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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CTBP2-BIRC2 (FusionGDB2 ID:20046)

Fusion Gene Summary for CTBP2-BIRC2

check button Fusion gene summary
Fusion gene informationFusion gene name: CTBP2-BIRC2
Fusion gene ID: 20046
HgeneTgene
Gene symbol

CTBP2

BIRC2

Gene ID

1488

329

Gene nameC-terminal binding protein 2baculoviral IAP repeat containing 2
Synonyms-API1|HIAP2|Hiap-2|MIHB|RNF48|c-IAP1|cIAP1
Cytomap

10q26.13

11q22.2

Type of geneprotein-codingprotein-coding
DescriptionC-terminal-binding protein 2ribeyebaculoviral IAP repeat-containing protein 2IAP homolog BIAP-2NFR2-TRAF signalling complex proteinRING finger protein 48RING-type E3 ubiquitin transferase BIRC2TNFR2-TRAF-signaling complex protein 2apoptosis inhibitor 1cellular inhibitor of apoptos
Modification date2020031320200320
UniProtAcc.

Q13490

Ensembl transtripts involved in fusion geneENST00000337195, ENST00000531469, 
ENST00000494626, ENST00000411419, 
ENST00000476817, ENST00000309035, 
ENST00000334808, 		ENST00000530675, 
ENST00000227758, ENST00000532672, 
ENST00000527910, 
Fusion gene scores* DoF score20 X 14 X 8=22407 X 11 X 4=308
# samples 259
** MAII scorelog2(25/2240*10)=-3.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/308*10)=-1.77493344436523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTBP2 [Title/Abstract] AND BIRC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCTBP2(126776760)-BIRC2(102221575), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBIRC2

GO:0000209

protein polyubiquitination

11907583

TgeneBIRC2

GO:0043066

negative regulation of apoptotic process

21525013

TgeneBIRC2

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

11907583

TgeneBIRC2

GO:0051726

regulation of cell cycle

15665297

TgeneBIRC2

GO:1902523

positive regulation of protein K63-linked ubiquitination

21931591

TgeneBIRC2

GO:1902524

positive regulation of protein K48-linked ubiquitination

21931591

TgeneBIRC2

GO:1902527

positive regulation of protein monoubiquitination

21931591


check buttonFusion gene breakpoints across CTBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across BIRC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8527-01ACTBP2chr10

126776760

-BIRC2chr11

102221575

+


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Fusion Gene ORF analysis for CTBP2-BIRC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000337195ENST00000530675CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000337195ENST00000227758CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000337195ENST00000532672CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3UTRENST00000337195ENST00000527910CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000531469ENST00000530675CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000531469ENST00000227758CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000531469ENST00000532672CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3UTRENST00000531469ENST00000527910CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000494626ENST00000530675CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000494626ENST00000227758CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000494626ENST00000532672CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3UTRENST00000494626ENST00000527910CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000411419ENST00000530675CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000411419ENST00000227758CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000411419ENST00000532672CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3UTRENST00000411419ENST00000527910CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000476817ENST00000530675CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000476817ENST00000227758CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000476817ENST00000532672CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3UTRENST00000476817ENST00000527910CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000309035ENST00000530675CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000309035ENST00000227758CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000309035ENST00000532672CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3UTRENST00000309035ENST00000527910CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000334808ENST00000530675CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000334808ENST00000227758CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3CDSENST00000334808ENST00000532672CTBP2chr10

126776760

-BIRC2chr11

102221575

+
intron-3UTRENST00000334808ENST00000527910CTBP2chr10

126776760

-BIRC2chr11

102221575

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CTBP2-BIRC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CTBP2-BIRC2


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BIRC2

Q13490

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. {ECO:0000269|PubMed:15665297, ECO:0000269|PubMed:18082613, ECO:0000269|PubMed:21145488, ECO:0000269|PubMed:21653699, ECO:0000269|PubMed:21931591, ECO:0000269|PubMed:23453969}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CTBP2-BIRC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CTBP2-BIRC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CTBP2-BIRC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CTBP2-BIRC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTBP2C0007621Neoplastic Cell Transformation1CTD_human
HgeneCTBP2C0027626Neoplasm Invasiveness1CTD_human
HgeneCTBP2C0033578Prostatic Neoplasms1CTD_human
HgeneCTBP2C0376358Malignant neoplasm of prostate1CTD_human
TgeneBIRC2C0006142Malignant neoplasm of breast1CTD_human
TgeneBIRC2C0019693HIV Infections1CTD_human
TgeneBIRC2C0023418leukemia1CTD_human
TgeneBIRC2C0024623Malignant neoplasm of stomach1CTD_human
TgeneBIRC2C0038356Stomach Neoplasms1CTD_human
TgeneBIRC2C0678222Breast Carcinoma1CTD_human
TgeneBIRC2C1257931Mammary Neoplasms, Human1CTD_human
TgeneBIRC2C1458155Mammary Neoplasms1CTD_human
TgeneBIRC2C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneBIRC2C4505456HIV Coinfection1CTD_human
TgeneBIRC2C4704874Mammary Carcinoma, Human1CTD_human