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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CTTN-PPP6R3 (FusionGDB2 ID:20576) |
Fusion Gene Summary for CTTN-PPP6R3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CTTN-PPP6R3 | Fusion gene ID: 20576 | Hgene | Tgene | Gene symbol | CTTN | PPP6R3 | Gene ID | 2017 | 55291 |
| Gene name | cortactin | protein phosphatase 6 regulatory subunit 3 | |
| Synonyms | EMS1 | C11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3 | |
| Cytomap | 11q13.3 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | src substrate cortactin1110020L01Rikamplaxinems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)epididymis secretory sperm binding proteinoncogene EMS1 | serine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPL | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | Q14247 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000346329, ENST00000301843, ENST00000527622, ENST00000376561, ENST00000538675, | ENST00000393799, ENST00000530427, ENST00000393800, ENST00000534534, ENST00000524845, ENST00000265637, ENST00000524904, ENST00000393801, ENST00000265636, ENST00000529710, ENST00000527403, | |
| Fusion gene scores | * DoF score | 35 X 27 X 11=10395 | 28 X 32 X 13=11648 |
| # samples | 43 | 38 | |
| ** MAII score | log2(43/10395*10)=-4.59540928815627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(38/11648*10)=-4.93793903186775 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CTTN [Title/Abstract] AND PPP6R3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CTTN(70271507)-PPP6R3(68350511), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | CTTN-PPP6R3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CTTN-PPP6R3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PPP6R3 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 16716191 |
| Fusion gene breakpoints across CTTN (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across PPP6R3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-E9-A1NA-01A | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| ChimerDB4 | SKCM | TCGA-YG-AA3P-06A | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| ChimerDB4 | SKCM | TCGA-YG-AA3P-06A | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| ChimerDB4 | SKCM | TCGA-YG-AA3P-06A | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| ChimerDB4 | SKCM | TCGA-YG-AA3P-06A | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| ChimerDB4 | SKCM | TCGA-YG-AA3P-06A | CTTN | chr11 | 70271507 | - | PPP6R3 | chr11 | 68350511 | + |
Top |
Fusion Gene ORF analysis for CTTN-PPP6R3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000346329 | ENST00000393799 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000346329 | ENST00000530427 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000346329 | ENST00000393800 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000346329 | ENST00000534534 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000346329 | ENST00000524845 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000346329 | ENST00000265637 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000346329 | ENST00000524904 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000346329 | ENST00000393801 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000346329 | ENST00000265636 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000346329 | ENST00000529710 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000346329 | ENST00000527403 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| Frame-shift | ENST00000301843 | ENST00000393799 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000301843 | ENST00000530427 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000301843 | ENST00000393800 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000301843 | ENST00000534534 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000301843 | ENST00000524845 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000301843 | ENST00000265637 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000301843 | ENST00000524904 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000301843 | ENST00000393801 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000301843 | ENST00000265636 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000301843 | ENST00000529710 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000301843 | ENST00000527403 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-3CDS | ENST00000527622 | ENST00000393799 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000527622 | ENST00000530427 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000527622 | ENST00000393800 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000527622 | ENST00000534534 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000527622 | ENST00000524845 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000527622 | ENST00000265637 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000527622 | ENST00000524904 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000527622 | ENST00000393801 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000527622 | ENST00000265636 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000527622 | ENST00000529710 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000527622 | ENST00000527403 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| Frame-shift | ENST00000376561 | ENST00000393799 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000376561 | ENST00000530427 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000376561 | ENST00000393800 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000376561 | ENST00000534534 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000376561 | ENST00000524845 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000376561 | ENST00000265637 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000376561 | ENST00000524904 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000376561 | ENST00000393801 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000376561 | ENST00000265636 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000376561 | ENST00000529710 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| 5CDS-intron | ENST00000376561 | ENST00000527403 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-3CDS | ENST00000538675 | ENST00000393799 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000538675 | ENST00000530427 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000538675 | ENST00000393800 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000538675 | ENST00000534534 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000538675 | ENST00000524845 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000538675 | ENST00000265637 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000538675 | ENST00000524904 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000538675 | ENST00000393801 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000538675 | ENST00000265636 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000538675 | ENST00000529710 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| intron-intron | ENST00000538675 | ENST00000527403 | CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315535 | + |
| Frame-shift | ENST00000346329 | ENST00000393799 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000530427 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000393800 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000534534 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000524845 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000265637 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000524904 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000393801 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000265636 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000529710 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000527403 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| Frame-shift | ENST00000301843 | ENST00000393799 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000530427 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000393800 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000534534 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000524845 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000265637 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000524904 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000393801 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000265636 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000529710 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000527403 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-3CDS | ENST00000527622 | ENST00000393799 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000530427 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000393800 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000534534 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000524845 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000265637 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000524904 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000393801 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000265636 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000529710 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000527403 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| Frame-shift | ENST00000376561 | ENST00000393799 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000530427 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000393800 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000534534 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000524845 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000265637 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000524904 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000393801 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000265636 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000529710 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000527403 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| Frame-shift | ENST00000538675 | ENST00000393799 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000530427 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000393800 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000534534 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000524845 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000265637 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000524904 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000393801 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000265636 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000529710 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000527403 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350511 | + |
