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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CSNK1D-SCPEP1 (FusionGDB2 ID:19825)

Fusion Gene Summary for CSNK1D-SCPEP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CSNK1D-SCPEP1
Fusion gene ID: 19825
HgeneTgene
Gene symbol

CSNK1D

SCPEP1

Gene ID

1453

59342

Gene namecasein kinase 1 deltaserine carboxypeptidase 1
SynonymsASPS|CKI-delta|CKId|CKIdelta|FASPS2|HCKIDHSCP1|RISC
Cytomap

17q25.3

17q22

Type of geneprotein-codingprotein-coding
Descriptioncasein kinase I isoform deltacasein kinase Itau-protein kinase CSNK1Dretinoid-inducible serine carboxypeptidaseserine carboxypeptidase 1 precursor protein
Modification date2020031320200313
UniProtAcc

P48730

.
Ensembl transtripts involved in fusion geneENST00000398519, ENST00000314028, 
ENST00000392334, ENST00000578904, 
ENST00000262288, ENST00000571898, 
Fusion gene scores* DoF score17 X 16 X 13=35366 X 7 X 5=210
# samples 247
** MAII scorelog2(24/3536*10)=-3.88101196378291
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CSNK1D [Title/Abstract] AND SCPEP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCSNK1D(80231182)-SCPEP1(55072868), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSNK1D

GO:0006468

protein phosphorylation

16618118

HgeneCSNK1D

GO:0018105

peptidyl-serine phosphorylation

25500533

HgeneCSNK1D

GO:0051225

spindle assembly

10826492


check buttonFusion gene breakpoints across CSNK1D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SCPEP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2783-01ACSNK1Dchr17

80231182

-SCPEP1chr17

55072868

+
ChimerDB4LUSCTCGA-66-2783CSNK1Dchr17

80231181

-SCPEP1chr17

55072867

+
ChimerDB4LUSCTCGA-66-2783CSNK1Dchr17

80231182

-SCPEP1chr17

55072868

+
ChimerDB4LUSCTCGA-66-2783-01ACSNK1Dchr17

80231182

-SCPEP1chr17

55072868

+


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Fusion Gene ORF analysis for CSNK1D-SCPEP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000398519ENST00000262288CSNK1Dchr17

80231182

-SCPEP1chr17

55072868

+
5CDS-intronENST00000398519ENST00000571898CSNK1Dchr17

80231182

-SCPEP1chr17

55072868

+
In-frameENST00000314028ENST00000262288CSNK1Dchr17

80231182

-SCPEP1chr17

55072868

+
5CDS-intronENST00000314028ENST00000571898CSNK1Dchr17

80231182

-SCPEP1chr17

55072868

+
In-frameENST00000392334ENST00000262288CSNK1Dchr17

80231182

-SCPEP1chr17

55072868

+
5CDS-intronENST00000392334ENST00000571898CSNK1Dchr17

80231182

-SCPEP1chr17

55072868

+
intron-3CDSENST00000578904ENST00000262288CSNK1Dchr17

80231182

-SCPEP1chr17

55072868

+
intron-intronENST00000578904ENST00000571898CSNK1Dchr17

80231182

-SCPEP1chr17

55072868

+
In-frameENST00000398519ENST00000262288CSNK1Dchr17

80231181

-SCPEP1chr17

55072867

+
5CDS-intronENST00000398519ENST00000571898CSNK1Dchr17

80231181

-SCPEP1chr17

55072867

+
In-frameENST00000314028ENST00000262288CSNK1Dchr17

80231181

-SCPEP1chr17

55072867

+
5CDS-intronENST00000314028ENST00000571898CSNK1Dchr17

80231181

-SCPEP1chr17

55072867

+
In-frameENST00000392334ENST00000262288CSNK1Dchr17

80231181

-SCPEP1chr17

55072867

+
5CDS-intronENST00000392334ENST00000571898CSNK1Dchr17

80231181

-SCPEP1chr17

55072867

+
intron-3CDSENST00000578904ENST00000262288CSNK1Dchr17

80231181

-SCPEP1chr17

55072867

+
intron-intronENST00000578904ENST00000571898CSNK1Dchr17

80231181

-SCPEP1chr17

55072867

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398519CSNK1Dchr1780231182-ENST00000262288SCPEP1chr1755072868+1353123144824226
ENST00000314028CSNK1Dchr1780231182-ENST00000262288SCPEP1chr1755072868+16564264471127226
ENST00000392334CSNK1Dchr1780231182-ENST00000262288SCPEP1chr1755072868+16223924131093226
ENST00000398519CSNK1Dchr1780231181-ENST00000262288SCPEP1chr1755072867+1353123144824226
ENST00000314028CSNK1Dchr1780231181-ENST00000262288SCPEP1chr1755072867+16564264471127226
ENST00000392334CSNK1Dchr1780231181-ENST00000262288SCPEP1chr1755072867+16223924131093226

