACCAAAAAAAAAAATTTTTTTTTTTTAAATTAGCTGGGTGTGGTGGCACCTGGGA AACAGAGCGAGACGCTGACTCAAATAAATATCTAAATAGATATTTAGAATCACTGAAAACCATATTAAATGCTGGGTTAATGCTGACTTA ATTGGCTTAAGGAATTTTTATAGGCGTAAGATAAATTTTCACAGACTAAGTTTATTTCAGACAAAATAGAGAATTCTTTTAAAAGTTTTT TTTTTTTTTTTCCTTTTTCGAATGTTAATGTCTAAGACAAAGTTCAGAAAACGAGATGGCCTGTGGTAGTTTGGAAATTGCTAGATATGT TGACCGTTTCCAGGTCTTTTATCTAGTGTAGTTAAGGGAAAGCCTATTTAAGAAGTTTGGCTTCAAGTTTCTGTTTTATAAGACAAAAGT GCATATTTCTTTACAGGCTAATGCTAGGTTTTTGTCTTTACAAATTATTTTCAGAAATGGCTAAAAGTGTACAGAAAACAGTAAATCCCT TCTTTACTCAGAATAACTTCTTAATAGTTGAAGCATCCAAAATATGTAAAAGCAAGGGTGGGCGTAGTGGCTCTTGCCTGTAATCCCAGC ATTCTGGGAGGCCGAGGCGGGCAGATCACTTGAGATCAGGAGTTCGAGACCACCCTGGCCAACGTGGTGAAACCCCGTCTCTACTAAAAA TACAAAAACTAGCTGGGCATGGTGGCTTTTTTGCACGCCTATAGTCCCAGCTACTCGGGAGGCTGAGGCACGAGAATCACTTGAACCCAG GAAGTGGAGGTTGCAGTGAGCTAAGATCGTGCCACTGCACTCCAGCCTGGACAACGGAGTGAGACTCTGGGGAAAAAAAAAATTAAACTT CCTACTTTTTTTCTTTTTGTAGAGACAGAGTTTCACTCTGTCGCCCAAGCTGGAGTGCAGTGGCACAATCATACCTCACTGCAGCCTCTT GGGCTTATGTGATCTTACCCCCTCAGCCTCTGGAGTAGCTGGAACTACAGGCTAAATTTCCTACTTTGTAAACATCAGTAGTGGCCAGAT ACTTCTGAGTCTTAAAAGCATAATAGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACA AGGTCAGGAGTTCAAGACCAGCCTGGCCCAAATGGTGAAACCCTGTCTCTACTAAATATACAAAAATTAGCTGGGTGTGGTGGCGGGCAC CTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGTGGAGGTTGTGGTGAGCCAATATCATGCCACTGC ACTCCAGCCTGGGTGACAGAGTAAGACTCCGTCTCAAAAAAAAAAAAAGCATAATAATTTATTACATCCCAAATATATAAAAATTTGAGT GCCTTTGCAGTTGGGATGGTTCCTAAAATTGCGTATAGAATTAAGGCACAGAATTGTGTGTAAGGTCCTGAATCTGGCTAAAATACAGTG GATGTATGTATTGGAATTATGAGGCATAAGTAGCCAGTATCTATAGTTAGAATCTACAAGGCCTCCTTTTTGCACCTGTAGACTAGAATA TAACTGTTATTGGTGCCTTTGAGTGTTATCTCTCAGTGGCTAGAGGTGCTGTTTCAAGCACAATTTAGACTAGGGTTGAACCACTCATTG TTCAAATCATTGGTGGGCTCCAATGTAAAATATCACTACATCAGTCCACAAGCAACATTAAGGAAATCTAAAGGAAATGGAATTTGACTT TTTAGAGTATAATGATGTTCTAGGGCATAATGAGGAAAATTTTTAAAAAATAGATTATAATGATACATATTGGTATCATTAAGACAACAG ATTTGAGCAAATACAATTAAGGTGTCTTATTTTTTGCATCAAGTAATTATTGCTGTGGTCTTTCTACTCCACAAAATAATTTTTTCTTTT TGCAGTTGAAAATTAACTGCATTATTAACTAATTAATAAAATAAATCAAGTGGTATAAGGGATTAGTTTACCCTCAAGCCGATGACTCCA TGGCTACTGATATTAGTTAGTTTAGGATTTTTAAAAAGCATATCAGACCCCCAGTTTCAGGAATTGAGTATAAATATTGCTTCTTGTCAC CCTGGGACAGTAATGCCTTATAGTGGCACTAGTCACCTTAAGTAGATTACACATGGTTGAGGTGAATAAAGCTGCATGGGAATTTGCTTT CGTGATATATTTCATTTGCAAACTTCTACATAATCAAGTTTTATGTTTAAAACCATCGGTTCTATATATCTAGCTTTAGGAAGTTGCCCT TACAGGTGGGACCTTTTGTGTTAATCTGTTTTCTCCCCAGTCATCTTATTTGGCTATGTTAAAAAAAAAAAAAAAAAAAAAGCGAGAGAG AGAGATGGTGTCTCACTGTGTTGCCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTGACTTTCCCACCTCAGCTTCCCAAAGTGCTGGAAT CACAGGCATGAGCCACAGTGCCTGGTCTTAGCTGTGTTTTTAATTATGCCATGCATCAACATAACACCGGGCCATCTTCCTATCCCTTCC TATCCCATATGTTTAATGAAAACATATTTTATGTGCTAAATTAGGTTAATTTACCAGAGATTTAGCTTAGTGTTTTTAAACTATAGAACA ATACCCCTATAGAACAATGTACAGCTGCACCCAAGGTTAAAAAGAGGTAGCAGGGAAAACAAACTTAAACTCTTTGTATATGGTGAAACC CATCCCTCTCCTGCCCTCTAATGGTATGTTTACATTATTTCGTTATTATACAATGTAGTGGTATAAACAGTATTATTAAACTGAAGGCAT AAGTTAAAGGAAGTATGTTACTTTGAGCTGATGTAGGCTCTTCCACTTTTATCTGTATTTTACTTATTTGGGGACTTTGTATTGCTAGGG CTTCAGAATACTAACTTTGACACAGCTCCCAGAGAGGTTTGCAAACTTTTGGTTTCCCTCTCAAATCCATGGTAGTAGTTTCAAATGAGT TTGTGGATAATGGATGTTTAGTCCTTATCATTTGCTGTGTTTTGACAGTTTTTAATTTGCAGTATTCACTCACGAACTGTTTTATTTTAG GAATAATGCAAAACCAACCTTCGTCCGGTGATGAGAATAGCCGTATGATAAGAGAATTTGCTCATCGTGCTTTAAATGATTAACTGTTTT ACCTTATTTAGTATTTCATAGACTTTGCATGATATGGTACACTCCTAATTATGCATTCTTTGGTTTCCAAATCTTAATCTAAGATACTTT GTTAACTGACTGGTAGCCTAAGAAAGAGACTTTTCTTCCTGTTTTTCTCTCTCCCCATTTTTTGGGGTAAGTTTTGCAAAGATCAGTGCT GCTTCTCATGACTCTAAAGTAAAGCTCTTTTGGATAGCACAGCCTAACTTTACAGCTAGACAGAATGGCCATTAAGAATATTTCCAAAAT CCAAGTTTATCAAAATTATTTTGTGGGAAATCATCAATCTATTTTATTAATGTTATGTGTTTAATTTTGGACTTATTTTGGGAAAAACTG TTCAAATTGGGTCCTTTTAAGCTTATTTTAAGCAGCCTAGAAGGAAGAAGCTACTTAGCTAATGAAAGCTGAGACACTTTATTAAAAGCA GGATCTTAAGAGCATTGTTTTTCCTTAAAAACTTTATACTCTCAGATAATCTGCAACAACAAAAATTAAGAAATCCCTGACTTTTGTAGA ATTCCCACTGTCAAATTCTCACTGACTTATGAGTGTGAGAGAAGTTATCTTTTGTTTGAATTCTGATAGAACAGTTTAACTCCTTTCTAA GGATATAAAAAATTCATTGGAAAGTGTGTATATTTCAAAGACTCTCAATTATCTGGACTGAAGGCACTGTTCTCACTATGGCCAGATGAA TGGGAGTATTCTGTACATGAATCATGCTGTATTTTAAATCAGGACATCACTTAAGTATTAATGTTGTGTGTACAGATTTTTGTTTTGGGA >In-frame_ENST00000267085_ENST00000294353_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(amino acids)=823AA_start in transcript=1214_stop in transcript=3685 MESPQAPRSRPAMLCTSSPGYLEPAQALPWVPGQLPFPAGQVLRCGSGHGRQGGAVWPPCGLSEAVAHVEGTGRSRAGAAHRPGLCPCPE EASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLRTMAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKA FCHHKLVELDATGVNADITITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLAEVASLPRLESL DISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTD KAVEAFIQQRPSMQFVGLLATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFSLTHVMEKTKPEILKLVVTGMR NHPMNLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHED QNMQRMAVAIISILAAKLSTEQTAQLGTELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNLTDESPTTCRHFIENQGLELFMRVLESF PTESSIQQKVLGLLNNIAEVQELHSELMWKDFIDHISSLLHSVEVEVSYFAAGIIAHLISRGEQAWTLSRSQRNSLLDDLHSAILKWPTP ECEMVAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNPSRYCSMLIEEGGLQHLYNIKDHEHTDPHVQQIAVAILDSLEKHIVRHGR -------------------------------------------------------------- >In-frame_ENST00000379846_ENST00000443756_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(transcript)=2924nt_BP=829nt GCTTGGGGACGCACGGAGAGGTGCAGCTGGGGTGGCTCACACCTGTAATCCCAGCACGTTGGGAAGCCGAGGTGGGGAATGACTCTGCTC TGCCACAGATCCTGATGGCTGACTCAGAAGCACTCCCCTCCCTTGCTGGGGACCCAGTGGCTGTGGAAGCCTTGCTCCGGGCCGTGTTTG