| In-frame | ENST00000346329 | ENST00000393799 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000530427 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000393800 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000534534 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000524845 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000265637 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000524904 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000393801 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000265636 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000529710 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000346329 | ENST00000527403 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| In-frame | ENST00000301843 | ENST00000393799 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000530427 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000393800 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000534534 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000524845 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000265637 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000524904 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000393801 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000265636 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000529710 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000301843 | ENST00000527403 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-3CDS | ENST00000527622 | ENST00000393799 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000530427 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000393800 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000534534 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000524845 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000265637 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000524904 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000393801 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000265636 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000529710 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| intron-intron | ENST00000527622 | ENST00000527403 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| In-frame | ENST00000376561 | ENST00000393799 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000530427 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000393800 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000534534 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000524845 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000265637 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000524904 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000393801 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000265636 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000529710 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000376561 | ENST00000527403 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| In-frame | ENST00000538675 | ENST00000393799 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000530427 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000393800 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000534534 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000524845 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000265637 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000524904 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000393801 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000265636 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000529710 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| 5CDS-intron | ENST00000538675 | ENST00000527403 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + |
| Frame-shift | ENST00000346329 | ENST00000393799 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000346329 | ENST00000530427 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000346329 | ENST00000393800 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000346329 | ENST00000534534 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000346329 | ENST00000524845 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000346329 | ENST00000265637 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000346329 | ENST00000524904 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000346329 | ENST00000393801 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000346329 | ENST00000265636 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000346329 | ENST00000529710 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000346329 | ENST00000527403 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| Frame-shift | ENST00000301843 | ENST00000393799 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000301843 | ENST00000530427 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000301843 | ENST00000393800 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000301843 | ENST00000534534 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000301843 | ENST00000524845 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000301843 | ENST00000265637 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000301843 | ENST00000524904 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000301843 | ENST00000393801 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000301843 | ENST00000265636 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000301843 | ENST00000529710 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000301843 | ENST00000527403 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| intron-3CDS | ENST00000527622 | ENST00000393799 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| intron-intron | ENST00000527622 | ENST00000530427 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| intron-intron | ENST00000527622 | ENST00000393800 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| intron-intron | ENST00000527622 | ENST00000534534 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| intron-intron | ENST00000527622 | ENST00000524845 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| intron-intron | ENST00000527622 | ENST00000265637 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| intron-intron | ENST00000527622 | ENST00000524904 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| intron-intron | ENST00000527622 | ENST00000393801 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| intron-intron | ENST00000527622 | ENST00000265636 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| intron-intron | ENST00000527622 | ENST00000529710 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| intron-intron | ENST00000527622 | ENST00000527403 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| Frame-shift | ENST00000376561 | ENST00000393799 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000376561 | ENST00000530427 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000376561 | ENST00000393800 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000376561 | ENST00000534534 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000376561 | ENST00000524845 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000376561 | ENST00000265637 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000376561 | ENST00000524904 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000376561 | ENST00000393801 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000376561 | ENST00000265636 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000376561 | ENST00000529710 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000376561 | ENST00000527403 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| Frame-shift | ENST00000538675 | ENST00000393799 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000538675 | ENST00000530427 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000538675 | ENST00000393800 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000538675 | ENST00000534534 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000538675 | ENST00000524845 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000538675 | ENST00000265637 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000538675 | ENST00000524904 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000538675 | ENST00000393801 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000538675 | ENST00000265636 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000538675 | ENST00000529710 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| 5CDS-intron | ENST00000538675 | ENST00000527403 | CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358128 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000346329 | CTTN | chr11 | 70269101 | + | ENST00000393799 | PPP6R3 | chr11 | 68350511 | + | 4461 | 1154 | 308 | 2248 | 646 |
| ENST00000301843 | CTTN | chr11 | 70269101 | + | ENST00000393799 | PPP6R3 | chr11 | 68350511 | + | 4470 | 1163 | 206 | 2257 | 683 |
| ENST00000376561 | CTTN | chr11 | 70269101 | + | ENST00000393799 | PPP6R3 | chr11 | 68350511 | + | 4324 | 1017 | 171 | 2111 | 646 |
| ENST00000538675 | CTTN | chr11 | 70269101 | + | ENST00000393799 | PPP6R3 | chr11 | 68350511 | + | 3464 | 157 | 148 | 1251 | 367 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000346329 | ENST00000393799 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + | 0.000471308 | 0.99952877 |
| ENST00000301843 | ENST00000393799 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + | 0.000513543 | 0.99948645 |
| ENST00000376561 | ENST00000393799 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + | 0.000444295 | 0.99955565 |
| ENST00000538675 | ENST00000393799 | CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350511 | + | 0.000742147 | 0.99925786 |
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Fusion Genomic Features for CTTN-PPP6R3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350510 | + | 0.01020209 | 0.98979795 |
| CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350510 | + | 0.000854624 | 0.9991454 |
| CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358127 | + | 0.000585859 | 0.9994142 |
| CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315534 | + | 5.16E-07 | 0.9999995 |
| CTTN | chr11 | 70269101 | + | PPP6R3 | chr11 | 68350510 | + | 0.01020209 | 0.98979795 |
| CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68350510 | + | 0.000854624 | 0.9991454 |
| CTTN | chr11 | 70271507 | + | PPP6R3 | chr11 | 68358127 | + | 0.000585859 | 0.9994142 |
| CTTN | chr11 | 70265962 | + | PPP6R3 | chr11 | 68315534 | + | 5.16E-07 | 0.9999995 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CTTN-PPP6R3 |
| Go to FGviewer for the breakpoints of chr11:70269101-chr11:68350511 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CTTN | . |
| FUNCTION: Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879, ECO:0000269|PubMed:23144454}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000301843 | + | 12 | 18 | 117_153 | 319.0 | 551.0 | Repeat | Note=Cortactin 2 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000301843 | + | 12 | 18 | 154_190 | 319.0 | 551.0 | Repeat | Note=Cortactin 3 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000301843 | + | 12 | 18 | 191_227 | 319.0 | 551.0 | Repeat | Note=Cortactin 4 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000301843 | + | 12 | 18 | 228_264 | 319.0 | 551.0 | Repeat | Note=Cortactin 5 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000301843 | + | 12 | 18 | 265_301 | 319.0 | 551.0 | Repeat | Note=Cortactin 6 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000301843 | + | 12 | 18 | 80_116 | 319.0 | 551.0 | Repeat | Note=Cortactin 1 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000346329 | + | 11 | 17 | 117_153 | 282.0 | 514.0 | Repeat | Note=Cortactin 2 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000346329 | + | 11 | 17 | 154_190 | 282.0 | 514.0 | Repeat | Note=Cortactin 3 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000346329 | + | 11 | 17 | 191_227 | 282.0 | 514.0 | Repeat | Note=Cortactin 4 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000346329 | + | 11 | 17 | 228_264 | 282.0 | 514.0 | Repeat | Note=Cortactin 5 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000346329 | + | 11 | 17 | 80_116 | 282.0 | 514.0 | Repeat | Note=Cortactin 1 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000376561 | + | 11 | 19 | 117_153 | 282.0 | 635.0 | Repeat | Note=Cortactin 2 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000376561 | + | 11 | 19 | 154_190 | 282.0 | 635.0 | Repeat | Note=Cortactin 3 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000376561 | + | 11 | 19 | 191_227 | 282.0 | 635.0 | Repeat | Note=Cortactin 4 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000376561 | + | 11 | 19 | 228_264 | 282.0 | 635.0 | Repeat | Note=Cortactin 5 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000376561 | + | 11 | 19 | 80_116 | 282.0 | 635.0 | Repeat | Note=Cortactin 1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000301843 | + | 12 | 18 | 348_401 | 319.0 | 551.