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398519ENST00000262288CSNK1Dchr1780231182-SCPEP1chr1755072868+0.0063297170.9936702
ENST00000314028ENST00000262288CSNK1Dchr1780231182-SCPEP1chr1755072868+0.0059221980.9940778
ENST00000392334ENST00000262288CSNK1Dchr1780231182-SCPEP1chr1755072868+0.0064655040.99353445
ENST00000398519ENST00000262288CSNK1Dchr1780231181-SCPEP1chr1755072867+0.0063297170.9936702
ENST00000314028ENST00000262288CSNK1Dchr1780231181-SCPEP1chr1755072867+0.0059221980.9940778
ENST00000392334ENST00000262288CSNK1Dchr1780231181-SCPEP1chr1755072867+0.0064655040.99353445

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Fusion Genomic Features for CSNK1D-SCPEP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CSNK1Dchr1780231181-SCPEP1chr1755072867+2.26E-081
CSNK1Dchr1780231181-SCPEP1chr1755072867+2.26E-081
CSNK1Dchr1780231181-SCPEP1chr1755072867+2.26E-081
CSNK1Dchr1780231181-SCPEP1chr1755072867+2.26E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CSNK1D-SCPEP1


check button Go to

FGviewer for the breakpoints of chr17:80231182-chr17:55072868

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSNK1D

P48730

.
FUNCTION: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:19339517, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSNK1Dchr17:80231181chr17:55072867ENST00000314028-1915_2325.333333333333332416.0Nucleotide bindingATP
HgeneCSNK1Dchr17:80231181chr17:55072867ENST00000392334-11015_2325.333333333333332420.3333333333333Nucleotide bindingATP
HgeneCSNK1Dchr17:80231182chr17:55072868ENST00000314028-1915_2325.333333333333332416.0Nucleotide bindingATP
HgeneCSNK1Dchr17:80231182chr17:55072868ENST00000392334-11015_2325.333333333333332420.3333333333333Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSNK1Dchr17:80231181chr17:55072867ENST00000314028-199_27725.333333333333332416.0DomainProtein kinase
HgeneCSNK1Dchr17:80231181chr17:55072867ENST00000392334-1109_27725.333333333333332420.3333333333333DomainProtein kinase
HgeneCSNK1Dchr17:80231182chr17:55072868ENST00000314028-199_27725.333333333333332416.0DomainProtein kinase
HgeneCSNK1Dchr17:80231182chr17:55072868ENST00000392334-1109_27725.333333333333332420.3333333333333DomainProtein kinase
HgeneCSNK1Dchr17:80231181chr17:55072867ENST00000314028-19278_36425.333333333333332416.0RegionNote=Centrosomal localization signal (CLS)
HgeneCSNK1Dchr17:80231181chr17:55072867ENST00000314028-19317_34225.333333333333332416.0RegionAutoinhibitory
HgeneCSNK1Dchr17:80231181chr17:55072867ENST00000392334-110278_36425.333333333333332420.3333333333333RegionNote=Centrosomal localization signal (CLS)
HgeneCSNK1Dchr17:80231181chr17:55072867ENST00000392334-110317_34225.333333333333332420.3333333333333RegionAutoinhibitory
HgeneCSNK1Dchr17:80231182chr17:55072868ENST00000314028-19278_36425.333333333333332416.0RegionNote=Centrosomal localization signal (CLS)
HgeneCSNK1Dchr17:80231182chr17:55072868ENST00000314028-19317_34225.333333333333332416.0RegionAutoinhibitory
HgeneCSNK1Dchr17:80231182chr17:55072868ENST00000392334-110278_36425.333333333333332420.3333333333333RegionNote=Centrosomal localization signal (CLS)
HgeneCSNK1Dchr17:80231182chr17:55072868ENST00000392334-110317_34225.333333333333332420.3333333333333RegionAutoinhibitory