GGGTTGTTGTGGATGAGGCCATTCAGAAAGGAACCAGTGTCTCCCAGAAGTGTCACTACTCCATCCAGAAGGGAGCTGCGTTTCTGGGAC TTGGCACCGACAGTGTCCGAGTGGTCAAGGCTGATGAGAGAGGGAAAATGGTCCCCGAGGATCTGGAGAGGCAGATTGGTATGGCCGAGG CTGAGGGTGCTGTGCCGTTCCTGGTCAGTGCCACCTCTGGCACCACTGTGCTAGGGGCCTTTGACCCCCTGGAGGCAATTGCTGATGTGT GCCAGCGTCATGGGCTATGGCTGCATGTGGATGCTGCCTGGGGTGGGAGCGTCCTGCTGTCACAGACACACAGGCATCTCCTGGATGGGA TCCAGAGGGCTGACTCTGTGGCCTGGAATCCCCACAAGCTCCTCGCAGCAGGCCTGCAATGCTCTGCACTTCTTCTCCAGGATACCTCGA ACCTGCTCAAGCGCTGCCATGGGTCCCAGGCCAGCTACCTTTTCCAGCAGGACAAGTTCTACGATGTGGCTCTGGACACGGGAGACAAGG TGGTGCAGTGTGGCCGCCGTGTGGACTGTCTGAAGCTGTGGCTCATGTGGAAGGCACAGGGCGATCAAGGGCTGGAGCGGCGCATCGACC AGGCCTTTGTCCTTGCCCGGAGGAGGCGTCTCCCTATTCCTTACTTGATATCTGCTTGAATTTCTTGACTACTCACCTTGAGAAGTTCTG TTCAGCCAGACAAGATGGAACATTGTGTCTGCAGGAACCTGGAGTATTCCCACAGGAGGTGGCTGATCGACTGCTTCGGACCATGGCTTT TCATGGTCTATTGAATGATGGAACTGTGGGTATTTTTAGGGGCAACCAGATGCGCTTAAAGCGAGCCTGCATTCGCAAAGCAAAGATCTC TGCTGTTGCTTTCCGGAAAGCTTTCTGCCACCACAAGTTAGTGGAACTTGATGCCACAGGTGTGAATGCTGATATCACGATTACAGACAT TATCAGTGGGCTTGGCAGTAACAAATGGATCCAGCAGAATCTCCAGTGCCTGGTGCTGAATTCATTAACTCTCTCCCTCGAGGATCCTTA CGAGCGCTGCTTCAGCCGGCTTTCTGGCCTTCGAGCTTTAAGCATCACGAATGTTCTCTTTTACAATGAAGACCTGGCTGAAGTTGCCTC ATTGCCAAGATTAGAGAGCTTGGATATTTCTAACACCTCAATCACAGACATCACTGCTCTACTGGCCTGCAAAGACCGACTCAAGTCTCT AACCATGCACCACTTGAAATGTTTAAAAATGACAACTACCCAGATACTGGATGTAGTTCGGGAACTCAAACATCTGAATCATCTTGATAT CTCAGATGATAAACAGTTTACATCAGACATAGCTCTTCGCTTACTAGAACAAAAAGACATCCTACCTAACCTTGTTTCTCTGGATGTTTC TGGGAGAAAGCACGTGACAGATAAAGCCGTTGAAGCCTTTATACAACAACGTCCAAGCATGCAATTTGTAGGTTTGCTGGCTACTGATGC TGGTTACTCTGAATTCCTCACAGGCGAAGGACATTTGAAGGTGTCTGGGGAAGCCAATGAAACTCAGATTGCAGAAGCACTGAAGCGTTA CAGTGAACGGGCATTCTTTGTTCGGGAAGCTCTATTTCATCTTTTTAGTCTGACTCATGTGATGGAAAAAACAAAGCCAGAAATTTTAAA GCTTGTGGTTACTGGGATGAGAAACCACCCTATGAATTTGCCAGTGCAACTGGCTGCAAGCGCCTGTGTATTTAACTTAACCAAGCAGGA TCTTGCTGCAGGGATGCCTGTCCGACTCCTGGCTGATGTGACCCATTTGCTGCTCAAAGCCATGGAACATTTTCCCAATCACCAGCAGTT ACAGAAGAATTGCCTCCTTTCACTTTGCAGTGACCGGATCCTTCAAGATGTTCCATTTAACAGGTTTGAAGCAGCCAAGCTTGTCATGCA GTGGCTTTGCAACCATGAGGATCAAAACATGCAAAGGATGGCAGTTGCTATCATTTCTATCCTGGCTGCCAAGCTTTCTACAGAACAAAC TGCACAGCTTGGTACTGAGCTCTTCATTGTCAGGAACAATATAGCTGAAGTACAAGAATTACATTCTGAATTAATGTGGAAAGATTTTAT AGACCACATCAGTAGTCTCCTACACAGTGTGGAAGTGGAAGTCAGTTACTTTGCAGCTGGAATTATTGCCCATTTAATATCCAGAGGTGA ACAAGCTTGGACATTGAGTCGTAGCCAGAGGAATTCTCTGCTGGATGATTTGCATTCAGCTATTTTGAAATGGCCAACTCCAGAGTGTGA GATGGTAGCATACAGGTCCTTTAATCCATTTTTCCCATTACTTGGCTGTTTCACAACACCAGGAGTTCAGCTATGGGCAGTTTGGGCCAT GCAACATGTCTGCAGCAAGAATCCTTCAAGGTATTGCAGCATGCTGATTGAAGAAGGAGGATTGCAGCATTTATACAACATCAAAGATCA TGAACATACTGATCCCCATGTCCAACAGATTGCTGTGGCCATTCTGGATAGCTTAGAAAAACACATTGTGCGCCATGGGAGGCCACCTCC CTGTAAAAAACAGCCCCAAGCCAGACTAAATTGATAGCCATAAGTATTGGATAGTTGAATCACAGGAATCCTTTTTGTGATTGGTCCATT >In-frame_ENST00000379846_ENST00000443756_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(amino acids)=753AA_start in transcript=562_stop in transcript=2823 MESPQAPRSRPAMLCTSSPGYLEPAQALPWVPGQLPFPAGQVLRCGSGHGRQGGAVWPPCGLSEAVAHVEGTGRSRAGAAHRPGLCPCPE EASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLRTMAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKA FCHHKLVELDATGVNADITITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLAEVASLPRLESL DISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTD KAVEAFIQQRPSMQFVGLLATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFSLTHVMEKTKPEILKLVVTGMR NHPMNLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHED QNMQRMAVAIISILAAKLSTEQTAQLGTELFIVRNNIAEVQELHSELMWKDFIDHISSLLHSVEVEVSYFAAGIIAHLISRGEQAWTLSR SQRNSLLDDLHSAILKWPTPECEMVAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNPSRYCSMLIEEGGLQHLYNIKDHEHTDPHV -------------------------------------------------------------- >In-frame_ENST00000379846_ENST00000545132_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(transcript)=2906nt_BP=829nt GCTTGGGGACGCACGGAGAGGTGCAGCTGGGGTGGCTCACACCTGTAATCCCAGCACGTTGGGAAGCCGAGGTGGGGAATGACTCTGCTC TGCCACAGATCCTGATGGCTGACTCAGAAGCACTCCCCTCCCTTGCTGGGGACCCAGTGGCTGTGGAAGCCTTGCTCCGGGCCGTGTTTG GGGTTGTTGTGGATGAGGCCATTCAGAAAGGAACCAGTGTCTCCCAGAAGTGTCACTACTCCATCCAGAAGGGAGCTGCGTTTCTGGGAC TTGGCACCGACAGTGTCCGAGTGGTCAAGGCTGATGAGAGAGGGAAAATGGTCCCCGAGGATCTGGAGAGGCAGATTGGTATGGCCGAGG CTGAGGGTGCTGTGCCGTTCCTGGTCAGTGCCACCTCTGGCACCACTGTGCTAGGGGCCTTTGACCCCCTGGAGGCAATTGCTGATGTGT GCCAGCGTCATGGGCTATGGCTGCATGTGGATGCTGCCTGGGGTGGGAGCGTCCTGCTGTCACAGACACACAGGCATCTCCTGGATGGGA TCCAGAGGGCTGACTCTGTGGCCTGGAATCCCCACAAGCTCCTCGCAGCAGGCCTGCAATGCTCTGCACTTCTTCTCCAGGATACCTCGA ACCTGCTCAAGCGCTGCCATGGGTCCCAGGCCAGCTACCTTTTCCAGCAGGACAAGTTCTACGATGTGGCTCTGGACACGGGAGACAAGG TGGTGCAGTGTGGCCGCCGTGTGGACTGTCTGAAGCTGTGGCTCATGTGGAAGGCACAGGGCGATCAAGGGCTGGAGCGGCGCATCGACC AGGCCTTTGTCCTTGCCCGGAGGAGGCGTCTCCCTATTCCTTACTTGATATCTGCTTGAATTTCTTGACTACTCACCTTGAGAAGTTCTG TTCAGCCAGACAAGATGGAACATTGTGTCTGCAGGAACCTGGAGTATTCCCACAGGAGGTGGCTGATCGACTGCTTCGGACCATGGCTTT TCATGGTCTATTGAATGATGGAACTGTGGGTATTTTTAGGGGCAACCAGATGCGCTTAAAGCGAGCCTGCATTCGCAAAGCAAAGATCTC TGCTGTTGCTTTCCGGAAAGCTTTCTGCCACCACAAGTTAGTGGAACTTGATGCCACAGGTGTGAATGCTGATATCACGATTACAGACAT TATCAGTGGGCTTGGCAGTAACAAATGGATCCAGCAGAATCTCCAGTGCCTGGTGCTGAATTCATTAACTCTCTCCCTCGAGGATCCTTA CGAGCGCTGCTTCAGCCGGCTTTCTGGCCTTCGAGCTTTAAGCATCACGAATGTTCTCTTTTACAATGAAGACCTGGCTGAAGTTGCCTC ATTGCCAAGATTAGAGAGCTTGGATATTTCTAACACCTCAATCACAGACATCACTGCTCTACTGGCCTGCAAAGACCGACTCAAGTCTCT AACCATGCACCACTTGAAATGTTTAAAAATGACAACTACCCAGATACTGGATGTAGTTCGGGAACTCAAACATCTGAATCATCTTGATAT CTCAGATGATAAACAGTTTACATCAGACATAGCTCTTCGCTTACTAGAACAAAAAGACATCCTACCTAACCTTGTTTCTCTGGATGTTTC TGGGAGAAAGCACGTGACAGATAAAGCCGTTGAAGCCTTTATACAACAACGTCCAAGCATGCAATTTGTAGGTTTGCTGGCTACTGATGC