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000346329 | + | 11 | 17 | 348_401 | 282.0 | 514.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000376561 | + | 11 | 19 | 348_401 | 282.0 | 635.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000301843 | + | 12 | 18 | 492_550 | 319.0 | 551.0 | Domain | SH3 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000346329 | + | 11 | 17 | 492_550 | 282.0 | 514.0 | Domain | SH3 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000376561 | + | 11 | 19 | 492_550 | 282.0 | 635.0 | Domain | SH3 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000301843 | + | 12 | 18 | 302_324 | 319.0 | 551.0 | Repeat | Note=Cortactin 7%3B truncated |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000346329 | + | 11 | 17 | 265_301 | 282.0 | 514.0 | Repeat | Note=Cortactin 6 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000346329 | + | 11 | 17 | 302_324 | 282.0 | 514.0 | Repeat | Note=Cortactin 7%3B truncated |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000376561 | + | 11 | 19 | 265_301 | 282.0 | 635.0 | Repeat | Note=Cortactin 6 |
| Hgene | CTTN | chr11:70269101 | chr11:68350511 | ENST00000376561 | + | 11 | 19 | 302_324 | 282.0 | 635.0 | Repeat | Note=Cortactin 7%3B truncated |
Top |
Fusion Gene Sequence for CTTN-PPP6R3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000346329_ENST00000393799_TCGA-YG-AA3P-06A_CTTN_chr11_70269101_+_PPP6R3_chr11_68350511_length(transcript)=4461nt_BP=1154nt GGCCGGGCTAGCGCTTAGCCAGCTGCGGGCGGACCCCCGGGACTCTTGCGGGCCAAGACGCGGGAGGAGGCGGGGCAGGGGGCGGGGTCG CGCGGGGACCCGGATGCGGCCCCGCCCCCGCCCTCGGAACCGGAAGTAGAGCCTGGTGCCTGGGAGCGGCTGGCGCGGCGGAATCCAGGG CCGACCCGGGCCGGACCGACCCCAGGCGGCGACGGAATCAGTCCCCAATGCCTGGAAATTCCTCATTGGATTACTGTGTTTTAAACAGAA TTTCGTGAACAGCCTTTTATCTCCAAGCGGAAAGAAAGATGTGGAAAGCTTCAGCAGGCCACGCTGTGTCCATCGCCCAGGATGACGCGG GGGCCGATGACTGGGAGACCGACCCTGATTTTGTGAATGATGTGAGTGAGAAGGAGCAAAGATGGGGTGCCAAGACGGTGCAGGGCTCCG GGCACCAGGAGCATATCAACATACACAAGCTGAGGGAGAATGTCTTTCAAGAGCATCAGACCCTTAAGGAGAAGGAACTTGAAACAGGAC CAAAAGCTTCCCATGGCTATGGAGGGAAATTTGGTGTGGAACAAGACCGAATGGATAAGTCAGCTGTCGGCCACGAATATCAGTCGAAAC TTTCCAAGCACTGCTCGCAGGTGGACTCGGTCCGTGGCTTCGGAGGCAAGTTTGGTGTCCAGATGGACAGAGTTGATCAGTCTGCTGTAG GCTTTGAATACCAGGGGAAGACTGAGAAGCATGCCTCCCAGAAAGACTACTCCAGTGGTTTTGGCGGCAAGTATGGCGTGCAGGCCGACC GAGTAGACAAGAGCGCGGTGGGCTTCGACTACCAGGGCAAGACGGAGAAGCACGAGTCACAGAGAGATTACTCCAAAGGTTTCGGCGGCA AATACGGTATCGACAAGGACAAAGTGGATAAGAGCGCCGTTGGCTTTGAGTATCAAGGCAAAACGGAGAAGCACGAGTCCCAGAAAGACT ATGTGAAAGGGTTTGGAGGAAAATTTGGTGTGCAGACAGACAGACAAGACAAATGTGCCCTTGGCTGGGATCACCAGGAGAAATTGCAGC TGCATGAATCCCAAAAAGACTACTCCAAAGGATTCGGCGGGAAGTATGGGGTGCAGAAGGATCGGATGGATAAGGTTACAACCTGCCATA TTCATTCATCCAGTGATGATGAAATTGACTTTAAAGAAACGGGTTTCTCACAGGATTCTTCTTTGCAGCAAGCCTTTTCTGATTATCAGA TGCAACAAATGACGTCCAATTTTATTGACCAGTTTGGCTTCAACGATGAGAAGTTTGCAGATCAAGATGACATTGGCAATGTTTCTTTTG ATCGAGTATCAGACATCAACTTTACTCTCAATACAAATGAAAGTGGAAATATTGCCTTGTTTGAAGCATGTTGTAAGGAAAGAATACAAC AGTTTGATGATGGTGGCTCTGATGAGGAAGATATATGGGAGGAAAAGCACATCGCATTCACACCAGAATCCCAAAGACGATCCAGCTCGG GGAGTACAGACAGTGAGGAAAGTACAGACTCTGAAGAAGAAGATGGAGCAAAGCAAGACTTGTTTGAACCCAGCAGTGCCAACACGGAGG ATAAAATGGAGGTGGACCTGAGTGAACCACCCAACTGGTCAGCTAACTTTGATGTCCCAATGGAAACAACCCACGGTGCTCCATTGGATT CTGTGGGATCTGATGTCTGGAGCACAGAGGAGCCGATGCCAACTAAAGAGACGGGCTGGGCTTCTTTTTCAGAGTTCACGTCTTCCCTGA GCACAAAAGATTCTTTAAGGAGTAATTCTCCAGTGGAAATGGAAACCAGCACTGAACCCATGGACCCTCTGACTCCCAGTGCGGCTGCCC TGGCAGTGCAGCCAGAAGCGGCAGGCAGTGTGGCCATGGAAGCCAGCTCTGACGGAGAGGAGGATGCAGAAAGTACAGACAAGGTAACTG AGACAGTGATGAATGGCGGCATGAAGGAAACGCTCAGCCTCACTGTAGATGCCAAGACAGAGACTGCGGTCTTCAAAAGGTTATTGGGAG GATGCAGTGAGGAAGGGAAACTGTCTACCTCTCAAGATGCTGCTTGTAAAGACGCAGAGGAGTGTCCCGAGACTGCAGAGGCGAAGTGCG CGGCGCCCAGGCCTCCCAGCAGCAGTCCCGAGCAGAGGACTGGCCAACCAAGCGCACCAGGTGACACTTCAGTGAATGGCCCTGTATGAC GGGTGACGTCTGCTGCTGCTGACTGAGGACTGCAGACCGCCACCACTCAGGGGCTCTGGAGGGGTCAGCTGGAGCCCACCAAGCTGTCAC TGCTGCACTCACTCTGCAAGGGATCAGGACCAGCAACCTTTATATTCTAGATTCTAAGACATTGTACAGAGAAATTCAGAAGTGTAAAAA TATTGCACATTGACAAATACCAAGAATTTTTGCGTATGTTTATATTGTATTGTTCTAAATAATGGGTAGCCTGTGAAATAAGATCTTGCC ACCCATGTAATAATAGTAGTAATACTATAGTTAAAATGGCTGTAAGAATAGTTTTATAAAAGTGAATACACAGATCTATTGTATTTGAAA CATAACTTTGACAATTATTAGTGTGACCAAAGTATTAGGCGGTTTTCATACATTTTTCACCTTGTACAAAATTATGAATTCATTTTTCCT CCAGGCCGACAAGGAGTTGTAGAATGAAAATGCCCTCTAAGTGTTATTTTGGTTGTTCTAACTTACAAAAGTGATTTTGAATAAGAAATA TTTGGTGTTCTTTTTATAACCAGTTTTTGATTGGTAATTGTTTTCTGTATTGTTTAAAACGGATCAAAAATGTAAGTCTATTGGTAGAGA TTAAGTAAAGTATTTATTGCTACATCATAGTTGATAAATTGATGTTATCGTAAAGCCATATGTTCTGTTCAAGTCTTGTTTGCTTGAAAT GATTATTCCTACAAGTGAAACACTAGACTATTTGGAGTGTATATGGCTTGTGTTTTGGGATTTTTTTTTTTTTTTTTTGGCTTTTGTTTT TGTTTGTTTTTTTGTTTCATTTGGTAGTTCATCTGCCTTTTAACCCATTCACCAAAATTTACCTTGTTAACAAGCATCACCAATGAACAT TTCAGAGCAATCTGCATATTTAACAGACCTAAAATAAATCCTATTAGGCAAGTCAGTTGAAAATGCTCGTGCTGCTAATGGAATTAGAGT GCGTTCATTTTACAGGCTAGTATTTTAAAAGTAGAAATCAAAATCTGGCACCGAAGCATGCTAATTGTTTACTGTACCTTGTGAGGTTTT CACTCATAAATTTAAACCAGTGTATTTTTTTAGAACTGGTTTGTGTATATATATAGTGATTATGGATACTAATTCAATGTAATTTATAAT TTTCTATGTCAATACAAAAATACATCACAGCCTTCTCAAACAGCTCAAGCAATATATTGTATATTGCCATATCGTCTGGTGAAAGGGTTA