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Fusion Gene Sequence for CSNK1D-SCPEP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000398519_ENST00000262288_TCGA-66-2783-01A_CSNK1D_chr17_80231182_-_SCPEP1_chr17_55072868_length(transcript)=1353nt_BP=123nt
CCCAGGAAGCGGCCGGGAGGGCAGGAGCGAATCGGGCCGCCGCCGCCATGGAGCTGAGAGTCGGGAACAGGTACCGGCTGGGCCGGAAGA
TCGGCAGCGGCTCCTTCGGAGACATCTATCTCGTCTCTTCTCGAAGACAAAGGTCTGGCAGAGGTGTCTAAGGTTGCAGAGCAAGTACTG
AATGCCGTAAATAAGGGGCTCTACAGAGAGGCCACAGAGCTGTGGGGGAAAGCAGAAATGATCATTGAACAGAACACAGATGGGGTGAAC
TTCTATAACATCTTAACTAAAAGCACTCCCACGTCTACAATGGAGTCGAGTCTAGAATTCACACAGAGCCACCTAGTTTGTCTTTGTCAG
CGCCACGTGAGACACCTACAACGAGATGCCTTAAGCCAGCTCATGAATGGCCCCATCAGAAAGAAGCTCAAAATTATTCCTGAGGATCAA
TCCTGGGGAGGCCAGGCTACCAACGTCTTTGTGAACATGGAGGAGGACTTCATGAAGCCAGTCATTAGCATTGTGGACGAGTTGCTGGAG
GCAGGGATCAACGTGACGGTGTATAATGGACAGCTGGATCTCATCGTAGATACCATGGGTCAGGAGGCCTGGGTGCGGAAACTGAAGTGG
CCAGAACTGCCTAAATTCAGTCAGCTGAAGTGGAAGGCCCTGTACAGTGACCCTAAATCTTTGGAAACATCTGCTTTTGTCAAGTCCTAC
AAGAACCTTGCTTTCTACTGGATTCTGAAAGCTGGTCATATGGTTCCTTCTGACCAAGGGGACATGGCTCTGAAGATGATGAGACTGGTG
ACTCAGCAAGAATAGGATGGATGGGGCTGGAGATGAGCTGGTTTGGCCTTGGGGCACAGAGCTGAGCTGAGGCCGCTGAAGCTGTAGGAA
GCGCCATTCTTCCCTGTATCTAACTGGGGCTGTGATCAAGAAGGTTCTGACCAGCTTCTGCAGAGGATAAAATCATTGTCTCTGGAGGCA
ATTTGGAAATTATTTCTGCTTCTTAAAAAAACCTAAGATTTTTTAAAAAATTGATTTGTTTTGATCAAAATAAAGGATGATAATAGATAT
TATTTTTTCTTATGACAGAAGCAAATGATGTGATTTATAGAAAAACTGGGAAATACAGGTACCCAAAGAGTAAATCAACATCTGTATACC
CCCTTCCCAGGGGTAAGCACTGTTACCAATTTAGCATATGTCCTTGCAGAATTTTTTTTTCTATATATACATATATATTTTTTACCAAAA
TGAATCATTACTCTATGTTGTTTTACTATTTGTTTGACATATCAGTATATCTGAAACACCTTTTCATGTCAATAAATGTTCTTCTCTAAC

>In-frame_ENST00000398519_ENST00000262288_TCGA-66-2783-01A_CSNK1D_chr17_80231182_-_SCPEP1_chr17_55072868_length(amino acids)=226AA_start in transcript=144_stop in transcript=824
MAEVSKVAEQVLNAVNKGLYREATELWGKAEMIIEQNTDGVNFYNILTKSTPTSTMESSLEFTQSHLVCLCQRHVRHLQRDALSQLMNGP
IRKKLKIIPEDQSWGGQATNVFVNMEEDFMKPVISIVDELLEAGINVTVYNGQLDLIVDTMGQEAWVRKLKWPELPKFSQLKWKALYSDP