TGGTTACTCTGAATTCCTCACAGGCGAAGGACATTTGAAGGTGTCTGGGGAAGCCAATGAAACTCAGATTGCAGAAGCACTGAAGCGTTA CAGTGAACGGGCATTCTTTGTTCGGGAAGCTCTATTTCATCTTTTTAGTCTGACTCATGTGATGGAAAAAACAAAGCCAGAAATTTTAAA GCTTGTGGTTACTGGGATGAGAAACCACCCTATGAATTTGCCAGTGCAACTGGCTGCAAGCGCCTGTGTATTTAACTTAACCAAGCAGGA TCTTGCTGCAGGGATGCCTGTCCGACTCCTGGCTGATGTGACCCATTTGCTGCTCAAAGCCATGGAACATTTTCCCAATCACCAGCAGTT ACAGAAGAATTGCCTCCTTTCACTTTGCAGTGACCGGATCCTTCAAGATGTTCCATTTAACAGGTTTGAAGCAGCCAAGCTTGTCATGCA GTGGCTTTGCAACCATGAGGATCAAAACATGCAAAGGATGGCAGTTGCTATCATTTCTATCCTGGCTGCCAAGCTTTCTACAGAACAAAC TGCACAGCTTGGTACTGAGCTCTTCATTGTCAGGCAACTTCTTCAAATAGTGAAGCAGAAAACCAATCAAAATTCAGTGGACACTACATT GAAATTTACTTTGAGTGCACTTTGGAACCTCACAGATGAATCTCCAACCACTTGTAGACACTTTATTGAAAACCAAGGGTTAGAACTCTT CATGAGGGTTCTAGAGTCTTTCCCAACTGAGTCATCCATTCAGCAGAAAGTTCTAGGACTTTTGGGTTAATATGATTATTTGATACAGAA GTTGGCTCAGGTCATCTGAAACGGAAAGAACAATATAGCTGAAGTACAAGAATTACATTCTGAATTAATGTGGAAAGATTTTATAGACCA CATCAGTAGTCTCCTACACAGTGTGGAAGTGGAAGTCAGTTACTTTGCAGCTGGAATTATTGCCCATTTAATATCCAGAGGTGAACAAGC TTGGACATTGAGTCGTAGCCAGAGGAATTCTCTGCTGGATGATTTGCATTCAGCTATTTTGAAATGGCCAACTCCAGAGTGTGAGATGGT AGCATACAGGTCCTTTAATCCATTTTTCCCATTACTTGGCTGTTTCACAACACCAGGAGTTCAGCTATGGGCAGTTTGGGCCATGCAACA >In-frame_ENST00000379846_ENST00000545132_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(amino acids)=645AA_start in transcript=562_stop in transcript=2499 MESPQAPRSRPAMLCTSSPGYLEPAQALPWVPGQLPFPAGQVLRCGSGHGRQGGAVWPPCGLSEAVAHVEGTGRSRAGAAHRPGLCPCPE EASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLRTMAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKA FCHHKLVELDATGVNADITITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLAEVASLPRLESL DISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTD KAVEAFIQQRPSMQFVGLLATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFSLTHVMEKTKPEILKLVVTGMR NHPMNLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHED QNMQRMAVAIISILAAKLSTEQTAQLGTELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNLTDESPTTCRHFIENQGLELFMRVLESF -------------------------------------------------------------- >In-frame_ENST00000379846_ENST00000294353_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(transcript)=8747nt_BP=829nt GCTTGGGGACGCACGGAGAGGTGCAGCTGGGGTGGCTCACACCTGTAATCCCAGCACGTTGGGAAGCCGAGGTGGGGAATGACTCTGCTC TGCCACAGATCCTGATGGCTGACTCAGAAGCACTCCCCTCCCTTGCTGGGGACCCAGTGGCTGTGGAAGCCTTGCTCCGGGCCGTGTTTG GGGTTGTTGTGGATGAGGCCATTCAGAAAGGAACCAGTGTCTCCCAGAAGTGTCACTACTCCATCCAGAAGGGAGCTGCGTTTCTGGGAC TTGGCACCGACAGTGTCCGAGTGGTCAAGGCTGATGAGAGAGGGAAAATGGTCCCCGAGGATCTGGAGAGGCAGATTGGTATGGCCGAGG CTGAGGGTGCTGTGCCGTTCCTGGTCAGTGCCACCTCTGGCACCACTGTGCTAGGGGCCTTTGACCCCCTGGAGGCAATTGCTGATGTGT GCCAGCGTCATGGGCTATGGCTGCATGTGGATGCTGCCTGGGGTGGGAGCGTCCTGCTGTCACAGACACACAGGCATCTCCTGGATGGGA TCCAGAGGGCTGACTCTGTGGCCTGGAATCCCCACAAGCTCCTCGCAGCAGGCCTGCAATGCTCTGCACTTCTTCTCCAGGATACCTCGA ACCTGCTCAAGCGCTGCCATGGGTCCCAGGCCAGCTACCTTTTCCAGCAGGACAAGTTCTACGATGTGGCTCTGGACACGGGAGACAAGG TGGTGCAGTGTGGCCGCCGTGTGGACTGTCTGAAGCTGTGGCTCATGTGGAAGGCACAGGGCGATCAAGGGCTGGAGCGGCGCATCGACC AGGCCTTTGTCCTTGCCCGGAGGAGGCGTCTCCCTATTCCTTACTTGATATCTGCTTGAATTTCTTGACTACTCACCTTGAGAAGTTCTG TTCAGCCAGACAAGATGGAACATTGTGTCTGCAGGAACCTGGAGTATTCCCACAGGAGGTGGCTGATCGACTGCTTCGGACCATGGCTTT TCATGGTCTATTGAATGATGGAACTGTGGGTATTTTTAGGGGCAACCAGATGCGCTTAAAGCGAGCCTGCATTCGCAAAGCAAAGATCTC TGCTGTTGCTTTCCGGAAAGCTTTCTGCCACCACAAGTTAGTGGAACTTGATGCCACAGGTGTGAATGCTGATATCACGATTACAGACAT TATCAGTGGGCTTGGCAGTAACAAATGGATCCAGCAGAATCTCCAGTGCCTGGTGCTGAATTCATTAACTCTCTCCCTCGAGGATCCTTA CGAGCGCTGCTTCAGCCGGCTTTCTGGCCTTCGAGCTTTAAGCATCACGAATGTTCTCTTTTACAATGAAGACCTGGCTGAAGTTGCCTC ATTGCCAAGATTAGAGAGCTTGGATATTTCTAACACCTCAATCACAGACATCACTGCTCTACTGGCCTGCAAAGACCGACTCAAGTCTCT AACCATGCACCACTTGAAATGTTTAAAAATGACAACTACCCAGATACTGGATGTAGTTCGGGAACTCAAACATCTGAATCATCTTGATAT CTCAGATGATAAACAGTTTACATCAGACATAGCTCTTCGCTTACTAGAACAAAAAGACATCCTACCTAACCTTGTTTCTCTGGATGTTTC TGGGAGAAAGCACGTGACAGATAAAGCCGTTGAAGCCTTTATACAACAACGTCCAAGCATGCAATTTGTAGGTTTGCTGGCTACTGATGC TGGTTACTCTGAATTCCTCACAGGCGAAGGACATTTGAAGGTGTCTGGGGAAGCCAATGAAACTCAGATTGCAGAAGCACTGAAGCGTTA CAGTGAACGGGCATTCTTTGTTCGGGAAGCTCTATTTCATCTTTTTAGTCTGACTCATGTGATGGAAAAAACAAAGCCAGAAATTTTAAA GCTTGTGGTTACTGGGATGAGAAACCACCCTATGAATTTGCCAGTGCAACTGGCTGCAAGCGCCTGTGTATTTAACTTAACCAAGCAGGA TCTTGCTGCAGGGATGCCTGTCCGACTCCTGGCTGATGTGACCCATTTGCTGCTCAAAGCCATGGAACATTTTCCCAATCACCAGCAGTT ACAGAAGAATTGCCTCCTTTCACTTTGCAGTGACCGGATCCTTCAAGATGTTCCATTTAACAGGTTTGAAGCAGCCAAGCTTGTCATGCA GTGGCTTTGCAACCATGAGGATCAAAACATGCAAAGGATGGCAGTTGCTATCATTTCTATCCTGGCTGCCAAGCTTTCTACAGAACAAAC TGCACAGCTTGGTACTGAGCTCTTCATTGTCAGGCAACTTCTTCAAATAGTGAAGCAGAAAACCAATCAAAATTCAGTGGACACTACATT GAAATTTACTTTGAGTGCACTTTGGAACCTCACAGATGAATCTCCAACCACTTGTAGACACTTTATTGAAAACCAAGGGTTAGAACTCTT CATGAGGGTTCTAGAGTCTTTCCCAACTGAGTCATCCATTCAGCAGAAAGTTCTAGGACTTTTGAACAATATAGCTGAAGTACAAGAATT ACATTCTGAATTAATGTGGAAAGATTTTATAGACCACATCAGTAGTCTCCTACACAGTGTGGAAGTGGAAGTCAGTTACTTTGCAGCTGG AATTATTGCCCATTTAATATCCAGAGGTGAACAAGCTTGGACATTGAGTCGTAGCCAGAGGAATTCTCTGCTGGATGATTTGCATTCAGC TATTTTGAAATGGCCAACTCCAGAGTGTGAGATGGTAGCATACAGGTCCTTTAATCCATTTTTCCCATTACTTGGCTGTTTCACAACACC AGGAGTTCAGCTATGGGCAGTTTGGGCCATGCAACATGTCTGCAGCAAGAATCCTTCAAGGTATTGCAGCATGCTGATTGAAGAAGGAGG ATTGCAGCATTTATACAACATCAAAGATCATGAACATACTGATCCCCATGTCCAACAGATTGCTGTGGCCATTCTGGATAGCTTAGAAAA ACACATTGTGCGCCATGGGAGGCCACCTCCCTGTAAAAAACAGCCCCAAGCCAGACTAAATTGATAGCCATAAGTATTGGATAGTTGAAT CACAGGAATCCTTTTTGTGATTGGTCCATTTGGAATATCTTACCCTCCCTGATGTTTTGGGGGTTTCTATGACAAGAGTCATAAAATCAG TTTGGGATTGATAATGTGTAGTACTGCCCATGTGAACAGTCTCTAATTTGTCTTGTGATTTTAAACTTATGAGTCAAGAAGGGTCTCTTC