AATTACTTCACCTCTTGCACTTTTAGATGCAAATCAGTTTTTCATTTCTGTAATAGAAAATTATTCACGTATTTTTACATCATTTGTTTT TCCTGACCAGTATTTAAAACCAAAAGGATATTCTGAAAAATGGCCAACAATTTTTTTAGAAGTAGCATCCCAAGCAGCGTGCCTAAACAT TACATTGCATATGGAAATAAAAGAATCAAACGTCTAATGCCTTATTATTTCTGATTTCCTTTTTCATTTTAAGTGGTGTGGAGATTCCAG CACTCCCAGGACAGTGGAGTCAGCAGTAAGCCCTGGGACAGGTGGCAAGGGTGGGTCCCTTGACCTTTGCACGCCTCCTCAGGAACCCCC TTTCCCGGGTGAGCCCCTCTCTGAAGAGACTGTCCTTGGGCCTCCTCTGGAAGCAGCACCCCCAGAGGACAGGGCTCCTCCTGCTTGCCT CAGGGCTGCCTGACTTGAATGGCGTTGGACCTCGGGGATTACTGGTAGATAATATGCTCTGGTCTCGCCTGGTGGTGAGTTTTGCCAGCC ATGGCCAGGGTTTGGCTCCACTGGTGGCACACGTGGCCTCCGTGGTATGGACCTGGTGGCTTCTCCATCCCACTGTGGCCTCTGTGGTAT GGACCTGGTGGCTTCTCCATCCTACCCAAGGTAACAGTGTCTTGCTTCATCCCACTGACTGCTGGGAGAGAGCCTCTGGGACTTTTCTTT GGGGCATCATTTTGTTTTGTCTTTCGTAGCAGGGAAAGGATATGACAATGGGGAGGACAGTTCTTTTGGAGGTTGGAGGGGCCAAGCCAA GGACAGGAGCAAGTGTGCCCTCATTTTGTTTCTACTTTTAATTTCTGTGTGTTGGCCATACTGAATTATGAGACTAACAGATGTCTACAA >In-frame_ENST00000346329_ENST00000393799_TCGA-YG-AA3P-06A_CTTN_chr11_70269101_+_PPP6R3_chr11_68350511_length(amino acids)=646AA_start in transcript=308_stop in transcript=2248 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGV EQDRMDKSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYSKGFG GKYGVQKDRMDKVTTCHIHSSSDDEIDFKETGFSQDSSLQQAFSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTN ESGNIALFEACCKERIQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSEESTDSEEEDGAKQDLFEPSSANTEDKMEVDLSEPPNW SANFDVPMETTHGAPLDSVGSDVWSTEEPMPTKETGWASFSEFTSSLSTKDSLRSNSPVEMETSTEPMDPLTPSAAALAVQPEAAGSVAM EASSDGEEDAESTDKVTETVMNGGMKETLSLTVDAKTETAVFKRLLGGCSEEGKLSTSQDAACKDAEECPETAEAKCAAPRPPSSSPEQR -------------------------------------------------------------- >In-frame_ENST00000301843_ENST00000393799_TCGA-YG-AA3P-06A_CTTN_chr11_70269101_+_PPP6R3_chr11_68350511_length(transcript)=4470nt_BP=1163nt GATGCGGCCCCGCCCCCGCCCTCGGAACCGGAAGTAGAGCCTGGTGCCTGGGAGCGGCTGGCGCGGCGGAATCCAGGGCCGACCCGGGCC GGACCGACCCCAGGCGGCGACGGAATCAGTCCCCAATGCCTGGAAATTCCTCATTGGATTACTGTGTTTTAAACAGAATTTCGTGAACAG CCTTTTATCTCCAAGCGGAAAGAAAGATGTGGAAAGCTTCAGCAGGCCACGCTGTGTCCATCGCCCAGGATGACGCGGGGGCCGATGACT GGGAGACCGACCCTGATTTTGTGAATGATGTGAGTGAGAAGGAGCAAAGATGGGGTGCCAAGACGGTGCAGGGCTCCGGGCACCAGGAGC ATATCAACATACACAAGCTGAGGGAGAATGTCTTTCAAGAGCATCAGACCCTTAAGGAGAAGGAACTTGAAACAGGACCAAAAGCTTCCC ATGGCTATGGAGGGAAATTTGGTGTGGAACAAGACCGAATGGATAAGTCAGCTGTCGGCCACGAATATCAGTCGAAACTTTCCAAGCACT GCTCGCAGGTGGACTCGGTCCGTGGCTTCGGAGGCAAGTTTGGTGTCCAGATGGACAGAGTTGATCAGTCTGCTGTAGGCTTTGAATACC AGGGGAAGACTGAGAAGCATGCCTCCCAGAAAGACTACTCCAGTGGTTTTGGCGGCAAGTATGGCGTGCAGGCCGACCGAGTAGACAAGA GCGCGGTGGGCTTCGACTACCAGGGCAAGACGGAGAAGCACGAGTCACAGAGAGATTACTCCAAAGGTTTCGGCGGCAAATACGGTATCG ACAAGGACAAAGTGGATAAGAGCGCCGTTGGCTTTGAGTATCAAGGCAAAACGGAGAAGCACGAGTCCCAGAAAGACTATGTGAAAGGGT TTGGAGGAAAATTTGGTGTGCAGACAGACAGACAAGACAAATGTGCCCTTGGCTGGGATCACCAGGAGAAATTGCAGCTGCATGAATCCC AAAAAGATTATAAGACTGGTTTTGGAGGCAAATTCGGTGTTCAGTCGGAGAGGCAGGACTCCGCTGCTGTGGGGTTTGATTACAAGGAGA AGCTGGCCAAGCACGAGTCCCAGCAAGACTACTCCAAAGGATTCGGCGGGAAGTATGGGGTGCAGAAGGATCGGATGGATAAGGTTACAA CCTGCCATATTCATTCATCCAGTGATGATGAAATTGACTTTAAAGAAACGGGTTTCTCACAGGATTCTTCTTTGCAGCAAGCCTTTTCTG ATTATCAGATGCAACAAATGACGTCCAATTTTATTGACCAGTTTGGCTTCAACGATGAGAAGTTTGCAGATCAAGATGACATTGGCAATG TTTCTTTTGATCGAGTATCAGACATCAACTTTACTCTCAATACAAATGAAAGTGGAAATATTGCCTTGTTTGAAGCATGTTGTAAGGAAA GAATACAACAGTTTGATGATGGTGGCTCTGATGAGGAAGATATATGGGAGGAAAAGCACATCGCATTCACACCAGAATCCCAAAGACGAT CCAGCTCGGGGAGTACAGACAGTGAGGAAAGTACAGACTCTGAAGAAGAAGATGGAGCAAAGCAAGACTTGTTTGAACCCAGCAGTGCCA ACACGGAGGATAAAATGGAGGTGGACCTGAGTGAACCACCCAACTGGTCAGCTAACTTTGATGTCCCAATGGAAACAACCCACGGTGCTC CATTGGATTCTGTGGGATCTGATGTCTGGAGCACAGAGGAGCCGATGCCAACTAAAGAGACGGGCTGGGCTTCTTTTTCAGAGTTCACGT CTTCCCTGAGCACAAAAGATTCTTTAAGGAGTAATTCTCCAGTGGAAATGGAAACCAGCACTGAACCCATGGACCCTCTGACTCCCAGTG CGGCTGCCCTGGCAGTGCAGCCAGAAGCGGCAGGCAGTGTGGCCATGGAAGCCAGCTCTGACGGAGAGGAGGATGCAGAAAGTACAGACA AGGTAACTGAGACAGTGATGAATGGCGGCATGAAGGAAACGCTCAGCCTCACTGTAGATGCCAAGACAGAGACTGCGGTCTTCAAAAGGT TATTGGGAGGATGCAGTGAGGAAGGGAAACTGTCTACCTCTCAAGATGCTGCTTGTAAAGACGCAGAGGAGTGTCCCGAGACTGCAGAGG CGAAGTGCGCGGCGCCCAGGCCTCCCAGCAGCAGTCCCGAGCAGAGGACTGGCCAACCAAGCGCACCAGGTGACACTTCAGTGAATGGCC CTGTATGACGGGTGACGTCTGCTGCTGCTGACTGAGGACTGCAGACCGCCACCACTCAGGGGCTCTGGAGGGGTCAGCTGGAGCCCACCA AGCTGTCACTGCTGCACTCACTCTGCAAGGGATCAGGACCAGCAACCTTTATATTCTAGATTCTAAGACATTGTACAGAGAAATTCAGAA GTGTAAAAATATTGCACATTGACAAATACCAAGAATTTTTGCGTATGTTTATATTGTATTGTTCTAAATAATGGGTAGCCTGTGAAATAA GATCTTGCCACCCATGTAATAATAGTAGTAATACTATAGTTAAAATGGCTGTAAGAATAGTTTTATAAAAGTGAATACACAGATCTATTG TATTTGAAACATAACTTTGACAATTATTAGTGTGACCAAAGTATTAGGCGGTTTTCATACATTTTTCACCTTGTACAAAATTATGAATTC ATTTTTCCTCCAGGCCGACAAGGAGTTGTAGAATGAAAATGCCCTCTAAGTGTTATTTTGGTTGTTCTAACTTACAAAAGTGATTTTGAA TAAGAAATATTTGGTGTTCTTTTTATAACCAGTTTTTGATTGGTAATTGTTTTCTGTATTGTTTAAAACGGATCAAAAATGTAAGTCTAT TGGTAGAGATTAAGTAAAGTATTTATTGCTACATCATAGTTGATAAATTGATGTTATCGTAAAGCCATATGTTCTGTTCAAGTCTTGTTT GCTTGAAATGATTATTCCTACAAGTGAAACACTAGACTATTTGGAGTGTATATGGCTTGTGTTTTGGGATTTTTTTTTTTTTTTTTTGGC TTTTGTTTTTGTTTGTTTTTTTGTTTCATTTGGTAGTTCATCTGCCTTTTAACCCATTCACCAAAATTTACCTTGTTAACAAGCATCACC AATGAACATTTCAGAGCAATCTGCATATTTAACAGACCTAAAATAAATCCTATTAGGCAAGTCAGTTGAAAATGCTCGTGCTGCTAATGG AATTAGAGTGCGTTCATTTTACAGGCTAGTATTTTAAAAGTAGAAATCAAAATCTGGCACCGAAGCATGCTAATTGTTTACTGTACCTTG TGAGGTTTTCACTCATAAATTTAAACCAGTGTATTTTTTTAGAACTGGTTTGTGTATATATATAGTGATTATGGATACTAATTCAATGTA ATTTATAATTTTCTATGTCAATACAAAAATACATCACAGCCTTCTCAAACAGCTCAAGCAATATATTGTATATTGCCATATCGTCTGGTG AAAGGGTTAAATTACTTCACCTCTTGCACTTTTAGATGCAAATCAGTTTTTCATTTCTGTAATAGAAAATTATTCACGTATTTTTACATC ATTTGTTTTTCCTGACCAGTATTTAAAACCAAAAGGATATTCTGAAAAATGGCCAACAATTTTTTTAGAAGTAGCATCCCAAGCAGCGTG CCTAAACATTACATTGCATATGGAAATAAAAGAATCAAACGTCTAATGCCTTATTATTTCTGATTTCCTTTTTCATTTTAAGTGGTGTGG AGATTCCAGCACTCCCAGGACAGTGGAGTCAGCAGTAAGCCCTGGGACAGGTGGCAAGGGTGGGTCCCTTGACCTTTGCACGCCTCCTCA