--------------------------------------------------------------
>In-frame_ENST00000314028_ENST00000262288_TCGA-66-2783-01A_CSNK1D_chr17_80231182_-_SCPEP1_chr17_55072868_length(transcript)=1656nt_BP=426nt
GCCCCGCCGGGTTGCTAGGGGAAGTGACGTCACAGCGCGATGGCGGCGGCTCCTTTAGGCAGCTGAAAGGGGATTTAGGCCCGGAAGATC
CGAGTCCATCCGCGGCGGGGAGAGGGCAAGCGGGACCGGTAGGGGCCGGAGCAGCGGCGGCGGCGCTCGGACTGTCCCATCCGCCCCGTA
TTGAGGCGCTGGGAGCGGCGGGGCGACAGGAAAGCGATGGTGAAAGCGGGGCCGTGAGGGGGGCGGAGCCGGGAGCCGGACCCGCAGTAG
CGGCAGCAGCGGCGCCGCCTCCCAGAGTTCAGACCCAGGAAGCGGCCGGGAGGGCAGGAGCGAATCGGGCCGCCGCCGCCATGGAGCTGA
GAGTCGGGAACAGGTACCGGCTGGGCCGGAAGATCGGCAGCGGCTCCTTCGGAGACATCTATCTCGTCTCTTCTCGAAGACAAAGGTCTG
GCAGAGGTGTCTAAGGTTGCAGAGCAAGTACTGAATGCCGTAAATAAGGGGCTCTACAGAGAGGCCACAGAGCTGTGGGGGAAAGCAGAA
ATGATCATTGAACAGAACACAGATGGGGTGAACTTCTATAACATCTTAACTAAAAGCACTCCCACGTCTACAATGGAGTCGAGTCTAGAA
TTCACACAGAGCCACCTAGTTTGTCTTTGTCAGCGCCACGTGAGACACCTACAACGAGATGCCTTAAGCCAGCTCATGAATGGCCCCATC
AGAAAGAAGCTCAAAATTATTCCTGAGGATCAATCCTGGGGAGGCCAGGCTACCAACGTCTTTGTGAACATGGAGGAGGACTTCATGAAG
CCAGTCATTAGCATTGTGGACGAGTTGCTGGAGGCAGGGATCAACGTGACGGTGTATAATGGACAGCTGGATCTCATCGTAGATACCATG
GGTCAGGAGGCCTGGGTGCGGAAACTGAAGTGGCCAGAACTGCCTAAATTCAGTCAGCTGAAGTGGAAGGCCCTGTACAGTGACCCTAAA
TCTTTGGAAACATCTGCTTTTGTCAAGTCCTACAAGAACCTTGCTTTCTACTGGATTCTGAAAGCTGGTCATATGGTTCCTTCTGACCAA
GGGGACATGGCTCTGAAGATGATGAGACTGGTGACTCAGCAAGAATAGGATGGATGGGGCTGGAGATGAGCTGGTTTGGCCTTGGGGCAC
AGAGCTGAGCTGAGGCCGCTGAAGCTGTAGGAAGCGCCATTCTTCCCTGTATCTAACTGGGGCTGTGATCAAGAAGGTTCTGACCAGCTT
CTGCAGAGGATAAAATCATTGTCTCTGGAGGCAATTTGGAAATTATTTCTGCTTCTTAAAAAAACCTAAGATTTTTTAAAAAATTGATTT
GTTTTGATCAAAATAAAGGATGATAATAGATATTATTTTTTCTTATGACAGAAGCAAATGATGTGATTTATAGAAAAACTGGGAAATACA
GGTACCCAAAGAGTAAATCAACATCTGTATACCCCCTTCCCAGGGGTAAGCACTGTTACCAATTTAGCATATGTCCTTGCAGAATTTTTT
TTTCTATATATACATATATATTTTTTACCAAAATGAATCATTACTCTATGTTGTTTTACTATTTGTTTGACATATCAGTATATCTGAAAC

>In-frame_ENST00000314028_ENST00000262288_TCGA-66-2783-01A_CSNK1D_chr17_80231182_-_SCPEP1_chr17_55072868_length(amino acids)=226AA_start in transcript=447_stop in transcript=1127
MAEVSKVAEQVLNAVNKGLYREATELWGKAEMIIEQNTDGVNFYNILTKSTPTSTMESSLEFTQSHLVCLCQRHVRHLQRDALSQLMNGP
IRKKLKIIPEDQSWGGQATNVFVNMEEDFMKPVISIVDELLEAGINVTVYNGQLDLIVDTMGQEAWVRKLKWPELPKFSQLKWKALYSDP