CTTTATCATTGCCTTTTAGGAAATTTTCCACATCTTTCAGTGTTTGAACTTACTTGTGCTTGAGATTCTACAGTTTTATGGTAAAGTTTG CACGAACCCTTAGGCCAGACTTTTCTGATCTCAGAGTCCCTTCCAATCAATTTGCAGCTTCACATAAGCTGTTGACCTGATTTCTGACAC TGCTTCAGTTGTAAATTTTATACTGCTTCTGTATAAAATGCCTTTCTTCTCTATCTGTGTATATTTTATAAGATGTCCTTCTTAGTGTGA AAGAAGGGAAATGTGGATCATCTTGTGGAAGCTAATCACTGGCAGGAGCCTGGATGGCTGGCGGAAAGATATATGAGAAAGAAAAATTAT GAAGGTAGAACAGAGTGTAGGAACTGGGAATTGGTTTCATGGTATAGGTTTTAAAATGAGACAGGCTACCCTTCGGGAGTCCACCTCTCT TGAGGCGGTGAGCAGAAGCTTGTCCTCCATATTTATACCTAGAAGTGTGGACTGCTGGTTCCTGCACAGACTGCCGGTTATTCACTAGGA ATATTTCCCCAAGCACCACAGTATAAAATACTACAGCACTCTGTGTTAAAGACTAACTGTCTACATCTCCATATGTTGTAGTGTTGTGAA AATGTGATTTTAAAAAATTATCGCCAGTTAAAACTGGCTATTCTTTTCCTCTATTTCAAAGTCATTTTTGTTCAGTGGAATAGAGACAGC AACATGGTGTTAACCTCTCAATTAAAATACAATTGACACCAGTAAATTTTGCCATAAAAAGTTAAAATCTCTTGTTCAAAATATGTGTAT CTTCTTAATGTGTTCATGTTAGAGAAAGTGTCCCCATCTCACTGCCAAAAATGAAAGAAAATAATTAAACTCTTTAAATGATTAAATGTA ATGATTCTACTCGCAGTGCATAACAGCACATATTTTTGACAGATTATTTTTTAGGCAATTACCTTTCCTTAAGGTATCTGATACAGTATA GTAAAGAATCACTTATATCAGTAATAGCACTTGAGAGATAGCAAGTCACCAAGAAACTTAATTTTCATTTAAAATTTTATTTTGTGAATA AGGTCAATCTACAATCCCAGATAACTACATTTTTTTTCATAGATGGCCAGTGTTTTCAACAGAGATTTAAAATGGAATATTAAAATTATA GTGATTATTCAGAAGCATTTTAATTTAGAAAGGAGCTGGTTTGTTAGTTCACTGATGACATTTTTTGACAAACATTTTATACCATTATCA CAATAATCAGACTTGAATTTTTTTTGGAGTTCCTTCATGTGAATGAAAACTGAGTTAAAAGAAAGTAGGCATTTAGGTCTGGATGCAGTG GCTCATGCTTGTAATCCCAGCACTTTGGGAAGCTGAAGCAGGAGGATTGCTTGAGCCCAGAAGTTCAAGACTAGCCTGGGCAACATAGTG AGACTCGGTCTCTACCAAAAAAAAAAATTTTTTTTTTTTAAATTAGCTGGGTGTGGTGGCACCTGGGAAACAGAGCGAGACGCTGACTCA AATAAATATCTAAATAGATATTTAGAATCACTGAAAACCATATTAAATGCTGGGTTAATGCTGACTTAATTGGCTTAAGGAATTTTTATA GGCGTAAGATAAATTTTCACAGACTAAGTTTATTTCAGACAAAATAGAGAATTCTTTTAAAAGTTTTTTTTTTTTTTTTCCTTTTTCGAA TGTTAATGTCTAAGACAAAGTTCAGAAAACGAGATGGCCTGTGGTAGTTTGGAAATTGCTAGATATGTTGACCGTTTCCAGGTCTTTTAT CTAGTGTAGTTAAGGGAAAGCCTATTTAAGAAGTTTGGCTTCAAGTTTCTGTTTTATAAGACAAAAGTGCATATTTCTTTACAGGCTAAT GCTAGGTTTTTGTCTTTACAAATTATTTTCAGAAATGGCTAAAAGTGTACAGAAAACAGTAAATCCCTTCTTTACTCAGAATAACTTCTT AATAGTTGAAGCATCCAAAATATGTAAAAGCAAGGGTGGGCGTAGTGGCTCTTGCCTGTAATCCCAGCATTCTGGGAGGCCGAGGCGGGC AGATCACTTGAGATCAGGAGTTCGAGACCACCCTGGCCAACGTGGTGAAACCCCGTCTCTACTAAAAATACAAAAACTAGCTGGGCATGG TGGCTTTTTTGCACGCCTATAGTCCCAGCTACTCGGGAGGCTGAGGCACGAGAATCACTTGAACCCAGGAAGTGGAGGTTGCAGTGAGCT AAGATCGTGCCACTGCACTCCAGCCTGGACAACGGAGTGAGACTCTGGGGAAAAAAAAAATTAAACTTCCTACTTTTTTTCTTTTTGTAG AGACAGAGTTTCACTCTGTCGCCCAAGCTGGAGTGCAGTGGCACAATCATACCTCACTGCAGCCTCTTGGGCTTATGTGATCTTACCCCC TCAGCCTCTGGAGTAGCTGGAACTACAGGCTAAATTTCCTACTTTGTAAACATCAGTAGTGGCCAGATACTTCTGAGTCTTAAAAGCATA ATAGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACAAGGTCAGGAGTTCAAGACCAGC CTGGCCCAAATGGTGAAACCCTGTCTCTACTAAATATACAAAAATTAGCTGGGTGTGGTGGCGGGCACCTGTAATCCCAGCTACTCAGGA GGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGTGGAGGTTGTGGTGAGCCAATATCATGCCACTGCACTCCAGCCTGGGTGACAGAGT AAGACTCCGTCTCAAAAAAAAAAAAAGCATAATAATTTATTACATCCCAAATATATAAAAATTTGAGTGCCTTTGCAGTTGGGATGGTTC CTAAAATTGCGTATAGAATTAAGGCACAGAATTGTGTGTAAGGTCCTGAATCTGGCTAAAATACAGTGGATGTATGTATTGGAATTATGA GGCATAAGTAGCCAGTATCTATAGTTAGAATCTACAAGGCCTCCTTTTTGCACCTGTAGACTAGAATATAACTGTTATTGGTGCCTTTGA GTGTTATCTCTCAGTGGCTAGAGGTGCTGTTTCAAGCACAATTTAGACTAGGGTTGAACCACTCATTGTTCAAATCATTGGTGGGCTCCA ATGTAAAATATCACTACATCAGTCCACAAGCAACATTAAGGAAATCTAAAGGAAATGGAATTTGACTTTTTAGAGTATAATGATGTTCTA GGGCATAATGAGGAAAATTTTTAAAAAATAGATTATAATGATACATATTGGTATCATTAAGACAACAGATTTGAGCAAATACAATTAAGG TGTCTTATTTTTTGCATCAAGTAATTATTGCTGTGGTCTTTCTACTCCACAAAATAATTTTTTCTTTTTGCAGTTGAAAATTAACTGCAT TATTAACTAATTAATAAAATAAATCAAGTGGTATAAGGGATTAGTTTACCCTCAAGCCGATGACTCCATGGCTACTGATATTAGTTAGTT TAGGATTTTTAAAAAGCATATCAGACCCCCAGTTTCAGGAATTGAGTATAAATATTGCTTCTTGTCACCCTGGGACAGTAATGCCTTATA GTGGCACTAGTCACCTTAAGTAGATTACACATGGTTGAGGTGAATAAAGCTGCATGGGAATTTGCTTTCGTGATATATTTCATTTGCAAA CTTCTACATAATCAAGTTTTATGTTTAAAACCATCGGTTCTATATATCTAGCTTTAGGAAGTTGCCCTTACAGGTGGGACCTTTTGTGTT AATCTGTTTTCTCCCCAGTCATCTTATTTGGCTATGTTAAAAAAAAAAAAAAAAAAAAAGCGAGAGAGAGAGATGGTGTCTCACTGTGTT GCCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTGACTTTCCCACCTCAGCTTCCCAAAGTGCTGGAATCACAGGCATGAGCCACAGTGCC TGGTCTTAGCTGTGTTTTTAATTATGCCATGCATCAACATAACACCGGGCCATCTTCCTATCCCTTCCTATCCCATATGTTTAATGAAAA CATATTTTATGTGCTAAATTAGGTTAATTTACCAGAGATTTAGCTTAGTGTTTTTAAACTATAGAACAATACCCCTATAGAACAATGTAC AGCTGCACCCAAGGTTAAAAAGAGGTAGCAGGGAAAACAAACTTAAACTCTTTGTATATGGTGAAACCCATCCCTCTCCTGCCCTCTAAT GGTATGTTTACATTATTTCGTTATTATACAATGTAGTGGTATAAACAGTATTATTAAACTGAAGGCATAAGTTAAAGGAAGTATGTTACT TTGAGCTGATGTAGGCTCTTCCACTTTTATCTGTATTTTACTTATTTGGGGACTTTGTATTGCTAGGGCTTCAGAATACTAACTTTGACA CAGCTCCCAGAGAGGTTTGCAAACTTTTGGTTTCCCTCTCAAATCCATGGTAGTAGTTTCAAATGAGTTTGTGGATAATGGATGTTTAGT CCTTATCATTTGCTGTGTTTTGACAGTTTTTAATTTGCAGTATTCACTCACGAACTGTTTTATTTTAGGAATAATGCAAAACCAACCTTC GTCCGGTGATGAGAATAGCCGTATGATAAGAGAATTTGCTCATCGTGCTTTAAATGATTAACTGTTTTACCTTATTTAGTATTTCATAGA CTTTGCATGATATGGTACACTCCTAATTATGCATTCTTTGGTTTCCAAATCTTAATCTAAGATACTTTGTTAACTGACTGGTAGCCTAAG AAAGAGACTTTTCTTCCTGTTTTTCTCTCTCCCCATTTTTTGGGGTAAGTTTTGCAAAGATCAGTGCTGCTTCTCATGACTCTAAAGTAA AGCTCTTTTGGATAGCACAGCCTAACTTTACAGCTAGACAGAATGGCCATTAAGAATATTTCCAAAATCCAAGTTTATCAAAATTATTTT GTGGGAAATCATCAATCTATTTTATTAATGTTATGTGTTTAATTTTGGACTTATTTTGGGAAAAACTGTTCAAATTGGGTCCTTTTAAGC TTATTTTAAGCAGCCTAGAAGGAAGAAGCTACTTAGCTAATGAAAGCTGAGACACTTTATTAAAAGCAGGATCTTAAGAGCATTGTTTTT CCTTAAAAACTTTATACTCTCAGATAATCTGCAACAACAAAAATTAAGAAATCCCTGACTTTTGTAGAATTCCCACTGTCAAATTCTCAC TGACTTATGAGTGTGAGAGAAGTTATCTTTTGTTTGAATTCTGATAGAACAGTTTAACTCCTTTCTAAGGATATAAAAAATTCATTGGAA