GGAACCCCCTTTCCCGGGTGAGCCCCTCTCTGAAGAGACTGTCCTTGGGCCTCCTCTGGAAGCAGCACCCCCAGAGGACAGGGCTCCTCC TGCTTGCCTCAGGGCTGCCTGACTTGAATGGCGTTGGACCTCGGGGATTACTGGTAGATAATATGCTCTGGTCTCGCCTGGTGGTGAGTT TTGCCAGCCATGGCCAGGGTTTGGCTCCACTGGTGGCACACGTGGCCTCCGTGGTATGGACCTGGTGGCTTCTCCATCCCACTGTGGCCT CTGTGGTATGGACCTGGTGGCTTCTCCATCCTACCCAAGGTAACAGTGTCTTGCTTCATCCCACTGACTGCTGGGAGAGAGCCTCTGGGA CTTTTCTTTGGGGCATCATTTTGTTTTGTCTTTCGTAGCAGGGAAAGGATATGACAATGGGGAGGACAGTTCTTTTGGAGGTTGGAGGGG CCAAGCCAAGGACAGGAGCAAGTGTGCCCTCATTTTGTTTCTACTTTTAATTTCTGTGTGTTGGCCATACTGAATTATGAGACTAACAGA >In-frame_ENST00000301843_ENST00000393799_TCGA-YG-AA3P-06A_CTTN_chr11_70269101_+_PPP6R3_chr11_68350511_length(amino acids)=683AA_start in transcript=206_stop in transcript=2257 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGV EQDRMDKSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKTGFG GKFGVQSERQDSAAVGFDYKEKLAKHESQQDYSKGFGGKYGVQKDRMDKVTTCHIHSSSDDEIDFKETGFSQDSSLQQAFSDYQMQQMTS NFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTNESGNIALFEACCKERIQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSE ESTDSEEEDGAKQDLFEPSSANTEDKMEVDLSEPPNWSANFDVPMETTHGAPLDSVGSDVWSTEEPMPTKETGWASFSEFTSSLSTKDSL RSNSPVEMETSTEPMDPLTPSAAALAVQPEAAGSVAMEASSDGEEDAESTDKVTETVMNGGMKETLSLTVDAKTETAVFKRLLGGCSEEG -------------------------------------------------------------- >In-frame_ENST00000376561_ENST00000393799_TCGA-YG-AA3P-06A_CTTN_chr11_70269101_+_PPP6R3_chr11_68350511_length(transcript)=4324nt_BP=1017nt AGAGCCTGGTGCCTGGGAGCGGCTGGCGCGGCGGAATCCAGGGCCGACCCGGGCCGGACCGACCCCAGGCGGCGACGGAATCAGTCCCCA ATGCCTGGAAATTCCTCATTGGATTACTGTGTTTTAAACAGAATTTCGTGAACAGCCTTTTATCTCCAAGCGGAAAGAAAGATGTGGAAA GCTTCAGCAGGCCACGCTGTGTCCATCGCCCAGGATGACGCGGGGGCCGATGACTGGGAGACCGACCCTGATTTTGTGAATGATGTGAGT GAGAAGGAGCAAAGATGGGGTGCCAAGACGGTGCAGGGCTCCGGGCACCAGGAGCATATCAACATACACAAGCTGAGGGAGAATGTCTTT CAAGAGCATCAGACCCTTAAGGAGAAGGAACTTGAAACAGGACCAAAAGCTTCCCATGGCTATGGAGGGAAATTTGGTGTGGAACAAGAC CGAATGGATAAGTCAGCTGTCGGCCACGAATATCAGTCGAAACTTTCCAAGCACTGCTCGCAGGTGGACTCGGTCCGTGGCTTCGGAGGC AAGTTTGGTGTCCAGATGGACAGAGTTGATCAGTCTGCTGTAGGCTTTGAATACCAGGGGAAGACTGAGAAGCATGCCTCCCAGAAAGAC TACTCCAGTGGTTTTGGCGGCAAGTATGGCGTGCAGGCCGACCGAGTAGACAAGAGCGCGGTGGGCTTCGACTACCAGGGCAAGACGGAG AAGCACGAGTCACAGAGAGATTACTCCAAAGGTTTCGGCGGCAAATACGGTATCGACAAGGACAAAGTGGATAAGAGCGCCGTTGGCTTT GAGTATCAAGGCAAAACGGAGAAGCACGAGTCCCAGAAAGACTATGTGAAAGGGTTTGGAGGAAAATTTGGTGTGCAGACAGACAGACAA GACAAATGTGCCCTTGGCTGGGATCACCAGGAGAAATTGCAGCTGCATGAATCCCAAAAAGACTACTCCAAAGGATTCGGCGGGAAGTAT GGGGTGCAGAAGGATCGGATGGATAAGGTTACAACCTGCCATATTCATTCATCCAGTGATGATGAAATTGACTTTAAAGAAACGGGTTTC TCACAGGATTCTTCTTTGCAGCAAGCCTTTTCTGATTATCAGATGCAACAAATGACGTCCAATTTTATTGACCAGTTTGGCTTCAACGAT GAGAAGTTTGCAGATCAAGATGACATTGGCAATGTTTCTTTTGATCGAGTATCAGACATCAACTTTACTCTCAATACAAATGAAAGTGGA AATATTGCCTTGTTTGAAGCATGTTGTAAGGAAAGAATACAACAGTTTGATGATGGTGGCTCTGATGAGGAAGATATATGGGAGGAAAAG CACATCGCATTCACACCAGAATCCCAAAGACGATCCAGCTCGGGGAGTACAGACAGTGAGGAAAGTACAGACTCTGAAGAAGAAGATGGA GCAAAGCAAGACTTGTTTGAACCCAGCAGTGCCAACACGGAGGATAAAATGGAGGTGGACCTGAGTGAACCACCCAACTGGTCAGCTAAC TTTGATGTCCCAATGGAAACAACCCACGGTGCTCCATTGGATTCTGTGGGATCTGATGTCTGGAGCACAGAGGAGCCGATGCCAACTAAA GAGACGGGCTGGGCTTCTTTTTCAGAGTTCACGTCTTCCCTGAGCACAAAAGATTCTTTAAGGAGTAATTCTCCAGTGGAAATGGAAACC AGCACTGAACCCATGGACCCTCTGACTCCCAGTGCGGCTGCCCTGGCAGTGCAGCCAGAAGCGGCAGGCAGTGTGGCCATGGAAGCCAGC TCTGACGGAGAGGAGGATGCAGAAAGTACAGACAAGGTAACTGAGACAGTGATGAATGGCGGCATGAAGGAAACGCTCAGCCTCACTGTA GATGCCAAGACAGAGACTGCGGTCTTCAAAAGGTTATTGGGAGGATGCAGTGAGGAAGGGAAACTGTCTACCTCTCAAGATGCTGCTTGT AAAGACGCAGAGGAGTGTCCCGAGACTGCAGAGGCGAAGTGCGCGGCGCCCAGGCCTCCCAGCAGCAGTCCCGAGCAGAGGACTGGCCAA CCAAGCGCACCAGGTGACACTTCAGTGAATGGCCCTGTATGACGGGTGACGTCTGCTGCTGCTGACTGAGGACTGCAGACCGCCACCACT CAGGGGCTCTGGAGGGGTCAGCTGGAGCCCACCAAGCTGTCACTGCTGCACTCACTCTGCAAGGGATCAGGACCAGCAACCTTTATATTC TAGATTCTAAGACATTGTACAGAGAAATTCAGAAGTGTAAAAATATTGCACATTGACAAATACCAAGAATTTTTGCGTATGTTTATATTG TATTGTTCTAAATAATGGGTAGCCTGTGAAATAAGATCTTGCCACCCATGTAATAATAGTAGTAATACTATAGTTAAAATGGCTGTAAGA ATAGTTTTATAAAAGTGAATACACAGATCTATTGTATTTGAAACATAACTTTGACAATTATTAGTGTGACCAAAGTATTAGGCGGTTTTC ATACATTTTTCACCTTGTACAAAATTATGAATTCATTTTTCCTCCAGGCCGACAAGGAGTTGTAGAATGAAAATGCCCTCTAAGTGTTAT TTTGGTTGTTCTAACTTACAAAAGTGATTTTGAATAAGAAATATTTGGTGTTCTTTTTATAACCAGTTTTTGATTGGTAATTGTTTTCTG TATTGTTTAAAACGGATCAAAAATGTAAGTCTATTGGTAGAGATTAAGTAAAGTATTTATTGCTACATCATAGTTGATAAATTGATGTTA TCGTAAAGCCATATGTTCTGTTCAAGTCTTGTTTGCTTGAAATGATTATTCCTACAAGTGAAACACTAGACTATTTGGAGTGTATATGGC TTGTGTTTTGGGATTTTTTTTTTTTTTTTTTGGCTTTTGTTTTTGTTTGTTTTTTTGTTTCATTTGGTAGTTCATCTGCCTTTTAACCCA TTCACCAAAATTTACCTTGTTAACAAGCATCACCAATGAACATTTCAGAGCAATCTGCATATTTAACAGACCTAAAATAAATCCTATTAG GCAAGTCAGTTGAAAATGCTCGTGCTGCTAATGGAATTAGAGTGCGTTCATTTTACAGGCTAGTATTTTAAAAGTAGAAATCAAAATCTG GCACCGAAGCATGCTAATTGTTTACTGTACCTTGTGAGGTTTTCACTCATAAATTTAAACCAGTGTATTTTTTTAGAACTGGTTTGTGTA TATATATAGTGATTATGGATACTAATTCAATGTAATTTATAATTTTCTATGTCAATACAAAAATACATCACAGCCTTCTCAAACAGCTCA AGCAATATATTGTATATTGCCATATCGTCTGGTGAAAGGGTTAAATTACTTCACCTCTTGCACTTTTAGATGCAAATCAGTTTTTCATTT CTGTAATAGAAAATTATTCACGTATTTTTACATCATTTGTTTTTCCTGACCAGTATTTAAAACCAAAAGGATATTCTGAAAAATGGCCAA CAATTTTTTTAGAAGTAGCATCCCAAGCAGCGTGCCTAAACATTACATTGCATATGGAAATAAAAGAATCAAACGTCTAATGCCTTATTA TTTCTGATTTCCTTTTTCATTTTAAGTGGTGTGGAGATTCCAGCACTCCCAGGACAGTGGAGTCAGCAGTAAGCCCTGGGACAGGTGGCA AGGGTGGGTCCCTTGACCTTTGCACGCCTCCTCAGGAACCCCCTTTCCCGGGTGAGCCCCTCTCTGAAGAGACTGTCCTTGGGCCTCCTC TGGAAGCAGCACCCCCAGAGGACAGGGCTCCTCCTGCTTGCCTCAGGGCTGCCTGACTTGAATGGCGTTGGACCTCGGGGATTACTGGTA GATAATATGCTCTGGTCTCGCCTGGTGGTGAGTTTTGCCAGCCATGGCCAGGGTTTGGCTCCACTGGTGGCACACGTGGCCTCCGTGGTA TGGACCTGGTGGCTTCTCCATCCCACTGTGGCCTCTGTGGTATGGACCTGGTGGCTTCTCCATCCTACCCAAGGTAACAGTGTCTTGCTT CATCCCACTGACTGCTGGGAGAGAGCCTCTGGGACTTTTCTTTGGGGCATCATTTTGTTTTGTCTTTCGTAGCAGGGAAAGGATATGACA ATGGGGAGGACAGTTCTTTTGGAGGTTGGAGGGGCCAAGCCAAGGACAGGAGCAAGTGTGCCCTCATTTTGTTTCTACTTTTAATTTCTG TGTGTTGGCCATACTGAATTATGAGACTAACAGATGTCTACAATACAATACCTGTATTCAAAATAACAAAAATAAAGCCTGATTCTTTGT >In-frame_ENST00000376561_ENST00000393799_TCGA-YG-AA3P-06A_CTTN_chr11_70269101_+_PPP6R3_chr11_68350511_length(amino acids)=646AA_start in transcript=171_stop in transcript=2111 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGV EQDRMDKSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYSKGFG GKYGVQKDRMDKVTTCHIHSSSDDEIDFKETGFSQDSSLQQAFSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTN ESGNIALFEACCKERIQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSEESTDSEEEDGAKQDLFEPSSANTEDKMEVDLSEPPNW SANFDVPMETTHGAPLDSVGSDVWSTEEPMPTKETGWASFSEFTSSLSTKDSLRSNSPVEMETSTEPMDPLTPSAAALAVQPEAAGSVAM EASSDGEEDAESTDKVTETVMNGGMKETLSLTVDAKTETAVFKRLLGGCSEEGKLSTSQDAACKDAEECPETAEAKCAAPRPPSSSPEQR -------------------------------------------------------------- >In-frame_ENST00000538675_ENST00000393799_TCGA-YG-AA3P-06A_CTTN_chr11_70269101_+_PPP6R3_chr11_68350511_length(transcript)=3464nt_BP=157nt GCATGAATCCCAAAAAGCAAGAGAACAAACTGCGATTGAGCCTCTTTTTAGCGCTCAGTAGAGCAGGCGCACAGGAAGCAGATGAGAATA AGCCCGTGCTGACTACTCCAAAGGATTCGGCGGGAAGTATGGGGTGCAGAAGGATCGGATGGATAAGGTTACAACCTGCCATATTCATTC ATCCAGTGATGATGAAATTGACTTTAAAGAAACGGGTTTCTCACAGGATTCTTCTTTGCAGCAAGCCTTTTCTGATTATCAGATGCAACA AATGACGTCCAATTTTATTGACCAGTTTGGCTTCAACGATGAGAAGTTTGCAGATCAAGATGACATTGGCAATGTTTCTTTTGATCGAGT ATCAGACATCAACTTTACTCTCAATACAAATGAAAGTGGAAATATTGCCTTGTTTGAAGCATGTTGTAAGGAAAGAATACAACAGTTTGA TGATGGTGGCTCTGATGAGGAAGATATATGGGAGGAAAAGCACATCGCATTCACACCAGAATCCCAAAGACGATCCAGCTCGGGGAGTAC AGACAGTGAGGAAAGTACAGACTCTGAAGAAGAAGATGGAGCAAAGCAAGACTTGTTTGAACCCAGCAGTGCCAACACGGAGGATAAAAT GGAGGTGGACCTGAGTGAACCACCCAACTGGTCAGCTAACTTTGATGTCCCAATGGAAACAACCCACGGTGCTCCATTGGATTCTGTGGG ATCTGATGTCTGGAGCACAGAGGAGCCGATGCCAACTAAAGAGACGGGCTGGGCTTCTTTTTCAGAGTTCACGTCTTCCCTGAGCACAAA AGATTCTTTAAGGAGTAATTCTCCAGTGGAAATGGAAACCAGCACTGAACCCATGGACCCTCTGACTCCCAGTGCGGCTGCCCTGGCAGT GCAGCCAGAAGCGGCAGGCAGTGTGGCCATGGAAGCCAGCTCTGACGGAGAGGAGGATGCAGAAAGTACAGACAAGGTAACTGAGACAGT GATGAATGGCGGCATGAAGGAAACGCTCAGCCTCACTGTAGATGCCAAGACAGAGACTGCGGTCTTCAAAAGGTTATTGGGAGGATGCAG TGAGGAAGGGAAACTGTCTACCTCTCAAGATGCTGCTTGTAAAGACGCAGAGGAGTGTCCCGAGACTGCAGAGGCGAAGTGCGCGGCGCC CAGGCCTCCCAGCAGCAGTCCCGAGCAGAGGACTGGCCAACCAAGCGCACCAGGTGACACTTCAGTGAATGGCCCTGTATGACGGGTGAC GTCTGCTGCTGCTGACTGAGGACTGCAGACCGCCACCACTCAGGGGCTCTGGAGGGGTCAGCTGGAGCCCACCAAGCTGTCACTGCTGCA CTCACTCTGCAAGGGATCAGGACCAGCAACCTTTATATTCTAGATTCTAAGACATTGTACAGAGAAATTCAGAAGTGTAAAAATATTGCA CATTGACAAATACCAAGAATTTTTGCGTATGTTTATATTGTATTGTTCTAAATAATGGGTAGCCTGTGAAATAAGATCTTGCCACCCATG TAATAATAGTAGTAATACTATAGTTAAAATGGCTGTAAGAATAGTTTTATAAAAGTGAATACACAGATCTATTGTATTTGAAACATAACT TTGACAATTATTAGTGTGACCAAAGTATTAGGCGGTTTTCATACATTTTTCACCTTGTACAAAATTATGAATTCATTTTTCCTCCAGGCC GACAAGGAGTTGTAGAATGAAAATGCCCTCTAAGTGTTATTTTGGTTGTTCTAACTTACAAAAGTGATTTTGAATAAGAAATATTTGGTG TTCTTTTTATAACCAGTTTTTGATTGGTAATTGTTTTCTGTATTGTTTAAAACGGATCAAAAATGTAAGTCTATTGGTAGAGATTAAGTA AAGTATTTATTGCTACATCATAGTTGATAAATTGATGTTATCGTAAAGCCATATGTTCTGTTCAAGTCTTGTTTGCTTGAAATGATTATT CCTACAAGTGAAACACTAGACTATTTGGAGTGTATATGGCTTGTGTTTTGGGATTTTTTTTTTTTTTTTTTGGCTTTTGTTTTTGTTTGT TTTTTTGTTTCATTTGGTAGTTCATCTGCCTTTTAACCCATTCACCAAAATTTACCTTGTTAACAAGCATCACCAATGAACATTTCAGAG CAATCTGCATATTTAACAGACCTAAAATAAATCCTATTAGGCAAGTCAGTTGAAAATGCTCGTGCTGCTAATGGAATTAGAGTGCGTTCA TTTTACAGGCTAGTATTTTAAAAGTAGAAATCAAAATCTGGCACCGAAGCATGCTAATTGTTTACTGTACCTTGTGAGGTTTTCACTCAT AAATTTAAACCAGTGTATTTTTTTAGAACTGGTTTGTGTATATATATAGTGATTATGGATACTAATTCAATGTAATTTATAATTTTCTAT GTCAATACAAAAATACATCACAGCCTTCTCAAACAGCTCAAGCAATATATTGTATATTGCCATATCGTCTGGTGAAAGGGTTAAATTACT TCACCTCTTGCACTTTTAGATGCAAATCAGTTTTTCATTTCTGTAATAGAAAATTATTCACGTATTTTTACATCATTTGTTTTTCCTGAC CAGTATTTAAAACCAAAAGGATATTCTGAAAAATGGCCAACAATTTTTTTAGAAGTAGCATCCCAAGCAGCGTGCCTAAACATTACATTG CATATGGAAATAAAAGAATCAAACGTCTAATGCCTTATTATTTCTGATTTCCTTTTTCATTTTAAGTGGTGTGGAGATTCCAGCACTCCC AGGACAGTGGAGTCAGCAGTAAGCCCTGGGACAGGTGGCAAGGGTGGGTCCCTTGACCTTTGCACGCCTCCTCAGGAACCCCCTTTCCCG GGTGAGCCCCTCTCTGAAGAGACTGTCCTTGGGCCTCCTCTGGAAGCAGCACCCCCAGAGGACAGGGCTCCTCCTGCTTGCCTCAGGGCT GCCTGACTTGAATGGCGTTGGACCTCGGGGATTACTGGTAGATAATATGCTCTGGTCTCGCCTGGTGGTGAGTTTTGCCAGCCATGGCCA GGGTTTGGCTCCACTGGTGGCACACGTGGCCTCCGTGGTATGGACCTGGTGGCTTCTCCATCCCACTGTGGCCTCTGTGGTATGGACCTG GTGGCTTCTCCATCCTACCCAAGGTAACAGTGTCTTGCTTCATCCCACTGACTGCTGGGAGAGAGCCTCTGGGACTTTTCTTTGGGGCAT CATTTTGTTTTGTCTTTCGTAGCAGGGAAAGGATATGACAATGGGGAGGACAGTTCTTTTGGAGGTTGGAGGGGCCAAGCCAAGGACAGG AGCAAGTGTGCCCTCATTTTGTTTCTACTTTTAATTTCTGTGTGTTGGCCATACTGAATTATGAGACTAACAGATGTCTACAATACAATA >In-frame_ENST00000538675_ENST00000393799_TCGA-YG-AA3P-06A_CTTN_chr11_70269101_+_PPP6R3_chr11_68350511_length(amino acids)=367AA_start in transcript=148_stop in transcript=1251 MDKVTTCHIHSSSDDEIDFKETGFSQDSSLQQAFSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTNESGNIALFE ACCKERIQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSEESTDSEEEDGAKQDLFEPSSANTEDKMEVDLSEPPNWSANFDVPME TTHGAPLDSVGSDVWSTEEPMPTKETGWASFSEFTSSLSTKDSLRSNSPVEMETSTEPMDPLTPSAAALAVQPEAAGSVAMEASSDGEED AESTDKVTETVMNGGMKETLSLTVDAKTETAVFKRLLGGCSEEGKLSTSQDAACKDAEECPETAEAKCAAPRPPSSSPEQRTGQPSAPGD -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CTTN-PPP6R3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CTTN-PPP6R3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CTTN-PPP6R3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CTTN | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | CTTN | C0023531 | Leukoplakia | 1 | CTD_human |
| Hgene | CTTN | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human |
| Hgene | CTTN | C1704317 | Leukokeratosis | 1 | CTD_human |
| Hgene | CTTN | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Hgene | CTTN | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human |
| Hgene | CTTN | C4552091 | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 1 | CTD_human |
| Hgene | CTTN | C4704862 | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 1 | CTD_human |
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