--------------------------------------------------------------
>In-frame_ENST00000392334_ENST00000262288_TCGA-66-2783-01A_CSNK1D_chr17_80231182_-_SCPEP1_chr17_55072868_length(transcript)=1622nt_BP=392nt
GCGCGATGGCGGCGGCTCCTTTAGGCAGCTGAAAGGGGATTTAGGCCCGGAAGATCCGAGTCCATCCGCGGCGGGGAGAGGGCAAGCGGG
ACCGGTAGGGGCCGGAGCAGCGGCGGCGGCGCTCGGACTGTCCCATCCGCCCCGTATTGAGGCGCTGGGAGCGGCGGGGCGACAGGAAAG
CGATGGTGAAAGCGGGGCCGTGAGGGGGGCGGAGCCGGGAGCCGGACCCGCAGTAGCGGCAGCAGCGGCGCCGCCTCCCAGAGTTCAGAC
CCAGGAAGCGGCCGGGAGGGCAGGAGCGAATCGGGCCGCCGCCGCCATGGAGCTGAGAGTCGGGAACAGGTACCGGCTGGGCCGGAAGAT
CGGCAGCGGCTCCTTCGGAGACATCTATCTCGTCTCTTCTCGAAGACAAAGGTCTGGCAGAGGTGTCTAAGGTTGCAGAGCAAGTACTGA
ATGCCGTAAATAAGGGGCTCTACAGAGAGGCCACAGAGCTGTGGGGGAAAGCAGAAATGATCATTGAACAGAACACAGATGGGGTGAACT
TCTATAACATCTTAACTAAAAGCACTCCCACGTCTACAATGGAGTCGAGTCTAGAATTCACACAGAGCCACCTAGTTTGTCTTTGTCAGC
GCCACGTGAGACACCTACAACGAGATGCCTTAAGCCAGCTCATGAATGGCCCCATCAGAAAGAAGCTCAAAATTATTCCTGAGGATCAAT
CCTGGGGAGGCCAGGCTACCAACGTCTTTGTGAACATGGAGGAGGACTTCATGAAGCCAGTCATTAGCATTGTGGACGAGTTGCTGGAGG
CAGGGATCAACGTGACGGTGTATAATGGACAGCTGGATCTCATCGTAGATACCATGGGTCAGGAGGCCTGGGTGCGGAAACTGAAGTGGC
CAGAACTGCCTAAATTCAGTCAGCTGAAGTGGAAGGCCCTGTACAGTGACCCTAAATCTTTGGAAACATCTGCTTTTGTCAAGTCCTACA
AGAACCTTGCTTTCTACTGGATTCTGAAAGCTGGTCATATGGTTCCTTCTGACCAAGGGGACATGGCTCTGAAGATGATGAGACTGGTGA
CTCAGCAAGAATAGGATGGATGGGGCTGGAGATGAGCTGGTTTGGCCTTGGGGCACAGAGCTGAGCTGAGGCCGCTGAAGCTGTAGGAAG
CGCCATTCTTCCCTGTATCTAACTGGGGCTGTGATCAAGAAGGTTCTGACCAGCTTCTGCAGAGGATAAAATCATTGTCTCTGGAGGCAA
TTTGGAAATTATTTCTGCTTCTTAAAAAAACCTAAGATTTTTTAAAAAATTGATTTGTTTTGATCAAAATAAAGGATGATAATAGATATT
ATTTTTTCTTATGACAGAAGCAAATGATGTGATTTATAGAAAAACTGGGAAATACAGGTACCCAAAGAGTAAATCAACATCTGTATACCC
CCTTCCCAGGGGTAAGCACTGTTACCAATTTAGCATATGTCCTTGCAGAATTTTTTTTTCTATATATACATATATATTTTTTACCAAAAT
GAATCATTACTCTATGTTGTTTTACTATTTGTTTGACATATCAGTATATCTGAAACACCTTTTCATGTCAATAAATGTTCTTCTCTAACA

>In-frame_ENST00000392334_ENST00000262288_TCGA-66-2783-01A_CSNK1D_chr17_80231182_-_SCPEP1_chr17_55072868_length(amino acids)=226AA_start in transcript=413_stop in transcript=1093
MAEVSKVAEQVLNAVNKGLYREATELWGKAEMIIEQNTDGVNFYNILTKSTPTSTMESSLEFTQSHLVCLCQRHVRHLQRDALSQLMNGP
IRKKLKIIPEDQSWGGQATNVFVNMEEDFMKPVISIVDELLEAGINVTVYNGQLDLIVDTMGQEAWVRKLKWPELPKFSQLKWKALYSDP