AGTGTGTATATTTCAAAGACTCTCAATTATCTGGACTGAAGGCACTGTTCTCACTATGGCCAGATGAATGGGAGTATTCTGTACATGAAT CATGCTGTATTTTAAATCAGGACATCACTTAAGTATTAATGTTGTGTGTACAGATTTTTGTTTTGGGATTTTTTTTGCCTAAATAAATGT >In-frame_ENST00000379846_ENST00000294353_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(amino acids)=823AA_start in transcript=562_stop in transcript=3033 MESPQAPRSRPAMLCTSSPGYLEPAQALPWVPGQLPFPAGQVLRCGSGHGRQGGAVWPPCGLSEAVAHVEGTGRSRAGAAHRPGLCPCPE EASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLRTMAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKA FCHHKLVELDATGVNADITITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLAEVASLPRLESL DISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTD KAVEAFIQQRPSMQFVGLLATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFSLTHVMEKTKPEILKLVVTGMR NHPMNLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHED QNMQRMAVAIISILAAKLSTEQTAQLGTELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNLTDESPTTCRHFIENQGLELFMRVLESF PTESSIQQKVLGLLNNIAEVQELHSELMWKDFIDHISSLLHSVEVEVSYFAAGIIAHLISRGEQAWTLSRSQRNSLLDDLHSAILKWPTP ECEMVAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNPSRYCSMLIEEGGLQHLYNIKDHEHTDPHVQQIAVAILDSLEKHIVRHGR -------------------------------------------------------------- >In-frame_ENST00000453446_ENST00000443756_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(transcript)=3553nt_BP=1458nt ACTTCCGGGCTCGGCAGCTAGACTAGCGGGGGCAGCCTCAGAGCGGGCCGTCCAGCATCAAACACTAGCCTCCACACGTGGAAAAGACCC TGACTCCCACAGTAGACTAGTCTTATGGGAGTCCTGGCTCTTGGGCCAGGCTGCATTAGGAAAATGGAAACCAGACTGTCTTCAAATTCT TCTGCCTAGCCTTAGCCATTAGAGAGAGGTCCTGCTAAAGATGGACTGCAAATGCGCTTGATGGAAGGAGATGTCAATTCCACTGAAGTC CTCATTTCTGCTGTAGATCCTGATGGCTGACTCAGAAGCACTCCCCTCCCTTGCTGGGGACCCAGTGGCTGTGGAAGCCTTGCTCCGGGC CGTGTTTGGGGTTGTTGTGGATGAGGCCATTCAGAAAGGAACCAGTGTCTCCCAGAAGGTCTGTGAGTGGAAGGAGCCTGAGGAGCTGAA GCAGCTGCTGGATTTGGAGCTGCGGAGCCAGGGCGAGTCACAGAAGCAGATCCTGGAGCGGTGTCGGGCTGTGATTCGCTACAGTGTCAA GACTGGTCACCCTCGGTTCTTCAACCAGCTCTTCTCTGGGTTGGATCCCCATGCTCTGGCCGGGCGCATTATCACTGAGAGCCTCAACAC CAGCCAGTACACATATGAAATCGCCCCCGTGTTTGTGCTCATGGAAGAGGAGGTGCTGAGGAAACTGCGGGCCCTGGTGGGCTGGAGCTC TGGGGACGGAATCTTCTGCCCTGGTGGCTCCATCTCCAACATGTATGCTGTAAATCTGGCCCGCTATCAGCGCTACCCGGATTGCAAGCA GAGGGGCCTCCGCACACTGCCGCCCCTGGCCCTATTCACATCGAAGGAGTGTCACTACTCCATCCAGAAGGGAGCTGCGTTTCTGGGACT TGGCACCGACAGTGTCCGAGTGGTCAAGGCTGATGAGAGAGGGAAAATGGTCCCCGAGGATCTGGAGAGGCAGATTGGTATGGCCGAGGC TGAGGGTGCTGTGCCGTTCCTGGTCAGTGCCACCTCTGGCACCACTGTGCTAGGGGCCTTTGACCCCCTGGAGGCAATTGCTGATGTGTG CCAGCGTCATGGGCTATGGCTGCATGTGGATGCTGCCTGGGGTGGGAGCGTCCTGCTGTCACAGACACACAGGCATCTCCTGGATGGGAT CCAGAGGGCTGACTCTGTGGCCTGGAATCCCCACAAGCTCCTCGCAGCAGGCCTGCAATGCTCTGCACTTCTTCTCCAGGATACCTCGAA CCTGCTCAAGCGCTGCCATGGGTCCCAGGCCAGCTACCTTTTCCAGCAGGACAAGTTCTACGATGTGGCTCTGGACACGGGAGACAAGGT GGTGCAGTGTGGCCGCCGTGTGGACTGTCTGAAGCTGTGGCTCATGTGGAAGGCACAGGGCGATCAAGGGCTGGAGCGGCGCATCGACCA GGCCTTTGTCCTTGCCCGGAGGAGGCGTCTCCCTATTCCTTACTTGATATCTGCTTGAATTTCTTGACTACTCACCTTGAGAAGTTCTGT TCAGCCAGACAAGATGGAACATTGTGTCTGCAGGAACCTGGAGTATTCCCACAGGAGGTGGCTGATCGACTGCTTCGGACCATGGCTTTT CATGGTCTATTGAATGATGGAACTGTGGGTATTTTTAGGGGCAACCAGATGCGCTTAAAGCGAGCCTGCATTCGCAAAGCAAAGATCTCT GCTGTTGCTTTCCGGAAAGCTTTCTGCCACCACAAGTTAGTGGAACTTGATGCCACAGGTGTGAATGCTGATATCACGATTACAGACATT ATCAGTGGGCTTGGCAGTAACAAATGGATCCAGCAGAATCTCCAGTGCCTGGTGCTGAATTCATTAACTCTCTCCCTCGAGGATCCTTAC GAGCGCTGCTTCAGCCGGCTTTCTGGCCTTCGAGCTTTAAGCATCACGAATGTTCTCTTTTACAATGAAGACCTGGCTGAAGTTGCCTCA TTGCCAAGATTAGAGAGCTTGGATATTTCTAACACCTCAATCACAGACATCACTGCTCTACTGGCCTGCAAAGACCGACTCAAGTCTCTA ACCATGCACCACTTGAAATGTTTAAAAATGACAACTACCCAGATACTGGATGTAGTTCGGGAACTCAAACATCTGAATCATCTTGATATC TCAGATGATAAACAGTTTACATCAGACATAGCTCTTCGCTTACTAGAACAAAAAGACATCCTACCTAACCTTGTTTCTCTGGATGTTTCT GGGAGAAAGCACGTGACAGATAAAGCCGTTGAAGCCTTTATACAACAACGTCCAAGCATGCAATTTGTAGGTTTGCTGGCTACTGATGCT GGTTACTCTGAATTCCTCACAGGCGAAGGACATTTGAAGGTGTCTGGGGAAGCCAATGAAACTCAGATTGCAGAAGCACTGAAGCGTTAC AGTGAACGGGCATTCTTTGTTCGGGAAGCTCTATTTCATCTTTTTAGTCTGACTCATGTGATGGAAAAAACAAAGCCAGAAATTTTAAAG CTTGTGGTTACTGGGATGAGAAACCACCCTATGAATTTGCCAGTGCAACTGGCTGCAAGCGCCTGTGTATTTAACTTAACCAAGCAGGAT CTTGCTGCAGGGATGCCTGTCCGACTCCTGGCTGATGTGACCCATTTGCTGCTCAAAGCCATGGAACATTTTCCCAATCACCAGCAGTTA CAGAAGAATTGCCTCCTTTCACTTTGCAGTGACCGGATCCTTCAAGATGTTCCATTTAACAGGTTTGAAGCAGCCAAGCTTGTCATGCAG TGGCTTTGCAACCATGAGGATCAAAACATGCAAAGGATGGCAGTTGCTATCATTTCTATCCTGGCTGCCAAGCTTTCTACAGAACAAACT GCACAGCTTGGTACTGAGCTCTTCATTGTCAGGAACAATATAGCTGAAGTACAAGAATTACATTCTGAATTAATGTGGAAAGATTTTATA GACCACATCAGTAGTCTCCTACACAGTGTGGAAGTGGAAGTCAGTTACTTTGCAGCTGGAATTATTGCCCATTTAATATCCAGAGGTGAA CAAGCTTGGACATTGAGTCGTAGCCAGAGGAATTCTCTGCTGGATGATTTGCATTCAGCTATTTTGAAATGGCCAACTCCAGAGTGTGAG ATGGTAGCATACAGGTCCTTTAATCCATTTTTCCCATTACTTGGCTGTTTCACAACACCAGGAGTTCAGCTATGGGCAGTTTGGGCCATG CAACATGTCTGCAGCAAGAATCCTTCAAGGTATTGCAGCATGCTGATTGAAGAAGGAGGATTGCAGCATTTATACAACATCAAAGATCAT GAACATACTGATCCCCATGTCCAACAGATTGCTGTGGCCATTCTGGATAGCTTAGAAAAACACATTGTGCGCCATGGGAGGCCACCTCCC TGTAAAAAACAGCCCCAAGCCAGACTAAATTGATAGCCATAAGTATTGGATAGTTGAATCACAGGAATCCTTTTTGTGATTGGTCCATTT >In-frame_ENST00000453446_ENST00000443756_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(amino acids)=753AA_start in transcript=1191_stop in transcript=3452 MESPQAPRSRPAMLCTSSPGYLEPAQALPWVPGQLPFPAGQVLRCGSGHGRQGGAVWPPCGLSEAVAHVEGTGRSRAGAAHRPGLCPCPE EASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLRTMAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKA FCHHKLVELDATGVNADITITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLAEVASLPRLESL DISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTD KAVEAFIQQRPSMQFVGLLATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFSLTHVMEKTKPEILKLVVTGMR NHPMNLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHED QNMQRMAVAIISILAAKLSTEQTAQLGTELFIVRNNIAEVQELHSELMWKDFIDHISSLLHSVEVEVSYFAAGIIAHLISRGEQAWTLSR SQRNSLLDDLHSAILKWPTPECEMVAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNPSRYCSMLIEEGGLQHLYNIKDHEHTDPHV -------------------------------------------------------------- >In-frame_ENST00000453446_ENST00000545132_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(transcript)=3535nt_BP=1458nt ACTTCCGGGCTCGGCAGCTAGACTAGCGGGGGCAGCCTCAGAGCGGGCCGTCCAGCATCAAACACTAGCCTCCACACGTGGAAAAGACCC TGACTCCCACAGTAGACTAGTCTTATGGGAGTCCTGGCTCTTGGGCCAGGCTGCATTAGGAAAATGGAAACCAGACTGTCTTCAAATTCT TCTGCCTAGCCTTAGCCATTAGAGAGAGGTCCTGCTAAAGATGGACTGCAAATGCGCTTGATGGAAGGAGATGTCAATTCCACTGAAGTC CTCATTTCTGCTGTAGATCCTGATGGCTGACTCAGAAGCACTCCCCTCCCTTGCTGGGGACCCAGTGGCTGTGGAAGCCTTGCTCCGGGC CGTGTTTGGGGTTGTTGTGGATGAGGCCATTCAGAAAGGAACCAGTGTCTCCCAGAAGGTCTGTGAGTGGAAGGAGCCTGAGGAGCTGAA GCAGCTGCTGGATTTGGAGCTGCGGAGCCAGGGCGAGTCACAGAAGCAGATCCTGGAGCGGTGTCGGGCTGTGATTCGCTACAGTGTCAA GACTGGTCACCCTCGGTTCTTCAACCAGCTCTTCTCTGGGTTGGATCCCCATGCTCTGGCCGGGCGCATTATCACTGAGAGCCTCAACAC CAGCCAGTACACATATGAAATCGCCCCCGTGTTTGTGCTCATGGAAGAGGAGGTGCTGAGGAAACTGCGGGCCCTGGTGGGCTGGAGCTC TGGGGACGGAATCTTCTGCCCTGGTGGCTCCATCTCCAACATGTATGCTGTAAATCTGGCCCGCTATCAGCGCTACCCGGATTGCAAGCA GAGGGGCCTCCGCACACTGCCGCCCCTGGCCCTATTCACATCGAAGGAGTGTCACTACTCCATCCAGAAGGGAGCTGCGTTTCTGGGACT TGGCACCGACAGTGTCCGAGTGGTCAAGGCTGATGAGAGAGGGAAAATGGTCCCCGAGGATCTGGAGAGGCAGATTGGTATGGCCGAGGC TGAGGGTGCTGTGCCGTTCCTGGTCAGTGCCACCTCTGGCACCACTGTGCTAGGGGCCTTTGACCCCCTGGAGGCAATTGCTGATGTGTG CCAGCGTCATGGGCTATGGCTGCATGTGGATGCTGCCTGGGGTGGGAGCGTCCTGCTGTCACAGACACACAGGCATCTCCTGGATGGGAT CCAGAGGGCTGACTCTGTGGCCTGGAATCCCCACAAGCTCCTCGCAGCAGGCCTGCAATGCTCTGCACTTCTTCTCCAGGATACCTCGAA CCTGCTCAAGCGCTGCCATGGGTCCCAGGCCAGCTACCTTTTCCAGCAGGACAAGTTCTACGATGTGGCTCTGGACACGGGAGACAAGGT GGTGCAGTGTGGCCGCCGTGTGGACTGTCTGAAGCTGTGGCTCATGTGGAAGGCACAGGGCGATCAAGGGCTGGAGCGGCGCATCGACCA GGCCTTTGTCCTTGCCCGGAGGAGGCGTCTCCCTATTCCTTACTTGATATCTGCTTGAATTTCTTGACTACTCACCTTGAGAAGTTCTGT TCAGCCAGACAAGATGGAACATTGTGTCTGCAGGAACCTGGAGTATTCCCACAGGAGGTGGCTGATCGACTGCTTCGGACCATGGCTTTT CATGGTCTATTGAATGATGGAACTGTGGGTATTTTTAGGGGCAACCAGATGCGCTTAAAGCGAGCCTGCATTCGCAAAGCAAAGATCTCT GCTGTTGCTTTCCGGAAAGCTTTCTGCCACCACAAGTTAGTGGAACTTGATGCCACAGGTGTGAATGCTGATATCACGATTACAGACATT ATCAGTGGGCTTGGCAGTAACAAATGGATCCAGCAGAATCTCCAGTGCCTGGTGCTGAATTCATTAACTCTCTCCCTCGAGGATCCTTAC GAGCGCTGCTTCAGCCGGCTTTCTGGCCTTCGAGCTTTAAGCATCACGAATGTTCTCTTTTACAATGAAGACCTGGCTGAAGTTGCCTCA TTGCCAAGATTAGAGAGCTTGGATATTTCTAACACCTCAATCACAGACATCACTGCTCTACTGGCCTGCAAAGACCGACTCAAGTCTCTA ACCATGCACCACTTGAAATGTTTAAAAATGACAACTACCCAGATACTGGATGTAGTTCGGGAACTCAAACATCTGAATCATCTTGATATC TCAGATGATAAACAGTTTACATCAGACATAGCTCTTCGCTTACTAGAACAAAAAGACATCCTACCTAACCTTGTTTCTCTGGATGTTTCT GGGAGAAAGCACGTGACAGATAAAGCCGTTGAAGCCTTTATACAACAACGTCCAAGCATGCAATTTGTAGGTTTGCTGGCTACTGATGCT GGTTACTCTGAATTCCTCACAGGCGAAGGACATTTGAAGGTGTCTGGGGAAGCCAATGAAACTCAGATTGCAGAAGCACTGAAGCGTTAC AGTGAACGGGCATTCTTTGTTCGGGAAGCTCTATTTCATCTTTTTAGTCTGACTCATGTGATGGAAAAAACAAAGCCAGAAATTTTAAAG CTTGTGGTTACTGGGATGAGAAACCACCCTATGAATTTGCCAGTGCAACTGGCTGCAAGCGCCTGTGTATTTAACTTAACCAAGCAGGAT CTTGCTGCAGGGATGCCTGTCCGACTCCTGGCTGATGTGACCCATTTGCTGCTCAAAGCCATGGAACATTTTCCCAATCACCAGCAGTTA CAGAAGAATTGCCTCCTTTCACTTTGCAGTGACCGGATCCTTCAAGATGTTCCATTTAACAGGTTTGAAGCAGCCAAGCTTGTCATGCAG TGGCTTTGCAACCATGAGGATCAAAACATGCAAAGGATGGCAGTTGCTATCATTTCTATCCTGGCTGCCAAGCTTTCTACAGAACAAACT GCACAGCTTGGTACTGAGCTCTTCATTGTCAGGCAACTTCTTCAAATAGTGAAGCAGAAAACCAATCAAAATTCAGTGGACACTACATTG AAATTTACTTTGAGTGCACTTTGGAACCTCACAGATGAATCTCCAACCACTTGTAGACACTTTATTGAAAACCAAGGGTTAGAACTCTTC ATGAGGGTTCTAGAGTCTTTCCCAACTGAGTCATCCATTCAGCAGAAAGTTCTAGGACTTTTGGGTTAATATGATTATTTGATACAGAAG TTGGCTCAGGTCATCTGAAACGGAAAGAACAATATAGCTGAAGTACAAGAATTACATTCTGAATTAATGTGGAAAGATTTTATAGACCAC ATCAGTAGTCTCCTACACAGTGTGGAAGTGGAAGTCAGTTACTTTGCAGCTGGAATTATTGCCCATTTAATATCCAGAGGTGAACAAGCT TGGACATTGAGTCGTAGCCAGAGGAATTCTCTGCTGGATGATTTGCATTCAGCTATTTTGAAATGGCCAACTCCAGAGTGTGAGATGGTA GCATACAGGTCCTTTAATCCATTTTTCCCATTACTTGGCTGTTTCACAACACCAGGAGTTCAGCTATGGGCAGTTTGGGCCATGCAACAT >In-frame_ENST00000453446_ENST00000545132_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(amino acids)=645AA_start in transcript=1191_stop in transcript=3128 MESPQAPRSRPAMLCTSSPGYLEPAQALPWVPGQLPFPAGQVLRCGSGHGRQGGAVWPPCGLSEAVAHVEGTGRSRAGAAHRPGLCPCPE EASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLRTMAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKA FCHHKLVELDATGVNADITITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLAEVASLPRLESL DISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTD KAVEAFIQQRPSMQFVGLLATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFSLTHVMEKTKPEILKLVVTGMR NHPMNLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHED QNMQRMAVAIISILAAKLSTEQTAQLGTELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNLTDESPTTCRHFIENQGLELFMRVLESF -------------------------------------------------------------- >In-frame_ENST00000453446_ENST00000294353_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(transcript)=9376nt_BP=1458nt ACTTCCGGGCTCGGCAGCTAGACTAGCGGGGGCAGCCTCAGAGCGGGCCGTCCAGCATCAAACACTAGCCTCCACACGTGGAAAAGACCC TGACTCCCACAGTAGACTAGTCTTATGGGAGTCCTGGCTCTTGGGCCAGGCTGCATTAGGAAAATGGAAACCAGACTGTCTTCAAATTCT TCTGCCTAGCCTTAGCCATTAGAGAGAGGTCCTGCTAAAGATGGACTGCAAATGCGCTTGATGGAAGGAGATGTCAATTCCACTGAAGTC CTCATTTCTGCTGTAGATCCTGATGGCTGACTCAGAAGCACTCCCCTCCCTTGCTGGGGACCCAGTGGCTGTGGAAGCCTTGCTCCGGGC CGTGTTTGGGGTTGTTGTGGATGAGGCCATTCAGAAAGGAACCAGTGTCTCCCAGAAGGTCTGTGAGTGGAAGGAGCCTGAGGAGCTGAA