--------------------------------------------------------------
>In-frame_ENST00000398519_ENST00000262288_TCGA-66-2783_CSNK1D_chr17_80231181_-_SCPEP1_chr17_55072867_length(transcript)=1353nt_BP=123nt
CCCAGGAAGCGGCCGGGAGGGCAGGAGCGAATCGGGCCGCCGCCGCCATGGAGCTGAGAGTCGGGAACAGGTACCGGCTGGGCCGGAAGA
TCGGCAGCGGCTCCTTCGGAGACATCTATCTCGTCTCTTCTCGAAGACAAAGGTCTGGCAGAGGTGTCTAAGGTTGCAGAGCAAGTACTG
AATGCCGTAAATAAGGGGCTCTACAGAGAGGCCACAGAGCTGTGGGGGAAAGCAGAAATGATCATTGAACAGAACACAGATGGGGTGAAC
TTCTATAACATCTTAACTAAAAGCACTCCCACGTCTACAATGGAGTCGAGTCTAGAATTCACACAGAGCCACCTAGTTTGTCTTTGTCAG
CGCCACGTGAGACACCTACAACGAGATGCCTTAAGCCAGCTCATGAATGGCCCCATCAGAAAGAAGCTCAAAATTATTCCTGAGGATCAA
TCCTGGGGAGGCCAGGCTACCAACGTCTTTGTGAACATGGAGGAGGACTTCATGAAGCCAGTCATTAGCATTGTGGACGAGTTGCTGGAG
GCAGGGATCAACGTGACGGTGTATAATGGACAGCTGGATCTCATCGTAGATACCATGGGTCAGGAGGCCTGGGTGCGGAAACTGAAGTGG
CCAGAACTGCCTAAATTCAGTCAGCTGAAGTGGAAGGCCCTGTACAGTGACCCTAAATCTTTGGAAACATCTGCTTTTGTCAAGTCCTAC
AAGAACCTTGCTTTCTACTGGATTCTGAAAGCTGGTCATATGGTTCCTTCTGACCAAGGGGACATGGCTCTGAAGATGATGAGACTGGTG
ACTCAGCAAGAATAGGATGGATGGGGCTGGAGATGAGCTGGTTTGGCCTTGGGGCACAGAGCTGAGCTGAGGCCGCTGAAGCTGTAGGAA
GCGCCATTCTTCCCTGTATCTAACTGGGGCTGTGATCAAGAAGGTTCTGACCAGCTTCTGCAGAGGATAAAATCATTGTCTCTGGAGGCA
ATTTGGAAATTATTTCTGCTTCTTAAAAAAACCTAAGATTTTTTAAAAAATTGATTTGTTTTGATCAAAATAAAGGATGATAATAGATAT
TATTTTTTCTTATGACAGAAGCAAATGATGTGATTTATAGAAAAACTGGGAAATACAGGTACCCAAAGAGTAAATCAACATCTGTATACC
CCCTTCCCAGGGGTAAGCACTGTTACCAATTTAGCATATGTCCTTGCAGAATTTTTTTTTCTATATATACATATATATTTTTTACCAAAA
TGAATCATTACTCTATGTTGTTTTACTATTTGTTTGACATATCAGTATATCTGAAACACCTTTTCATGTCAATAAATGTTCTTCTCTAAC

>In-frame_ENST00000398519_ENST00000262288_TCGA-66-2783_CSNK1D_chr17_80231181_-_SCPEP1_chr17_55072867_length(amino acids)=226AA_start in transcript=144_stop in transcript=824
MAEVSKVAEQVLNAVNKGLYREATELWGKAEMIIEQNTDGVNFYNILTKSTPTSTMESSLEFTQSHLVCLCQRHVRHLQRDALSQLMNGP
IRKKLKIIPEDQSWGGQATNVFVNMEEDFMKPVISIVDELLEAGINVTVYNGQLDLIVDTMGQEAWVRKLKWPELPKFSQLKWKALYSDP