GCAGCTGCTGGATTTGGAGCTGCGGAGCCAGGGCGAGTCACAGAAGCAGATCCTGGAGCGGTGTCGGGCTGTGATTCGCTACAGTGTCAA GACTGGTCACCCTCGGTTCTTCAACCAGCTCTTCTCTGGGTTGGATCCCCATGCTCTGGCCGGGCGCATTATCACTGAGAGCCTCAACAC CAGCCAGTACACATATGAAATCGCCCCCGTGTTTGTGCTCATGGAAGAGGAGGTGCTGAGGAAACTGCGGGCCCTGGTGGGCTGGAGCTC TGGGGACGGAATCTTCTGCCCTGGTGGCTCCATCTCCAACATGTATGCTGTAAATCTGGCCCGCTATCAGCGCTACCCGGATTGCAAGCA GAGGGGCCTCCGCACACTGCCGCCCCTGGCCCTATTCACATCGAAGGAGTGTCACTACTCCATCCAGAAGGGAGCTGCGTTTCTGGGACT TGGCACCGACAGTGTCCGAGTGGTCAAGGCTGATGAGAGAGGGAAAATGGTCCCCGAGGATCTGGAGAGGCAGATTGGTATGGCCGAGGC TGAGGGTGCTGTGCCGTTCCTGGTCAGTGCCACCTCTGGCACCACTGTGCTAGGGGCCTTTGACCCCCTGGAGGCAATTGCTGATGTGTG CCAGCGTCATGGGCTATGGCTGCATGTGGATGCTGCCTGGGGTGGGAGCGTCCTGCTGTCACAGACACACAGGCATCTCCTGGATGGGAT CCAGAGGGCTGACTCTGTGGCCTGGAATCCCCACAAGCTCCTCGCAGCAGGCCTGCAATGCTCTGCACTTCTTCTCCAGGATACCTCGAA CCTGCTCAAGCGCTGCCATGGGTCCCAGGCCAGCTACCTTTTCCAGCAGGACAAGTTCTACGATGTGGCTCTGGACACGGGAGACAAGGT GGTGCAGTGTGGCCGCCGTGTGGACTGTCTGAAGCTGTGGCTCATGTGGAAGGCACAGGGCGATCAAGGGCTGGAGCGGCGCATCGACCA GGCCTTTGTCCTTGCCCGGAGGAGGCGTCTCCCTATTCCTTACTTGATATCTGCTTGAATTTCTTGACTACTCACCTTGAGAAGTTCTGT TCAGCCAGACAAGATGGAACATTGTGTCTGCAGGAACCTGGAGTATTCCCACAGGAGGTGGCTGATCGACTGCTTCGGACCATGGCTTTT CATGGTCTATTGAATGATGGAACTGTGGGTATTTTTAGGGGCAACCAGATGCGCTTAAAGCGAGCCTGCATTCGCAAAGCAAAGATCTCT GCTGTTGCTTTCCGGAAAGCTTTCTGCCACCACAAGTTAGTGGAACTTGATGCCACAGGTGTGAATGCTGATATCACGATTACAGACATT ATCAGTGGGCTTGGCAGTAACAAATGGATCCAGCAGAATCTCCAGTGCCTGGTGCTGAATTCATTAACTCTCTCCCTCGAGGATCCTTAC GAGCGCTGCTTCAGCCGGCTTTCTGGCCTTCGAGCTTTAAGCATCACGAATGTTCTCTTTTACAATGAAGACCTGGCTGAAGTTGCCTCA TTGCCAAGATTAGAGAGCTTGGATATTTCTAACACCTCAATCACAGACATCACTGCTCTACTGGCCTGCAAAGACCGACTCAAGTCTCTA ACCATGCACCACTTGAAATGTTTAAAAATGACAACTACCCAGATACTGGATGTAGTTCGGGAACTCAAACATCTGAATCATCTTGATATC TCAGATGATAAACAGTTTACATCAGACATAGCTCTTCGCTTACTAGAACAAAAAGACATCCTACCTAACCTTGTTTCTCTGGATGTTTCT GGGAGAAAGCACGTGACAGATAAAGCCGTTGAAGCCTTTATACAACAACGTCCAAGCATGCAATTTGTAGGTTTGCTGGCTACTGATGCT GGTTACTCTGAATTCCTCACAGGCGAAGGACATTTGAAGGTGTCTGGGGAAGCCAATGAAACTCAGATTGCAGAAGCACTGAAGCGTTAC AGTGAACGGGCATTCTTTGTTCGGGAAGCTCTATTTCATCTTTTTAGTCTGACTCATGTGATGGAAAAAACAAAGCCAGAAATTTTAAAG CTTGTGGTTACTGGGATGAGAAACCACCCTATGAATTTGCCAGTGCAACTGGCTGCAAGCGCCTGTGTATTTAACTTAACCAAGCAGGAT CTTGCTGCAGGGATGCCTGTCCGACTCCTGGCTGATGTGACCCATTTGCTGCTCAAAGCCATGGAACATTTTCCCAATCACCAGCAGTTA CAGAAGAATTGCCTCCTTTCACTTTGCAGTGACCGGATCCTTCAAGATGTTCCATTTAACAGGTTTGAAGCAGCCAAGCTTGTCATGCAG TGGCTTTGCAACCATGAGGATCAAAACATGCAAAGGATGGCAGTTGCTATCATTTCTATCCTGGCTGCCAAGCTTTCTACAGAACAAACT GCACAGCTTGGTACTGAGCTCTTCATTGTCAGGCAACTTCTTCAAATAGTGAAGCAGAAAACCAATCAAAATTCAGTGGACACTACATTG AAATTTACTTTGAGTGCACTTTGGAACCTCACAGATGAATCTCCAACCACTTGTAGACACTTTATTGAAAACCAAGGGTTAGAACTCTTC ATGAGGGTTCTAGAGTCTTTCCCAACTGAGTCATCCATTCAGCAGAAAGTTCTAGGACTTTTGAACAATATAGCTGAAGTACAAGAATTA CATTCTGAATTAATGTGGAAAGATTTTATAGACCACATCAGTAGTCTCCTACACAGTGTGGAAGTGGAAGTCAGTTACTTTGCAGCTGGA ATTATTGCCCATTTAATATCCAGAGGTGAACAAGCTTGGACATTGAGTCGTAGCCAGAGGAATTCTCTGCTGGATGATTTGCATTCAGCT ATTTTGAAATGGCCAACTCCAGAGTGTGAGATGGTAGCATACAGGTCCTTTAATCCATTTTTCCCATTACTTGGCTGTTTCACAACACCA GGAGTTCAGCTATGGGCAGTTTGGGCCATGCAACATGTCTGCAGCAAGAATCCTTCAAGGTATTGCAGCATGCTGATTGAAGAAGGAGGA TTGCAGCATTTATACAACATCAAAGATCATGAACATACTGATCCCCATGTCCAACAGATTGCTGTGGCCATTCTGGATAGCTTAGAAAAA CACATTGTGCGCCATGGGAGGCCACCTCCCTGTAAAAAACAGCCCCAAGCCAGACTAAATTGATAGCCATAAGTATTGGATAGTTGAATC ACAGGAATCCTTTTTGTGATTGGTCCATTTGGAATATCTTACCCTCCCTGATGTTTTGGGGGTTTCTATGACAAGAGTCATAAAATCAGT TTGGGATTGATAATGTGTAGTACTGCCCATGTGAACAGTCTCTAATTTGTCTTGTGATTTTAAACTTATGAGTCAAGAAGGGTCTCTTCC TTTATCATTGCCTTTTAGGAAATTTTCCACATCTTTCAGTGTTTGAACTTACTTGTGCTTGAGATTCTACAGTTTTATGGTAAAGTTTGC ACGAACCCTTAGGCCAGACTTTTCTGATCTCAGAGTCCCTTCCAATCAATTTGCAGCTTCACATAAGCTGTTGACCTGATTTCTGACACT GCTTCAGTTGTAAATTTTATACTGCTTCTGTATAAAATGCCTTTCTTCTCTATCTGTGTATATTTTATAAGATGTCCTTCTTAGTGTGAA AGAAGGGAAATGTGGATCATCTTGTGGAAGCTAATCACTGGCAGGAGCCTGGATGGCTGGCGGAAAGATATATGAGAAAGAAAAATTATG AAGGTAGAACAGAGTGTAGGAACTGGGAATTGGTTTCATGGTATAGGTTTTAAAATGAGACAGGCTACCCTTCGGGAGTCCACCTCTCTT GAGGCGGTGAGCAGAAGCTTGTCCTCCATATTTATACCTAGAAGTGTGGACTGCTGGTTCCTGCACAGACTGCCGGTTATTCACTAGGAA TATTTCCCCAAGCACCACAGTATAAAATACTACAGCACTCTGTGTTAAAGACTAACTGTCTACATCTCCATATGTTGTAGTGTTGTGAAA ATGTGATTTTAAAAAATTATCGCCAGTTAAAACTGGCTATTCTTTTCCTCTATTTCAAAGTCATTTTTGTTCAGTGGAATAGAGACAGCA ACATGGTGTTAACCTCTCAATTAAAATACAATTGACACCAGTAAATTTTGCCATAAAAAGTTAAAATCTCTTGTTCAAAATATGTGTATC TTCTTAATGTGTTCATGTTAGAGAAAGTGTCCCCATCTCACTGCCAAAAATGAAAGAAAATAATTAAACTCTTTAAATGATTAAATGTAA TGATTCTACTCGCAGTGCATAACAGCACATATTTTTGACAGATTATTTTTTAGGCAATTACCTTTCCTTAAGGTATCTGATACAGTATAG TAAAGAATCACTTATATCAGTAATAGCACTTGAGAGATAGCAAGTCACCAAGAAACTTAATTTTCATTTAAAATTTTATTTTGTGAATAA GGTCAATCTACAATCCCAGATAACTACATTTTTTTTCATAGATGGCCAGTGTTTTCAACAGAGATTTAAAATGGAATATTAAAATTATAG TGATTATTCAGAAGCATTTTAATTTAGAAAGGAGCTGGTTTGTTAGTTCACTGATGACATTTTTTGACAAACATTTTATACCATTATCAC AATAATCAGACTTGAATTTTTTTTGGAGTTCCTTCATGTGAATGAAAACTGAGTTAAAAGAAAGTAGGCATTTAGGTCTGGATGCAGTGG CTCATGCTTGTAATCCCAGCACTTTGGGAAGCTGAAGCAGGAGGATTGCTTGAGCCCAGAAGTTCAAGACTAGCCTGGGCAACATAGTGA GACTCGGTCTCTACCAAAAAAAAAAATTTTTTTTTTTTAAATTAGCTGGGTGTGGTGGCACCTGGGAAACAGAGCGAGACGCTGACTCAA ATAAATATCTAAATAGATATTTAGAATCACTGAAAACCATATTAAATGCTGGGTTAATGCTGACTTAATTGGCTTAAGGAATTTTTATAG GCGTAAGATAAATTTTCACAGACTAAGTTTATTTCAGACAAAATAGAGAATTCTTTTAAAAGTTTTTTTTTTTTTTTTCCTTTTTCGAAT GTTAATGTCTAAGACAAAGTTCAGAAAACGAGATGGCCTGTGGTAGTTTGGAAATTGCTAGATATGTTGACCGTTTCCAGGTCTTTTATC TAGTGTAGTTAAGGGAAAGCCTATTTAAGAAGTTTGGCTTCAAGTTTCTGTTTTATAAGACAAAAGTGCATATTTCTTTACAGGCTAATG CTAGGTTTTTGTCTTTACAAATTATTTTCAGAAATGGCTAAAAGTGTACAGAAAACAGTAAATCCCTTCTTTACTCAGAATAACTTCTTA