--------------------------------------------------------------
>In-frame_ENST00000314028_ENST00000262288_TCGA-66-2783_CSNK1D_chr17_80231181_-_SCPEP1_chr17_55072867_length(transcript)=1656nt_BP=426nt
GCCCCGCCGGGTTGCTAGGGGAAGTGACGTCACAGCGCGATGGCGGCGGCTCCTTTAGGCAGCTGAAAGGGGATTTAGGCCCGGAAGATC
CGAGTCCATCCGCGGCGGGGAGAGGGCAAGCGGGACCGGTAGGGGCCGGAGCAGCGGCGGCGGCGCTCGGACTGTCCCATCCGCCCCGTA
TTGAGGCGCTGGGAGCGGCGGGGCGACAGGAAAGCGATGGTGAAAGCGGGGCCGTGAGGGGGGCGGAGCCGGGAGCCGGACCCGCAGTAG
CGGCAGCAGCGGCGCCGCCTCCCAGAGTTCAGACCCAGGAAGCGGCCGGGAGGGCAGGAGCGAATCGGGCCGCCGCCGCCATGGAGCTGA
GAGTCGGGAACAGGTACCGGCTGGGCCGGAAGATCGGCAGCGGCTCCTTCGGAGACATCTATCTCGTCTCTTCTCGAAGACAAAGGTCTG
GCAGAGGTGTCTAAGGTTGCAGAGCAAGTACTGAATGCCGTAAATAAGGGGCTCTACAGAGAGGCCACAGAGCTGTGGGGGAAAGCAGAA
ATGATCATTGAACAGAACACAGATGGGGTGAACTTCTATAACATCTTAACTAAAAGCACTCCCACGTCTACAATGGAGTCGAGTCTAGAA
TTCACACAGAGCCACCTAGTTTGTCTTTGTCAGCGCCACGTGAGACACCTACAACGAGATGCCTTAAGCCAGCTCATGAATGGCCCCATC
AGAAAGAAGCTCAAAATTATTCCTGAGGATCAATCCTGGGGAGGCCAGGCTACCAACGTCTTTGTGAACATGGAGGAGGACTTCATGAAG
CCAGTCATTAGCATTGTGGACGAGTTGCTGGAGGCAGGGATCAACGTGACGGTGTATAATGGACAGCTGGATCTCATCGTAGATACCATG
GGTCAGGAGGCCTGGGTGCGGAAACTGAAGTGGCCAGAACTGCCTAAATTCAGTCAGCTGAAGTGGAAGGCCCTGTACAGTGACCCTAAA
TCTTTGGAAACATCTGCTTTTGTCAAGTCCTACAAGAACCTTGCTTTCTACTGGATTCTGAAAGCTGGTCATATGGTTCCTTCTGACCAA
GGGGACATGGCTCTGAAGATGATGAGACTGGTGACTCAGCAAGAATAGGATGGATGGGGCTGGAGATGAGCTGGTTTGGCCTTGGGGCAC
AGAGCTGAGCTGAGGCCGCTGAAGCTGTAGGAAGCGCCATTCTTCCCTGTATCTAACTGGGGCTGTGATCAAGAAGGTTCTGACCAGCTT
CTGCAGAGGATAAAATCATTGTCTCTGGAGGCAATTTGGAAATTATTTCTGCTTCTTAAAAAAACCTAAGATTTTTTAAAAAATTGATTT
GTTTTGATCAAAATAAAGGATGATAATAGATATTATTTTTTCTTATGACAGAAGCAAATGATGTGATTTATAGAAAAACTGGGAAATACA
GGTACCCAAAGAGTAAATCAACATCTGTATACCCCCTTCCCAGGGGTAAGCACTGTTACCAATTTAGCATATGTCCTTGCAGAATTTTTT
TTTCTATATATACATATATATTTTTTACCAAAATGAATCATTACTCTATGTTGTTTTACTATTTGTTTGACATATCAGTATATCTGAAAC

>In-frame_ENST00000314028_ENST00000262288_TCGA-66-2783_CSNK1D_chr17_80231181_-_SCPEP1_chr17_55072867_length(amino acids)=226AA_start in transcript=447_stop in transcript=1127
MAEVSKVAEQVLNAVNKGLYREATELWGKAEMIIEQNTDGVNFYNILTKSTPTSTMESSLEFTQSHLVCLCQRHVRHLQRDALSQLMNGP
IRKKLKIIPEDQSWGGQATNVFVNMEEDFMKPVISIVDELLEAGINVTVYNGQLDLIVDTMGQEAWVRKLKWPELPKFSQLKWKALYSDP