ATAGTTGAAGCATCCAAAATATGTAAAAGCAAGGGTGGGCGTAGTGGCTCTTGCCTGTAATCCCAGCATTCTGGGAGGCCGAGGCGGGCA GATCACTTGAGATCAGGAGTTCGAGACCACCCTGGCCAACGTGGTGAAACCCCGTCTCTACTAAAAATACAAAAACTAGCTGGGCATGGT GGCTTTTTTGCACGCCTATAGTCCCAGCTACTCGGGAGGCTGAGGCACGAGAATCACTTGAACCCAGGAAGTGGAGGTTGCAGTGAGCTA AGATCGTGCCACTGCACTCCAGCCTGGACAACGGAGTGAGACTCTGGGGAAAAAAAAAATTAAACTTCCTACTTTTTTTCTTTTTGTAGA GACAGAGTTTCACTCTGTCGCCCAAGCTGGAGTGCAGTGGCACAATCATACCTCACTGCAGCCTCTTGGGCTTATGTGATCTTACCCCCT CAGCCTCTGGAGTAGCTGGAACTACAGGCTAAATTTCCTACTTTGTAAACATCAGTAGTGGCCAGATACTTCTGAGTCTTAAAAGCATAA TAGGCCGGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACAAGGTCAGGAGTTCAAGACCAGCC TGGCCCAAATGGTGAAACCCTGTCTCTACTAAATATACAAAAATTAGCTGGGTGTGGTGGCGGGCACCTGTAATCCCAGCTACTCAGGAG GCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGTGGAGGTTGTGGTGAGCCAATATCATGCCACTGCACTCCAGCCTGGGTGACAGAGTA AGACTCCGTCTCAAAAAAAAAAAAAGCATAATAATTTATTACATCCCAAATATATAAAAATTTGAGTGCCTTTGCAGTTGGGATGGTTCC TAAAATTGCGTATAGAATTAAGGCACAGAATTGTGTGTAAGGTCCTGAATCTGGCTAAAATACAGTGGATGTATGTATTGGAATTATGAG GCATAAGTAGCCAGTATCTATAGTTAGAATCTACAAGGCCTCCTTTTTGCACCTGTAGACTAGAATATAACTGTTATTGGTGCCTTTGAG TGTTATCTCTCAGTGGCTAGAGGTGCTGTTTCAAGCACAATTTAGACTAGGGTTGAACCACTCATTGTTCAAATCATTGGTGGGCTCCAA TGTAAAATATCACTACATCAGTCCACAAGCAACATTAAGGAAATCTAAAGGAAATGGAATTTGACTTTTTAGAGTATAATGATGTTCTAG GGCATAATGAGGAAAATTTTTAAAAAATAGATTATAATGATACATATTGGTATCATTAAGACAACAGATTTGAGCAAATACAATTAAGGT GTCTTATTTTTTGCATCAAGTAATTATTGCTGTGGTCTTTCTACTCCACAAAATAATTTTTTCTTTTTGCAGTTGAAAATTAACTGCATT ATTAACTAATTAATAAAATAAATCAAGTGGTATAAGGGATTAGTTTACCCTCAAGCCGATGACTCCATGGCTACTGATATTAGTTAGTTT AGGATTTTTAAAAAGCATATCAGACCCCCAGTTTCAGGAATTGAGTATAAATATTGCTTCTTGTCACCCTGGGACAGTAATGCCTTATAG TGGCACTAGTCACCTTAAGTAGATTACACATGGTTGAGGTGAATAAAGCTGCATGGGAATTTGCTTTCGTGATATATTTCATTTGCAAAC TTCTACATAATCAAGTTTTATGTTTAAAACCATCGGTTCTATATATCTAGCTTTAGGAAGTTGCCCTTACAGGTGGGACCTTTTGTGTTA ATCTGTTTTCTCCCCAGTCATCTTATTTGGCTATGTTAAAAAAAAAAAAAAAAAAAAAGCGAGAGAGAGAGATGGTGTCTCACTGTGTTG CCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTGACTTTCCCACCTCAGCTTCCCAAAGTGCTGGAATCACAGGCATGAGCCACAGTGCCT GGTCTTAGCTGTGTTTTTAATTATGCCATGCATCAACATAACACCGGGCCATCTTCCTATCCCTTCCTATCCCATATGTTTAATGAAAAC ATATTTTATGTGCTAAATTAGGTTAATTTACCAGAGATTTAGCTTAGTGTTTTTAAACTATAGAACAATACCCCTATAGAACAATGTACA GCTGCACCCAAGGTTAAAAAGAGGTAGCAGGGAAAACAAACTTAAACTCTTTGTATATGGTGAAACCCATCCCTCTCCTGCCCTCTAATG GTATGTTTACATTATTTCGTTATTATACAATGTAGTGGTATAAACAGTATTATTAAACTGAAGGCATAAGTTAAAGGAAGTATGTTACTT TGAGCTGATGTAGGCTCTTCCACTTTTATCTGTATTTTACTTATTTGGGGACTTTGTATTGCTAGGGCTTCAGAATACTAACTTTGACAC AGCTCCCAGAGAGGTTTGCAAACTTTTGGTTTCCCTCTCAAATCCATGGTAGTAGTTTCAAATGAGTTTGTGGATAATGGATGTTTAGTC CTTATCATTTGCTGTGTTTTGACAGTTTTTAATTTGCAGTATTCACTCACGAACTGTTTTATTTTAGGAATAATGCAAAACCAACCTTCG TCCGGTGATGAGAATAGCCGTATGATAAGAGAATTTGCTCATCGTGCTTTAAATGATTAACTGTTTTACCTTATTTAGTATTTCATAGAC TTTGCATGATATGGTACACTCCTAATTATGCATTCTTTGGTTTCCAAATCTTAATCTAAGATACTTTGTTAACTGACTGGTAGCCTAAGA AAGAGACTTTTCTTCCTGTTTTTCTCTCTCCCCATTTTTTGGGGTAAGTTTTGCAAAGATCAGTGCTGCTTCTCATGACTCTAAAGTAAA GCTCTTTTGGATAGCACAGCCTAACTTTACAGCTAGACAGAATGGCCATTAAGAATATTTCCAAAATCCAAGTTTATCAAAATTATTTTG TGGGAAATCATCAATCTATTTTATTAATGTTATGTGTTTAATTTTGGACTTATTTTGGGAAAAACTGTTCAAATTGGGTCCTTTTAAGCT TATTTTAAGCAGCCTAGAAGGAAGAAGCTACTTAGCTAATGAAAGCTGAGACACTTTATTAAAAGCAGGATCTTAAGAGCATTGTTTTTC CTTAAAAACTTTATACTCTCAGATAATCTGCAACAACAAAAATTAAGAAATCCCTGACTTTTGTAGAATTCCCACTGTCAAATTCTCACT GACTTATGAGTGTGAGAGAAGTTATCTTTTGTTTGAATTCTGATAGAACAGTTTAACTCCTTTCTAAGGATATAAAAAATTCATTGGAAA GTGTGTATATTTCAAAGACTCTCAATTATCTGGACTGAAGGCACTGTTCTCACTATGGCCAGATGAATGGGAGTATTCTGTACATGAATC ATGCTGTATTTTAAATCAGGACATCACTTAAGTATTAATGTTGTGTGTACAGATTTTTGTTTTGGGATTTTTTTTGCCTAAATAAATGTT >In-frame_ENST00000453446_ENST00000294353_TCGA-B6-A0IQ-01A_CSAD_chr12_53553904_-_ZYG11B_chr1_53222130_length(amino acids)=823AA_start in transcript=1191_stop in transcript=3662 MESPQAPRSRPAMLCTSSPGYLEPAQALPWVPGQLPFPAGQVLRCGSGHGRQGGAVWPPCGLSEAVAHVEGTGRSRAGAAHRPGLCPCPE EASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLRTMAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKA FCHHKLVELDATGVNADITITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLAEVASLPRLESL DISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTD KAVEAFIQQRPSMQFVGLLATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFSLTHVMEKTKPEILKLVVTGMR NHPMNLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHED QNMQRMAVAIISILAAKLSTEQTAQLGTELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNLTDESPTTCRHFIENQGLELFMRVLESF PTESSIQQKVLGLLNNIAEVQELHSELMWKDFIDHISSLLHSVEVEVSYFAAGIIAHLISRGEQAWTLSRSQRNSLLDDLHSAILKWPTP ECEMVAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNPSRYCSMLIEEGGLQHLYNIKDHEHTDPHVQQIAVAILDSLEKHIVRHGR -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CSAD-ZYG11B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CSAD-ZYG11B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | CSAD | Q9Y600 | DB00114 | Pyridoxal phosphate | Cofactor | Small molecule | Approved|Investigational|Nutraceutical |
| Hgene | CSAD | Q9Y600 | DB00114 | Pyridoxal phosphate | Cofactor | Small molecule | Approved|Investigational|Nutraceutical |
| Hgene | CSAD | Q9Y600 | DB00151 | Cysteine | Small molecule | Approved|Nutraceutical | |
| Hgene | CSAD | Q9Y600 | DB00151 | Cysteine | Small molecule | Approved|Nutraceutical |
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Related Diseases for CSAD-ZYG11B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CSAD | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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