--------------------------------------------------------------
>In-frame_ENST00000392334_ENST00000262288_TCGA-66-2783_CSNK1D_chr17_80231181_-_SCPEP1_chr17_55072867_length(transcript)=1622nt_BP=392nt
GCGCGATGGCGGCGGCTCCTTTAGGCAGCTGAAAGGGGATTTAGGCCCGGAAGATCCGAGTCCATCCGCGGCGGGGAGAGGGCAAGCGGG
ACCGGTAGGGGCCGGAGCAGCGGCGGCGGCGCTCGGACTGTCCCATCCGCCCCGTATTGAGGCGCTGGGAGCGGCGGGGCGACAGGAAAG
CGATGGTGAAAGCGGGGCCGTGAGGGGGGCGGAGCCGGGAGCCGGACCCGCAGTAGCGGCAGCAGCGGCGCCGCCTCCCAGAGTTCAGAC
CCAGGAAGCGGCCGGGAGGGCAGGAGCGAATCGGGCCGCCGCCGCCATGGAGCTGAGAGTCGGGAACAGGTACCGGCTGGGCCGGAAGAT
CGGCAGCGGCTCCTTCGGAGACATCTATCTCGTCTCTTCTCGAAGACAAAGGTCTGGCAGAGGTGTCTAAGGTTGCAGAGCAAGTACTGA
ATGCCGTAAATAAGGGGCTCTACAGAGAGGCCACAGAGCTGTGGGGGAAAGCAGAAATGATCATTGAACAGAACACAGATGGGGTGAACT
TCTATAACATCTTAACTAAAAGCACTCCCACGTCTACAATGGAGTCGAGTCTAGAATTCACACAGAGCCACCTAGTTTGTCTTTGTCAGC
GCCACGTGAGACACCTACAACGAGATGCCTTAAGCCAGCTCATGAATGGCCCCATCAGAAAGAAGCTCAAAATTATTCCTGAGGATCAAT
CCTGGGGAGGCCAGGCTACCAACGTCTTTGTGAACATGGAGGAGGACTTCATGAAGCCAGTCATTAGCATTGTGGACGAGTTGCTGGAGG
CAGGGATCAACGTGACGGTGTATAATGGACAGCTGGATCTCATCGTAGATACCATGGGTCAGGAGGCCTGGGTGCGGAAACTGAAGTGGC
CAGAACTGCCTAAATTCAGTCAGCTGAAGTGGAAGGCCCTGTACAGTGACCCTAAATCTTTGGAAACATCTGCTTTTGTCAAGTCCTACA
AGAACCTTGCTTTCTACTGGATTCTGAAAGCTGGTCATATGGTTCCTTCTGACCAAGGGGACATGGCTCTGAAGATGATGAGACTGGTGA
CTCAGCAAGAATAGGATGGATGGGGCTGGAGATGAGCTGGTTTGGCCTTGGGGCACAGAGCTGAGCTGAGGCCGCTGAAGCTGTAGGAAG
CGCCATTCTTCCCTGTATCTAACTGGGGCTGTGATCAAGAAGGTTCTGACCAGCTTCTGCAGAGGATAAAATCATTGTCTCTGGAGGCAA
TTTGGAAATTATTTCTGCTTCTTAAAAAAACCTAAGATTTTTTAAAAAATTGATTTGTTTTGATCAAAATAAAGGATGATAATAGATATT
ATTTTTTCTTATGACAGAAGCAAATGATGTGATTTATAGAAAAACTGGGAAATACAGGTACCCAAAGAGTAAATCAACATCTGTATACCC
CCTTCCCAGGGGTAAGCACTGTTACCAATTTAGCATATGTCCTTGCAGAATTTTTTTTTCTATATATACATATATATTTTTTACCAAAAT
GAATCATTACTCTATGTTGTTTTACTATTTGTTTGACATATCAGTATATCTGAAACACCTTTTCATGTCAATAAATGTTCTTCTCTAACA

>In-frame_ENST00000392334_ENST00000262288_TCGA-66-2783_CSNK1D_chr17_80231181_-_SCPEP1_chr17_55072867_length(amino acids)=226AA_start in transcript=413_stop in transcript=1093
MAEVSKVAEQVLNAVNKGLYREATELWGKAEMIIEQNTDGVNFYNILTKSTPTSTMESSLEFTQSHLVCLCQRHVRHLQRDALSQLMNGP
IRKKLKIIPEDQSWGGQATNVFVNMEEDFMKPVISIVDELLEAGINVTVYNGQLDLIVDTMGQEAWVRKLKWPELPKFSQLKWKALYSDP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CSNK1D-SCPEP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CSNK1D-SCPEP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CSNK1D-SCPEP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCSNK1DC3808874ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 23GENOMICS_ENGLAND;UNIPROT
HgeneCSNK1DC1858496Advanced Sleep-Phase Syndrome, Familial1CTD_human;ORPHANET